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<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAW1</accession>
    <name>A0A084VAW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000996</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC000996-RA">
        <property type="protein sequence ID" value="ASIC000996-PA"/>
        <property type="gene ID" value="ASIC000996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000996"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="66"/>
            <end position="107"/>
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    </feature>
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        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="12559" checksum="E2A3F908D54F0DD8" modified="2014-10-29" version="1">MEPLVRRTYRQQARQLVANIANLRRRQRTLSPATYAARMELREAHLRRHDAPPDGIEAADARVAEAERNRDNVAREHRNAMQREWRRDTANLKGHSPCKGKKKIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB31</accession>
    <name>A0A084VB31_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001149</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001149-RA">
        <property type="protein sequence ID" value="ASIC001149-PA"/>
        <property type="gene ID" value="ASIC001149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001149"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="18090" checksum="1FFDB4B716C5DEBF" modified="2014-10-29" version="1">MDRVWPHGRSWSSSWIVLSLAREKYLIEMNNSVRTIREASAIGEDFKYLPTFVHRAWLDTNDIFSAPTRLVRPKPHPKTLDKSEPFVWQRRHKPSRGKWNCFGCLGNLSGSLRNGHECDCDAVVKLHRSPGALIAAVVNRAALGLELEYASPEANLLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBC9</accession>
    <name>A0A084VBC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007823-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001447</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524352">
        <property type="protein sequence ID" value="KFB35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBC9"/>
    <dbReference type="STRING" id="74873.A0A084VBC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001447-RA">
        <property type="protein sequence ID" value="ASIC001447-PA"/>
        <property type="gene ID" value="ASIC001447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001447"/>
    <dbReference type="OrthoDB" id="8197574at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="440" mass="48153" checksum="929653C81CE9D5CB" modified="2014-10-29" version="1">MNNSISSSFYDMRSFPEFVTNLAAESAKMYNTRQSYTGQGGYNMKFYNYYQQTAPYVSQMYGNCYPKQRYMPYPNRNNGGGVGVGPSNGSATISNHQSTHCSLQQQQQPPQHLQPSSANTSSYCQQATNKSLNSSLNSSNYSDSGRNSTFYSSNNSGCSSPHHSSYSNDSAGTASTGALGGSANISGTAGSGSGSSASVSPKMPAPASQSQGPTQSQPGTAAPSESEQKEMVVLQISNLDASIDEHKMHQFLLCQLKPITPVISLTIESPSLAKVKVPSAQVSFSQTPRCGRGWFDGIFLSPSPHLVRKTVVANLHRKKVGHKRMVVSYIKDPSSAESSALRCQVAGLLKDVPFYSLPINRFRELFQSRFKSSISVLDLYRMQDVCTITLDKNDEKYIALQPDLIDTLKNSSLVETSQHSVPYCMYHFQQEKERVGRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBR3</accession>
    <name>A0A084VBR3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nucleolar protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002046</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524503">
        <property type="protein sequence ID" value="KFB35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002046-RA">
        <property type="protein sequence ID" value="ASIC002046-PA"/>
        <property type="gene ID" value="ASIC002046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002046"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="9126" checksum="E5AE5B07A8105F68" modified="2014-10-29" version="1">MERTKWKPGRAAGGQGRDPFLSRLQNFHRGAARKLQRLGGGKFCGFVSGRSVPGHRQFQGSSFGEGPQCRTIKVYLEIIHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBY9</accession>
    <name>A0A084VBY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002253</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524552">
        <property type="protein sequence ID" value="KFB35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002253-RA">
        <property type="protein sequence ID" value="ASIC002253-PA"/>
        <property type="gene ID" value="ASIC002253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002253"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9425" checksum="A5E2A5D221DE5FA3" modified="2014-10-29" version="1">MGTVVAYKIDTDEGHHSVCRKSTTSAIEHTTNNPSLRRSEENVTHGMGQQQRPFGNRHKVQRFACAVRPTFNVAGPGSGDEFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCX9</accession>
    <name>A0A084VCX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP002548-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002751</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524630">
        <property type="protein sequence ID" value="KFB35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCX9"/>
    <dbReference type="STRING" id="74873.A0A084VCX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002751-RA">
        <property type="protein sequence ID" value="ASIC002751-PA"/>
        <property type="gene ID" value="ASIC002751"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002751"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002751-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="10225" checksum="1977FEBA036DE169" modified="2014-10-29" version="1">MSLVICSSSHKADFYNSNDVQLYATPDGCRSNEYFDLFAMKCLVCDDGLHLIPGKDSEYRRDLHSQFKLFDRWPYRLNSLNCCSCVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD28</accession>
    <name>A0A084VD28_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynamin-like GTPase OPA1, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00002823</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01011135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524643">
        <property type="protein sequence ID" value="KFB35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD28"/>
    <dbReference type="STRING" id="74873.A0A084VD28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002823-RA">
        <property type="protein sequence ID" value="ASIC002823-PA"/>
        <property type="gene ID" value="ASIC002823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002823"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017588"/>
    <dbReference type="OMA" id="PYHIACF"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000171">
        <property type="entry name" value="Dynamin-like 120 kDa protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045817">
        <property type="entry name" value="OPA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF67">
        <property type="entry name" value="DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19434">
        <property type="entry name" value="OPA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="316"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="927"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="991" mass="114657" checksum="63D264224512D487" modified="2014-10-29" version="1">MAQLLRGRSSIDPRFKHIRPVVYTVSRLNFSGFTTGNNGGPTGGTSGPGTAWSRYNYYRHQEFLRPPNASGWQYSHQHRNYGMLLGRVLRGVLKLRYLVLGGAIGGGVTLNKRYEEWKDGLPDMKWLEEVLPDNEKWANFTKSLLTVKDAVKDSIEIDPRLKQLSEHKINEWRQWFDQRLDNAIEAAETQQNPQIESSFQNLSEFISELYGATKEELRAKNTVNAKGLGAEESRKRVDSLQAQVDSLQTEIMNVQLKYQREVEKLEKENRDLRQQFLILKTNRKQPTKKRIKKSLIDMYSEVLDELSGYDTTYTTADHLPRVVVVGDQSSGKTSVLESIAQARIFPRGSGEMMTRAPVKVTLSEGPYHVAQFRDSEREYDLTKESDLAELRRDVEIRMRNSVRGGKTVSMDVISMTVKGPGLQRMVLVDLPGIISTQTVDMAPDTRDQIKHMTEHYMSNPNAIILCIQDGSVDAERSNVTDLVSQCDALGKRTIFVLTKVDLAEDLADPNRIRKILSGKLFPMKALGYFAVVTGRGRKDDSIETIREYEEKFFKNSKLFQSGVTMSHQVTTRNLSLAVADRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFEKAKGEVLDEVVNLSQVSAKKWEELLNSKLWEKLSSYVFENVYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQEEFQHLMEVARKTPDHDDLYDNLKSAVIDEAIRRHSWEDKAIDMLRVIQLNTLEDRSVHDKQEWDQAVRFFETSVKEKLQTTEKTIAEMFGPSTSQKWLQWRSSTEEQNKRRQVKGELDKILDSDTKHSPTLSYDELTTVRKNLQRSNVEVETDYIRETWYPIYRRHFLKQALNRAYDCRKAYYLYSQQGNDCEINCSDVVLFWRIQQVIKVTANALRQQVINREARRLDKEIKEVLDEYGEDDEKKQQLLTGKRVQLAEELIRVRQIQEKLEEFINALNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDL9</accession>
    <name>A0A084VDL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Monocarboxylate transporter 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003092</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003092-RA">
        <property type="protein sequence ID" value="ASIC003092-PA"/>
        <property type="gene ID" value="ASIC003092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003092"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="7451BAC0FEE1DA90" modified="2014-10-29" version="1">MWGAFVDARVFPTNINNSIVVTLNHLSDGFGIPSSGPFARGMEAGGRVRSPGGWWVQQVTINASASNIIIITAVRQIIPIHIRYKNRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEG2</accession>
    <name>A0A084VEG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00003516</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01012277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEG2"/>
    <dbReference type="STRING" id="74873.A0A084VEG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003516-RA">
        <property type="protein sequence ID" value="ASIC003516-PA"/>
        <property type="gene ID" value="ASIC003516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013427"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="31919" checksum="411C46A8D98B2A38" modified="2014-10-29" version="1">MGNTVSAAEKVASNIIPNTLLKDEPAALPKGHPHIGDASAMAGNPPPECPMHQKQQQPKEQPVLVSECPVKHDGAEVNPLNMMPPANQNPSPGQPFPLPTDRQVSSIPKATADGKREFWVYPSQQMFWNAMLRKGWRWEKDDIAPKDMDDIIKIHNANNEQAWQEVLKWEALHARECGNPRLKSFGGKATDFSPRAKIRNMMGYELPFDRHDWIIDRCGKDVRYIIDYYDGGMVDEKYKFALLDVRPAMDSFENVWDRMTVAYMRWKFELEDKLKELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEG8</accession>
    <name>A0A084VEG8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="16">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00003523</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for the coordination of mitotic progression, and also plays a role in cell migration.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="16"/>
    <dbReference type="EMBL" id="ATLV01012277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEG8"/>
    <dbReference type="STRING" id="74873.A0A084VEG8"/>
    <dbReference type="MEROPS" id="M08.002"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003523-RA">
        <property type="protein sequence ID" value="ASIC003523-PA"/>
        <property type="gene ID" value="ASIC003523"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003523"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010839"/>
    <dbReference type="OMA" id="MVRHHVH"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000001">
        <property type="entry name" value="Leishmanolysin like peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000004">
        <property type="entry name" value="Leishmanolysin-like peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="14">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003523-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="710" mass="80550" checksum="ADB96CC69C130C44" modified="2014-10-29" version="1">MFCRNIWLAKLTGSGPNYRPQKICRKILLAQVERNLLQINFFHTGITAACKTFAKRTNVTQRLKFRSVALASSQLAPVHVIHGVQLEPHHVIRKRSIDQPLRILIVYDESVYRLDTDKFSLINNTILPEAVRFWEQALMVRQTKEIIRLNRKCESSQVFVKNSMTYCIDSCKPITLCGEVQVPPDHLDVCRVCNSTGQDCHEDPNTTAGSGISNADFVFYVSALQSERCHKGLTVAYAAHCQQEAGLDRPIAGHANLCPDSISTKPQELQTLLSTVKHEILHALGFSVSLYAFFRNDDGSPRTPRKPDTGKPYLNEKFQIHQWSDETIRKVVRTDWAVRDGTINRTIDMFVTPRVVKEVRDHFNCQKLEGAELEDQGGEGTALTHWEKRVLENEAMTGTHTQSSAFSRITLALMEDSGWYRANYSMASPLTWGRNLGCNFAMRSCKEWITSNTLKGRSIHPFCAKVKRDPLQTECTDDRSSVALCNLVRHVAPLPTQYQNFDSLAHVPVGEEGFYGGSVSLADHCPYIQEFTWRSKNVVVRGSQCQFEDNNPKPEKNFALESYGPNSKCFDHSENMWEERSCRQTREWQHWGSGCYQYRCDHGRLHIMIANKSYECFFAGQKLNVQLMAEGWLHRGAVICPSCKDVCNSVFERRGERCKVSEDAPPDSFYPRDELKCSGASTPHIRGLLSSFVLLTMAFTASTSVSRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEV4</accession>
    <name>A0A084VEV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Hyaluronan and proteoglycan link protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003638</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524781">
        <property type="protein sequence ID" value="KFB36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003638-RA">
        <property type="protein sequence ID" value="ASIC003638-PA"/>
        <property type="gene ID" value="ASIC003638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003638"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="8261" checksum="F37D3B47BF393B69" modified="2014-10-29" version="1">MVLKGWETVWRCWENGVDWTVASLWRLTLAGQLPLELLKRMCRKEVTAYGLRKAVQKLLAIRADERRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF71</accession>
    <name>A0A084VF71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007674-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF71"/>
    <dbReference type="STRING" id="74873.A0A084VF71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003814-RA">
        <property type="protein sequence ID" value="ASIC003814-PA"/>
        <property type="gene ID" value="ASIC003814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003814"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020213"/>
    <dbReference type="OMA" id="GFANIGP"/>
    <dbReference type="OrthoDB" id="6509831at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000097">
        <property type="entry name" value="PDZ domain-containing protein GIPC1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF1">
        <property type="entry name" value="GH21964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038083">
        <property type="entry name" value="UCP038083_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="38673" checksum="544663B2FC99F28E" modified="2014-10-29" version="1">MPLFNKKSTKISNPSPPMTKDPHHPAFHDNNNYKNHPIPTAPTIQHHHHHHDSMSTNGGGAGLGESTVTKPQLVFNCQLAHGSPTGFITGFASVKELYQKIAECYDFPMDEILFCTLNSHKVDMSNLLGGQIGLNDFIFAHKKGRPKEVEIVKSEDALGLTITDNGAGYAFIKRIKSGSVIDRIQHIQIGDHIEKLDGINVVGKRHYEVARMLKDIPTGSTFTIRLVEPMKSGFQGIAPRKGTAGSKPGKQGYGSGKETLRFKANGNAAIEDEHDDATQSGIDAINSLLDSFMGINDSELATQIWDLGSNKINSMDFAEAIDASDLEAFGFTDDFIIELWGAITDARQGRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFL0</accession>
    <name>A0A084VFL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003911-RA">
        <property type="protein sequence ID" value="ASIC003911-PA"/>
        <property type="gene ID" value="ASIC003911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003911"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020190"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14229" checksum="B84767F92EDBFB99" modified="2014-10-29" version="1">MSNFMDLAAPTVAMAGKEIQETYFTVVNGVCTTPVVSRTRVRNTPSRVTFTTPGRRVLTGGAWAEEAAVAVVALVERRDIEVETVYEPSGLSGGRRQQQQQLPQKEEDEEEEEEEEKKKVTTRGGEGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFZ1</accession>
    <name>A0A084VFZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001566-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012584">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VFZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004053-RA">
        <property type="protein sequence ID" value="ASIC004053-PA"/>
        <property type="gene ID" value="ASIC004053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004053"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002870"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005650"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012947"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016824"/>
    <dbReference type="OMA" id="GIVNWFR"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 central region" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="2962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1600"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2478"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2964"/>
            <end position="2996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3017"/>
            <end position="3067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3139"/>
            <end position="3191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2964"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3025"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3140"/>
            <end position="3151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3168"/>
            <end position="3189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3328" mass="369062" checksum="AFA58ACB516F3EE3" modified="2014-10-29" version="1">MANASSNNPIDEGLQDLGVPVPVQTFLWQQIAPFIRPKLGKLHEASCMELKEACKSFEKVLVQNIQFGLSPSLTSALESIPRWRIVQAALPHVIHCAGALMHNRVKDLQALGSAETKILYTLHWILLFAAEECADAEADKDSTSSNYLFSIPTISLFVFLFAPIAHMLKESDFQNFRLENGLKMWQGMWEYRAPNAPCFTAPVKPKARNLLTSVSTTPSPEVFSPKPDXXXXXXXNENIESPPSIYSGNLKHDDELSFVSSPKDSVFPETIPEEASSVEEERVVIFRLPMDGGVPDPSYYTADASLLHHGAGKFAKPAAHQTPTSSGGVKPHPLHHSEHRGEATSFDFDKIDTYSKDSKPKTSSSTERESFDTGPQMSQGQKCDVVAATFLDVAVLRCLFISHWQEEGVYWSLHYLYNRLRDISEETSVLPSHPRRRSNSLPIPQIEISLYQGPTSSRDSPSIGSANKDYIEIPEPPIPTLLADAPFYVPKSSSAAPLEDSSLAGSLGERKGSEKKRRVKMADLRTLIETRILSKSDRGLEKIGLDANTNGKRLQQMECHRSLDTGERQLSRSASMISRAPSTNLVKGKSMPSLRCHRIIEPPPKVIRNVQSSTQSRQSSTTPKYPIITVTEHTPTPSPDYMKRQGSIDSQLDAISAGGSTGMFKSQMLRSHTDSHIGYTSASDETEAPGSCFYITKEGTIDYEVVLLAVHCIFKRDSGVCTLRVLEAGLNICEILMDLGVLKFGDHAHSLTIGIVKRAFMHLGCPHGCNDANRGPPAEVLRTTCNSILSRLLRQNGKILKSNLRSFIKESPLHEITDFFHAYLGFCVDPSSLLSPLNHKRSSGIKSLNPDFGGIPGGQGGYATNFGSGLTGGTESQLIGAIFKTLTSRLVQSLKELKSQENLALYCDVRQLITYVKGAHGGPFRVVALSGILAVTPRPHKQAPNMQTTRVIRHLPTNDIHLLQQDEKAQRKLLFKKKSTSSTCVLLETEGFEEPCRASQSPLSNLRRKGPQVRPTLTPRHSERALLSDSTSSSERNSVGRLTGIVRWFRRSKDRESVDLESGILAAAAASGSESMTSFMRKGSLNFQGRTRAADGIGRSIQKAKRRVERRLNRLGIGKGKKKTGGTEDVGGSYFSRRSSLDISDGPRESEVVVLKERRLIPTKPVREGMARFSLLLEVCAPGSVPDPALITALLDLPQAPIVARAAFLIECAHFVHLCNRGQWPSWMKHNLPSYRPSGPAIGPRSAMAAGTRRAHVLQRAAGKMFHQWGEALGARLNEMVNNEKQNSEQLAASLADPEKQKQLLQQDEEEDFLDETSVNPHGNDCPPALKLIACVLLLEITAFLRETYQTLPKASRMSTKEKHAPWDKVCRGETNRRWSMALSSMGHSQTSAQSLQSIAGQTERKISFVLQEPDNESENSSNTTLTIQGEENVREGQKRTLATSRNFLLRRGTSATPAGGSFKRRSLKLRRGAKDLKEVENEYPVRRTDSIQSKRKVSSLSDRSDNSEPGQISGGEESPGILSDDQPPESPCDSNDTDETAKNLPWLKSVSNFLGSFHYYCDHQNFCHPYCYRRHMRAATKLIRAIRKVYGDEFGITPVTYAQPNESSKGATRRDRSKQGRKVSDQSSSQTSPSKRKDSVTKRDRIILQDESEPNTSQYSTFIHEPKHHQEDPPVLKYIKNQVRDVFHAPIASIVKGAAVLTEEQFVEVIPIAWELLLETDQEVSAASAALFILASVKAPNTATDIMQRSLKNKCPNTRIQAILRYQVLWKNRFQVWPRMEEGAHLSFKVPPPGIEFTLPSPKIGIESLPVVDPPWMPRQQNKDMEVTLNQERHRSLVTATKTRKKQQTEXXXXXXXIPITQQAAHEPGLDHGPTEDHVEEEEDGTRSAIHMHAAHSLFPSCLCSSVMQIVACLDDAAVNSDGCAVYEVAYQVIWICLVEDSALFLRYVLERLTRDHQDQMFKLLRHLIRFVPRLPQQAAFALYNYIIGYVMFYVRSTHECSQQLVGSALSVLWMVVHSVHGIMFKDLKQILRKEQCDASILLTANVPSAKKIIVHGPEDEGGIPSQFPVQEDTQFSQLLSESLDFFGIDEKKHAQHVLVDYKSHQILNPNWYVRDLYFFKRSQYPQLRLVEMKTEESFNALQRQELCKKFVEIGKVHLTWAILKNVDMVVQRVVFLHEELMKLPSFPRKALEVDLDLHQGGELGKELLGLDVLHKFMWVRLIARMFEAMAGNFAYSADIQLFLNVLSGAALLHSEDSCIMRYVTATFINAASNFKNIFSTNGYFMIMPAMLQVYSLHQTNKLVTTTIEYAVKQFYLLNRKPFILQMFGSVSAILDTDENGTYGEAHKVQSSCLFNLLLSLETPSPDPLNIAELVKEPKPLKAIDFCYHDEDEMVTVLDCITLCVMVVSYSAESTRGYQMLIILEAILPCYMQQIQSSSYIPLEGKCERDIILQLAVTIRTMVHNCEGLSKSYNGPFRNSPEHKGSSQRNCSRGPPCSPGLDYDDESHAKYVSDIGRTKMLNESVDDSETIREYRRPRDVLLSVVGEFIMQASTRLAELARKQGEAKPIELLDVKCHVRLAEIAHSLLKVSPYDRESMACRGLQRYMQCIFPRAEWADDHGMKPTLVTILRRLDKVFLKISKKSSVRRNTNWEAAAGLLKGVSEAIIRYPHILLWREMKALLTNVQNLIVNEPGNVPEGVSGAGAALMSKSPPAFFCSNVVRLVALQVVSPIDSLSHGLEQICGGSADFPTQEKAEGFLMHLLMPLCLKVCSGRGISDVGELKQSDISFLVTAVLNAMSPIAGRTAQAGMQMNRTGADLRAGSLTFTGSRDAKRPAKISSSLYQATFLALRVLCICFETRLSNDWPRIARVMRDLGRRNEAAPELWSFLEFVVTQRTPLYIVLMPFILHKISQPPIGDHERHMQFLIRERMRGTQPTGGTKSRGAILLELSRELRELREELETRRYDRDMSTETSKRDIPNLPTAPEQPVRHQHQRPSLISMLTGVQPPLNFPASLQQQQLQQDTRSSTGICTSSDTLSQHTLQAPKGESLSSSTTTTTNHRDGIGLMADSHSADLTLTSCTLAEAGSIDLQAATPAGSQGTIAGMGGGSVPHLSHSVSLQASAGKTQPPRLRFVSSVEFKTSSGETSTTPLSPDSLADDSSGENHNKHRLQRSRAQSRKTFRNRRGMRSNNFTEQNYIPTVAGGAGMAMVGLPPSGVVAGVSGVPPGVIVGGGTGGVVPGGGQPIPPIVNEPPFEPLNRAIATLGDLSWDSVSQTSSTSGYRDNYSLQTGLLSPDGSLSGNAMGGRSSSQHSLLMLFETQDEDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGP3</accession>
    <name>A0A084VGP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00004359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524836">
        <property type="protein sequence ID" value="KFB37137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004359-RA">
        <property type="protein sequence ID" value="ASIC004359-PA"/>
        <property type="gene ID" value="ASIC004359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004359"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011854"/>
    <dbReference type="OMA" id="CHQILRG"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF62">
        <property type="entry name" value="OTOPETRIN-LIKE A, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="389"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="591" mass="64114" checksum="D3064CE052875DC8" modified="2014-10-29" version="1">MVGGGEMKVATVDVESSDNMATLPVSRAHGVGGAGGAGSSDTAEKNNAANKEMELKNVMPKPLQRTSLFIVTSLVYAMLLIVVCVAYVISDVTTHRLPVIYYEGFFTYLYGASILFLLYVFCFLLQESSCCNGKPKPPKEKKPKKEKKSKKATDAEAGKDGKDERGKYVLHIISLRQESTPDPEAALSPRFKRKTTQDPAHGSFFLRVGAIAFGLGTMIYTGLEFGSFFEIPFTSPCHQILRGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVLARFGLMHIVATNICVWIRTLVLESLKEITAYHQRRGPEPEDSAILENIRQHTLRNAGMVMGTELGPGSDVEWEPISVNLNAQEDLLSQDASSVLSKIVQGTVHTLAEATTTLVTAASTPSTTTTTSTAAPTTTTSSTTTSTTTTTPLWTEQSTSTTGSTATSTTTTTARSFGGGFLDRLRDIVTTEVTTASTSYESPSEHFSTTDGVSVAGATNATTASIANPSYLDSLADHVNYLHRNSSLDQTYESLDALFPSAFIATSTAVSSNSTAVSCGRVNIMGTIVQDSAPYLYPFIIEYSLIGAAVIYVMWKHIGRYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH39</accession>
    <name>A0A084VH39_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004525</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524841">
        <property type="protein sequence ID" value="KFB37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004525-RA">
        <property type="protein sequence ID" value="ASIC004525-PA"/>
        <property type="gene ID" value="ASIC004525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004525"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="20041" checksum="4C73AF822F60AA3A" modified="2014-10-29" version="1">MGQRAYIAIRPNRDPAAPATAAAMAAVNEVNDRALNLRGHVLTARGAEKEAEPNSTTATGRLMPDVDQPADAIAIVRSNAMEAAAAAALNDGARTANNNPKMGSCSVCVCVFVRVATEVAVCRAVSFVRNIHTVSSVDATSTVSISASSSSSSYIAGRYVYIYGRRDNRCNHPRFGRCLGSTLLLLPCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHK2</accession>
    <name>A0A084VHK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004581-RA">
        <property type="protein sequence ID" value="ASIC004581-PA"/>
        <property type="gene ID" value="ASIC004581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004581"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004581-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6832" checksum="6A63D43E5002A8EE" modified="2014-10-29" version="1">MPHDWEWFQTLWQGRIQMSNRPIAVDYDRTHSRSIADDDASCGEPNAGIDDAVDDNLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHR9</accession>
    <name>A0A084VHR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP004471-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00004737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524845">
        <property type="protein sequence ID" value="KFB37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004737-RA">
        <property type="protein sequence ID" value="ASIC004737-PA"/>
        <property type="gene ID" value="ASIC004737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004737"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000618"/>
    <dbReference type="OMA" id="QHAKVNM"/>
    <dbReference type="OrthoDB" id="5960253at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB37513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="280" mass="32299" checksum="B8F4DBE03440614E" modified="2014-10-29" version="1">MEELSGVMIVLIIGGGVLGVTMCFIFAKRQIVRFTLRQRRGPHVAVGHDAKKSIKKEIERRLDCIQKIYYEPKLIWDDKLDDEKYILQPDTTLPPYYWRMKAVDDVKELEREITKQDGSQRHPRDSLRAFLLTTLAAPLNGSGQRLIHQFCDMYEHARHDPNEFGQEEYQAYQRLLKKLSEASKMLKSYSSSRKSSPNRTPVKKQSKMQSLLDPARLRPPPVALTTGGGTDTVMSNTRMNLSLAVQLQQQQQQQQQQQFQQHDLEENEILSISQYHGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIZ9</accession>
    <name>A0A084VIZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007278-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005111</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Neoptera</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC005111-PA"/>
        <property type="gene ID" value="ASIC005111"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS011088"/>
    <dbReference type="OrthoDB" id="7744420at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783444" evidence="2">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="158" mass="16696" checksum="18BCBBC631377182" modified="2014-10-29" version="1">MHSGTARSSGQPFTLALLVLTVVLAARIRAAPQADDQAKASRNNLLLRRGNVGRPLGRTTPTTTTTTTPSPADYAEDEYADNYDEGKGEDGGDDGGEEAGGKQPTTTTTTTEAPKKIRPSIRPFRSNDDLLSALKKRRQESKNNKPAAGKSIVAVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ03</accession>
    <name>A0A084VJ03_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">6-deoxyerythronolide-B synthase</fullName>
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        <name evidence="2" type="ORF">ZHAS_00005115</name>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ASIC005115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005115"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10709" checksum="AAE3B8A822205F4C" modified="2014-10-29" version="1">MTHSSSNAETTYPRCPGQTPPPPNPGVGRKILPECAAKPWVPLLDDRLNAFLVIPGSLLPSFSLHPVFKHVSDIRTKSKSNSGRSPNLLRDRQIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK37</accession>
    <name>A0A084VK37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00005701</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38331.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC005701-RA">
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        <property type="gene ID" value="ASIC005701"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS019563"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="213" mass="23491" checksum="0292038D7E00B1E3" modified="2014-10-29" version="1">MVYSSRDSSGNNYSLSTSFLASASYDPVTTPPTAATTTTATDTDMTSRTMTMVDETIVHDWQISSPXNGAGEGYGHRLPVSAPSSPSPRPHSGSWSTASGIESATEEFTVNQHYQHHQQENQVSDCYGDSFVRFGLPFVRSFSTPLSRWWSELQVCWFGSDLLAFLRWPKCGGKEPFRRSENECSTNGFPNAKIKAPLLGIFGRNGRRKCVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKS2</accession>
    <name>A0A084VKS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP009025-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005845</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKS2"/>
    <dbReference type="STRING" id="74873.A0A084VKS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005845-RA">
        <property type="protein sequence ID" value="ASIC005845-PA"/>
        <property type="gene ID" value="ASIC005845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005845"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000391"/>
    <dbReference type="OMA" id="QHHTHEN"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003565">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="481" mass="52865" checksum="8B2DDB333F5CE0C4" modified="2014-10-29" version="1">MEPTATAKSRQTASKTAVAAVQTVDMMENYSPSPVPAPVAHPPSPVPAYGIKLDSSAPATATPGRITAPPGCESSTAVSSSDCDNIVAVRSDPQASAEIFFALANNASENNTVYVDEIVGTIGEDGSAVCWQCKICPFSTSSKAEFLFHEILHSSKLDDKAKSSQSDPPDEAGRPRPSRPRPKLTCPLCGKAFSKASLRCHLRQHTDERLFPCPLCPMAFTRKANLKNHTDNIHHQRKSAASATVTSGEIAERGPHTPAPVESPSDLDSSTSTTTTTTDQPQPKQGSVCTTCGKTFANRHIMQLHSQVHLEQRLIKSFACQYEGCHYQAQSAADARRHLPSHSDERNFACSEDGCDYRGKSLAQLRRHALRHEDVRKKYKCDQCDFATRIPGHLRRHLLVHSGSKPYSCPHCDYSCNNIENLRKHVISTSKHKGKFLYECKLCQQPEADRIYGTNFQKEFKTHLQESHKLTAEEAAEACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL07</accession>
    <name>A0A084VL07_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase delta subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006101</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014395">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL07"/>
    <dbReference type="STRING" id="74873.A0A084VL07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006101-RA">
        <property type="protein sequence ID" value="ASIC006101-PA"/>
        <property type="gene ID" value="ASIC006101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020103"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000002">
        <property type="entry name" value="DNA polymerase delta small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000001">
        <property type="entry name" value="DNA polymerase delta subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="7">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="193"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="456" mass="51479" checksum="CA1296A0DA4CB4C4" modified="2014-10-29" version="1">MLFPEDKYLTNHPASEGRFERLKVPYQNKSDSFHFHAKDFSKQFAFIYASRLDEMLKLLENRVQQKWGDEIPIKRLADLREECPQKCVIIGTLFKHQELKPSILKEISEENQLAPQPPRSHYTNDTDILILEDALQRIRLVGNIDVHSVVTGVVCAVMGYEESDGRFFVEDFIFYEGGMQKPLKPLESSPLLVLMSGLNQSAANDFSMSLELFQQWVFGNMEGFGHDHDWEAASIVRIVIAGNSVKASLKPKNHLQSKASNELASSELLSAVKAVDTLIYNLAQSVPVDLMPGEFDPANHMLPQQPMHHCLFPRSAEFTSFKGVPNPYSFEVADRVILGTAGQNAHDILRYSKLETPMDALKATLRWSHIFPTAPDTLPCYPYYQKDPFIIKECPHVYFAGNAGEFATDVWNGTNGESVRLVCVPSFSENQSIAVVNLRTMECKKVSFKIEAIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLQ2</accession>
    <name>A0A084VLQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006212</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLQ2"/>
    <dbReference type="STRING" id="74873.A0A084VLQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006212-RA">
        <property type="protein sequence ID" value="ASIC006212-PA"/>
        <property type="gene ID" value="ASIC006212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006212"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002050"/>
    <dbReference type="OMA" id="RETMFHR"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="39147" checksum="9FB0B7755EC3A5A1" modified="2014-10-29" version="1">MLLAKGPAMAAIDSDMEETEPDEDVGSESEESGFSEETEDDSDDALRELFLKNKLKPGLNVIQKVSQEAVNEEEKLKTALEMITLKAPWLERMDLVNDLAPLTPELAIQIEKHEQKRENQFKGNRKIPYVAPELDPVLNEFKREILFHRQAQAATIEGIRRLHELGVATKRPSDFFAEMAKSDDHMQRITKVLQDKQEGIAKSERMRQLREQRRIGKLIQRQATEKRDEERRKMLSDVKKFRKGKLANLDFLDGDGDDDEGPRGEFRKSGKPKPSKKQAAKLSGKRKARDAKFGFGGRKKGMKRNTRESCIDEGKRKKGPAGGKGGAAKKRPGKSRRSQGKSQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLY3</accession>
    <name>A0A084VLY3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006516</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLY3"/>
    <dbReference type="SMR" id="A0A084VLY3"/>
    <dbReference type="STRING" id="74873.A0A084VLY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006516-RA">
        <property type="protein sequence ID" value="ASIC006516-PA"/>
        <property type="gene ID" value="ASIC006516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002883"/>
    <dbReference type="OMA" id="GYCDNAK"/>
    <dbReference type="OrthoDB" id="8179031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783560" description="Hemolymph juvenile hormone binding protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27274" checksum="BE6FE98CFF3BDE8D" modified="2014-10-29" version="1">MLAVVVLFACLGGSFSAIPPYIKVCSRNDPELSRCIIESVNDLKPRLATGKISGDFQIPPLEPLALSTVNMDRGAEFKATFSDLIVSGASKFRIDNLQANLETLIFDFNIFLPKLTFKGKYDLKIKLLFLNVAGAGDLTGQTENIYARVKVVCEKYIKNGKEYIRVKKQLVRIQIENGQFDLKDLFRKDPVLSQVGNQFINENSRLFLDELTPGLERSLAETFRKMANEIIQHSSFEELYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMB6</accession>
    <name>A0A084VMB6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006437</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMB6"/>
    <dbReference type="STRING" id="74873.A0A084VMB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006437-RA">
        <property type="protein sequence ID" value="ASIC006437-PA"/>
        <property type="gene ID" value="ASIC006437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006437"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011023"/>
    <dbReference type="OMA" id="TNIVGHK"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="142"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="412" mass="48359" checksum="2F1C6E9A277E31AC" modified="2014-10-29" version="1">MEEIEIEPPNATVPVSDQYPEEIERIASDELTYAEFFNRYFRPNHPVIITSIAKDWECYNKWINRTENIPPTLDVAYLKARLPNVPVPVADCAKQYYNSHEKVELQLHDFLNTWACFENEETTQTELPTKRSRYYLKDWHLQSTVPEYCFYQTPRFFASDWLNEYLVETGADDYRFVYMGPKGTWTGFHADVFGSYSWSVNVFGQKLWYLLLPGEERKLLDSLNNLPFMITETLLHEVDAKFYTIRQRPGEAIFVPSGWYHQVQNVEDAISVNHNWFNGCNVGLIWRNLCDALRDVRREIDDCRDMDNFEEHCQLMLKASFGMDFEDFLTIIFYICDKRLASFLGGTKDRQFSTYELGKRHAEFDLKAIQHLLSGIVEGNHLAFCPDLFSNAMNWLNKVKSIEISFQSNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMI3</accession>
    <name>A0A084VMI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006514</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006514-RA">
        <property type="protein sequence ID" value="ASIC006514-PA"/>
        <property type="gene ID" value="ASIC006514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006514"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11411" checksum="0CD94CD3A3E51472" modified="2014-10-29" version="1">MFHKSFKFKDGQRLSFRNPSCNHMVHGSGPSFGANFTSVTPARLLRYGTDKNFEALAGNEPNRVKSESFTMSVQATAIGQLCAERHHRRQQRDGVIDRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN67</accession>
    <name>A0A084VN67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006836</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014700">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524979">
        <property type="protein sequence ID" value="KFB39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006836-RA">
        <property type="protein sequence ID" value="ASIC006836-PA"/>
        <property type="gene ID" value="ASIC006836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006836"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="11061" checksum="A46BB17DAE498E3E" modified="2014-10-29" version="1">MPPVRSLLCRRPLPPQGVVEKLFLSSGVEKMGEKNLPVGSSRERGKTKMEDRFGVIIQCRSKSTPKSRLLGRVPEQEYGTILHRQQLEHHPMHLDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNI1</accession>
    <name>A0A084VNI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">ABC transporter G family member 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006867</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006867-RA">
        <property type="protein sequence ID" value="ASIC006867-PA"/>
        <property type="gene ID" value="ASIC006867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006867"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="24459" checksum="0322172A456498A7" modified="2014-10-29" version="1">MPECVCVWVRMLQKQRCTRAPVCVASLPFEPDSSSSAIASRCGLVPLLTLVLLVVLVVLVVASASTCSSGRWSPAVGRARSRAIAREHQSHTVAPGRPRPHIGPRASAGSFRLCRALCRRSIAGAGPTTDRPTGSLPATVRYGSPTRTPGSVGRLTSSPPFAPFRQTPGRFASLLVCAIFKYLREHAETAPSSPGTAPVGECEVEGAAGGRRWWRSCDARFTNKQANLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNT0</accession>
    <name>A0A084VNT0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Sensory box/GGDEF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007075</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524994">
        <property type="protein sequence ID" value="KFB39624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNT0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007075-RA">
        <property type="protein sequence ID" value="ASIC007075-PA"/>
        <property type="gene ID" value="ASIC007075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007075"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007075-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11526" checksum="A4C1B9AF416957D3" modified="2014-10-29" version="1">MSPEDVGRSPVTFLAAFCVAFSSRVSNPLRWEATDANQCLRISNLTTIDVIVSNPTADTNEKTKPVDDDGVDECSVELPVAANDGKTFGDLCQYVTGWSRSRPKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ55</accession>
    <name>A0A084VQ55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007631</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007631-RA">
        <property type="protein sequence ID" value="ASIC007631-PA"/>
        <property type="gene ID" value="ASIC007631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007631"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8606" checksum="DA04BC046BEF1A6E" modified="2014-10-29" version="1">MVMVDVGVVCRSEQRLRTVSMGHCCPAATPGCCLAAASRYVWFLERSAFRDRAVLQLMQGPGCLAQIEQEQEEQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ59</accession>
    <name>A0A084VQ59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007635</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015137">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007635-RA">
        <property type="protein sequence ID" value="ASIC007635-PA"/>
        <property type="gene ID" value="ASIC007635"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007635"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007635-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="16837" checksum="F6ECE739CC41661D" modified="2014-10-29" version="1">MRQAPSMRLLTYASEAPSTKPDVFTAIRQVPDRMRKASAPGTTGGVKVQQSKPTNHRVKTNHHHQHLHMAHRHPSRSFGLEVVDRLETRSLVPSCAVVPFASILSTAVLCLLASPKFQTKSYRDCVEEHAVWSAEGGEDGGNISTGFPQKVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ66</accession>
    <name>A0A084VQ66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3736 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007643</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ66"/>
    <dbReference type="STRING" id="74873.A0A084VQ66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007643-RA">
        <property type="protein sequence ID" value="ASIC007643-PA"/>
        <property type="gene ID" value="ASIC007643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007643"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021001"/>
    <dbReference type="OMA" id="GRVDNMH"/>
    <dbReference type="OrthoDB" id="5955164at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007643-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="39185" checksum="758D73B847674B7D" modified="2014-10-29" version="1">MDFPDTLKIPIGKGLAPQAGAIVNGAPVVGSHSLSGEQGAGYVTEKLYMLLQLYLQNKGWNPSVELLQCFAELKDTPILPSASYLQTLASRVALDNQGRLVLRESGKIVLPYEHFANAVMLKHMSGPHGLHLSIEATVRAVMDSYTIGRDSFGMEKEFIVEVVQSCPSPACRYYKGQIGVGPYIDQATFANPGAHLNTEYLSHLQHQNASAMELGSANENAPKALMSQTVNMDTGHKLSDYMRGAVDPHENVSSASSELLALHNGAWNQERDGLVVSQEKIIRAFSELMRNISKMKTFIRPSMCKPYGKQSESLQKTLFDTIQLLQMLRNCLPAPHIPVVSWKSDPIISGSNSEAAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQJ6</accession>
    <name>A0A084VQJ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00007619</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01015218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VQJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007619-RA">
        <property type="protein sequence ID" value="ASIC007619-PA"/>
        <property type="gene ID" value="ASIC007619"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007619"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002180"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014097"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015299"/>
    <dbReference type="OMA" id="AFECHFT"/>
    <dbReference type="OrthoDB" id="10065496at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05170">
        <property type="entry name" value="PIKKc_SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039414">
        <property type="entry name" value="SMG1_PIKKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF119">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2051"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="3312"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3247"/>
            <end position="3289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2459"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3250"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3279"/>
            <end position="3288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB40240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007619-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3344" mass="372979" checksum="F48492C2D79AC8D7" modified="2014-10-29" version="1">MSSKPGPKRRHEVETSMGRKGEAKPQRTTGGGSSGGGRGGGNGGGNLSRRAKKRANEQQKLRANAARTASGGGGEDEGTTPIMTSSKRYQSSRQQSATQKRDRSRKLFGEGIAGEGVTRAGTEGLSVGELALANLPEDMRISRLLRRLASEQSVRGCLDLCERLQLVILDPPNSSYVRKSFELLSNTLVPILETGPRECHDRIAQLFGMMLYVVVSGSHDLTPFRNWTCKWLWQTNRLRHSMLVALRQALVLDRHGDLQLEPVVGELLGELQKLLEETDGPDIFVLVTDIMVGLSAAYPESFEPYFKDVVDIVVGWQLETAQSNGLKLHCARVLQAFQPYWLEQREVTLSLLDQFVEDIQGCWDELDDDDREQWRTAQRLSATLLTAFNSVFKCLHVDSGVLASGRRPTLGGGFDLGPEDRALFESAYARIMVILSTLLEAPTSELPLAAISEFLMLRLSLGGLADAHAEILAVIEHLLDRAASYSDAQLGSLLHLLLRYVETDGSEQQQFTMALLPLIMRVNAGGFYAVRFRRSKPIQQALLVLYHRMLTFKNVALLQSAYGLVLDDLDDALAQLRRQAVGCAHHQQAQYRISFNLLVLSPLAMARNSIFITWTLQERPVLHVLLERLALLDGKLWACHGQLHHAVLLVAYHHCTANNNFVSSSNLLQAKSYGGTVDRFLRLQQDQRQTSGSDAVPSASPTADHFGLVLRFLGTLLGEWTVLAATEGVSGSGQGSEAGRDKLLELLLDWCLAIVTQTERYHDVLQECADFNRLLTLVCTVSVDRGSASERIGLRCASCLDAVCQYASLHPAVYQAIAETCCVHLCSVYGSLRTRYTVIFSRLPLRHSLRQVNAFTGANRRRREEIRELKNVLYQSTSTELRHQQSAVLRMADLRALLNRVAFARDGPAYVGEYLHELLTRSYNQPSAYGEMALRDLRCLIPWAQWEAAQLCVNHKLRTPFGKPQATFLRIESIVKQCARILALSDRFPVRDIRTSIANQRHARILLGFLEALEKSIYNAAEGTAYALPAPEKPARTFFRVNAPTCAEWFTRIRTAVDLVALHCMEPEMVIRYSEAVLRELVTAGKTSDLIFEHMLMSLVWALLRNWESDALYGVYVWSKQLTGRKYTWIRMAAEEAAGHRETAAEGFRAILADPAGAGMDRHIRDFIVDQTILSLLFTGDYRQLYEFLRAEETGGTPRATIPLITITAEQIHSIIRYEETHDVSVIDISQWELVDVGVDIPNDFSCHKMICAVENSLSGIILQEQIEQRERMIEASTELIQCYLQECLLTKCHEYLFQLTITNHILYKIAQRTRQAQANASATESGPLRYDDGIGTLSVEKFYGTLTLMRLLAWSEFLLANGNGGTGYEGEQQNIDLRLDMVSIGRKEKNYALCRRELEKYYXXXXXXXPPRPRPRVSCGPTRICRPGKRLEAIDFAASAATAINDALTALSDGETVAGARLERLDERTARFMLTLGDWLSSACGSESGELSQAALQLDSVQRLGARLPAIDSKPLAPDHAAQLGACDVLVGSLMQGASNRCPSLAKAWFQLGSWLYRWGKRVVELSSGASSARISVEQVAAILTDPLVTQADCERIVAILNEHEPGRTGDERVDDLTEDGELDLDSSATIGSIGLYEALQSALPSLARHVPPERLHAIIDVWRSNHRAVYGYYEAAAAAYFRFLQLSTLSPRASGPADDGTDSERARSVTVTLRLLRLIVKHALGLKEVLEEGLATTPSEPWRVITPQLFSRLAHHEPYVRRRVSELLCRVAKDAPHLIIFPAVVGSVHEEQPELTNVVNVLLEGGADADGTAPSPAAPAPASGLAFCFNALLDILSRVVPDTVKQVQTLVHELRRISLLWEELWLVSLQQIYADYGKRVAAFESAYARQHAAGQLAEPRRALLAEKHRLLLRPLIFVLEQLYAITSRAPETNHERHFQERYHRYIRSMLEKLRAPADFSRPIEGWERFRALYTQLQTRSQKRFAFFLRLADVSPNLQQLSHTAIAMPGIDTTTVTTGGISAGGGPAGCTGPDANGGHVHRQSILIRSVDGTIQILPTKTRPKKLLFHGNDGRRYGYLSKGLEDLHLDERIMQFLSIANLMMTSSIDCNGNVTHYRAEHYSVIPLGPRSGLITWVDNTVPIFSLYKKWQQREALQLKENKESGGGGGKHGGGGGGGVLRPSELFYQKLNPLLHSHGMKSSDSRRDWPLAALKQVLAELQQATPRDLLAKELWCHSATASSWRQVVRTYTLSLAVMSVIGYIIGLGDRHLDNVLVKLATGEIVHIDYNVCFEKGKTLRVPEKVPFRMTPNLEEALGMTGIEGTFRLACEHVLKSLKKGRETLLTLLEAFVYDPLVDWAISEEAAGGVPMTATEITVSTMTAATGPVAVTGTTGGVTAMAVSSLATTPATSSAASKYISQAKQQLDREVTRDTLAVRFAECRVDWQQNRDELLQHLLSLQKLLADQQAVRGELREAEQLRSSLSQQLQLIGEAEYLDTAFGSHPLATLAHRLSVRARVQEEYGATRDLLAGQAERLRRYGGQYDEFRRTFRADRLAQLRREVSKAHWQLPEHSPRLIAFLAVQPGDDGQPSENVGYVRYCCVRTELSELQRRAEPIAVRIVQLLGQYGELAEVLDTLQCIPPHTQCTMAHYTDWYTRLAQPDQNPSAALAALQQVQREQQEFLKGAVEAKDQLHQTFEEERTRRAETLLNRQNLLDRYSINYTPSAISDQTEAELQTLCELATQTVCFNNYHHGMNEVAASCTAILLYFATAQRIIVMNSNLLGVESFLLNDTSELSTHYVEKLWMLVRHIRQQLQSTLLPVRRFIVKVVRDRLAGRLPLAAARLIYESLPTAVESSIDETPHALEKLCRARCVGLLGTAVQFEDQLDQLKMVADRYNGLVLSGAGARRMDATNRCARQAHDQAQMRYDACVWMLHTALENSPGERERPTCALRRAVFLQQLRDATGSLETVRPLLQVAMEQLVGCSEVLRNRLAWATAAHPPLCPSELLAAFEQGTMRSVERVVACLRACELAVSHASAVLKFEETRIDRADSVLAKEFSGLLERWQKLLNNNGLRPTFVSPTEEALVELLDPEGSIDHTWIRNVRALIDDMTDQALTRIAQLEQESRTLRDAVLAAGRKLHTLTVSHNTIAGDIRALLRTQLRIGGSPALRDYLQRYRRFLDLLNNVREGLQDQQQTATTTPTSVTDGMLTKVDELIALLPDVFEQLFAFERLEDHQQLAVGALEEDAGPHTDPARQRATDSPTTGGGANDAQPLDRNQKQKEQKRNAYAVSVWRRIRMKLEGRDPDPARRYTIPEQVSWMIQEAMDPNNLAVLYEGWTPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQQ4</accession>
    <name>A0A084VQQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007783</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007783-RA">
        <property type="protein sequence ID" value="ASIC007783-PA"/>
        <property type="gene ID" value="ASIC007783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007783"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="22641" checksum="4C11AAE4BA093555" modified="2014-10-29" version="1">MREAYRATEMARHSFGTGVTVSVATGEPVGKTTSSTRSRIRRCDPWWKWRPAPVYPVCSDLRGGKRFHESEVLNLTVAYEGTYFTHVLHPGGRVFLLWPKPDHRILKVSCVCVRDPLFVPSTRKFTNHVRYPSVISDSSLLSSSWDLLRFHDVPKRYTFYHLERKARWVRSIVLPHATVSPVIRYQTTIGPISEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR03</accession>
    <name>A0A084VR03_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + L-cysteinyl-[protein] = S-hydroxy-L-cysteinyl-[protein] + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:67124"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:17193"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67125"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR03"/>
    <dbReference type="STRING" id="74873.A0A084VR03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007871-RA">
        <property type="protein sequence ID" value="ASIC007871-PA"/>
        <property type="gene ID" value="ASIC007871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007871"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006307"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013041"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022866"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1290.10:FF:000001">
        <property type="entry name" value="Sestrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="867" mass="99463" checksum="4C9714F544442FC4" modified="2014-10-29" version="1">MCTCFSLFLQYGSKNSPTDNSNLDHVTKVIAYHPRYLDHFLSTQKFVLQCDGPLPYDYRNYIAIMAAARHKCTYLVNLYEDVFLRNGGDPSWLNGLEHIPTKLRAISDINKILAHRPWLLNKGHIERLTKGQNSWSLSEVVHAIVLLAHYHSLSSFVFSCGLTQELDGISHKVIENNNVLTQKTAFNRLNDLYNSQHPDSHPQNGDDGNIRPEVTVDALMQRMKRLSEKNDEACSETELSNRFKHVEQQAAELPPVIREAPAEVPQQIGRYVDDPSFTYQDFARRGAENIPQTFRIQDYSWDDHGYSLVNRLYNDVGFYLDEKFRAAYNLTYYTIAGRTNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLDRSLKMFIKTACCFPERITKLDYDSVLVELQHSEKVVYSVEARQYTNMSARFQPKQEIDPEIPEPIVVFRYSNSPARKHESTDDHRVCLSLDWSRLQREAAADAHRAENISSPDANTITSSSEDTSAEGSRLQIACESEHSETMSHQSECSESSETMVSPVPTARRATIGSSEIQNLVPRTNGRISLRRWNTMIALENCEVPLVYHKNMARKFPVPARTPSQAEQRRRNTEAARLSRAKMKIAVMLMEKEQKELAEENIARKRLIAAKLVYANALRTLVGLPPSVHSESSEQSSQNQIQALAEQPGAAAETIDPENLIKHPLQHTWTLWYLELDRSKSWAESMNEVASFSTVEDFWSLYNHIRGPSEIKVGTDYMLFKSHIRPMWEDEANNRGGRWTVNMNKHLSDKYWLDTALCLIGESFEHSDDICGAIVNVRQKIDKISIWTANFQNREAVMDIGRTFKERLGLRAQIFYQNHKDTMIKSGSSTKATYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR71</accession>
    <name>A0A084VR71_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00007958</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525018">
        <property type="protein sequence ID" value="KFB40465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR71"/>
    <dbReference type="STRING" id="74873.A0A084VR71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007958-RA">
        <property type="protein sequence ID" value="ASIC007958-PA"/>
        <property type="gene ID" value="ASIC007958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007958"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010324"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="18">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB40465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="13647" checksum="25453DC3802781CB" modified="2014-10-29" version="1">MAFTLAAANKVFYDSANIRQVDVPSFSGAFGILPKHVPTLAVLKPGVVTVYENDGGLKKIFVSSGTVTVNEDASVQVLAEEAHPVEDLDSSACREILSNAQNQLSSASGDTDRAEAAIAVEVAEALVKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRR2</accession>
    <name>A0A084VRR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008272-RA">
        <property type="protein sequence ID" value="ASIC008272-PA"/>
        <property type="gene ID" value="ASIC008272"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008272"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010704"/>
    <dbReference type="OrthoDB" id="7743053at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008272-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="23818" checksum="44DBB20F9C25D1C8" modified="2014-10-29" version="1">MACKETTLALIEDYRKLPILWSKKHPLYKHRETRVKHLKFLAKKYCVKASVMEKRIHNLRSQFSREHKEHLKKTKPAFPRRPWYGYEKMLFLQDDWQGVAGTNTDESFDDLSDADAFDMDDDLDETKTPSVIDVTETKLIPIIDVEDDSSDSLSELEADDTTPTVSSSSTKQKEHANQFRDPHFKCKWQKQTGSAKTGRIRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRR8</accession>
    <name>A0A084VRR8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP001858-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008278</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRR8"/>
    <dbReference type="STRING" id="74873.A0A084VRR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008278-RA">
        <property type="protein sequence ID" value="ASIC008278-PA"/>
        <property type="gene ID" value="ASIC008278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008278"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016865"/>
    <dbReference type="OMA" id="WWKQFWL"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000891">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="762" mass="83337" checksum="B3DE4949D23671CF" modified="2014-10-29" version="1">MTNGQTKDSNLAHGLVRKVLNSSDGNGQKKPMVSLTHLPKRPPIDIQFIDMAYSVSEGHKRGYKTILKGINGKFRSGELTAIMGPSGAGKSTLMNILAGYKTSHLSGSVLINGKDRNLRKFRKLSCYIMQDDRLLPYLTVREAMMVSANLKLGKDISVSDKRAVVEEIIETLGLLDAASTLTLNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSATCSQLISLLKSLARGGRTIVCTIHQPSARIFELFDNLYVLAEGQCIYQGRVNGLVPFLASLGLECPSYHNPANYVMEVACGEHGDWNSKLVTAVSNGKCNNYNQPLAQSKSTSHKNMALDGNTTVPNDREDDLTLLKNSVTSNEYTAITMPGAPAPEAQLNNESKTGTTGSAGERKIPPPNGLSSGAEPSTTSITTTTTVSMASDATGPLLPPSATAGATATATSVAPPTALTTATSGQKATCTTSLLDSTESVSITIPKKQAGFPTSGWMQFWILLKRTMITIMRDQTLTQMRLLSHVIVGAIIGMIYYDIGNDASKIMSNAGCIFFTTMFTMFTAMMPTILTFPTEMAVFVREHLNYWYSLKSFYFAKTIADLPFQVLFTSVYVIVVYYLTSQPMEPKRVGMFVLICILTSLVAQSLGLLIGAGMSVETGVFLGPVSTIPIILFSGFFVNFDVIPSYLQWVTYVSYVRYGFEGAMVSVYGMEREKLACTEIYCHFRSPKKFLEEMSMDNAEYWIDATALFGFFISLRVIAYFVLRWKLHSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRT0</accession>
    <name>A0A084VRT0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP013305-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008292</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015775">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRT0"/>
    <dbReference type="STRING" id="74873.A0A084VRT0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008292-RA">
        <property type="protein sequence ID" value="ASIC008292-PA"/>
        <property type="gene ID" value="ASIC008292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008292"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008050"/>
    <dbReference type="OMA" id="HIHIVLA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="211" mass="23809" checksum="10CED613579471A1" modified="2014-10-29" version="1">MLLQVLATAFAIGISWVLVTVLRNRATIARMKKLLPHFNAVPSLPVLGTTYHFKDPTPEGIFATFSGFHRLYGRNLFTEGLFNQPGIQITDPKVIEQVVQARTIEKSTIYDFMVPWLSTGLVISIGAKWAQRRKIITPTFHFKILEDFLVIMNHQADVLIDKLKAHAGGPDFDVYEYVTYCALDIISESAMGVKLNTQQHPNAEYMQAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTR3</accession>
    <name>A0A084VTR3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008937</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016453">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525091">
        <property type="protein sequence ID" value="KFB41357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTR3"/>
    <dbReference type="STRING" id="74873.A0A084VTR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008937-RA">
        <property type="protein sequence ID" value="ASIC008937-PA"/>
        <property type="gene ID" value="ASIC008937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008937"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013828"/>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="29959" checksum="E090337769E7DD80" modified="2014-10-29" version="1">MIATKFGGILKSFGAVVKPYRLLSTYSQKDGVGTILLDNEKTRNSLSMEMMNSVLKNVVENQNHAELRCIVLAAKGHVFSAGHNLKELTAEHGADQHKQVFHKCSELIDAIRSAPIPIIAKVDGLAAAAGCQLVASCDMAICSDNSTFSTPGASFGIFCSTPGIAVVRAVPRMKAAYMLFTGLPISAAEALEAGLVSKVVSKDSLDEELDKICKAIASKSRSVIALGKKFFYEQMAMDVTTAYARGEQIMVDNLATVDGREGIKSFVEKRKPLWKHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTY6</accession>
    <name>A0A084VTY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009015</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009015-RA">
        <property type="protein sequence ID" value="ASIC009015-PA"/>
        <property type="gene ID" value="ASIC009015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009015"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009099"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="19568" checksum="54D8E3490F218FCF" modified="2014-10-29" version="1">MRARCNVSRRQRSEAAEEAVLRGLSIAATAGGGPDESVGVCGGSESVGGDAYRSTAHGARTRGRPRPRMALGLAVALLVTLLGVRGSEFPERECCDPVYPPMPDPDPVPPGAAHPTTTISSSSSFQTGQTGEEGGRGRDSGTALGGGDHGGGAGGPAGTGPGNHPSSSRPMHIGYSGEFSTNEGSLGNGFALLAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTZ3</accession>
    <name>A0A084VTZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VGCC_alpha2 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Voltage-gated calcium channel alpha2-delta subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009032</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016571">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525094">
        <property type="protein sequence ID" value="KFB41437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTZ3"/>
    <dbReference type="STRING" id="74873.A0A084VTZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009032-RA">
        <property type="protein sequence ID" value="ASIC009032-PA"/>
        <property type="gene ID" value="ASIC009032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009032"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022901"/>
    <dbReference type="OMA" id="RITIMDY"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-2/delta subunit conserved region" evidence="2">
        <location>
            <begin position="144"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="572" mass="64631" checksum="1F072E5E26660E48" modified="2014-10-29" version="1">MARPMVLYQADHPVHWSPVFMGGRSGVLGRESENRRKLVTTVSTPGNNWKVHPDWVYCEYNSLKDADGNGEGTAESTYRDKDESFDTPEEQMLHFLARVGRPGWKWMSLRPRSPQPHHGHGGIPVGHYAQHHFNSQGSRKAEPYYCDRTLVQSLVRDAIVTDGLDRAPSHPSRKEDRSRHGFSMFSVKTTFVATRSGLLRWIDHLPHSEDSTEPHFSETNARAMDMSWYKRAVDLYATEPEGFVFSVPFNSGYSGKNSSTLVTASHAIFIDHRGHKAPAAVVGLQFFARIPLQTFHQHHIQGWLFPCHLCRVGPVQIVPRLASQCTASTTCKKNCASDELDCYLLDDNGFVILSERSEHTGKFFGQIDGTIMDSLVQDRIYRRVPLMDYQGICSDRDNPYTGAGEPLKPVRPMSWLLQYFVSFATYWLSVLPTPIGALQHASYNYDGMEESDDEDTYDYEQPDYELPPEHSDVTTPDYEQRSTPTPQRSNLQAGPRVVPDPAHARPCDLKTDLYVLQPDRLNSSGQNNPLKGKLTNCHSSGCERPFSVQKIPNSNLILLVFTLTNCEHDCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVP0</accession>
    <name>A0A084VVP0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutathione synthetase</fullName>
            <shortName evidence="13">GSH-S</shortName>
            <ecNumber evidence="4 13">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00009615</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 13"/>
    <dbReference type="EMBL" id="ATLV01017200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVP0"/>
    <dbReference type="STRING" id="74873.A0A084VVP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009615-RA">
        <property type="protein sequence ID" value="ASIC009615-PA"/>
        <property type="gene ID" value="ASIC009615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009615"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016581"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021105"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.80:FF:000009">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000141">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000007">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="16">
        <location>
            <begin position="221"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="422"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="501" mass="55497" checksum="B0FB63C4A719C8DC" modified="2014-10-29" version="1">MCTSTPTLKSCIPFPLEEDQLVEVVEKAKDWAIMHGAAMRSKQDFNPDALQFAPFILTPSSFPRVEFQKAVNLQPVLNELIHAVAHDSAFLFDTLKSTVKVDDFTRSLIEIYRTVLDEGITQPVSLGLLRSDLMLETRCDNECSERVNPLNAYCCWKQVEINTIASGFGHLGPSSKYLQSYILTELGHRDKLVNLPENKALSGLCDAMVEAWKLQNRPDAAILFVVEDVTYNICDQRFHEFYIRSTYPHVPVVRRTLTEIHRAGRLGTDRELLLALKEGAPAVEMSVVYFRAGYEPGHYHGSDEWAARLLVERSRAIKCPSIQYHLAGTKKVQQALARPDVLRRFVGADDAKIDAIRDVFTGLYSLDPDEGGAEAVALANANPERFVLKPQREGGGNNVYGADIPTALDAMSPDERSAWILMERIFPPLSTGYMIRPGGPTPPPLVQLVSELGIFGAIIGTKDKILYNKQVGHMLRTKLSTANEGGVAAGLGALDSPYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVR6</accession>
    <name>A0A084VVR6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVR6"/>
    <dbReference type="STRING" id="74873.A0A084VVR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009643-RA">
        <property type="protein sequence ID" value="ASIC009643-PA"/>
        <property type="gene ID" value="ASIC009643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009643"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013920"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007430">
        <property type="term" value="P:terminal branching, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009643-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="348" mass="39732" checksum="FFFC5837C044BF85" modified="2014-10-29" version="1">MPGYMFNIDGGYLEGLCRGFKCGILKQADYLNLVQCETLEDLKLHLQGTDYGQFLANEPSPLAVSVIDDKLREKLVIEFQHMRNHAVEPLSTFLDYITYSYMIDNIILLITGTLHQRPISELIPKCHPLGSFEQMEAIHVAATPAELYNAVLVDTPLAPFFVDCISEQDLDEMNIEIIRNTLYKAYLEAFYDFCKNIGGTTADVMCEILAFEADRRAIIITINSFGTELSKDDRAKLYPRCGRMNPDGLAALARADDYEQVKAVAEYYAEYAALFDGSGNNPGDKTLEDKFYEHEVKLNMYGFMQQFHFGVFYSYLKLKEQECRNIVWIAECVAQKHRAKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVT3</accession>
    <name>A0A084VVT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002188-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009740</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525158">
        <property type="protein sequence ID" value="KFB42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVT3"/>
    <dbReference type="STRING" id="74873.A0A084VVT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009740-RA">
        <property type="protein sequence ID" value="ASIC009740-PA"/>
        <property type="gene ID" value="ASIC009740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009740"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783852" evidence="6">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="327" mass="37141" checksum="720D6D3E3369269B" modified="2014-10-29" version="1">MSSTGYRLAWLSIVVIGLQFTLNGGAQQLDPSKVSLDNGFYVLLGCARDLLVPDDLIALYQQRTFPDDSVTWCVFRCLGQRLGIYDDENGFNVDRQYERVKQRLTIDEATYKRGIRACIRREFEGRRLGDCEKAYISIQKCQGDTVNKAFKQELEEVKSFVTMLSNSMARVKQIPTTLPRIVLVALLALRGGSCALDFSKVTLDSTYYTILGCARDLYAPDDLVALYQLRIYPDEPITWCVFRCLGLRLGTYSDENGFNDALQYQRLKDSLTIDETTYRRGVRNCIQRETEGRVMGVCEKAYRILRGCQGGTIEGAHMQLLSQIRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVT6</accession>
    <name>A0A084VVT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Serine/threonine-protein kinase Nek9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009766</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009766-RA">
        <property type="protein sequence ID" value="ASIC009766-PA"/>
        <property type="gene ID" value="ASIC009766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009766"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009766-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13642" checksum="D45CAE87E6BF20DB" modified="2014-10-29" version="1">MGHSNRTLGTRDPDTSTPLCMCGVRLLKGRASVRCDDIIYKKSAVAYQSKLCHLPIPARQAANDRLGDGPKRDRIGPDRRIRATAAPEAPLRRVLHEFENEAHLRIRKIRFGVWCVRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW20</accession>
    <name>A0A084VW20_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor subfamily 2 group B member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00009829</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017380">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084VW20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009829-RA">
        <property type="protein sequence ID" value="ASIC009829-PA"/>
        <property type="gene ID" value="ASIC009829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009829"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007484"/>
    <dbReference type="OMA" id="DEHCRQE"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:nuclear steroid receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ultraspiracle, isoform B"/>
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    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retinoid X Receptor"/>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
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        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RETINOIDXR"/>
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        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="223"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00078913"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51843"/>
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        <source>
            <dbReference type="EMBL" id="KFB42164.1"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="479" mass="52459" checksum="370AF985FD4D1E51" modified="2014-10-29" version="1">MGPLSPPDLKPDLKPDISLLNGSGGGPFSPGNNCGNPGSPGSGSGVFNPVAVAVLQQQQQNALAVGAALGNGTAGGQQNLLVGGGGGGGGGQQQGSNGGGGGGGSGSNTPTNITQQYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLSYACREDKNCTIDKRQRNRCQYCRYQKCLACGMKREAVQEERQRSSKFSMKTEEINSTSSVRDVVVDRFLEAEQLGEQKSGDNAIPYLRVGPNSMIPPEYKGAVSHLCQMVNKQIYQLIEFARRLPNFTNLPREDQVTLLRSGWNEMLIASVAWRSMEYIETERAADGRNDGRVTIRQPQLMCLGPNFTLHRNSAQQAGVDSLFDRILCELAIKMKRLDVNRAELGILKAIILFNSDIRGLKCRKEIDQMREKIYACLDEYCKTQHPSEDGRFAQLLLRLPALRSISLKCIDHLNFLRLLGDKQLDNFIIEMLDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWK2</accession>
    <name>A0A084VWK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004004-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010039</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWK2"/>
    <dbReference type="STRING" id="74873.A0A084VWK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010039-RA">
        <property type="protein sequence ID" value="ASIC010039-PA"/>
        <property type="gene ID" value="ASIC010039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010039"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003990"/>
    <dbReference type="OMA" id="MSYNFEG"/>
    <dbReference type="OrthoDB" id="6340174at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF22">
        <property type="entry name" value="IP12060P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="25013" checksum="FF36EA04E46AE1C6" modified="2014-10-29" version="1">MFVRRSCFIVLGVYGLALVVGHTNPTADVVKSRQKRIVFPLNGAMGIIFAIAVPLGIPDRNIFMSYNFEGNYNSPADANIFTEGFGNYIKGIVEPLTAPSRPVESYGIRKRSVEKRDDQTPVTAQITRRQIYKMLRKQLKGQHFHGKKCLLRMICDAALHPFRETNGVIGDLVQIMLSPSTSMDENLPKEYLMAEVAGSNGSCDRYRTDCPKDPLEFVSFMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWK9</accession>
    <name>A0A084VWK9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Venom allergen-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00010050</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525180">
        <property type="protein sequence ID" value="KFB42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWK9"/>
    <dbReference type="STRING" id="74873.A0A084VWK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010050-RA">
        <property type="protein sequence ID" value="ASIC010050-PA"/>
        <property type="gene ID" value="ASIC010050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010050"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005617"/>
    <dbReference type="OMA" id="IWEHGPR"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000007">
        <property type="entry name" value="Venom allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784204" description="Venom allergen-1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="8">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="28516" checksum="E6803207435787CE" modified="2014-10-29" version="1">MFRFVLAIFSLVALIGSIESFDYCSNSLCNAGVPNVGCNPPPLGGGSRCFGMSPAVVTITSALQSRILDQHNRRRSTIATGGLFSFPQARRMATIQWDNELASQAGHNARSCTFAHDRCRNTEAFRWAGQNLAIKQFYGQTFTIEALIDEFVTMWWDEYQYTTTANIDSYPSNHVGPAIGHFTQMASDRTWKVGCAMQNWVEGGMWITYYFVCNYSFTNIINQPVYVRGTTASGCTTGQNPQYPGLCSLNEAIQSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX22</accession>
    <name>A0A084VX22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013055-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017837">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX22"/>
    <dbReference type="STRING" id="74873.A0A084VX22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010224-RA">
        <property type="protein sequence ID" value="ASIC010224-PA"/>
        <property type="gene ID" value="ASIC010224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010224"/>
    <dbReference type="OMA" id="QGHQAER"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF22">
        <property type="entry name" value="AGAP013055-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="593" mass="63802" checksum="C3F6A08B7A404585" modified="2014-10-29" version="1">MIIAIYHHHHPQPPHSTIHPHASSHRRPKQQAPPVDPNKKKTGKWNAMHVRIAWEIYHHQAKQNPDKAASIKTASEMLRPPSHMYPPSAAAAGLVRPHDLPSSTFPPAGLPGRPGPYDSAPLPPSYMSSPGSHIGVSPFGRYASPYGGSPFSGLSPFSRDIPIGSQMPGAMHDPWRSALPRSVGAYQQGPQPPGGAGWPPIKQDPGLVAENARREAEERERQREREERERERQRREREEREKQREREREEKLRKEQQERERERERERERERKEKERREMERREMERERMLHQQQRESKAAAAAAAAAAANAAAASINRDRSPLRNGTELDIRIKEEPRKDEELLMRSHAAAVASDPRYHPSMMPHPYMTGRHPAVHMLPGGHLSRTMLPPTMGLPTHFPPHGSWGPDPFRDYRLDSLHHPLRYNPLMDAYRAEEAKASLLYAAQTAAHFRGKEPSPVPPPQQQQQQPPPHHRMPSGPGGGGGGGGGGGGGPGGGNPGGGGGPPTGPGPGTPGGAGSGGGGGGGRDPSGGPHKAQSHPASATSNGPMPGAGGPGGGMGGPGGVSGPGSAGPPSAGSALPVSIDMHKKEDTCQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX89</accession>
    <name>A0A084VX89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP000659-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00010299</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017866">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VX89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010299-RA">
        <property type="protein sequence ID" value="ASIC010299-PA"/>
        <property type="gene ID" value="ASIC010299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010299"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009686"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011129"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019747"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023394"/>
    <dbReference type="OMA" id="NCTTVLY"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002352">
        <property type="entry name" value="Blast:Protein sidekick"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000231">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000236">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000301">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001132">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001362">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001549">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001715">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001722">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001849">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002022">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF46">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1999"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="242"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="340"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="434"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="525"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="621"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="732"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="834"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="945"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1268"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1370"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1468"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1569"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1676"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1787"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1882"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2099"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2111"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2136"/>
            <end position="2146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2190" mass="239999" checksum="E62CE051C69F4DC3" modified="2014-10-29" version="1">MLGRLFARLWDCARGEGVLLWEVKVLPSACAQTEKPSPAGGVEEGGDTQLQAPRFTTQPSSSGSIVNEGRTKILQCHALGYPQPNYRWLKDGVPVGNFSNSQYLKIQNVTREDAGKYQCQAENKAGTIFSDKTDVVVAYMGVFTDLSEKVVSVTSGYAAILNLSYIDSVPAPSVSWQTEEGPLSYDIKYAQTANNQLIILSADESDIRAYRARAINTQIGREEVTGYVRLNVTGSQHTEIAPEIIVHPRSMKVVRGAHMVALECIANARPLHELETIWLKDGIPIENTGITFAQTDPWNRTVALLHVNLTHTGEYTCQVQMRTGGHPIVFSMARVTVQEPPTFVTPLRTETLGEYGSRVVLACDVIGEPLPRITWFRNAAPIEQAAGKYAVQDDNSLEIYKLGMDDTAMFQCLASNEAGEKSAYTWLKVKTSTPIMEVPPGNQTVLDGKDATINCRAIAAPIPNITWIYNETLPIESSTRVQILDTGDLLLSNVRETDSGLYTCIRENEAGRIVASGFLTVLVRTQIIRPPDDMTVLLGHSASLECGVSSDPSVPYNIDWYREPNRLPIKNSQRIGVKGDGTLEITEVRPSDVGQYSCIVTSPGGNETRSARLSVIELPFAPSNVQAVRLSAPQHRAINVSWTPGFDGNSKLIKFIVQRREVPELGPLPDPLLNWITEAANVSAELRWILLTNLKAATAYQFRISAVNRVGEGSPSEPSNVVKLPQEAPSGPPVGFVGSARSSTEIIIQWQPPVEEHRNGQILGYIIRYRLFGYSASPWNYRNITNEAQRNYLIQELITWKDYVIQIAAYNNMGVGAYTDGAKIKTKEGIPEAPPTDVRVVALNSTAVRVWWTPPNPQQINGINQGYKLQAWRYERPPPPGGGGEMKVLTVPPNLLDPLAEQSEVMVGLEKYTAYNVTVLCFTDPGDGERSTPVPVRTLEDVPDEVSALQFSGISDREVNVTWEAPRRTNGILVGYQVRYYRKEHPEAARTVNLTAESRSLRVTHLTATTHYTFEVSGWTAVGVGPAKIATIQSGIEPVLPHPPYQLALSNIEAFSVVIQFTPGFDGNSSIARWIVEAQTARNLTWFVVHELHDPDASTVTVLGLTPFTSYRLRIIACNVVGRSEPSEPTKDFQTIQAPPKHPPFNVTVRAMSATELRVRWIPLQQTEWYGNPRGYNITYRNIQEGGPGEEEEAEQAAAATTTELATSAYGVRSVLIEDPTANSHVLDGLEEWSVYEIVMTAVNEVGVSADSSPHAFERTREAVPSSGPAVVEANATSSTTIVVRWHEVPKVHRNGQIEGYRVYYGSAVGRTRPVLHKTIANNYTFTATLTELKKFVQYDVQVLAYTRLGDGTLSTPPVRVQTFEDTPGAPSNVSFPDVSFSMARIIWDVPDEPNGEILAYRVTYLLNGSQSLNFTQEFPPSDRTFRATQLLAERYYLFSVTAQTRLGWGKTAAALVYTTNNRQLPQPPSAPQISRSQVQSEQITFSWTPGRDGFAPLRYYTVQLRENEGAWTSIPERVDPSVTSYTASGLRPHTHYIFRIRATNDLGPSSYSKESGQIRTLPAAPSEGITGLKVVPITTTSVRVQWSALRPAAWNGDAATGGYRILYQPLSDFPSTLQSTPKLDVPGVAQEAAVLTDLTQDRNYEIILQPYNSQGSGPPSPPVAVYVGEAVPIGEPLDIEGVAVSPTEVRLRWSPPRQNTQNGELLGYKIFYLVTDSPEGPPSPVATVPADPEEIEVVPASYNTHNLVFLDKYTEYRIQILAFNPAGDGPRSAPITVKTLAGLPGPPTHLLFGDITMNSLTVSWEAPRKRNGLILGYIVAYETTEDNEKFSKQVKQKVTGTSLVVQNLEEEVTYTFTVRAQTIDYGPAISGNVTTGPQDGSPGSPRELTIAKSQASVHLHWINGQSGKGPIQGYYIETKKRDDLRWETVARTTNGPLQEFTVSFQNLLPSTAYKFRVISYNRYGISCPVYSDDAVLTPSKLYLEYGYLQLKPFYRQTWFMVALAATSIVIVIMVVAVLCVKSKSYKYKQEVQKTLEESIAMSIDERQELALELYRSRHGLSANGGGGGGGLIGPGGGLGGGGGTGTMIHSTLGRRTGTILGRKGGGSGPGSSAAAAAASLGKSPPRPSPASVAYHSDEESLKCYDENPDDSSVTEKPSEVSSSDSQVSCCTKCVENIPDFVVLTEVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXK2</accession>
    <name>A0A084VXK2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Guanine deaminase</fullName>
            <shortName evidence="9">Guanase</shortName>
            <ecNumber evidence="3 9">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 9"/>
    <dbReference type="EMBL" id="ATLV01018085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXK2"/>
    <dbReference type="STRING" id="74873.A0A084VXK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010434-RA">
        <property type="protein sequence ID" value="ASIC010434-PA"/>
        <property type="gene ID" value="ASIC010434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010434"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021013"/>
    <dbReference type="OMA" id="CVHMNDS"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01303">
        <property type="entry name" value="GDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="62"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="461" mass="50626" checksum="07FC62255FEFDD88" modified="2014-10-29" version="1">MKQVFLGQIVHSKSLEELELYVDGFLAVSDGKIEAIGDRSQLSSLLPEAAQYAKVELSPSQFLLPGLIDCHIHAPQVPNIGLGLDKPLLEWLESYTFPLESNYRDAAFAERVYKYVVNNTIAHGTTTACYFASLYTETNKILVDEMLRQGQRGFVGKVSSNRMCPDFYIESCTEKSVEDNVDFIRYVMAKESDLVRPIVTPRFAITCDDKLMRALASLAEQYELNVQTHVSENLGEIETVKQQFPSAPHYVGVYDEVGLLTGKTVLAHGVHLEDAELEMLAARGTSIAHCPSSNTNLGSGFCDVRRLLEARVKVGLGTDVSGGSDMSILAAMRAALGVSQHLNFMKTQNVKGTGRVEARSDGKGKPYTPFSYNQVLYLATLGGAQALALDGKVGNFVAGKQFDALLIDTEPQPIGGYRLPEALAKEKSKTQLLLELVQKFVYVGDDRNILKVFVAGKQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXL8</accession>
    <name>A0A084VXL8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00010452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXL8"/>
    <dbReference type="STRING" id="74873.A0A084VXL8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010452-RA">
        <property type="protein sequence ID" value="ASIC010452-PA"/>
        <property type="gene ID" value="ASIC010452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010452"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000835"/>
    <dbReference type="OMA" id="GPFHIWL"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="242"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="394" mass="45269" checksum="F8B0DBF690956EF1" modified="2014-10-29" version="1">MLLIRHLRATAEILRISTRLGGTQTCLCSTQSKDTKNNHQKPEDGKSLILRTNLFESAAKKDKQTYIEMVKIFEKRSVHRRNHVEFIYAALRHMEEFGVNKDIAVYKALIDVMPKGKFIPTNIFQAEFMHYPRQQQCIIDLLEQMEDNGVMPDYEMEAMLVNVFGKKGHPVRKYWRMMYWMPKFKNLSPWLLPNPVPDDALELARLAVERMCSIDPRSQIDVFDTKTVENALDHTWVVSGQSLEQSELLEAHDKQEPVYIEGPFVIWLRNRSINYYVLKSAPKQLPPLETSGDPDDVSKLENPYIGLDLRFRKTKPSGSAVSTRRRSVHEQEDGIIYAICCTGSSTKDSLLSWIRLLEKEKGNAALASLAVLFKFTTPSAELLVPEEDSNKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYB2</accession>
    <name>A0A084VYB2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Activator 1 subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Replication factor C 38 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010829</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC2, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. Interacts with CNTD1; this interaction facilitates crossover formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYB2"/>
    <dbReference type="STRING" id="74873.A0A084VYB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010829-RA">
        <property type="protein sequence ID" value="ASIC010829-PA"/>
        <property type="gene ID" value="ASIC010829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010829"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023753"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="41147" checksum="2931903BD25692A7" modified="2014-10-29" version="1">MALWVDRYRPRELAKLDYHKTQANQLINLCSQGDFPHLMFYGPSGAGKKTRIICLLRELYGPGVERLRNEVMNFTTPSNKKIEIMTVSSNYHIEVNPSDVGIYDRVVITDMIKQIAQTQQIDPSGQREFKTIVLSEVDELTKDAQHALRRTMEKYVATCRLVLCVNSTSRIIPAVKSRCLGIRVSAPTEDEIIGIMNTICKKEGLHIPPELATRIAQKSERNLRRAILTLEACKVQQYPFTANQDIPDMDWQTYLRETANMIVQEQSPQRMEVVRERLYELLSQGIPPDIIFKGLVQILVKNCDMSLKTQTLGFAGLYDHRMQRGSKHIFHLEAFVAQFMALYKKFLNQVSVMDMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYQ7</accession>
    <name>A0A084VYQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Histone H1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010786</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYQ7"/>
    <dbReference type="STRING" id="74873.A0A084VYQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010786-RA">
        <property type="protein sequence ID" value="ASIC010786-PA"/>
        <property type="gene ID" value="ASIC010786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008206"/>
    <dbReference type="OMA" id="MCRMKWI"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22001">
        <property type="entry name" value="HMG-box_UBF1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF3">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="646" mass="73946" checksum="D4974B018F0026B4" modified="2014-10-29" version="1">MRPRSLSVAVDRHDIISKKFEGVASDENEEVVSDSDDPDDDEQAPEGKSDWTSADYKELLQHLRAVLPNSDKKKAASRLKSIEWSRVAFGNRSADEVKEVTCKLIEKVRKYRTLGEMLDDVSEKTSVIGVQKKPKYPPSAYNFYVKANLRTVKQEHPELSQHEILRKVAEQFKQLPDKKKQKYEQLAEQAKEEYKKELDKFYIENPDATPKKKTAATKKKAPKKPTKITPYNLFVYQKKLEGLTVSNADMKKLWEITDFEQKVKFIREAYSSEKSKLTKSEKDLLDIAHGKPEVVPRSTSEYFLKKYATKDPSIPPLSWRKGAMAEFRELPKIRKLELELELRRAQAEFVTKYRAYIEKLPLHEKQPEIDLLQQYLQTTMEKEQKLKYDGGDLTGCGGATSELTDLPLAESTTNDIEPRKKKSNKKVNASELPPPSPVAAKPLKSILKSPAPKHKLDEPEVSTTVSRKKKKSDPPVPVVESESDSYKKGKKKPKKEKDVNNGVDSDRGADKNGSNLNRFAVQEPKRPPKDIVKYYKKFHYFGKAGKHKESFEKLSAQRKKTIEEEMRAAQKKYMIDLKKYLDHLPKSEVKAYVTHLKEFVNNGSSADERETDEEEVEEPAQKSPAKKNTTKQEPSSGSSEDDSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZA7</accession>
    <name>A0A084VZA7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018663">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525245">
        <property type="protein sequence ID" value="KFB43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VZA7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011094-RA">
        <property type="protein sequence ID" value="ASIC011094-PA"/>
        <property type="gene ID" value="ASIC011094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011094"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019447"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="671" mass="70169" checksum="C4CB57101FDCC331" modified="2014-10-29" version="1">MFNDGKRFHQRGLFGESIGAGAPGQMPATMEKCFPYSILSKKQQLLTAGSSNGAIAKHPTSTALQSRVSVGPPLAAGYLTAGLPLAGKSSSNSTANVEPTLDAGGAGFYANAMVTDVGICFSMSNVSLNGEYHPPLGAIPPIAMSTAERRRSHEDPGPETALINARRRAGAFAPLTPNTVDGILHPHHIPGGGSSQTSLLPTQSFPVVPLAHQALHHHSTSSVSLQQLHHQQQQAASIVQPMRHPLPRQRSLVLPGKSAYGSTRTDVGPAGLMTSTGSSRSSPPYFKQPVGVGKINSICQPVTKATTLYPGPSVAHPLNRRVPLQYLPAAPQSQPTSLGLLPAASTPTAVALEYYRLAIEAAEAAGKRTVCEPEPGTVGKDGPSGAVPVLGVSGGSLVNYSADVEKLFTKCCYNNEVQPIPPPPQPSISGTVSLAPSPFQGNSPSPTSHTPPTLAPSHPALSRSCPTSPHAAPYAIPSGACPTLDILVHPEALSRPVEHEQLDEDEQPMEVCAEGEDNNDGDGDEPKDFSMKSVTGDGGQYTVHATTLPGGIGDGVGQVTNSGLHLGEDRGRRELKVAPKKKWIRHYMKGXXXXXXXTGLIPRHQSPQLPREALYCTPAGSSGCCSENTPLTCTTVDESVDDALVASLPLLPSRATFPPKATTGNECRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZX4</accession>
    <name>A0A084VZX4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003734-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019018">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZX4"/>
    <dbReference type="STRING" id="74873.A0A084VZX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011324-RA">
        <property type="protein sequence ID" value="ASIC011324-PA"/>
        <property type="gene ID" value="ASIC011324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011324"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021055"/>
    <dbReference type="OMA" id="TIECYFT"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="100"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="339" mass="38495" checksum="E90BA88EDCC9C19E" modified="2014-10-29" version="1">MTTLSHPFKDSPEPLEVPKEHAANVDALYEWIKEQPRFPAFTKNHAHLFLHACLWNVEDAKKALQKYSQIHANSPEIFDNRDIMSAGVQMTLNATHMVALPRTTPEGYRLLYYRLSDTDPSKMNFAEAVKSFCMFNDAQISVDGIMEGYIVIFDMKGVRLGHLARVQFGPLRVFMSYIQDAHPVRLKKIYIVHTASFINQVMALVKPLIRSELLGLLQFTATGPEEIVGVEYLPKDFGGPFEEVATMHAEQKKRLETEYRDWLLDSGALKEAPKQKNGSTSANSVKPPWRLHYCSVAYAMCFTGLPIPRRRQRKVGPKCADARVVHSSPRRTAPPRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W058</accession>
    <name>A0A084W058_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP001244-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W058"/>
    <dbReference type="STRING" id="74873.A0A084W058"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011540-RA">
        <property type="protein sequence ID" value="ASIC011540-PA"/>
        <property type="gene ID" value="ASIC011540"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011540"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018640"/>
    <dbReference type="OMA" id="HYNYHIC"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784159" evidence="6">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="212" mass="23265" checksum="192EF24145CC4C78" modified="2014-10-29" version="1">MKVLVVVCVVAFAVASATEENAIKSRMQPDAARLIDERQEKSTLSSLKKIVGGVSVSIEQYPYQLSLRNYDYHICGASIISNVWALTAAHCLYPDPDPKTISLRAGTSNQSRGGRIYNASRIIIHPMYNPSWMDNDVAVIRVSTPFSGPNTEQIRLVPQGFEPITGIRAIVTGWGRQSEDSTQVMTLAGVEIPIVDKEDCSSQWNGVEVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0A1</accession>
    <name>A0A084W0A1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001102-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011588</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W0A1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011588-RA">
        <property type="protein sequence ID" value="ASIC011588-PA"/>
        <property type="gene ID" value="ASIC011588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011588"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012379"/>
    <dbReference type="OMA" id="ICYRVMM"/>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="42"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="887"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1532" mass="172616" checksum="E761F2CFEC9C8427" modified="2014-10-29" version="1">MACNELVVTDLCVVIPSKGEKPPHAFCMIHKTLNKGLMGSDVYLCYKKSMNRPKLISYEPEILHRYPTVDHQEFPLTLCPSVPLFCLPMGTTLEIWPHVPGGDGKMKRKPIQPIFSTFVLTVNDGTYKVYGSALTFYEDFDENQLNEQQRELLEWTVDSHKTHSLHVNKSICLLSRWPFGDTFEKWLQFLHRLSICNEKLPVPIERYITHLLDEVPFPSPSILLQLSTLSNNRILLTLPEDSPLPRSGAGFRQLLSNLGPENCLHVLLLVLTEQKLLIHSLRPAILTAVAEAVSSFLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPSDVTCVDLDTNNISLCDSQKHLTTKLLPKRAARILRQSLRNLEELSQNQGSESNNSLDRDLKKRKREQNLEQRIQEALLQFMASILKGYRDYLVPISKAPTIGATDPNALFRMEAFLRSRDKAHHKFFQLLMKTQMFIRFIEERSFVSDGDHNLAFFDECAEKVSAYEDTPTEIKLIEWDAGQNGSERTKFILPPECQPGLPDQTYSYNSFTLNSLLLKQSRRNVLDNTVPQHNSLAPGSPMARRTKHEIKTAQKLARKHQANPELWAKHLLATCYSMYFIVLPSLISENSGREKTVLKTAYDLLSKACKLKVQCDEVCYRIMMQLCGMHNLPVLAVRLHYLMKRSGIQPNALTYGVYNRCVLEAQWPSDSILSSQMRWSRLRNIVIGVAHFKRAGKKFADRRRRSVSQENSLAAAAAAGGDTLESVDGTSRTSLDSGYSQAEHQHTNMTMDFSAFDKLRGRLGVIVRQTTSSTHRQKTADVMSSAGLLISGEGTHHHKMQHKEGKSGYVAVSPAKSSNSCDLSPRMLARTDSFAGDTKFIDKLQRQNATNEEMKARRSLDFQSVGNGSSQEELDSKVSNAKGSPTKISPRTIVTQDDPLGALNHAPNDTIAVSPPRGETTQEGQSHITLRGNSTMYTDQPILFKGQRSATFDDSTQLNKSLQRSETMPMTNTVTSGFASLGSSLKFNFGRYSPARMSMKKDLKSLSTNMLENISSLSPGLTGKKSNEILQGGLSSIKNAASSMAKKLDEIKEAISANSTPVKTGLNETLERDGHGSENDLLQHDDAAILAANGNRSRRVSSDFDLWGRFSESRKSSYNNLVPLGENTTSNVSLYGYPMLPDNIYPMPEEVIKWIISNESKAIIFIYDIILQVLETNVADYVIQMTSCSQCHNCSVLLYDEDIMAGWSAEDSNLNTSCQACGKVTVPFLTVQIISRKEEQHHQSEPSPLHASAARSAPHTQHDVISVPYLNPLVLRKELENILSEEGDLALTRCSFEEEHPIIYWNLVWFMERIDASTHLPNLILPKQENDKIDPLSMVKTVAVQCLWDNPRLHAEAGPAMYMLWRQNQPDSTLLKALLTDQTSINRTIMQQVIASIRCNDLLTPVKRLANERQKLKHRGVDRTHSIYRDMLFLAFVEIGRSEIDLISFHREYAAVFDKLTEKECNTYYRSQDLPPSSMAIFCRAYFKPLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0R2</accession>
    <name>A0A084W0R2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011648</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0R2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011648-RA">
        <property type="protein sequence ID" value="ASIC011648-PA"/>
        <property type="gene ID" value="ASIC011648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011648"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="21428" checksum="49CC1C45EA477680" modified="2014-10-29" version="1">MTARMTAMGFPSFQGWVFGDDDPVPVFPEPKRKDARNEKTFANTRGWPGLSCAHGPVGPFGLRCHGDRLGAALFCMSMSETGMRVPQPSSRTNRVCVSNQRNGSTSRPTGPASRGWPISHPISRKNENSTESPNRCPKRAKREKHGGMKGKGSRFSFTTQCEWVGEGWGYIQKNHRPVTHGCKDEENSGAQFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1J2</accession>
    <name>A0A084W1J2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urb2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011920</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019349">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1J2"/>
    <dbReference type="STRING" id="74873.A0A084W1J2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011920-RA">
        <property type="protein sequence ID" value="ASIC011920-PA"/>
        <property type="gene ID" value="ASIC011920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011920"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007254"/>
    <dbReference type="OMA" id="HNRRTMN"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="701"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="910" mass="104377" checksum="A1DD24702F22F84E" modified="2014-10-29" version="1">MDGCLSDAMMEFMKVLLRKRSFLFWNKFVSLLNEAIEMSDKEHTESSIFQIELAMCWLCYFFAGNTLIENSYLFWEKLSKHIASTDEMMANFARQFLLGEERGEVRLYSAFLKMVYFYGNYRLMVEYYRPDSIETSGDQDIHSYLSEAEWKQIEERMPAEDAPVRNRVLLQKIRQNDLKHNVLDSEMAETRQELIARVVDDPSAENLRWVLLDRSSSGWFLTLLSKQQQIAVVEHLLDRSFCSLEEVKHILLDITPTEELLEVILLTAIKRMVTKCLTQCEKAVSRKLPFEELYEMNESELRPRLKKLLEKSARASTKKPLVDVPNIEEINHLLDVLEEIRIDNFSQEQKAVILAVYLILLVDVRALDGGVIAKCLENQLMRHITHGTVPNVMEYASIETLLSVCGQTPLLVTIFELQAAHLTEEAFNEMTKILDGFSNKTDTRFDVLLLVFNSLQKGGANRLKMVPAEQLSEKLDEFVAVIDAFLLTDAPEKQRNGNIAEFNDELQGCALSIYYKARQKKEITSAMREILLDYITKALTNTSSSACLLLTNCIQYKDFLNLEESILAAIIENRWQAFLKMAQEQTVPKRQDVKLDEKSVDQQHMKTFVTFLTSQLSAAECSKKFAQLDNTLTNHVAGQGYATLKSVLRAFSILARVGFGAKCKEDVSNAFVKPFSTVIARNVMPLCILNEFHNDATLRVEILECFAVVIGNHGIKLPPAVLDHMLEFMSAVNIRKVPVKESEEQSFYKLHRLLSDVMFVLLMARQYFVVHRLPQYMLVFQGLVGAIVCYKDSLPVEQSLNSFEILTISDLLLPLEKIVGFARKRLQKDIRILAPYVLAQILNTIIQSKRATTLQQRVAQKVYNICFELIAVYDGHSSSYLLRTMDESSRLLFTDIVKQYKKFRSYKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Q8</accession>
    <name>A0A084W1Q8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011990</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1Q8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011990-RA">
        <property type="protein sequence ID" value="ASIC011990-PA"/>
        <property type="gene ID" value="ASIC011990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011990"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14899" checksum="C6AC13507707A924" modified="2014-10-29" version="1">MFHVESSKCRPAGGNATPNGKSLRVLAFADAWFLSGGVLAGVAQGDALVRLEMENKSPSRGALFLQEKHMRRGLKENYQHRKQAKQAMEWVSTQYNKVTSSEPPVSCRVRISSERSEAFLVKEGLQMISVQCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4X5</accession>
    <name>A0A084W4X5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Pirin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013194</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020405">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4X5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013194-RA">
        <property type="protein sequence ID" value="ASIC013194-PA"/>
        <property type="gene ID" value="ASIC013194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013194"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022074"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10644" checksum="BF480F80F6F6FF81" modified="2014-10-29" version="1">MLQFDDCMQLITVHTATKWDGRKVAGYRPYDASGNFSRMRKCESRTFAKPHHPGKPVAGRRDAGKNASGIGCVEVRTSRQSAFALTDTFVNRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W505</accession>
    <name>A0A084W505_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00013244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020442">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W505"/>
    <dbReference type="STRING" id="74873.A0A084W505"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013244-RA">
        <property type="protein sequence ID" value="ASIC013244-PA"/>
        <property type="gene ID" value="ASIC013244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013244"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005324"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009172"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="11">
        <location>
            <begin position="64"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="159"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013244-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="591" mass="63017" checksum="D45C7E2D8A982B3A" modified="2014-10-29" version="1">MNPVFRQFSAALKLATQREAIRVLQHRIPVLDGLKLSAISQRRYCCFEMKPKVYVTRNDYARLGLDLLREECDISMWDEAYPVPRDEFLKHVAGKDAIYCSLNDRIDKELLDQAGPNLKVIGTISVGYDHIDVKECKQRGIRVGYTPDVLTDATAELTVALLLATARRMFEANKQVHTGGWKSWSPMWMCGRGVKNSTVGIFGFGRIGQEVAKRLIPFKPARIQFTSRTDKFLTAGDLGVTQVPFDELIETSDFLIIACSYNVETANLFNDAVFSRMKPSAILINTSRGGVVEQHDLIHALKAGKIQAAGLDVTTPEPLPLDSPLLTLPHVVVLPHIGSADIETRIEMSRITACNILAGLKVSVDVVAAVVEVSFRGAGGGGGGFRGGAGGARGGARGGFGGARGGFNRSFGRDDGPKNIIPLGFYDYPCQDELIAKVEVENVPFFNAPIYMEGEKQIGKVDEIFGNPKDFYVSIKLMDNMKPDGFQAKQKLFIDSGKLLPLARFLPGNQTRKPGGRVGKPGGARGGPGGRGGRGRGGGGGGGFRGGRGGFGGGGGGDGGGFRGSRGGGPRGGGGFRGNRGGGGGGGGNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6V7</accession>
    <name>A0A084W6V7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013933</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6V7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013933-RA">
        <property type="protein sequence ID" value="ASIC013933-PA"/>
        <property type="gene ID" value="ASIC013933"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013933"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013933-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10264" checksum="3633A902D99D6E58" modified="2014-10-29" version="1">MITVYHFPVARSQISTMLFYRPGISHTFDPKQKPSARVRASPPASASIRRDPIHAIATRQQIERSESSLKRDQSVDRGRCAIVSSSDVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9P4</accession>
    <name>A0A084W9P4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004804-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9P4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014950-RA">
        <property type="protein sequence ID" value="ASIC014950-PA"/>
        <property type="gene ID" value="ASIC014950"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014950"/>
    <dbReference type="OMA" id="PKHMLPR"/>
    <dbReference type="OrthoDB" id="7763928at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028265">
        <property type="entry name" value="TTDN1/SICKLE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15502">
        <property type="entry name" value="MPLKIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014950-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="23324" checksum="1DB4640C8EF25C1B" modified="2014-10-29" version="1">MSSPTDRNSMGSSSKYDGKSPPLYHSTERFNPLGYSTPQQQQRGHASQQRNYYSAQPKYMLPRTRGFHNRSRSGQNDYHNRSHGATQEIEENDNDMQGNSPTDAGRQNYNRNWRGHQNRNFGGQRYGGQRHQHNFRQKHQARGTSCNIADYFHPSMLEDPWEFFMRKTEREPSDRTEHSIVRDSIPDANAGPEESSNSADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9X5</accession>
    <name>A0A084W9X5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007010-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021960">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021961">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021962">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W9X5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015034-RA">
        <property type="protein sequence ID" value="ASIC015034-PA"/>
        <property type="gene ID" value="ASIC015034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015034"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012062"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021107"/>
    <dbReference type="OMA" id="SWMNATP"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IML1 N-terminal double psi beta-barrel" evidence="4">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1646" mass="186202" checksum="D5B4A70E3D8B854B" modified="2014-10-29" version="1">MIQKLFKLVTHQKTFSTEDLVLNPKEHPDLKLNDIVEIYLPEDEGCRLLLQVTCLNKDFNSRETISVEVNVATTFNLKAYNDVYMRVVDPAEVTLDSVEITFKDQYIGRSEMWRLKMRLTNTCVYLNKKIEYCEGCIRCQVYEMWAQGERVACGVINEDTKVVFRSNTSMVYLFVQMSSEMWDFDIYGDLYFEKAVNGFLADLYKKWQKLGSNHEVTIVLFSRTFYAAKSLEEFPPHMRDCLQIDYRGRFYEDFYRVAIQNERCDDWSTTLVQLRRLFTGYRDVVLKYHERADMPNLQIPPATNSTAAQGNFLEVLNISLNVFEKHYLDRSFDRTGQLSVVITPGVGVFEVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDALTSIDDYSMPHWINLSFYSTNKKIAYSTFVPRIKPPPAIGGSTEPQQPRPAGSARLRLPKKPADKKNEYIHNCLFDYDAYDDQIFQLPAVHGTSSLQRMARTKKTSVPSLDGFGTYARTCEWEPETVCQTRLRRKMSDPDIHHTSNSLLNVSVASHSSSPNTSDILGMPKPNLASAAIIEGRAGAFGSSSGPVVRTGRALINPFDPSHVTIKLTSNRRRWTHIFPKGPQGVLIQQHHYQAVPATTQPSNYYVDLDSSSEYAHTSTCTWGRARHGSTASFDSRLNEDDLKWITENGGGRKKSILHSPAGPHVPGTPSKSLTLLWGATGEQEWTSALTTGVDWKSLTIPACLPITTDYFPDKRSLHNDYVVSDYTLLPEDFNADYAQNRAVYKKPLSTDEVFKELVSQRLAQGFQLIVLPDKSATNPPQAPCCGGQLQPQSYFSNAASSVLRRQPPQEPTKEYLLSIGRIFHRISLSGSAITVTRYRPRHPYPPINVDYRYRFHAPQHDTYEVSGVNFTTEKLENFNWNYMDQYICTRGDTDYPLHENMKYWRYRMYLLPKDDPAMKKILDSTVRHCDIYHEDTPFPSDKQICNDFVRFVEAHLNKIKKIQPAKKTRGCPRQTHLTRRRHSTSILSRPPPNQHGGWVKMYYNGTASNGQNLHHHHHQHPHHHHTPERFLFPSTLTGNSILTRAGSKVLDKSGSAIQTPPPSTGGSGSGGTSSSSATPTTSNAPTPTPTTLPSATTPTPMMVSSIGGKTTVDGIPLSTLNSAAEQGLPEDTDDFAGESCKLKPTATLQEIFDALRHPVHGVGFLGPAQSMPSCTFVSYDAITWLQNRIEGPCQPVDILEEMRRNRLICHASGDFNKPVVPGFCLYYIARQDKESPEYVPPLGDLAAFENEWMEVEIQHPDLTKPIDAHDRGVPAFLRESLDAEGQEDGLVDGLLYKQTHLEIDVSGKSDRTEWGHARYHQRMIPGHAYEIVVQWITASGPIVYDLIYGWCRKAQPCGFQLVTIPADPLAEPFTEKSDPLRGPIFIPLDTECLKQHRSFLFEEFHKESWPRRLLLFQEEIVRRFGFMRCTVETKTGSNQVSLDYQYVHCSGNMFIMVPNPNMGLRSRQRLASGGSNFKKPVHFINRYSASYEAQVAGPGQNGGTTGGSGNAGGGAGHEPSYITRHVTGKGTTKDDCDVMRRTGFLWSWNHMIPNKRWKSLVISQTDDLFQLKMLRDFKEFCANADQRLVNFWESCWELKEKASIERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAW1</accession>
    <name>A0A084WAW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP012276-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAW1"/>
    <dbReference type="STRING" id="74873.A0A084WAW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015597-RA">
        <property type="protein sequence ID" value="ASIC015597-PA"/>
        <property type="gene ID" value="ASIC015597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015597"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017111"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="210" mass="23164" checksum="813EE96005CC53AC" modified="2014-10-29" version="1">MWEQVQPVRIWTKDTKRELIVGKTGTVVSYFPVEKYEASKRLQKVRVEIVDFLTCLASGRHVHGALLKADMFCGKLLNVNDCSKGGEGLVLEHNGNWVAGSLPRTVPEILRASVIQPTANCFLAANGYQSKSSVTVHLGRTDLNSSYAHTQVYKVSKLIPHPDFNRADAVNDIALIQLASSLSLSFENRKSTSSTTKRALLVIVFFTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBJ3</accession>
    <name>A0A084WBJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP010672-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00015555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022359">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBJ3"/>
    <dbReference type="STRING" id="74873.A0A084WBJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015555-RA">
        <property type="protein sequence ID" value="ASIC015555-PA"/>
        <property type="gene ID" value="ASIC015555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015555"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014892"/>
    <dbReference type="OMA" id="PHDATHY"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="175" mass="19000" checksum="A1BB4BC4BFCCBE01" modified="2014-10-29" version="1">MAASLLLRNACRNRSLLQGLGTNGSLPLAAARTIVLKPVKSDERPGESHDDRNARLQRPQSPHLTIYSFQLTSALSITHRFTGLALTGYITALGLGALAMPHDATHYLTMLEGLSAPTLIALKFTMAYPFAYHTVNGVRHLFWDMGKFLTIKEVYTTGYTMLAVSGVLAGLLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBY3</accession>
    <name>A0A084WBY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Secretion protein HlyD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015793</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015793-RA">
        <property type="protein sequence ID" value="ASIC015793-PA"/>
        <property type="gene ID" value="ASIC015793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015793"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8917" checksum="0DA01CFF16F358D0" modified="2014-10-29" version="1">MWKTRTTRPAEAGIESADGGTVFVDAFVDPVTGVGKIRTVGRSSVDSSWAAQFVGEAANRGRHSGSQIWTIRLMAHSHGETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCE1</accession>
    <name>A0A084WCE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015941</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015941-RA">
        <property type="protein sequence ID" value="ASIC015941-PA"/>
        <property type="gene ID" value="ASIC015941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015941"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9641" checksum="11941C573345C774" modified="2014-10-29" version="1">MGIADSTPGFAMEKRPPSGRAIVKFMIQKLIIISKDSTPGTALGFIVIRFTFWGPLPARGQDVREDGLVATNRNDSLEISARTGRHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDF3</accession>
    <name>A0A084WDF3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Activator of HSP90 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016369-RA">
        <property type="protein sequence ID" value="ASIC016369-PA"/>
        <property type="gene ID" value="ASIC016369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016369"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="34250" checksum="1B943EECD11D43B1" modified="2014-10-29" version="1">MPVNLNLSRLVCRQLHTDAVAERLRPHDNKYQKICLRFEERAKITQNLANSARWQIAQQIVHPMAFRDSAGGNRSLKWTWKKIALKDVGSPSPNRRHGSKAHPKKRLFLLAVIACSNVSWEENSSPEAHESERSDCGVRFVCLPHPPSSDGPILVRWRADEESRTVPEIGLDVKHCETIMFQQVAVRFGRAEVSSFEFLKNATIMTAPLDSRSKQPFAQPKTDRSIVTCGCGTSPPGAQNRPVTRAEDCYRVFRAVPPPAAASAERQKKQPCVSEVLELDEDECRNKTDKQERKKKTKHNHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDH6</accession>
    <name>A0A084WDH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Basic endochitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016396</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016396-RA">
        <property type="protein sequence ID" value="ASIC016396-PA"/>
        <property type="gene ID" value="ASIC016396"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016396"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016396-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11813" checksum="6BC413061C463299" modified="2014-10-29" version="1">MYERNNIKFMLCISDCCHEEYTKGVLDFSHFHSFNPALDPAAKKRKLPVKFIQQHNLSRVHMQLLPAQGAPTVIVDEVHVSLSVADCEVKRRTLDVMDRMSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDU5</accession>
    <name>A0A084WDU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Alpha-taxilin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016512-RA">
        <property type="protein sequence ID" value="ASIC016512-PA"/>
        <property type="gene ID" value="ASIC016512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016512"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016512-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10065" checksum="DCA7E2388076C20B" modified="2014-10-29" version="1">MYTTAKCTSFAKRPIHSPTRPNGDPPEGNKKGSIVRKTVLPSHGYLAVDTPGAIAILDRTGFRPATATPRHRSATCYLGAPTSKRTGRTGPVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE60</accession>
    <name>A0A084WE60_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid-binding protein, muscle</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">M-FABP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00016678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds fatty acids in a 1:1 molar ratio.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE60"/>
    <dbReference type="STRING" id="74873.A0A084WE60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016678-RA">
        <property type="protein sequence ID" value="ASIC016678-PA"/>
        <property type="gene ID" value="ASIC016678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016678"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012083"/>
    <dbReference type="OMA" id="VAIRHYE"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19852">
        <property type="entry name" value="FABP_pancrustacea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB48504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14681" checksum="F952AA11F5E9A1FB" modified="2014-10-29" version="1">MAVFEGKKYKMEKSEGFDDYMKALGVGIVLRKLGNSISPTVELVKNGDEYTFNTLSTFKNTTIKFKLGEEFDEETVDGRMVKSVCTLEGNKLIHEQKGEKPTTIVREFTATDLTATMTAGNAKCVRYYKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF33</accession>
    <name>A0A084WF33_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000624-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016986</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023288">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
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        <property type="entry name" value="BUBLIN COILED-COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB48827.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016986-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="13925" checksum="A07BE35C6E5AB87D" modified="2014-10-29" version="1">MPPEPKETKRAPDAPTTDVPSSDTEQATDASDASADEELDELGELDPSSAEFHSINESLDSLSSALDIIEQKNDSLREQLLLLLQSQRETLKSFKEENGRNDDCDAGEQPTGTPGTRQPPAIEPMEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A084WF75_ANOSI</name>
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    </protein>
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    </gene>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="gene ID" value="ASIC017130"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017130"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017130-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12863" checksum="979AAC499BD32D15" modified="2014-10-29" version="1">MRFRCHDPSTPRLFCVPFSSLHAHKPVAHFQVNPRDSDRPRGRMIDFFPSRAKQTRACQGRAGAHAAQTGAYRRLRKMNEKHRISSANEGVCVCVCNKSKSSRLGKKRGEGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">AGAP000906-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00017084</name>
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        <name type="scientific">Anopheles sinensis</name>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ASIC017084"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8123639at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="50" mass="5326" checksum="7549E284F2F1415C" modified="2014-10-29" version="1">MESQDGSAVTTRTTVTTKTVASAGPKPMSPFAKFRQLDKQNSLSSQSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A084WFT7_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00017289</name>
    </gene>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Diptera</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC017289-RA">
        <property type="protein sequence ID" value="ASIC017289-PA"/>
        <property type="gene ID" value="ASIC017289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017289"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7636" checksum="BF9F968D08670FFC" modified="2014-10-29" version="1">MVGAQSESTLRCVFVCTMKPKRTPGDTFGTNCSSTVTGFRTARNEIDIGFAYSVEPGGTMGPMIARGLQTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGJ5</accession>
    <name>A0A084WGJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006611-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017342</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGJ5"/>
    <dbReference type="STRING" id="74873.A0A084WGJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017342-RA">
        <property type="protein sequence ID" value="ASIC017342-PA"/>
        <property type="gene ID" value="ASIC017342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017342"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015849"/>
    <dbReference type="OMA" id="GHMFHHS"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16480">
        <property type="entry name" value="RING-H2_TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="442" mass="49944" checksum="BE89BFFC503E8879" modified="2014-10-29" version="1">MNLMCPICSDLFVPSDEVHITPCGHMFHHTCLLQWLERSKTCPQCRNRCAETRLVKVYFNIAANLDTTEDSASLLQKLDDMTYKIREQEKSLKDFEQKVVDHKGEQKKMRKILLGLEDQLRSKESAILAFKHENDMLKGDRKIKQRLEEELAVLKPQLESYATIKQALKSTVQEVDQMLASDTSRATVVAVAAALKRELQAQEIKRKEQSDRIHRLQNELSDERKKRKAREDTLSACDSEIYRLQQLLKQKNCEKTSNTSANSEDGSFNEEVVPNTPDQHESRRKRPLNDLNVSTPMSEKVRKIMDSTSPYLRIKTSSIGLAPLMRVGNKISANPASSAGISTKPTSSTSQYSIFRNRRPADIISTISSKASSVETNEKNTENTAGDSETAVPEPRFKLTSSTVVARLKTGKLTRHPSTVMQNNTAIDQLNRVPNLELADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGY0</accession>
    <name>A0A084WGY0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008097-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017674</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023768">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGY0"/>
    <dbReference type="STRING" id="74873.A0A084WGY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017674-RA">
        <property type="protein sequence ID" value="ASIC017674-PA"/>
        <property type="gene ID" value="ASIC017674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017674"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015873"/>
    <dbReference type="OMA" id="NQKDYVH"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="131"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017674-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="417" mass="45743" checksum="16973E388809BB77" modified="2014-10-29" version="1">MLPGIGMFGTGEVTHVLVPILRDKGFNIVAIWGRTAKEAEQAALELKIPFHTAKIDDVLLRKDVDLVFITCPPFLHSQISVKALGIGKHVVCDKPMTLMQSDAVKMVRASQYYPTLISIVNHSLRFLPAIAHMKRAIQEGYIGAHGTCLDQTLIDVKVRMGPLFNRKRYDWLCDESMGGGALNLVGSHVIDLVKFLTERKAVRVHGTVRTYAMYASHAHTGIRRVAAPDVCTFQMELEGEGNTPTLVTVNINCHESNNSFQQEVVIYGPAGHLTVRGGDLVGHRLNPDTGAIKEEMLYVDVQDLQFSTSDTTLPRPYVKGLCKLVGALRDAFHPNKESAGWIKEPVQAAATFEDGLYVQAVLDAIRKSSSDRCWTKVSISTESPTNQKANVLVNAAARLASASAIRADPSINHTGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIH6</accession>
    <name>A0A084WIH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018063</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018063-RA">
        <property type="protein sequence ID" value="ASIC018063-PA"/>
        <property type="gene ID" value="ASIC018063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="5245" checksum="9D2F7DDC30C19634" modified="2014-10-29" version="1">MASVSNKLPTNSPAKSSLLLLLLPRPGILRLATVSVAVCELAVPTGMSDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ70</accession>
    <name>A0A084WJ70_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011810-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ70"/>
    <dbReference type="STRING" id="74873.A0A084WJ70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018342-RA">
        <property type="protein sequence ID" value="ASIC018342-PA"/>
        <property type="gene ID" value="ASIC018342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018342"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001892"/>
    <dbReference type="OMA" id="WSQFVCE"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7041" checksum="10070C11622F9B37" modified="2014-10-29" version="1">MGLLLAVGIPVGILLAIFFFMKSSKEMPKNWSQFVCEVRMQICGFQGLLDDFIMRSRNKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ78</accession>
    <name>A0A084WJ78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Two-component sensor response receiver component, histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018351</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018351-RA">
        <property type="protein sequence ID" value="ASIC018351-PA"/>
        <property type="gene ID" value="ASIC018351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018351"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018351-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="10108" checksum="42F605821D2048FF" modified="2014-10-29" version="1">MNYLAPPSSKLANFSRYGVISTKAHRYTFSGALAFGEIKKGYNKCGPSVILREKDARQPFVPADDRFVSFVRLMVRQVSGNRRVACSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJE5</accession>
    <name>A0A084WJE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Stationary phase survival protein SurE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018609</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024018">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018609-RA">
        <property type="protein sequence ID" value="ASIC018609-PA"/>
        <property type="gene ID" value="ASIC018609"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018609"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018609-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="18349" checksum="B1D16EFA84BFDA3A" modified="2014-10-29" version="1">MWHSDFVNRFRTVACPIRAIRQGKNVVDKVPFVTSTFVPAHSTTLKVRQPGLERSYGGDSLRDRRFSEPQHLKSVPCGANALLPDRDPPRAAGHSASIRGHCCSEIVTDSTPGTSTFKQSDTKPHAFTRTTHYYLLLQLFSRGNFPTRPSCLGFFTSEKNLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKW5</accession>
    <name>A0A084WKW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019202</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019202-RA">
        <property type="protein sequence ID" value="ASIC019202-PA"/>
        <property type="gene ID" value="ASIC019202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019202"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="14960" checksum="74D5F6EA1F989703" modified="2014-10-29" version="1">MLLVALVSCRHKVRVASKNHRPPDEPPYCTASASFSFLLNSKSSHGTGVHPLPSIGFERAPSFGVDDKIRWHGKRISNRKPLVFAVLAANKWCRLITLPSDATAARGSYTVKSGLRLLNLHQISSIDEAVCNGIRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLR9</accession>
    <name>A0A084WLR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019422</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019422-RA">
        <property type="protein sequence ID" value="ASIC019422-PA"/>
        <property type="gene ID" value="ASIC019422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019422"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="9184" checksum="ADD63D19E69293CA" modified="2014-10-29" version="1">MENRREMRDPELRHSLRICWQHWPAVRFVYIARSSTSGAVTHSSPRLLVPIETIRLSLKGKVICGSMEFVWDEDKVCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLU7</accession>
    <name>A0A084WLU7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019453</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01024291">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WLU7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019453-RA">
        <property type="protein sequence ID" value="ASIC019453-PA"/>
        <property type="gene ID" value="ASIC019453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013419"/>
    <dbReference type="OMA" id="NEDGYPV"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000726">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="77"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1106"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="880"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151079" checksum="00873D846DBDADAC" modified="2014-10-29" version="1">MGKRNAAAAIVDADRLQQFETPPKRMKHAAPSTTPPSTVPPPPTSAASPANDSACEFTLSKEFVDGTKLMDLTLKQWRIGKPIGKGSFGEIFLASDDIDTPVTSENAKYVVKIEPHSNGPLFVEIHCLLNTAKRSDTCHIPPGMPEYIASGSHMFKNERYRFLILKRYERDLHSLIKNKRVNPKSIPVVACQILDVLEHLHDQGYVHSDIKAENLMIGKVESGEVAPGRTSHANGRNGATVGQQRSPSNGTTLPEGGAKAPAGGRGGKKAHEEASFGGGGGHLVENGLYQHQEQEMGGGRSRNLRPLKTVTYRDLSDEDGGGAKKPSTTGHRKRGRKKNDDASFSCSISPRRSGYEELRAATLEAHRNELKQHQQQVIEQKKPAGVPEDRIHLIDFGLASKFMDSTGQHRPFCMDQRRAHDGTLEFTSRDAHMGAHARRSDLECLGYNLVYWSRGFLPWKDEKLLNQPEQVHRMKEYFMTDVREMLRLIYGDDCPAYLGDFLAYVGQLTYDERPDYQHCRALFLKELKRLGCPVGGRNHPLRLDVEAIERHSEPLTAQDEAEITNKINHVKSLMKLGALFPYRESTLHSKATSPKNLRSKRRHINGRNALAGGANGSEASAGVASSQGAAGDGGLGALGPSNAVGARKREKKISCEEIFATDADQIARERVEKEYERAEQMEETVIRYTGRPTYAIQELERKIRYSGHSGGGGGFGGGCGGLDYTESEDYIKGYTKPMMDILRKRQSQLFREIEASNAAAKRSKGAEPVVVQVEETADDGEEEPMEQEEAAAAEEDEAEKYDDEAEDDEDDDEEVEKKLRRQNYYHDTDYEVQPEEEEEEEDELSTVEEEEEEEEEEEEEVVVSRKGRPKGGGSKKQVEDTDSDFFNDEEQEVEEQEEGEEDEDQQDSDFNDQETSSSTATTSESEVVIPSSRRGRHSRKKRRADEVVVHHDDDEEDDGDNARHNGHVIGAPAVTVRHQHNHNNNNCTNSKAYYGDVDDSSHDAPPVLLNGGGGLSSESKYRLVKRRKSGLRERIRPTDRGNDYNQQRKQKAARRDKRRTVSEAASSVAANSTHDQPVPPVQQPRKRGRPRKVVVTPVVAEEVSEEAIFPQTTSNGSSKNGRRRREEECSEKSTSVREAAAGDGSDTAHWSRTNSHGGGSASTTTATSSRSSSVSASNGSGSGPERLPTLPEDDDFLDEDDDDTRDIDYSPVCTRRKRKALTGTTSGGNGISAARKTTAPVRKRNDSKGGNSRGTGPAPSSSSSVADSGVAINQQLPGRVIAQPIAPSVRRPPVEPPPQQPPAPVVVAIQPNRGRRLPAHHQNYYHPLEEPVARLHHHHHQLHHHHQHLQHHHPPTMLVRTYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMU5</accession>
    <name>A0A084WMU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIL domain polypeptide</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMU5"/>
    <dbReference type="STRING" id="74873.A0A084WMU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019603-RA">
        <property type="protein sequence ID" value="ASIC019603-PA"/>
        <property type="gene ID" value="ASIC019603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019603"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006361"/>
    <dbReference type="OMA" id="RNKSNRC"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760029" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="9934" checksum="5A647FA33CEEC6A3" modified="2014-10-29" version="1">MANTKLVCSVVIVLVLTILVSVTHAQDAATEVCADPNETFDDCGPSCGDRTCANRSRNDAKCLRSCASGCFCKGGFVRNKSNRCIASYMCASMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNF2</accession>
    <name>A0A084WNF2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNF2"/>
    <dbReference type="STRING" id="74873.A0A084WNF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019839-RA">
        <property type="protein sequence ID" value="ASIC019839-PA"/>
        <property type="gene ID" value="ASIC019839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019839"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011752"/>
    <dbReference type="OMA" id="IEAIWPC"/>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019839-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="427" mass="48973" checksum="E2AC06595A6C08E1" modified="2014-10-29" version="1">MPECKVWRNPLNLFRGAEYQRFYWATQKEPLTFYDMNLSAQDHQTFFTCEGDAGKAEYEIMQTAWRERNPVVRIKAAKNALEINPDCAPAYILLAEEEATTIVEAEKILRTALKVAEGNYKKSQTFQHQGAIAEGIHRRDTNVLIYIKRRLAMCARKLGKLKEAVKMFRDLTKEIPPIMNVLNIHENLLEALLEMQAYADCQAVLAKYDDISLPKSATICYTAALLKARVVAEKFSPDIASKRGLSPAEMSAVEAIHRAVEFNPHVPKYLLEMKQLILPPEHILKRGDSEALAYAFFHLNHWKNVEGALNLLHCTWEGTFRMLPYPLERGHLFYPYPTCTECADRELLPSFHEVSVYPKKELPFFILFTAGLCSITALLALLTHQYPESMGIFASTTLNWFSLPFHFVKERIESVWPCNLLQQLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ76</accession>
    <name>A0A084WQ76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525379">
        <property type="protein sequence ID" value="KFB52370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020581-RA">
        <property type="protein sequence ID" value="ASIC020581-PA"/>
        <property type="gene ID" value="ASIC020581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020581"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020581-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7328" checksum="63E4DDB40E13F6D9" modified="2014-10-29" version="1">MPDFQELQANAESPQVHAHHRTRPWSSSTACVSVRIRPAKRKCSSAFREPPTLGRHCGSKTFYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQB5</accession>
    <name>A0A084WQB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010943-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020638</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025465">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025466">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025467">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525389">
        <property type="protein sequence ID" value="KFB52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQB5"/>
    <dbReference type="STRING" id="74873.A0A084WQB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020638-RA">
        <property type="protein sequence ID" value="ASIC020638-PA"/>
        <property type="gene ID" value="ASIC020638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020638"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022766"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23529">
        <property type="entry name" value="GH19118P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23529:SF2">
        <property type="entry name" value="GH19118P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9783" checksum="20D4010E61512A84" modified="2014-10-29" version="1">MGCTEWMEMNQKNKPQSNALAAGILSLLATSMFLAGTLYNTGYKNQEWALDQSDSAVVTALLMFHVTAIISFAVTCFLIERYPKKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQM7</accession>
    <name>A0A084WQM7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020769</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQM7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020769-RA">
        <property type="protein sequence ID" value="ASIC020769-PA"/>
        <property type="gene ID" value="ASIC020769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020769"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020769-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13513" checksum="A9D5AE03BA16AACE" modified="2014-10-29" version="1">MAVDPSLDPSPQRPLASNTFTKTHQNLLKRSHRNANQRFTWDQKYDIQARSNSNPDRPAPDGHQSPDAFGSAARTHPHGSHTFSEAELSKKHFWTWYSTLGSHFARVCLFGDLPKKGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRL5</accession>
    <name>A0A084WRL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP006104-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021189</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRL5"/>
    <dbReference type="STRING" id="74873.A0A084WRL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021189-RA">
        <property type="protein sequence ID" value="ASIC021189-PA"/>
        <property type="gene ID" value="ASIC021189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021189"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016242"/>
    <dbReference type="OMA" id="ATFVTFE"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000051">
        <property type="entry name" value="Mitochondrial carnitine/acylcarnitine carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="110"/>
            <end position="128"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
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        <location>
            <begin position="105"/>
            <end position="194"/>
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        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="301" mass="32310" checksum="672726975743FD98" modified="2014-10-29" version="1">MSENKSPIKYFLSGGFGGVCTVLAGHPLDTIKVRLQTMPLPAAGQAPLYAGTLDCAKKTIAREGFRGLYKGMSAPITGVAPIFAVSFFGFGVGKRLQQKTPDEELNYTQLFAAGAFSGIFTTTVMAPGERIKCLLQIQQGGNSPQKYNGMVDCAKQLYAEGGMRSIYKGAFATLLRDVPASGMYFLTYEYIQRALAPKEGEKKDASIGLLGTIFAGGMAGIANWAIGMPADVLKSRLQTAPEGTYPNGIRDVFRELMRREGPLALYKGVTPVMLRAFPANAACFIGVEIFMKFLNVVAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRN5</accession>
    <name>A0A084WRN5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006980-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021154-RA">
        <property type="protein sequence ID" value="ASIC021154-PA"/>
        <property type="gene ID" value="ASIC021154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021154"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023176"/>
    <dbReference type="OMA" id="AMPGENT"/>
    <dbReference type="OrthoDB" id="7743328at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785142" evidence="2">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="208" mass="24048" checksum="B6F8A7EC39752C1E" modified="2014-10-29" version="1">MLKVLCMLAVIVVVAVGMPQNSVDWPAPRPIPMGRLVKREIPTPSVPETEQKQVTSNEPTEAVEGQDDMDKAETFGFGYHRYYTYPRYYYPSYYYGYYPRYYYGYYCAMPGENTPVLEGNNDAPQLTPVSEDAPTVSGTTDTPEDMDKAETFGFGYRKIIHVYPHYYPRYYYVTQIGTYGPWAESLVEELVLIVWNAGEGWYDWEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU90</accession>
    <name>A0A084WU90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009706-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00022019</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU90"/>
    <dbReference type="STRING" id="74873.A0A084WU90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022019-RA">
        <property type="protein sequence ID" value="ASIC022019-PA"/>
        <property type="gene ID" value="ASIC022019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022019"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021097"/>
    <dbReference type="OMA" id="QQKEYGY"/>
    <dbReference type="OrthoDB" id="6765072at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="42988" checksum="516BEC8CEE71CAAF" modified="2014-10-29" version="1">MATVESYHNLMQMLSISSKIVGVEIWTAPGRYRPASYYLSFHVIVYFLSSIYTLAKYSNDHQHQMKILITLGSAIQLYVKFFVAIKRGFEFKEFTELVEQVLLAPFQCGSPREVAVLQRTGRVMWIIFRLIATSFLSTAFVFGLYPLFAYYANGTVMPLFLYELPYYDWSTTGGYVANMLFQVNLYVLGIVGAIYSDVIFILCALYTMAHADIFMLHLHELQEILNDSAFMENDNSAMNHKWKQCMYDHQQSVKFFNSVDDLFNIIILVHVGMGLFSICDGMLLVALTDWYAAYFFLLVLFFQLTLYFLIGHYVELKVDEMYKTINSVPWYKLPVSNQKEFVFLLCRQQHPLILMVYGFAPLNFATYMSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUD2</accession>
    <name>A0A084WUD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP010694-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00022301</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUD2"/>
    <dbReference type="STRING" id="74873.A0A084WUD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022301-RA">
        <property type="protein sequence ID" value="ASIC022301-PA"/>
        <property type="gene ID" value="ASIC022301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022301"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014756"/>
    <dbReference type="OMA" id="KYSARMH"/>
    <dbReference type="OrthoDB" id="8175758at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022824">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000032">
        <property type="entry name" value="gamma-aminobutyric acid receptor subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000032">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="36"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="249"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB53826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="456" mass="52010" checksum="F4232AA68AA300EA" modified="2014-10-29" version="1">MTPNVRFPAGTTGTQSILKEVLAAKNYTLKPRVVLPEDYVKEVRPPSEKGSPVVVEFSIFVVDINSINVEDMDFRVDMFVHQKWVESRLDLHDDIFEDGDDHVILPPEFFDNLWQPDPYFLNSKISEIATLTHKFSSVTLYKNSTVRYACMMHAIIACQMEFQLYPMDIQICPIYIESFSYHNQKIRLKWADNGVTINPELKLLQYNLGRPLQLEETDGYMPEKYGNFSRLAVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGMRADIPPVAYVKALDLWMAGCMLFVFSALGEFVVVKVLDVQYQYQVNKVPKVLPMRISAMEKGQSIGTVANWEGGTVSVRPRKPTQTPTTPGQVSLQGNGGPQPPLPPAKQPTRRQSILSVAWTDTDTGIEKIMWREIDKMSRVVFPGLFLVFVVLYWPILIFKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUX6</accession>
    <name>A0A084WUX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Triosephosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022278</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027175">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB54020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022278-RA">
        <property type="protein sequence ID" value="ASIC022278-PA"/>
        <property type="gene ID" value="ASIC022278"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022278"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB54020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022278-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10683" checksum="012B56F5ECD943A7" modified="2014-10-29" version="1">MGRYALYNHTPPYPPIPGRLVRRKCRISSDQFYVFFVSTYGFSKLIISFRSVQAIGAGPGLLHFRANNLCHYSRAGTAKMSTPNQLFSKVPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUY9</accession>
    <name>A0A084WUY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP006406-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000925</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL641983">
        <property type="protein sequence ID" value="KFB54033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000925-RA">
        <property type="protein sequence ID" value="ASIC000925-PA"/>
        <property type="gene ID" value="ASIC000925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000925"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001445"/>
    <dbReference type="OrthoDB" id="6755972at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB54033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="245" mass="28252" checksum="B68DF4EC7560BA02" modified="2014-10-29" version="1">MATTASKICIRPSRYDRSDPTNRKETCKMVDDFERNFITLLKRNPIDRRVDQSLSHRLAKRTNRCIEAVKRKDLPPFGWYRENTQAGHDAEDGVSQPGHVAMQMQVAIEPKSKPRPLPPRVEGWMGNFLRKPTRKRILWRSKLYEYEPCNREAPERAEQQVDAGVDDFVRWLNGLGAERSTLTKDIVKQLFSSESADETSRALNIAPKEIRAVPESVAAEWSLPQMGLENRIAEVHSRNRKWSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA07</accession>
    <name>A0A084VA07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Recombination protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000220</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01001014">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523931">
        <property type="protein sequence ID" value="KFB34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000220-RA">
        <property type="protein sequence ID" value="ASIC000220-PA"/>
        <property type="gene ID" value="ASIC000220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000220"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9446" checksum="3F4B6AA75FF56235" modified="2014-10-29" version="1">MHRTGTDRETVNHSALRVSSGLARAGVNRRKPGAKPGPPSVELSEPGRTTEPNRTSCKSATAQHRTETKRLQHRNPSHLHHLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAC9</accession>
    <name>A0A084VAC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000608</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01003060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524109">
        <property type="protein sequence ID" value="KFB34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000608-RA">
        <property type="protein sequence ID" value="ASIC000608-PA"/>
        <property type="gene ID" value="ASIC000608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000608"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="9155" checksum="EF5AEAF1678FEF9D" modified="2014-10-29" version="1">MLWRTGLSSLMEVYRNRLPRKPHGQQKQHPREGIDIVPDRFRHASWVILLCACYESPQHSRHPRSRLAAIDTALRTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAH1</accession>
    <name>A0A084VAH1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00000723</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01003736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01003737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524159">
        <property type="protein sequence ID" value="KFB34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VAH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000723-RA">
        <property type="protein sequence ID" value="ASIC000723-PA"/>
        <property type="gene ID" value="ASIC000723"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000723"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020778"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000723-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="772" mass="84397" checksum="294802E95F4E10A7" modified="2014-10-29" version="1">MIPTPTEHSLRVMVVNRIEQIVLNLWPSARVEMFGSFRTGLYLPTSDIDLVVIGQWEKLPLRTLEMELINQGIAETNSVRVLDKASVPIVKLTDRQTQVKVDISFNMESGVQSAKLIKGYKRDYPVLEKLVLVLKQFLLQRDLNEVFTXXXXXXXSSSSSFTVARISVKTGRYIPKEELQREMIDGHRPSLLCIEDPLTPGNDIGRSSYGALHVKQAFEYAYIVLMQAVLPIDKNLNDCNRQSILGRIIRVTDEVIEYRKWIRDTFEGRLIRQPATNTSLPLSTTVLVSDQHYLPILQQQQQNTRHLPQQQQQQQQQQQPQQQVLHHQQQHAPYARVYYTRRPSTSSVELSEESMDSDGGGDGCNNCRVVRDTSPTSGLTQSPPGELYDVQGGTQNVTGPTIMMLPAHLASNASHSHDMLIEENNMLNMAHHQQQQQQHQQQHPPQQQQQQQQLSDPNAIGDSQVINYNNVSNKRAAPRNTMMKHLRKMHVPNVPMNNRRIIVPSPNQQSYQHHQPTEGGKGGSGGGGPYNRSSAERLLTKSAHGIGLTVNSSQHNSNTNNNIHGNSGTQHPSTTAHHHHHPFHSSNNGLVRHNSSKHRHRSAIHGVAVASSYQSTTGGCAGGGDGDGNVLRSFNNNSIHSSSDHRNGSADMVLQDENSLLYDPTTFATKLLPAGFFATGKQICHIISRGGSSGSGSSSNGGASSGKKSSHSSSKRKKTNSPGDKNRLMASGGVAGGGGGGGIGSTGPTGIDFGLSSGGSVVTVSATALDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCF0</accession>
    <name>A0A084VCF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007551-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002501</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524597">
        <property type="protein sequence ID" value="KFB35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCF0"/>
    <dbReference type="STRING" id="74873.A0A084VCF0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002501-RA">
        <property type="protein sequence ID" value="ASIC002501-PA"/>
        <property type="gene ID" value="ASIC002501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002501"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019296"/>
    <dbReference type="OMA" id="YRLCESP"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="350" mass="41247" checksum="B22036AC31A027D3" modified="2014-10-29" version="1">MDQFIRGTCEDMCPKSEIDLRIRERLVHFFETEAPGVPDRHRMVKEFSRSAADRRQPKPWEIRTPRALMESLHYLLTIVLTDTRRPFHQRYEFIFDRMRAIRQEVVIQNLPATEALPLLKPIVRFLCLSAYRLCESPISEFDPKICSQHLQECLKKVLRCQEELSKLDKSFTWERFEMERLYLAFNLGSQEATSWAINRHGTVKPELMPHIAAQIDCLRGNFFGAIQRMFRFTPLEAAVASLQLPTFRRRILQQFSIAYQSRVQTVPLEWLETVLHYDVHERSFLPDDCRHYNIQLVPIDKGNRAWAVKFERTQFDAQQPVIPPRKSRFIDDALERGGSISDVLLCDFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCY6</accession>
    <name>A0A084VCY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011011">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011012">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524633">
        <property type="protein sequence ID" value="KFB35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002761-RA">
        <property type="protein sequence ID" value="ASIC002761-PA"/>
        <property type="gene ID" value="ASIC002761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002761"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12389" checksum="FBB68D5B87411AA8" modified="2014-10-29" version="1">MSTYLKNKLLRRQSGGMDFPGRQHRSRSLDVEALQRSGVQALMIKAAAQHQQQLAAQCLDQFENAFLCPLTPKLLPNINNSWPPNVSTTLSFVLFDLDQFENAFLCPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDB5</accession>
    <name>A0A084VDB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009579-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011220">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524654">
        <property type="protein sequence ID" value="KFB35959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDB5"/>
    <dbReference type="STRING" id="74873.A0A084VDB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002930-RA">
        <property type="protein sequence ID" value="ASIC002930-PA"/>
        <property type="gene ID" value="ASIC002930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002930"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005807"/>
    <dbReference type="OMA" id="IRRCNES"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000095">
        <property type="entry name" value="Dihydropyridine-sensitive l-type calcium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000057">
        <property type="entry name" value="Voltage-dependent calcium channel subunit alpha-2/delta-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF31">
        <property type="entry name" value="CA[2+] CHANNEL MUSCLE-SPECIFIC ALPHA2_DELTA SUBUNIT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-2/delta subunit conserved region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="897" mass="104337" checksum="67A5227E4448AB17" modified="2014-10-29" version="1">MLVQATPENMRFFNEYVRELQPEGYANVKKAFVAAFELLQKYREIRRCNESVSGCNQAIMLITDGVPSNITEVFERYNWFENGTKIPVRVFTYLLGREVTKVREIQWMACLNRGYYSHIQSLDEVQEEVLKYVTVIATPLVLQGVEHPPTWTHAFTDTAENLLTEADDDEPPRLMIAVGAPAFDRKANHYNETRTARLLGVAGTDIPVEDLDELTLPYKLGVNGYSFIVSNNGYVLMHPDLRPVSNGRLKENYNSIDLTEIEQIYDENITRQVEDMTGREMSPFILELRQHLVDSKFGNMTKLPVRFHYDKMRRVSLEYQDYYYAPLENTPFSLGLVLPHDYGSTWIKVGDEIKRNQHMGLNISDFFVGDNWKVHPEWVYCKYHYLEGHEFKTPEDELRHFLNRLYEPTWKWSQQYEPEPEDFKDSDAPNCGRKTLDDDAYYCNKELVQLLIFDAKVTNNSYRNWEFENENERKIIEMYNATLRFVATMSGLTRWQFIFGEVEVDTDSEFGDYHKKAIDETWYRSAILQHKIDPKSFVYSVPHESDPPEDGELKVTASMAIFPRDGGLEAPGCVTGFQFTHSLMYERFMEITSKTTCDGCIETCASETRDCYVIDNNGYVVLSETSNHTGRFFGEIEGAIMQSMVDKEIFNMITVFDLQGLCEYERVVENDAMALMHPMKLIMLGLKWLIAEVAMALTRFDFWVHGIPSADYFDPHEYDDYDETQRLKPKKIHVDEEEEYFNRPKEIKKEIVYEACDKKSNLYVMQQDKFIKGDGFFYEPPPALLDNLQYPPYFAKRIPRSNLLMIIVENEYQVEKVVLSAAPEVIYHNDTEGLPCVKTKLNFLPRRRLEECYTDHPDEEVVAQCGSGSRLTIQLTVVISTIVSLLLYRCAQTVVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDQ6</accession>
    <name>A0A084VDQ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00003135</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDQ6"/>
    <dbReference type="STRING" id="74873.A0A084VDQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003135-RA">
        <property type="protein sequence ID" value="ASIC003135-PA"/>
        <property type="gene ID" value="ASIC003135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003135"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016352"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021608"/>
    <dbReference type="OMA" id="NNWISPI"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="101967" checksum="EF213D2E97FF32F7" modified="2014-10-29" version="1">MEPINAVLAGLIFIVSVVYLFVRSKHNYWKDHGFPHVPNPHFLYGHAKGQGQTRHGADVHQELYWEFKRRGEAFGGFSQFVIPSVIVIDPELIKTILVKDFNVFTDHGVFVNAKDDPLSAHLFALEGQPWRELRQKLTPTFTSGRMKQMFGMIWDVARELDQYMEEIHRQPEVEMKDILGRFTTDVIGTCAFGIECNTLKAPDSEFRKYGNKAFELTPLMMMKAFLASAYPGLIRMLHMKITNSDVEKFFMDIVQETVNYRECNNIKRNDFMNLLLQIKNKGKVDDTDSNASVGKGEVGLTQKELTAQAFVFFIAGFETSSMTQSFCLYELAKNPDVQERLRQEINRAIEANGGEMTYDTVMNIPYLDQVINETLRMYPPVESLSRVPSVDYTVPGTKHVIPKRTLVQIPVYAIQRDPDHYPEPDRFNPDRFLPDEVKKRHQYVFLPFGEGPRICIGLRFGVMQTKVGLITLLRKFRFSPSARTPERVKFDPNMLTISPSTGNYLKARKWPIGGALLHLTPCVIVTDAKLIEHVLSDEFTKRELDVRGMRAFRCCWDAFEDERFEDLLRVATEESRSLANVLSAKDETIEDVKAAIELLVVRTLARSLFGKKWNEKHPLPLSSLVESSQCNGFWGIAMSSLPSIQRLKAFLHLDDPTILEELVHSLESTCTENNYFLEYLKRMESKASSTDRLAFSHTKVLLRELVQNVFFFASSTIVTCLYELAQHPELQGSLHLLLKRSGDAMVDELDKVIGETLRKYPPVDEISFISAANNRLPGCELVVPRNTKVIVPIYALHRDAEHYPDPTRFDPTRPMLRSLDRSFPSCLYQPLGNKPLPVGTNFAMMLVRVGLTSIIARCRLRMAPKSPTHLEMSPTQPIPYPRGKIMLRIEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE17</accession>
    <name>A0A084VE17_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00003318</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524764">
        <property type="protein sequence ID" value="KFB36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE17"/>
    <dbReference type="STRING" id="74873.A0A084VE17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003318-RA">
        <property type="protein sequence ID" value="ASIC003318-PA"/>
        <property type="gene ID" value="ASIC003318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003318"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020237"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="608" mass="67623" checksum="6BF4B4EDFCABB3F0" modified="2014-10-29" version="1">MSETISCTPEVATFEVPQLQFNEDGWGPCELPEAFKDIPYQPFSKSDRLGKISDWTGTAQTDKKFSNKYASQFGGGSQYAYFHEEDETTFHLVDNARIQKPPINGDVSGATCETIGKLCGTSVHCWKEMLIVSVCCSSGRGRGARGGVQVGGMTTLSKAASKLRDQRRGTTRKWGMRGPPPKIRDASVTVRPDWVTIEEMDFPRLSKLSLPNVKEGEDIMTCGTLEYYDKTYDRVNVKNERPLQSVDRIFHTVTTTDDPIIRQLSKAHGNVYATDAILATIMCCTRSNYSWDIVIEKIGDKLFMDKRDNTEFDLLTVNETASEPPQEDGNSLNSPRNLAIEATFINHNFSQQVLKSGEKEPKFKFGHPNPFIGDDEDGEVASVAYRYRKWDLNNGITLVARCEHDGVLKVPQGDTQFLTIKALNEWDSKIANAVEWRHKLDTQRGAILANELRNNSCKLAKWTIQALLAGSDQLKFGYVSRAHVRDSSKHVILGTQQFKPQEFANQINLSMDNAWGILRCIIDICMKQKDGKYLIMKDPNKPMVRLYDIPDNTFESDGEEEEGDDGEPFQPMYGYSATGGGASAAAPATASTDGDAASSATKSEKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEI4</accession>
    <name>A0A084VEI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ORF-A short, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003540</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="15"/>
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        </location>
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        </location>
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        <location>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="377" mass="40857" checksum="964F540C9A4B3035" modified="2014-10-29" version="1">MCKGFHSLQRDGQMVDVTIAAGGKIFKAHKLVLSVCSPYFQKIFLEHPSQHPILFMTDVNSHHMAGLLDFMYSGQVGEGRSNPDSRDPATDQCVSLTNVLVNVKYEDLPNFLKVAEALQVKGLHGEELMKAKHAAAAVVLNEDYLNNNNSAAANNNNNNGNLSSNGGANGPLSPYASKKMLDSQKYQKYYSKRKLVQQYEQEMRAEKRKLGIEDVIQAAAAANALNLRLNNGGSPIGSPSAAAAAAAAAAALNPPGTPTNGGTSTDDEQQHQQHQQQQQQPVLLQNIKSEPHYDDEDEGMEVDQDNNNTLSAANANNNNNNNEDDYYGQHDQGVITTGNGKTIKHSILEPNIVLKQSDECLTTSNQTGSLNLCKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003850-RA">
        <property type="protein sequence ID" value="ASIC003850-PA"/>
        <property type="gene ID" value="ASIC003850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003850"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003850-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13724" checksum="61B7384D72FEFAB3" modified="2014-10-29" version="1">MSKPNVLFASAGRKQNLPPKAARGIGQADGKVYRFKPRCLEIDFNFTLCSTARFESSWKKIEAMSETTAHNPCPTQSRRKTFVRKTAVRSTYLHWPGEIAAAGERSCCLGFCPRTHGSSNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFL5</accession>
    <name>A0A084VFL5_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Dgri\GH19443-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00003916</name>
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    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="ASIC003916"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003916-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="15468" checksum="5F1E902CDE960E67" modified="2014-10-29" version="1">MGLPDIGNISLCGNALPPDCSSNYDEGNSGKRTKNYPVAGDLVIRFTCLEPQPLSHTCLIDEGFGEQPNGCRTEQRLRDDYRPNRRSVYFLSYHYTYRKRACECDGLHTIHGVRPEEVDGMVRYVFNRSLPLSIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG56</accession>
    <name>A0A084VG56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP002041-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00004124</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC004124-PA"/>
        <property type="gene ID" value="ASIC004124"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC004124"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019485"/>
    <dbReference type="OMA" id="QQTDFML"/>
    <dbReference type="OrthoDB" id="5977959at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 541"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="Trans_reg/Corepressor"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
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    <dbReference type="SMART" id="SM01189">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="132"/>
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    <feature type="domain" description="C2H2-type" evidence="11">
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            <begin position="133"/>
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        <location>
            <begin position="446"/>
            <end position="473"/>
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            <begin position="1314"/>
            <end position="1402"/>
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            <begin position="1405"/>
            <end position="1457"/>
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            <begin position="1546"/>
            <end position="1575"/>
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            <begin position="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1610" mass="168275" checksum="53D48C046A86C97F" modified="2014-10-29" version="1">MVTVKSSAGGSPSAASSPTASTTSLVLAAVGRSETISPAMASGNSSAASSPSAASSPGGLAKKPRPKTVSPTRHGPQQCQVCSKVFGNASALAKHKLTHSDERKYVCNMCSKAFKRQDHLNGHMLTHRNKKPYECKADGCGKSYCDARSLRRHTENHHTALGLAGGASGTASPGPGGGSNAGPPGGLSLSPATASGRINSDLTLPAHFLIHTHARSWLIYPFRSLSSSVFPSGHASTPSLPPIPRNNTPKPGTNSDKNSPAPGSGNEGLTRQQLDLISQIMQQTKQANAAAAAAAAASSSSSNASTNNAQNKLSATATSSTTTTTSLVSAVPSVSSLAATSTVASTSPTSTLVSTTTTSSSSSSTNTKVPNAGSAGSADPNGPLTASSGSVSSTTAPGAVGAVSTVNSATATTTSTTTTTTSNSNSTNPQQPAASSNNNKLEQKPVECNLCHRKFKNIPALNGHMRLHGGYFKKDSEAKKCDKKENTGPPLQTASVGVRALIEEKIINKRSKDLKNLLLKGSFVVPAPPLTARRLIEASEAFLSPKPGTVAIVSTQNGTTQIINTGTLHTKATILTANNASSSGAPPSITINGLTTTTAAGTIMATGIPPGTELKDATLIELLKRGTKVAVKRAATPILNQPQQQQQSVGSSITTTTSTSSGAGNLISSGSRSVVLPGTTLSTPTKLTTTPSNGTSLMSSTADSGPLSLTISQATGGSAGGDVFTLAYSTDTGGGTTFFSDNDVYSVSDTAMLLQAVDSIQLLQDSNSAEPLDEIALSDYSSITDQGFTPSRQIQAVLDSPLPESLAEFGALNSKDFVLYGSTQAPSVSNGPSGNSTGTGNNLLESPSGAHLSPLPSPLAYPTPPASHEAVAQASPFLDDSRHFTDAGSFFDDKRGQNFLDDGFFKSEPKGDEHGTGTGAGKLTDSEKILALKNELLDHEHHDLFRSNKNLLDEHCSELFKSEDSFFAESKPSPVDGTSKMNLDFLDDAQVFIEETRNAASPLSNAFFSATMHAASAEEVKEALEVVLPNDDDIGVSEGDIDLYYLNGLSSLQSQMMPNSDDPLLSSSPKDFAHRQHQKFLFEQSQQQALQQHQQIQQQNLRQQQQQQQQQQNHSSTHHHPLQQQLTAANNCMPPSAKKSKPCVGDSTTILGGDSSKVPLTVQTEPMSKGTDSVFLSPSSLSSHSSSSSSSSSSSMATSAASPKLQHALLGGGGGSIVWPRKRSQTSTGGNGLSHPMGQRKPTIYLSKLRRSTTTSLPAVHYTPSPMLNPERTGSTGLYANVAHSRASGLDTDLDSTMDSTNDIFSEPPLPIRPRINLGPDYQATLPDCTRSSVYSGLQGYAGTQLWDPVVAHNERQVQRFIELARSSAAPLGCHSEENALQALLEANGEIHVAILSMLQAPPASIHRRWTAGEIEQFIQGLESYGKDFHRIARELLPAKSTADCVQMYYFWKKLCIDYKHSHGAAHRLVDGLVASKFAGSSSPSPPPPVPAPPPVEDLLMDHLDYTSTTTGTAKGHHSSQPTAATNGSTQPSGNAHTAPSDVRPHVCEVPDCSASFSSKAALHGHIRIHCIGRSHSAIQNGNFLSAAGNPINPNLIPTKDDYPCKVCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGI7</accession>
    <name>A0A084VGI7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00004282</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524828">
        <property type="protein sequence ID" value="KFB37081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VGI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004282-RA">
        <property type="protein sequence ID" value="ASIC004282-PA"/>
        <property type="gene ID" value="ASIC004282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004282"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010663"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019993"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020693"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021574"/>
    <dbReference type="OMA" id="PPRHPCQ"/>
    <dbReference type="OrthoDB" id="7783995at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
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        <property type="entry name" value="Dumpy, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000526">
        <property type="entry name" value="Dumpy, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000686">
        <property type="entry name" value="Dumpy, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
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        <property type="entry name" value="Plasmodium vivax P25 domain"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KFB37276.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004497-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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</entry>
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    <accession>A0A084VH38</accession>
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    <reference evidence="1 3" key="1">
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Shi L."/>
                <person name="Hou Q."/>
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                <person name="Xiong C."/>
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                <person name="Yu X."/>
                <person name="Zou P."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
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            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="12743" checksum="93E2A27DE639D46C" modified="2014-10-29" version="1">MKFDSGANNSEMWSLIEVSTISRGLLCAACAKRTNGRFTNCPAKLLRAGERTPILISRQRNVWDHGQICAVNLPQCFIMSEMARSAYGAAPLLNASRKGATNMAKVFFCLMTPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI02</accession>
    <name>A0A084VI02_ANOSI</name>
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        <submittedName>
            <fullName evidence="1">AGAP012173-PA-like protein</fullName>
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        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00004837</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI02"/>
    <dbReference type="STRING" id="74873.A0A084VI02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004837-RA">
        <property type="protein sequence ID" value="ASIC004837-PA"/>
        <property type="gene ID" value="ASIC004837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004837"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008769"/>
    <dbReference type="OrthoDB" id="10254927at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="41294" checksum="C054D970116C607C" modified="2014-10-29" version="1">MFQALVHRAGGLDKVVEKDVGPLILQAFASNSTQVIDFLICECNCDVPTAIDDVRLYSVMEVSVVHSSNVLFNTLFKLYCSRKNLEYVESPPNDQDDHVGRLYKSFSYAYNFVEQEEMFNPPAIDTEILNLLRKSFKNTNIHAALLLMKVARMDINRFTYPFIVKSMEESKLKDVAVHWECEDNLINLIDAMDDPSRTDPNGKTLLHIALENNCFRIVQYLIDKEMFPLHQADTINRWSAFHYCLMEQSTIEKKYQKIQYELETRRKLFTHMMEKDPIDCITSRDAAGRNLLHLAVINGHYSQANDMLEPILKDCTPEELESKVTSILSQSSVTETARFNFNLKRLEKIDSGFYCIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIT3</accession>
    <name>A0A084VIT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dpse\GA13699-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005194</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013400">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005194-RA">
        <property type="protein sequence ID" value="ASIC005194-PA"/>
        <property type="gene ID" value="ASIC005194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005194"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="12290" checksum="19996181AE4E8EE1" modified="2014-10-29" version="1">MKRRHEELYEHGKLIEQKKQELREAAEAERQANAKKFKARPVPTFPKPTSRIRYGKPTTRPVTPEVLLRSFPSAPPFDRNRTLRDLKKPEKLSKAEKRTNDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ74</accession>
    <name>A0A084VJ74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMC_N domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524860">
        <property type="protein sequence ID" value="KFB38018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ74"/>
    <dbReference type="STRING" id="74873.A0A084VJ74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005285-RA">
        <property type="protein sequence ID" value="ASIC005285-PA"/>
        <property type="gene ID" value="ASIC005285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005285"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002524"/>
    <dbReference type="OMA" id="HTANIGH"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="283" mass="32498" checksum="17640F12B6DD02AF" modified="2014-10-29" version="1">MDASATDENEATKKQDLEKRLDECSCKIDDLGALPTIDRMYFAWPQHRLTKELEKVKKQLKQVANINPKVQDEYNVKLRMLADADKRLDELQRVKSSIQTLLNNLEIQRNDTVRRTFESVNNNFGQIFQRFVPGGKGNLILNSRNMEGQKNESDTMDRYVGLGIEVSFVGSKAKMSEMNQLSGGQKTVVAVALIFAIQQFKPAPFYLFDEIDQALDERYRVSLADQIHEMSRSSQFITTTFRKELLAHAAKLYGVWCRNKVSYISEVPKNQAYDFITDAEVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKS4</accession>
    <name>A0A084VKS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP003111-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00005942</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524949">
        <property type="protein sequence ID" value="KFB38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKS4"/>
    <dbReference type="STRING" id="74873.A0A084VKS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005942-RA">
        <property type="protein sequence ID" value="ASIC005942-PA"/>
        <property type="gene ID" value="ASIC005942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005942"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022968"/>
    <dbReference type="OMA" id="KMDHYVL"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="825" mass="93403" checksum="735F2F973138F259" modified="2014-10-29" version="1">MLVNVHMNGDDEIDVVPIDALVLENEVQEDDDSDGDSTESLDSDPELVQTKDGRLLLSRSSKNCPKCKKPLKTSAELEAHRPKCPGTLDKVTEVILKEKKAAKHANPSEEFRKYCNPNPENPCYCCGEDVSTAHVGHIRCQFCPKSFKAFEYLDRHIGSIHAESDKFPCNFCNAKCPSDEILEEHKKTHSEGKPYSCTICGKEFTRRYHLDRHAKHSNCGSDQKFTLPCEVCGKEFTRVDNLREHLRTHLGQTGRKRDYQCPYCPKSFYGSSLLNIHIRTHTGEKPFPCDLCPKSFPSSGALRKHRRKHTGERPYKCDDCGATFSARETLNRHRKRHTGDKRHECKECGKRFIQATQLRTHMFVHTGDASYKCKECDQAFARSSKLNEHVKYEHRGEKPFECNECGKYFLDRAELTRHMAVHTTQKEFQCHCGNSYTRKASLKAHMKTHSTEEPVNCKICSKTFIRTDCLLRHMKKQHVEAVEELIQSTEKRKVEELQVPSPATVEINGEVFEITTMGESAKEPTFVLPDSGDGQELEVYELPPIGDSETVAPTEEPVEYELVPIAEETEVEIYSQEQAHDDFSPGNSEGVEILPTVKKYSPKAKTNPAKSKTESASSSRRKPEEPADDTSPEQEPNPEPKPKPAVKMETAKGKPSIPSKKSDKLPTQPTPVEEMAKEIEPKSSRAAETPVDGVMEPTAKRRKTREPKTATGTKRKRTETDDSIPIFLSDEKLAEKIAELLLMLVGEEMLQEFGWPETPVEDLLCQVILRCGHRPTKGEEAGDNTTRMRENTKILFSVTMDEEDIKPLLNNHTVDEVIMHVLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL35</accession>
    <name>A0A084VL35_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">eEF1A lysine and N-terminal methyltransferase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006074</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54196"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="Rhea" id="RHEA-COMP:13827"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:58440"/>
            <dbReference type="Rhea" id="RHEA-COMP:15140"/>
            <dbReference type="Rhea" id="RHEA-COMP:15143"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142597"/>
            <dbReference type="ChEBI" id="CHEBI:142600"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014403">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL35"/>
    <dbReference type="STRING" id="74873.A0A084VL35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006074-RA">
        <property type="protein sequence ID" value="ASIC006074-PA"/>
        <property type="gene ID" value="ASIC006074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006074"/>
    <dbReference type="OMA" id="FEWYGAF"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000462">
        <property type="entry name" value="Methyltransferase-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000110">
        <property type="entry name" value="methyltransferase-like protein 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="678" mass="75391" checksum="8476BBB8427949E9" modified="2014-10-29" version="1">MNLLPKSTADFGSTEYWNSFFRKRGKQAFEWYGEYPELCGQLHKYIKPKDEILVVGCGNSKLSVDLYDVGFKKITNIDISPVVIKQMQEANRTQRPEMTWCQMDATAMTLPDESFSVVLDKGTLDALFTDQSEEVVGTVRRYFQEIGRVLRSGGRYVCISLLQEHILREVVEHFPSHHFMLRIVRCPDAGGRGTSEAAAADGSSLVVFAIVATKFKNLPMRVLELCMAGDQMERVQQPEDMIGAVAAAQKAAMYRRDGRSIDRSVPSERKQTPRYTIHVLDQAPKRGSGKYAAFIVPQGRETEWLFATPQGRQKLQASANFDRLAVVTLHRGHVYTDLEAVKVELAESVKSLAPSGLQGASIPYLSIGAEVGRRETIHTGRSEHSGEYVVEEIVGDNGRTFRRLIFLATPAVVQSEAALKMARVRGSRAPQKVVDPGYLACQHHLFMTVGVQLATRLTQKTTSPPSSLSSSAAASVAVIGLGGGGLCTFIRECLKASTITAVEIDPEIERIAVKYFGLTLDNRLRVVIEDGIRFLAEEANRGAHYSAVLFDVDSKDPTVGMSCPPAIFVERNVLAHVRKLVGDEGLFVLNLVCRNDALRETTVRSLRESFKYVLSYKLEEDVNEVFYCTDNEGLKDATNWQKELREAANDVNKLARKEKLTHEQELVDLSDFVSALQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLA4</accession>
    <name>A0A084VLA4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome P450 6k1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006148</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLA4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006148-RA">
        <property type="protein sequence ID" value="ASIC006148-PA"/>
        <property type="gene ID" value="ASIC006148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006148"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="22597" checksum="1635AD939FFF042B" modified="2014-10-29" version="1">MDRYKTGLRLKANNGTVALIMTQTLQRTIQSNGTLLARTHSRALAQKLEQAWMHHFAHKATPDLRRPNLVNSRKLSQPELYRTERHLHIVFSTASTLQCALRGDYTDTPDSTICTDSRPISNCGRTGLVRSLLMRFAIGGWRRPDRIGSPSTVHICYRVLLGSFWGDALEREGGGQRNTISPQNCPIHVRPQNNTRQGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM47</accession>
    <name>A0A084VM47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006752</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006752-RA">
        <property type="protein sequence ID" value="ASIC006752-PA"/>
        <property type="gene ID" value="ASIC006752"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006752"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006752-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8129" checksum="09BCAEBBF229B55A" modified="2014-10-29" version="1">MEYKSSKLPSDRADTLSDYAVCPAFPTDRFPVRVANRTNGSKRRLVSQPTGCLTDRPEAIESIAVIVQTQSATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMA3</accession>
    <name>A0A084VMA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006423</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMA3"/>
    <dbReference type="STRING" id="74873.A0A084VMA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006423-RA">
        <property type="protein sequence ID" value="ASIC006423-PA"/>
        <property type="gene ID" value="ASIC006423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006423"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012489"/>
    <dbReference type="OMA" id="LELCIGH"/>
    <dbReference type="OrthoDB" id="7752744at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="595" mass="68074" checksum="7433E6B7A2E2BB75" modified="2014-10-29" version="1">MVITVSSLIERKLYAPVWKVSDNRTNMTVERVDTFYDLDTIYSTIERMLILIRQLSGVSRFGENGRSLSFELQWMNAIDERKYQIEELRSAVQYLFGQFRKIYLVNKDLYAQLNKRGGRVFELEKTIEAQGDSKCLYFLADAIKYEPALLAMQRVLDRTMREIRIFRTQRNQHKLELCIGHIRSENYDKVYDEYCSSESGLQQLPRIIEAVFERDMKNLMKILLFLSGYRKLNKANSAETFVSGCEFLVQHLRECGDLADHPQCLLIYGFVVDALQERPELSVASLLEDVFRHRLETVRTSLVGSVQRTVRLIQTDPSATASLGRLAHHLADEILIELLKRAYDGDVRNLSNILRFVAHLSRIDHDIVAYRVLYAQMEHYDHLDRPEVFMLAYRIKQTMQAPTFPTASLRGDLERLKASLPPIVVSIMWKTVTIARHESRILLKFSAVGRDVGFSRYTADKNRVELEPLEDGACFRIRGHAINGYLGEGGTGAPIVAPKADSLSNAKFRWRLVPVQGFEYFRVQNAASGAILYSRVPSDETSYDFYNSQEVLQLTGNERILTAQNSYWKITEYPRRSGSGSSGGSGAGDSECCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMP0</accession>
    <name>A0A084VMP0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006578</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VMP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006578-RA">
        <property type="protein sequence ID" value="ASIC006578-PA"/>
        <property type="gene ID" value="ASIC006578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006578"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019605"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019891"/>
    <dbReference type="OMA" id="FLNPCYG"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF2">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783865" evidence="1">
        <location>
            <begin position="33"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1395" mass="152810" checksum="2E62173C4717B61C" modified="2014-10-29" version="1">MGPLLGSSSVSRWFTVGWLLLATVTLLCTVDASPDSSQGTVRKRVLLDRTPVLPDKVRLLAECGAGQNCTRTCPENYALDSRQQYCRPKRQGSCPPGYVQRAVGGGCVLEDIQCPPGSTREGSRCVIRSYSCPPGYASKGTSCVRDSICQPGYRWENGLCFPAGARIFCPPGYTEQRTGNCAPAACADCCDCQDETVATICPPGYSNHWGRCVRLLQASPDLRISSVMYRLPVECRATGETFNEGRCEAWSVVGRPACRSGHFYNGSCVEVARCHRGTLNNVCSCEFEQHLAATCPIGKLQEQVPGSCVVSKVHCRPPGRLRNGVCVRESKARSTCPEGVPFQREYCAIDVPRCPRGFTLDDHGLCKKMTPCRMDCGPYQKHGSWCGLTASCPEGYILNDHGYCVRETVHPAYSCPPGTNEHGPECISETPLCRSNYNYNPSVNLCVRCDEQPIQCPRGNLTGGRCEWSEQACPSGYQWSEGMCIKSGNDSRKYRCRKGYEFENLCVHGELACPGGHELLGESCVVKEDVHCPDGSYPLDGRCSVAKECPEHFQAGSDACIREVRRLINSTRPVCPGGFEYDGEVCISRTTVEASVTRRDAICPEGYERRSGDCVRTIQTFAVCPPRTIYTDRNDRCYCEVDLMCPHGYERSGTDCTFRSAGYTPFVNFLNPCYGAFCANLYCLSQCLSPPCPFEPCADHPGASPVSSLPRPPAYGPASCLTGGQQDCPPQEVIGLVCPPGYERVNSSCFAYYDKRCPDGYDTIGGSPGVGCSRDVILHPICPPGYTRDGESCFQASCPNGFKLQGTTCEKRELRSPKPCPPGSDLFRGACYRRSACRNGTIDGSYCVEREFTRPTCPEGFVQRSEDCAIEGSCSTDSIYIDGACVRFTEPATCPDGTYRLGRLCVYPDPPECEDTPFVATDCTSEVDARGRCWRSTIPVCAKGYQLLDDRCVSCQTEQPSCPPNMTIQRREVCVADRVVCREGYFLRAGQCVKLHVARPRCPSEEYGLCGGFCIVAHTHECKESEYAAPACTKGFQHQGKCVQLGRCDAEYTLLHGECHLRTFADPSCHGKGTRVGALCVGGTPQCPPNYALMGGQCYSCLIENAHCASGATCSESFCQLDAPRCTTSGSIFDGQVCRQLTSNKPSCPAGTNPDRYDTNFCHLKSEKAIYNCPDEYHYQNGVCLKKLYKTPACPEGYKLRHGVCYKRVCTRMSSGSSCSDGLAVHAANTCTQCLNGTTSSTPSNDDPAATQGTVDLCCSVFSPRICQASGLCHHERETICGSFCFTEEDNIYLTVAHSIQIGSRWYLAPRRIDDEDDEGSGESGYKVDIQWNYNPQSNRNVMECSRCIVQPDDCPKHCNTYDCQAAEEECNFTDASTFCAQYRDGKICENMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNE1</accession>
    <name>A0A084VNE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008042-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ATLV01014737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNE1"/>
    <dbReference type="STRING" id="74873.A0A084VNE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006980-RA">
        <property type="protein sequence ID" value="ASIC006980-PA"/>
        <property type="gene ID" value="ASIC006980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006980"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023791"/>
    <dbReference type="OMA" id="MCENLIL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="265"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB39485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="492" mass="54606" checksum="F78E35F4A021659B" modified="2014-10-29" version="1">MSDDLCCTYLIVGGGIAGVTCAETLALLRTNPSERILLLNESSLVKAVTNVVPLGKVLNRFDVEEKDAQELTANSQVDVLLDQLDTIVSEHHYVRTVAGRCIKYRFLCLCTGARPNIIDKAKGNANVIGIRDTESVQQFQKRIHTASRLVVVGNGGIASELVYEVGGMEEIHWVIKDAYISSTFVDSGAATFFRERLGKKEKDEGAKPIYKRMRYVEENNLEQTSTVGDADSSNFASNKRGAALGPDWHRAFDIRKHGENLPNAGKVTVHHSVEIEAISDRSNGEKFPLLVRLTDGTEIECNLVVSATGVVPAISWEGGCDRPFKLGPDGGLFVDWSMRTSVKDVYAAGDVCYAGWEHAPHWFQMRLWTQARQMGAMAARSMAARRAGEEIYQDFCFEMFNHVTTLFGYQVVLLGRYNGQGLNDKYEVLLRMTPGLEYIKFVLVNGRLQGALLVGETGLEETCENLILNQLDLSPYGEELLNPDIDIEDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNH0</accession>
    <name>A0A084VNH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006855</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014752">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNH0"/>
    <dbReference type="STRING" id="74873.A0A084VNH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006855-RA">
        <property type="protein sequence ID" value="ASIC006855-PA"/>
        <property type="gene ID" value="ASIC006855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006855"/>
    <dbReference type="OMA" id="RSEREFM"/>
    <dbReference type="OrthoDB" id="7736400at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="250" mass="28634" checksum="08B822219BB220E5" modified="2014-10-29" version="1">MDEVTAIFGAPGRVITDRGTAFTARKFEDYCLANNISHTKTAVGSPRANGQVERSNRTVLNAIRCMVGEKTTRWDEQLPKIQWSVNNMPNATTRVTPSSLVLSYRPRDIHQNVVILALQQEENNVVEDAAELREQAIRAIEKGQRTQKRYFDGHRRKPVSYEVGDMVLVERDLTAMGHSRKLEQRFKGPYVVRKVLGNERYELEEIHERQGRGRVRTTVYAADRIKRWGQLEDLEGCEEAMGDEDSESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ10</accession>
    <name>A0A084VQ10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">G-patch domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007514</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007514-RA">
        <property type="protein sequence ID" value="ASIC007514-PA"/>
        <property type="gene ID" value="ASIC007514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007514"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007514-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7558" checksum="75265A6CB46DB01B" modified="2014-10-29" version="1">MQSPLEEEAKRAGHCTTNNNRSLLVDERSFNPDGEDPCAMCSFRSNKCYRRDIDRVESEIAPEQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRP4</accession>
    <name>A0A084VRP4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRP4"/>
    <dbReference type="STRING" id="74873.A0A084VRP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008200-RA">
        <property type="protein sequence ID" value="ASIC008200-PA"/>
        <property type="gene ID" value="ASIC008200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008200"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015347"/>
    <dbReference type="OMA" id="YGHVRYL"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF167">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="183"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008200-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="356" mass="39502" checksum="8AC7ABB3F8F7CB0C" modified="2014-10-29" version="1">MPKEKTSKHVKCDILFDNNSSGIFTAGDHVAGTIELHLTKIKKVRGVCLLISGYSSVFWEAKVPDGPKNKKVKAQFKGREDFIKQKLYLAGSENGTGIQLPPNAIRYKFDFAIPPSAPTSMEGKYGHVRYLLQVTLERPWKFDHKFQKPFTVTCEADLNKNNEVLCIPTKAEDMLTFYCGFCRSRPLMVSATTPKSGYAPGETIELELFVQNSSKVAVSEIEIKFRKVLTFTSQTRTIGQTQIQAEEKNIQHEVLEVRKIPTIEGENDARFVENFVVGPVPSSETTHSRIVHVSYELAIVVKPQASTKRMKLTIPITIGKIPLAGSAMPYSVSGGIQKLTSSLAAQDCSAPPAYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSD9</accession>
    <name>A0A084VSD9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008410</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSD9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008410-RA">
        <property type="protein sequence ID" value="ASIC008410-PA"/>
        <property type="gene ID" value="ASIC008410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008410"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010145"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9128" checksum="08A80A1C8EF88041" modified="2014-10-29" version="1">MCCPRLRGKVLPKRMHTESSLELHQKKPNGVVQMVLSGLVCGYNGSEQITTVSCGKLCGGMHRGSSIGNRFDEGALTEATGSLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSM6</accession>
    <name>A0A084VSM6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00008629</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="ATLV01016091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSM6"/>
    <dbReference type="STRING" id="74873.A0A084VSM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008629-RA">
        <property type="protein sequence ID" value="ASIC008629-PA"/>
        <property type="gene ID" value="ASIC008629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008629"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020008"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008629-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="347" mass="38965" checksum="FA8E96FAA780BC82" modified="2014-10-29" version="1">MSDGDADVAPKRNFVVPEKLIKSAADMEKWEKSEAYYDVIGFISSMAVALQGTRNSQNVTMPPVVENLSNVLDRLEKLAIETPPIDQPARFGNAAFKVWFQKVQAESMKLVTDALPDNLKDAAQELQVYFVESFGNATRIDYGTGHELAFVMFLMCLFKIGAIERKDEVAVGLKLFQKYIVLARKLQVTYRMEPAGSHGVWSLDDFQFIPFIWGSAQLAVNSPIEPAQFVEDKTIDKYKKELMFIGCIDYIRQVKTGHFAEHSNQLWSISAVPQWSKISTGLIKMYQKEVLSKFPVIQHVYFGSILTLQPVKPGTVLPNPRLGMIPRQPANVPAAPMPPKFEAGDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSM8</accession>
    <name>A0A084VSM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008654-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008651</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSM8"/>
    <dbReference type="STRING" id="74873.A0A084VSM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008651-RA">
        <property type="protein sequence ID" value="ASIC008651-PA"/>
        <property type="gene ID" value="ASIC008651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008651"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011511"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140954" checksum="34E40F17785D661A" modified="2014-10-29" version="1">MLQLNASFIDGEECYSGARVRRQIRSPQGGAEVVLFTEIPVEHRPRVLIQMSHPVYTPGDYVKYRILLTDGLTKPLDKSTGSLPVTIALRHTTQHTVGSWVVQLDPGAVYNGQYLLTDDRDLGDWNLTATVDGQTTTKPFEVRHYSAPVHQISVEVDRMDMDKLKLNINANYIFGKPMQGTMTVTISGGDVPFSPIQKPISEQGKVMLLIPMEQIFDLGEDEFPAPPDVRVITVTVTVETSNGISSRTYHHTKPITVHPDNHQLTLHRMVGFDPEQNATLLVKLTPLSKNTILVDRQVTVSTQLWDEDENMILREDTFTRTVEKDGTAVLSVPTTDATTSVIFAVEYKALKSSFTVESSYNPELYVRILPAEVRASLTLGIASSHRLDGYVVVVRNHTGEVLDRIVIHESDSQESYFEYDLRRTGGLKNVHLFAKVNDGDRLVQTSISHEEPRLPSKSSISLEETNKSHEITVNTLSNLGVVGIAVYEGLLDWGNIDQINRYMMFNGSLYATPDEFFAEYANQVFITPSVKPDPSEPRSQLSEQPSTKFNQLLLWQHNASADPKFEFKIPAHVSQLTVTAFTFSSTTGLDVPVPIYWERNDVIKIHIHAPYSARKLEPVMVDVYVVNNRDRRINFLLVELQNTANEFQFLNNSGRIDAVKKTVFGSLEAMEVQRVEFLIKPKKLGPIVLKAIAYTLDDVFAMDETVLRTVPESELKTETIMRPFSIQGSVMKVSEKLSIPPMVDQGTEKITLELRHEQNQMATLPASLLLDPLVQADPFTMAVKASLTLDVLRMGEIHWPELDAEANAMVADSLDKMKGLVKPDGSFEIEGYRPGSFAACWGTIVAAKALTFAQPHSRDVKDSSGKALMDALAWLKGRQANDGHFCGGEVLDTEQRVEVTSQALLAFSSTGKHSWQYQTVINNARGYLRSTVTVLNDPYHLALVAYAMQYSARIKTGMETDAYLSETVNYALEALWVHKKTSPSQNFVWWDSPSNRSLEATSYTLLMLTSKKLLLESAPLVNWIKRQSYRRMPPVVTPDSHVALRALMSYAEHTTFLHQEYTAVVVAKDRSREIYNATLQRYSATHVLTLPPTTRSVSFTINGTITGTMQIIYSYMENVAQHRSRFNLQIVRYDESDMDYVYWGICVRFQPRRSLERTRMVTCEFSFPSGYIALDDSVEELQGLDEIVSVTTRNKETVLAVTFEEITVQGRCFNVTGFRRKRLDKVLPGELKVFDVTDPCKCWILLLCFAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT20</accession>
    <name>A0A084VT20_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008573</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT20"/>
    <dbReference type="STRING" id="74873.A0A084VT20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008573-RA">
        <property type="protein sequence ID" value="ASIC008573-PA"/>
        <property type="gene ID" value="ASIC008573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008573"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008390"/>
    <dbReference type="OMA" id="GYDTLKC"/>
    <dbReference type="OrthoDB" id="6158299at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008573-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1242" mass="134363" checksum="D0C215ADDF34D81D" modified="2014-10-29" version="1">MTNDDSCSASDAGNNVVAMASNGSGDGDVVSKHQQQRKHAKQQQQRQGLRDESLRRLVDGQVRRKQRPGSAAILEGVIGPKAHLKLVSQELEWERKFRDDQLSRILKALIAFETRLKNEQTRIKQQLYEKDDVINRQNCTINRMKRKLAADETAGSDDGEEETTIDEVAQYCPKCRKNYYRLECRTNGTQTFEYCREDGAESVNTENLSLNSVEYASSSEEQESSLYVRANSFKDARRSRKYTSKRSYQGYQQRGTASRASSFKSNASGPTTGRTLAKLTERNEGRDAIRLQRGGSAAADDDDAESGHEAYVNIEPNANVPKIVIYENYESDKENKRLDQNQRPRECNNYDNVEPYSNRIDTLHGIHAGRFGKQHADGRNDYHLASPSKRGSVDGSEEQMELDDGTVFYEANTTGGGGNNQAKYTEGMEMKQTIETNDDWYASASDMEDSDTALGKPYSNAAVNPVLECVNQILLQQSMDGFGDSNKDTTTNGDGNAVGEEDELYIKAQELPSQQQQQQPAPVKAPSTTVRSKRVHFSTQNSMVQVPRITTGPTILGAGSGNRKDDKLSPTYEIQSIYSNEYEPIGSEQNSYSNYYVDMESKLGSEDREREMALAEKRKTPPALPPKPANLLKLQQLSKTNQRGGGGGGGVLIGGSALKGTARHAPSSSAQSDIAESEPDYCSISEIQDSVKCVQIVAEIHKDACEDDYSIVDEEETGPVGEKREQNGTEATAEEKPVETGSRKSSSELEESFADVPKLPNVAEIVVPPKKDSLNKFISQDNYITKSSSSGSSTTSGKVMLSSGSMPNGGGPVQTTPSKKDGEFREQLSEIIAEINKQSPAIRTASKKQIPVKDLGSPFRGVSQIPGVSFQSKLKPVDKLSFLSKGSSGSIPSLNHHHHTPKLTTATTTTSAIGRPAIKPTLLKSSLSTKALSSTNLSLGNNLNQFGSPVKSVSYIPNLKSLNATGPRENGGSSSVSCSPVKSSSPVKKAPERVTGTPVVSAGGTPTSSTPVIIAEDSKLPIQAEFDWYNLDAEYGKSNQPDVIVEADPCTPGSEPPTGAGTVVEEQDATSNRSNSGQVNGTQGSVKGAQNKSLPTPNGGHSKAIGSAGENGTTECHEDEELENVEYNLDEEYKSIGPIVPPPDIIQKGAPPPPLTPPKNGKIPYNSLSFKELMQLNETPKIGPEKGKAKTAAPTTGGGTGGTENGGPTTGNYEHFLDDSGLCSKPIILPRKKRVYYSGPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUS7</accession>
    <name>A0A084VUS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009352</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017008">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525142">
        <property type="protein sequence ID" value="KFB41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009352-RA">
        <property type="protein sequence ID" value="ASIC009352-PA"/>
        <property type="gene ID" value="ASIC009352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009352"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7154" checksum="812654620AFE2065" modified="2014-10-29" version="1">MAIIVFHPSLAAPRPAEPEDIPLFVRTSRANPQGSPYGRINSGSPLPRPASRGMNRTGNKARFVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV03</accession>
    <name>A0A084VV03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009712</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017139">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009712-RA">
        <property type="protein sequence ID" value="ASIC009712-PA"/>
        <property type="gene ID" value="ASIC009712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009712"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8488" checksum="2F1A882AC945F804" modified="2014-10-29" version="1">MDRWKTLPASVQLVGTVSSAAASAPEDQDQPFPPTAIGIPGAFVSTNLPASAIANRLVLIRVCGVLVRSIPTIVYQLEDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV88</accession>
    <name>A0A084VV88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">HEAT repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009728</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009728-RA">
        <property type="protein sequence ID" value="ASIC009728-PA"/>
        <property type="gene ID" value="ASIC009728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009728"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="18381" checksum="9A53E134904C36A7" modified="2014-10-29" version="1">MVRPVRDEFFERVLFRNDTFKRRTASDNRGCVRKMATGDPLSSPSSRDPRSTNTPVARSNRCKRFPPGGGTGSNSFTTIFETPFPFEDRRSGDSRKSGARYITMPPNRQMCPCHLSTLGFSLALSQRNVLTTMKSNMSTSSVRSGARDSVERNKLVMCVLCKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV96</accession>
    <name>A0A084VV96_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009449</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="ATLV01017165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV96"/>
    <dbReference type="STRING" id="74873.A0A084VV96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009449-RA">
        <property type="protein sequence ID" value="ASIC009449-PA"/>
        <property type="gene ID" value="ASIC009449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009449"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016491"/>
    <dbReference type="OMA" id="NMIDNDK"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043052">
        <property type="term" value="P:thermotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20855">
        <property type="entry name" value="C1_DGK_typeIV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000204">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000012">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000020">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF80">
        <property type="entry name" value="EYE-SPECIFIC DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DAGKc" evidence="14">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="761"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="839" mass="93064" checksum="D7FB158337F0CA46" modified="2014-10-29" version="1">MERNEPLCKPTFCDVDVRQYREQTKISHHWVHCRMGKGKCKQCGKALQGKLSFGSKETVAVSCAWCKHSYHNKDSCFNPERTGEECDLGKHRSIVVPTSWIVKLPPKGNFKSSLRKALQKRKKANKKPQEAEEPRTFIIKPIPTANITPVLVFINPKSGGNQGAKLLQKFQWLLNPRQVFDLTQGGPRMGLELFRKVPQLRVLACGGDGTVGWVLSVLDQINFSPPPAVGVLPLGTGNDLARSLGWGGGYTDEPIGKILENIGSSDTILLDRWNLKVTPNEAATEKAADGKENLPLNVVNNYFSLGVDAHIALEFHEAREAHPEKFNSRLRNKMFYGQAGGKDLLKRKWKGLAEFVKLECDGKDLTPKLKEHKVHAIVFLNINSYGGGTHPWNKSGGQFEPATDDGMIEVVGLTTYQLPLLQAGGHGTCIAQCKSATIVTSKTIPMQVDGEACKLKPSTIELTLLNKAVMLAKKKPGRANVPLEKLESLNVKLAKIIMSDYEQHHYDKELLRQAAVDLGTLDLPVTDLEQLRNIINKFSEEQPDSPKLSSDWCFIDSCTAERFFRIDRAQEHLHFLTDIATDCLFVLEQECPTMPQTPQKEFSSTPKSQISLESIANGESSKIGVSSPSNVKLHGLSLDETVAMDPKKSDARDLHEPSSNRKLPERGVSADNFGIDQSLDQVVNFKSNLLEKTTDVLIRAAKTGNLALLKELHFQGYSLLSIDSTGQTALHHGARGGHKDIVRYLISYAPNTIINMIDNESGQTALHKAVANKHRSICYMLVAGGANLNIQDQKGQTVRMLAAKMDDYELESYLEISTERLPKQHMRPDGGVRRCIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVF4</accession>
    <name>A0A084VVF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013464-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017174">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009513-RA">
        <property type="protein sequence ID" value="ASIC009513-PA"/>
        <property type="gene ID" value="ASIC009513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009513"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003020"/>
    <dbReference type="OMA" id="QLRCHIL"/>
    <dbReference type="OrthoDB" id="7488383at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784102" evidence="2">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009513-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="473" mass="49368" checksum="88CD9FE406578E09" modified="2014-10-29" version="1">MVCLVLVLLCGVPFLVAHPSNQPADTTSPDQRHLLRQIGTLGLLVGAVEVEAAIEARLEHLLKELEQSRPQDVTRRLATIDRTLERAQLSLEILGAGLDLTAADTRRIPSAQLQLRRELQKRAQQVLGRRSRAVARVGNGTSTQVKRQVERQLVEMRRQLAPRIERSVRQLEQQMQQKQPGELKLTLTATVGTETIQRLLAQTLPQAGIRLSDLVRNGLQGEKDDAKDDDEREDSGQKGTNELAVSVDGVGEKSESQESEASESSEEGPGGLVGLIAGLSGGDEGSDVGALIGTLSALVTNLFGPGGLDVPGLLGTGTSLIAGLLGGDDNFGKVLGSYVGIAIEGLSGGGADMNGAFFGNFLGALIAALSSDPEDENLPLKPKLFVQNFFSGLEEAKRKEDPNADGEQCCQKGSDLFAFLGNIVSSVVGGVTSLVLNASLGSSGGSSQGSADASGASSAGSSGGGDHPTSTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVQ7</accession>
    <name>A0A084VVQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009634</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009634-RA">
        <property type="protein sequence ID" value="ASIC009634-PA"/>
        <property type="gene ID" value="ASIC009634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009634"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11707" checksum="7A73581EFC3EBDED" modified="2014-10-29" version="1">MKHEEVDLFADPLIPKCKLNSGVAYTHPRLNDLGAWSACWESNVDDCDKDDEDDVDGLPSDPRTPTAAHVPSRPGGRDASKDTAACRLALASEPDLPLRVHAPRKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWG9</accession>
    <name>A0A084VWG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009277-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009999-RA">
        <property type="protein sequence ID" value="ASIC009999-PA"/>
        <property type="gene ID" value="ASIC009999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009999"/>
    <dbReference type="OMA" id="IPLKGMN"/>
    <dbReference type="OrthoDB" id="7788728at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="237" mass="27436" checksum="1289BC4CBF4CD51A" modified="2014-10-29" version="1">MQDFFVTLEQYSWLTRITVATDLLNIPQRYDSSLVSRLSSCLEALELGSFNFSPLVINNITKHLIEDLPLQGVNLLYVIKKLAITNSKILYYVAVSLVFVGIEAITGASKSRYRLHTVDEFLKYLEVLNIEHLHSERHNLQIIYQLLKLLSLYENMVLVRHFGKQHADLESEHKCYANFFRVSDQQRMAFQLWLEKSSSLVRLSGNDRDVDYLILADLIEVDMLPLLDDVNPTEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX28</accession>
    <name>A0A084VX28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP000539-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00010230</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX28"/>
    <dbReference type="STRING" id="74873.A0A084VX28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010230-RA">
        <property type="protein sequence ID" value="ASIC010230-PA"/>
        <property type="gene ID" value="ASIC010230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010230"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002815"/>
    <dbReference type="OMA" id="MMPWDFF"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF89">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="927"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
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        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
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            <begin position="528"/>
            <end position="574"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42522.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141302" checksum="2961F0D444EBAAD9" modified="2014-10-29" version="1">MDWGDRLVLIMFLGVFLRQGGALAVSGIYVNNQKIDKFEADRIKLLHPARPSSSINQTPSSSVGKDELLTKDNFTNAQHYYQYLVGANPASYIDLLWGRNKTHFPSLLRVGAPSLGFNWHSDDEQSSIKNTLNNSSPVYIGDYQHVQLPVLLPSTSTRAPSSRPTRRFKKRPKPKPTPEPQRVQVSPGGKNELSPETLALLSRYYSFSCTLVPKQRSQLVVTTTMPPTTTRKLKTRRLTTQRPITAMTTSRPTTSSSTGKRKKTTVYVDPPVINRIGGMLESVYNFMENALTSTEYVPDSKETGAAGVSKADPQEHLRSVPTSSTKVKRNTRNITSAISDILARIGDSSGGSTELDSDTRITSQWLSTTTESSSESSKRFTPDRVTISGLPTIVSEGNKNKMTTNIQVTSEYTAATPPTVPVRKPSSSSDENDEDSSEEESEEDYFGGFDGFSEDDEEEDDDEDDDDQSKDDDSEELGRPGGQGVLVNDKDYDEDDDGEDGTQAGQPVRIKRVKKRRRKKRPASSYEDTAEYSDEDDGSSDEEGEYDDRDAPSGDDDEEDDDDYESGEAPDDAAEGFFGGLFSTFGRFVRSLGFGGAARGTPEEYDDYDEGGGRSTTPRVLDTKRRPTRSTSNGVDGPATQIERDPDVTSPERSPPSWLNLPPSYLFNEIGDDPIEVPVQEELTVLEAPVPPTPETPTSVDTSSSWFDLMMPWDFFNPWTHDDAENAVQEAILTTEAPLTLAAPTQPPEVETSTPTSAPAAGSNWLSQFFVGSPTTTKPPKPRPKPPKAPQAEQLVAALAQYLVAARPTPQSTPKPRRKKSYAGYQLWRVSVQSSEHLQRLVDFQRSPEGLQLQWWSGPSLYEPTDVLVPPGAVAENFHDYLSEDGIQYEPTIRDLGRAIAYENPRMTRREQIENEVLHGHPMTWFRYHRYADIVKYLDYLGRRHSQQVRLLHIGRSYEGRPLTVVRVSLPPPARRSARSATKKRRPAVFIEAGAHGHQWVGPAVATWLLQRLLEPSNSTAEQETIRSYDWYVLPVANPDGYEYSHEHDRMWSKSRSRPDHRPQPGFGQTLLSSALSWWSNAQTTASRDRSSETCYGVDLDHNWAHRWQDTPESSRSECSATYAGPAAFSEPETRAVRDLLLTGRARNVRIFLSLQAYGQTLSYPNDGDDTSTRHGAYAFGDVHEMAAVGLEAMRGAGGELPYTLERPGSANRGPERGGTSTGYARYAAGIRYSYTLRLPDTGTHGFLFPPSNIVSTGRDTFELIKGMMDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX92</accession>
    <name>A0A084VX92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010303</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017870">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010303-RA">
        <property type="protein sequence ID" value="ASIC010303-PA"/>
        <property type="gene ID" value="ASIC010303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010303"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="12998" checksum="148852183334A548" modified="2014-10-29" version="1">MKSCIVRSNKLRDVSECGWETFKVTAGGSGRFGKCFLCFGFVPTSSFRWRGSRLRVTRDGSVFTGSPEAAYTKCPRAASYFHSVSVRIFCFCALTHASGRNVRVAGTGICHGCNHPCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXP0</accession>
    <name>A0A084VXP0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion channel nompc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525213">
        <property type="protein sequence ID" value="KFB42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VXP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010476-RA">
        <property type="protein sequence ID" value="ASIC010476-PA"/>
        <property type="gene ID" value="ASIC010476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010476"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001555"/>
    <dbReference type="OMA" id="NYLYQYQ"/>
    <dbReference type="OrthoDB" id="7729168at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF83">
        <property type="entry name" value="SOCS BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1424"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1490"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1640" mass="189437" checksum="EB4CD975FDE021D9" modified="2014-10-29" version="1">MTQPSNYVSKYAGEYCKLVVEGDIGKVKSKFKEFVLDYQTPEDLNTPLHLSIIAQQNRNEIIQFLVESGADCDLRNSMNLTASELAINLNFIDVTKFMLAVEFRNLTDYRCFYRLIRRGSVPLLQLFLELKTFDIHQQIGYVSSVWHELYVKNVPLTKSMENFLEYQLLNYSYAYHHPPAHRPDRQKFDREYERRIELIVEYTRYLTEHYDATDNLNDFDDKFLLAIKIVYDNLFFLREKRDQLAQVPLDEICRVLAVFLAIFKKSPHYEVYKLILNKRTVLRYLAAVSEELEKFRLALVERGAQPKWTVDQLLSLIACIRDAAPAKSTKAINALWQKRCVLKKKLIYYVKGRLKANPELNAIQARHSNNLSKAELEVIRQEMKAKQFLNLTRTVSRKNQVVFQRLRKTYDHVVQLYAIKKILRYLDGISRIQLPQYQVSGVLAIKRTLQVIAETVESARYCPSIARKLHSVVHKILPLNLDVDVRDFYQPNVSLYKLCSDKLESGRLIPFAEVQCSLKSVRRYFAYVHDRKMLEAYKCYLGNVYQLRNHRQVASYNQYVGDANRMYFENHTLDDLYFELEDCIRVVEELQETFCQQQDEKISDLLRCLYGPLAQRYEVLTKGDASRSALASVSANFNTTMMLCGTEIDVVKVRRIVGSFLAERCPKYDICTDDQLLLVGPILQELLHLFTNYLYQYQMDERVTKNFITMVEVLHVGRYMAVDHFLPERAKPTDSLMHQNYTSDMLKKFNLQSLSSIEFAVLHEQLSASYYDNCYNLDKKYAVLTMFFKSTNRQVNDAIVKRNKRMDREEFQSFLDSKLKFIGQFLPCSDFNEVTQFINEAAPHVEFALEHCLMELCEILTDLGVFQDNQYVLKLQSANVSGRNLHEYLRRGDTLEHDMLTLTHSTKVKVFLNGLIFKSNEFKLYQPPSTQKANADELLAIVDNLTNNYKMRWSWVEQQERLFKSVETIDLKLLQALTPDYADIRGMRLGVLHPGTPATEYEIIDHTVRNNLKQMVDYLSDELAAISFEKQQFFQYVLVRSSNSLFIDAHFSLTTVQERQATILFMALYFRAYDVFLECVRRFELTVNLGKIVKYINLEFIEKIAKQMKDIGWNCQDGNGITVLDQCVQKGDLGAVKKLIKFGAEICAPTADGTSPLHRACSLGLSEIARLLVKQNAPLGTLNGADRLPLHYAIQYHENDLLPLLCPDDIDVDSDKHRLVKCAIKYDNLDGLKFLLDSRQAKLSTIDRHQNTVLHLCAIYGRTGILRYLYSEHLSTLKEEDLLNRRNASSKTALHIAVQMRRVAMVRFLLEQEAAGINPSLVDDAGLTAYEWAVQESSVRVMKQFAKHHAPLRSISNSRERESLPVSLAIEQRNVPVLKFLLRNGYSLSEETLCLIKAVYTRSLELVRFVVDHCKPSVHYRDPYDSTSLHVAIAIDCNEIAAYLIESGAEINAVSKFGDTPLHVATKHGNIVAARMLILKYAAIDERNTSGLTPLMQAMYSRNLEIMKLLIGAGANIDLLKLHLAEIEQISKIPTMHLFVDHYGLLEFMILQLQYDPNVRDARSQQSLLHKACYANNLQIVQFLVDWCRLQPEQQDANGRTPLAIANECKNYEVAEFLRGKKRKKSQIAPQRYFDPTGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY08</accession>
    <name>A0A084VY08_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010604</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010604-RA">
        <property type="protein sequence ID" value="ASIC010604-PA"/>
        <property type="gene ID" value="ASIC010604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010604"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="16506" checksum="13AF67250F55A178" modified="2014-10-29" version="1">MNREIIDSSLVVASGKLCSSAADGGLENEAFGGQSAALCMVSLRQLHAFHLKKAVHESRTGANGGDFADPRGVERENRLLGSGRCVKQTALEETEEKKLSTETALEPAGWTGATSKPVAWLINPSDVDRQSSVSVCCRKNIKTDGNDDDDDDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYI3</accession>
    <name>A0A084VYI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Type IV secretory pathway, VirB6 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010700-RA">
        <property type="protein sequence ID" value="ASIC010700-PA"/>
        <property type="gene ID" value="ASIC010700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010700"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13437" checksum="23F33774472342A6" modified="2014-10-29" version="1">MNSPTQKQTRFHALAGSGAVPIFPGWVGAFWGRLGRSSLGDANRWQTGHGNELLTPITSDTRLSVPAFAEVLLMSERAIKRRNRWEAGGVRTEDDGPCREFRHPRHPVPPPVGGGLGGLVWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYR5</accession>
    <name>A0A084VYR5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00010905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01018413">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525233">
        <property type="protein sequence ID" value="KFB43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYR5"/>
    <dbReference type="STRING" id="74873.A0A084VYR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010905-RA">
        <property type="protein sequence ID" value="ASIC010905-PA"/>
        <property type="gene ID" value="ASIC010905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010905"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002406"/>
    <dbReference type="OMA" id="CWNASED"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF42">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="180" mass="20532" checksum="E038B97A23F3AF69" modified="2014-10-29" version="1">MNVLHWHITDTQSFPVVLELVPEASEFGAYSAEAIYTQEDIEDLAQYAKYLGIRIILEFDAPSHAGNGWQWGPLQGLGDLALCINEQPWRSFCIEPPCGQLNPTNPNMYNVLQQLYWNFASMNNGEDILHMGGDEVFFGCWNASEDVVNYMRDHGMGRTENDFLELWNEFQVSFRTISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYZ3</accession>
    <name>A0A084VYZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Coiled-coil domain-containing protein 117-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010962</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018576">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010962-RA">
        <property type="protein sequence ID" value="ASIC010962-PA"/>
        <property type="gene ID" value="ASIC010962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010962"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010962-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6575" checksum="FBFAA114F89AE889" modified="2014-10-29" version="1">MHCFNERAKEGKENMVEGRDPESSKCLVWRSGPELNAEGPGCSGTAKGRIGGREKKDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ15</accession>
    <name>A0A084VZ15_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase B1, membrane-associated</fullName>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
            <ecNumber evidence="4">3.1.1.4</ecNumber>
            <ecNumber evidence="3">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="48" type="ORF">ZHAS_00011013</name>
    </gene>
    <organism evidence="48">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="48 50" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="49" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EC" id="3.1.1.4" evidence="4"/>
    <dbReference type="EC" id="3.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01018587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ15"/>
    <dbReference type="STRING" id="74873.A0A084VZ15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011013-RA">
        <property type="protein sequence ID" value="ASIC011013-PA"/>
        <property type="gene ID" value="ASIC011013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011013"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017580"/>
    <dbReference type="OMA" id="PFQAHVL"/>
    <dbReference type="OrthoDB" id="7723056at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="50" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 47" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="47">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784242" description="Phospholipase B1, membrane-associated" evidence="47">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="48">
        <source>
            <dbReference type="EMBL" id="KFB43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="49">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="414" mass="46527" checksum="FDC385E669576A37" modified="2014-10-29" version="1">MDIISLILLLQLGDSTLGQEEVTFLDSPPFLSIFRNLHELLFNTVGPNSENPIRLEKARSLGKIQTPIPESQPFPCPTEGMRSVKPPNSVHNLRPGDIDVIAALGDSLTAGTGVLATEVLELVIENRGLSWSIGGQGTWRQYLTLPNILKEFNPNLNGYVVADSLSIHKESRFDVAEIGGMSQDLPHQARNLIKRMLGDPKVDMKNHWKLITILMGHNDFCSRVCYLPKPEKALYYHERNLIQTLRILRKYLPRTMVNIVGTINVNILKTFRPRPAQCVTLHRLESSCVFSGQFAHMQPRLDRLMKQWNKIQQSVAEREEFQSASDFTVNYQPFSAQLVLPTLANGDTDLGVASVDCFHLSQRGHALAANTYWNNMIDLVGNKSELVLSEFERFNCPLVDKPFLATLKNSVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZE5</accession>
    <name>A0A084VZE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001736-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011132</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="ATLV01018748">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZE5"/>
    <dbReference type="STRING" id="74873.A0A084VZE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011132-RA">
        <property type="protein sequence ID" value="ASIC011132-PA"/>
        <property type="gene ID" value="ASIC011132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011132"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011940"/>
    <dbReference type="OMA" id="EIGFPWS"/>
    <dbReference type="OrthoDB" id="437693at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="385" mass="43143" checksum="5E8CA19CA4DBE66F" modified="2014-10-29" version="1">MCLRVSPNATDCSMDSSSEEELEPEQPGIGGGRSSVVPVNRDRIPIVYRPEYGVRFCGLQKLHPFDAAKGGNIYRLLKANGLVQNDDDIYAPNEITVEELLDVHTKRYIESLKWSLNVARIAEIPPLIFVPNCFVQRSYLRPMRYQTGGSILAARAALESGLGWAINLGGGFHHCSADRGGGFCPYADITLTVRMLQGSGKGVERILIVDLDAHQGNGYERDLMDDAGVFIMDMYNYHIYPRDHPAKLAIRRAVELKPHTDDEEYLRKLRKWVTHAVAQKMLPYIEPPLFLYAIYRCLHQSLVEFEPNFIIYNAGTDVLKGDPLGLLDITPEGVIERDEIVFRAAMERSIPLVMLLSGGYLRSSARVIANSIINLRDKALLPTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0F0</accession>
    <name>A0A084W0F0_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">CMP-N-acetylneuraminic acid synthetase</fullName>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KFB43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11563" checksum="DED5B0948156F56F" modified="2014-10-29" version="1">MSELNDMKISKHLETNNMFLRAVDRAAPAPMQKNTCGDARPSVLMCNGANPCNIVPGSTVHPVGRQATIMMSSSAKGQLFSWRSGTHAHKCTATRAPCSKDAHAPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0S8</accession>
    <name>A0A084W0S8_ANOSI</name>
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            <fullName evidence="4">AGAP006013-PA-like protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">ZHAS_00011666</name>
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    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084W0S8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011666-RA">
        <property type="protein sequence ID" value="ASIC011666-PA"/>
        <property type="gene ID" value="ASIC011666"/>
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    <dbReference type="OMA" id="HGHDGSY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="17"/>
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        </location>
    </feature>
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        <location>
            <begin position="120"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="15812" checksum="3DD4780B133412D0" modified="2014-10-29" version="1">MKMFVALFAVIAVASAIGDYHQAPAKHIPIVHSESYHGHDGSYKFGYESANGIAAQEQGFVKNGGSKDHEVQVAHGSFSYTDPHGHPVAVSYVADENGFQAKGAHLPTPPPLPKELVDAYAKAASQPQHHEEPQHYAPQPSYKHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1G4</accession>
    <name>A0A084W1G4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011940</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1G4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011940-RA">
        <property type="protein sequence ID" value="ASIC011940-PA"/>
        <property type="gene ID" value="ASIC011940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011940"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6430" checksum="10E8A0F619D5CC18" modified="2014-10-29" version="1">MRILINNHLHHPGWHGKFEPVEKPKKTGISELYFPLPAACLLKPLAANNRRKGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Z5</accession>
    <name>A0A084W2Z5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012473</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Z5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012473-RA">
        <property type="protein sequence ID" value="ASIC012473-PA"/>
        <property type="gene ID" value="ASIC012473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012473"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9579" checksum="BCEE3CED2D3711A4" modified="2014-10-29" version="1">MPFASATSRKPDPKPLLPDVGERETSPGGRGKSLENDVPAHAYCVGQKAELGQADSVNGGSHRTSPYIVEPMNGARFTEPKTLPGSGRCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4P6</accession>
    <name>A0A084W4P6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013151</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W4P6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013151-RA">
        <property type="protein sequence ID" value="ASIC013151-PA"/>
        <property type="gene ID" value="ASIC013151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013151"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011723"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="433"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="9">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="8">
        <location>
            <begin position="879"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1339"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1383"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1502"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1569"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1592"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1622" mass="183784" checksum="2CB57C2322D14980" modified="2014-10-29" version="1">MFNADIWKSWERSGKSEFLKQCKAIVKDDPQQSPLFAKNERKSGISRAIYELISRGIHGQLKKDSVLQMLGEVSSLHSDIPSILLDVFGIFDAETATSTGDAPPSEERSTFCYIVKETERFVSEKLLKERLEIDTLQDVGTIKNRSFYTRFIKVKTKLYYKQRRFNLFREESEGYAKLITELNQEFNQETITVTDILEIIKSLIGCFNLDPNRVLDIILESFEARPEQDRIFIPLLQSYINDGNIICEVLGYKYRYFADVNTPSSLFKVTALLLQHGVIKLDDIYSWLNPTDKSIQADWEAEMHQAKEYVRKLNIILTNKDKEPEQEPEFETAPEKYALNQKWGLCEALLLIGDWNTAHQLLRKLPDQSVMVHEPIARALCRLLHIIIEPVYRLKCALPANIKGRAISSYGALSKLAPPPVTALTKLRLHAFPMFTALGPSLHYDSVLLYKLLRLMRVILTDMNVDPMNPPAPGTSADQEQLYYDILSLLDSSVLPALAYMDCNCCVAEEIWSIVKLYPYQYRYSLYARWKNDTFQLQPKLIQRRGTAQKQIKALMKRVSKENSKPVGRLIGKLSHCSPGFLFEYILLQIQIYDNLIAPVVDSLKYLTSLSYDVLGYCLIEALEQVDRNPMQNDGTSISLWLQSLANFCGAIYKKYNIELSGLLQYVANQLKSHKSLDLLILKEVVQKMAGIEAAEEMTNEQLQAMCGGELLRGEAGYFSQVRNTKKSSQRLKDALASNDLAVALCLLIAQQKHCVIYRETAQSHLKLVGKLYDQCQDTLVQFGTFLGSTYSVEEYVERLPTIHSMLQRYHIHSDVAFFLARPMFSHAINQKYDQLRKADTNAKKLSTSQKMSKYLEATAHVMNPVIESVRPLHPPKIWEDISPQFLVSFWSLSMYDLQVPVESYQREITKLRLLANAVMESKEQNASKNKKEQERYVALMDKLQDERKKQQEHVDKIMHRLTNEKDAWFLSRSAKSAKNETITQFLQLCLFPRCTFTALDAIYCAKFVHTIHNLKTANFSTLLCYDRIFCDITYSVTSCTENEATRYGRFLCAMLETVMRWHSDEATFNKECANYPGFVTKFRVSNQYSEAIDHVNYENYRHVCHKWHYKITKAMVFCLDSKDYMQIRNSLIILMRILPHFPVLAKLSQIIEKKVEKVREEEKNQRQDLFVLASSYIGQLKARAAQMMLESDFHQVTEKPFKATTTSSGASGSSAGATVVVQDSLQDSKVSMNGADVKGGQSTRQGSSSMGNGTTTNTSSTGGNSSSTSSSAMAAGGNGTSNGNLGGSSDHHRGGGHSNTIDLIKKEPSSSSSSSGSRDNNPGGGSSASMRESSVSLGREKSSKEIKREERAREKEREREEAAAAAILADRKREKEKRRDKRDHYDHERESRASERDLQQRDRSERDLSSVSNSSNEQQHGSSSIRRSQDPPEHDRDMKRRKVEGSSSSKSKHDDGSNSASQQLVSESKKERSSKTKEKRDKTDEEKELRKERKLGRKRQDRNPEESLLTDKRLRREEEKASKLLSHQNGDNDGDLLAAPLSTSSSSSHREKHHSHHHLKEKSPSYGSGAGGGGGGGSGGGGSGGSSGSLLRDHRERSHDRGLDRGEKQYFTKTSRTRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4S4</accession>
    <name>A0A084W4S4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Urotensin-2 receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013053</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020380">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4S4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013053-RA">
        <property type="protein sequence ID" value="ASIC013053-PA"/>
        <property type="gene ID" value="ASIC013053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013053"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="127" mass="14085" checksum="5069DDEFE5D45A1B" modified="2014-10-29" version="1">MASGRGSLLSVGLRQVFDAHCYHYAFFFRLACPNVTTNYANFTVTLVWFDNFSYHPALLWVAASFTAVARFVETELAPVSTGEGSLGVPSPSAKSSKAGIIYEEEKRNHKCEKVHFTSLTTPEQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5F3</accession>
    <name>A0A084W5F3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013382</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020615">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5F3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013382-RA">
        <property type="protein sequence ID" value="ASIC013382-PA"/>
        <property type="gene ID" value="ASIC013382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013382"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011778"/>
    <dbReference type="OMA" id="WEFWDAY"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="293" mass="31543" checksum="5BE1B16A74FEDB04" modified="2014-10-29" version="1">MFRLPTVLRVAAARQVAASRGYAKDVRFGAEVRALMLQGVDVLADAVAVTMGPKGRNVILEQSWGSPKITKDGVTVAKGIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPIEIRRGVMLAVDTVKDHLKTLSRKVNTPEEIAQVATISANGDRAIGDLISEAMKRVGKEGVITVKDGKTLNDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALVLFSEKKISTVQSIIPALELANQQRKPLVIIAEDVDGEALSTLXXXXXXXGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5H5</accession>
    <name>A0A084W5H5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001637-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020641">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5H5"/>
    <dbReference type="STRING" id="74873.A0A084W5H5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013407-RA">
        <property type="protein sequence ID" value="ASIC013407-PA"/>
        <property type="gene ID" value="ASIC013407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013407"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020695"/>
    <dbReference type="OMA" id="MMCAIEN"/>
    <dbReference type="OrthoDB" id="8193455at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784553" evidence="2">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="21747" checksum="A21D209377563F39" modified="2014-10-29" version="1">MGPLKQMTHCGSISALFAVLIALFGVSSSALTTFGKTNTNQQAAPTPPPVVAKSCSNHGDCSTIQNTSCVIDPTDDRMRCLCGDFKAPVNGLCTAKFKGLRHLCADTLQCDYGMMCAIENGTKPTTTLVTSKTFLTSSMLNSNGNGTYKVCLCDEEADFFENKHERHCSGTVMLVTSGMLIPLVLLLLGTTIASQPVNHWSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5W4</accession>
    <name>A0A084W5W4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ring canal kelch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013598</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5W4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013598-RA">
        <property type="protein sequence ID" value="ASIC013598-PA"/>
        <property type="gene ID" value="ASIC013598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013598"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023124"/>
    <dbReference type="OMA" id="DMVRYQS"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18445">
        <property type="entry name" value="BACK_KLHL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18235">
        <property type="entry name" value="BTB_POZ_KLHL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000002">
        <property type="entry name" value="Kelch-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="767"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1347"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1453" mass="155423" checksum="2936BB7275891984" modified="2014-10-29" version="1">MSSLGNGNQQNNMNSNTGSSQNSAAEGTMERGSCILVRYASQNSLDESSQKQIPRTNGREKTTGAYRNNIHTQRSFEAMNMMREQNLLCDVVLVADGIEIPAHKMVLASCSPYFYAMFTGFEESRQDRITLQGVDPRALQLLIEYVYTAVVEVTEENVQILLTAANLLQLTDVRDACCDYLQTQLDPSNCLGIRDFADIHGCIDLLNYAETYIEQHFSEVVQFDEFLNLTSDQVVHLIRSDRLSVPTEEKVYECVITWIQYDVDGRQHNLAELMGHVRLPLLSQDYLVQRVEKEHLLKDDLQCKDYIIEALKYHLLKGEQKTSFKTPRTIPRQPVGLPKVLLVIGGQAPKAIRSVECYDLREEKWYQVAEMPTRRCRAGLAVLGDKVYAVGGFNGSLRVKTVDVYDPVLDQWTTSQSMEARRSTLGVAVLNSCIYAVGGFDGSTGLSSAEMYDPKRQEWRMIAAMSTRRSSVGVGVVNGLLYAVGGYDGASRQCLASVERYNPATDTWTQIAEMSARRSGAGVGVLDNILYAVGGHDGPLVRKSVEAYDPVTNKWRPVGFMTFCRRNAGVVAHNGMLYVVGGDDGLSNLASVEVYSPETDSWRILPSSMSIGRSYAGNVPSEASGQPSAAGGNDDENSQAEGLNEGPGGNNGNQAHGNNVHYENIYESIEQFAPMNGGAAGGGNVVAPVGVPAVSNQQPMGAVSNPQPQPGPSGLSGPAHRTINGAGGGSSGGGPMPPPPPSMLHSMQQLYHPMAYRNELYDRTAGYDVPRGRTYQNQPGPSGARYANLHLDLNRPPRYPTGSLNPQQQQQQQRTPRKRSFDDTESAYQYYRYQNQANGSAKYDNLYERVREEPAYQNTGSFAPAASSAPNRSGLFGRFDVIGHGVGRIERHLSSSCGNIDHYSLGGHYAVLGHSHLGTMGHIRLSQSNGPAGTGGSTGCGGNNANSYANAPNQPNHAASKDSSSAVNVKSFFSCLGGENSQSMNNLNKPGSSSTNGSTSGGSSMLNGAGEGTGTGGSGQGSSIIGGLASAAAVGSSGVSTNGAIPKSTGTIPKISKKLKQSQQCNESLPGPSSVGPLAPAGDFAAPGELGPCGSRVSKPSLQWLLVNKWLPLWVGQTPPDYKFIDFNFMFSRNCDGCASGGGSHPPQELVRYGTLEQQADYIPPAREYPTMTGSYPRVLRNTPQLARLREHEYENVPLNDPPPMTGPSTSAAGRSASLRTSASLATARRVRSDSPGRAGSLRRSTEEKRAPATSSGGDPFRTWSFNFENNTFRPARNALPAGGGAAVTPGAFGKSRDVRRITDGTFTARDLQPDGEKPGPSGLQFVGATGKPAPQETPKQADTSDGRLSSASTSSDSDNFAIESLAVESVADGQTPRQEEDEEEEGAVGGVESKGKERGSSASNDSLESLTYEPEPAEAPDRSLSEDEIEGGAAGGGEAAKPAAEAEEKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6E5</accession>
    <name>A0A084W6E5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006839-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6E5"/>
    <dbReference type="STRING" id="74873.A0A084W6E5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013766-RA">
        <property type="protein sequence ID" value="ASIC013766-PA"/>
        <property type="gene ID" value="ASIC013766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013766"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012469"/>
    <dbReference type="OMA" id="TSYAKVW"/>
    <dbReference type="OrthoDB" id="7738419at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784603" evidence="3">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013766-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="251" mass="28507" checksum="4E3E3C5CAA110BA5" modified="2014-10-29" version="1">MFLSVQFVSAIAILAATAVQSAPVEPAQYAFVTKHHHVPEKHHVLEQVHHVQAEPQLAVHYPVELLQEHEHHQFQQEPQLVLANDKYLGAAHEYQHHEAPATSYAEGNDYSSLYGGKHGSHLYDNYQYGQQEVGYAKKYDEYNAYPKYSFEYGVDDPHTGDHKKQWEFRDGDVVKGGYMLKEADGTTRVVEYTSDDHNGFNAVVKKFGHAHHPEPKQHNAYGYIGNYAGAYATGDYYSKGATSYAKVWKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6N8</accession>
    <name>A0A084W6N8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP009349-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00013844</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6N8"/>
    <dbReference type="STRING" id="74873.A0A084W6N8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013844-RA">
        <property type="protein sequence ID" value="ASIC013844-PA"/>
        <property type="gene ID" value="ASIC013844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013844"/>
    <dbReference type="OrthoDB" id="7476629at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB45882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="24427" checksum="3B81334EB3657352" modified="2014-10-29" version="1">MLPCKTRARCFHCQKTITCFRHGTSNCKRHLARKHPNFYNGKEYIKFNPHEEETLDDGDDDGGNYEPSINDDTSQNEEEYTITEMQFVDCPDPKKDALEKAGSSKQSNEMTRVVKRGHDQGAKEDHDDSRESKSEQVNESFLRDLMSETDLSLQGTLYATNVAMQLDKLGEYQRIVAEKLISDVIYNAKLESLCEDSMVVVRVGTFEHDAGEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W724</accession>
    <name>A0A084W724_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002652-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013988</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021094">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W724"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013988-RA">
        <property type="protein sequence ID" value="ASIC013988-PA"/>
        <property type="gene ID" value="ASIC013988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013988"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019896"/>
    <dbReference type="OMA" id="KRPVQMH"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="430" mass="48165" checksum="F3E1729F376D15EC" modified="2014-10-29" version="1">MDQTEEKLDVIIFGASGFTGKYTIFEGIKLLEGLRWGIAGRSRDKLRQVLGEIEKKADKDLSEVPIVTADLKDTDSLKRMAERCKVLINCCGPYRFYGEPVIKACIEAGTHHVDVSGEPQYMERMQLEYHQQAQERGIYIVSACGFDSIPADLGTVFLERQFDGVVNSVETYMKFSSKIPFKGGAVLHYGTWESAIYGLAHANELRGLRTQLYKTRLPNFQPRLKNRPVLHKSSIVDGWWSVPFPGSDRSVVMRSQRHFYDVEKKRPIQMKAYIAFESLLHVLGVALVAIIFSILSRFKFGRQLLLKFPKLFSFGFCSHEGPTEKAMENTEFAILFKGVGWDKEEKLLEPNDQYKSPPTKKIVTKVTGTNPGYGATCVSLILSATTILREADKMPGSGGVFPPGAAYAKTSLIEQLCKNGFTFEVVKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7E2</accession>
    <name>A0A084W7E2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 15">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00014212</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 15"/>
    <dbReference type="EMBL" id="ATLV01021228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W7E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014212-RA">
        <property type="protein sequence ID" value="ASIC014212-PA"/>
        <property type="gene ID" value="ASIC014212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014212"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008665"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000013">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="475"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="18">
        <location>
            <begin position="736"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1116"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1286"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1476"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1505"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1522" mass="170663" checksum="7016D59657F00950" modified="2014-10-29" version="1">MNPDSDPLGSVNGHFSDSQAAFAAQQNGAAAAAAAAGAVASPKIGGKSIEKIYQKKSQLEHILLRPDTYIGSVEMVKEQMWVYDKEGNKMVQKEITYVPGLYKIFDEILVNAADNKQRDPKMTTIKVEINQETNTISVWNNGHGIPVVMHKEEKMFVPTMIFGHLLTSSNYNDEEEKVTGGRNGYGAKLCNIFSTKFTVETASKQYKKCFKQTWGDNMSKASEPKIKEDFHGEDYTKITFSPDLSKFKMEKLDDDIVGLLSRRAYDVAASTRGVAVYLNGQRLPVKTFKDYIDLFLKDSTDDIGGSVKVCYESVNDRWEVAVAISERGFQQVSFVNSIATSKGGRHVDYVTDMIVKQLTEVLKKKNKGGVAIKPFQVKNHMWVFINCLIVNPTFDSQTKENMTLQSKSFGSKCNLSEKFINAVAKSGIVESVLQWAKFKAQTDLAKTSGSKKSKIKGIPKLEDANDAGTRNSLNCTLILTEGDSAKTLAVSGLGVVGRDTYGVFPLRGKLLNVREATHKQILENAEINNLIKILGLQYKKKYLTIEDQKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLQFLEEFITPIVKATKKNGTELSFFSLPEFEEWKAETPNAHTFNIKYYKGLGTSTSKEAKEYFQNMERHRILFRYEDTGDDDAILMAFSKKAVEQRKDWLTAHMEEVRHRKQVGLQERYLYTKSTKDITYKDFVNLELVLFSNSDNVRSIPCMLDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQSLCSTIVNLAQNYVGSNNINLLYPGGQFGTRLTGGKDSASPRYIFTMLSALTRCIFHPLDDPLLAYQYEDNQRIEPVWYLPIIPMLLVNGADGIGTGWSTRIPNHNPRDVIANIRRMLNGEEPKVLNPWYKNFRGLIESVGPQRFLIVGNVGLLDNQKIEISELPIGTWTQPYKENVLEPLLHGSEKQKAIIADYKEYNTDTTVRFVISFLPGEYAKLYAEEGGFHRVFKLTSAISTSTMNAFDDKSYLRRYNHANDIFMEFYKIRLEYYGKRRTYLLGMLQAEADSMSDKARFIMEKCNGTLVVENKKRKALIEELIKRGYRPDPIKEWKRRVNVDQEEEEGEAGEGGEEGEEVEDVKPGKAGSSSKAPVDPEKAFQRLTDVKKFDYLLGMSMWMLTDERKNEILKQRDQKLSELKALQAKTNESLWMDDLDALSKKLDEVEEKERLDAISTEKKLKAGASKGVSAGGRKVVKKTAIDDTKPSADAEAVRFKMTEEMLKKYEKAAATAAASKVKKEKKEPGENGEEDEFDALVAAGAEPGAEKPKPKPRVKKEPKEPKAPRAPRVKKEKGSPGEKGPAKRGRKKKVTTSDEEDAFNSDMSGDDLAPAVSVPTREKTGRRAAATKKVNYSLLDGGEDDEDDNFNRSDDELFDNNPEQRTSGTAAAADDSDVEVQESRPAAVVDVGDDSDSSPVKRRPGPLKKRALGPKAADAKPAPAKRGRKAADSGSDEKPKKVNFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7F4</accession>
    <name>A0A084W7F4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021241">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7F4"/>
    <dbReference type="STRING" id="74873.A0A084W7F4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014147-RA">
        <property type="protein sequence ID" value="ASIC014147-PA"/>
        <property type="gene ID" value="ASIC014147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014147"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784645" description="VM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17428" checksum="50B5D9F5F2AC2148" modified="2014-10-29" version="1">MNRFFTITLLSLGVALAAPPMYGHGGGYGGDLVEPGPAVVYTYPAVAPVVKCGHNLVVNCGAHHAGVPCHAASHHGHGNGAYGGHGTYGGHGAYGGHGAYGGHGGYRQQTPEMEDQGFVQLPARGRQSRPGKYPPFPTTMRPAPTTPSTVQQSTPSGYTKPTTNAPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Y5</accession>
    <name>A0A084W8Y5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative DNA binding helix-turn helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014711</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021532">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8Y5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014711-RA">
        <property type="protein sequence ID" value="ASIC014711-PA"/>
        <property type="gene ID" value="ASIC014711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014711"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7591" checksum="D98D8BB79DBD3012" modified="2014-10-29" version="1">MLQGVFDRRETQTGFRLEAQNRPNVDGAAPQSPARCPIITLNIFTSGADGHEGLAAIFADILLSPPPGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W919</accession>
    <name>A0A084W919_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003091-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W919"/>
    <dbReference type="STRING" id="74873.A0A084W919"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014710-RA">
        <property type="protein sequence ID" value="ASIC014710-PA"/>
        <property type="gene ID" value="ASIC014710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014710"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001388"/>
    <dbReference type="OMA" id="IYKFRIQ"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF32">
        <property type="entry name" value="EUCALYPTUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12395" checksum="EBD5F51F503D14F3" modified="2014-10-29" version="1">MTLKSDAVFERIAKRLQSIDPNNRQVQQIYKFRIQQNGTVVKSWVLDLKAVKLTESDGPAEATLTMEDDIMFALGTGAMPAKEALAQDKLDVEGQVELIFLLEPFIASLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9M4</accession>
    <name>A0A084W9M4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP005263-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00014928</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9M4"/>
    <dbReference type="STRING" id="74873.A0A084W9M4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014928-RA">
        <property type="protein sequence ID" value="ASIC014928-PA"/>
        <property type="gene ID" value="ASIC014928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014928"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005953"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023207"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000004">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="496"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="738"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="833"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="962"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118791" checksum="99DA3991AD76DF3B" modified="2014-10-29" version="1">MSNPPQYYGMPNGFPHSSNGQTLQQQQFSAIPPGNVNPSKGSTLPNGPPSGMIGGNQPPPHQAGSVKPVQPTNGPPMAGQPGYSAAPTSMPYSMSSQQYQQRIGNWPATNGNSATSSRTASPALGSAGMPPVSVSAAAPTPPASGVGVRNFPSVANSNGTNNNNNNHPPMASSQSQATPIVTPQSLQVAGGAARPTIGVGANNGYNLSPNNNWSGGNVAAPGGNLINTPPKSASGMSTPLNASTPTLTGPLLAGGQQQQSAAMQKLAGSIQDLNLNRPPTQQPIQPPFAQQHAPPTMSNGSSEQTHAQTNGTPMATSAPQPGMVRPTGNVLRSGFNRMWGNNTVDLLQNRHVLPTDRVRPPTIHLLNPNQEAANCNPDIFRCTLTKIPDSSSLLQKSRLPLGILIHPFRDLNNLPVISCNTIVRCRTCRTYINPFVFFTQESKKWKCNLCYRVNELPDEFQYDPLTKTYGDPSRRPEVKSSTIEFIAPSEYMLRPPQPAVYLFLLDVSSLAQQSGYLNTVCNTLLEHLENLPGDARTQVGFIAYNSAIHFYNIAEGYNQPHEVTVLDVEDVFLPYPDNLLVNLKECKELIKELLKQLPKRFEHTHDTHSALGAALQVALKLMTPSGGRVTVFQTCLPNIGPGALQSREDPNNRSSKEVAHLGPATDFYKRLALECSGHQIAVDLFLLNSQYCDLATISGISKFSGGCMHHIPLYNESKPQLVKTLRKSLERYLTRKIGFEAVMRVRCTRGLAIHTFHGNFFVRSTDLLSLPNVNPDAGFGMQITYEESLAELKSVCFQAALLYTSSKAERRIRVHTLCIPVTASLTEVMYSADVQCIVGLLSKMAVDRSLSSSLNDARDAFINATVDIFSAFKIAQNLPQNSGTIVAPENLALLPLYIQAILKHPAFRTGTSTRLDDRVFAMCEMKTLPLDQLMRYIYPDFYVLDCLFAPAGKGYVDEGQRPEPPRLQLSAEKLDSRSMFLLDCGAHMFIYIGSNVASSIVRDILGYNSVAEIPDFCIDLPCRETEASTTLINFLDALNEEKPYSAYVQVIRDTSQFRSMLVEKFVDDRSPNVLSYYEFLQHLRTQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9P0</accession>
    <name>A0A084W9P0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014946</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9P0"/>
    <dbReference type="STRING" id="74873.A0A084W9P0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014946-RA">
        <property type="protein sequence ID" value="ASIC014946-PA"/>
        <property type="gene ID" value="ASIC014946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014946"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009702"/>
    <dbReference type="OMA" id="LEYNHRI"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="16249" checksum="690A12BB3E7AC643" modified="2014-10-29" version="1">MALMLPLFNPDVPCLGAILGGLQPGKKIIIQGTVTDGRFNINLQLGPEVEPRDDTALHLSIRPSERRIVRNSYVDQCWQNEERSGGCPISVGEPFTLEIRVKDLHFSIRINDEKYCTFAHRLPIDMINFIHLGTGATIDSVMESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R9</accession>
    <name>A0A084W9R9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00014978</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9R9"/>
    <dbReference type="STRING" id="74873.A0A084W9R9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014978-RA">
        <property type="protein sequence ID" value="ASIC014978-PA"/>
        <property type="gene ID" value="ASIC014978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014978"/>
    <dbReference type="OMA" id="TMLMIVN"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014978-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="413" mass="46020" checksum="1D0C8BD347314BAD" modified="2014-10-29" version="1">MVLLSLRSVRALENIHAFLSRPMLRSEQDSVGNALVCIAVYTNHTMRTVTNIFIVNLAVADFFVILFCLPPTVVWDVTETWFMGKAMCKVVIYFQSKTKKYKSNYDLHPTDTKTTSSAYLTVSVTVSVLTLTFISIDRWYAICFPLRYKPRPERAWRSIALIWLIGFLAVRVLWRSDTIPGHRESRNQPCGSKFRREFKNALEKCRCLRNSHAYGGRVGGYDDRSLCHTATRLNVSPSTRSNYHLASQHTQQTSFNGSRHRHGRNSINHPGSLQPQISPISMEERLALNKTLDGETLQLTNRKNCTPLLVTNGAGNGNNNHSNSCIKTNGNGHGPETNGNQQRQSARQDRSSLHLKPHDGYLVPEAALGDGVADEGGVSENGVDGACREQSVPAPTTMLMIVNKSSNCKINGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA96</accession>
    <name>A0A084WA96_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005942-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015191</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA96"/>
    <dbReference type="STRING" id="74873.A0A084WA96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015191-RA">
        <property type="protein sequence ID" value="ASIC015191-PA"/>
        <property type="gene ID" value="ASIC015191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015191"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020701"/>
    <dbReference type="OMA" id="VNIWEAL"/>
    <dbReference type="OrthoDB" id="6409105at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784582" evidence="6">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015191-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="293" mass="32221" checksum="B63D98213A94D7D8" modified="2014-10-29" version="1">MDKCIWNVVILLLLEKLSFLSAQIVPNCDSTIGCLAFSTQAACTGPDEFWSPNATHGGCCPGCIQALPLGAVCNEPSTTTVSPEGAPSLPCAPGLVCGLGNVCRLNTVDCLSTYHVATDTIDWVPQCDSRGQYAPKQCRGDRLNGRCFCYSAEGKRIFGFSWRNQAQNMTCACSRRRADLEAEGRIDVTLHCTPDGNYEELQCDRGVCWCAEPQTGTQQPGTRAVPEDLWTLLPCYNETFHGVQYLRRCESIAFSQILQRRQFIIHGHTGVTFTNVICNYDGSHGRYVIEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAR9</accession>
    <name>A0A084WAR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Gag-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015347</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAR9"/>
    <dbReference type="STRING" id="74873.A0A084WAR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015347-RA">
        <property type="protein sequence ID" value="ASIC015347-PA"/>
        <property type="gene ID" value="ASIC015347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015347"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002711"/>
    <dbReference type="OrthoDB" id="7744881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015347-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="433" mass="48863" checksum="177A38638E6528F2" modified="2014-10-29" version="1">MVPATAKVLVPKTGDQPLSLEMENEILASEPSVEPVSRLQVSALADSVAALTNQCEQMMRQIKILVEQMQEMQKTSMSSVQREAKRQEKQWRSQQQQQQFNRGVTLDELYRQREEQRRLENDSMRLLHEQQIRELDVRQEQQRVTDMLELRRQQQVVPVVQSNDAWSVVASCGTRKLPSQQQPLPTAKQSSSQQPRPAPANIIIGGPAPKRKRRPRKKKPRLDAVKVTALNEATYKDLYMAVRGNWELDDAFERPRRTGDKELTLYLNKAVDSGAALTQVSQAVGQTASAKLLTEMTTVEMKGVDMLVTVAEVAEAVEMSTGIQVAVTSILMRTRGDGLQVARMRVARRASKAVLCKVLQIEYTRVRMQELPPVPIESQRCFRCKERGHHSRDCKGVDRPDRCFNCGSNEHFAANCIVPTRCMACLGPHVVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB11</accession>
    <name>A0A084WB11_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015653-RA">
        <property type="protein sequence ID" value="ASIC015653-PA"/>
        <property type="gene ID" value="ASIC015653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015653"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9187" checksum="A3F2B17AB793A133" modified="2014-10-29" version="1">MFEVEHKHLHKQQQTTTRVVAPTSPENGRSLDLLLSRGWSIDDVVVCLKIIVGMTAHDSVVLRSSPICGGIAVSMSPLAAVAPLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB76</accession>
    <name>A0A084WB76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glucocorticoid receptor DNA binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015420</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022316">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015420-RA">
        <property type="protein sequence ID" value="ASIC015420-PA"/>
        <property type="gene ID" value="ASIC015420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015420"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="17999" checksum="B436BFEBF69BF6E0" modified="2014-10-29" version="1">MGDVGELLLFTFIRLDSGRTVDIEPVSPSSPAIPARHPVGEGLCRLHDDDDDDHDGDAPECVVLVEIHRCKYPLRPLLDHLDRGVSVVCNLMGENMHALVHGPQFDAPPTSSNIHFETYTAWHKPVVSCVVVVVVVRVCCCASGRAFRGVYAGHNSSTGLTNFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCL6</accession>
    <name>A0A084WCL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008010-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016012</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525336">
        <property type="protein sequence ID" value="KFB47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016012-RA">
        <property type="protein sequence ID" value="ASIC016012-PA"/>
        <property type="gene ID" value="ASIC016012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016012"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016515"/>
    <dbReference type="OMA" id="PCYCSIY"/>
    <dbReference type="OrthoDB" id="7776691at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784864" evidence="2">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016012-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="36227" checksum="52FFCB98A0EDB2DD" modified="2014-10-29" version="1">MGVWASSSLLGVMMLSLVLSTVLAVTPTGKVDFTEADDLLNDDADGAGGFVSVYKNFPKIQVTVDTLKLKRVSQPETKSDESSSGSSGSSVSESIERPAVGVRTDITIEISEETANDTRTPASDREGKRDRDGPGSANKPAGGGKKDAGADGEGGDNASIPVFKGTAGVTYKPKPTATRGPHGSRPGVTLSQRPTGNNFYGSGGDDRNRISGEYDGGWSGRYPHTVTAVWTTERPYLRRADYDFGGQHQPTYYKGYIPYNVGHHSQPADGHHHHSGDWKPCYCSIYQPWAARAPTNPVLPSGPHQPPPPSPPRHKVDNKVDVPVHSQQRQHYRSIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD52</accession>
    <name>A0A084WD52_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein decapentaplegic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016210</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022936">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022937">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD52"/>
    <dbReference type="STRING" id="74873.A0A084WD52"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016210-RA">
        <property type="protein sequence ID" value="ASIC016210-PA"/>
        <property type="gene ID" value="ASIC016210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016210"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008863"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022175"/>
    <dbReference type="OMA" id="DERHDSW"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13760">
        <property type="entry name" value="TGF_beta_BMP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.970:FF:000018">
        <property type="entry name" value="Decapentaplegic, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784572" description="Protein decapentaplegic" evidence="13">
        <location>
            <begin position="24"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="14">
        <location>
            <begin position="494"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016210-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="612" mass="68758" checksum="B5C73933F3237078" modified="2014-10-29" version="1">MHAWLHVLAVLAILPSLIQVAGTDGTGTTALISVFSGGAVEGGESPRFSSSNQPGPTSEAASSVASEKLASDTASRDIQVNPTVQSGGVNSDISEYREYVERMPDPVEEPVEEPVEPAPDSVDSENDIGDGSYGYGSASSDSSASKPDPKTLVEIEKNLLSLFGFPNRPKIDRSKVVIPEAMKQLYAQIMGHDLVDSVSVPKEGLNTRNANTVRSFTHEESNIDERFKHHHRFRLLFNVSSIPRGEKLRAAELTLTRDGIPAALPSTTYQVLVYDIVRPGIKGKRTPTFLLVDSRTLRINETGTASFDVMPAVERWLRQPRKNHGLFVQVTSRAQRGHRRQRRSVQTVPDHEHVRLRRSVDERHDSWVLVYDIVRPGIKGKRTPTFLLVDSRTLRINETGTASFDVMPAVERWLRQPRKNHGLFVQVTSRAQRGHRRQRRSVQTVPDHEHVRLRRSVDERHDSWVQKQPLLFTYTDDGRHKQRPIRDAISSANRARRASAKRSSRRKNELCQRKPLYVDFSDVGWNDWIVAPPGYEAYFCQGDCRFPIADHLNTTNHAIVQTLVNSYNPTLAPKACCVPTQLSSISMLYLNEQNKVVLKNYQDMTVVGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFJ2</accession>
    <name>A0A084WFJ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016991</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016991-RA">
        <property type="protein sequence ID" value="ASIC016991-PA"/>
        <property type="gene ID" value="ASIC016991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016991"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="15413" checksum="74BFA0BA1D5B3043" modified="2014-10-29" version="1">MFSSDETPFFGPKRNTTPRCVGRKGTQDIGTITITIIIIIVLEILKRTGLIMIMNSDAESTPVELRGSLSLSLEWFGPSGGQLSRSSSAAAAARECPQTRLQCCPFPKPASSGSGGAVTGQTEPLLNDGRTNGAGCFRNLYDMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGG2</accession>
    <name>A0A084WGG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Lysozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017422</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017422-RA">
        <property type="protein sequence ID" value="ASIC017422-PA"/>
        <property type="gene ID" value="ASIC017422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017422"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="199" mass="22753" checksum="3100432D87E3EAE6" modified="2014-10-29" version="1">MSVIASAEDEIKNPGRQDDGMGKLVRVSVFSRPGWQSNGRKVYGRAVCSRETRFVISPLHIAGEKRELQRIAPVTWIIFHSHEIALVAYCFTIAYLGRDKLCREKALKQSAFKPAGKAILATDTCLDRHQREANVIYILCPSAFSYTAWPQACCFYYELVCSTSTRRSRRHLEPAFTRCLNFNFNFQCHLRSTPRQSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGT1</accession>
    <name>A0A084WGT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017528</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023714">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017528-RA">
        <property type="protein sequence ID" value="ASIC017528-PA"/>
        <property type="gene ID" value="ASIC017528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017528"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9062" checksum="364A290F5E7E669C" modified="2014-10-29" version="1">MHWGFCSQALTFAEKPQPSGIREATLPVAQELALPEFGGSDGTLDKLPGPVARFGSLFTVSCRARCLVPSAGKGELGCTTPSHCGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHM0</accession>
    <name>A0A084WHM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018348</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018348-RA">
        <property type="protein sequence ID" value="ASIC018348-PA"/>
        <property type="gene ID" value="ASIC018348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018348"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10647" checksum="8ADD5EBF661F2E31" modified="2014-10-29" version="1">MTLKLKCGRLWDYRPSPKSIKNNETRNPGPKADDNGWRLPEPSGWRQQPSIGFGGVSGWVNRGRRKEGRKEDRRNAKNRDILFIVPFSRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHZ9</accession>
    <name>A0A084WHZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP012259-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF4211 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017865-RA">
        <property type="protein sequence ID" value="ASIC017865-PA"/>
        <property type="gene ID" value="ASIC017865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017865"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015501"/>
    <dbReference type="OMA" id="ECATRFE"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="313"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="537" mass="61042" checksum="5A6BA5DCD488D192" modified="2014-10-29" version="1">MAFPCIIFGRCSSVVSQDRPGCYFCYVLSEHSPSELLLMLLRSFARSGTDPLVVPQRRQTTNRKAKAKAVELQQQILGGSKATGRALDEVEEPAEFANDSDSDPAWTPTEDKHHLSQIHQNQHTAQSHMLHPQPSMQRQTQSVAGVQQQHQHQQQQMGNHQPQPNIVYPSQSPTNNNMPTQYGIQQQPAYSAPASNQNTQPAVPSTESGEDFQTGDFVVIRSELMQDYPAIWRVDGKTLLQKYEAFDDQTGKMLHRNVSTYAAWNAESKKLYVKIPVRYRVYNQMETVVEFMRSEMVLGSGAADGSFDHQQFRETAMADTKIYQDVFEVYIQTLISQALDSNFLKEILQEQDEYFLSRVKTIDNLTEDRRQRLIQITPWSHHIISSLATFPAYDIMNELGHQHHHQQPVCAACHQPGIAVRIVLQGQTYNAATLGASTSANNSAQYEKNLQLCRGCSSRFELLHKICHQKYIMFVECAKRVNQQISNDSSKGPTVILNDLLADENWLSMLFKEVRSIWAEIELLERQYRFQMGGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI24</accession>
    <name>A0A084WI24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017894</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017894-RA">
        <property type="protein sequence ID" value="ASIC017894-PA"/>
        <property type="gene ID" value="ASIC017894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017894"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9004" checksum="03FC14E077526720" modified="2014-10-29" version="1">MLNFVMAPGRNTGPSVTVTIPGEFTVMLLPKDKQAKKDGSHPARCPSGCFESEALMFPVVDGGDAVGVHRWGFNVDVVIGCEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WID8</accession>
    <name>A0A084WID8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00018021</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01023929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WID8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018021-RA">
        <property type="protein sequence ID" value="ASIC018021-PA"/>
        <property type="gene ID" value="ASIC018021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018021"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019167"/>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="6778822at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000722">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="223"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="516"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="522"/>
            <end position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1609" mass="179092" checksum="09B72344FA10072F" modified="2014-10-29" version="1">MAQRETFRERQENELEVIKSIFHDEVEDLRPKEGKWKPLELQLHLTPQKGSAKEAYVKADLHIICNPKYPKYPPKVELKNAVGLSDSLVRELADQLQRQADELKGEVMIYELANTVQTFLHQHNVPPKGSFYDEMLANQQKQALARQNTLQAEENLKRQAIQDELQRRKKELARTRRESRQSLNDSSPLHRLHSSSSTENSDGVYCLEHRRSELLYFRDGRKVLRGACLGHSQRGCITYSGIDQQSGELIYLTEWTLHYDGESLESKLIRARPVDTVVTDIERLVESLTPLRHKHLIAYEGVLCRIGKEALTVFVAQEFILGTSLFSISGSLGWSVEGASMVAKGALEALIYLHNNGVSHDNLSDSTMFMDNAGMVRVADFRLIPYIQELGDGQQLHQTIRSPDLPALGSLIEALLAPHSEMKDFIEKCKSERTISATDLLDHPFLRTILLHTEHHQGAVGQITTVGAQKTHHLERSQQTGAQQQQQQQQPPSPYMPLIMNNSLTAAGKSRIQMEFEILSYLGKGAYGDVLKVRNMLDNREYAIKRIRLPARSKQFYKKMTREVELLSRLNHENVVRYYNSWVEAISAAEMVHVDTVGGADVATLSSCDWSVGGGTTPIQGKRGRRGQKPRPPARRNNASYAEEESSGGIEFVGSNGEVASYSNFNDGTSVAENGGANGKPTPTSAPPEVLYMYIQMEFCEKSTLRTAIDADLYQDVDRVWRLFREIVEGLSHIHQQGMIHRDLKPVNIFLDSRDQVKIGDFGLATTSILALQNQSQPNGQLVQLAIGNQKAAGKSSDMGCSLTGKVGTALYVAPELTGNASRSTYNQKVDLYSLGIILFEMSSPPLNTGMERVKTLMDLRADPVRLPDSLLADGRYSRLVQVIRWLLNHDPHKRPTAEELLSSELVPRTRLEAEEIQDVVRHILSNPQSRHYKHLIARCFAQESDPICELSYHFDMVPMVPILPRFDYVKEKVIALFRKHGAIEVVTPLLTPYTKQHAARSNTVKLMTHSGSVVTLPDDLRLPFLRHVALNGIRNIRRYSVGRVYREKKVFNFHPKQVYECAFDIVTPSRGYLITDAELLAIAMDVMRELNLLQNRNVFFRLNHIGLLRALLIHCNVPVDKYRELFEIVAEFLDDKISKFQLCSLINAQLGGGGGGASNGGGGGGGSTKVNVGYLCDAVQLELASVGQLNGSILKTIIRGKGEAASMAKVAVRELETVVTLAQNMGVQCPLNVCPGLPVNYERAKTGGIVWQLLGELKPKRKNPLTTIAVGGRYDGKLVEFQKSGINNGLQVPKVELSGAGFSFLLDKLVNAIAPTAGYEPVQVMICVTGSRPQLKEVAHILRPLWSNGIKTAVVETSATAVDDLGKEAGANVVVLLGDGGELRVRSWDNDRFQERHVTRPDLIAYVMRTFRRPDTAPNEVASQALQNVTLGSASSVSSFSTSFTTSASSSSVKLSSTIGGAANASQSGSGSPPIDLVFLTNEKINTNKKRRFEHQVEHKLSPVLSKFHRKEKVTLIMVDLPSSPLRGLVGLIDPLECGFHEEDDDDSTAASNNERLELQNLCERYPKYKRQLMEIYSEIVDLFSQDKRTTPIVGVYSVVDTFCRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJA7</accession>
    <name>A0A084WJA7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ferredoxin:oxidoreductase FAD/NAD(P)-binding:molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024005">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJA7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018451-RA">
        <property type="protein sequence ID" value="ASIC018451-PA"/>
        <property type="gene ID" value="ASIC018451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018451"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9227" checksum="B2764E5B9DF0E3DD" modified="2014-10-29" version="1">MSESAPRYTQKTTPSGDMTVSEAPSRSWPADSLLEILPIDTASATLDEGALKTLISGMLRDWRGEWKNIHSCTFQAEHHHTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJZ8</accession>
    <name>A0A084WJZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006116-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018933</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJZ8"/>
    <dbReference type="STRING" id="74873.A0A084WJZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018933-RA">
        <property type="protein sequence ID" value="ASIC018933-PA"/>
        <property type="gene ID" value="ASIC018933"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018933"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014612"/>
    <dbReference type="OMA" id="HMCFYAY"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13354">
        <property type="entry name" value="PH-GRAM2_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000013">
        <property type="entry name" value="Putative TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000049">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036017">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="469"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="847"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018933-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139490" checksum="C4F68800F6FAFC77" modified="2014-10-29" version="1">MWIPPRECSMPFALWVNETTKATSRYFFLQHRKGHGSVRGFSSMLVGTLDNVLDTKPSPYRILHYQPSTGLCFEIAADITLEAIMLDWDWLAKNLFRVISDMESDSMEEAEITNFTICKIQSLLAHRTQPSEEQNDPTSFQLAVNKFREKFRMPEDEKLVNYYYCSYFRKIPRQGQLYLSLNHLCFYSYILGSESKLCFRYNELTEIKKSGNTITIRAGQQSTKEYTFMFLLSPSEVYQLIEQLSKLTMQKMIQDPDRPLVDHDPVILKKMEKNVSQKTLLLRDLTARQQSDEYRIHFRVPKTEILDGRIKASLWAPYRKKHIEGVLYLSQNYLCFKSDVAAMVSLVIPLSKIVSVEKNEDPHNRFSNRIIITTSDGNIFVLQHILDREFLINKISELLSKTVAPARVPDDLDWVKQEPLMHLFKDPNNRAFDELQAEKMKRWEEHFSLYGRGISMFRTTDTINLVIEGIPDHLRREVWLIFSGAIHMKMTHPNLYKELVTKAKDQHPVSFEEIERDLHRSLPEHPAFQTSIGITALRRVLQAYALRNPEIGYCQAMNIVTSVFLIYCDEEDAFWILSCLCESLLPDYYNDRVVGAQIDQGLLDELIASHLPNLHVKLAELGMIRMISLSWFLTIFLSVMPYESALHIIDCFLCDGAKVIFIIALKILEWNQEKLLNCNDDGEAMQLLSNFLSGIFNDEVQRIKIEDKEKTQVKSQSVQTLIYEAYLKFGKAITSQKIEELRNKHRRLTVHQLEKDLENSVIKNYKDNGYFDCDELRMLLCYTKDEKISLKNRSRPTSVSGGEPVYDVTVLNDAKKRFRDNRYDCFRVDYETFRKLFVDLTPWGHCQNIDISEKLFRLMDKQSCGYLEFKQLIFAIGIICSKRATEKLKLLYILHLPPLLTTQELETSSISESRDSDTEVATEAESFFSENPLDTLKSLPSPIDISLEATSDVENLSLSHFNATPNLSMDESKSVGEGETSSVFYVDLPSTSGTLVVAGTSGTAASNAAVNANLGEAESIGSRSDISDLGFHRYGSLDESASRRTGTEARSISGLRIFLDDPDSNFTYKTIPNMTQKNFISLWTTLLEILNKDRKVTDQEVQTSYKTLIALGEDAAFTRRDDSNDSFTQLAYPGVEAGGDGFDPNGNPSSSSSERTPRHRSASGGGGGGFASNAPADVPWEISLTQFVATAMAVGIIEEQFSLPFSISTRVETLQKNRRKCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK87</accession>
    <name>A0A084WK87_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP007134-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018663</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK87"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018663-RA">
        <property type="protein sequence ID" value="ASIC018663-PA"/>
        <property type="gene ID" value="ASIC018663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018663"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5744" checksum="F009D4E203126A66" modified="2014-10-29" version="1">MSVADNFTDFYSGSSFVFRMAVDEYNSERNWTGLIDRYWLIVEELIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKN1</accession>
    <name>A0A084WKN1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00018824</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="16"/>
    <dbReference type="EMBL" id="ATLV01024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKN1"/>
    <dbReference type="STRING" id="74873.A0A084WKN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018824-RA">
        <property type="protein sequence ID" value="ASIC018824-PA"/>
        <property type="gene ID" value="ASIC018824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018824"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012025"/>
    <dbReference type="OMA" id="GIVNEQP"/>
    <dbReference type="OrthoDB" id="669224at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005024">
        <property type="term" value="F:transforming growth factor beta receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14054">
        <property type="entry name" value="STKc_BMPR2_AMHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23533">
        <property type="entry name" value="TFP_LU_ECD_BMPR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000659">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF100">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="268"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="633"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB50775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="970" mass="107801" checksum="2D9F62E7B3C85FB7" modified="2014-10-29" version="1">MQIPCQHETDRNGKRSTGMANSITSWKQRGQDRNLKGVWWLRLGFVLISTSSLIPTGQATPIQSRCLQFGTTSTTNTQQQNGQESADDYNYNYDDQPEPSDEPVFEKNISTIVTCTRSAPFCYTLWTYDVAQNVTKVVVQGCWGSSDEQESCSSTNCVSTTETPTKHFFCCCTGDSCNGNYSYVPPPTTADGLSVREDTDSITPFAPYTSIWSSPTVYICFAIVAIMLMASVAIFSCRQLPKKGVDELEKMEPSGPGYSANLYNVDNLKLVAMIGQGKYGTVWKGIVNEQPVAVKIFAGQHRQYFLNERDIYTVPLMESPALLTYFGSDERRTMDDRIEYLLVLSLAPLGCLQDWLTDNRVPFDTFCRMGRSIANGLAHLHTEIRKGDLVKPCICHRDLNSRNILVKADLTCCIGDLGFALKTFGARYEYRGEITLAETKSINEVGTVRYMAPEVLEGAVNLRDCESALKQIDVYTLALVLWELANRCEDFFPEDIPVPEYRAPYEEYVGSNPSFEQMQVLVSRNKARPTFPLHFGQGLVTQIVRDTCEDCWDHDAEARLTAMCVQERLQEISQINPHARTVPSKGCSDDGEGEGGIGKNQLYSLESDGMVNVTSLERYNSPDGTIMAFMTPPNQQIIPLPPGGGYRDDTTGSYKYGQLASMGNISSTNTSQHHPSSQSDEDELLHGTGRKGQQPLMQKDTEMKRSGKALSSVKVMLQKTFHKHQNITNNIIQHPYDVQQDSYDGDDRSNLVVVVESTDGCPQQPQTTPSQEEIIMNHHNSQQCAMERPTNLDLALGKYESNLLLHEPRTVVNGSRAEADDGRGQYAKMLAEADFASQSFAILDEGDGGDEAADRQGLVSDQKLRIVVSKSANAMHQSRAPRMDATASHSPLLVDDRSLKRQRSLEVFHEVFGPKGSIERLRNPSQRVKTPGDVPPSVRKVRASKTLSLYDDRMMMTTSVGSGNRLANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLN2</accession>
    <name>A0A084WLN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019187</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019187-RA">
        <property type="protein sequence ID" value="ASIC019187-PA"/>
        <property type="gene ID" value="ASIC019187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019187"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019187-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="195" mass="21612" checksum="6F98DAEF81051B08" modified="2014-10-29" version="1">MSRTARESVPFETSVSPNARKNKFALLPIIISCRFGVTKMSVADVVPCVSARWPSLIFDVVGERGFIEAVRVSEAEGTEAAKGGRQSEKQSKRYGQSSFRRGRRRRPPSIEYSPVSRFHYLPSTQPISIIPDRRLAGFDLWRSTVRVSVSGQKNPQSAGDDHREGSEMVTRRVKCEPRQGASTVDGVDADDSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNI1</accession>
    <name>A0A084WNI1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dehydrogenase/reductase SDR family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00019954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNI1"/>
    <dbReference type="STRING" id="74873.A0A084WNI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019954-RA">
        <property type="protein sequence ID" value="ASIC019954-PA"/>
        <property type="gene ID" value="ASIC019954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019954"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017587"/>
    <dbReference type="OMA" id="TWAWWLT"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36050" checksum="0BD174114B4944A6" modified="2014-10-29" version="1">MAFFVYFVTISFFAYHLIRLILWAALDSDIELFVLSKLGKPISSLRGKVVWITGASSGIGRDLAIALARNGVRLCISARNISELLKVKQACIAQSNGSLGPNDVYVLEMDMLHVNHHNDYFNMVLDHFKTVDVLVNNAGRSQRAAWGAINIKVDRELFELDVFAVVNLSRIALDFFVRNSMKGHLVVTSSVAGLIGAPNSGTYTGAKHALHGYFESLRNENPNVHITMFCPGPTATNFLQECFTETPGAKYNQRVQPTDRRMTSERCGYLYAMAIANKTHLSWVGTFPVNMILYVALYYPNLKRLLLKIVGGERLQRIRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNY6</accession>
    <name>A0A084WNY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004015-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020094</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNY6"/>
    <dbReference type="STRING" id="74873.A0A084WNY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020094-RA">
        <property type="protein sequence ID" value="ASIC020094-PA"/>
        <property type="gene ID" value="ASIC020094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020094"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012734"/>
    <dbReference type="OMA" id="VYYANLP"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784984" evidence="6">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="504" mass="56822" checksum="61F11A7CFA1D751A" modified="2014-10-29" version="1">MLLSKAFVLVSALCAIAVVTGSPADVRAPGVKSTRMLQELQRHFVRPVVPVDFVPKEDNITGGRFRTRVDHFDPQNRDTFEFSYFSNDEFYQPGGPIFIFVGGNFAMTTYYITHGLLYDTAARDHAWLFTNEHRYYGTSTPVSDYSTENLRFLKSEQALVDLIEWIDYLRNNVVMDPQAKVILLGVGYAGALATWARQRFPSIIDGAWGAGATVLASFDFQEHAVDVGSLIRRFGGDDCHSLLWVAFRTAQYLMDADRDETVTNLLNTCEPIEPGNLLDQETLFYHLKLAVQEAMLEDQDTDKIRTVCENMLNATEGTALEDLADWLRGYYANLACMPFDFDSNMEAGQVIAPGAPENAILGIRQTQYQACTEFGWFRTTDADDQPFGDRVTMHFFLESCRALFGGWVTDAVIYDGVRLTNLHYGGQDPRSTNVLFTNGEYDPNRFVSITSYINPLSYAYVVPDEFLYSEIYSIGEDDSQELITIKNSIQQYISLWQGEGLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP09</accession>
    <name>A0A084WP09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dwil\GK11829-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020121</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
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                <person name="Yu J."/>
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                <person name="Zou P."/>
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                <person name="Chang X."/>
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                <person name="Lv Y."/>
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    </evidence>
    <sequence length="3068" mass="326405" checksum="287648ACAF3F0C5C" modified="2014-10-29" version="1">MKLINCIAAKFQCQQEGFAVDPNDCAVFYRCVQEGDNLTAYKFRCGPGTVFSMTENVCVHPRDSEREECRETGNEIDGGNAPAPEPEPAAPETAPQMAEPVEKEPAPTNNGPSDGGNENSVNPAGNEPTGAKPDDGTEKEDKPIVDDGVPCEEDGFVGDRSDCRVFYRCIARADGTFQKLPFRCGEGTVWDDRITSCNHAAAVERCTQISQSDYIVNQESFSQSNASMDKNMTQAASSMTQNGVTTNTTSSQTSAASELSSYNNMTTWTQGGDGQGSSSASSSSSSSSSSSSSSSSSSSSSTSSSSGGNWGGNNQWNNQGSGGQWSNQNQGSNNQWQNQNQGSSGSNQWNNQNQGQNQQWNNNNQGQNNNNQWSNQNQGQNNQWSNQNQGQNSNNQWNNNNQGQNNQWNNNNQGQSNNNQWNNQNQGQNSQWNNQNQGQNNNNQWNNNNQGQNNQWSNENQGQNSNGQWNNNNQGQNNQWNNQNQGQNSNNQWNNQNQNQNNQWNNQNQGQNSNNQWNNQNQGQNNQWNNNNQGQNSNNQWNNNNQGQNNQFNNQNQQSSSSQSQSQSQQTSNQSQSSSSNNQQWNNQNQGQNQQSNNQNQGQSNNNQWSNQNQGQNQQSNNQNQGSSSNNQWNNQNQGQNQQSSNQNQGSSSNNQSSNQNQGQNQQSNNQNQGSSSNNQWNNQNQGQNQQSSNQNQGSSSNNQSSNQNQGQNQQSSNQNQGSSSNNQWNNQNQGQNQQSSSQNQGSSSNNQSSNQNQGQNQQSNNQNQGSSSNNQSSNQNQGQNQQSGNQNQGSSSNNQWNNQNQGQNQQSNSQNQGSSSNNQSSNQNQGQNQQSSSQNQNSSSNSQSSNQNQQSSSQNQNSSSNNQSSNQNQGQNQQSSSQNQNSSSNNQSSNQNQGQNQQSSSQNQGSSSNNQSNQQSSNQNQGSSSTNESSNQNQGQNQGSNSNNNNQQSSNQNQGSSSNNQSSNQNQGVNNQNQGQENNQGQSQNNQNQGSSNNNNENNQSNQGSNSNQNQGSTNNENSSGQSNNNNQNTGSNENNGQNTGGQGNTNNNQNAGSTITGSVQPTTPQVPLEQSSTTTIGTSPTTEATSESTTSTVENTSTTTPITTTAQASSTTTASTTTSTSTTTAIPTTTTTPVETTITTTEATTTSPVTAESSSTTTTVTNSPSTTGNESMPTSTPASTATTTPDVTTVSNLVSESTPTEAISSSSPNTPLPTETVSPSLAPSSETTASSASSTEATTSSITTAASSTSSSTTQSTSTSTTTVAPTTQSSSSEASETTTTVESSTPDIHTTQPSTVGEPSNSTQTPATDSTTQSTPLSSSETSPSTTQTSTSTQESSSESSHTPTSTTPSEITTQTQDTASHPLNNLLHKKSLHMHLIQRRQMLHQRHLQLRPLQENLSHNKVQQHKNPQLHKHQPPHKSLQVHKHLLPHKSLQAHKNPLAHNPQQHKVPQHKVPQHKAPLRSPQPLVLLLRQDLPPHKQVHNRPRQHLEHTYRQLQHPPVHHQHQAHKQLCSQRSLCKVLSPQPLSLPQHNLQVPQLRHHLAHLVPPTRPLTRCNPAPPLPVPRKEQAEQPLGQPHLETLLIALRMVSWVIRTIARSFTAAYQTAMVDTRDTTSAAVTVPCGMTKLPAATMTGLSIIRVAVRLLGQRLHPKVDRRVRLLRDPMVRTARAMDLTVRMDLAMDPMDLTGRMDLAMDRMDRMARMDLAMDPMDQTVPMDLAMDPMDRTVPMDLVMDLTDPMDPMDPMDLMDRMDQMDPMDQMDRNGPDGPNGPNGPNGPGGPNGPNGPNGPDGPNGPDGSGSGPNGPDGSGNGPNGPNGPDGSDNGPNGSGNGPNGPNGPDGSGNGPNGPNGPNGPEGQGESNGPNGPNGPGGPGGPNGTDGTNRPEETTTSGQPSTTVPPCQTTTTTTAPAVPAGSNGVCEQEGFMEHPSNCNKFYRCVDNGNGGYDRYEFTCGPGTVWDNDILACNHPASVQNSKCGTGTENTASSQYPGSSSGPGNTYLPPSQSSTESMPSTTEQASSSLEPESLTTGATDAPSSQQTTSSTTSATTTPGTSPTTESGKEETTASQTTESTKEETTSNAQEQTTESQGATQTTTTMGPSTTGAGDSSTTPEGATETSTMPSSEGCDSEGFKPHPTNCKMFIRCVDNGKGGFTKYEFTCSEGTAWDQSKQACNYEYEVPNCGADRPPEPEPEPTGTDMTTVGAESTTAATDGTTQGQTDSTATTTPTMTTTTSSPTDTTTPAGETTTARQDMTTAPSQETTTTPAEQQTTTTGATQDTTTTTAAGAETTTTSSQETTTAAGQETTTGQSQTTTAGQETTTGQSTTGGETTTSSPGQETTTTGESSTDSTTPGGEMTTQSSGNQETTTMAASSGKCTEEGFMANPDDCRKFYRCVDNGNGGFTKHDFTCGEGTAWDQQLQTCNHENVVEMCSGQTGNTSNNQSNQSPSSSTTSTTTTTTTTTTTTQAPTTSTQSSTTTTSSQAPPSTTTTPSMSSSQSTQSTTSSSSTSSSTTTTTAPSSTTSTTTTTTQSMQPSTESTTERMESSTASNSSKSSSSTPVNCTEAGYFPNPDDCTKFYRCVDWDGMGENFSVFHFDCPEGTIWDPAVNTCNHEESVQPPRNCSKSSSATDSTMTTAAATTTEGSPGATTDAGMTTDNAAQQTTTAAQQTDATTESMASSETTAAMQTEAQSETTAAGKEETTTQQMTTAAQETTTMAAQETTTAAAQETTTAAAQETTTAAAQETTTTAAQETTTTAAQETTTSSAQETTTAASQETTTASAQETTTTAAQETTTMAAQETTTASGQQETTTAGQSQETTTAGSEQEMTTMSQTETTTAGGEQESTTAGGEMTTSSSAQEMTTTEGMESTTKPAEECPASCTSSCPPVDEDQDRFVCPTGFKRHPKNCNLFYQCTEKPNSYDYSIVVFSCPNNTVYQEDRTQCTEPAENDDRCKANSLRSQLRTTRQQPVMQLGSKEPLCPTDGHFAIEDQKCSSTFLRCSQGRSGLQPNMYRCPKGYVYWRVSRRCERVAKIPECQSTPMQERSELPVEWINIGNRKRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQS0</accession>
    <name>A0A084WQS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025683">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525398">
        <property type="protein sequence ID" value="KFB52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020825-RA">
        <property type="protein sequence ID" value="ASIC020825-PA"/>
        <property type="gene ID" value="ASIC020825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020825"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010109"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20339" checksum="C38D0FE58607895C" modified="2014-10-29" version="1">MTFPRHFPSDSSCAHHRMCVTEDREPGGSMAVKCANDWRPPSELAANGQQRITSRPSRSSRERRRRRRRGNLSSTALLGAILMMLAVGVRSIGASYSDTDDLINELDRPMIAAPESHYGSNCVDVCEDCFRSLGSEFQGWSDSTRLLRHGRALEYVLGFFRHKNSRAPQETVTTVAASSRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR24</accession>
    <name>A0A084WR24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020923</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR24"/>
    <dbReference type="STRING" id="74873.A0A084WR24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020923-RA">
        <property type="protein sequence ID" value="ASIC020923-PA"/>
        <property type="gene ID" value="ASIC020923"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020923"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000623"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785079" evidence="2">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020923-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="17949" checksum="40F2E3925A8F49BB" modified="2014-10-29" version="1">MKAISAKRQPRHEMTSTPATFDRCIRVVLLVVLLHLCCVGSSAAEEPSSSATNLTERKHPLGNNSSANEGPLSELPKPIFCFPSPSTPSPDETEVSPRKHKTRRKGGGGGGGNGHRSKPKKRKTAMQTALQSAARKGLAAMIELYDRQEPDMLKRGKLGEWSMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR64</accession>
    <name>A0A084WR64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020983</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525403">
        <property type="protein sequence ID" value="KFB52708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020983-RA">
        <property type="protein sequence ID" value="ASIC020983-PA"/>
        <property type="gene ID" value="ASIC020983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020983"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6341" checksum="8DC86EFB929102B3" modified="2014-10-29" version="1">MSPFKTKLVTVSPAFEIKVDLLRGAYQCTVHAPRQDMRIAARCYVVCAESSRGPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRP2</accession>
    <name>A0A084WRP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021162</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021162-RA">
        <property type="protein sequence ID" value="ASIC021162-PA"/>
        <property type="gene ID" value="ASIC021162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021162"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020433"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785146" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11310" checksum="F82DCDF5D03366A8" modified="2014-10-29" version="1">MHKIQARMSLLLLLMQVSVFLLATFGTAESWPLPNIIDAPRNKDDNIPSAIAGSPRPLLDGDGKMIVYDLAATITDEGFDAMESTNIGFLWFPLFGKLNPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRQ4</accession>
    <name>A0A084WRQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006998-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00021176</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRQ4"/>
    <dbReference type="STRING" id="74873.A0A084WRQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021176-RA">
        <property type="protein sequence ID" value="ASIC021176-PA"/>
        <property type="gene ID" value="ASIC021176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021176"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006532"/>
    <dbReference type="OMA" id="QIQEAAY"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB52898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021176-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1146" mass="132380" checksum="886035F8CC09CCAB" modified="2014-10-29" version="1">MHRRGGKRIRMNEPPPDYEEPENLYQNEPLNESWSSGGHEDGAPHEDAGGEPSRGRMTRLRARGGVPLKAPIIEDDDDDFFFEKEHQKKRKAPRKPREVVPKEHTEKPPKVYHQREEREERVVVTERESTTDESSLYYILRHSKSNIASIVDDWIERYKSDKDSALIALMNFFVNASGCKGKITAEMQQSMEHTAIIRKMTEEFDEDSHEYPLMMSGQQWKKFKMNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSIHFDNAARQYEAERTKPRDRRAPDRLESLMAKRSELEENTDEIKNMLTYMFKSVFVHRYRDTLPDIRAICMSEIGIWMMKFSSNFLDDSYLKYIGWTLHDKVGDVRLKCLQALLPLYENEELKGKLELFTSKFKDRIVAMTLDKEYEAAVHAVRLVINILKSHQEILTDKDCEIVYELVYSSYRGVAQAAAEFLNVRLFCLDPSMPPTYTRRGKQRLPNTPLIRDLVQFFIESELHEHGAYLVDSFIDNNPMLKDWECYTDLLLEEPGAMEETLDNKQESTLIEIMVSAVRQSATGEPPVGRGSSRKMTLSAKEIKQVQDDKQRLTEHFIQTLPLLLHKYSADGEKLTNLLAIPQYFDIELFTTTRQEANLQALLDKMTHVMSTHVDREVLETCAKTLEFLCTEGSAIYTRCDLARSNMIDECVNRYREAIDDYRTLIAGDEIPNEDEIYNVNISLKKVSILYASHNLNPWNLFDSLYQDIDERVSGNKPDEGIPKEALVYCIEACFFSINWGLNHLETTLDRSQVAQEAHELNLNLRKYMNACNHLVRYDRESAVQEAAYMSLCDLLVVFSNQLRSHADENIQSLVFTPNDEQQVLLNEFVQTNVFATEQHEGLDETRIEELHKRRSFLAAYCKLIVYNILPTKAAADIFKHYLRHYDEYGDIIKTTLGKTREISKVNCSLTMCLSLSTLFQEIQESSKDGRVSRTSQEFLDLKELAKRFALSFGLDAVKNREAITVFHRAGIYFAVNTPDEGNEDPSAAPPRIAFLEVLAELTNKLIKQDKKFILSVLDRRLKTGIPSSRSEDWIPMVMYRNSLLHGETDQLPVTSKRAYTRKKKDADHDDDDEHDDEDEDYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSC0</accession>
    <name>A0A084WSC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525413">
        <property type="protein sequence ID" value="KFB53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021408-RA">
        <property type="protein sequence ID" value="ASIC021408-PA"/>
        <property type="gene ID" value="ASIC021408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021408"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15828" checksum="E75FB8C549E19DCD" modified="2014-10-29" version="1">MQMGKDSTDDPRKSITPPASRSGFVRYPSGTEPWARNKMANRPVGRLYAGTNLPQLVKLLRTDEKGLIRHHSEKCNHCTPLERGFKNVVQNRTKSPPGLSGPSGVLNEITKKTTHQLPDSPTAHFLYRETHVSGARSQKIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSG5</accession>
    <name>A0A084WSG5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00021458</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026530">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026531">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026532">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSG5"/>
    <dbReference type="STRING" id="74873.A0A084WSG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021458-RA">
        <property type="protein sequence ID" value="ASIC021458-PA"/>
        <property type="gene ID" value="ASIC021458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021458"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005016"/>
    <dbReference type="OMA" id="CMEPPSY"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21778">
        <property type="entry name" value="MobB_LATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000391">
        <property type="entry name" value="Large tumor suppressor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049761">
        <property type="entry name" value="LATS1-like_MobB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="707"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="37"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="948"/>
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            <begin position="66"/>
            <end position="111"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <begin position="144"/>
            <end position="168"/>
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    </feature>
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            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="374"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <end position="462"/>
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            <begin position="478"/>
            <end position="488"/>
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        <location>
            <begin position="517"/>
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            <begin position="529"/>
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            <begin position="547"/>
            <end position="576"/>
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        <location>
            <begin position="577"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="615"/>
            <end position="631"/>
        </location>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="737"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="17">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="1019" mass="109467" checksum="1B2EA6880AACFA78" modified="2014-10-29" version="1">MNGKGGKVPSSVARHSTYNAIALEQIKNELMPYETGQQLGGSQINAPLKRKPSIEKDAPQSPLHMQRTSPALDSGAGSSRSNSPHSQQPFSASALGRSSQYSPSPCPTNFSDAPPIPPPRCSSTPSTPQPPNPMHLLKRMSPASVASTRNGQFGGASSQSPARGSSPISGGGNHQLRQPIIVQNGPQVQQQLSQQMAVYTSSEPPPPYPQIGPSSPPNYLSSFHSRQSPTQSSQSTDFRKSPSSGFYSNASIGSSSPITVSQGSTGGGSAASSIQRPIPLQPKPSGAHPPPSKAAQHPIIMHSVKSTQVQKPILQTAVAPPAPAGGHPLQSIDRHNNPPPPSYAVSKHSSPKKEPPPAYLHDGGGGGGGGGGGSASPANVTGNNNSNSYAQDGFSQQQQQHYHHHHHQLHPNSGHRGMEGLSNGMHSASEQKGPPTTTKGPLKTSGAASQQQQQQQAISGAALKSLGAMMMGGHPHHNSNPQQQQHQAVSHDAKQRGMATNSNVRSSLMKTVRFPAATSNGPAPTYTNGTGGGGSPQDHGGSGSGSGESSPATTPTSTTSSSSAAPNGAGGNAAPSGSGGSGGGGAGGGGSGGGGSSGGGGEDNPRKIKHQSPIPERKNLSKEKEAERSECKVKHYSPQAYKFFMEQHIENVLKSYSQRNFRIKQLESEMSKLDLPEETKIEMRKLLCQKESNYIRLKRAKMDKSMFAKIKTIGVGAFGEVTLVKKIDTTNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKKGIFEEDLARFYIAELTCAIDSVHKMGFIHRDIKPDNVLIDRKGHIKLTDFGLCTGFRWTHDSKYYQKNDHARQDSMEAWSKFGSEIPPPLERDIKPDNVLIDRKGHIKLTDFGLCTGFRWTHDSKYYQKNGKISRRFDTWQIKYPTDTSNFDPIDPGRLQDSSSSCDEGGHGNLDEVCDSGKPFHHGFFEFTFRRFFDDESDHKITLDSSEGQAEAIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT40</accession>
    <name>A0A084WT40_ANOSI</name>
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        </recommendedName>
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        <name evidence="5" type="ORF">ZHAS_00021697</name>
    </gene>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WT40"/>
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        <property type="protein sequence ID" value="ASIC021697-PA"/>
        <property type="gene ID" value="ASIC021697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021697"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023110"/>
    <dbReference type="OMA" id="NYECSRD"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21504">
        <property type="entry name" value="PPP2R3A_B-like"/>
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    </dbReference>
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        <property type="entry name" value="serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.230:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048855">
        <property type="entry name" value="P2R3A_B_D_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="660" mass="75704" checksum="3E6D301D7C1E0D2A" modified="2014-10-29" version="1">MSSVSFLTRVTQQLHHRRPRDRLSPSKPVNRLVPPNIHTTLQRHLKNSTKAPYIPQFHFPNGKPPPTITTETTMQRLEQVFDKLPNYECSRDNFQVIVQMCQVPQYWRLPLFMCTPLTPGGCVDGDKFLTFWRQMTSVCHDAASRFVYIMSRGDRSRPYILPEDFAPLIQDVVDTHPGLAFLKEAAEFHSRYVHTVIARIYYNVNRSWTGKITTTELRKSNLLDVIQLLEEEEDINQIMAYFSYEHFYVIYCKFWELDRDHDLYIDQQDLARHNDHALSSRMIERIFSGCVTRSPRRGNNNPMIQGPNGPKMSYTDFVWFLLAEEDKSHPTAIEYWFRCMDVDGDGVLSMYELEYFYEEQQHRMESLGIETLPFEDCLCQMLDMIKCSTPGCVTLADLKRCKMTPIFFDTFFNLEKYMEHEQRDPFAQRENDDLSDWDRYAAQEYELLVAEEGGDTQGHYYVSAHPLLSNVMDTARTRLPVPPLLSGIPGPSASSTVSTVHSTSVSATTVHHSRSSKGPKVGGTRAANVGITTSATKSGTQANNNARKMHMPGHAAAAAADADAAAGRAAAPEATSQSSRKMMALDSDLNTFYSAFLVSYDEDDDYEPNIDILESQLDDCILNEWKNGDDSDESDSEKISLRISWRERYLRKRRNKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTG1</accession>
    <name>A0A084WTG1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00021732</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01026891">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTG1"/>
    <dbReference type="STRING" id="74873.A0A084WTG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021732-RA">
        <property type="protein sequence ID" value="ASIC021732-PA"/>
        <property type="gene ID" value="ASIC021732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021732"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022899"/>
    <dbReference type="OMA" id="HMTSARE"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF162">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="14468" checksum="2203A3359EDB2EC7" modified="2014-10-29" version="1">MLNSFVHIVMYFYYMVAALGPKYQKYIWWKKYLTAFQMCFACTALRVDDTPLAKGTVKELAVALSLFAIFTHPVPAAVLPTCDYPKGFMVWIGLHGVMFLFLFSDFYKQAYNKRVGRAKRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTQ9</accession>
    <name>A0A084WTQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Amine oxidase, copper containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021842</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021842-RA">
        <property type="protein sequence ID" value="ASIC021842-PA"/>
        <property type="gene ID" value="ASIC021842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021842"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="5536" checksum="DFEB0BDFBB1F2FAA" modified="2014-10-29" version="1">MTAMIAGLLEEDSVRKDRIIGQHWSINSDPSGGHGPSLVRFRGSTVVPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTU3</accession>
    <name>A0A084WTU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004553-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021879-RA">
        <property type="protein sequence ID" value="ASIC021879-PA"/>
        <property type="gene ID" value="ASIC021879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021879"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007263"/>
    <dbReference type="OrthoDB" id="6366777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8981" checksum="80A44B1A6CB25208" modified="2014-10-29" version="1">MDPSTDGLRSNDVYGVDASVLGHRADTKSREFKYAIYAMLKQLMEESAANRQELPTHLQQQQSGHQQPSFQRDLSGVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB04</accession>
    <name>A0A084VB04_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001069</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524242">
        <property type="protein sequence ID" value="KFB35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001069-RA">
        <property type="protein sequence ID" value="ASIC001069-PA"/>
        <property type="gene ID" value="ASIC001069"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001069"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="16887" checksum="0492249F874F9A40" modified="2014-10-29" version="1">MYTTKVVPTEAVGRSVTSKAADVASMHVRKNGRWEERAQSKKTARRSGQRSGSNLGPGGQGSIRNPSAANQPKQPKAASRHHGKASQRSSIGGRPTEKQANETSADGRRRGRRTIHRRTAGGEAAGQRSIGGRPADRHQRDNLNETVRRTFQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCC8</accession>
    <name>A0A084VCC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP012355-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002470</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524591">
        <property type="protein sequence ID" value="KFB35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCC8"/>
    <dbReference type="STRING" id="74873.A0A084VCC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002470-RA">
        <property type="protein sequence ID" value="ASIC002470-PA"/>
        <property type="gene ID" value="ASIC002470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002470"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013153"/>
    <dbReference type="OMA" id="HVKEHHY"/>
    <dbReference type="OrthoDB" id="7765291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF12">
        <property type="entry name" value="HL02234P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20446" checksum="992E9E0BBD8036B8" modified="2014-10-29" version="1">MALAIASAAAVDESKKEKRGLFELGSSQQESFETYGYETQHNHGYYGNDYVQKEVKQVITKEVPVPYPVEVEKHVPVEVKVPYPVEVEKKVPVYVEKKVPVYVEKKVPVHVDRPYPVEVKVPVHVPVYKKEYVEVPKPYAVHVDKPYPVYVKEPVYVEKQVPVTVHIKEHHKKPFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDC5</accession>
    <name>A0A084VDC5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00002949</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01011253">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524658">
        <property type="protein sequence ID" value="KFB35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDC5"/>
    <dbReference type="STRING" id="74873.A0A084VDC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002949-RA">
        <property type="protein sequence ID" value="ASIC002949-PA"/>
        <property type="gene ID" value="ASIC002949"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002949"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015699"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="108"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="771"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="535"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002949-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="967" mass="108656" checksum="84689AD0C44440F8" modified="2014-10-29" version="1">MIQILRNAASTPLKSLTRYVRPVVFACESVQFSTYRSSVINNNPAFNRSNGRLIPALRNTALYGNSRSFCSKNDSSSDDPVDPPVEPPVTFTNQLPATVAIPEVWPHLPVIATKRNPVFPRFMKILEVSNPMLIDLLRRKVKLNQPYVGIFLKRDDDNPNEVMETLKEVYDVGTFAQIQEMQDLGDRLRLVVTAHRRIKIVGQLYEDLDAPAPGKEMSIKYPFFKTQIGVSVDEPDAEKRRRKHKLRSKQIRNANNDHSVDGTPVEEAPKRRLLKEGEQQPLLMVEVENVKHESFKHTEEVKALTQEVIKTIRDIITMNPLYRESLQQMLHQNQRVVDNPVYLCDLGASLSAAEPAELQEILEEMDIPKRLMLSLSMLKKELELSKLQAKIGREVEEKVKQQHRKYILQEQLKVIKKELGIEKDDKDAIGEKYRERIKDKVVPKAVADVIEEELTKLNFLESHSSEFNVTRNYLDWLTTLPWGVMSEENLDIDQATKILDEDHYGMEDIKKRILEFIAVSQLKGTTQGKILCFYGPPGVGKTSIARSIAKALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNVNFLDHYLDVPVDLSKVLFICTANVIDTIPEPLRDRMEMIDMSGYVAEEKLAIAKQYLIPQAMKDSGVEDKHINITDDALNVLIKSYCRESGVRNLQKQVEKIVRKVAFKVVRKEAEFTEVSGGNLSDLLGKPIFTHDRMYDITPPGVVMGLAWTAMGGSALYIETAKRKHLEPADGADSKPVPSDGTLELTGHLGDVMKESARISLTVARNFIKQTDPSNNFLECSHLHLHVPEGATPKDGPSAGVTIVTALLSLAKGQPIRQNVAMTGEVSLMGKVLPVGGIKEKTIAAKRSGVNCIILPEENKKDFTDLPAFITDGLEVHYAATYADVYRIVFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDI7</accession>
    <name>A0A084VDI7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002298-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011470">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524684">
        <property type="protein sequence ID" value="KFB36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003045-RA">
        <property type="protein sequence ID" value="ASIC003045-PA"/>
        <property type="gene ID" value="ASIC003045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003045"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015915"/>
    <dbReference type="OMA" id="DLQDCAY"/>
    <dbReference type="OrthoDB" id="7737588at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="240" mass="27433" checksum="AD0556F394F2E33E" modified="2014-10-29" version="1">MELPSWKLAVICTLACLGPALVQGTFLLTYQNQLAELHKLMKTEIGQRFRQNSVLNAGLIEQELLPVLAECTIAIRSANQDLIERIASIRPNGTDGVSECWDTVDSLLYVHTLLPQWDLQDCAYGGYSQWMRDDARERFYPRALELHRISSEVINTIVGVVSEDDPVTDAAEVEGRLDASLDHFNEMWIDGLQDLEEDLERHNDRQQAIEAYMRECIDRTISTSQEDVEYTVRYAEFFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEJ3</accession>
    <name>A0A084VEJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003550</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003550-RA">
        <property type="protein sequence ID" value="ASIC003550-PA"/>
        <property type="gene ID" value="ASIC003550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003550"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003550-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6183" checksum="1C2B837D89B5F36B" modified="2014-10-29" version="1">MSSTAVGSANQQQGATPAAPPAGPGQQPEYGAISVIKPELDKRRIQRMFSWTAESPAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF37</accession>
    <name>A0A084VF37_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00003775</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF37"/>
    <dbReference type="STRING" id="74873.A0A084VF37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003775-RA">
        <property type="protein sequence ID" value="ASIC003775-PA"/>
        <property type="gene ID" value="ASIC003775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003775"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017687"/>
    <dbReference type="OMA" id="FYCDICT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="650"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="914" mass="100380" checksum="82C36C6BAEBE7FC9" modified="2014-10-29" version="1">MANQQRQRPTGPEKSVSESETADSLCVVCFKPIVYFAVGECDHLCCYECSTRIRVLCQQNDCPICRRDLAKVIFSKTLMSYQQLDIKNRSGLYDKKYRICFTDTEVQQAFFDLLDNKCPRCDEKNFPKFELLREHVRKKHELFYCDICTEHLKVFSSERRCYNRQELALHRRKGDPDKVGHRGHPLCEYCDTRFLDKDELFRHLRRDHFFCHYCDADGRNFFYGDYATLRDHFRSDHFLCEEGECEQEQFTSVFRSEIDLRAHRASVHGKTMNRLANKQTRTLELEFSYAPRHGPPSGPNSGAGPGGGAAGHQREYEMLVEATHQASIQQHPKKVIDATSEQDFPTLAGAAPNPMFRPNNVSIRQRVYGSAGLARTKENFPALGSGGGETTGPTSMNEGFSSKITASSLLKPSQPSGSAGTSMMIHVSNRPSGSGAGKMANAGKKNQADFPALPGSSKGAGSTAHRKAGTTSDLFADMDDRSSGGSMVNLNAMSAKNRALADDYVSVSSVVSKVSTVSSKEMKKGPQPAQQASVPSVNSTKAFPTLGDAGKPAAIKSVPWAAGASGAGTSTNGSSAASSSSSSNVSSKKKPAPAPNLREDTGYVNLNALTGKKSADKMKQKEQPSSSSNTDTRNNNGNAGTKERNREPQKQQQQQHSKSNGQSSTGSLANHTNNSNNANNNVPAVADSFPALGNHSSPEFVFAAAPKRTPPGFESVNVKRVPGPPPGFGNVTLNSVARNTNNMTFTNSTGDTYNILPSHSYVSPSNFSKRNQNLVTHFQRALKDQAALAEFRTISQMFRDGQYNASAYYEHCKIALGDRFQEIFPELIALLQNIAKQQELYLVYCQDEKSRPKSSGKGKQPNASRLEVCQVCKQVLIQTDLTEHYQTHYMENNFPKLANNALDEGKVGSSAWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF74</accession>
    <name>A0A084VF74_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00003818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF74"/>
    <dbReference type="STRING" id="74873.A0A084VF74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003818-RA">
        <property type="protein sequence ID" value="ASIC003818-PA"/>
        <property type="gene ID" value="ASIC003818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003818"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004246"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="252" mass="28818" checksum="3082177424336678" modified="2014-10-29" version="1">MVKLTPDLINQSMQYMNPCRDRELDLRGYKIPQIENMGATLDQFDTIDFSDNDIRKLDGFPRLPRLKCLLLNNNRIVRISENLHESLPNLQSVILTGNNIQELGDLEPLTKLPNLETLSLLTNPVSTKQHYREYCAFRFPSLRLLDFRKIRQKEREAANQLFKSKKGKEMHKEIMRKAKQAMPGVVGTTSPEKQAVQNATPADIQKIREAIKRATNLHEVERLTRMLQSGQITGDILNGNESATHLSNSNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG28</accession>
    <name>A0A084VG28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004093</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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            <dbReference type="EMBL" id="KFB37323.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004614-PA"/>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC004544"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS011611"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004544-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <sequence length="205" mass="23594" checksum="832B2A922F1EE177" modified="2014-10-29" version="1">MATPPDSPIEEVVYELEPARAPKPIPVALEDLCRLTKFTRQEIRVMYRGFKTECPDGVVHEDSFKDIYAKFFPHGNSSLYAHYVFKAFDVNCNGNITFRDLLVTLSTLLRGSVYERLRWTFRLYDINGDGCISRGELGEIITAVHELMGRRPHQPDDDRKAREQVDQVFAKLDLNQDGIITIEEFLEACLKDEVVTRSLQMFDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">MYND-type domain-containing protein</fullName>
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    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
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            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="MVSYCGE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1"/>
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            <begin position="935"/>
            <end position="1018"/>
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            <begin position="1030"/>
            <end position="1073"/>
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        <location>
            <begin position="8"/>
            <end position="35"/>
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            <begin position="38"/>
            <end position="48"/>
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            <begin position="85"/>
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            <begin position="709"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37740.1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005053-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1570" mass="171281" checksum="FE178D3E74626C88" modified="2014-10-29" version="1">MAKKGKAKNGAAPAEGGQEVAAPAPATTNTPVTPVRPAPEKPAKEEAPKPAAPVAPQEKKTEVAAPTSAPENGVEGETAAESKRKNSRRNRKKKTGEDVAPEQQARDAEANNLFNQKKRLRKKRSKLTRALELAESSGNAQKAALEEAATGEAALSPEELRKRLEVVENLLKHVQAKSLEEQKKVESLKSAAKAPAPAPKAEDKKEQQKPRKESESSSKNLTNEKVRKEADVKKLSTEKVQIQNEAKRLVEEKARKEQEMKKLLEEKAKKDAEAKALLEEKAARDAELARLTQAKARVETVEQKINELDQKVQQRKETEVVKPAQPGSPKQKKEQARTRKDSESSNKKEAEEKAKKEGEDKAKKEVEEKAKKEAAAKKETEEKAKKEAAEKSKKEAEEKAKKETAEKAKKEAEEKAKKEAAEKAKKEAEEKAKKEAAEKAKKEAEEKAKKEAAEKAKKEAEEKAKKEAAEKAKKEAEEKAKKEAVEKAKKEAEEKAKKEAAEKAKKEAEEKAKKEAAEKAKKEAEEKAKKDAEEKLKQEAAEKAKKQAEEDAKRKQTVEPAKQQPQQQQQQQNGSAPTTPTQDKPAAPKQDPKNNKKNNKRTPKNSVSEDEKSATKGTGSKNGPSGDFASSAEPVPVAKSQEVQSAPAPAPKAPEAAAPANAKPAPKPTNGKPAAPASPPANGKPQTAPAATAKTPEKPAQSPKTAARSSPPKTTAKAPSPPKTPAPAPASKAAAKPSTPPATKKPDPPPKPEFLKKKSPSVEKEKAPAPKTAAPAPAPAAAPAPSSAPASPAPAPATAPTPAPVPVADPAAAARLTDDALNGQKKPASTPSAAAASAAAAAAGNTNKPKPVQKKPEVPPKPDVHNKSAAKMKTPIKQPSGKASSTVTIAHRPVQNNHLTTIQSDCRSPAATELSRTEAFKKNMDIISTIADVLLSYPRSKRNRAEGATNTNDPPNAKSSFDPTSLNQQTPASLFSALFPTQSSGGSKEQPSSEPQASTSASSEPGTSGDAKAPKQKSKLDLERILRILQSTQPNAPRPVEGGEQSSTSPAGPSTSKPSETTTDGSPENPLGSFLTKDAIRALMPTLQEVNVKFNVEKQLEALNATAAMAKLLPKTLPPGTDTTEEDELEEDLLDDESEDTIEYKFTPRPVFIATICQVCKNPLKTFFHCERCRMVSYCGEEHRRIDQPPHRDLCAVLCEIASLRGGHIYQMARKLNVQEYRSLRVQTLNQIELTLKRPLQAFEREIVLFPRICLEPNCRAWNQELLTECKDCRQVSYCATEPTHLSESHRRWCKAYLLFQKLILRQRILGRIEPVLPSRIISKPTPLAANIDETFKQLYKNSSALRDECVYAVLSQIATAPLTALYAYQQTGLAFGKTFTIHLVGAELQFEGDTLDKWEAFFLHLVPEVAVLRVVFVGPELNVENLPIDIISRIRMCRTCRTKCRVVAFDFQCRTMYHDYRHSSRYQRPDLICFFNPGLHRFTGYAGLDSWPQTIRTASDAGCPMLVTAYTELESPLDLERLQRESSRALKVIRPPSVNPFGSKRPDRNFISDETAPMIFKNYFYFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIV3</accession>
    <name>A0A084VIV3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00005217</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="16"/>
    <dbReference type="EMBL" id="ATLV01013410">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VIV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005217-RA">
        <property type="protein sequence ID" value="ASIC005217-PA"/>
        <property type="gene ID" value="ASIC005217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005217"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013714"/>
    <dbReference type="OMA" id="RDYWHLQ"/>
    <dbReference type="OrthoDB" id="65481at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000341">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000112">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002572">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002685">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002700">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF527">
        <property type="entry name" value="PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759841" description="Tyrosine-protein kinase receptor" evidence="19">
        <location>
            <begin position="25"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1969"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="97"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="603"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1114"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1489"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1608"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="2062"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1864"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2382"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2418"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1869"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2389"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2425"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="2095"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB37897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005217-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2580" mass="289387" checksum="0828202547B61C8A" modified="2014-10-29" version="1">MTSSKLPVCFISFFPFLSFFSGSGTTIQSVTPKKQNNVHQNQTSFTEHIDASCGNDCYIKQNITNQDILEAREWSCIMGCNDGLNQYFRWLKAEIGTPQAPALVADSLTATALSLEWEVPERLLDVSLHRNHGPRSYLVQWRYEEVAGDWKYCRNQSMGENSTVRVDNLQPYTKYRFRVALLLSPKHDQVLTSEQSVIISTLPSGVPTSRPRIVRAVAVDHSRISISWEPGPFPNGPVLSYVLQIKELHPIGYSAIKDITESSTTRYYIFEKLDPERNYSVSVAMRNPEGEGPASITHVTTPVKPKGLEENFLPTLILGAERSILAQSYNMFTDAPTSFYSSPKQQILGTATHIRRGLIFVSDEAGYIYRVPSKPDGEHERVPILTPSAGNNFRPTLLSVDWLNDHLYILGQVRNTMLWQISRCDFDGGHLMVAIAGLQRGPDYFEVDPFNGYLFWVIGGSRADSGLFRLDLGDISNGVKHEIKPQQIVPGRNFGAFAIDHTEYRVLIADQNLNTVLSVSLDGKQVENIRNNTQQPRFEKVKSLALANGLFYWTNGTEVFAEDYHKVHNSYYHNAFPIASNNTYFSISVNLTSEQPIPISPNPPRNVQALVSPDKIKISWDVPYLLGMKGKGAWQAWRYRVELADDELFSTVIHTAEANGTSYVMDIDDRLQPNRVYAIRAAAFTLAGLGSWSSVFRVRTLRTKQQRHLVWASADGIMRSDVIGENVSTMIGRSAELDGSTVTNLAWYNDTLYVVSNSTLRLYRAAPGGVGGWVKFRELESIECVTIDPIGERLYFSNPATQMIVRAGLHGEQHEPIHSVMNVRELRFDAQRGFIYCSSGLILEAFRLNGKNRVQYFGAALFNGKQILGMTLDVDGQKVFWIVRSYQQSHLYWAPLAGTETLKQSARSLLAEEVPVTTAIPTPAPFKPNNIQLTDLTSQGPLLHFSDRLLWLKESQVVIGDLRGENLAYIRSHQLNGTRAFALIDAGEVDLVQRAGQRGHTSFNVLPATVDSSTIRVTGDWRRFNVSWAPVQNVNYTSVFYKLILKLPGARDIVQELTVPYFVYGDGPEHETIAPYTAIDITLHAFTYWRSSGFATTLRHTPAGKPSVPVDSRAFVHYRYREDSYELYASIVFRWSPPLEPNGPIVAYRVDCWTGYNSSTKSVLLDGERITSVGGRAEIQLPGRVHPNTTYYLQVRVCNVDHESEPSAVRWVSLREPGQTLPLLYVATMDQILLFDLDRGTSSAVVSTAIPATLLAELRHERKLLWVNVNGELFINDDVDGKRKLMQIPPSHGKVTALTVDWIARTVYMRVQAPTLGSNGTLHVFDLNRFENGGAEPGTLKPIVLPADPPLIDILQPFPEHRTLLAASRESRSGYILSLDPIYQQMGDVVYFNCSESDGSTEQHAVCDHYREIFDSDGRQAMTQDTSFLYWIANGTVQIQARQYENHTTIDHANSDWQWPQIEDAGALLPVQYQPYPRASCLVPAVHGVQYRPSLHQATENSLTLILPAPETHANCSMRPPGIRYRIQYRTLSSTSGQDNELHVTESYIQRATIGGLRPFTKYVFWVTLLNYYTAAFNGTMGLQIDAPDQEPTAMSTIFSTAAGAPSKPENMRALSISPSEAIVSWRPPRQKNNDRVWYEIYWETETSGRKNRQQQRVIEYTEIDDILSMNLTRLQPDQTYSIGIRAYSTSSTFSDSEAVEIRTFPEPEDIELLSINSTGMRIYWEPPVNAHRYKLQYAPVGTNNWLMLYDSHTDIHTAHTESMHEKPRDRYTHELNELLPKTLYRFSILIYYPDRDVPYMWPREAKQFGFETLADKPGTPGRPVVTQLRQDVYKVSWTPAKDNGAVIEEYGLEALVRNSKRAVRSVEADPEPEVGPQDDDADNSAGDGSVNGMDANSTTNVTAIASEPEFVDEHWSQVYNGTDIYWIIPERHAIHNNLFRVRARNSFGWGPYSEESRPIGEELSSERAIAYVVAFITALVTVVVIVFTVMIFCLRQAEKRKNFPTEPAGGSRLPDVELAILRELPRRGNFIQSTNILYSSGSVPDSEMALLPHIRRDQISIEVGPLLGSGAFGEVNEGLVKGVDGEIETRVAIKTLKKGAKEHEKQEFLQEAQLMSNFKHKHITRLLGVCIDGDELMIVMELMQGGDLLSYLRRSRSAPGQAARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSVDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLHHVREGGHLDRPKVCPNEMYELMKYCWRFSPEQRPTFRYCLEVLKALRENTSEDTQIIAPFPAKLQQEAVSNPGYLVSEPGNNAFPAGTLRYRQHGECDPALLGTPPTSSSGSSGAAASVGGPKYLELLYEDSNEEQHSHQLAQLPPQQGSPAGQEKVPILVPPTDNGYEIPITDKRCQAALARQLQESAPPPVRTASPFVAGVSGTVDACSSLDPLLPVSINMARLFPDRYVGQAGVSTMGSLDRQMVVGPVQDGLHHIAVRRGAEVMLPMNGEDVVIEISSSITDQDEWKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKE9</accession>
    <name>A0A084VKE9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cation efflux protein/ zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00005919</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKE9"/>
    <dbReference type="STRING" id="74873.A0A084VKE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005919-RA">
        <property type="protein sequence ID" value="ASIC005919-PA"/>
        <property type="gene ID" value="ASIC005919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005919"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020768"/>
    <dbReference type="OMA" id="FHLMEQG"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000002">
        <property type="entry name" value="zinc transporter 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="86"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="16">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43073" checksum="53DFE7EE7FC19612" modified="2014-10-29" version="1">MDKDQQKQPLVIEYRKNYGTSASSQPPPSPANPSEQPPQRSIIYCVHGQLANSCCELPNDLSIRKIDSHCHKPRAEGIDKIARKKLLLASVLCIIFMIAEIIGGIYSNSLAIATDAAHLMADLASFMISLLALWIAARPSTKRLSFGWYRAEVIGALVSVLMIWVVTAILFYLAVLRTIHRDFELDGEVMLITSGLGILVNVIMGATLHHHGHSHAGGGSGHHLHEEQENINVRAAFIHVLSDFVQSLGVFIAALVIYFKPDWNIIDPICTFVFSLLVLGTTIAIMRDAIVVLMEGTPKYLDYTEVMQTFLQIEGVVRVHNLRIWALSINKIALAAHLAVEPQTNTELVLREATQTVHAKYRFFETTLQIEEFQPDMEDCNQCSNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKL8</accession>
    <name>A0A084VKL8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011225-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00005920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014231">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKL8"/>
    <dbReference type="STRING" id="74873.A0A084VKL8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005920-RA">
        <property type="protein sequence ID" value="ASIC005920-PA"/>
        <property type="gene ID" value="ASIC005920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005920"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014460"/>
    <dbReference type="OMA" id="SCTASEW"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="156"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="370" mass="43218" checksum="D5B2523F449717BB" modified="2014-10-29" version="1">MAIGGFEMELLMSKMDYLQDKLQEVEQTMKSTIEKVESKLESRINAVENSLQKAMKIELQKVEQASKARHVNLQNKLTKLEKDVMQVNFKIETAVQAMEDSLKQSANTSEDNTRAKLEVLKNQLISKIENMQLQQMAETKTYQETALSKINKLYPLIKLVTLRSCRQAAKNDSDKYIIKPGINTQPFEVLCEQNNFDGGWTVIQHRFDGSVDFFRNWTEYRNGFGSLDGEFWLGLEYVHQLTKNRPHELLVEIKDFHGSYGYAKYDKFEIGSEAEKYMLKKLGKYSGTAGHSLVDNKYEMFSTFDRDNDKRSDNCAEIRQGAWWYFRCTYSNLNGRYQNTSNDQSAMTWYHFKNDYRGMSYSRIMIRDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKY2</accession>
    <name>A0A084VKY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006013</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014326">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524959">
        <property type="protein sequence ID" value="KFB38626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006013-RA">
        <property type="protein sequence ID" value="ASIC006013-PA"/>
        <property type="gene ID" value="ASIC006013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006013"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9414" checksum="40500D9BFD3C8D22" modified="2014-10-29" version="1">MVINVPATPPPPPVPGDIRPVATLRARAYGLEPLPEQQQQPNGGRLCLCVDSNGFAGEGGFIWNAVGGPSSRQCSQLVGRIRKRMHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLJ7</accession>
    <name>A0A084VLJ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Hydrogenase maturation protein HypF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLJ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006329-RA">
        <property type="protein sequence ID" value="ASIC006329-PA"/>
        <property type="gene ID" value="ASIC006329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006329"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="18450" checksum="BBC3736CF9500130" modified="2014-10-29" version="1">MLNGALLKPFLTRRSTQERKFLNVRLNLPGTEEVFEFSRAPTRHNSVATTCTTPHRTTLRTSGKSNNGPLLVRGGGGGGGATARRRRYAKTVCATCLPRYSTLSVAVARDEYRTILDGRSRDPAPVGDRSAPTTKQPSSPFPASAVNVRECPKRRDLALGATVTHFPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLV8</accession>
    <name>A0A084VLV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006277</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006277-RA">
        <property type="protein sequence ID" value="ASIC006277-PA"/>
        <property type="gene ID" value="ASIC006277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006277"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12487" checksum="2ADB6019891D37AE" modified="2014-10-29" version="1">MFVPDGLLPMDPKPGKNGADPVSREHWKLAVAQMRWRLSSQVIPRPSSNAGAGPFFPEIDWEGRAKVSVSEDVTESVRFRHASFAHLPRDGLSPGGSLKEIYRLQTFSLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM54</accession>
    <name>A0A084VM54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Calcium permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006761</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006761-RA">
        <property type="protein sequence ID" value="ASIC006761-PA"/>
        <property type="gene ID" value="ASIC006761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006761"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9890" checksum="179BC08AB69DCAC2" modified="2014-10-29" version="1">MRPNCQVCIVIIRQSRSMPARRSDGNPIQEYGQQQHPLDHNPLSPDGHGEAEQNQQGVLDASPTIADSAGKALIFIPFAIIHHASSPGIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMB9</accession>
    <name>A0A084VMB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006441</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006441-RA">
        <property type="protein sequence ID" value="ASIC006441-PA"/>
        <property type="gene ID" value="ASIC006441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006441"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009365"/>
    <dbReference type="OMA" id="MASEYFF"/>
    <dbReference type="OrthoDB" id="8048380at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="623" mass="66282" checksum="CCF8D2BC16E88BC5" modified="2014-10-29" version="1">MSTKNVYAISIERFQAKAIKGSVGSTSVGAGGGGGSDSSSSSLLSGGEATAAGSLLSDLRNDNLIDIEPGMTLQIVEEVSSKIALIKIKDFHRNDGEQAVTSTKTDRIFQCQSVHLQRIPADIWPFMIAILDPQERCEFAKRSKLFDSVKNLTMGDNVKVKWLTKNGNVMYDCTVRYIGPVEMLGPGYYFGLQLLNLNNGESPQKDDIAFVLDYMDCEPRLALIVAANWIVFSEQDFLYRGKQHHPKRNLLGSLVSSARDLNNRITRRAGGDLGSKSAARSGSKSSVNGDFQPYTQRSYTPDLTTGATGGGGGVSNRKSTDLDALCDSFSCLPMDPTGAKAMQHKKMAASISSPNLSKQDSSSSTGSSGRYVQSHPVESLMMHTHGQNHSHHHHHHHQHAVNDEAYRSSGRSSSQNSSNSSTLKHSKARTSKSGHRPTGSNTSVNSGGFLSLPDRDLVVIDPSEIDEANKSAGNVILVNPPRSPVLSPTDSGGVDLMDLLHSSSSWPAEAGVVADSQNLADKKTQTPSSLSAASYGNGGLNVGYNTGSSSASSNSTSSTSHYNHNGTATERTNGRTKSLNPLAHFGNSKPGEVPPLSTARKAARTAAVEAKPATVDVATMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMK7</accession>
    <name>A0A084VMK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001011-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006541</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMK7"/>
    <dbReference type="STRING" id="74873.A0A084VMK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006541-RA">
        <property type="protein sequence ID" value="ASIC006541-PA"/>
        <property type="gene ID" value="ASIC006541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006541"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013632"/>
    <dbReference type="OrthoDB" id="2157354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="9349" checksum="323A1549D6FE45E0" modified="2014-10-29" version="1">MQATDKNTALHLALRYGYDKLALLLLKEGHGLMGLRNRQNLTPIEYGTTEFWNTYLDNCITIKDGTELSFNVSFLKPLAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMW2</accession>
    <name>A0A084VMW2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Connector enhancer of ksr</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006661</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014631">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084VMW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006661-RA">
        <property type="protein sequence ID" value="ASIC006661-PA"/>
        <property type="gene ID" value="ASIC006661"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006661"/>
    <dbReference type="OMA" id="RMFHEVR"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06748">
        <property type="entry name" value="PDZ_CNK1_2_3-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd13326">
        <property type="entry name" value="PH_CNK_insect-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd09511">
        <property type="entry name" value="SAM_CNK1_2_3-suppressor"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.42.10:FF:000060">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049628">
        <property type="entry name" value="CNK1-3_SAM"/>
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    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
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    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
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    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
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    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="7">
        <location>
            <begin position="82"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="204"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="851"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="632"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="827"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1093"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1213"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1545"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1654"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1863"/>
            <end position="1886"/>
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        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
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        <location>
            <begin position="772"/>
            <end position="787"/>
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        <location>
            <begin position="788"/>
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        <location>
            <begin position="1014"/>
            <end position="1031"/>
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            <begin position="1059"/>
            <end position="1090"/>
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    </feature>
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        <location>
            <begin position="1194"/>
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        <location>
            <begin position="1491"/>
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            <begin position="1549"/>
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        <location>
            <begin position="1567"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000259" key="6">
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            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="EMBL" id="KFB39306.1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006661-PA"/>
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    <evidence type="ECO:0000313" key="10">
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            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1886" mass="200744" checksum="6A1F7F8950FC6A69" modified="2014-10-29" version="1">MAYINVAEWSADMVTDWLKGLDNSMYHYVQSFTNNGVGGKQLLNIRPYELEQLGMHVIGHQEIVLEAVENLKNFNYNLDKENLQFLALHVATAAHSLTKQLEFSDQEKLETAVLKDITRTITHLKALIEWLDRAPFRGQKKFDELRKQCMRFGLEVATVAMRDRFSLMPVQAIRQNAIKLANIGEYIIKDITDPIILQPASLDLVTLKKRESDLGFLIMQSFHGVHRITEIKFNSPAHNSGKVEEGDEIVQINYQTVVGWEYKKVLLQLQESPPDVLLTLKKRPKHIKIYGQIYIKPYRLPSKKRSLPYRWGESVPSPRATDTFALQDFSLLPLDRVPEKHVPSDTESDGSDILTPTDVVGGKEADKGETFRLYLPKPRAVLQRRHTLSSFKDLVGVSSWHEGRKGKPLLSSDLQHLRDKSVSFGFGLEMSPRPTTTCLGLVGGGGGGGGVPSSTGIDAVAGTVGVTGKCSSFGGLQSSLPDIVPPEVPPVVVPRQTDLLVAPPNDLAIGGVSADAYKAGVSKVVRFESSSKADQCHVDTKYTCKVDSTVLETFEPIPYVDEDLPPAVPVVVPPTVTERVKRFESFANRTKAPIITNGHHNGSTPTNGGLQSASISIAPPAPPTTTPSTVAPLKPIPMQRQLSKEPELAEAINTVVVNREMVKRGRLDKSYSTPAYDDELSDMPPAIEPRKEHLQKAPPVPPPRPKRTLPACPEPGFVSSLSNTLDSRDDNPNKSKLANVIDLKQNRTQPLPASSPTPKPAERTAIPPVPASRPAVPVPIAKIVPTPNESPPPPPPLVPTAPSPSSTVPSLPTGDSSSELLTPNKTKSLTLKKKNSLLSKRRNVSLKTLCVSDIQGHLYRRTKDRNGVSYWAKYYFVLIETTLYGFRSKEAPKANSMIFLSGFTISHAKEVHSRPHAFKVYHPYKTFYFAAETQDALVQWMEYIKQATLKGVTVGGATGGGSAAATQHTPSEFDAKNLYSETDSSDEELGLMDSTTKLNLLCTPSPQLAGANVGQGSHSMVAASNSTPTSSKPDRFNFGSLKKFTKIGSDASHQSHQSGNGGGGTGATVGSLNGSGGGNGSGGGGGGGEGSKFFGLFSSHRSVEKSNSSEMPVPTSQFKSYRKVPGAGGLQIGTASVSPDSGYPLSTGMTASPAAGMAHAADGGNFSASNLSLASGTSSTFAIPVPRETTAAVVPPPPPRATTPTPAPPPPPPPVIIREPPATPTMSEAAELLNRARKTKRISPHNYIHASNPNLVEFDFTTSKAMDFTVPKIHAGNTWDTGSHSHSGNLQSMITLKDLMLQKQAEEAQDMYNKRVCLGVEKLDDRKGGAGKRPADAQGHLSAATMAPAPAIPEAVKQIQRRQLPITPDYAQSFKLDDEDILYTRSKEGQKLRDFGYEMISGDDAFDQRNKTNRTGGGGAGSLAGSLNAGGLSISGGSSISSTGVGGSGGGGGSSGGSIKKKTFNWINSGDRKVAPDSSEGSMMTAGGVMSSSSSSSLSVSSSNTAEQQHHHRSGLSLRDSFKRGKNKARLENFKASSEKLFQFKQSAPGGGGGGGVGAGSSSNNNNDKESLKTKQLDKPATPGAIVNVNLKHQPQHIPFSGVIGVGKKNNNELNAAFEQHSALLFQQVGDAGPSGSGPPSVVGLFGTGGIKKSNTCNSSSDFKENSGKQQNMRKNSAPERGANGSGGGGGGSALTGIGNGSGGGGASSGGGGATSYFTKLSFGSTKTAKEKKLLGSPGLHRAIFGKNHQQHHHGPDQPIDHEVFSPISYTKAPSQGIQQLPTTDPGAALSLATTGGGSGIPAVMTGSTSSTGTVLTTNFGPNQPAVAPTVLDYPNMEYPPVFEPETYSLSDPSTSLTLLKRRQNHHHHPHHHQPHPHHHQSHQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMZ0</accession>
    <name>A0A084VMZ0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006694</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01014635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMZ0"/>
    <dbReference type="STRING" id="74873.A0A084VMZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006694-RA">
        <property type="protein sequence ID" value="ASIC006694-PA"/>
        <property type="gene ID" value="ASIC006694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006694"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016738"/>
    <dbReference type="OMA" id="DFMSAIV"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000208">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF5">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE E14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="25036" checksum="577AA4B5F905E309" modified="2014-10-29" version="1">MATPGMVLFYDDVSPPVRSVLLAIAALGVKDRVQLEYVNLFAGGHLSEDFLQVNPLHTVPVLRHGDLTLTDSHAILVYLCDTFATEGDALAIPDAQTRAKVFNRLCFNNGFLFQRDAEIMRKIFRGDVTNVSDHFQPLEQTLDVLEKYLSGSPYTALDRLSVADFSIVATVSTLDLIMPIKADRWPNVRGWFERMKALPYYQTENQIGLEKLREKLSTKMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNP8</accession>
    <name>A0A084VNP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Sodium channel protein type 1 subunit alpha-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007029</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014812">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524989">
        <property type="protein sequence ID" value="KFB39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007029-RA">
        <property type="protein sequence ID" value="ASIC007029-PA"/>
        <property type="gene ID" value="ASIC007029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007029"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007029-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9579" checksum="970B3CEE2C986B7E" modified="2014-10-29" version="1">MHRMQRDNGSATVGQSHFVLVLATRAAMEDGWNGKRTQKPTLAPRSVNVKGSENEARERFPGEKKDGSVASYSFATLSDRKINDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP98</accession>
    <name>A0A084VP98_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP98"/>
    <dbReference type="STRING" id="74873.A0A084VP98"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007158-RA">
        <property type="protein sequence ID" value="ASIC007158-PA"/>
        <property type="gene ID" value="ASIC007158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007158"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014939"/>
    <dbReference type="OMA" id="DMEEHDE"/>
    <dbReference type="OrthoDB" id="206950at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12671" checksum="14F6AABF49565FC6" modified="2014-10-29" version="1">MDDSSSTAIDYNPIDDIPVLPDADDIHESLLYNESPNLPSATTYKNLSSDIFTNGKASALGNLDEIDISILTACLESEQDIEEPDEVWTWDQLFTQLSVKINTETKTPIVEYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQD2</accession>
    <name>A0A084VQD2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007548</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01015189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQD2"/>
    <dbReference type="STRING" id="74873.A0A084VQD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007548-RA">
        <property type="protein sequence ID" value="ASIC007548-PA"/>
        <property type="gene ID" value="ASIC007548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007548"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000373"/>
    <dbReference type="OMA" id="YYRIRIV"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB40176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="593" mass="64727" checksum="5E9F5AA56B4855C1" modified="2014-10-29" version="1">MFGSAGSHPRTESGPGEVAGSAVEQVSKRASVRRSGSLQAQHTHSTNTQRALARFFVSVAMEREASASGGGGGGGAGEPELAVVKLGTLEEPQSPSIRSDSSSECRKSSILVYGDGHFSITLKHYDSIVAEVKCPGCAEPMDGAITMCCTGHSICAACRRKFGVCPLCGDRFSELRNYTLEAIVSKVQFPCKNAARGCTVRLPLQLLRWHRERCSYKPIECFMGKVWDACGWQGCERDWMEHCLAAHAERVYQEPTVALQWDYGDESGGQRGGAQLVVAYYVLRAHEETFNLYQVYNPDSLTVLWTVICSTKESKVSARYAFELELYSPVDTWKLLVQRFPCHSELDPDFLKDGHCVKIPLSEALRFMAEDKVLHYRVRILEVGPVGSRSLAKLDASGCSSPSCAPDYSCKHIENVNLKGVPEGNIIVRKQPVAEGTGEWYASGQPLSNGRQGDATIALADEDDDDVFLPYVDEDAAGSSPVRATGSMKLAFSVPVLAQPLVSTPPAQHGSTEVELQPIQQLVRVKMAEREEPVRMHAVYTTTKQLSRANGLVDGRAPSTDSLAKPPKGTGLSKFYNVTMYKAAKFLDKKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQU1</accession>
    <name>A0A084VQU1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007270-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007825</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015322">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQU1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007825-RA">
        <property type="protein sequence ID" value="ASIC007825-PA"/>
        <property type="gene ID" value="ASIC007825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007825"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002167"/>
    <dbReference type="OMA" id="CESHESG"/>
    <dbReference type="OrthoDB" id="7741476at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783778" evidence="1">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="491" mass="53790" checksum="9750826FC1514DB4" modified="2014-10-29" version="1">MGSLSYVCWVFCLVQVAIVSARPDFGTSLTFTQSSDIDSAVTAIALSMGSLDDELDFMLSGQISGSAAKLSLLSTFAGQLLIKGQLVTAALQGAVSSSSDVPGTFASVLDAYDELILFVNDSNEAFFGSMNEAYGGLLYQEMLDSLTFAFSKLGPSRDEFTSLQVVLTDPDAEEEVDDQLREFMLSLHSLNAHLQAMCYVFQRAGLNLQTADPFYVDYDASVTHLYEPATSAMPLEVYDAMASTLGMGLSGLVSSSPASNDLLTALLVFTQTSPDLVLEFKNALALNVDFYVEFIGDLVGEAYFQGSKVFSAANLLVNGLIDSDVFAEYCFAKYSTLVGDLPTLALIHLKECLDTERPRWRKFRRAVRSFVTLLSYDVEDLWINLETCVKHKTRRDACLADLTALYTTLGEDHQTKHDLLQDFIQAELSASRTRLTICGAAADFYILDNLVFTLLEDMTSCFEGHDCMAGMCESHESGEDMMMMPPPLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR92</accession>
    <name>A0A084VR92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007974</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525019">
        <property type="protein sequence ID" value="KFB40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007974-RA">
        <property type="protein sequence ID" value="ASIC007974-PA"/>
        <property type="gene ID" value="ASIC007974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007974"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6729" checksum="868E9CE66FC56F45" modified="2014-10-29" version="1">MAFYSTFPSASASVDPARCPSHGTSFLFRRGELSGHRSSASSLAVRAGEFPTPRTTPERELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRB9</accession>
    <name>A0A084VRB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP003014-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008006</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015600">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRB9"/>
    <dbReference type="STRING" id="74873.A0A084VRB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008006-RA">
        <property type="protein sequence ID" value="ASIC008006-PA"/>
        <property type="gene ID" value="ASIC008006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008006"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008797"/>
    <dbReference type="OMA" id="CFRDYGT"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="407" mass="45463" checksum="A326F2AF7AEA43BD" modified="2014-10-29" version="1">MAELKFEAPLAQFEESDEWGPAPLAQFEESDEWGPVEYQSSNGGGTNNKADDDLNELNDNLLLGDDTVRGDDTTNTTNSATTANNNNNIKVGPLKDNVDFAEAFTGSLEDLVNTFDEKITKCFGNYEQSVEELAPVQVRSQEEIMNECQMWWTITGNFGNILPIDWSKTYARQMHVPALKLGMRKPGTPDDELLQDLSSEDEAVANDLDMHALILGGLHADNEPIKTADEVIKEIDDIMDETGSEDGQLESEVIEKAKEVLGSPLYEEKLRSLSITQLNELYMEMEVLIREFSETLISELALRDELEYEKELKNTFISLLLAVQNRRRQYHVEKKKGKAASKGSAGAQNSTGMDPKYLTTVIPYQLNSTPDNQTLQVLIKILKAINEDSPTVPTLLTDYILKVLCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSC2</accession>
    <name>A0A084VSC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Retrovirus polyprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008392</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525041">
        <property type="protein sequence ID" value="KFB40866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008392-RA">
        <property type="protein sequence ID" value="ASIC008392-PA"/>
        <property type="gene ID" value="ASIC008392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008392"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008392-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="15911" checksum="5634AC708495E739" modified="2014-10-29" version="1">MSGGQTGIGFTLNSGGGSVFVHAHRTTSTQGQVPPNECPNSSCDRKEHLAAAGNNPQRARVRTHTGVLHPTTPTGTELLWPKGRLSDLGRIVQRPISADIRAVPANGPSELIVSCAPKTPWLGIQSHERTRIKVGDHSVKFSRKYSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSU8</accession>
    <name>A0A084VSU8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">ZHAS_00008663</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01016141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008663-RA">
        <property type="protein sequence ID" value="ASIC008663-PA"/>
        <property type="gene ID" value="ASIC008663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008663"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006808"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009361"/>
    <dbReference type="OMA" id="QRYDYFE"/>
    <dbReference type="OrthoDB" id="6019201at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042335">
        <property type="term" value="P:cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042303">
        <property type="term" value="P:molting cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009886">
        <property type="term" value="P:post-embryonic animal morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09820">
        <property type="entry name" value="dual_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000208">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000008">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000020">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000059">
        <property type="entry name" value="dual oxidase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034821">
        <property type="entry name" value="DUOX_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF144">
        <property type="entry name" value="NAD(P)H OXIDASE (H2O2-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1021"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1162"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="814"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="1212"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KFB41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1496" mass="173294" checksum="8F746FECB43C00B4" modified="2014-10-29" version="1">MESLRANRAKVHHSPAIESSLMSHVEKQRYDGWYNNLAHPDWGAVDNHLTRKAPSAYSDGVYVMAGSNRPSPRKLSRLFMRGTDGLPSMENRTALLAFFGQVVTNEVVMASESGCPIEMHRIEVEKCDEMYDRECRGDRYIPFHRAAYDRNTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFQDGALLTDKQGTMPVKNTMRVPLFNNPVPHVMRMLSPERLYLLGDPRTNQNPALLSFAILFLRWHNVVAKRVRRQHRDWGDEEIFQRARRVVIASLQNIIAYEYLPAFLDKELPPYDGYKADTHPGVSHMFQAAAFRFGHSLIPPGLFRRDGQCNFRRTNMDFPALRLCSTWWNSNDVLDNTPVEEFIMGMASQIAEKEDPLLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARAAYRLPKKKTWREINPQIFERQPELMELLIDTYDNRLDNVDVYVGGMLESDGRPGELFSAVIIDQFTRIRDADRFWFENEDNGIFTKEEIDEIRKFTLWDIIVNSTDIEGDEIQRDVFHWKQGDPCPQPEQLNATLLEPCNYLEGYDYFSGSELAYIYSCVFLGFVPILCAGAGYCVIKLQNSRRRKLKIKQEAMKNAATGKISVEKSVAREWLHANHKRLVTVKFGPEAAIYTVDRKGEKLRTFNLKHVDVVTVEQSQENYKAKKPYILLRVPNDHDLVLELESNSARRKFVKKLEDFLVVHKKAMTFVESNRDLMLAKAETRERRQKRLEHFFREAYALTFGLRPGERRRRSDASLDGEVMTVMRTSLSKSEFAAALGMKPDDMFVRKMFNIVDKDKDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSVTDDQVNELIDGMFQDVGLEHKNHLTYEDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFHIEPISDSRRHWMQEKWDAYTTFLEENRQNIFYLFIFYVITIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLLTKLKEFPIQQYIPLDSHIQFHKIAACTALFFSLLHTVGHIVNFYHVSTQSIENLKCLTKEVHFTSDYRPDITYWLFQTVTGVTGVMLFVTMCIIFAFAHPTIRKKAYKFFWNAHSLYVLLYALCLIHGLARLTGAPRFWLFFIGPGIVYTLDKIVSLRTKYMALDVIETDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTEIKPEEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPDDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSMFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKSRKWPYFIHHFENFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT98</accession>
    <name>A0A084VT98_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008755</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT98"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008755-RA">
        <property type="protein sequence ID" value="ASIC008755-PA"/>
        <property type="gene ID" value="ASIC008755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008755"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="2714308263264C8B" modified="2014-10-29" version="1">MPKTSSTFVVYTGEKRRGGIFPFPVPPFSSHRSPVSWSPQPPLPQVRILPGPLGNEMARYVGGLQPVPALEPIRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTX9</accession>
    <name>A0A084VTX9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00009028</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="ATLV01016551">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTX9"/>
    <dbReference type="STRING" id="74873.A0A084VTX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009028-RA">
        <property type="protein sequence ID" value="ASIC009028-PA"/>
        <property type="gene ID" value="ASIC009028"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009028"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004783"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009028-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="226" mass="25710" checksum="18B8CE32FCBCE1D4" modified="2014-10-29" version="1">MEVKKEQENIYLFVPNIIGYARIVLAIVSFYYMPTDYVIASWCYIISVLLDALDGHAARHFNQSTKFGAMLDQLTDRCGTCGLLVTLSYFYPKYMFWFQLSMAIDVACHWFYLHTTVLQGKTSHKFIDMSGNPIMRVYYTNRTVLGFMCLFNELFYAALYLLHFTPGPLLLGFSSFKLLAIVSFPVAVVKTGISVIHGFVASCNIGVIDVAERAAQREREANKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV55</accession>
    <name>A0A084VV55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Orotidine 5'-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009692</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009692-RA">
        <property type="protein sequence ID" value="ASIC009692-PA"/>
        <property type="gene ID" value="ASIC009692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009692"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7945" checksum="A3408A4714539DED" modified="2014-10-29" version="1">MKKKKYSDVTTDITEGAALNGPFQTIHLGAQTVGPSVRGRGCGINCLYFLHDTLYEIEASPALLSRRLEEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVG2</accession>
    <name>A0A084VVG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000748-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVG2"/>
    <dbReference type="STRING" id="74873.A0A084VVG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009524-RA">
        <property type="protein sequence ID" value="ASIC009524-PA"/>
        <property type="gene ID" value="ASIC009524"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009524"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006681"/>
    <dbReference type="OMA" id="FPEANWT"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF13">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9437" checksum="53D1FD3A9F5A07A5" modified="2014-10-29" version="1">MFPEANWTASNSVAGKRDRDQEREAQHWIETVVGEKFPAGYSYEDCLRDGILLCRLMNRLSPGIVPKINTSGGDYKMMDNINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWX9</accession>
    <name>A0A084VWX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007596-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00010177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017808">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525192">
        <property type="protein sequence ID" value="KFB42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWX9"/>
    <dbReference type="STRING" id="74873.A0A084VWX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010177-RA">
        <property type="protein sequence ID" value="ASIC010177-PA"/>
        <property type="gene ID" value="ASIC010177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010177"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008917"/>
    <dbReference type="OMA" id="NCWLPIV"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="309"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010177-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="692" mass="75848" checksum="9703B2BD3FFAEB10" modified="2014-10-29" version="1">MSASTPTQQTGAGGPPVPPVKPVLSSPGAYMANFQGTTGGGGGATVPTPPITAGIHGTNKTHEKPTIAARPIPPPKLPNYSSSFNKIDRDRNEFTKIDKAEREKLATKREMFFKSESNSPSGPPPNPPVGLNNLNLANNNVIHNNNASHLNSANAGNDKHSAAIPNAAATNNSSTGSVSIGAIVSNHSTNNNQHTSLNGGAAGTGSATNGSAGGGMAMANNGGSVNGLATSMNSISLKEKRDALLNHHDGSGANGHHNHHVESSLVNAKLAAERHDKEKPTLKSKPKELDGYVGFANLPNQVYRKAVKKGFELTLMVVGESGLGKSTLINSMFLSDIYHAEQHPGPSKRIKKTVAVESTKVLLKENGVNLTLTVVDTPGFGDAVDNSNCWIPIVDFVESKYEEYLTAESRVHRTALPDSRVHVCLYFIAPSGHGLKPLDIEFMQRLCDKVNIIPVIAKADTLTPEEITLFKKQILNEIAQHKIKIYDFPDPLDEEEDAKVLRQLRSRVPFAVVGANAIIEIDGRKVRGRRYPWGVAEVENLDHCDFIALRNMVIRTNLQDLKDVTNNVHYENYRCRKLAGLGSDGKAKLSNKNPLAQMEEEKREHESKMKKMEAEMEQVFEMKVKEKKQKLKDSEAELTRRHEERKKALELQIRELEDRRKAFEMEKAEWEQQNGVTLDELRRKSLEANSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX52</accession>
    <name>A0A084VX52_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00010257</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX52"/>
    <dbReference type="STRING" id="74873.A0A084VX52"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010257-RA">
        <property type="protein sequence ID" value="ASIC010257-PA"/>
        <property type="gene ID" value="ASIC010257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010257"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013564"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="425" mass="47353" checksum="2405C240145BC45B" modified="2014-10-29" version="1">MGELTESGKRTKFEHLVVDTSVFIKNVQLQNIAENCYTVRGVIREIKHDRQLKALAVLPYNLKVLLPDPEALAKVIAFAKKTGDFASLSLVDLEVIALTYELEARYVGEGHLRTEPKPAVTLANPTETIDLLGTEEIAGFYKPKQAANSDQPDNEPQDDDSENDEVSAEQLPKPDDHGEENGEDHNEEEEHEEEDHGEGSSDEEDDGGDDEEDDGGDEEDDEGWITPANIAQVKRGYGMTYSEEVPSVVACITADYAIQNVLKQLGLQLATMDGYVITETRTYILRCYACFKTTPDATKVFCPRCGNQTLKKVAVSLDANGQQVIHINTRRPLTAKYKNRPVAKFAGGKYATNPVLFEDQPLPQQRISAKARSKTNALAEDYTAGLSPFVMRDVDSRSAVLRGSTNLKQRMRNFEYDNKRRGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYE0</accession>
    <name>A0A084VYE0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00010860</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018359">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYE0"/>
    <dbReference type="STRING" id="74873.A0A084VYE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010860-RA">
        <property type="protein sequence ID" value="ASIC010860-PA"/>
        <property type="gene ID" value="ASIC010860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010860"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008965"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015402"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019936"/>
    <dbReference type="OMA" id="PHANAFP"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018410">
        <property type="entry name" value="Na/H_exchanger_3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01087">
        <property type="entry name" value="NAHEXCHNGR3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="283"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="919"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="945"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1193"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137270" checksum="5A8BFF1B5A3020E4" modified="2014-10-29" version="1">MAVTLKQEVNLSRRACRLDGSGRNRLSTHKTALEYPRRRPSSSSSSRCSPAPCDVPVNLLDRGNTNRGAYPELEKSSHPGANNYVPTMPPTRANECCDRPVYRRNGHRNEAEEDVTMLASLLATLTVGVLATVRKGSELGQRCQLGKLCIYVVLCSALLSNDAFVLARPNLSAPVDGEKVVAVPVGQLSPLDLAFDTSGGDGSSSSISGGPLTSASQLKRSAEAAPILASTDATVAADAAGDHGAHGARSGEEEDGKHPHTRYPVSQTDFSRVETPFVIGVWILSASIAKIGFHMTPKLSRVFPESCLLIVVGVIIGVLLRYATNLHVSPLTPNTFFFYMLPPIILDAGYFMPNRMFFDNIGTILLMAVIGTIFNIATIGASLWACGQTGIFGVDLPFLHIFLFSSLIAAVDPVAVLAVFEEIHVNEVLYIVVFGESLLNDAVTVVMYHMFEVYNEIGASQIIATDIVAGIGSFFVVALGGTIIGVIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVEQNVSHKSHTTIKYALKMLSSSAETIIFMFLGVATVNNKHVWNTWFVLLTILFCSVYRIFGVLILSALANRFRIHKLTKVDQFVMSYGGLRGAVAFALVLLVDVKHIPLQPMFLTTTIAVVYFTVFLQGITIKPLVKILNVKRSSKRKPTMNERIHERFMDHMMAGIEDIVGKTGNYNIRDKFKRFDNRFIRPYLIKNLQGPEPKILETYSKLTMRDAMDYMRRNPSTIGQMSGTESMSALFRNYTSYFGGSPSFTNLENSTRNLDMQELDYNPSKKDLTDAKIHHLLSEELKPYRRARRLSYSRHAVDDRDLSTQVNYKMQMNIRRMISEKKHHKRSKRVKDGKQQNHVSFPEFVQNGSAKQFANDYINEVLHEDNEDEERQAGPAEDWDGGGLTFTAKSSLDEKGAEKEDKRFSRESRAFESEQRVATPTAIEAVLPWKRVDENDENGAIKQNEFPSWASNKEYLAYNSPSATFLGGLTQPKQAKSVIGLFRRESSGSGGVVIGGVTDSETSTPVAATTPVGRGAAVPKDKRSASIAGYITLDGGDPSANQVLDPLGISRAVPHANAFPVTASHRRNNRRGSMLELSGEAIPEENYTKSLPERDKYGARRGPGLIKASSTNTPKSASRRPGGGPVNPQTTALLSASSTDEDDDDDDDDGADDDRRGDTRAGSAGRRLNGATEDPDEDEDDDEDEDCADEQHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ06</accession>
    <name>A0A084VZ06_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010977</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC010977-RA">
        <property type="protein sequence ID" value="ASIC010977-PA"/>
        <property type="gene ID" value="ASIC010977"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010977"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010977-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="16885" checksum="58FAE30470052D66" modified="2014-10-29" version="1">MEKVLIVTLLKSLPNLDESASADGGVESATSSEKLVATEAPGKRPDGGIIGCTFGARFLANAGPNSVPTSRWAINKWFLSRQSTVTTAAAATNNNWASGWQPGGWASCFISSQRGQQPAQTSLTRCLSYDGVSRRKQNQPGAEGSEPVPGIGPPGVWLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W096</accession>
    <name>A0A084W096_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001107-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011583</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W096"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011583-RA">
        <property type="protein sequence ID" value="ASIC011583-PA"/>
        <property type="gene ID" value="ASIC011583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011583"/>
    <dbReference type="OrthoDB" id="7742011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8012" checksum="F2C06FCCAE74A381" modified="2014-10-29" version="1">MEAANSSAKLAKDDVLTASISSEDSDSWTLLGKNADQLDKEPSGVEILKTESEEVVPVHSDRKQRHDSQRSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0F7</accession>
    <name>A0A084W0F7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP001185-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00011432</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0F7"/>
    <dbReference type="STRING" id="74873.A0A084W0F7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011432-RA">
        <property type="protein sequence ID" value="ASIC011432-PA"/>
        <property type="gene ID" value="ASIC011432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011432"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019429"/>
    <dbReference type="OMA" id="FVGWPII"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF5">
        <property type="entry name" value="FI02094P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="599" mass="65632" checksum="41654DC6A34C0C62" modified="2014-10-29" version="1">MAGLGVDDVKVSLQKFGLYDYVVFVLMLLSCVMIGIYFGFMKKKAKKGEAEADYLVGNRQMKIIPVSLSLIASFISGITLLGTPTEIYLYGVQYMYIIGGVISMGFIMMYFYLPVFHNLKLTSTYQYLQTRFDKRMRLFGSILFTLATMAWLPIVIYVPALAFNQVTGINVHLITPIVCVICIFYTCVGGLKAVVWTDVVQTVLMFGAMLLIIVKGTYDVGGLAVVMERAKSSGRIEGPDLRFDITTRHNIYSCVIGGVVYWLKSNAVSQNMIQRYLSLPSLAAAKKALWTFIFGTLVLLFLCCYSGLLIYAKYYECDPLTTKLAKAKDQLLPLLVMDTLGDFPGLPGLFVAGVFSAALSSLSTGLNSMSAVVLEDFFKPFSNRPLTEKQTSIIMRAVVAVFGTICVVLVLVVEKLGSVLQLSMSLGSVSNGPLLGIFTLGYTVFASVTCFSFQGAIVGGAVGLAVMIWICLKAQLAIASGEMAFELKPVDTQGCSYHFIASEPMSMLAINTTAPSIDSTPIEPEFAIYHISYLWYTMIGALVTIIVAVIVSFIVGANNPDDMNPNLFSPFIQRILIRRRIAARTDLQLVTGGIKEFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0L4</accession>
    <name>A0A084W0L4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP001269-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00011496</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0L4"/>
    <dbReference type="STRING" id="74873.A0A084W0L4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011496-RA">
        <property type="protein sequence ID" value="ASIC011496-PA"/>
        <property type="gene ID" value="ASIC011496"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011496"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015971"/>
    <dbReference type="OMA" id="TEVCSEC"/>
    <dbReference type="OrthoDB" id="10072647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011496-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="696" mass="73821" checksum="DDEAF473C42E3350" modified="2014-10-29" version="1">MNESSIAVERTTEVDEKMDDNENYIECTKMNFSQFNSFAGPLAANQFASAKFPQNLSTAAANGQVVGLVSGSEGAMQFLRPMDGTAVSTASAVFQQHPASHGQIVTTAGLPQGAIASPAYITLPITMPGAKPGDAQQTVQIQVLNPNPLPSQMTPGGGTGGGQGQGSGALQTPKFQMGQMQIPIQGFQQGTTVLTVAYSPQDEEVLHNQGLPEGMTIVAALQPQDLQLLASQNPGTTTILQQHQQAQANLSGNERKVDSENPPPLRQIKQEAPALWNHQSAFNHNQNTSNASAIMNGVHHPHLVLPSGIAIGPGIIKQEIITDDHSNENTQFGAADSSGQIENGGSPGRGGREDGENGGNEATGTNNGGGTEANVNGGVGGKARKKRKYKTKPPKPKRQKPGQVHITTAIDGTVLFCCPECHMAYPEKECLEQHLVVHKIERRFICDICGAGLKRKEHLERHKLGHNPERPFICNVCKKGFKRKEHLNLHFVIHSGVKTEICNDCGKGFYRKDHLRKHIKSHLTKRLKEEKASNRTSNNNNNSNSSNRNASNGTADTTVNGTSSSTTGSTTATSLPAGIPPGLTITTSSASLQAGGVDSASAAVHQTMQNLLQSAISLPQGVTIHVPTADNQTLPVQISLSPMVTQQPTEPDGSTRTVLVPASPENLQHLQNHPSQQASSQQQSSNNPGSSPSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1U8</accession>
    <name>A0A084W1U8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00012031</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084W1U8"/>
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        <property type="protein sequence ID" value="ASIC012031-PA"/>
        <property type="gene ID" value="ASIC012031"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC012031"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007479"/>
    <dbReference type="OMA" id="SKMPYYE"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:neurotransmitter:sodium symporter activity"/>
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        <property type="term" value="F:osmosensor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042065">
        <property type="term" value="P:glial cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
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    <dbReference type="InterPro" id="IPR002944">
        <property type="entry name" value="Na/ntran_symport_inebriated"/>
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    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF303">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01205">
        <property type="entry name" value="INEBRIATED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="325"/>
            <end position="343"/>
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            <end position="835"/>
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            <begin position="1"/>
            <end position="16"/>
        </location>
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        </location>
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            <position position="331"/>
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        <ligand>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Z6</accession>
    <name>A0A084W1Z6_ANOSI</name>
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        <name type="common">Mosquito</name>
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            <taxon>Endopterygota</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="20"/>
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            <begin position="21"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12096" checksum="8446EE9969CFFC06" modified="2014-10-29" version="1">MKLLCAILVIVSVLLCFGRALTLVDSADDMLAEESRQLQSDTIVPADGTVREKRGLKYQYHYKEKSVGGLFPFKQTIERKVHIKHGHGLLGGGHYREVTKVKQFGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2C4</accession>
    <name>A0A084W2C4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012309</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2C4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012309-RA">
        <property type="protein sequence ID" value="ASIC012309-PA"/>
        <property type="gene ID" value="ASIC012309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012309"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10317" checksum="58FC345F7A4293EE" modified="2014-10-29" version="1">MNRTYVSFRIRGWENPYKNPQSDLRSADEGGCAGCESTPDTPGFPPAMTTAGAKKNVVFSTGCTVKKLRSPTASRGSTDFQHRRKNNGRLRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2H0</accession>
    <name>A0A084W2H0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005324-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012196</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2H0"/>
    <dbReference type="STRING" id="74873.A0A084W2H0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012196-RA">
        <property type="protein sequence ID" value="ASIC012196-PA"/>
        <property type="gene ID" value="ASIC012196"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012196"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003546"/>
    <dbReference type="OMA" id="MLYENET"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012196-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="17004" checksum="CE3D5BF6ECB5A260" modified="2014-10-29" version="1">MFNRLRMRKEKPSKSETISTATTTVIQNAAKDNNKLILDNSRWEASFSTLNPGRPRRLQKELMSLIKEPPPGVSVDEDSVSQNLTQWIINIDGVEGTLYEGEHFQLLFKFNNKYPFDSPEVTFIGSNIPVHPHVYSNGHICLSILTDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2H4</accession>
    <name>A0A084W2H4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00012200</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01019619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2H4"/>
    <dbReference type="STRING" id="74873.A0A084W2H4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012200-RA">
        <property type="protein sequence ID" value="ASIC012200-PA"/>
        <property type="gene ID" value="ASIC012200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012200"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018101"/>
    <dbReference type="OMA" id="MAPKQPC"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="120"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012200-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="694" mass="75793" checksum="0CA18DD490354E09" modified="2014-10-29" version="1">MMLGASALDGVGGVVMQQQQQQQQQHRASDVRKGAVGAAKPIQSVDRTTSSSNETIEQDRDRGDRDRDRDRDRDRDDEDAGDDRDADGYTSEEEEQECRDDYCRGGYHPVKLGDLFLQRYHVIRKLGWGHFSTVWLSWDLEEKRYVALKIVKSAQHFSDTAKDEIHILKSILNADPTDPKRSKVVQLLNDFRITGVNGTHICMVFEVLGHNLLKLIMKSNYRGIPLANVKSIIRQVLEGLDYLHTKCKIIHTDIKPENVLVCVNESYVRKLACEATEMHAMGCKLPISLISAAPPQFQEQPASTNMSKAKKKKMKKKAKLQTELIRQQMEHIQQLEFGALENGTTDATGPEQLTIGGGSGDGHTREDKGRTESVTTEKSSTVDLTTTATATTTGNQLSETTRLLLNGTGGGGSEGLGAGGGGSSSSGEEDRPTLTPNASTLSSPSVSEATSSNNNDDHGGGGGGGGQTGDKKCRGDGAGSPGDCKSPEKPSSSCANSVTSASKLDISESVRKILSSVKECKDPAFEVCGIDVKIADLGNACWVDKHFTEDIQTRQYRSLEVIIGAGYDTSADIWSTACMAFELATGDYLFEPYSGNDYCRDDDHIAHIIELLGPIPKRIALSGKNSSHAFNSKGLLKNITGLKPWGLVDVLIEKYEWPVADAYEFSDFLKPMLDYDPRTRATAADCLQHSWLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2W5</accession>
    <name>A0A084W2W5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012439</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2W5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012439-RA">
        <property type="protein sequence ID" value="ASIC012439-PA"/>
        <property type="gene ID" value="ASIC012439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012439"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="206" mass="23089" checksum="E93B9F364B3AF4D7" modified="2014-10-29" version="1">MDKDVAVMELLQCIKAEPDDEMDTNDSNANDLMMSAEAAGSKSTNRLNKTEIERSVKQNGHPLSSASQGSGLHPSSECLNQEIVVNYIKKVENRVTLVSTKMDKLLNSITSSRGCSRTRRSNTPEAFEFSPITGEDELIDFDKQLEEKEYFEKMLDWANNRRHGFRGPQGNACEELDTEIDGIGIGGLRCCQPEFHRVHCAVTEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W337</accession>
    <name>A0A084W337_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002773-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012516</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019804">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W337"/>
    <dbReference type="STRING" id="74873.A0A084W337"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012516-RA">
        <property type="protein sequence ID" value="ASIC012516-PA"/>
        <property type="gene ID" value="ASIC012516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012516"/>
    <dbReference type="OrthoDB" id="10525338at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="25254" checksum="38367211DA7CF1F3" modified="2014-10-29" version="1">MRRESEPIYGSASASNSLNNLLHHHGHVLHGHPHHHGVQQSSHPSPSGQLSSGAVVESPLGNQPPENGTLAGSTALVDGPSEHPGLQAAFHSHLLHQQEQQHLQHHHQQQQQQQQQVEQQLHQHHRALSPTTSGGFAHGGFPGLSNGSSGGSYPGLNSFGSSLSNVNASVSGRSTNHPATSSLDEYVDILQVQQLLLENSTSVSASNGRHNSGEHNYDIPHIHHQHHHQHIHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3H0</accession>
    <name>A0A084W3H0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00012666</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Ubiquitin-like modifier.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525289">
        <property type="protein sequence ID" value="KFB44764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3H0"/>
    <dbReference type="STRING" id="74873.A0A084W3H0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012666-RA">
        <property type="protein sequence ID" value="ASIC012666-PA"/>
        <property type="gene ID" value="ASIC012666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012666"/>
    <dbReference type="OMA" id="MEHAVGK"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038027">
        <property type="entry name" value="Ubiquitin-like_Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9271" checksum="3179AFF44A2D2064" modified="2014-10-29" version="1">MATSKVTFKITLTSDPKLPFKVLSVPETTPFTAVLKFAAEEFKVPPATSAIITDDGIGINPQQTAGNVFLKHGSELRLIPRDRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3N0</accession>
    <name>A0A084W3N0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012734</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3N0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012734-RA">
        <property type="protein sequence ID" value="ASIC012734-PA"/>
        <property type="gene ID" value="ASIC012734"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012734"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012734-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8238" checksum="29C75A5D02AB1B2E" modified="2014-10-29" version="1">MQRSLYELLRSHRRTLTNVGCRTKIKLVPPLRRQVVSRAAMLIRNGVLRRNLARRKRRADGKIGSNASKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3X6</accession>
    <name>A0A084W3X6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004384-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012834</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020199">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3X6"/>
    <dbReference type="STRING" id="74873.A0A084W3X6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012834-RA">
        <property type="protein sequence ID" value="ASIC012834-PA"/>
        <property type="gene ID" value="ASIC012834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012834"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004883"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016654"/>
    <dbReference type="OMA" id="AFLCVSY"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000320">
        <property type="entry name" value="Monocarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000449">
        <property type="entry name" value="monocarboxylate transporter 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF293">
        <property type="entry name" value="HERMES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012834-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="784" mass="82867" checksum="6350C65CB085F5DF" modified="2014-10-29" version="1">MVGKPGNHRSAGGGGGGPTADKELDLEDGTNEDDYELVPPDGGWGWLVLAGSMLVNILVPGTIKSFGVLFVEFLEAFQASPSAAAWIPALCYFLYSSLGPLSSILSVKYSYRTVTIVGGTFAAVGMIITYWATSVNYLYVSYGVLVGTGAGLSFPPTVYIVTSYFVRLRGLANGLCISGSALGSIILPPVLRFLLETYGYRGACLIMGGITLNVWVAAIFYEPVEKHMKRVRKRIQPSGDDDDEENEPLATVHGRGGGVAGGEDTILEECESNDTDPHEHSDLVRQSSTKQLAASKKPKFAITGDDTPTISTPTLEHKSPDIFRFNPKNGLLDGFARSVSAAAVPVSYGRDKEELLGGGGGGGDGSTRRQRKISTPIKEEHRNLTFTSQLSSTSIPPNDSSTGLGSYFRLNRLNSIRSGLHGHAGGGTSNTTGASGRAPKRSPSTSSFQYMSTPFHGSTLSTHQPKEFASHLSLRSFGGSVTRGKPNATGDDDPTNAGGTIADGTTTEGADGKQDPKPARASMGKTFFDLSLLSDPTYLVILISNSTNAIGYTNFIILLPAYAISLGFDKSLAAYLLSIVSTLDLVGRIGGSALSDTNLIPKTWYFVGGLSISGLALALLPTVRDYTMVSVFCGLFGLASGTYVGITAVIMADMLGTERLTSSYGISLFVNGILQLVGPPICGVIFEQMGRYQPLFTALGFILLGGSALWGFMPFINRQKRRKAAAAAAEIEQQTLNNKQGTTLSPVRGHNVNTNDNGDGDNDDDDDDDDHGGPKSTGKSLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M6</accession>
    <name>A0A084W4M6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Impaired sucrose induction 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013128</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013128-RA">
        <property type="protein sequence ID" value="ASIC013128-PA"/>
        <property type="gene ID" value="ASIC013128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013128"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013128-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="22756" checksum="42CB4B45E22842DB" modified="2014-10-29" version="1">MCLTVASIDHSIIRIMEEAHPRRQKRRDTSLQIEGSSFTELIIAHACSEESQPCADVIGKSAAFLGETRAVNHRMIVTNVTSFVPKQEEANLVPLVLVYVRRTRRTRTCLSASQAKRSICLMKLLQPLISQHFAIANMFTFFRERTAPLFLSLAVWLVVISILLLAIMHRKTNRRHYSTQRPPASWQDTARWCSPISPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5F7</accession>
    <name>A0A084W5F7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013387</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5F7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013387-RA">
        <property type="protein sequence ID" value="ASIC013387-PA"/>
        <property type="gene ID" value="ASIC013387"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013387"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013387-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13750" checksum="3367109ADFECAB70" modified="2014-10-29" version="1">MTIIMSIRWTSDEQLVGGSSDGFSDLGSTEAAKLRSGKATPAWALRLKHIVVLAAFSSERQDDQLQYNLHAITSGSLLGSFPVEKLPQFSFFQFIPVCWGKEVYWDSYRPTIKLPGKPLKNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W695</accession>
    <name>A0A084W695_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013710</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W695"/>
    <dbReference type="STRING" id="74873.A0A084W695"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013710-RA">
        <property type="protein sequence ID" value="ASIC013710-PA"/>
        <property type="gene ID" value="ASIC013710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013710"/>
    <dbReference type="OMA" id="FININVM"/>
    <dbReference type="OrthoDB" id="7740749at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="326" mass="36594" checksum="9B83FEAF1287A873" modified="2014-10-29" version="1">MHFACLVLLYLYYIEILLEIKVTPLLQVMYHLENIFNILMVIVALIGPRLYAEQFNGITERLVQVWTRFGQACIDVPLKATEVSTKCLLALYTSHGLIVTVVALTFIEYPLSVLLLGAYQLPYLAVVINVLQFRADLSAIAGTIGCLNDKLERLTQLQSDSADKRAFTKHSQISYITPSSAPYGKGELNRPGHVHAEDIEELSTLHMTLVGLTKDTNGHYGGLLLIIMAASFININVMLLEVYHNFHAQELPVGCVLMLFVHAMLYFSFFVVIAKSNNFVQGENYRTLLLLHEFKCSWDSRQNDAVSSQSHVLFLATIAVSHCILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6I9</accession>
    <name>A0A084W6I9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP012000-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013696</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6I9"/>
    <dbReference type="STRING" id="74873.A0A084W6I9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013696-RA">
        <property type="protein sequence ID" value="ASIC013696-PA"/>
        <property type="gene ID" value="ASIC013696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013696"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009725"/>
    <dbReference type="OMA" id="YERYCFF"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="299" mass="34709" checksum="8B46C416CBA6CCC8" modified="2014-10-29" version="1">MNQNEAKVDGFESRTAQRISQSSSQIIDTFGRQIKVSDSNVAKPVEPSSSEFMEMRNLRRKVNELESRIKDCYDTSSELTERSDEKGYDVIRNPPYQSSRNHLDKYVQDLPISTLNNPWTTIQHRFNGSIDFYRNWNEYKNGFGHQPGEFWIGLEKLYQMTRSKRHELLIVLEDFGGIIKHALYDDFMIGSEDEDYVLKKLGEFWGTVGDSLDPHVGESFSTYDRDNDKRPGKNCAKELQGGWWFISFGSCIACNLNGKYYQQPEVQKLQGLIWFPWHGGFYSLKSTKMMIRRRSVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Q8</accession>
    <name>A0A084W6Q8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013866</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Q8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013866-RA">
        <property type="protein sequence ID" value="ASIC013866-PA"/>
        <property type="gene ID" value="ASIC013866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013866"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="8046" checksum="E870DF977589D27F" modified="2014-10-29" version="1">MTLACETLQCSHTNPPPTRLIGFWVPEVDRLQHHPRIGRTRNASTFALRLRREQRRQPSPKAKDRTTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7B7</accession>
    <name>A0A084W7B7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014090</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021196">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W7B7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014090-RA">
        <property type="protein sequence ID" value="ASIC014090-PA"/>
        <property type="gene ID" value="ASIC014090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014090"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000134"/>
    <dbReference type="OMA" id="YHADGFE"/>
    <dbReference type="OrthoDB" id="6379298at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000471">
        <property type="entry name" value="E-cadherin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784635" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1570"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="277"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="374"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="495"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="624"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="762"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="874"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1347"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1696"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1701"/>
            <end position="1720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1720" mass="194583" checksum="9A9344D3A4E1A865" modified="2014-10-29" version="1">MLIDETARVRWPVLLGVLLLTVHCAAQWGVPMFEAGNDEDISLGAYQENIKQLDVWMLEEKEPGYVLVYINYQGEALPSITLAPGSLGATLEKVTDRWRITITRRQDYEVPAQRYQLILMSIENSQDPYTIAVHLVNILDNEPIMASVNNCEIEELRPSFVSDCLFSVYHADGFEENGIRNSSTNELTFEIDPASGASVHFRFDPSEQTPAEPAYNRLYNLRVLEPLNYEMRALFNFITTVYDLDKTHSFKINTIVKVRNVESRPPRFIRPFATQRIMEKENFSTTVTAIDGDTELNKPICYELKTANSSHQKYFEIGETTGELLVHPIDRDTEENELYPFTITAYKCHNKSFSTTIDSAIILEDKNDCYPEIDVKPIELEFWENTVMELAFEQFVIEDRDLGEHARYEVELWETVGDAGQVLTDSFTIIPSSGYQRATFTINILNPLKLDYEIPARQNFLLHVTAREPIEPTHVRTQPITIHLRNWNDEVPNFDKVDYETSILETIGENELLTKVTVTDRDIDDGIRLTVLGRLSETLQVIALPAEVDETGLPSYAFEIRTKENNIFDYDIAAEVIVQLQAVDQLQSEKGEPLHQIFAQMIVTVIDVNNKPPQITLPRGSMHIEENSVADSAVIIGETDVAEIIGTDPDTEADLQFSIDWSNSYGTKSGIRAKPETYENCFYIREEKLGRQRTIGTIRVNPEFTRLVDHEMYDTLFLTISLVDRNQTILPNDTVAVVAIQIDDVNDNKPVFDEGTLTVVRSVKEQSEQGVTIGNIIAYDIDGPGNNEITYSMVPLNPAHEGWMEIDQTGIIRVAADRKIDCDTPPTDVVRQNVTIADWLWSNFHIFEIVLIDTNNKIPYHEPFPDDGQVYKFEKIKSATPILQVEGKDQDRDTPYHTVSYEINYRNFPQLQRYFEVSGSTGLVSVKENNDPLDRDAGLESIMINVVMVDNAGGYDVQNRNETNIYLTLLDINDHYPELPTLTTEETEISEDAKQGFVIKADFVAVDLDDRQTPNAKIKYYIRQMLPNEEVSLFVLENTNEYNATLKVGVDLKGFYGTKTLTIEACDRGSEYKPILELPEPPVDNCKTRDYELRVNPYNYNTPSISYPARNTQLRLKYESLYNGRPLNDTNGSTIQNFVAIDDDGGIFGDVTFSLRSTNDDEKDHEVFRVDKVDQKTGQLVLENALAVMPYPKNYSVTVIARDGGDKQSEVPIYIVFVDMSGEPAFQEPTFNTDFTENVEGWDERRQLPLAVDPKNVGLPEGAQTNVFYFIDRTYGNASHLFALDPVENVLRLAVLLDREEIPSHELRIVATNNENGPPATIVDSSTALLIVHIKVNDVNDNPPVFQQRFYAAGITTNDRVQKPLFRVYAEDPDEDEVLRYEVVPESMEAVGENLIAGSLPFRLDPDSGELTLTVKVQPNQKGYYQFTVIAFDRDDTHNDTVPAKVYIVSESNRVTFVFLNSVEEIDKPDVRDFLATQLSASYEMECNIDDIDQSLEGRQTGSSTALADVRTHFILDNQAVEATVIQQRSSNRTFVTELKTSLRSLNLYLQDVPPTPEDITEADDTLQTILIVVAAALALLCVILFGAFFVKIRSLNRQLKALSATDFGSIASDMNGKPTRNVPTTNIFSIEGSNPVLNDNEFGRMGGGGVYDDDLSLQSDVSDFRDMDKDLFATTKKESINPTFMDHIRQRSLNPLANGKVDDDHKKVDETEDELSHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7C2</accession>
    <name>A0A084W7C2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP002825-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014095</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021203">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7C2"/>
    <dbReference type="STRING" id="74873.A0A084W7C2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014095-RA">
        <property type="protein sequence ID" value="ASIC014095-PA"/>
        <property type="gene ID" value="ASIC014095"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014095"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000328"/>
    <dbReference type="OMA" id="VMMARIT"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035011">
        <property type="term" value="P:melanotic encapsulation of foreign target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000004">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.10:FF:000001">
        <property type="entry name" value="Phenoloxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014095-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="474" mass="55490" checksum="FD110B2936CB4C06" modified="2014-10-29" version="1">MVFDKKHLLLLLDRPREPVFMGKGRVVFDVPDNYLTDRYRPIGTEIQNRFGENAEERVTVRSIALPDLRIPMSLGRQEQFSLFIPRHRKIAARLIDIFMGMRNVEDLQSCAVFARDRINPYLFNYALSVALLHRKDTHDLDLPTIIEVFPDKYVDSKVFSQIREEATVVPEGMRMPIVIPKDYTASDLDEEHRLWYFREDIGVNLHHWHWHLVYPFDASNRAIVDKDRRGELFYYMHQQLVARYNFERFSNRLQRVKRLNNLREPIGEGYFPKLDSLVASRAWPGRVDSAVLKDLNREADQIKQDVADLERWIDRIYEAIHQGFVVDESGNRIPLDEEKGIDHLGNIIESSILSPNRQLYGDMHNMGHVFISYAHDPDHRHLESFGVMGDVATAMRDPVFYRWHSYIDDIFQEHKNKLTPYSRGQLTFDGISITGITVQPEDGPVNTFQTFWQQSDVDLSRGMDFVPRGNVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7J9</accession>
    <name>A0A084W7J9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">16S rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014196</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7J9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014196-RA">
        <property type="protein sequence ID" value="ASIC014196-PA"/>
        <property type="gene ID" value="ASIC014196"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014196"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014196-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12260" checksum="D04BD09072A5F686" modified="2014-10-29" version="1">MWLKSGPPENGNLVKSFLQKEDRERRRRASALVRAEESSWEERQSSVRLSVRHTVELLPKVVEFMINWQRTSSATTSPLASHLISWKDKQHSSPCCCCISACAASCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7W3</accession>
    <name>A0A084W7W3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004620-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7W3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014295-RA">
        <property type="protein sequence ID" value="ASIC014295-PA"/>
        <property type="gene ID" value="ASIC014295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014295"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011545"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="9137" checksum="FA6BC0B30496AABF" modified="2014-10-29" version="1">MGQRSGFSSSDLAKLNSMYGCKGTSGVSPSTGSTTGNATPQRPVRPSRPAGNNRPGNGAQVASAIVSFIGSIFGEEDSNTTSNSIEGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Y0</accession>
    <name>A0A084W8Y0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014583</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8Y0"/>
    <dbReference type="STRING" id="74873.A0A084W8Y0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014583-RA">
        <property type="protein sequence ID" value="ASIC014583-PA"/>
        <property type="gene ID" value="ASIC014583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014583"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018356"/>
    <dbReference type="OMA" id="GWSILSI"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="316" mass="36770" checksum="9B1E94CFCB138153" modified="2014-10-29" version="1">MNDILKCGSQLIAVYAILVSIVLQRDVHRSVWVKLNIIRGMASKKFVRLFLRLYLCKFYGFVVFCAAIDCYVIFFLWMYTDDTIYYLVVFVLRVFLRLRHLFHMFFIDALKVHLQQLHHGLQDVTSYMQELQSMPKSSPRYKAIYARSIDRLLHLKNVYGQLWDINDGINRTFGWSQICNFTANFIDISCDLYWFYLCTMGKGFEDVTAYFLTIIPSPCLIVLLLHSAESCLREGSSIGTALLNIPLDDDPTLRKIVYRFGLQLAQQRIHLTAHGLFDISYSLLQMIATGITTYMVIFITFSKGIPYEKLEEAMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Z9</accession>
    <name>A0A084W8Z9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003082-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014688</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W8Z9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014688-RA">
        <property type="protein sequence ID" value="ASIC014688-PA"/>
        <property type="gene ID" value="ASIC014688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014688"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005851"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012196"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022625"/>
    <dbReference type="OMA" id="HQVEDEN"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784663" evidence="7">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="473" mass="53520" checksum="980CBE134B8819F3" modified="2014-10-29" version="1">MKLVVVICLLLNLVVSFCLGEFLIDESDGQLSTVALVKKYGYRIRQYTVTTNDGYQLMVHRMQRKRGYDPQLLPVLIVHGLFGSSADWVLIGPKNGLGYLLADAGYDVWLANTRGNRYSRQHLTLAPEDPEFWNFSWHEKGMHDLPAMIDFILNEPTTKARNVQQIYYIGYSEGGSVYYVLTSSLPQYNAKIRLAHTLAPAVLLNDMRSPLVLSLSENTASLLPLVRGIRLVELFPWSETQSGFLRTMCPPSVANNQCVSLMANIFGPNPASLDLKVVQAMFGHFPSGAAFKEVEHYNQIIFSGIFRPFLEENKGSLSEPYNLSASSAPVYIYYGINDWLVHPRNIPRFAAELPNVRERLTVGGKXXXXXXXXGRFQQFDFGYAKDNLIHYGSETPPVYNLTLVTVPVVIYYGLNDWMIHPQNVIRLKNELVNIVSINAVEDPDFNHLDFILAKQVRSLVYEKILNDLNQLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Q8</accession>
    <name>A0A084W9Q8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylcholine transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">StAR-related lipid transfer protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00014965</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with ACOT13/THEM2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Q8"/>
    <dbReference type="STRING" id="74873.A0A084W9Q8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014965-RA">
        <property type="protein sequence ID" value="ASIC014965-PA"/>
        <property type="gene ID" value="ASIC014965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014965"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022868"/>
    <dbReference type="OMA" id="NQLCERC"/>
    <dbReference type="OrthoDB" id="1295045at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000017">
        <property type="entry name" value="Phosphatidylcholine transfer protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="96"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="463" mass="54561" checksum="E37C66CB74C421E7" modified="2014-10-29" version="1">MAMKLFPNSSLALRNFNKYLRKNVKDQSASILRLWATQCEFLFAQQLRRSQQIFAHYAKIWEERALRELLRRVRGQVQRQAKGFIVSSAALLSFDWERERIELDSVQEHLDDFQFLERLQTETIFCKQCEKRRLFDSRVDGISYCSCPRNVTEMLSVEQNAYTAWEPYIEQERMITWRRMYVEYPDVTAEDFLHVQIDVEYRKKWDNTAVNLEVIDEDSAKGSNSHVIYWEALWPKLFANRDYVYNRRFFVDRNRRVIMIVNKSVEHPKCPAKAHTQRVHEYWSYMVIKPTTSFNKPGVSFVLTYFDNPGLSIPKYITTWVAKKQMPDFLQQLHQATVNYAKAKKQNETRIIQFWDKHKDPGFEYPPDTLLGYSAEDFTEAQKQEEESSLQQANNNPSVGSTNAALETVPGGAKSKLSQQLFTDTQSKPSEPTTEPTDCPPEECTPKKKSSWWSYLYSYIYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAM8</accession>
    <name>A0A084WAM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015300</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015300-RA">
        <property type="protein sequence ID" value="ASIC015300-PA"/>
        <property type="gene ID" value="ASIC015300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015300"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8565" checksum="94DE6AC79F1C5FCB" modified="2014-10-29" version="1">MADHRGIPSFSERCEVRDGNVESRIPDPRWEGRLFFEFFNFRGLFVSGRGGMGVAGEGAIGLSSSLAQTSWRRRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAP1</accession>
    <name>A0A084WAP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010904-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015314</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAP1"/>
    <dbReference type="STRING" id="74873.A0A084WAP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015314-RA">
        <property type="protein sequence ID" value="ASIC015314-PA"/>
        <property type="gene ID" value="ASIC015314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015314"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020499"/>
    <dbReference type="OMA" id="IAEPAYT"/>
    <dbReference type="OrthoDB" id="7735704at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784602" evidence="1">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="24780" checksum="43BAE5F845BD7E17" modified="2014-10-29" version="1">MAFKFVLLVASIACASAGYIPKDHSYSSSLSYSTIHNNVAPVVSKTIIQEPQLYHGYAQGAPSVVVSKPLALTEALPVSYSAPQSIYQAPAYVKNFEYAPKPLSYAPIGKTIIGEPSYGKTIIAEPTYGKTIIAEPTYGKTIISEPSYGKAIIAEPSYGKTIIAEPAYTKTIVSEPIYTKNVYAEPIYQSKSLIAEPVYGKSILAQPAPIYGGKVLSYAPNVGYGGIASHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAP7</accession>
    <name>A0A084WAP7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015321</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022232">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAP7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015321-RA">
        <property type="protein sequence ID" value="ASIC015321-PA"/>
        <property type="gene ID" value="ASIC015321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015321"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006789"/>
    <dbReference type="OrthoDB" id="7742239at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784606" evidence="2">
        <location>
            <begin position="18"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="645" mass="67517" checksum="D92664BEDB27E723" modified="2014-10-29" version="1">MNKIITSFVACLALARAGYIEHYQGATSFTSFDLKSTGTDGGSKLYINKPTLTYGAATLKGSTDHAAHSKVVTYETKPVISTVYTAPVTKTVTYASAPIQYASNHHYVAHGHGSECALKEQKLVTPVHSTVSLVAPGSTSYLKPVYSLSSSKEHQHSAAQTVSQSYPSIQAQYTKPVYGAQTPSLNSGSSTISHSISHNHQATGSSGLYVPSQSFGSYGTLSSSSALKESSSSGYGQINTFGAYQGFLKPAPINEHSIDVAPPKLISAQQSIVHGEPSSYTNYLSHTVPVVTSHKIIPLKATHSLSQTHSSNTGVWKDVNSGYASTHQYNAGAIPIKTSQYYVAPAVGLHASSASSSTTGTPVVAHQHSSGSGYSSTAGTSAWKESVHGPASFPIKPSQYYVAPVVSNLHSSAASSSTSGGSVWKESTYGSALVKPSQYYVAPAVPSIHAISGSSSTAANSAWKGSSYGATSTSTHIQHGAAKEGSKQNGHSYTTTHTHAAPVIVQTQQYLPSKITIAAPKTSETFSSTASLSHASSSTEAKEPPREYLPPREYLPPTQQNKGSSGHVITSGSGSTSYEVPLKLTSTGQQAGFLQTNSHVSTQHTSHGTAAIVSPLHVTVQKAPVLVSIPSTDCSQHQQLQHQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAW3</accession>
    <name>A0A084WAW3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nav1.4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015599</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015599-RA">
        <property type="protein sequence ID" value="ASIC015599-PA"/>
        <property type="gene ID" value="ASIC015599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015599"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8758" checksum="0E3814C940B53E2E" modified="2014-10-29" version="1">MACNSHVAEGEDEVVDDEDLGLTDAESLRRETCIESDSSRSVPQTVDEGLGVTESINTGSAKCQSGTLVKCLLRRRHYSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCB1</accession>
    <name>A0A084WCB1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022650">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC015956-RA">
        <property type="protein sequence ID" value="ASIC015956-PA"/>
        <property type="gene ID" value="ASIC015956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015956"/>
    <dbReference type="OMA" id="PWRILKE"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="13816" checksum="FF842F00CAE292F4" modified="2014-10-29" version="1">MEIVSNFQQKQNKREGXXXXXXXSASAADKKKKVAAKKPAGEKKVKKVTKKAEGAAAKKPKAAATAAKKPKAATAAKKPKAADAGKKAAKKPAAPKQKSTKPSKTPAAKPKAPKPKKAAAPAKKAAAPKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCN8</accession>
    <name>A0A084WCN8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED9</name>
        <name evidence="10" type="ORF">ZHAS_00016092</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCN8"/>
    <dbReference type="STRING" id="74873.A0A084WCN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016092-RA">
        <property type="protein sequence ID" value="ASIC016092-PA"/>
        <property type="gene ID" value="ASIC016092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016092"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002364"/>
    <dbReference type="OMA" id="ESQDCNH"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB47982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12778" checksum="89C74070B9D579DF" modified="2014-10-29" version="1">MDVVDIKPQIANIPEPKIQPVEIEILPVVYDIIRSVEKDPIDNTAKQKESAECSQKVLELQRSLDAARATIRKLHGIEYSKEEQLRRLESLRKQLALKQQLIKKYKNVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCT2</accession>
    <name>A0A084WCT2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016144</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016144-RA">
        <property type="protein sequence ID" value="ASIC016144-PA"/>
        <property type="gene ID" value="ASIC016144"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016144"/>
    <dbReference type="OMA" id="SPMERMY"/>
    <dbReference type="OrthoDB" id="7742652at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016144-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="477" mass="53375" checksum="5520135E4C42675E" modified="2014-10-29" version="1">MAYNRMQFMQWMKNFHTRQRQLEAKATRSQMARRVIVVRKRAPPVVVPRPAVTEQSIQCDLPIVLPPEPPKTAVTVGTQWTRQKQTVTKAKRKPAKTRSTGTQISSKISTDLQPAAGKTSSNATTATTRKGPMRQTKLHSYAEGGKDRPQRQPAPPRRQQQQRKCSPKLPVKEVSPPVPSTSKNPPAKKKSPSPKQGAAKNSKNSKQSKEPSPEIHVAETPSDTEVEEKKHFPYRTQPRYPSVCSKSTETSFLTPTKVRDIVPEPSDGMREQQPRHQTQLVSPMERMYVGPVEPPLSRTIERPNYGPFLVPLGTTGEEETISPTPPNIMYVNRPERRMLVRSTVPTASNNTNVRGTGLVREKYPEVSIISSQQLYSQIGLAVEKALKNKTIPPLESMYGKPFIEVFNGVDSALEDNDSEEDKRVTDDRRAGLVCSSANNDRGQQQANRTVAPPFHNDRSPSLSPIVYRDDDSADDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCT3</accession>
    <name>A0A084WCT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016145</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016145-RA">
        <property type="protein sequence ID" value="ASIC016145-PA"/>
        <property type="gene ID" value="ASIC016145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016145"/>
    <dbReference type="OrthoDB" id="7742652at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016145-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="285" mass="30670" checksum="785ED3A690E51751" modified="2014-10-29" version="1">MAHNESATTMMVPEKLNPKVMASPAPKTASKRSATSEGQWPECSSTPTSSRKKAFLEPGGGTPLSVVSLNASALDRSGSSSSRSRNQRSSTLRITRGIQTIAPETVNRYCTARISRRTASVPVQTDSVYVLSSPPKKILRADATCQTAEPAVQEACVGTSQQVELPSKQSVDSGCQTMALEDQSITVHTTSTPKHSSTEQLKNDNEESSPSSIGTLLNGLERVFGFDVSSNEKQPDDSKEATKGIEKQTACDQQQHLLQESFVNETSKTVATKLDKKCPSYWSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDS0</accession>
    <name>A0A084WDS0_ANOSI</name>
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        <submittedName>
            <fullName evidence="4">AGAP005018-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016484</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDS0"/>
    <dbReference type="STRING" id="74873.A0A084WDS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016484-RA">
        <property type="protein sequence ID" value="ASIC016484-PA"/>
        <property type="gene ID" value="ASIC016484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016484"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015950"/>
    <dbReference type="OMA" id="NDFSCNG"/>
    <dbReference type="OrthoDB" id="538216at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF13">
        <property type="entry name" value="LD36653P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="280" mass="30664" checksum="4ED3C80B7A73EBFC" modified="2014-10-29" version="1">MKRQRVKAGAGSSSHVYVEDPYSVDGYDVPLAQQRTAPIERFLEAQILPGDTLQAIALRFNCSIPQLKKLNKIDKDNEIYARNVIRVPLTPHSVLLETLPRVHTSGNSSPKNITTPNPTAGGGIVPGDTKATLDEKLILAAVSNASIQPSSGAVTQFPRKSSGKHRDPTRARSDEIALDELEDGDNDDHLSSEPLLISGEYDDSLPQPRALRLPANDFSCNGSDCDISWICLLVFILALCFAIPLIYVVYVAEHIEKYHHDSFSGNPSVHHINKSHSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE21</accession>
    <name>A0A084WE21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016449</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016449-RA">
        <property type="protein sequence ID" value="ASIC016449-PA"/>
        <property type="gene ID" value="ASIC016449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016449"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9626" checksum="50E57B2A0367FFE2" modified="2014-10-29" version="1">MDGRRSPPMEKSIQKVRPITDGLAFRGRTRDGHNPLNGFAKFSVFSHGDEFPFENSPAHCAKCGRGRVGISITPKKSQKEKSQLPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF05</accession>
    <name>A0A084WF05_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol kinase 5</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP:glycerol 3-phosphotransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00016810</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF05"/>
    <dbReference type="STRING" id="74873.A0A084WF05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016810-RA">
        <property type="protein sequence ID" value="ASIC016810-PA"/>
        <property type="gene ID" value="ASIC016810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016810"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014109"/>
    <dbReference type="OMA" id="TFLTWNH"/>
    <dbReference type="OrthoDB" id="6278781at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07793">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000102">
        <property type="entry name" value="Putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000104">
        <property type="entry name" value="putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037444">
        <property type="entry name" value="GK5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="15">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="16">
        <location>
            <begin position="289"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="537" mass="59820" checksum="468A0250BA799586" modified="2014-10-29" version="1">MEETPHYIATLDIGTTTIRCFIYAARTNGDPVSIGTAYDHVELLYPAPGRVEINPEKLWTSVLQTIAKATTDAELKINQLSCLAISTQRNSFTCWNRKSGQVYHNFITWKDLRADQLVNEWNKSFTLRLMKFGASCLYFFTRSNRFLAGSVIKLMNPQVTMRLSWIIHNNTVLQDDIKTGDVLYGTIDSWLLYRLRQGTDRSREVHHISDVTNCTSAGFYDPFAQQWAGWALSLFSIKKELLPTVVDNSHDFGYVHESLLGAKIKIAASISDQSASLWGNCCFNRGDVKITMGTGSFLNVNTGSKCLASVHGLYPLIGYKLRDASGMDITYLMEGASNDSGSIIEWAMNVGLFDDPAESAGMAMSVPDSDGVLFVPAFSGLGPPIRDDSAGSGFIGIKPSTRKEHMVRAVLESLAFRVSLLYDCALNETGFSFNCIKVDGGVSRNDFICQTLSNLTNVKVERGEVVDSTAMGAMFMAGLNIGIWCSKSQLVNLRKVEKTFTPDPVHRAIQLRQIRAWQKAVDRFKKWYMLEDIKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGB3</accession>
    <name>A0A084WGB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017367</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017367-RA">
        <property type="protein sequence ID" value="ASIC017367-PA"/>
        <property type="gene ID" value="ASIC017367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017367"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8314" checksum="A678E1F0D542D9C9" modified="2014-10-29" version="1">MGTPEAGSGTKETETDWITFTTLPKKTKTLTDDEVAFLHWVCCGMSDPEATVTIFIRSACRGSVPVSTSAEAQNVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGZ4</accession>
    <name>A0A084WGZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Porphobilinogen deaminase isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017689</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017689-RA">
        <property type="protein sequence ID" value="ASIC017689-PA"/>
        <property type="gene ID" value="ASIC017689"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017689"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017689-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17264" checksum="D663BDDA5C258406" modified="2014-10-29" version="1">MQQQGMISHGIDAGIGGIDLGDGASKCPQAADEPVNRRKRCAIDQRSVERILRGPRLLLLLLLLPLFSLAAICKRIAPVDCALINYVNYGPLVKSLPQHMLERCWRDTTTTAAGASQITNTLDNRRQNNPVCDFPPASLALPCRDTDIVERQKRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIM6</accession>
    <name>A0A084WIM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018120</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018120-RA">
        <property type="protein sequence ID" value="ASIC018120-PA"/>
        <property type="gene ID" value="ASIC018120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018120"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12844" checksum="10D347D980FEEA12" modified="2014-10-29" version="1">MYSLSESNYIFDPFDTSGSVFVDDHDDDDVFFYSPLGISRCASSASATSLSPGTRSRFGPRRCSHIHLILLRLRDVCKLPVFGSETLITADDDDDRIVDMLGFGRRSEEGEGEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJB2</accession>
    <name>A0A084WJB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004873-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018518</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ATLV01024007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WJB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018518-RA">
        <property type="protein sequence ID" value="ASIC018518-PA"/>
        <property type="gene ID" value="ASIC018518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018518"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019175"/>
    <dbReference type="OMA" id="HMVMESQ"/>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cortical actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FH1/FH2 domain-containing protein 3 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="FH2_Formin"/>
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        <property type="entry name" value="FH2_Formin_sf"/>
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        <property type="entry name" value="FH3_FHOD1-3-like"/>
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        <property type="entry name" value="FHOD1_GBD_N"/>
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        <property type="entry name" value="GBD/FH3_dom"/>
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        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="843"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="716"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1250"/>
            <end position="1384"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="421"/>
            <end position="434"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="459"/>
            <end position="469"/>
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            <begin position="601"/>
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            <end position="729"/>
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            <begin position="736"/>
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            <begin position="1297"/>
            <end position="1308"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB50306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1384" mass="153509" checksum="FFAE4455017AFF28" modified="2014-10-29" version="1">MVEGLDDAALQVYKDGDYGAYLDLESSLAEQAEDIEGLNSNRKNSLVVRTQLSVRVHSIIEKLLSSEGRELRRVLFSLKQIFQEDKDLVHGFVAHGGLNCLVQIGSEADQNYQNYILRALGQVMLYVDGMNGVMKHSPTIQWLYSLIASRYRLVVKTALKLLLVFVEYCEGNCYLLVSGIRFVDTARGVVPWNNIMRLLKDYENADTELLIYATSLINKTLSGLSDQDSFYDESDFLEQQGMEGIIQRYMSRPGTDLDLLDQLQLYESVLRFEDGECDGMRIPDNTVRKTLRYRSSGNDTTDRRKSRRHSTGTAPPQPTVPSVHIPAAPTCAPPPPPPPPLPPYPMYSAAPSGPPPPPPPPLPPPVAPVQLYGGLQLPTQQTQDDDSSSSGHSGDHLPGSGYHDPSRDTTGVTPGLRRRRERAERQKSFMREQQELSQFQNGSAPGGEDANAANGYNHHGPRNGTHRRSNGLTNGCAPNGLLTSSSIPPPTILEEDKLQLRLNGTLTSSVILHKQSTNISEHGTNGNCTAGNSIAPPGESVVEKRNSRNLLLTSKHSNGVASLSNGTGSAVHDRYKVDLNGNNVRGGRSGLLAEQDDENKSPNIKSQMAQSVGYGKQLVVSNGKESSESTYLRRSAQVGYERTNGSMNGTHVEPKSQDLQTVQESDNEDKKLILQLKKDHTVKDLTQKLSCLPLSPQEEKPQSRIGDMTGLISKAKEGLAKSKSNKDISRSPSVDNDIKKLANGDPKKSENELHWEEIVKNMTRKLSLCDLDFTDLTSDDDKDLLAPRGFGGAVPPPPPPGGMMLNGGMPPPPSMMRPPPTNLVPLPGHLVNGNGMAQQNSADTAAIKKNKKTVKLFWKEVRDDMIPALVQRTIWDELPEAVVDTQKLEHLFESRAKDLMTKKQQELNKNKEIIVLDHKRSNAINIAMTKLPPPRAIKAAILKMDSTVVTREGIDKLLNMLPSDEERCKIQEAQMLNPELPLGTAEQFLLTLSSISELGARLKLWAFKLDFENIEKEIAEPLMDLKQGIELLKSNLTFKCILSTLLNIGIFLNGAPVKGFQIDYLAKVPEVKDTVHKHSLLHHLCHMVMESQANTTDLYSEIGPITRASKADFNELAHNITYLETECKASWDRLKLISKHDTAPHLKQKLIDFLADCAERIIILDIVHRRVLNRYRKFLLWLGVPQLRIAESRPNEFCRIVSEFALEYRTTRERVQQQIEKKANHRERNKTRGKLIVDVAKFKSQEDRADDELRTLLGTPTKGPGGDEVEMSGTLTWRRRRGDAAASPVTLMHSHPTVGTSPAHNTPGSAGGGGGGGRDESFTDADDEILESLVKTATKTATPRPMQRERKRTRQADRKSLRRTLRNGLSEEEKQHVASLIKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJK7</accession>
    <name>A0A084WJK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005743-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018427</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024038">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJK7"/>
    <dbReference type="STRING" id="74873.A0A084WJK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018427-RA">
        <property type="protein sequence ID" value="ASIC018427-PA"/>
        <property type="gene ID" value="ASIC018427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018427"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019851"/>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="6">
        <location>
            <begin position="312"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="702" mass="79951" checksum="3E71E8769DABD7B1" modified="2014-10-29" version="1">MNRGRFNHGKRRSGPFNKGSQYGGRDRQPKTNAVRTSFISEKDIHCTEYVSKLEGFQGVLKSRFSDFHVNEIDADGEEAILTETALPKPPTVEADAATDANDQPIDPNEELIRLITSENLQRIQEIVDGKGDEPAVEVDVTELSKQDRTTIHTRVKALFGSAVVGSTLTRDERKWIRFAKYDKATVRDRREKWVWPHPYTYFMLYKENLDTIQATLQLSQKLHCAPSVLTTAGTKDRRAKTTQWMCIKTREPSKIAAAARGLPNVTVGNFTFKPTTLKLGMLQGNRFRIALRHVTVEDQIINASMEHLREKGFINYYGLQRFGNCASVPTYRIGIELLKGSWKEACDLILHPREDEPPYMQEMRSVWQKTHNAAEALKKVRSTNKSVEAQLLHWLANHGNKDYIGAIEHLPRNVRLLYMHAYQSLIWNRVASRRIREYGLEPRVGDLVYLDKTVEATAQQEASAVAVEEDLTNLEVYEAQPGEDDQQLNEEDENVSSDPSPFKSLVRPLTADDIASGRYTMFDIVLSLPGHDITYPDNECARWYEEALGEESLSSEKLKRKSKKHSLTGAYRKLFVRPERMEWKIVHYEKPTDTLILSDVEKMKKVPEPPFATWAEKENSLKAVLMDFRLPPSTYATMALREILKTDTSASNQRTLEKSGQENTADSSVATEQDAKKEASEQQPDDEPVCKIAKISPEKIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJP5</accession>
    <name>A0A084WJP5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclin-dependent kinase 5 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00018469</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01024045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJP5"/>
    <dbReference type="STRING" id="74873.A0A084WJP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018469-RA">
        <property type="protein sequence ID" value="ASIC018469-PA"/>
        <property type="gene ID" value="ASIC018469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018469"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021527"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07839">
        <property type="entry name" value="STKc_CDK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000184">
        <property type="entry name" value="cyclin-dependent kinase 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB50439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="32933" checksum="74921649BD8F1D91" modified="2014-10-29" version="1">MQKYEKLEKIGEGTYGTVFKGKNRDTLEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLYDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDPDVVKSFMYQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCIFAELANAGRPLFPGSDVDDQLKRIFKLLGTPTEDTWPGITQLSDYKPFPLYPPTTSWSQVVPRLNSKGRDLLQKLLVCRPLLRLSAEQAMGHPYFTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL46</accession>
    <name>A0A084WL46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">CRISPR-associated protein Cas2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018979</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018979-RA">
        <property type="protein sequence ID" value="ASIC018979-PA"/>
        <property type="gene ID" value="ASIC018979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018979"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7340" checksum="20ED17875B6EF419" modified="2014-10-29" version="1">MSAGGKVARNVEIGRVRADIQHDVQAAGPLRRADVPQQPQSSTFGDESHDDDRVPPDDDCVSLRWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLM3</accession>
    <name>A0A084WLM3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP006703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00019176</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLM3"/>
    <dbReference type="STRING" id="74873.A0A084WLM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019176-RA">
        <property type="protein sequence ID" value="ASIC019176-PA"/>
        <property type="gene ID" value="ASIC019176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019176"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004637"/>
    <dbReference type="OMA" id="WIFCENS"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB51117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019176-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="525" mass="60002" checksum="994A060BCB9E09E4" modified="2014-10-29" version="1">MAHLGTVAGVLRLAAMTFLQTFWVFCENSSLHGLRYIGRSNATRANLLLRFVWSLVALVSLGFTLMLASSAWDQFRSNPTLTTIETTTYPVSLIPFPSVTLCNINKINSAKAMEMSQMLINLGMAENDTIDLIASLQRLNDYRPIDERMLQMELFLYNKGYRVEQLAYELAPPCETMVALCFWLMEPVPCAQLFRRTKIFAGYCCSFNADGFLEPADSRRPNHTAKSIHVNGIGKGEGLTVVVDIGEANYTPSHRFTYGIEVFIHRSYDFPDYSDYTTVIQRGWETDVSVLPTIVSASPSLRSVPIERRGCAFSDEGNMSTTLPYTYSNCMNECEQRYVAEVCKCIPLFREIVELQVKFKVPICGFRDIGCLQKIKRTYHRTPEFNFTSHGLLHVHFRSTNCLKYRREPFVTWQTLVATFGGIFGLCMGGSILSLVEMIYHFGITPFIVYQELKEKLLLRCKPNPLPVTHVPFPRRPPMGHFRRNEVIARAMMEDGSTPKGFDKKKYINTPYWRKSYVDELKIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMA1</accession>
    <name>A0A084WMA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019404</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019404-RA">
        <property type="protein sequence ID" value="ASIC019404-PA"/>
        <property type="gene ID" value="ASIC019404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019404"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="18042" checksum="FB14868C532DE9E1" modified="2014-10-29" version="1">MTPARGQSVRTIISSTMFYRRTHRLCRQHFNGQAKGFFPGDGKMEKFRLAAVGASQSVVDHFTVDRVCKSDSSTVPFPFHHSHHRSLVKMDPNLPRKAYTRWLISNLTPTGMLRITISNFCSVTPAHATNSERMECILSIALRRSVESFRLLPEYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMT4</accession>
    <name>A0A084WMT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006823-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00019590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMT4"/>
    <dbReference type="STRING" id="74873.A0A084WMT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019590-RA">
        <property type="protein sequence ID" value="ASIC019590-PA"/>
        <property type="gene ID" value="ASIC019590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019590"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001538"/>
    <dbReference type="OMA" id="NPFAQEV"/>
    <dbReference type="OrthoDB" id="7760340at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784946" evidence="3">
        <location>
            <begin position="17"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="855" mass="93603" checksum="49DCF6D515C6602F" modified="2014-10-29" version="1">MIWVDDIFGLFHYCVGFALCCHVNKSAVVEDGAAAKDGTDYGGHQQQPRNEDVQCKPDDAAPRESRVATDFHRPAQSVPVAMLRGGKSLPNGGGPDAVDEVVVGKPPSRERVNSTSHYSTEKSGSSGYYSTNLYSTGGSLVDEHIYCEPIDRCPRTQGLDVGKDRNDRQGLPALKRQPPVGGSEESSGVAPANCDRKRRGKNDQELSELQRNVRGLEQYYYPSSLASPAAPVQISVLRASVVQQQQQQQSLGVGPGVQECGGQDLSCAEDSQQQQAGDHPDQSEQPLSVIMEGIDGQIPRPIWPLDTDDSLMDINLESFRMANHSSQNLIGFESPTLSSLTDNEQYAHGANGGAGEGTQGPGEQGHVRKKSQYEEYLEFHNTRNILEQIRGKLNTLLEQRNDQQQEQPSQRVPNSGNPFANSTIVTPPASGETELEKNIAILKADLDGYLRTMNQKNENEIKRFCRGMSREPKVVAVQNAVEQRNRSRSGSIMSLEHDYELLDRSGGAGGLPYGSIVSVGSESQLPYYQVMPPMDGEGTRHYPTGRPPAALPTAAALVLNRRSPPNPFAQEVRSCQVFQHGPGSTSLAGSHSLCCQQRYLNSDEIRICNRYGGCDRAGGGHANVAIDMPDDGEDNDSDDESFVGVSAGNRGSVSIGMPPMDAGSSADGGDVRRGSRVKIKSDASGDGDGGKGGDSASDSSAGRAAMAHCDFSQLQRNITLERIILMESLGKGRTGQFGDKEKMLLEWHQNKPSCWELYYGANREEQKPHQTLIRKMKLGRKNTVCISYPSTRPESDFTLDVPRAEQLRLKMKKEKQFRSRCRWFFYFLSVVFFLLSVMVVSLILTRGKRMFGSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN25</accession>
    <name>A0A084WN25_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007384-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019693</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WN25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019693-RA">
        <property type="protein sequence ID" value="ASIC019693-PA"/>
        <property type="gene ID" value="ASIC019693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019693"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019741"/>
    <dbReference type="OMA" id="ILHELHY"/>
    <dbReference type="OrthoDB" id="2151624at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="816" mass="89058" checksum="2FFAC10BC927EDA6" modified="2014-10-29" version="1">MTAGIAGGGSSGKLTRREALSTTSQPPTSTSAYQSPSSGTQQQSFSIRNSSSTLSTNTKPTSGGTVVGSTINQRQDETSRDAKDAFSAWSTAKFVNKPNYDRKALDKRFGGTLTTPDLSDWQCPSVSSSDNLECSCDLPHTLRCSGDLHGLEVIADSLRRSPYSVSLLDCTLKNVTTISDANIFQNVSLQGLVISSGEIKRVHRLAFAGIRLPLQALGLPNNALASVPMQSLGSVSQLDRLDLSFNKIKSLQNTDFIAVPKLSYLELSGNQISLISAKSLAPLKSLLHLKLNGNRLGESPASLRALEACVALKELDLHANGIKGPLRNTTLPAIRGLEILYLNKNSISSVHNGALEAYPYLQMLSLRNNQIDVLQDHAFSGLASLQVLDLGHNGIVTISGASLKHLPRLIILDLTHNFLRVLTADVVAPLPALKELRLDGNDISLIAESALVNATQLHSLSLENNPLVCDCTMKPFLQWLAGSRIASQDILGAICATPPHLEGAGLLQLAPDTLSCDNGKVQGGDASSDEDTFKTIEVMLKLKNNASYVRDIGQEVKLRGVNFTDESDVFLYWLLGTDDYSCRFVYVFHDDDPETILFNSEVSCVVKPEEQTTMEYIYSTKLTGAYDLQSDASYKFCLILKEDISKDEYLGACEVATLPPPHLNPTKRKSIKKELQISTRQTNESDISDLDRMANSFRHDDQNRDELLKDNGNDGDDEEDQDGDGSDGDEEEDTTDESDGEIGEYDGTDEMLPGHIRDGSDFRRXXXXXXXRGTGGKNRGLPSMSTCYTVDDRRRTAHQDVESRSRYFKLQATTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNB0</accession>
    <name>A0A084WNB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007485-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNB0"/>
    <dbReference type="STRING" id="74873.A0A084WNB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019791-RA">
        <property type="protein sequence ID" value="ASIC019791-PA"/>
        <property type="gene ID" value="ASIC019791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019791"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012416"/>
    <dbReference type="OMA" id="ETFRKPH"/>
    <dbReference type="OrthoDB" id="5804096at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785176" evidence="8">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB51704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="186" mass="20908" checksum="2BAEE4D7459F5CC9" modified="2014-10-29" version="1">MPIVRLPHLLTPTLLVLVLMLLVPTSSDETDCNTLRMGQFICPNPSLRQIDPKTQQLRGCTRENKARVWCIAAEGIICSETKNNSFTRELPCKWTNGYHFDTALLLSVFLGMFGADRFYLGYPALGLLKFCTLGFMFLGQLVDVILIATQVVGPADGSAYIIPYYGPVITVVRSDNWTYRLPQDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNJ9</accession>
    <name>A0A084WNJ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3 8">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00019946</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3 8"/>
    <dbReference type="EMBL" id="ATLV01024618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNJ9"/>
    <dbReference type="STRING" id="74873.A0A084WNJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019946-RA">
        <property type="protein sequence ID" value="ASIC019946-PA"/>
        <property type="gene ID" value="ASIC019946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019946"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002446"/>
    <dbReference type="OMA" id="HVHINPI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="389" mass="44620" checksum="703958CEE109D072" modified="2014-10-29" version="1">MLGTQSTARNEQTTSADNKCDVDESELQRQREGQQAEETCYDLSHFRTVRVLNNNSTHKSVALLGHFTNLSTEQYAIVVLEKRAFTEAQVTTAAPVTDGRNTPTQRENCAVVSESENESPVADVEKSSSRTFFTSSSRLETEFINDIYGNFTCTVDPALNRLKVTIVYPAAEKHIVKYSVQKRYIIEETADLYKRITLPHLEQGQLSLEWLYNVLEHRKEKERIVFEDPCDENGFILLPDLKWDGKTVEQLYLLALVRRRDIRSLRDLTTSHLPLLRNVQSRGIAAIKERYGIGASELRIYLHYHPTFYHLHMHFTYLRHDPPGITCEKAHLLSTVISNIELLPDYYQRATLSYTLKETDKLYEKFVAEAEPSEPAAKRAKVDSSDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP64</accession>
    <name>A0A084WP64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP006440-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020198</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024936">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024937">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024938">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525365">
        <property type="protein sequence ID" value="KFB52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP64"/>
    <dbReference type="STRING" id="74873.A0A084WP64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020198-RA">
        <property type="protein sequence ID" value="ASIC020198-PA"/>
        <property type="gene ID" value="ASIC020198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020198"/>
    <dbReference type="OrthoDB" id="10348448at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020198-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="651" mass="75802" checksum="F46CD09C131AD618" modified="2014-10-29" version="1">MGDEFVDLSHRASVDRLFPDRLSNLSGSPYKVACCEDPALSYLNGKKKLVGLDIDFIDIIAKHQRTSVEYAYTPVPHKVFEPWYDRTIDFATYRMISRGTTKLLPFSALYFPNQYRWCVAVPKRYKRIIHEQVIWPFTVDLWMLMSGTVVFFFIYETMLQKLFSSRYPSVYSVINTPITIMRIMLLFLLSEYYTAILTSNLGLSRVPNYPKNLRELMKSNMPILTMQPYILEYIAEAPELASKIVEWSKTIRYDPFQYALVQMCDNFPYTIALATKNLGKELTRHHYHLIDEPIRTAIGYSPFEKTSPKVHRFQRYVSRLAEAGIWQYLIRKWNAIYSTSFHFYVDSDMASSLLYLNHFVPVFIVASYIYVLAIIIWPYTPSLWLLITSISACFIVYHLLLKDLLLKYFPNIFPIINTPLHILRILLLFLLTEYYTANLTAILGVSQVSVYPKTLDEFARSPIPLIMSAPDDYQYVRENPEVRAKTIEWNFSKTYDPAGMALIQLCDLFPYTIDHTTSLMGKRFGYRHYHLIGEPIVRTIVISPFLKTSPLMARFQKFVCRLNEAGIWDHLVRKWVALSRWPNAEDVDLADGKQGMFTQRSTILQLEHFTPVFLLAGYVYLVAVVVFLLEIAVHRILRRFNSAGRGFVAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP83</accession>
    <name>A0A084WP83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP002195-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00020208</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525366">
        <property type="protein sequence ID" value="KFB52027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP83"/>
    <dbReference type="STRING" id="74873.A0A084WP83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020208-RA">
        <property type="protein sequence ID" value="ASIC020208-PA"/>
        <property type="gene ID" value="ASIC020208"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020208"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024480"/>
    <dbReference type="OMA" id="AGVEFMK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11057">
        <property type="entry name" value="CYP313-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB52027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020208-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="503" mass="57593" checksum="55026C480409DF63" modified="2014-10-29" version="1">MLQLMLLYVCGLLALAMVVCVRWKRRKLYAAAASMDGPPCLPLLGHVYLIFGKRCGEDILQVLDRFAPRYKSPIGMWMGPKLIVGIKDNPEYFQTVLNSPHLLNKMEQYNFFRIVNGLFAAPDHMWKNERKLLNRSFSPMMLASFVDTFNDKDFIMVDNLRKLVGKGEVDLHLPIAKCTIDSIFGTAFGKDLNTQGHDEADEYLHSLDTFFSLVFKRMLNVERYPERLYRLTKDFETETSCLKVIRDMSHDLMQQLKVNSQQTKTQPEKADSCERKPNLNFAESLFDIAEHNPRWNEGNIRDHIDTMIVAGHDTTATTMSNLLLMLAIHPEVQEAVYQEVMSICPDKSKPVTTEEANGLVYTEMVCKETMRLFPVGPIIGRTCTADVKLDEKHTIPKGCCVALGIYQLHRDPSIWGPEAEKFNPDHFLPEKVAERHPYAYLPFSGGPRNCIGIRYAWLSMKILIAHLVRNYRFSTSLKMEDLKVKFAIILRITNGCIVSIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPI7</accession>
    <name>A0A084WPI7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000533-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020454</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025080">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPI7"/>
    <dbReference type="STRING" id="74873.A0A084WPI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020454-RA">
        <property type="protein sequence ID" value="ASIC020454-PA"/>
        <property type="gene ID" value="ASIC020454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020454"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007356"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="295" mass="28936" checksum="57F79E5513EF1377" modified="2014-10-29" version="1">MLVCLQVRRSLTELLQQYNSPAIGTNVSVGTREAVLMGGAPLGGGSSSGSTAPPGIVSVGQKITPVTYSISAIKTSIVTTSVASGTSKVKVISTGHQQGSPAGGAPYTLQATARAPPGTTVLKAGAGGGRVRTNGGGSVAGGAFLGRTNRPVPVGESITIRPIGSSFGSTSSATTISYLPAGAPAMASTSSTLLSTASVALFPAATSSFGVSPGTTAPITSWSSLGNIFGSNTGVATGADGPNSASLNSLASELPTLSSYDASSMANISRMLDLDSVIDLCDGLDLPPSGLISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQQ5</accession>
    <name>A0A084WQQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020807</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525397">
        <property type="protein sequence ID" value="KFB52549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020807-RA">
        <property type="protein sequence ID" value="ASIC020807-PA"/>
        <property type="gene ID" value="ASIC020807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020807"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11843" checksum="823C94EF144684C5" modified="2014-10-29" version="1">MKPSKTEQQTVSLSNKLLLPRAAEKTDRKKETPRHGSVVSKNYKIIYRQLTQSLPGPSNRGAQTTTQFVCVLGGRRLTDSLNCHRRIQHSLCCRLLAVLKFPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS64</accession>
    <name>A0A084WS64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021254</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021254-RA">
        <property type="protein sequence ID" value="ASIC021254-PA"/>
        <property type="gene ID" value="ASIC021254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021254"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="15492" checksum="276571B3F7E2BDFF" modified="2014-10-29" version="1">MKLINVHHVLSGLNRTPLWTPKSRNSSEVRSVEFWFAVAKEPVRSFIFGECRLLARGRSKAAMAADTTINSKNGTRNHLERVGARQHGGRPGAEARDGCSAFGAGFAFGVSHSNGTVVSSPSPSRAIPRCPWVGVRRQPSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSD4</accession>
    <name>A0A084WSD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021422</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525414">
        <property type="protein sequence ID" value="KFB53128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021422-RA">
        <property type="protein sequence ID" value="ASIC021422-PA"/>
        <property type="gene ID" value="ASIC021422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021422"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10481" checksum="A52FAE01FAF09B3F" modified="2014-10-29" version="1">MDYRNHLGTSLPHQSFSSTLPPIREKVHTIEPTDRPFPSSLKKLVCYKLSALYDAGRIDAGSRNVLRRIAPVRYGCGAIIAHVHHTSSADRTGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSE9</accession>
    <name>A0A084WSE9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01026503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021440-RA">
        <property type="protein sequence ID" value="ASIC021440-PA"/>
        <property type="gene ID" value="ASIC021440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021440"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007718"/>
    <dbReference type="OMA" id="FEAGVWY"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF12">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="70"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="413"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB53143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="556" mass="64115" checksum="4AF874A7DFB34029" modified="2014-10-29" version="1">MTERGFDVTHANLVLCEWAVSLWGRCVLAEWHVQVALTENSPTRTRLARAHFPLRRXXXXXXXKGKTIFVTGGSGFMGKVLLEKLLYSCSDLERIYVLMRPKRGKSPQTRIDDWLKLPVFKRIQEEKPHVYKKLVPIPGDVTSDRLGISPEHEKLLIETTDIVFHCAATLKLEAKLKDAIEMNTVGTKRILDLCQQMKHLTALLHLSTAFCYCDKEVLTEKVHDFHHNPYDLMRTVEWMDEKALDMITPNLLTPHPNTYTYSKRLAEMLVRDVYPNLRVCIVRPSIVCPANAEPVEGWVDSLNGPVGIMVAGGKGIIRSMLCNGEYNAEVIPVDLAINGLITIAYTLGQMAEMPKEIPVYNITCRETKRTTWKEVLDLGKQTAYEYPFEAGVWYPDGDITMNKTYHTMCVIFFHWLPAYLIDFLMFCFGQKRFMCRIQTMVTEGLSLLQFFTTRQWDFKSHQYQAIEKNLTPDDKRIFTMDVDAIDTKDYLRRIILGGRQFCMKEPLSTLPKARIQLKMLYVLDKVAKAFMLYLLLWLFLTVTGLRAPVYEMFGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSP3</accession>
    <name>A0A084WSP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002557-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026652">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525416">
        <property type="protein sequence ID" value="KFB53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021557-RA">
        <property type="protein sequence ID" value="ASIC021557-PA"/>
        <property type="gene ID" value="ASIC021557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021557"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014569"/>
    <dbReference type="OMA" id="WICSIRY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="32180" checksum="109F6A873D39D2CB" modified="2014-10-29" version="1">MYPNPLGPPGRFSHANXXXXXXXVGVRPIHDLPGVGKNLHNHVAYFINFFLNDTNTAPLNWATAMEYLLFRDGLMSGTGVSAVTAKISSKYAERANDPDLQFYFGGFLADCAKTGQVGELLSNDSRSVQVFPAVLHPKSRGYIELKSNDPLEHPKIVVNYLKEDHDIKVLVEGIKFAVQLSETDALQAYGMELDRTHVKACQNMEFGTQEYWECAVRQNTGAENHQAGSCKMGPTSDPMAVVDHELRVHGVRNLRVVDASVMPKVTSGNTNAPVIMIAEKGAHLIRRAWGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSY8</accession>
    <name>A0A084WSY8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00021639</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSY8"/>
    <dbReference type="STRING" id="74873.A0A084WSY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021639-RA">
        <property type="protein sequence ID" value="ASIC021639-PA"/>
        <property type="gene ID" value="ASIC021639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021639"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022310"/>
    <dbReference type="OMA" id="NHQWPKI"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01737">
        <property type="entry name" value="LSm16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000009">
        <property type="entry name" value="AGAP003131-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034107">
        <property type="entry name" value="Lsm16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="335"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="553" mass="59873" checksum="841C0083FC24233F" modified="2014-10-29" version="1">MSDKWIGKSVSIHCRDDIGVFQGIIKRVTPAEVVITKAVRNGIPLKKNNVEVSLSARDIVKFDLISCSNVPSIPLKPVATVAANSGMVTSLDDQFDGMTLMNNGKQHHQQQQSHPQPFQNGTGSAFKLASKSPGPVKYANNNTNPISQNKGDNGGSVKSTSHPIDINGPSSKSNHVVANSMATSATIGSFGNGRPLAMSQSLPYAEGSGKKNPTNGKVPRSRKNLAKDSTFGSPDDDPLLMDEEFDFEKNLALFDKQAIWNEIDAIQTKASEGEKRQRQAPNSAAKTKYRHDENVLASIPAQYRQIEIECAATALASQEYVTDEGLVIPSVPATVRNTVEQLAEGNGLSRQRQNDFLARGATELALQLLGGSRRLTPNNQHQWPKIVVVCDGTQSERLNEVGFSTARQLACHGLETVVYVSSVTDPTRVSTELPLYMATGNKFTLDVNTLPPCDLVIAAVTTPKLSERLRAWITNSRAPVLAIDPPGAGLEGISIKCSILPILPVNGIDANDACGRLYLCNIGIPNQFFNRAGIAYKSPFDKFVIPIHRRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTI8</accession>
    <name>A0A084WTI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Orf1ab polyprotein (Pp1ab)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021762</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021762-RA">
        <property type="protein sequence ID" value="ASIC021762-PA"/>
        <property type="gene ID" value="ASIC021762"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021762"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760060" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021762-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6739" checksum="9463CCF1DCA238D2" modified="2014-10-29" version="1">MADSFQKRQLERPAALLVLVALLSVTVSPSFGNKSTTSVHSSGNFSNLSDRVMHASIVTTGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU28</accession>
    <name>A0A084WU28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022100</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022100-RA">
        <property type="protein sequence ID" value="ASIC022100-PA"/>
        <property type="gene ID" value="ASIC022100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022100"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022100-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7010" checksum="5A6F19EB1B90CF71" modified="2014-10-29" version="1">MSQSCCLVDLEESLAVGSWDRSILIEAFGMAQPTFLGLSVNFFLPTVAPLPKPHSFRPGQASWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU93</accession>
    <name>A0A084WU93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP009704-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00022022</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01027018">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU93"/>
    <dbReference type="STRING" id="74873.A0A084WU93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022022-RA">
        <property type="protein sequence ID" value="ASIC022022-PA"/>
        <property type="gene ID" value="ASIC022022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022022"/>
    <dbReference type="OrthoDB" id="6765072at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="27812" checksum="B1971C3255FD6238" modified="2014-10-29" version="1">MTTALENYRICLNWLQTASRVVGLEFWGSRHRITPAQVLILVAMSTFFALTILTIYFSRGKALEMLQSLNFFFTAFTLAFKYFSFFPNRERIRRLTDRFEEKIYNIYKSSSSEYPLLVTYSRMLYITGHAITSLYIGGLFLFGTYPLVAYLREGRLELIFYIDIPFIDWTTKAGYWATFIMQLMLFAIGVCGMILVDYLCAFVSINGLLYVDIYIHHLDVFGKEIVHLVHKSMRPSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUV4</accession>
    <name>A0A084WUV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022251</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022251-RA">
        <property type="protein sequence ID" value="ASIC022251-PA"/>
        <property type="gene ID" value="ASIC022251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022251"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="13780" checksum="E7496E8293A206FC" modified="2014-10-29" version="1">MHHDAARPKRDALGDDPVRAGSGACIMQLAQVVTEIAAATGRQLPAETIVRGSLPFRSSGPFIRRGCTRTMLNNNQQLGATGSRGSNVAAVKARTKSYLPCRGAPNQDFGPKHETSLGVTATMVVCETFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9V2</accession>
    <name>A0A084V9V2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP010979-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00000101</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01000457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523882">
        <property type="protein sequence ID" value="KFB34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9V2"/>
    <dbReference type="STRING" id="74873.A0A084V9V2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000101-RA">
        <property type="protein sequence ID" value="ASIC000101-PA"/>
        <property type="gene ID" value="ASIC000101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022780"/>
    <dbReference type="OMA" id="RICITIN"/>
    <dbReference type="OrthoDB" id="7729869at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="552" mass="63465" checksum="B8CC9141B8C1A3CA" modified="2014-10-29" version="1">MVDEAQTTGEIMDEEYNETKFPTSPFCRICITINDVNYYIHQIVGEDGVASISLHRKLAKLFPAMFNDEQVHNDEINSWPSRVCQECKQMISNAYHLYELCVTSADRLKKLLAVEEVVLDETEKKMNIEVEEENQLVTPDEVLIKIRSGTNSTPGDEEAAGRRTSLRRNRTKKNVRTKAAIQQSAIKQESSHKKPLRKFTVGVKALKTKESLEIPTKNDPVDMVNNLNEAQIPPDDSTAIKIEEEDGQLSAPATNVTPVPKVTEKNRRTRTRASREGTRKEDMQTKAAIRNKEKIKEHLGDAREPETKIDLYRCQLCEGPTYTSPTELTDHLKQQHADQISCCDQCPKVFMSEQAFQHHQYCHAIGRSHFCMFCDKGFVTEDLLKGHVRTHTHRTDYLCFLCGKEFSNSSNLRQHVKRHYGEKPFTCDQCPMRFSTKGARFFSCEVCKMSDHVKRHMRTHTGEKPYKCGCCGRAFAQSNDMVKHMRTHLGDNAYHCDRCDASYRLLSELRNHYKEHYQPGDNPIGSSSVEEEKEIRFTSMNILNRLFDKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA42</accession>
    <name>A0A084VA42_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003530-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00000330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01001584">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523980">
        <property type="protein sequence ID" value="KFB34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA42"/>
    <dbReference type="SMR" id="A0A084VA42"/>
    <dbReference type="STRING" id="74873.A0A084VA42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000330-RA">
        <property type="protein sequence ID" value="ASIC000330-PA"/>
        <property type="gene ID" value="ASIC000330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000330"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017322"/>
    <dbReference type="OMA" id="DRCEVAY"/>
    <dbReference type="OrthoDB" id="6610259at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF2">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="13023" checksum="15258F28E34C394B" modified="2014-10-29" version="1">MDDIARGMRKVCLSKSKISEEIADYPSKGIFPDDQEFKCYVACLMDLSQTSKKGKLNYEAAVRQISILPEEYKQPFRQGLEACRNAANDVSDRCEVAYTLLKCFFKASPKFFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAY7</accession>
    <name>A0A084VAY7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase dlk-1</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DAP kinase-like kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Death-associated protein kinase-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00001052</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01004756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01004757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01004758">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524238">
        <property type="protein sequence ID" value="KFB35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VAY7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001052-RA">
        <property type="protein sequence ID" value="ASIC001052-PA"/>
        <property type="gene ID" value="ASIC001052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001052"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023650"/>
    <dbReference type="OMA" id="AFCIIME"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000087">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="148"/>
            <end position="390"/>
        </location>
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        <location>
            <begin position="17"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="956"/>
            <end position="1058"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="674"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
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        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
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            <begin position="763"/>
            <end position="776"/>
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        <location>
            <begin position="911"/>
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            <begin position="1035"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074193"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB35131.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116734" checksum="A9B995F299090850" modified="2014-10-29" version="1">MSIQEELDQLGLNNNEQQKQAQLHQQQPAPPYHPQLIYAGEYPAGANTDSSPELMHHQLHHHHHHVAATMTNGWPRLPVVTGAAGEPVVGVGVGIGVGLPGGKPAAATSWMDGLFGCMRPVLSLIGKGHIMEMKSKQTEDWEIPYETITDMVWLGSGAQGAVFRGKWRHELVAVKKVREVKETDIKHLRKLDHENIVKFKGVCTQAPAFCIIMEYCAHGPLHKKLQDSGGIISPQQLVSWSQQIAHGMQYLHSHKIIHRDLKSPNILIGENEVIKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCNEKVDIWSYGVVLWELLTGEVPYKNVDSSQIIFGVGNNSLYLPIPATCPDGFKKLIKQCWNVKPRNRPSFTILLKHLDSAGWELLEAWEKEQCAGYYETQKSWREEIRSHMTQLTSNGMNIQKYEQDLIQKRKDEWKHAQDIRMTYERKLERTNELYMQLTAYYLQLEQKEQEIAEREKHLPYKPQRKCGILKRTGDKSNRKRPFSFPSMAAALPGGCGESTTPSPTASGYTGVTVSPPRATLYAQVNPSGPQGARSVVVAPPPPYNTLAHMAAATNTTNITTAPTATVTLQQQSTTPLAPTPNSSGRTKKLRHRRVGSGTFNSQSPKSSPSRDRRVQSEPETRHVKLVDTETQTEAMEVSETDASPSPNVATKRMSTSLREEEQQGEGESRLQEEMMDDEQKAVSGADEVLRPAVSSVYRCSSKPQSEDDGEVPEDEENGNSISISTMTNSRSSDMMTTSGGSSPDPIMDAMNSNDERLDRACSDDDKIDTLDRKVNLISEKLQQSAAAYGNLLNDNNVIVYRCQQKLNQQPQKSPGSARRTGGGGVESPLGSTILLKHPGAASNLNVGGGGIGVYLYSGPLAAGLSTNGDGPAVGAKQQPQQQHQQQPTSGDVELRWTDEEGEEPVEKQYNNSYALRRKSVGRLPIKRGRRGKHSGPTGAAQALDHLPKVHRKIPSNVTVTDEENTSEYSHAPSSQRSTLESNPDLPSVVMKVGGRRGAVQQPMQRSTTSAKDTDDDXXXXXXXV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB64</accession>
    <name>A0A084VB64_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001275</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC001275"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="541" mass="60317" checksum="8696105B76009E11" modified="2014-10-29" version="1">MLFDTAIVVAVGIAQFAIGVAFAGITPYVGMALMNEGVNDLIYATTAFYSGYFSWQDYAKHKLRSVCLSVVTVGITGLVSKLAQAGRYAYQLYRPSLNAVARTVEGTQQVLNTVSGSMGLKQIATRVLRQTMYNMANSATVYMTETREQSECARLERECLAKPMEILNEHTVLGTLQQVYVAFGDEEAWAIVNSVSESTFTRKSGLLKYLSNIKNRMIVAISGKMKAKPVTRVSSHELSQQLAQICRVTDTLLNDLELKMKTKLDESELALESSTAEQTGGRHGYENFQKKVIARWEELLRGKIVEVIPEYGTDSTLKQSATLEKPCKDMDFRERFKNRKRQHKGMLERRDEEPLNSLLNHTQKYHKDLLSLMSKTRNPSLLAAIVRENIPMNYTCASACTFLACNVLLRRGVILSALKVVIEGENGMRQAFTYAKDGVVEKVISIRMQDNLYEVSASDSQASMDLPSTGRCLFEGLAKKIPGLHGGYSLRNEVADAIAIDPVLQYVVRQYYHSLPQALGSFGGTYHDRKKEVHEATSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBL9</accession>
    <name>A0A084VBL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Complement protein 1S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001865</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524461">
        <property type="protein sequence ID" value="KFB35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001865-RA">
        <property type="protein sequence ID" value="ASIC001865-PA"/>
        <property type="gene ID" value="ASIC001865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001865"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="13932" checksum="EB775B8B7108403B" modified="2014-10-29" version="1">MAPYRSLARPRSVVIMRHQRLTHRDGINDVRAGRPQTRVPSASAIDVRGRAETDPYICITFAFVTLRPVRYGPMLLPIERHPGGGGGPTKQGAAGAEGNYGNLWEIISFVNLFAKKGAYGGTGRSGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBV4</accession>
    <name>A0A084VBV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003896-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00002150</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524536">
        <property type="protein sequence ID" value="KFB35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBV4"/>
    <dbReference type="STRING" id="74873.A0A084VBV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002150-RA">
        <property type="protein sequence ID" value="ASIC002150-PA"/>
        <property type="gene ID" value="ASIC002150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002150"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007119"/>
    <dbReference type="OMA" id="VANDQFT"/>
    <dbReference type="OrthoDB" id="2377365at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF10">
        <property type="entry name" value="HMG BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002150-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="523" mass="57643" checksum="95EE4935AE2CDB46" modified="2014-10-29" version="1">MFNMEIQSEPEEKRESSNSNINNNYIDYTSNVPHDYDDKYAQIQPTPPTVANGIQPAARQAQKKSNKLKRYRRPMNDFLMFCKRHRKRARLFYSAKENRFITKKLGLWWSVLTEAQKHPYKVMSEEHKERYFTAFPDYQWTKTPNVVPETTSTAATVPNGEEDGSRTPSTDGGESPEEALHNDEQVAAQALLAISTGEGLPPMATFRLADVNQMGSLSTLIAGNGNHSAGTTMRPETSSNGLEHNYSVSNGTAEPVEEEPFRNMQHFLENMRPNPNQAAMSTFSAPPAVSVGTVEAQPSNTPASTSGRAARSCKGKRYKEFMEQQQLARHSHGNGSNPRRQTQKRSAAPTATVTSASATVPALPATQVPSTSTIRSEGVATPNRVPDDEAFAALHRELNAEIDQLPLFDIYEFLEKQNKRRKKPTVFQSRQETKGYITKELHPDAAAPGNDHFNEHSSSPTPPPPPVVDPPIAPSPPPAEVPAPPVTPISPAPPALPPTVPTKIVGSRKRKAPKESITRYTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC27</accession>
    <name>A0A084VC27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP003335-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00002289</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01009984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01009985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524560">
        <property type="protein sequence ID" value="KFB35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC27"/>
    <dbReference type="STRING" id="74873.A0A084VC27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002289-RA">
        <property type="protein sequence ID" value="ASIC002289-PA"/>
        <property type="gene ID" value="ASIC002289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002289"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009403"/>
    <dbReference type="OMA" id="MIVCIWI"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="719" mass="79442" checksum="3A168FB776BDBFCB" modified="2014-10-29" version="1">MSEEKRFLAIWWPLKLQITKRRARFMIVCIWIIALGSTVPWALFFELVPIIPEAPDIKLCVEVWPPGTDGALYFLLANLVACYLLPMTLITICYILIWIKVWRRSIPGDSKDAQMDRMQQKSKIKVVKMLVVVVILFVLSWLPLYVIFARIKLGGALESSEEELLQIATPIAQWLGASNSCINPILYAFFNKKYRKGFAAIIRSRKCCGRLRYYETVAIASSSTSTRKSSHYHNGSKRAGGSPSVKSADVVSYIYEEKGGRKHHAISKQNSDLSRHMLLKQDSSISRQSLLLKQDSVASRSAILYRQDSDNSRQMLLKQDSNGSRDMLSKQCSASDSISRQDSQISYIDPPRKGILCKQDTQISYIEHSNGGVGGGAVGTPASKKYSASLSSQDSVLSIIEHKRHKLVKQDSIFSFNEPKSGKLLPASWRVRGGRRPPPSQKHPARIHPPARPAARHHARTHACTHPITSPIPTANSHCCASAIFENCIPAPYPPAPPPTPTPPTPPPPPHAIVAGRSHRGRYAGSLGVISESHATHFPCSNAAGSSSCAAISRPDSSLGSVCERSACGACILHQAPAGRRRRRWFPFGGTRRASTGDERRHQHHHPHQHQHRPQCHLVGTSELSATNPHPHPLLFLLIVVYESATPAPFKRHQLVKQHSVISFADQRRGGSLTKQDSVTTIHRAGNGEGPYISSILKKTDSQCSSASPVRKNIGFFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC51</accession>
    <name>A0A084VC51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005902-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524584">
        <property type="protein sequence ID" value="KFB35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC51"/>
    <dbReference type="STRING" id="74873.A0A084VC51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002386-RA">
        <property type="protein sequence ID" value="ASIC002386-PA"/>
        <property type="gene ID" value="ASIC002386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002386"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021982"/>
    <dbReference type="OMA" id="FTRHYAQ"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20027">
        <property type="entry name" value="FH_FOXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047514">
        <property type="entry name" value="FH_FOXL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="489" mass="52461" checksum="DA5214640B3D90C8" modified="2014-10-29" version="1">MHTLFTDQRHYGHAQPGYPTNGPTMASAHHYPYDQYSRYAYAGSAYALAAPHQNKEMVKPPYSYIALIAMAIQNSPDKKITLNGIYQYIMDRFPYYRDNKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSFLRRRRRFKKKDALKEKEELMKRQSLILSSEDKMGGDIKPIKIMSGGHHHLDGKHHHHHHHHHHAQLHHQALGHHQTTFKREPGLELAAAAQCMVKDVGLTSTLLNTCHDTFATQMNHLSAAGDHGFTVDSLMNVYNPRLHHSSYPYHFNDDNLMTPGSGGQLRHHHGTSSHHAPPHGGWYTPETPPESIGNTSGSSTTTPTTLPSVTVTPTSGIGVNGGGGGGLGVGGGSLGGGVLSHQSVGGQSGGGGGGFRDMVFDHNQASAAAAAAAAAVAVNCQMEQAGSPGGNSLTSASPPVNSAAAAAAAAAAAASGHLGGNLGHLGHYRSHVGYYQDCGLKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD40</accession>
    <name>A0A084VD40_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001696-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524645">
        <property type="protein sequence ID" value="KFB35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC002837-RA">
        <property type="protein sequence ID" value="ASIC002837-PA"/>
        <property type="gene ID" value="ASIC002837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002837"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002793"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010136"/>
    <dbReference type="OMA" id="EKGWLNK"/>
    <dbReference type="OrthoDB" id="10033661at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="836"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1469" mass="158425" checksum="9383DD624DFBB1CE" modified="2014-10-29" version="1">MSITGSLVGYETGGDITMGSKKNRSLLNITATSNASSKNCQSLNSSISHGSVVLPGNTSGSLRRHAQPPIASSPTKHRRRRLHLNTLWSIWYGILVTLLQGYLIVQGTHRYIGLSALSWKYEKPTTELDIQIVFCGLVVLFLPLLLASALFRVGNLANDGMKLASGTKLWQGSPSAGHDGLEEEAFEGTLRSLWIHGGPTSAFIHIITAICLLLPRLLLEAKVIENGLLPRDKQNGNKQLLLRLKSCLSFAYRPKGNQHSSRHHGNRTVQVSAPSLPLRPPRPSVCVCMRGKAARFLWTVVLSRTSPNKHSNHNVWRTDLDFMVTHSDRLVVLSFMTSSPTSANSTASTVRPGLSELERKLYRNGYFEQSDLVEKFADYDDSLGALDTSDEVFRTHEALEMGTLFAGGVNGPPIAISTMENFHLVEPPTTLHTLPPVRNLRTTTAAPATGMGKHHRHSTLAPITTTVPPYSSGEGSRESRRKEPNRNSGHHRKASNGKGHAGGKVKSQHAHHGNHHSQQQQHHQEQQPRHRYVEEVDTRLELEEQQELDWSALNQPEGAPTLIEPATSGTGGSKKSPSQKGNRPTSTTTIQPATTVRSAPSKRPTTTTTLAPTAMKKPPVTTKDSDIHILKPVNLPENIIPSTPVTTNSKIIEIKPPKGSTVASAKSSVVGVNRKNKRESSAGGENFSSESLESIESIPSVDEDEFIIKDENGMEIKPAFLIGAAPGNLTFRPMQLVGFPALLAKLFGSPVERQFSAGSAWSTVPSAEFVNLAVALAVWAVRYPSVFWHTSKSFACLFSLQMIANGVDILLSFAGASVLYKLQTLGQALPLQAPALILNGTVTVALTILALVLTIASSMVLYLYGHGKLAAKVRDRRMITAKQSADVWAYFAHCSSLCFVLALAVVKAPLMHDLSATYRGSLDGAVLAAALGSVVHLFLWIVLWLGLTAKRRWHFKLPPLDGGRAYGGPGTASQPLLRGNGSLRSPNGTSNGLQASAGPPGPGGASSGSGGEEETIYWPKIAPNSPKLKVTFNEVPSTSSELALGPHEHGNKRHPSGGTTIRLSSLTGEADDGDYATLRGPTGDLLHLGPYEHPGPSGSSPPPPPPPPQLDDCDLLDEASNSNTLVGSTNDHADDTSEEGKLLACVRDDSVTYASTRDLEPPISRTMSRETFMRSPEQSLSSPLAPVTVTVHNHLENVGPGSTPRCLRRADSGMPTEALTPRSDSTSTESSTSPPDCRDAPSETSSGVHSGEERDEVVIRPRSGPYKSIIKAPPPAIQEEPFGRSTNMKMSSFNKDGTSATLPLTRGSTDMHHRSEYPQCSTMPLPAGYHQQQHHHYHSQTSFTPPQSGSSRQQLQQHTTLPNGLRYATSSNQFLKRLPYMKNAESPYGHLGLGAGHHTFSKLLHDPLSGGGGGGVPGMPSHSHSSHSTFLPPATIPEDRDSANYSMISDQDREMYINAAQIGGMQMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDX6</accession>
    <name>A0A084VDX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003346-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003238</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524732">
        <property type="protein sequence ID" value="KFB36170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDX6"/>
    <dbReference type="STRING" id="74873.A0A084VDX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003238-RA">
        <property type="protein sequence ID" value="ASIC003238-PA"/>
        <property type="gene ID" value="ASIC003238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003238"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022760"/>
    <dbReference type="OMA" id="YKQRYVG"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003238-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="629" mass="72017" checksum="B5B4A4522F97A99C" modified="2014-10-29" version="1">MKRKQQYGSVTNVTKMLSDRAYWDVEGILRNRLRAAPQFVDFIDLETELKGHNGCVNCLQWSDDGHILASASDDLHVKLWDPFRHTQLHDIATPHEGNIFSVKFLPQRGNAVLATCAGDSKTFVFDINRQDENPTRRCVCHLHRVKRLATSPRNPHLFWSAAEDGVVLQHDMRVQHTCNQQDNNVLIDLRNYLWVSPEIKCIAINPQRPEQMAIGANDCYARVYDRRMISLSRLYDPREIGDGLVVTTRIDKIPNDGCVKYFCPGHLNGDEKVNMQYNFKTITYLTFSPDGTELLVNMGSDHIYLFEINGSRQPVFLELPKLPPTSNGETNGCVGGEKTKHKFPPDVEQLKMEGNDNQERSQYLQAINKYTQAIRKANSKDCAILYLNRATALMRRDWYGDAYAAVRDCHTALRLDPHYVKAYFRLARALLKLEQSKEAQLCLDELIQRFPSYAKNQGVLLLGKDIGIELDKQRVRASESRFSIYEGNYFHDKEKGWRAKAIDYEKRFVGHCNTKTDIKEANYFGDSNYIVAGSDDGRFYVWDRHSGLVTASYKADELIVNCVQPHPYVCLLATSGIDNEIRLWTPKSPEGKFERKEKHLDACVSENQTRMKADPFEEMTPGQAICRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEY1</accession>
    <name>A0A084VEY1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Rhs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003662</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524784">
        <property type="protein sequence ID" value="KFB36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003662-RA">
        <property type="protein sequence ID" value="ASIC003662-PA"/>
        <property type="gene ID" value="ASIC003662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003662"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11347" checksum="25C3E2638DCAA5E4" modified="2014-10-29" version="1">MASSVPKESLASPSRSAVICFVFLWIAEKSRQSVERSSRHERTDIIYCDSRTLPWDVREAAGDARIFGQRDHLTPPLTHVHWRQTALEGNTQAGISNGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFF4</accession>
    <name>A0A084VFF4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00003847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01012386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFF4"/>
    <dbReference type="STRING" id="74873.A0A084VFF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003847-RA">
        <property type="protein sequence ID" value="ASIC003847-PA"/>
        <property type="gene ID" value="ASIC003847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003847"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003506"/>
    <dbReference type="OMA" id="FNRPGPN"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="671" mass="74132" checksum="DD43B330B02B4BC7" modified="2014-10-29" version="1">MSGEENGKPPSASTGPKGRILPADSYVSTDPAVPVKLRIAKEGLAALDPLSVPDLMDRTVRDHPDHPAMVFRNAQKHWQTVTYREYRERVHHMAKVFIKLGLEPLHTVAVLAFNSPEWFVSELSAIHAGGIITGVYTTNSAESTQHVLESSRAQIVVVDDAKQMEKILSIRSNLPNLKAVIQTMPPYAPYVKREDGFYRWSELEEMNVDDVEEEYKNRLANIAINQCCCLVYTSGTVGNPKGVMLSHDSLTWDSYSIGKRLHQIRYAEEVLVSFLPLSHVAAQMVDIFLTLQFACTVYFADKDAMKGTLLNTLQEAKPTRMLAVPRVYEKIQEKMLAVGAQSGAAKKLVAGWAKSVTLQHHLNAMEGKPTNSWQYRLVKNFILSKVKDALGLSRCLTLATAAAPMDRETKKYFMSLDMPINEAFGMSESSGAHSLTAPDSYNFDTIGKPLGGCETKIDKPDERGHGEICMRGRHILMGYIGEEAKTREALDDEGWLHSGDVGYVDEAGFIYITGRIKELIITAGGENIPPVHVENLVKNELPFVSNAFLVGDKRKFLTMLITLKTQMNLDTGAPKDELTPETIAALKEFGVEYGKLSEIHAAGPCPKVLKAIQDGIDRANKKAISNAQKIQKFALLTADFSVPGGELGPTLKVKRNVVVANNTDIIEKFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG16</accession>
    <name>A0A084VG16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP002060-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012595">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG16"/>
    <dbReference type="STRING" id="74873.A0A084VG16"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004080-RA">
        <property type="protein sequence ID" value="ASIC004080-PA"/>
        <property type="gene ID" value="ASIC004080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004080"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004983"/>
    <dbReference type="OMA" id="FRYNQAF"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF2">
        <property type="entry name" value="RH61964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="478"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="708" mass="79050" checksum="BF699626259D00F7" modified="2014-10-29" version="1">MENGFICQILFSTSREKQVTSYGLLGASGCGKTTLLSCIVGRKFLNDGEINVLGGTPGTAGSGVPGPRIGYMPQDIALVEEFTIKETIYYFGRIYGMSKEKIRERYKLLKHLLELPDDERYVGNCSGGQQRRVSFAAAMVHEPELLILDEPTVGLDPLLREKIWQYLVETTSTSKMAVIITTHYIEEAKQAGCIGLMRNGILLAEDSPVNILERFSCTSLEEAFLNLCQRHGPSEEADRNTHQTQALRAVTAAPDVKKTIPALATSEKKPAEGGGGGGGGLFGEKRKPITGTIKQLVSFTTKRRMNALLSKNFLQMVRQPAGMVFLFLYPIFQLVSFYIAIGGNPKGLRLGIVNEELTNIRQCFNESLVHTYYTDDYECDLYKVSCRFLEKLNRSIAIQEYYDTYEDAYRDARKGKIVGFIHFAENFTESLQDVRDNVRDADDGSFLTSEIKVHLDKSDQQITFFLEKKLLQTYREFAESLMSDCRLSTQLANIPITFETPIYGTFDEEFTDFMAPGVVMTMIFFLATLITATIFITDRLEGVWDRTIVAGITALELLLAHIITQTSIMLLQCVEIVLLATFLFDAQNQGSNITVVGLLMLLGFAGMLYGLLISIFCDAQSTANFMATGSFYPMIILCGILWPLEGMPQYLQYVAYCFPFTIPSIAVRNVLTKGWSITNSQVYMGYGAVGVWIISLLLLCLLGLKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHF9</accession>
    <name>A0A084VHF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">CRE-LIN-13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004534</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004534-RA">
        <property type="protein sequence ID" value="ASIC004534-PA"/>
        <property type="gene ID" value="ASIC004534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004534"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8578" checksum="A251679E444DAD2B" modified="2014-10-29" version="1">MKRLRDLWVRPKNRPQQQRCSCPVQIRCCSTGAAPAMAISKRINAKLQHLALGGLEVDGKRWVGGEGRAIGDKIREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI32</accession>
    <name>A0A084VI32_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00004863</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01013269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524849">
        <property type="protein sequence ID" value="KFB37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI32"/>
    <dbReference type="STRING" id="74873.A0A084VI32"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004863-RA">
        <property type="protein sequence ID" value="ASIC004863-PA"/>
        <property type="gene ID" value="ASIC004863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004863"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011848"/>
    <dbReference type="OMA" id="WAGTMRY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB37626.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="301" mass="33233" checksum="A46FB61A2A2B552E" modified="2014-10-29" version="1">MAESYKVETIPPYTELGEGPHWDIPSQSLYYVSLTNGLIYRLDYKENKVYCASIGLRDCFVIGDGGRLLMIRWDGLSKKASIVKELANTGPKDTHNRFNDGKVDPWGRLYAGTMLHESVGSPFEKATGSLYRFCAASGKLVEQDRNIYISNGLAWNRQTNKFYYVDSGANNIKEYDIDLEGNLVNGTIWYDFKAPGNDPGGFGDGMTIDTEGNLFVAIFNGYKVLKISPQKKVLQVIKIPAQQVTSVAFGGPKLDELFVTTAAMTFTTPQKDPAGATFKVTGLGVKGYPMDEIDLSKVKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIC6</accession>
    <name>A0A084VIC6_ANOSI</name>
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        <submittedName>
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        <name evidence="2" type="ORF">ZHAS_00005030</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB37720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11089" checksum="3D312189A5979EB8" modified="2014-10-29" version="1">MQKAVRSSHQNQNNLPKTRHERNIIAPNDNMPAFGSERAPDASEAHGSGANAKSRRVSVVFRALVRVAVELENKRNKYFVRECFSLDPERPTFAVKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJW6</accession>
    <name>A0A084VJW6_ANOSI</name>
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        <submittedName>
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        <name evidence="2" type="ORF">ZHAS_00005580</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005580-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="14858" checksum="0BAA294736F7CD00" modified="2014-10-29" version="1">MESGPTGGAFNAKSRENEGAGAGRDAAYIRLIRLGRTAIEGDRAPSDSEATNRAEAVGNAVPAVSCRFRKAACFRRNNDRSSRVRSNRARVRHGAQLMMGTVRASMGRPGFVLKPVGHRVRQGLAHKLQLHNAAPVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX0</accession>
    <name>A0A084VJX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP010341-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005584</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013910">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084VJX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005584-RA">
        <property type="protein sequence ID" value="ASIC005584-PA"/>
        <property type="gene ID" value="ASIC005584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005584"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015634"/>
    <dbReference type="OMA" id="KATHMVD"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005584-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="313" mass="35997" checksum="70534492EC5ED160" modified="2014-10-29" version="1">MPFAGESPIPSPIEARFLPREIAVLLHIRHPYIIRIHAIIKCRNIVCTFMRFAEMGDLLSFVIEHGPLRESQSRIWCRQLSLAVQYLHESGIAHRDLKCENVLISANFNVKLADFGFARYVTLKNRQVQMSTTFCGSFDYSAPELLKGKPYNPKASDLWALGVVVYMMLNKSVPFKGKTRQVYEQQMMRAWKFRTRVNDILSPEVKTMIRSLLEPNPVIRWTVEEVLVCDWLIQDRRLRSLTADEFTALAEARTFNRSSANMESVKKKLRQKESTEHSVTMIKESYSKVEENKLSGALISPKISVVEATQVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK56</accession>
    <name>A0A084VK56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005704</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005704-RA">
        <property type="protein sequence ID" value="ASIC005704-PA"/>
        <property type="gene ID" value="ASIC005704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005704"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005704-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="9394" checksum="3DEF28141D9C524A" modified="2014-10-29" version="1">MKINKVSGNVVTSGGGGGGGGGGGGGGGGGGGGGVHTGAGKETQLDLEPSRGENSRDWRDEAMVFQQEVNGSLGDTNIDPLREPLAWCGEGLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKF9</accession>
    <name>A0A084VKF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dsim\GD21969-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005851</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKF9"/>
    <dbReference type="STRING" id="74873.A0A084VKF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005851-RA">
        <property type="protein sequence ID" value="ASIC005851-PA"/>
        <property type="gene ID" value="ASIC005851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005851"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016618"/>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759848" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8739" checksum="B208A2065746E4D8" modified="2014-10-29" version="1">MAPAFARTFVDIVSVLVLAVLPIGTGGWKLDNRNILYTNQDISYECPINTMCRCASLPNETALLEINCNEVSLYKFPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKW1</accession>
    <name>A0A084VKW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005982</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005982-RA">
        <property type="protein sequence ID" value="ASIC005982-PA"/>
        <property type="gene ID" value="ASIC005982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005982"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13734" checksum="FF6A3E450DED8C1D" modified="2014-10-29" version="1">MRTPLNRTPVRCCCYDVPARKKPSIRNPTTVFHHSLHSGGRFAECCATLKLLNVPTFAGGMRTTVERIACKSLVVYPPPATAPASSHRHISTPGVHIGHNGVWPWRVAMKYCICGKSGRNRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKY5</accession>
    <name>A0A084VKY5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006016</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014339">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524959">
        <property type="protein sequence ID" value="KFB38629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKY5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006016-RA">
        <property type="protein sequence ID" value="ASIC006016-PA"/>
        <property type="gene ID" value="ASIC006016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006016"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12723" checksum="5F57E23A75CA5120" modified="2014-10-29" version="1">MHPKPSLDTRVRPVCLTHKGVGNRAGGKTKAAGELHEPKRSRTVDDPWQQQPRMHPTNDHGSGWRPSVRAQLIISFSADRIEVWVLCEAKHVVDGTVDGTVVVPGEVRRHVRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL33</accession>
    <name>A0A084VL33_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006072</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014403">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL33"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006072-RA">
        <property type="protein sequence ID" value="ASIC006072-PA"/>
        <property type="gene ID" value="ASIC006072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006072"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13125" checksum="BF3EDE8F0768E262" modified="2014-10-29" version="1">MVSYHNAAQQAYTFVRAPALSPGRISRLSLISSPCRESSRSEACPRKWGPSYRPALEHLHMLLAYLCVAFGLLRHDVVEEAAESIGNTLYSAISHHTGHQKQTLPNSVVCLSLGYFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLA3</accession>
    <name>A0A084VLA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004135-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006147</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014437">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLA3"/>
    <dbReference type="STRING" id="74873.A0A084VLA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006147-RA">
        <property type="protein sequence ID" value="ASIC006147-PA"/>
        <property type="gene ID" value="ASIC006147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006147"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002962"/>
    <dbReference type="OMA" id="DANFYSP"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF19">
        <property type="entry name" value="RE55542P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783800" evidence="5">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB38747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="534" mass="59294" checksum="23E39539D241995A" modified="2014-10-29" version="1">MRGWSFLAALCCLSGGVLCLGDAAPKMDVVKQWNLLNFNFPWDYPASNKEFYNPENIVVTGLEVGYDRIFLATPRLFSGVPATVSSIPRGTNGDSPVLQAYPDWTHHRAATKEYNCSDIGLVSVYRLRIDSCNRLWALDAGVSRSLEDYEITCPPKILVYDLHTDQVVRRIDFPREVIRGESLFTNLIVDETGSRPENNCDDVFVYISDTVAPGIVVYDSGKDLTWRVSHPAMYPDPDFAESSILEHRFTLMDGIVGLAFDMEAGIVYFQPLATDRIFSVTTSALRAGPLPFGKELAVKLVGRKSSQGIGLAVSPRGGTLFYAPLSETAIASWNPRTNEHRILAHDQDKIQFAADLRTPDRDGTALYVLTSKFHRFFLKNLDANEFNTRILRIDGVVNPSGQLATQSHLRPTVPYETLTGNAYYHPSVVIPVPYKPLPPGQSMALPPPASTSTPIGLFNSQNIPFGQNPLAKSPLDKPKPSYPFFSLNNGEKNFPPSRPSYGSSGFVPKINFNFNDNNLLRYRKSLPVNQTIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMS6</accession>
    <name>A0A084VMS6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006621</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006621-RA">
        <property type="protein sequence ID" value="ASIC006621-PA"/>
        <property type="gene ID" value="ASIC006621"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006621"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006621-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8415" checksum="A4EBF093AEE2E6D9" modified="2014-10-29" version="1">MLPFGDRSVRFTSAFVVPGMHSDAVREKPVPTCRSLWADVFCTVPRAGRRNARSAFDVLCEVSLFGAEDALVPSGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMZ3</accession>
    <name>A0A084VMZ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006697</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01014635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMZ3"/>
    <dbReference type="STRING" id="74873.A0A084VMZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006697-RA">
        <property type="protein sequence ID" value="ASIC006697-PA"/>
        <property type="gene ID" value="ASIC006697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006697"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006256"/>
    <dbReference type="OMA" id="FKFPKVH"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF3">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE E11, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="24845" checksum="71E3B49A3404D8A5" modified="2014-10-29" version="1">MPNIKLYTTKLSPPGRAVELTAKALGLELDYVPINLLAGDHLKEEFRKLNPQHTIPLIDDNGTIVYDSHAIIVYLVTKYAKDDSLYPADPATRAKVNSALHFDSGVLFARLRFYLEPILYEGSPDKPQEKIDNLYRAYGLLNDTLTGDYIVGNSLTLADLSCIASISSIHAIFPIDQSKYPKLAAWVDRLSQLPYYKATNQEGAEELAQAYQTILAKNQAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN88</accession>
    <name>A0A084VN88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006921</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006921-RA">
        <property type="protein sequence ID" value="ASIC006921-PA"/>
        <property type="gene ID" value="ASIC006921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006921"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11567" checksum="9BD2C6804174E857" modified="2014-10-29" version="1">MVRTLTPFNRQRNECSDGSLLFSLAKEVAARLRKCLHLCTGPDVSMDVIGNGHDGDHCLLRAGGSCVALFYAAVISTFSASSGSVHPTILYQCVSLRILTNNSRCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPF7</accession>
    <name>A0A084VPF7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">G-protein coupled receptor 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00007223</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPF7"/>
    <dbReference type="STRING" id="74873.A0A084VPF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007223-RA">
        <property type="protein sequence ID" value="ASIC007223-PA"/>
        <property type="gene ID" value="ASIC007223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008759"/>
    <dbReference type="OMA" id="HWRQNAA"/>
    <dbReference type="OrthoDB" id="411630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000072">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF46">
        <property type="entry name" value="METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783722" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="20">
        <location>
            <begin position="19"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="21">
        <location>
            <begin position="563"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB39851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122078" checksum="C3B5E57241A0D4EC" modified="2014-10-29" version="1">MKRSTLVMLLAFVPQLMASESVRGSPPNHTKELNRNIINTVFERTRPAGSERRGREVTILGLFELSSKGGERREGFSELAAAQLAVQHINRRGLLLGYKLKLITNDTKCDPGVGIDRFFHALYTHQSKRIIMVLGSACSEVTESLAKIVPYWNILQVSFGSTAPALSDRREFPLFYRTVAPDSSHHPARIAFLMHFGWDTVATFSQNEEGYSLAVNDLVTELERANITCAATISFAETDFKEQLKLLRDRDIRVIIGSFSHEIAPKVFCEVYNLGMYGAEYAWILQDTHISSWWLSHTDSCSSKALLTAVENLIIVSSYNSIVGMGTALSGLGFTLFHYKTNDIFLQKLRDMNVTGAVSQFAPQTYDAVWAMALALRGAEKTWSQKRANRVHLADYDYTRYDIAKELLHQFDSLTFNGISGPVSFEGADRIGTTSFHQIQRGQLQMIAFYYPKNATLDFGCWYCVPVVWASEQVPIAKRVLKLRVDTIDPLAFYTVVILSTIGIGISFLFLGLNLRFRKLKAIKLSSPKLSTITVCGCILVYTATILLGLDHSTLPWSSVTFSTICMARIYFLSAGFSLAFGSMFAKTFRVYRIFTQSAGGLCRDKILRDTQLISVIGALLLVDASVVSFWMAADPMERHLHNLSLEISTTDRSVVFLPQVELCRSRHYESWLGTLYAYKGLLLIVGVYMAWQTRNVKISALNDSQYIGISVYSVVITSASVVVLANLLYEKVTLAFVITAGFVLISTTATLCLLFLPKIKDIFVKGEVYDPIIHSMGLKLEFNTRRFVVDDRRELQFRVEVQNRVYRKEIEMLDAEICRLERLLGERSLANSPRSSEPNLQETRPCVIPRAHGSTGLPMLLLSVLPPIIPRASWPSVDPMLSPMKRNIAFSSQPKIDPTTTRERILTSSRSVFEDQSVATNGSGSGVMGKIRHMFTPRVHKTPSVSVIGPSATIRKSTLTVFNEIDTEDDSSFAVPQSIYTITAPKSDELNLTGSEPRVNFILPPNGKRRASIVQQQQQPGVVRERIRGSPRFPHRICPQTTSLTELGIERPRISFLTVKSCEQIHGRQCDSRAKWKSMDSFSKSISSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQB4</accession>
    <name>A0A084VQB4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000488-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQB4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007696-RA">
        <property type="protein sequence ID" value="ASIC007696-PA"/>
        <property type="gene ID" value="ASIC007696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007696"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="10223" checksum="BD9795FDC6B8E57A" modified="2014-10-29" version="1">MNLEANVSSPEVDIDVNVVSSPEPSPRPLESPQGHAGVASDDEQRSRTEPVSKKGLGVITPVASLPLSAAAAAAAAAASVSHGAGVGLGANGTPNSQDAAMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQH5</accession>
    <name>A0A084VQH5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQH5"/>
    <dbReference type="STRING" id="74873.A0A084VQH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007595-RA">
        <property type="protein sequence ID" value="ASIC007595-PA"/>
        <property type="gene ID" value="ASIC007595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007595"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008044"/>
    <dbReference type="OMA" id="ICEAYND"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB40219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="20334" checksum="60227D6C54660421" modified="2014-10-29" version="1">MWTTATAIPSRQAPIHFCTQLPEHPEHAFHQKRMALPTSLDKDAIREAYEDVRSNLNDYEWAVFKFDGLKIVCSAKGQGFEEFCSEFQDDERAFGYIRIQMGDEMSKRSKFLFLTWIGPEVGVMQRAKMSTDKSIIKDVINNFAVELQVETSADLDLEMFKAHLNKAGGANYGTGVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRH9</accession>
    <name>A0A084VRH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP004476-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008072</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015670">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015671">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525026">
        <property type="protein sequence ID" value="KFB40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRH9"/>
    <dbReference type="STRING" id="74873.A0A084VRH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008072-RA">
        <property type="protein sequence ID" value="ASIC008072-PA"/>
        <property type="gene ID" value="ASIC008072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008072"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001442"/>
    <dbReference type="OMA" id="FGWCVDR"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000401">
        <property type="entry name" value="Vesicular amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="251"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="460" mass="50132" checksum="C2639E263AC7DBF1" modified="2014-10-29" version="1">MKHDDTSHHNHRTAILPIIPEFLYDIRHPDAPLASFPKTPPTTLSPCEKETTTPYNGIDITTQGYDNASWYAEREERHKELVEETVEVGLMFASKAFVQLLANPIVGPLTHKIGYSIPMFAGFVIMFISTLIFAFGRTYSVLFLARALQGIGSSCSSVSGMGMLADRYTDDKERGNAMGIALVTFLPASISYLIGTNLFGPLGHRIGRWLAALLGLVIIGLCLLCLIMLQPTMVIEESDPPSLKALVTDPYIIIAAGAITFANMGIAMLEPSLPIWMMDNMGASRWEQGVTFLPASISYLIGTNLFGPLGHRIGRWLAALLGLVIIGLCLLCIPMATSINHLILPNAGLGFAIGMVDSCMMPELGYLVDIRHSAVYGSVYAIGDVAFCLGFAIGPALSGTLVNTIGFEWMLVGISILCFIYAPLLTFLRAPPTKEEKKSLIVGERSSVRYVTYQNEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRT3</accession>
    <name>A0A084VRT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP013305-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00008295</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015778">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRT3"/>
    <dbReference type="STRING" id="74873.A0A084VRT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008295-RA">
        <property type="protein sequence ID" value="ASIC008295-PA"/>
        <property type="gene ID" value="ASIC008295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008295"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024489"/>
    <dbReference type="OMA" id="EYMVALT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB40677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="503" mass="57111" checksum="520E9D9C2A10DD7C" modified="2014-10-29" version="1">MLLQVLATAFAIGISWVVVTVLRNRATIARLKKLLPHFDAVPSLPVLGTSYHFKDPSPEGIFATFSGFHRLYGRNLFTEGLFNQPAIQITDPKVIEQVVQARTIEKTIIYDFMVPWLGTGLVTSAGAKWAQRRKIITPTFHFKILEDFLVIMNHQADVFIDKLTAHAGGPNFDVYEYVTYCALDIISESAMGVKLNTQQHPNAEYVQAVKEFLDLVHKRIFNPLMRSNIIYSWTEAGQRQKKLESVLNNFMDTVMQERKHSLINNAAHESNGKNHSIKTTFLDLLLQTRHDDEPLPDKEIRGEVNTFMFAGHETITSCVSFALYYLSRNPNIQQKVYSEIVSVYGAEGNVRSATITLPSLQQLKYMDMVIKETLRISPSVPFIGRSSAGDMTVDGVVIPAETEVLINIYIMHNDPDQYPEPDRFLPERFEDEDGKTSFSYLPFSAGIRSCVGQRFAMLEMKTILVKLLANYRMLPCKQENELQFKSDLTLKPSKGAFIQILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS81</accession>
    <name>A0A084VS81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003052-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008348</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525037">
        <property type="protein sequence ID" value="KFB40825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS81"/>
    <dbReference type="STRING" id="74873.A0A084VS81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008348-RA">
        <property type="protein sequence ID" value="ASIC008348-PA"/>
        <property type="gene ID" value="ASIC008348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008348"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007773"/>
    <dbReference type="OMA" id="PHNAVYF"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000013">
        <property type="entry name" value="LD24721p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="36267" checksum="5881A0F9C3A08C19" modified="2014-10-29" version="1">MTSSVDSTDAKFFVRSFIRFLSGQIEQPNFNEDSRESIEVAIQCLENVYELNDESAGEAESNVKKEKENDDPRNHIDLYEMYRNTFVVVTPERKQEAEGLKNDGNRLMKEEKYQEALNTYSKAINLDATNPVFYCNRAAAYSRLGDYSRAADDCRMALRHDPNYSKAWGRLGLAYSKMNQHQQAITAYQNAIRLEPDNQDYKNNLSVSQQHLAEPPRNPAASGGIPEGLDLGAVLNNPDLVRMAASMMGDPSIQNMLGQLGGMNNMDALLDTGRRLAQEMSSQNPDLFTNVLRQMEQAGVNLQRNNPPNPDGSGNPPQPPPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT17</accession>
    <name>A0A084VT17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008570</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008570-RA">
        <property type="protein sequence ID" value="ASIC008570-PA"/>
        <property type="gene ID" value="ASIC008570"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008570"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008570-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7672" checksum="44E2679814F65E3B" modified="2014-10-29" version="1">MRECNAELYGAGCTHSEQDEVQTITERRRCMRAEGNHWRTRGHVSNAFASREWSSTSLSTVYYACIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTA6</accession>
    <name>A0A084VTA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-patch_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008764</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTA6"/>
    <dbReference type="STRING" id="74873.A0A084VTA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008764-RA">
        <property type="protein sequence ID" value="ASIC008764-PA"/>
        <property type="gene ID" value="ASIC008764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008764"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013215"/>
    <dbReference type="OMA" id="HELVITM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="4">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB41200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="31066" checksum="3150F701CEFBFBD3" modified="2014-10-29" version="1">MDSKKISFGFAKVNKKQPLQAGPAASVPLKSKDDSIQMIECLEGQSIKVIGKTDEPPPPLVIPLREQDKTTVPDRLAKLLGIRQEKQGRLQATESKQPSTESNTNGGSVGSEKCEVKIKQEPSDDGAATVTETLEQRAAREILNDINQANVKKEEQNNFVVPLLPEELPLDGARESSMDDYESVPIEKFGLAMLRGMGYKDDPKKDSAKAERPDFGPVMRPKGLGLGADRAMKAKAANAPLIPPAQGEILTMKQGAQIKVLAGKHKDAYGTFCGSSQISAGSLAKFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTD1</accession>
    <name>A0A084VTD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Epithelial chloride channel protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008841</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016342">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTD1"/>
    <dbReference type="STRING" id="74873.A0A084VTD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008841-RA">
        <property type="protein sequence ID" value="ASIC008841-PA"/>
        <property type="gene ID" value="ASIC008841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008841"/>
    <dbReference type="OrthoDB" id="8197001at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759889" evidence="1">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008841-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="187" mass="20021" checksum="48E6D72CA7AA3AD6" modified="2014-10-29" version="1">MARTLAFPLPLLLVAAMLGLGVPLANGASSITVEKSAYKNVVIEIRDNVPVDNCQTILQNLETDCTKNVNSHLSYNVDLCPGVRLVAYGAASVIRPPFGGTSVPSVPDHHTCHIPPNARDTNECVARSNGNVIPTNRGQVAIIGVWDGREAHFRCDTKPEARCKSTGISLEHARRRCTIAASGFPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTH2</accession>
    <name>A0A084VTH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Thermonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008857</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008857-RA">
        <property type="protein sequence ID" value="ASIC008857-PA"/>
        <property type="gene ID" value="ASIC008857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008857"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759895" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7111" checksum="9D9597932CC327F8" modified="2014-10-29" version="1">MRAIFILLSVLAAVLFASAAKVVQTGNTVVVSEVRGRTGNARLLFKDAPSATRAAASLRSELLKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU24</accession>
    <name>A0A084VU24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycoside hydrolase, family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009059</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009059-RA">
        <property type="protein sequence ID" value="ASIC009059-PA"/>
        <property type="gene ID" value="ASIC009059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009059"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009059-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="16029" checksum="5499162701F8AEAB" modified="2014-10-29" version="1">MIERGQKDPRPFSVVHTHTWLCPLLHLRPQSQYQRATQLDVSCRPFWSAAYIAAFRSIMRGKKVERCVRSDSINGGPRCSIIRYRMRGSVRTQPLPEHVVALASILHVVCNCMLLQHNSRRSLRSTKTGATVFNYFNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUK6</accession>
    <name>A0A084VUK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">KIAA0597 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009281</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525136">
        <property type="protein sequence ID" value="KFB41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009281-RA">
        <property type="protein sequence ID" value="ASIC009281-PA"/>
        <property type="gene ID" value="ASIC009281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009281"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10912" checksum="C5BA2C33C469EB99" modified="2014-10-29" version="1">MEEEFCVLLEVLFGPSTFPSSVIALCRPPRSCLTAAAADVMLLAEEDDCEDIICVEDELSTCLVVVLVEELEDEDCLEVLLLLRLLLSKCCENEKSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVC2</accession>
    <name>A0A084VVC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP000686-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009477</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VVC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009477-RA">
        <property type="protein sequence ID" value="ASIC009477-PA"/>
        <property type="gene ID" value="ASIC009477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009477"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021859"/>
    <dbReference type="OMA" id="YAQFMES"/>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000018">
        <property type="entry name" value="Reduced mechanoreceptor potential A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000024">
        <property type="entry name" value="Reduced mechanoreceptor potential A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000839">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="6">
        <location>
            <begin position="3"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="7">
        <location>
            <begin position="438"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="9">
        <location>
            <begin position="835"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168916" checksum="C53AD8BFB70A5F2F" modified="2014-10-29" version="1">MTLYFDTKVQFLDSEAISTVSSWHAVEPIFAVASYSNERGGSVTIFDDTGIPLRDVTFPVHPTSQATVLTWHPERKILLTGWENGEIHAWFEGKRDFATVNGPHKSPIMLLEFSEKGGRVITADAMGVLTGWRFDGQSQFLTMFNHDLRDPLLHITFRRSIQSASSKELTNLARAAVAGDEAALDQLTSWRPRTAVRNLAHASLQDNYCFYACTQAGILYYISQTGTCTEIVRGDSIPITQILWHPKQDSIVILMEDITIGHYEVDASGQITELDRVKLAGKVSGSKSAITWVAGCALAILTGDLSVRIWDIETNDNYVLTMELPTASGEEGSGRLPASAMEVFTCVAYCRDTHTLSAGTSQGNLYTWRRMSGAYGRVFASAHEAGWQLTNVTPVRGTIKSLTWGTTDSNRPCMMVNCLSNVFILKEQALLARHTRTVWATQRKSNELLLRHASGRETVLRTDSSIIHLALNELHIVVTNGRSIGVYRIQQPLLHGNVGDTLGTAGRSGLSEAGDGSADEHDPNALLATFVCSFAVDCVAIYLYEQNIVALGVEQVKIFSLSGVNLHEIVFNDNEGKPIGVDLLGPFLTIFTLNGFIKLYDVSRHDIKLLLPPKCAYDMFESFGEIIHAKANATGTHVALTIANEQLVPDGRLHLWNLETHVISPCEFRSASTAVERQQLNGRVRWAGKEETGSTTTTSEDSGMGQCLPVGFYWDTDDARLLACETKPLPKHQQQQQTLSGPRASQPVSQIHVMFVDAQRSELKQLEVVEASATGSGESPSGEQQLISLCVPHLVVLKRNEIVRLPLRDFKGLETCDLATRGMVLNFSLNVAQENMDQAFSCIRSLRSDTVWMNLARLCVQTGRLDVARVCLGHLRRARSVRALRRAMEDDTLEQEARVAVLAIELDMVSEAEALYKRCGRYDLLNKLYQASGRFDEALEVAEHFDRVHLRNTYHRYAEWLKENGKTQKAIQYYERTSSLMHNISQLLIDDPVALKKYMQQTTDPELLRWWAQYVESSGDMEGAFKIYQRSEDWFAQVRILCFIGQVGRADEIARTSGDRAACYHLGRYYENSGKFAEAIGFYTRAQTYGNAVRICKENDLQDDLWTVACTARARDKASAAAYFEEAGDYRRAVELYHRAGMLHKAVEMAFKSQQPESLQVIASELDATSDPELVARCADFFVGIEQPYKAVQLLANTRQLQAALAVCAEHRVPLTESLAEALTPAKDTDGLAEGERVAILLRLGEILQEQGDYHSATKKFTQAGDKVRAMKSLLKSGDTDKIIFFAGMSRHKEVYVMAANYLQALNWQNDAKILKNIVTFYTKGQAYSQLANFYANCAQAEIDEFRDYDKALNALQEAAKCLARSVPPSAPAVLDTLHQAMAEVRRVIELQDATERREYANVIKLIKVRLEDPQQPAEPQPPVRIWDLLTLLVECLVATGQHTEALHYVRELAQRKPDWYHQELLDKAVLDRLVAETGVNLEPYVNVAKVKRPATATISSMSDDEEIQEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVS5</accession>
    <name>A0A084VVS5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP000876-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00009653</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017221">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVS5"/>
    <dbReference type="STRING" id="74873.A0A084VVS5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009653-RA">
        <property type="protein sequence ID" value="ASIC009653-PA"/>
        <property type="gene ID" value="ASIC009653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009653"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001227"/>
    <dbReference type="OMA" id="GFKHEPY"/>
    <dbReference type="OrthoDB" id="5976910at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19744">
        <property type="entry name" value="bHLH_TS_dAS-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF153">
        <property type="entry name" value="ACHAETE-SCUTE FAMILY BHLH TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="336" mass="35661" checksum="D445E4858F1FDDD2" modified="2014-10-29" version="1">MAAVVRSVALGQNIHNIMPGGLVVGHGPLQPKPLAVLPGNGVLLGKRPIAPAPSMLVHPDGSMQLGSKPQQQQQVTGAVLLEHRPKGAGGVGPVSTAGKKYAYGGLPYATPQQSASVQRRNARERNRVKQVNNGFANLRQHIPPTVVTALTNGTRATNKKLSKVDTLRLAVEYIRSLERMLEDNGGEQPTVGVTGATNNGAPAAATNTNQLSNSSVCSSGSTYYGTMSEPSNASSPAPSHLSENSSQRGTPGCYTQISGGFKHEPYDIYIDPANSPTPSYGSDHGIAGVGVHHHTHLHPSSTTELYDDSPYDEDLSPQNPYDEELLDVISWWQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW58</accession>
    <name>A0A084VW58_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009904</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525170">
        <property type="protein sequence ID" value="KFB42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009904-RA">
        <property type="protein sequence ID" value="ASIC009904-PA"/>
        <property type="gene ID" value="ASIC009904"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009904"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009904-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7151" checksum="4340A5C7C65FB7F4" modified="2014-10-29" version="1">MHEEKPFGPDAIQCGSVCWALIEMHSQMMHLHVDLGSMMGFTAEYDAASGSGQGVQAKPNRKSQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW89</accession>
    <name>A0A084VW89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003785-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW89"/>
    <dbReference type="STRING" id="74873.A0A084VW89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009910-RA">
        <property type="protein sequence ID" value="ASIC009910-PA"/>
        <property type="gene ID" value="ASIC009910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009910"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017809"/>
    <dbReference type="OMA" id="ENHIQPA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="476" mass="53909" checksum="2F7DF120B61CC480" modified="2014-10-29" version="1">MLYIRGNRRDYDRWKDLGNPEWGWEDVLEYFKKSENMNVPELVRGNGSRYHRTGGYLNVEQARTDPVLNQLLRQAAVELKKEWIPDFNRDRHVGYGSSQLTIIGATRFSPAKAFLSPIKNRFNLHVIKNAMVEKILIDERNVATGVSFVLQNKIRMNAVANKEVIVAAGAINTPQLLMLSGIGRTEELEKFDIPTKANLNVGGKLQDHVAVPLFFKFPALQQDASELFLAFNEIDSLYEYTLKNRSQGVGNMQYLDTMVFLNTVNATDRYPDAQVFNMGAQKGADFIGRLASNFEYIKPIRDSLEEAAREAPVIYTHITTLNPKSRGKVRLASADPRVHPLIEANYFDHEDDLQTLVRGIRQLQELLKTTAFRTNKGELHRVNIPGCQQLEYDTDEYWECYVRHMTITTYHPVGTAKMGPSTDPEAVVDSRLRVKGIRGLRVIDASIMPLIVSGNTNAPTIMIGEMGSDFIKQENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWW1</accession>
    <name>A0A084VWW1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00010156</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWW1"/>
    <dbReference type="STRING" id="74873.A0A084VWW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010156-RA">
        <property type="protein sequence ID" value="ASIC010156-PA"/>
        <property type="gene ID" value="ASIC010156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010156"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014080"/>
    <dbReference type="OMA" id="WFMSSFL"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB42455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010156-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="287" mass="32082" checksum="E37E318AEB7122D0" modified="2014-10-29" version="1">MMLRILNRTSRLVAPGVRAFSSEAAGQQKALVITEVDDKTGYATVTLNRPPVNSLNLELLTAISETLDDLQNNKSRGMILTSSSNTVFSAGLDIMEMYKPNQDRLREFWSTLQDVWFKLYGSPFATVAAINGHAPAGGCLLSLCCEYRIMCPNYTIGLNETQLGIVAPTWFQASLRNTISRRESELALTLGKMYTTEEALKVGMIDEIAESKEKALERATNFLNLFRKISPVARAMTKQALRSKDIVELEDNRTQDIDLFVYAVNQPMVQKGLEVYLENLKKKAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX61</accession>
    <name>A0A084VX61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP000413-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00010266</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX61"/>
    <dbReference type="STRING" id="74873.A0A084VX61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010266-RA">
        <property type="protein sequence ID" value="ASIC010266-PA"/>
        <property type="gene ID" value="ASIC010266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010266"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009412"/>
    <dbReference type="OMA" id="PLFMIAW"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="OSMotic avoidance abnormal family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000185">
        <property type="entry name" value="OSMotic avoidance abnormal family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <end position="567"/>
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            <begin position="574"/>
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    </feature>
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            <begin position="642"/>
            <end position="669"/>
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            <begin position="173"/>
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        </location>
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        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
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        <location>
            <begin position="521"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="431"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="825"/>
            <end position="886"/>
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    </feature>
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        <location>
            <begin position="1070"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="825"/>
            <end position="851"/>
        </location>
    </feature>
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        <location>
            <begin position="1094"/>
            <end position="1110"/>
        </location>
    </feature>
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            <begin position="1138"/>
            <end position="1150"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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            <dbReference type="EMBL" id="KFB42555.1"/>
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    </evidence>
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    <sequence length="1193" mass="130580" checksum="3B499EEF18FA1AC7" modified="2014-10-29" version="1">MVHLDPLRLCRKKRKIPQGGAILDQVISQSASASNQCLLYKMANYKRGGDLIDAFQIGGQKAVEQLIREQFGVFMYNKGRGQIINRAEYLRWKYMDNHEVIIPIEASLSPHDPLSKWVDHKACWQMQYRGLLGESLLHVLIICDTKVHTKLARILLRVFPEQAIDVMEGEEYLGASALHLAIAYSNNELVGDLIDAGADVSQRATGRFFLPRDQQGLRPVKTTDYEGLAYLGEYPLAWAACCANESVYNLLLECGADPNAQDSFGNMILHMVVVCDKLDMFGYALRHPKLPCKNGIVNAAGLTPLTLACRLGRDEVFREMLELSAREFWRYSNITCSGYPLNALDTLMPDGSTNWNSALFIILNGTKEEHLNMLDGGIVERLLDEKWKTFARNQFLKRLLILAIHLFCLSCSVYLRPVRIFDDDDAGSDDAGATDGEAGGAAGNSGEEEDRGGDGGDADPIDLSTWVRYGFEVATVMGVLSYVVLQQGDEIKNQGFFSFLKSLGQAPAKAIFLISNILILACIPLRIMGDTETEEAILLFAVPGSWFLLMFFAGAIGLTGPFVTMIFSMITGDMFTFGIIYMIVLFGFSQAFFFLYKGHPNAEDSPFGSYFGTWMALFQTTLGDYDYADLNLTTYPNLAKTVFVIFMIFVPILLLNMLIAMMGNTYAYVIEQAEKEGMKQWAKIVVNLERAVTQDDAKRYLEEYSIGLGPSDDPRYETRGVMVIKSKSKTRARQRKGAVSNWKSVLRVTLNELKKRDMTGEELRRIMWGRSSITSPAKIAKKKRPGEDDLSDPFAITAAIDVMSFTQDIVMVSTETVVVPMAPVAPPTTGSRPAPSVPPTATSTSATMFAPHAGGASAPRSAPIAPTATGTGGAPPRRHSTASAPAAMGLGAEAKADYRDPLRELVMISESTSVDENYAQNVKTLAIDASTLDHNPKDIVDPVREREFLKTLEALEDTDSEAGEKPVLGKISLIRRAKSAVSRSTSRKRKTDQHPLFMIAWEDKGGPADLMPSMLPYTDDALLHHHHQQTHTSAHTGEAGDGAVAGDAALHADEPDNDAVTVEELHRRMEQFHQRSRASSVRERDVNSSESSGKHGKARKPAHGRGKHNKISPDNSNESIGGGSGGKPDKRMKSAPILGGGGGGGAGGSGAAVRHGGARGETGTSSPPDPLEPWSTKNIMNINRLLDQDTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXJ7</accession>
    <name>A0A084VXJ7_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP005277-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ZHAS_00010429</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC010429-PA"/>
        <property type="gene ID" value="ASIC010429"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="27"/>
            <end position="321"/>
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            <begin position="32"/>
            <end position="113"/>
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            <begin position="32"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="321" mass="35032" checksum="EC128392E0E5ACF1" modified="2014-10-29" version="1">MAPSRPRFSVGVMAMCCGFLSLTVVAREANPGLSSSLSPVQQQMHPGASALVGGDSPTRATTPLPLGTSSASGDSKRHRKTRETFPLSRPTNHGEDVETRPETTEHATRHRRMEPKMDSLPSRLVFMPSRGRRYGGFSIPTEKRQLTIEQMLEKGDYFVPNRGKKSPTAGSSGGNELMIKKGKFDVLLGSGAPDEYFFPNRGKKEYFVAYEPLAASVSGGKFASAGFAGEVRHPSESRLRRNLLENLANEHKDTFFSSRGKRFLPAPDGLMLWPGEALPVEGREVLPDDGTAAGEDFSDQPGDMLWNDAMPLFPLDRTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXW1</accession>
    <name>A0A084VXW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002532-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010555</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXW1"/>
    <dbReference type="STRING" id="74873.A0A084VXW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010555-RA">
        <property type="protein sequence ID" value="ASIC010555-PA"/>
        <property type="gene ID" value="ASIC010555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010555"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018133"/>
    <dbReference type="OrthoDB" id="285802at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="18491" checksum="484663779BBFDAA6" modified="2014-10-29" version="1">MDDFMTASSATEMSEASFAGFKREIIESSLEYLDVTLGHPKMSNVRPSKLAAACVAAARCLTPNVRAWNNHLTSVTGYNYQQIHGICSVLVFDLKPLSTSPTLKVSTRKRSVTDSAYLSKSEDDSNTSDDDSCSSCSTCSSVESTSQTCSNSSGSESGETCAKRQRVSVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYG9</accession>
    <name>A0A084VYG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Pita</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00010685</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYG9"/>
    <dbReference type="STRING" id="74873.A0A084VYG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010685-RA">
        <property type="protein sequence ID" value="ASIC010685-PA"/>
        <property type="gene ID" value="ASIC010685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010685"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020203"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020311"/>
    <dbReference type="OMA" id="ENCRILM"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="674"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="769"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010685-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="988" mass="109596" checksum="BBB1AD96F61FD4DF" modified="2014-10-29" version="1">MDQSGDRTLIAVDVVDEALRPQQLKAKQICRLCLAQDVPLSSIFAPQGGPNRTPQTPLSLQITACVSIEANLKDLQHKASPRVNTTINIINSAAGGEAENNRERKINIIKLSPTDLKNLKLSQRIGTPGYQGTPPAGGMKRDQSVVSVSTPLLTSTPMPKRGPPTKAPNQHQGVRLQYDDEQKPPPPVQQNNQPPPKKEVKSPVILNRLASMASKRQNVKEEFVTTGDGTVEMILQFEPEPVESAEQEKIFPCAECPRTFKLKQLLDLHKLNHKRERNFPCGECDKRFFSKYDLAKHMATHTGERPYVCVICRAAFSRSTLLTRHQALHKDDLTYPCMFCERVFVSQKELDKHAQNHEKNRPFVCMHCPKSFAYKQGLERHAAVHAKDLPHKCEYCDMSFHTSAALSRHLTAHAGSRPYPCRLCSKSFMLSHHLSRHLRAHNTVGQSEYKCNDCKQSFNGKNELIAHSESHAKETLVCPLCREPFGDIGEVIEHIHEHAKGSQYACDYCDLLYTSEQKLNAHCQQEHADELACEWSEEQQRQLKEEQAASRKDDAANQPKAEVEGNRSGEELKTDLVLESEIPEIENIFLEPDDYDTAIFMEPEGDEQVIETFEVSEYVEETPSPAAVAATVKPKVSPQTKQPKEVKQEHLSPVPKSKDIYRQKSMDEFYKRNQQAVEKKTAQRNVSEMLKNLPKGVTIKREQSAPALTTNPPKKAPPQPIVVEKKQPPIVIPIAKDKVSPVQGSSKGSSAQAVAEPKRRPGRPPKIVPKVEESEGKKENVAIKKVEQSEVVRKQERKQQLTKLDEESGKKELPERKSTVEGGLKRSGTMNFPKTRVGIDVPPKTFPGASGASGNKGSVSMVRRSYAVPPSKEPTVGMKRPADKESPTDEPVSSKRFAPGPQRKTLNPAMLSTMGNTTQKSAGTAKATEPVPVTVVRTVKRAANADAPVGAPVEMNVGGKTVKLQKLILSKSEALALQKAGKLGKGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYL7</accession>
    <name>A0A084VYL7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00010738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01018378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYL7"/>
    <dbReference type="STRING" id="74873.A0A084VYL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010738-RA">
        <property type="protein sequence ID" value="ASIC010738-PA"/>
        <property type="gene ID" value="ASIC010738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010738"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008040"/>
    <dbReference type="OMA" id="LWRCRAD"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="310" mass="34480" checksum="5D2BB188C27BD9ED" modified="2014-10-29" version="1">MASYKVEQLPSPLSVLGEGPHWDVERQSLYYNDIYGGSIHRYDYAENKTYNATVDGFPVISFIIPVKGNERHFIIGTDRKVTLVDWDGRSEKATFVRTVGEVEPDLLDNRFNDAKVDSRGRFYGGTMRLEAKGDIFEMRLGTFYRYDAKLGKFVTLKQKIGVSNGLCWNDAENLFYYIDSCDLDVKEYRVDENGDLSNERVVIDFRVNGEKPAFVPDGMTIDANGSLYVATFGGSTVYKVNSKTGEVELEIKLPCEQVTSAAFGGPNLDILYVTTAAKEFKTPQPAPAGALFAVTGLGVKGTPMYPVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZB0</accession>
    <name>A0A084VZB0_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP002967-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525245">
        <property type="protein sequence ID" value="KFB43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZB0"/>
    <dbReference type="STRING" id="74873.A0A084VZB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011101-RA">
        <property type="protein sequence ID" value="ASIC011101-PA"/>
        <property type="gene ID" value="ASIC011101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007079"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
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        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="186" mass="19339" checksum="8C03746BEF624EDE" modified="2014-10-29" version="1">MSEKLPESPAEMLALPHVTKANFEKYGKQLLEITQNYAAEKLCLLMDTQEEQEEAVGRRDPFELSDGDSSGVDEAADGTDWGSLAREASQANTSGRGSGGYKRKRSWGTGAAGNARTKKFRKGTGRRKSAAKSTPARKTAASTTKRGAGGAAGSSSRGGRGRGGGSRAPPRDGGGGFGLLPMPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W090</accession>
    <name>A0A084W090_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AGAP001113-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00011576</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W090"/>
    <dbReference type="STRING" id="74873.A0A084W090"/>
    <dbReference type="MEROPS" id="M12.A05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011576-RA">
        <property type="protein sequence ID" value="ASIC011576-PA"/>
        <property type="gene ID" value="ASIC011576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011576"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006149"/>
    <dbReference type="OMA" id="DQCQPVR"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784365" evidence="18">
        <location>
            <begin position="22"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="19">
        <location>
            <begin position="282"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="968"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="389"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="406"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="594"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="598"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB43634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116605" checksum="3D61DDE4661D3E17" modified="2014-10-29" version="1">MISSIPSHIVIISLFILTADSTHQGLYTHHLKTAKLVVPRKVNHLGETVSHVLTHHHETGIRSTIHEDHKRLRRNAPRHFPSQLHYHLDIDEDTLHLELEPSTASFVAPLMVVERHRRDVRTRVRPTEHINCHYQGQVRGHDQSRVALSACNGLTGVLRTNRSEYWIEPSKNHLVGPNGEHPHVLFKRADVKETPSTSKVRSTNKPKRKRKRKKRHLTNCGTREPRRLTETRLEWQHQGKVLVQGGRKARNHGDLFFGDVDFPKNSGRRNNRRTKRSISKPRHVEALVVADHSMVQFHQDVDLQQYLLMIMNMVSSLYKDPTIGNSIQVTVVKIIILEEEHSHADFNITHMAGNTLENFCRWQRNLNPKPDEDPHHHDVAILVTRKNICSNHGCATLGVANVGGMCRPDKSCSVNEDNGITLAHTISHELGHNFGMYHDTAKTGCDHRIGPILHIMTPSFEADTMQVSWSNCSRRDITHFLDQGLGKCLEDPPSQEEYEYPELPPGAMYNADLQCRLQFNSTDEEMTVCSKLDEICTQLWCLVGDVCTTMLRPAAPGTNCGRRMWCQNQQCVDVEELPSPVDGGWGDWSPWSDCSRSCGVGIAKQTRECDHPSPAHGGSFCIGERARYKTCHVQPCPFGTPSFRAEQCSAHDNDLIKGEKYSWLPYFDKNEPCELYCSNAEDTMIVPFGDTAADGTLCNLGTNDMCIGGICRRVGCDWVVDSNTTEDRCGICGGVGDTCFVKKGEIIRKINTTDGMHDVLLIPVGARNVLIEETAPSKNFIGVGSVTGTECYLNCNHFIQLPGEYEVASSLCLYERENEQERLKIPGPIMEDIYVYIIIKKKNNHVAIRYEYTLPSNINKNQSTYYWKLSDWSVCTATCGGGKQSRESVCYHRGKGMVKEELCLRHAFGKRHEQITRDCNDDPCPFNWWIGPWQLCPMTCRKSGETVAPIRRRSILCVDSNSNARPDVHCNNKPRPHDSEPCGDELPLCQEPAKQRSNPETERPDTVTPEEILSPDLPSPSTPNDYEISNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0D6</accession>
    <name>A0A084W0D6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP001190-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00011408</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0D6"/>
    <dbReference type="STRING" id="74873.A0A084W0D6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011408-RA">
        <property type="protein sequence ID" value="ASIC011408-PA"/>
        <property type="gene ID" value="ASIC011408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011408"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021898"/>
    <dbReference type="OMA" id="CASPWRP"/>
    <dbReference type="OrthoDB" id="10061449at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="274" mass="30101" checksum="32054FA24AD12DE8" modified="2014-10-29" version="1">MSTLLSSRQCVINECSDTVNRIIGGEEAVPHELPYQVSLQWNYNDDSTKPMHFCGGALLSDRWIVTAAHCKTSYTDDGFIEAVAGAHDIADPLEDNQRRKVEDMMVHTQYCGTVCPNDIALIQVVMPFILGDHVKPIRLPQAKEVFHGDALVSGWGATTPALVPEYPDKLRKVVLPLVDYDECRQLWYEVSHLANTNVCAGPEDGSKAACSADSGGPLVTLNGTQVSTDPVLIGIVSWGPFPCASPWRPNVFTGIAYFIDWIEEHMKQGLIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E4</accession>
    <name>A0A084W0E4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011418</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011418-RA">
        <property type="protein sequence ID" value="ASIC011418-PA"/>
        <property type="gene ID" value="ASIC011418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011418"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011418-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9759" checksum="7F242BE98E3C04CF" modified="2014-10-29" version="1">METFLAIKYRDFALCPTSSSPDDGAEYRTLAGTIDVRQHDDDDGDDCDKNVVSAFSGTPFTVHLDILRRLNKDTSAMAAVRLMMLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1E3</accession>
    <name>A0A084W1E3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011867</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525267">
        <property type="protein sequence ID" value="KFB44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1E3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011867-RA">
        <property type="protein sequence ID" value="ASIC011867-PA"/>
        <property type="gene ID" value="ASIC011867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011867"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12406" checksum="A4A038BE5F0B59D8" modified="2014-10-29" version="1">MDASQPRRKQQSVALAAINSIYHVKPCSYIVLYHGLVLLSGHIESNGSSNRQKHRPSSTSSSNRLTLVCGIAVKSVLPFVRETDSDFIRQRLHSIWKPEEKCGDARNFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Y6</accession>
    <name>A0A084W1Y6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PAT1 homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1Y6"/>
    <dbReference type="STRING" id="74873.A0A084W1Y6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012123-RA">
        <property type="protein sequence ID" value="ASIC012123-PA"/>
        <property type="gene ID" value="ASIC012123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012123"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011900"/>
    <dbReference type="OMA" id="TIIFQME"/>
    <dbReference type="OrthoDB" id="8251691at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="105100" checksum="36DDE57183866C80" modified="2014-10-29" version="1">MDSFFGFDTTLSVVSNKESVDAGDGKRSRSSPCYFKEEESDEEEYDALNDETFGAADKGDWEHIHENLVRLESGAKEEDDALSSELDDGHSQHQLLFDDYDLDLKFNFYDTNDESGRSSAGAQSIGDEFASKLRLDPSIWDSPVKVPAHHLHHQPVTAGFPQTAAIQPRVSSAFQNSSPTPGQPPVSSGLAGAGFPTGLVAPPMKMLSVEDIERNIIEQQRQKLKEHQQTILHQQQQQQQQQKQQQQHKLFAQQQQAILRNQRKHQQTHSTKSRETLPMPKDGPLKMQHGIGMLPSAMNPIGSVVPTPMLNPPQLLPTRNALFPSVPGHSHSAAHLLTQSGRVPLGMLPPPYGLLSAAGQFPGPINNLAMHPAFPHAALGSHGLHGLLAGPGPIPSLGQQQRHPVPPSPFLLQPNASSVQNNQFNQRLVQEIQQNHPLLAFNRQQQQLAGTFNGNSNGSNNNSHTHKHHSGQYMHHHQQQQQYRNSNGMPHKVGSAVEHDEYANLMSNREKQWLIGIQLTQLNSDWPYFSDYYFTVFKERQAALKGESHAANRAYKDNQLNHPFTQPTGHAQLLLMSSMAKSAGMLHARERKSSESKSIAGGSNGVDGKESVRTYTPLQFENSLGKLQCGSVTAPRKIIDMEVMGGEERDANGNGMNMEHSVSQRKTRHVLLLIETLYRIVLKLEDLQNPTAIEAFVLLREKRQRERNLLNADGGTGGCRGTLAELPERDETYDELVAALIGNLSQDKTTSILGVRKGKILLRRSLAVLRKHPFRWTLWAMIFNAIPSLQRKDRDDVDGLLFSLYAEFERHVQCGTVADLLQLSKILGPSSTGDAAMRYLTTSKLLLSAVITIIFQMEILYGKHPRPFNTEEDESSWLAFLLHANRMVCNRLTAKTNGGAPVHGCIRISPNNNIARTLRVHFGRFSDRAIGSDLLDFITDNGNDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W228</accession>
    <name>A0A084W228_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012050</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W228"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012050-RA">
        <property type="protein sequence ID" value="ASIC012050-PA"/>
        <property type="gene ID" value="ASIC012050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012050"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016685"/>
    <dbReference type="OMA" id="CNYLAFA"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="34451" checksum="D558CC6E0B9276E6" modified="2014-10-29" version="1">MPQRYASLPCSSPPKLQDFSGSNDTGGGSLDGGRNKLGIGISAVHDAVLRGMARLPEPILNEHPVTIYPGRASPTRRMPPRTLSGSMERHRFPASDNSTSTSQENSSPENNESEYNESSLSPTHGHLHQLQGGTPVNSLISRIFHQNPNAPPPSSHTPSGPTAGSHRSQRMSASGVPMAGAPSRRTAGRADSDEERFSDDSLEESSLPPPPGPPTVPPPPSLSAPVTPSKRHSIAWEVNLDDPASFGDPLVTAPKSSTTVSSKVRTPTPARNVSECLHYPIVVEPLLGSIIINENLSKPIPDPFWEMVCQRLRDLSSALNEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2L8</accession>
    <name>A0A084W2L8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cilia- and flagella-associated protein 52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00012250</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with BRCA2. Interacts with the CCT chaperonin complex. Interacts with HSP70. Interacts with AK8. Interacts with CFAP45. Interacts with DNAI1. Interacts with IQDC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CFAP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019633">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2L8"/>
    <dbReference type="STRING" id="74873.A0A084W2L8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012250-RA">
        <property type="protein sequence ID" value="ASIC012250-PA"/>
        <property type="gene ID" value="ASIC012250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012250"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006375"/>
    <dbReference type="OMA" id="RIMVYNF"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001835">
        <property type="entry name" value="AGAP005915-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000568">
        <property type="entry name" value="Cilia-and flagella-associated protein 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF14">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="657"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="790" mass="86860" checksum="D1A58AF1CCE45A1A" modified="2014-10-29" version="1">MSIEEPTEVINLEPSAIIGFDGHVVCGLRVHPDQRHLVFPLGNEISIYELATNKQTFLRGHTNTISTLDISTSGRMVASGQSNHMGFRAYVIVWDWESRKEISRYELHRVRVQSLCFSSNDQFLVSLGGKDCGSIIVWDIEQRTAICGTIATKETTGDATKVCSLNKRFTTFVSGGDQNLRVWNIDRERKRLTVQDVAVGKLRREFTGMRISPNDDTLYVGTMSGDIVKINLNCNPNPSVPSQDKMPVLLGCFGKHNARKPPGKDCEKYHYGVRDLLLLPDGKLIIGAGDGTIDLVQERNANFKTYRGPTWPELKSLHSTKIDGVVTSLQIVHGKTLLIGTNGCEIYSLELANFSSSLRLLKTCHTNAVYDIAFPYNFSLVFATASHESIRIWSTSKMQELLRIVVPNFASSSIVFSRDGKSIISAWNDGVIRAFTPLTGKLIYAIPNAHNKGCSSVAVTSNGKIVVSGGIEGQVRVWKIDPYVQSLIGVLKEHYGPIESVHINNYDTEVVSASRDGSCVIWDLIRLTRKHVIFAHTQFIAAQYFPTGVQILTAGSDKLIGYWEAYDGSLVREVEGSKSGPINAIDMNMMGEYFVSAGTDQIVRLWNYQLGVEVAVGIGHASAITSARYSPNGKFLVTGSSDGGIFVWKVPEKFHIKIPDEDTPPTNEQRNSASSTKTTTKPAHNSSSQTGGSRDGSRKTTPLSSGARVAPTSRTRANANENVRLLESSRSNRSSQIAECPAVDPNAQPTIDPCVDTASLADDQEQWETRSQHSSVSQIQLSQEKQQGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2V1</accession>
    <name>A0A084W2V1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diuretic hormone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012424</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019701">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2V1"/>
    <dbReference type="STRING" id="74873.A0A084W2V1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012424-RA">
        <property type="protein sequence ID" value="ASIC012424-PA"/>
        <property type="gene ID" value="ASIC012424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012424"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000305"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021669"/>
    <dbReference type="OMA" id="RINYSHC"/>
    <dbReference type="OrthoDB" id="6022368at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:diuretic hormone receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
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        <property type="term" value="F:peptide hormone binding"/>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="entry name" value="diuretic hormone receptor isoform X1"/>
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        <property type="entry name" value="Uncharacterized protein, isoform B"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_2"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="14">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="145"/>
            <end position="399"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012424-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="526" mass="58992" checksum="2A4A66131150515C" modified="2014-10-29" version="1">MACRKKAKLPEKQRRVPELSAADAQGLVSVSVADYDELSSFPPDLLGEFENNTELECLLRAHQDAQAGTPFDGCPVDFDRILCWPKTEPGTWAVLPCFEEFKGVHYDVTQNVTRYCHPNGRWNNYSNYAACHHDDRATPDIVEISSIIYYTGYIISLVALSLAVIVFVYFKDLRCLRNTIHANLFITYILSALLWIIILTLQLSTGNSSGMTSCVIFVTLLHYFTLTNFFWMLVEGLYLYMLVVETFSGDNLRFNMYAAIGWGGPAIFVMLWAIAKGITLSGQDTTNTLEIECSWMRESLVDWIFQGPVCAVLIINLVFLIRIMWVLITKLRSANTVETRQYRKASKALLVLIPLLGITYLVVLAAPAEGVVSDIFAIARALLLSTQGLSVSLFYCFLNSEVRLALRHRLERWRDERNIRLGQVRQRSRRITYFLLPGKPKSRSREPFPASGCAPLTYSKRESCASSATTTTLLGPHTYPSAMRGSNGALHMQSIAPRAISPLMQVGGKLGQIKHFLQGKANPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W348</accession>
    <name>A0A084W348_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00012528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC012528-PA"/>
        <property type="gene ID" value="ASIC012528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012528"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020363"/>
    <dbReference type="OMA" id="YSGLMWR"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mS33"/>
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        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
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    </dbReference>
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        <property type="entry name" value="MRP-S33"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
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        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="13359" checksum="28DDF2E9FF6BE41B" modified="2014-10-29" version="1">MSKYKELTKLTTTYARRMNYLSNRIFGEVARPTNPQSMKVVKMFSEEPIHKRDYVVNWYPRHVETHLLAMKLREYGLFRDEHQDFKEEMKRLRALRGKAPPKKGEGKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3U4</accession>
    <name>A0A084W3U4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP012916-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012798</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3U4"/>
    <dbReference type="STRING" id="74873.A0A084W3U4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012798-RA">
        <property type="protein sequence ID" value="ASIC012798-PA"/>
        <property type="gene ID" value="ASIC012798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012798"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000837"/>
    <dbReference type="OrthoDB" id="7743108at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012798-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25114" checksum="02BEAAABA446DBB1" modified="2014-10-29" version="1">MISSKLRTLENNLIEIERDLKTREDVIYGTLVGFFQFVQEVADAREQKLSTNVVNLNTKLQKIEANLVELATNISQYKRLSTAMAASEEPYASCLEEPLKKSGKYSIQIGPYKKAITVYCEQTDYGGGWTVLQHRFDGSENFFRNWSDYRDGFGNLDVNSQQSFQTHAIVNSQQSPGISSFSTHATSVNTVSNLPRHKPSPVPRANANVRESVVINQQAKSLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4E2</accession>
    <name>A0A084W4E2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">CoaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013004</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4E2"/>
    <dbReference type="STRING" id="74873.A0A084W4E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013004-RA">
        <property type="protein sequence ID" value="ASIC013004-PA"/>
        <property type="gene ID" value="ASIC013004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013004"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000004">
        <property type="entry name" value="Phosphopantothenoylcysteine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="24409" checksum="63706000559CB898" modified="2014-10-29" version="1">MKVKKNILVGCTGSVATIKLPLLVEQLLKLPDFEIDVRVIVTEHAQHFFSRADLPHGILLYTDQDEWTSWQKRGDPVLHIELGKWADLLLIAPLDANSLAKMANGLCDNLLLCTTRAWDPAKPLLFCPAMNTRMWQHPITATQVETLKSWGHREIPCIAKTLMCGDTGPGAMAEVDTIVATTNETLKAQRASTPRWEYPLDVLLVPFSPSSMYMNNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M3</accession>
    <name>A0A084W4M3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013125</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013125-RA">
        <property type="protein sequence ID" value="ASIC013125-PA"/>
        <property type="gene ID" value="ASIC013125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013125"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="100" mass="10846" checksum="3BDA96B2E081E7B5" modified="2014-10-29" version="1">MDATLALHDFRGPTGNRVFGASHFWRMLPAVPPFGTRPGETGEKCARILAPNWMSIPRCGGGGGGGGGDSYMPFWAKNSSRKMRPSVRQCCLDRGCYVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Q3</accession>
    <name>A0A084W4Q3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein phosphatase 1 regulatory subunit 16A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4Q3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013160-RA">
        <property type="protein sequence ID" value="ASIC013160-PA"/>
        <property type="gene ID" value="ASIC013160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013160"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11471" checksum="C9ED0F5BC50836E7" modified="2014-10-29" version="1">MVNEVINNRKLSDMSPHSGNGAAGKGSRIVGEILAVVYMVSRLGWPPVSVASAWDQIRVENLSCFRGSHLYDRSVVKSASMRTAGEETPASEPAARCGFLLPIAIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6D8</accession>
    <name>A0A084W6D8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006859-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013758</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6D8"/>
    <dbReference type="STRING" id="74873.A0A084W6D8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013758-RA">
        <property type="protein sequence ID" value="ASIC013758-PA"/>
        <property type="gene ID" value="ASIC013758"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013758"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000185"/>
    <dbReference type="OMA" id="HTHHGAK"/>
    <dbReference type="OrthoDB" id="6382835at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784539" evidence="4">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013758-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14506" checksum="47C24D8ED12AA579" modified="2014-10-29" version="1">MMKITIATLALFAVVVFGYEHEHHDYHSHPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLHEADGTERVVEYSSDKHNGFQAHVKRVGHASHPEVYGHHEEGHSYGGHGHGHASSYAKLSQHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Q3</accession>
    <name>A0A084W6Q3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Q3"/>
    <dbReference type="STRING" id="74873.A0A084W6Q3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013860-RA">
        <property type="protein sequence ID" value="ASIC013860-PA"/>
        <property type="gene ID" value="ASIC013860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013860"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004931"/>
    <dbReference type="OMA" id="TSICNER"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="592" mass="60686" checksum="D65A613EC03A4538" modified="2014-10-29" version="1">MATIMSHNLPLIPLPLKAGAALAKAGLMMPGAALLGSLADGGLRKGTPPDLEQRGPAGDGISPKTNVGGEEDDGHESDRMSCCSDDSELSVGQEVPDDLRASSRTLVPSATLVSPLVEEMSNDSSRYSKDTPSELDFMQRLQQPAGSTVMLRPSPTRLHEEFLRSSQLYAEELMRQQMQIVAAARGLAVSPSKVGVSPDLGGSGGGLAAATRHLQDLQRGRSPPAEAAKLGFRPARGIPLALGDLYRQEASSPGDAGGASSGGSFRGIHSHLSAISQITQNLNSDLSKLTSPTTFAGGSRTSRESSQSPPTPPTLGNHLHQLHQHHLQQQQQQQQQHHHHQQQQQAQQHHHQLALAALNNNIAVALNDQSLKFSIDNILKADFGRRITDPLLLKRTSKSGHPSPLQQAQQQQHHVPSGAGRKPSSKSPSAIDLSGGVGPDSGLLPSLAGVKGFCTSASVHSSSRASSGSVSSVGSSVGSSEDVVSPVSPLSSTGSLKGGDAPPAGGGASGSGGGGGGGASGSGASGSGASGGGGASSSGSSGGSSSSGGPMVWPAWVYCTRYSDRPSSGPFVTCVFFWISRHSCGQSETTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7T3</accession>
    <name>A0A084W7T3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00014262</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7T3"/>
    <dbReference type="STRING" id="74873.A0A084W7T3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014262-RA">
        <property type="protein sequence ID" value="ASIC014262-PA"/>
        <property type="gene ID" value="ASIC014262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014262"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022411"/>
    <dbReference type="OMA" id="KQPPDAQ"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="16">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="94"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014262-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="352" mass="39984" checksum="96F157307311EA78" modified="2014-10-29" version="1">MSNSLNTAKKKYSQQELRRIMTETKAAKQQQHSESGVKRIDSPLAKYPLQNIFCDFLNSNLTCALCRSIVRSEAVWKVHINSKQHKENVELAKQLKEQPTPSTLPIRGPTISSNQSDNSLKRPGTSVTTEDCIPTKKPKGILKNSQMQSDQNATLPSDFFDSKQNGQTRNKNTSTIRKDLVNIRLPDKHQQQSSEAMEQDPAAMDGGTVAPSDEEKLPEGFFDDPKMDAKARNQEYKDPDDEEWEKFQKEIKEATNVSLAIISEEQEESTAERQIAEIDEQIRNWSRVLSLEKKKEQVQTLKGISSSSRLNGKQDGSLRITSRVETAGDDDEDDDDEEFDEFLDWRAKKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7V1</accession>
    <name>A0A084W7V1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014282</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7V1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014282-RA">
        <property type="protein sequence ID" value="ASIC014282-PA"/>
        <property type="gene ID" value="ASIC014282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014282"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="216" mass="24166" checksum="FB244969D07A3D89" modified="2014-10-29" version="1">MHKTVYQWMADAWSAKRWKSRFRHAPSSSNYILLASGAVKSQAKHIHTQTHTHVLVARCPDKHPTHHRSKAGRSPPQTDQTPKSQSWIDSWIIPKGTHHQCATAGARFGRSCGRTVASMIQRGKPACTLEVNTPARTTTSVRSRCFALATKLPWKSTIVCSVRRNNRDHRRVSTVLAFLAPGFRPDDAGVVKFTPRFYPFLQPHAASPSLADNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W892</accession>
    <name>A0A084W892_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">PilT protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W892"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014436-RA">
        <property type="protein sequence ID" value="ASIC014436-PA"/>
        <property type="gene ID" value="ASIC014436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014436"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="11210" checksum="E207B5C504FF2AD0" modified="2014-10-29" version="1">MSSTGTSTTVAAWTNTWQHLMLASVGLLALLVSGGIPGGTNVLVAAEGNIGMGNGSTITIGDVLQGRLPSSTTRKAGSSTIPAVLQKGITINGKKVFPFALSRAVRWTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8E0</accession>
    <name>A0A084W8E0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014471</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8E0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014471-RA">
        <property type="protein sequence ID" value="ASIC014471-PA"/>
        <property type="gene ID" value="ASIC014471"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014471"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014471-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7270" checksum="3047E88FEFDB985A" modified="2014-10-29" version="1">MSISTEIQRISLRVTLISEGHSPTKRNGIPIRYRSKAQMSSCGLISTGQLMSQKASHTGTFDYRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Y8</accession>
    <name>A0A084W8Y8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Acyltransferase (Predicted)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014744</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021539">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8Y8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014744-RA">
        <property type="protein sequence ID" value="ASIC014744-PA"/>
        <property type="gene ID" value="ASIC014744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014744"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="10765" checksum="00FE4F9EC35C1E22" modified="2014-10-29" version="1">MKERGQESGGSILAAILGNTTAENADGGPLELLYASVRNSIATTLHNGSGNAASALLLPGVIRGSGLPPPPPPEQNHQQCTDAISTFLSCTANRSTIISGTMMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9M7</accession>
    <name>A0A084W9M7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00014931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01021841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9M7"/>
    <dbReference type="STRING" id="74873.A0A084W9M7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014931-RA">
        <property type="protein sequence ID" value="ASIC014931-PA"/>
        <property type="gene ID" value="ASIC014931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014931"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009959"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB46921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="211" mass="24264" checksum="CB4CDCA9E6506750" modified="2014-10-29" version="1">MSEQQHKRGVFIVFEGCDRAGKTTQCKQLVNKLNDAGHSAQFMNFPDRTTQCGQLINGYLTRKDDFTDEGIHLMFTLNRWEKMKEMEKLLRSGVHLIVDRYSFSGVAFSAAKGLDMEWCKAPEAGLLKPDLVVLLTLSPEAIAKRGGFGDERYEVAEFQKRVMEKYAMLKDDQYWLEVDADKKFEDLTMDLYKITTDTIHNSESKTLGKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9X8</accession>
    <name>A0A084W9X8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP007018-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00015037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9X8"/>
    <dbReference type="STRING" id="74873.A0A084W9X8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015037-RA">
        <property type="protein sequence ID" value="ASIC015037-PA"/>
        <property type="gene ID" value="ASIC015037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001453"/>
    <dbReference type="OMA" id="MQENEAQ"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="484" mass="53762" checksum="D12C1B5406FF1BBA" modified="2014-10-29" version="1">MHHEEFEITTVPMESTTILTTSGSAKRDVRDLAREANFQAKLLMQENEAQEHHFKHESSADDTECSDADQKMGDWTFSNELEISDTLNSSNQSSSRKRRGNLPKQSVKILKRWLYEHRFNAYPTDAEKVTLSQEASLTVLQVCNWFINARRRILPEMIRRDGYDPLHYTISRRGKKLSGVMGPDPLTMSPASEVIVGATEEIIEEEEVIEDGVPQIITSLGQQYVQTPSGLVKVEEDVDFEDHIIYRSDDSNIEYEYTQSEEEMPQTEQGEWEGIIRYANEKDDEIPEEITEEEVIASDGPLTEFFTSHPNIVQLQTTNASVPVGLQRLQVVNAKSAIKAETTGTVFSTGVKTTSTSLGTVKIGGNHLTAVPLKAIPKKLTVVTSSGKATTVTATPLSESNAKTISATLGTAGTQVVATMNNNNTNSNNNNSQNTNPHTTTAVKVKGVIRDDKDQFKCLYLLVETAVAVRQREKEQDDVHVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAT4</accession>
    <name>A0A084WAT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015626</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015626-RA">
        <property type="protein sequence ID" value="ASIC015626-PA"/>
        <property type="gene ID" value="ASIC015626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015626"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12093" checksum="3AA95B5DBF80F914" modified="2014-10-29" version="1">MDGSEDVKTRKTLPEAQGLMAAWGIPGGHGGGGKLPTGVLTSSPETPLRYAVDYEPALERDDESFHRGSGLLFAPFETWTSNKWDIIRHPPESVATVESLINSITTCHSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAX3</accession>
    <name>A0A084WAX3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Superoxide dismutase</fullName>
            <ecNumber evidence="3 9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00015611</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 9"/>
    <dbReference type="EMBL" id="ATLV01022274">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAX3"/>
    <dbReference type="STRING" id="74873.A0A084WAX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015611-RA">
        <property type="protein sequence ID" value="ASIC015611-PA"/>
        <property type="gene ID" value="ASIC015611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015611"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024352"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB47367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="24504" checksum="7C8D155C50B4A217" modified="2014-10-29" version="1">MLAIRGALFSTAKNCSAVLGCRSKHTLPDLPYDFGALEPVICREIMEVHHQKHHNAYVTNLNAAEEQLKDAVAKNDVSKIIQLGSAIKFNGGGHINHSIFWKNLSPERTDLSAELQKALNRDFQSMENFKKEMKAAAVAVQGSGWAWLGYNKKSKLLQVVACPNQDPLEATTGLVPLLGIDVWEHAYYLQYKNLRPNYVDAIFDVVNWKDVSERLAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB06</accession>
    <name>A0A084WB06_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptide transporter PTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015647</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015647-RA">
        <property type="protein sequence ID" value="ASIC015647-PA"/>
        <property type="gene ID" value="ASIC015647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015647"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="15949" checksum="4BB3FFA7F42446F0" modified="2014-10-29" version="1">MSGGRFICSLYSANYPSFVTEANPGSFVVREGEKQSGGHPGATVPAWHRAVMSRRKTRPPGGALRFSEIGSMMPRSFVCLFVCLFVRSSGCADLLPVCGAITCDYEKVDPLRSNGAASISWLPGPRQPGATDHFQTTGDEVAGLMEPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBR5</accession>
    <name>A0A084WBR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">von Willebrand factor D and EGF domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015702</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015702-RA">
        <property type="protein sequence ID" value="ASIC015702-PA"/>
        <property type="gene ID" value="ASIC015702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015702"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12586" checksum="F8FED13BD0EEFBA5" modified="2014-10-29" version="1">MRERGANRVVENFYDTSIKTDGRSCLQSGIRHVGQAGFGQDFTPPHRNVASVPGGTPKVTGQHGEGSEQEKKENKRNPHKSKLSIDRRSDFGCDGKPQHGNVTRAEVTESLTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEQ5</accession>
    <name>A0A084WEQ5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00016699</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01023244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEQ5"/>
    <dbReference type="STRING" id="74873.A0A084WEQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016699-RA">
        <property type="protein sequence ID" value="ASIC016699-PA"/>
        <property type="gene ID" value="ASIC016699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016699"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010885"/>
    <dbReference type="OMA" id="WNGNARV"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759992" description="Hexosyltransferase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="460" mass="51580" checksum="285027BFB1980A1E" modified="2014-10-29" version="1">MFERRVFGLLGFLLITVAIWQISPGDVAEYRESPVPYLSGAAPSLVVPSSQTEAQRRATHRGDNVLFESGGVRRAFGYAGEDGTAGHGRRSRDGAGEWSDQGATSSSSSSTQSIASLTVANAVGELLPKDDYHSLIDLEDFRFTINYDYCGVGTDDGGRSRSGGGSRNGAASGEDVGRKRRSRSRLSSLKRGDALRGTRTTPSTPPLVLVLIHSAPANLAKRNTIRTTWGRTDPRAKLIFLMGAVSSGALQRDIEQESLTHDDIVQGNFVDAYRNMTYKHVMALKWFTYHCPGARYLLKTDDDVFINTPVLYDVLERVAPQQNLLLCQLVTKLAVKRTHRSKWFVSWREYPAPYYPPHCPGYSILYSHDVARQLYHEAQRQPFFWIDDVHITGTVAQNVNVTITPMDDLYLDHDKKRTLLEVKPDRAAWMVFFFTNPNLPMHEIRELWEAVTAGRNQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFK6</accession>
    <name>A0A084WFK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000109-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFK6"/>
    <dbReference type="STRING" id="74873.A0A084WFK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017006-RA">
        <property type="protein sequence ID" value="ASIC017006-PA"/>
        <property type="gene ID" value="ASIC017006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017006"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003283"/>
    <dbReference type="OMA" id="MSYKNVA"/>
    <dbReference type="OrthoDB" id="5966508at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00928">
        <property type="entry name" value="Cyt_c_Oxidase_VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.91.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7A1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003177">
        <property type="entry name" value="Cytc_oxidase_su7a_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9759" checksum="53D2947B4568FA4D" modified="2014-10-29" version="1">MSYKNVARLVLQNSRQFSRTAPASSGEVAAGYKQLKHIQEKFQKPDGKPVFLKGGPMDNVLFGVTIALSLVGLAGIGKLFYELSYPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFW2</accession>
    <name>A0A084WFW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009646-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00017258</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFW2"/>
    <dbReference type="STRING" id="74873.A0A084WFW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017258-RA">
        <property type="protein sequence ID" value="ASIC017258-PA"/>
        <property type="gene ID" value="ASIC017258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017258"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006793"/>
    <dbReference type="OMA" id="HEEPGSI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000574">
        <property type="entry name" value="Homeobox protein CHOX-CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF9">
        <property type="entry name" value="HOMEOTIC PROTEIN CAUDAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB49106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017258-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="308" mass="33861" checksum="65985C406C81F0B1" modified="2014-10-29" version="1">METGGTRSSLDVFAKVSTITWVKPKRDDDRNAHSTHHLVPRENVYPPHSACRLVDTSAKTPTRCLPPDNTGPSQGGSMVPSLADNAARSRVNSAPREIPNLGAPSRSLARSRLSGLRKQKKPAPPGQTRAPTGFRKTRTKDKYRVVYTDQQRLELEKEFHYTRYITIRRKSELAQNLQLSERQVKIWFQNRRAKDRKQKKKAETGTVGGGQSLVGHSQGHNVHGAQSMSSLLGDTKPKLEPSLHLSHLHQMSAMSMGMGSMGLHHHHPGHHPALHPHLGVPTSQHQLNQAAAAAAAASQVPPTSLSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGF8</accession>
    <name>A0A084WGF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017417</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017417-RA">
        <property type="protein sequence ID" value="ASIC017417-PA"/>
        <property type="gene ID" value="ASIC017417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017417"/>
    <dbReference type="OrthoDB" id="545063at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="432" mass="43767" checksum="75966B2A963482DC" modified="2014-10-29" version="1">MCIKEKTLDGKEVFINVLSWTRIANPDNPDAPIPLYGGMKVGKMPPGSPKVPPLVYAVMASPEVLKKAGRKCPDTPERMNLVDLMCEFVEAMNPSLHLSKKPEILKDRDLSGELKDVWSAVQACRDKGRSDNGPPENLVVYTEFGPDTYSQEVQSAINSQVPEARDAIEQRSPAACGPTEPDGPTNGINTATSRPPAAASTGDEELAKQTESLKLSSSAHRTNGGLPADCAASTTATSSSTTTMTSSSSSSSSTVPQTQTSPTAPNANNVSTAPTDAKGVTVNGGADGTDADGGGGGAASPKTTKPAGKKSGLYFFRRNKSSTSSSSSDSKKETPSTPTKQPSAASVTLPAALTSAASAPATPAATGAACTGSSEPKLIYQYSDHQYHLDAGTNGNGGAGVGGGGNGTGGTGGGGAGDIIETASSATTIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGJ4</accession>
    <name>A0A084WGJ4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00017341</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides. Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGJ4"/>
    <dbReference type="STRING" id="74873.A0A084WGJ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017341-RA">
        <property type="protein sequence ID" value="ASIC017341-PA"/>
        <property type="gene ID" value="ASIC017341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017341"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015849"/>
    <dbReference type="OMA" id="TWHTPRD"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="68"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB49338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="316" mass="36233" checksum="58BE62212032F686" modified="2014-10-29" version="1">MKIVATRTNETHFDGVLKSILKPRIVGTATHGEVKRSIIGELKSLGFTVELDEFNQKAPHFGMLKFTNIIGKLNPDADKYLALACHYDSKYFREHAFVGAVDSAVPCAVMLNLAKTTESALKLLRNNTDLSLMLLFFDGEEAFRKWSATDSLYGSRHLATKWTTAPYVSKALSKSMREIDRVQLLVLLDLIGSENPKFYNFFSNTRNYHRRLSKIESSLREKKLLLKDPKSGTMFLDQTLYNRIEDDHLPFLKRNIPVLHLIPVPFPKHWHKPEDNEANLSRTTIKNINSVLRIFMIEHLTFCNSKYGRSLQSCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHL9</accession>
    <name>A0A084WHL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018337</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018337-RA">
        <property type="protein sequence ID" value="ASIC018337-PA"/>
        <property type="gene ID" value="ASIC018337"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018337"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018337-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12274" checksum="6788576D8F156684" modified="2014-10-29" version="1">MEPRSDPLGRTRSSRRRRRADNPHTVSTHSRSRSPITAEIFGSSSPLPRPVPEDSSRTYRRRESVGGGDSTTSRDRSRSSHAARQPITDETSRSPLTAAEEAAVSEATTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHN5</accession>
    <name>A0A084WHN5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018382</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHN5"/>
    <dbReference type="STRING" id="74873.A0A084WHN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018382-RA">
        <property type="protein sequence ID" value="ASIC018382-PA"/>
        <property type="gene ID" value="ASIC018382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018382"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009293"/>
    <dbReference type="OMA" id="GHAETHT"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784970" evidence="2">
        <location>
            <begin position="21"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="230"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="442" mass="51768" checksum="3BC1EDE03C01DC77" modified="2014-10-29" version="1">MKALVCGVLLIAIFSSGITSDSERYDVDLFMSKLFFRQNSPPEIPIAKAETDSHGEKLNEIERSFKEMQLSTQEKLMEFQKNLKERDDSMTDRYQTLQDKIAELEKNRTAKEDVFQESMERSTQEKYESLESKLVELENNITARDDSLQEIERSVENLERNVKERDEKHEDKLVEIEKHAKKTENTLQEMMQNITRLEDYSKVKHEELETNLNKLQNETKNSWDLQTEFIKNHTIPSSCKDVSRKKSGQYGIYIENGEFKTVFCEHDAFDGNWVVFQYRFNGKVNFYRGWAEYRDGFGTLDGEFWLGLKYLHQLTSTRKHELMVEVKDYNGNYGYAKYDHFEVGSEAQKFVLKRGSYSGTAGDSMTYNIGMKFTTKDSDNDDSSSTQCAERHNGAWWHGYCTNANLNGPYGNLSGDKAMYWFHLKNDYRAMVYTRMMVREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHT6</accession>
    <name>A0A084WHT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Muscle lim protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00017796</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHT6"/>
    <dbReference type="STRING" id="74873.A0A084WHT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017796-RA">
        <property type="protein sequence ID" value="ASIC017796-PA"/>
        <property type="gene ID" value="ASIC017796"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017796"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016945"/>
    <dbReference type="OMA" id="ESPKCPR"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09404">
        <property type="entry name" value="LIM1_MLP84B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017796-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="490" mass="53071" checksum="8491917B041A6727" modified="2014-10-29" version="1">MPFKPAENPKCPKCGKSVYAAEERVAGGHKFHKQCFKCGMCGKMLDSTNCAEHESELYCKNCHGRKYGPKGYGFGGGAGCLSMDTGAQFQSTDGTNGHFEPKPMSKAPEGEGCPRCGGFVYMAEQMLARGRAYHKGCFKCGECKKGLDSVNCCEGPDRNIYCKVCYGKKFGPKGYGYGKGGGALQSDSTLIESEFTLKPSTADTTAIKASPGQGCPRCGGVVFAAEQVLSKGREWHRKCYKCRDCTKTLDSIIACDGPDRDVYCKTCYGKKWGPHGYGFACGSGFLQTDCMTEEQLASQKPMVSNDTTSIKAPEGQGCPRCGGMVFAAEQQLAKGTMWHKKCFNCNECHRPLDSMIACDGPDREIHCRACYGKLFGPKGFGFGHTPTLVSTDVQSAPVQTDQKPMNGPKAKDGKGCTRCGYAVYEAEKMLSKNRIWHKRCFSCFECHKSLDSTNLNDGPNGEIYCRGCYGRNYGPRGVGFGMGAGTLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIV9</accession>
    <name>A0A084WIV9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01023950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIV9"/>
    <dbReference type="STRING" id="74873.A0A084WIV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018214-RA">
        <property type="protein sequence ID" value="ASIC018214-PA"/>
        <property type="gene ID" value="ASIC018214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018214"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018180"/>
    <dbReference type="OMA" id="QCFWGAE"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000004">
        <property type="entry name" value="Peptide methionine sulfoxide reductase A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049006">
        <property type="entry name" value="MsrA_helical"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20939">
        <property type="entry name" value="MsrA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="33"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein methionine sulfoxide reductase A helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="238" mass="26963" checksum="6B8CDB4452FBFB4B" modified="2014-10-29" version="1">MVATERLNTQEKVEELEKVRHEPLHQVDIPFEKATFGMGCFWGCDSLFGATRGVLRTRVGYAGGTTDSPVYKKMGDHTEVIEIDYDPKKISYSDLLELFWNNHEYGLTTRIKRQYMSLILYHSEEQRKIAEESRAEEQIKRAPEQIITEIAAAGAFYPAENYHQKYRLQGHSDLAKGIGLTPDLLHSSHVAARLNGYLIGVGGLEQFDEEVSLLGLSKEQAQYVRDYVIDNEGGGIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKB0</accession>
    <name>A0A084WKB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018688</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018688-RA">
        <property type="protein sequence ID" value="ASIC018688-PA"/>
        <property type="gene ID" value="ASIC018688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018688"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10720" checksum="37FABD260B24E7C2" modified="2014-10-29" version="1">MHVMESGGNELSFRAALERNRPKINYYYCAVRLCTVWVAYKRMKDVFLQRAATPSSASFCTRSCSSNLSRFERIKPLASGKLAGSGFRQMAATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKD7</accession>
    <name>A0A084WKD7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Pathogenicity factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018719</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018719-RA">
        <property type="protein sequence ID" value="ASIC018719-PA"/>
        <property type="gene ID" value="ASIC018719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018719"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6093" checksum="B783E7C5FB48D0D2" modified="2014-10-29" version="1">MNVTPGGWAAKPAGSNELVKPQPPSHRNGCNSSPAGRTHYRQKCSPLDGLSVCVCQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMK4</accession>
    <name>A0A084WMK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006516-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019929</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024475">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024478">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WMK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019929-RA">
        <property type="protein sequence ID" value="ASIC019929-PA"/>
        <property type="gene ID" value="ASIC019929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019929"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003329"/>
    <dbReference type="OMA" id="YSHERPY"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00247">
        <property type="entry name" value="Endostatin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="4">
        <location>
            <begin position="609"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="3">
        <location>
            <begin position="708"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019929-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="887" mass="92095" checksum="CD623079FF6E1169" modified="2014-10-29" version="1">MLYFGNNFLSYFSLHKASGEDPFEEPPPISPPPPEYTGYRIKGDKGERGTKGESIRGPPGPPGPQGPPGPPGPPGSPGPKGGGYFDSDGSGDXXXXXXXLALLMFRTFFLGHLYDTLPNRKHAGQCSCNATLIIEELKMDSTLREYLRGPQGMPGKEGKTGSPGLTGDKGDRGDQGAAGPEGLQGSKGEPGLDGAAGVPGPPGPPGPPGLPENYDESMLGSPIQGMRGGSPGLKGEPGDKGEIGFPGEKGEHGTKGDRGDPGLTGAKGERGHQGTHGQPGPKGPPGTPGIPGLPGQTGASGPKGDKGNTGDSGPPGPPGPPGMVVHSEGKNGTQDCQCQAGPPGPPGARGPPGIDGAPGLTGETGLPGHPGLPGDKGERGLPGLKGDKGAEFIINENVAFNSSRANKGDKGDRGQRGRRGKTGPPGPIGPPGKSNMGETWPGRPGPKGDQGPKGEKGDSAAMRGLKGDKGDRGIDGRDGLPGPPGLPAASGDGGVQYIPMPGPPGPPGQPGPPGPPGLSIVGEKGEPGLDSRSPFYSDSQHGYYGRPGGRSSLDELKALRELKHHKDYEDSTLGPPGPPGPPGPAGRPLHDSDEIPNNFGANVRIVPGAVTFQNSETMKKTTATIPVGTLAYIIDEEALLVRVNKGWQYIALGTLMEISTAPPPTTTNLPPQRSNLQSSNLVNNLPQPVDGSVVSFVPTLSVHLFFSLRMAALNEPYTGDMQGIRGADFACYRQARRAGLLGTFRAFLSSRIQNLDSIVRLADRELPVVNTRGDVLFNSWSSIFGGQGGFFSQAPRIYSFSGKNVLTDMAWPQKLVWHGSSALGERAIDTYCDAWHSPSPDKVGLASSLLGNKLLDQERYSCDNRFVVLCVEAVPQDRRRKRRDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMR0</accession>
    <name>A0A084WMR0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006579-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019562</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMR0"/>
    <dbReference type="STRING" id="74873.A0A084WMR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019562-RA">
        <property type="protein sequence ID" value="ASIC019562-PA"/>
        <property type="gene ID" value="ASIC019562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019562"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006054"/>
    <dbReference type="OMA" id="YESCHNG"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="24158" checksum="DA3D6CC1EFA583DC" modified="2014-10-29" version="1">MQENNELDSPSSTASTSPRGVVSSGRRTKKQTANGKQSAKEARAASEGKDKPSPNGTITSTPPVENKNVTPLPGFQQAFGSTEIGKFSEVFFNSSPSPADHSPSQHHPMHHQEDEQHQDQQSQHPTQPGLGRHRQQQQLLAMEALSVYESDVDTLSPQPWDPTRPGPRGPGESYEGASTGYNLQIGTSFHPAFYESSSYSDHAVDSPLGNYFSEMTCSEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPH0</accession>
    <name>A0A084WPH0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00020432</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025076">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPH0"/>
    <dbReference type="STRING" id="74873.A0A084WPH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020432-RA">
        <property type="protein sequence ID" value="ASIC020432-PA"/>
        <property type="gene ID" value="ASIC020432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020432"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000957"/>
    <dbReference type="OMA" id="HDHDYNP"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB52114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="34838" checksum="B9EDB1C714EFA7D6" modified="2014-10-29" version="1">MGLCKCPKRQVTTQFCFEHRVNVCENCMVVNHTKCTVQSYIQWLKDSDYDSNCTLCGSPRDSDDCVRLICYHVFHWKCLNARQQLLPPNTAPGGHTCPICSDPIFPPGNLVSPVADVLRVRLGQANWGRNELGLPLLLDEKRDHSKSFPVSSTTPIAAASGLGNDSVAAANGAAVYGGVHSGLAQMRAAGSSVPLLSGKERPDSPHSIVNLDQYVNVANSRRTNLLSREPPIGGSDRDDNKYKRRTPQEIFSRWSRRLYAPSARPIWRKNWFLVVTGLIAIVCIVYIMAEITTADRSGSDQHGFIPNRNLPHAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPK6</accession>
    <name>A0A084WPK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020476</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPK6"/>
    <dbReference type="STRING" id="74873.A0A084WPK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020476-RA">
        <property type="protein sequence ID" value="ASIC020476-PA"/>
        <property type="gene ID" value="ASIC020476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020476"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017325"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="313" mass="32846" checksum="6F9CA42425C45632" modified="2014-10-29" version="1">MAIALPCDSEMQIQLAFRADHEWCREPSRAATGGASRTASARTRDPSPARAPVMASCLASNTWPSLAPAATTKAAIQLRLDAKGRTYSSVVVASVVAAAVANPRTHDNYPPPPPPPPQVQPQPADQLDAPEPSTATSAIFEFPTACEGLPVPSAGNRKPEAIPLRALLQAPSVPCRIALSAIGNAPGSGGGQRGTSTYTPSNNNNNSNNVNNNTVHAGSSGSPCDEHRCISGQAAAKASTLRRHYYPEGAWGWLVLAVGTLQAILNHGVQLSGPLYLLPAGERFHQPAVNSCGKCRNIPNSFLSEEHSMMKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPP1</accession>
    <name>A0A084WPP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000998-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020291</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPP1"/>
    <dbReference type="STRING" id="74873.A0A084WPP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020291-RA">
        <property type="protein sequence ID" value="ASIC020291-PA"/>
        <property type="gene ID" value="ASIC020291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020291"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021655"/>
    <dbReference type="OrthoDB" id="10353185at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13461" checksum="99D18B0A36DE01B7" modified="2014-10-29" version="1">MTNSGFLFLFQPSNCLVVIKRQSYVICPFVGRPYPVPSQGIGAFAIIAICLTVAATAGATGWFLVWRNPERRRWLYSTVLCRRRSMDDYPSTVYSRVNNSEVSSLLLNATVSESDDDMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR60</accession>
    <name>A0A084WR60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP002943-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00020964</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ATLV01025932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR60"/>
    <dbReference type="STRING" id="74873.A0A084WR60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020964-RA">
        <property type="protein sequence ID" value="ASIC020964-PA"/>
        <property type="gene ID" value="ASIC020964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020964"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008170"/>
    <dbReference type="OMA" id="DEHFNDV"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="157"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020964-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="613" mass="67036" checksum="FDF745BADDB2A393" modified="2014-10-29" version="1">MSDEQQPAVAAPSPSHPTSLLHCIGGGGGGVPDCDATSTLVTAAAAAAAVAAASSTVPAAASAIAGASVALTEPASDPTITTIGPSPPASIVNGPTQPHGIPDFQQYDDSEDEGEDPYRSESISIERIRQYLSDKLGFYTADGFDDKDGSGGAPPRRVLDTVDIDGVLKHWKNGGFKKIVTMVGAGISTSAGIPDFRSPDTGLYNNLMKYNLPYPQAIFELEYLYQNPKPFFTLAKELYPGTFKPTPSHYFVRLLEQKGLLVRHYTQNIDTLERIAGISEEKIVEAHGTFYTNHCLQCKTAYSLEFVKEKIFADEVPTCPCGGVIKPDIVFFGEGLPERFHMLPHRDFAECDLLIIMGTSLTVQPFASLVEYVNDDCVRLLINRDKVGGGSFGFIRSMMFGEGLCFDLPGNRRDVAWTGNCDDGCFFLADQLGWGDELRELVETEHAKIKPLRPLPPIDVPSVLASPDADGAASVDMEPQTILVDEHHPLQEDEHFNDVVDGRGACVGNPGCPTAANGGVVPDNEPVHPMATDPHHETELHHHHVNPEESTHHQHHLSSELHLHQQHHHHQQQHDLHHHHQQQHDKMDDHHDDDDDVVVDHHQQSKVSPEDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR73</accession>
    <name>A0A084WR73_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101332410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020975</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525403">
        <property type="protein sequence ID" value="KFB52717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020975-RA">
        <property type="protein sequence ID" value="ASIC020975-PA"/>
        <property type="gene ID" value="ASIC020975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020975"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="19086" checksum="CA6E4BC0FAA8796F" modified="2014-10-29" version="1">MSLAVLTYTRRLERAYRGGRVGSHAPTREMQTRGFGCKTVPKRANVTRRKRAPKRNETVARRRGERPSRSRVAGVMMQSAKRPMHLQPFADKNYTTGGGPRWSGSICTRRGVCAPDNGLRLLGIMHGLAVDVGFGARLQHVERWFPLDECQRCTSLRVFASANQGQSKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR97</accession>
    <name>A0A084WR97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP002680-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">NFACT-R_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00021004</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525404">
        <property type="protein sequence ID" value="KFB52741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR97"/>
    <dbReference type="STRING" id="74873.A0A084WR97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021004-RA">
        <property type="protein sequence ID" value="ASIC021004-PA"/>
        <property type="gene ID" value="ASIC021004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021004"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007122"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="534"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="915" mass="104037" checksum="E608B7A05C91A98A" modified="2014-10-29" version="1">MTKTRFNTYDVVCSVTELQKLVGMRVNQIYDIDNKTYLIRLARNEEKVVLLLESGLRFHTTSFEWPKNMAPSGFTMKLRKHLKNKRLESLQQLGVDRIVDFQFGSGEAAYHIVLELYDRGNILLTDCDLRILNILRPHVEGEELRFAVREKYPRDRAKQDNGPPSMEQIKEAIQKAHPGDTLRTALNPVLEYGASVIDHVLHKHGLFGCRIGGEIPNDPALPKKVKKKQKNLAKEFSKVFDMETDLAPLMSAINDAESMLRAAQKEPSPGYIIQKKELKPVKEGEKEEYYFTNLEYQPYLYNQYQGEPYKQFDSFTTAVDEFYSSLESQKIDLKAFAQEREALKKLSNVKTDHAKRIEELTKVQLGDRKKAELITRNQDLVDKALLAIQSALASQMSWTDIQDLVKAAQANKDPVASCIRQLKLEINHISLYLADPYAFLDEGNSDEDEESSDREEDEEKLEPMVVDVDLALTAFANARRYYDQRRFAAKKEQKTIESSSKALKNAERKTIQTLKDVRTQTTISKVRKVYWFEKFYWFVSSENYLVIGGRDQQQNELIVKRYMRPTDIYVHAEIQGASSVIIKNPAGGEIPPKTLLEAGTMAISYSVAWDAKVVTSAYWVRSEQVSKTAPTGEYLTTGSFMIRGRKNFLPPCHLVLGLSFLFKLEDSSVERHRGERRVRTFDEESVASKDEVQSEISDHPVDQEIELDDESDNDGENKEMKKMEDASLPETVKKLSISEEPTSDASGSQSGAEEEPEKDSGVPQFPDTHVKVEHDTGKVSVKADPILQRLTSGADADSVVFLGDEKPYIIQPSAPRIKQISKSKQKAKDKEQKAKQKQAPAPKEEPQKPGQLKRGQRAKMRKIKEKYKDQDDEDRKLIMEILKSAGNRKPDEETKEDDDAAADKGKAGFSKRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRR9</accession>
    <name>A0A084WRR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026183">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021195-RA">
        <property type="protein sequence ID" value="ASIC021195-PA"/>
        <property type="gene ID" value="ASIC021195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021195"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020005"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10106" checksum="6F155BDA7B2B3816" modified="2014-10-29" version="1">MTAPGAPPCLGLGSTVDLGRCSRRPCGRGGSTPHGLLYPEFQHRPPPPSYQASMQEYRLRLLLLDRDRQSGRMRSTASPPPTYRSNVGSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTA9</accession>
    <name>A0A084WTA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">tRNA-i(6)A37 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021958</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021958-RA">
        <property type="protein sequence ID" value="ASIC021958-PA"/>
        <property type="gene ID" value="ASIC021958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021958"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="212" mass="23671" checksum="82046374D8C4860C" modified="2014-10-29" version="1">MSYGSQCRQSNRLREDASDIADQTTDRMFIYTIDAGLPTANRTGCNLRHLRFDRNRSLAVNQPTDRAGNYLDEISCSVGAIPKKVNSSQLMGFTTIRAVTTVSNRVFGHGTNIKPSIDFSLSSLGDASMPRPARFVSKHTCGRDRKWTLFRNVYHTPGRVPGCAVLWANLLQVTRVTSKCLHHDPLRAAARHFQCMRMENGEVQKAALARDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTI0</accession>
    <name>A0A084WTI0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00021753</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026893">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTI0"/>
    <dbReference type="STRING" id="74873.A0A084WTI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021753-RA">
        <property type="protein sequence ID" value="ASIC021753-PA"/>
        <property type="gene ID" value="ASIC021753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021753"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014455"/>
    <dbReference type="OMA" id="ISPPCQN"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB53524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="23896" checksum="C5E1CA68A5292B89" modified="2014-10-29" version="1">MELYSHIISPPCQNVLLVAKKLGVTLNIKETNVEDPVEVAALTKINPQHTIPTFVDEGHVIWESYAIAIYLVEKYGKDDALYPKDPKIRSVVNQRLFFDIGTLYKSILANIDAVLEGKQPSEELKEKLKKALDLTEKFVTERAFVAADHLTIADIFVLGSVTALGWLKYGLEAYPGIRSWVAKVTAEFPDYAEFHKELTEGTEAYLANNAAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTT3</accession>
    <name>A0A084WTT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002602-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00021868</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTT3"/>
    <dbReference type="STRING" id="74873.A0A084WTT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021868-RA">
        <property type="protein sequence ID" value="ASIC021868-PA"/>
        <property type="gene ID" value="ASIC021868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021868"/>
    <dbReference type="OMA" id="IHYMSRD"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="473" mass="56667" checksum="2706777FF4687C1D" modified="2014-10-29" version="1">MCFGSEYDVWILEEKQLRYWSWQNLPNYHTLDDGWFIFRHRRRDDFDWEWEHYIQFVQRHGIFFVLHVCLMELCRRYGRQLSTVLAIYGVIFIFFMYNVLVLAVLLLQCVSFYYGNSRKHYRRTVWLKAVFWIAFINYFKVWFFYDKLNVYLNIDNDQLLQLSLIISWNVIKCISFCLDKQRDPRPTEHYGLLDLLSYLLYFPLLLMGPAIVYSRFKTIHLSPDCNQRSNTLNRLTVLVGRLAMAFFWTMVILVGQHFLYVNLIQQDHVLLLNVNLWALYGLGFLMGQFFYVKYIVFYGVGIAFGSFDGIDMPAKPICIARVNQYSDMWKYFDRSLYEFLFKYIYTQLCTKTSPMPQKILASLATFAFIYVWHGVFLFILIWSFINWLCILLERLVNHYTPASSRWRAIIGTHVFIPSVVSNFFFFASEQVGFIYLRRTYTEGISNYLGLYAASYCFYQTGQLVKMMQTKRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU18</accession>
    <name>A0A084WU18_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022089</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026991">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU18"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022089-RA">
        <property type="protein sequence ID" value="ASIC022089-PA"/>
        <property type="gene ID" value="ASIC022089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022089"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9401" checksum="0224B89D640CCE26" modified="2014-10-29" version="1">MAFPVLERRVIILPSKRAESFPSKKLYTTLGPSRFSTGKHTQLRSHILIANGRKVPVEEPAGSSSEQGPKLISQSSSNAGAPRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBK8</accession>
    <name>A0A084VBK8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00001840</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01008177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524456">
        <property type="protein sequence ID" value="KFB35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBK8"/>
    <dbReference type="STRING" id="74873.A0A084VBK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001840-RA">
        <property type="protein sequence ID" value="ASIC001840-PA"/>
        <property type="gene ID" value="ASIC001840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001840"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009817"/>
    <dbReference type="OMA" id="NCKMALF"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="10">
        <location>
            <begin position="676"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130691" checksum="CE5E633B50689BDB" modified="2014-10-29" version="1">MDAGVKPFEGKLFIQTIDIRDENEEKYMRAYRGFEEITAGLSDKDFHDLLSALVSKEKQHEEISLALVYIILTDPIAAPKTYRDLTLLTRDGLGFVTNNLAMLVAEKYQKLTDIGRKQLLWLLRELIKNQVLNVDNLAWNILRQASGGDISPKNIALIEGLLEIFIEHRAWLEKDQFLVGTVAYTFVRLIEDHCGPQFVHLRSREVKFVIGLIRDRFNDIIPLGREFVRLLQNIGRIPEFDQLWKDMLYNPKSLCPTFAGVWQLLQTRTSRRFLRGRLTPEIERKIHFLTSNVKFGNQKRYQDWFQEKYFNTPESQSLRCDLIRFIISAIHPTNDMLCSDIIPRWAIIGWLLTSCTNGVTLANAKLALFYDWLFFDPMKDNIMNVEPGILVMYHSIKNHPLVSCTLLDFLCRIMKNFYPKWEDRIRTGIYNSLRKILEMKVIPNLVPLFESPKLDRELKAMLRENFREFCVPPNSMYPGQGLQGPPMPMDAAPMAPMMMMHYPPGVDGMGVEHAAHLSHPPHTLHPGQTDITLLNRMDPSRKAHDSGGPGGLGRGGPPGMMGMMPPGTTGLGLGLLAQGAGAARGVVGAATSTGMPGFVKTEQGDSGTAVEPKFSDDEEDTDGQKPAATTSSKLTEDVSDDDDLPLAKVRLLEKPAIAKVALPDALSAHLDEFLREKSAKSFEPVLQALGSCGKSALNQEQENYLTESVISVIKQTLPDRSYFPESKTDEILTASVNYPLFAAYRLLYQQEESCKKRVMALLVAIVSRINVAGYMLLYFLKVHGKLQCRRKESSGSGSTAFKASVYTVLCEALETPESVDECIEKDLNLLEKHNTQMFLWILPDMYREFKQTMLNNETVLRLLVGCIDATNLRDIIYSITQGKLIIFDEDGIGDILRKSLEYETFEQVCIWQLVQAHDIPLETFQELIPELESGAHAEALTAILLLLRSEKPTTELVRLLLSREETKHRGDPFVTSVLRYWCQEFEEKLSELIAALLTSKYPSNSPNKRKRPSKSAQQNTAPTSEHLLNHLEHFRRSCRHGNGTGTGLFVQNDMQRALQQAFAHSSESQRKQFSDLFALAAEDETSTTVGRRGTSSRGRKAPSNKKETAAEKAAAAAAAAHANNSKKAAEAASNYYSDDTSDEDWSKQKASKRRKTLSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBV6</accession>
    <name>A0A084VBV6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein alan shepard</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002152</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in the perception of gravity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01009556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524536">
        <property type="protein sequence ID" value="KFB35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBV6"/>
    <dbReference type="STRING" id="74873.A0A084VBV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002152-RA">
        <property type="protein sequence ID" value="ASIC002152-PA"/>
        <property type="gene ID" value="ASIC002152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014077"/>
    <dbReference type="OMA" id="QPAAIMF"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="287" mass="32499" checksum="D52A9776CEC9FF1E" modified="2014-10-29" version="1">MFQSNYANYPLQDADFSSYSRPRMYGDMPSSSTFGGGNPSTPHHHHNHHHHQQQHQQHHSQHHHHTSSSSTSSLTGMNFGTGSSGHAGTNLIVNYLPQDMTEREMYAMFSAMGPIESCRLMRDLKQTGYSYGFGFVNYMTEDAAQRAIKCLNGYPVRNKRLKVSYARPQSDDIKETNLYITNLPRTITEEQLDIIFGKYGTIVQKNILRDKLTGQPRGVAFVRFNKREEAQEAISALNNVIPQGGTQPLIVRVAEDHGRAKAALYVPSYNSIVHNNRGRVRMRNTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCB6</accession>
    <name>A0A084VCB6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00002455</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01010633">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524591">
        <property type="protein sequence ID" value="KFB35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCB6"/>
    <dbReference type="STRING" id="74873.A0A084VCB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002455-RA">
        <property type="protein sequence ID" value="ASIC002455-PA"/>
        <property type="gene ID" value="ASIC002455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002455"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004819"/>
    <dbReference type="OMA" id="PFYVWDL"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="287"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="44327" checksum="41EEF1AB5E165904" modified="2014-10-29" version="1">MFRRVVVGISGGVDSAVSAYLLKKRGFEVCGAFMKNWDLIDESGYCSGEQDWEDAQRLCRMLDIPLEQINFVKDYWLEVFGSFLKDYDAGITPNPDILCNRHIKFNRFYRHARERMNADAIATGHYARTNFGPFLEHYNDKENVRLLMAPDPIKDQTFFLSQITAETLKRTMFPIGALTKQQVKQLATEVGLESYARKKESMGICFVGKRSFQQFIGEYIETKPGPFVDVDSGRVVGTHAGLHHWTVGQKCKIGGCLQPYYVLRKHRDTNVIEVASGHDHPLLFTDMVYAEDPVWINVPRGLEEGRVVRCQFRFQHTKPLVDCSLIETIVACGDGARKRQLFVKLDKPLRAITPGQYAVFYRNEECFGSARILQPGPSVAYNSELMAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCF6</accession>
    <name>A0A084VCF6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010685">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010686">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524600">
        <property type="protein sequence ID" value="KFB35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VCF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002518-RA">
        <property type="protein sequence ID" value="ASIC002518-PA"/>
        <property type="gene ID" value="ASIC002518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002518"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002581"/>
    <dbReference type="OMA" id="NADGYFK"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8330" checksum="32C540082C2D2520" modified="2014-10-29" version="1">MVFVHGESYEWNSGNPYDGSVLASYGQILVVTINYRLGILGFLNANVDRFSKAPANYGLMDIIAALHWXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCJ8</accession>
    <name>A0A084VCJ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00002587</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01010794">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524614">
        <property type="protein sequence ID" value="KFB35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCJ8"/>
    <dbReference type="STRING" id="74873.A0A084VCJ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002587-RA">
        <property type="protein sequence ID" value="ASIC002587-PA"/>
        <property type="gene ID" value="ASIC002587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002587"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020957"/>
    <dbReference type="OMA" id="NRWWLDP"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="425" mass="48412" checksum="DA4DB0B761BC737B" modified="2014-10-29" version="1">MFGVGTSSYQIEGGWNADGKGESIWDRLSHEHPEKILDHSNGDVAADSYHLWKRDVEMVKELGVDIYRFSIAWSRIMPTGISNEVNEHGIAYYNNLIDELLRNGITPMVTLYHWDLPQRLQEMGGWTNELIVDHFVEYARVAYERYGDRVKIWTTFNEPWQTCENSYSNDAMSPGYIFPGIPAYLCAHNLLKSHAEAVHLYWDEFKPVQQGSIGITLDSSWCEPASDSLEDRQAAERSLRFNLGWFANPIFSATGDYPLEMRETIARLSAAQGFPESRLPSFTPEEIARIRGTSEYFGLNTYGSSMVKANDGPYDPAAGPSHEHDTNVIGYADPSWQQAASPWLNIVPWGMRKLLNWIREEYNNPPLWITENGVSDFGGTMDDMRIDYLNSYLDAVLDAIDDGCDVKGYIAWSLMDNYEWRAGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCK0</accession>
    <name>A0A084VCK0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006420-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002581</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524614">
        <property type="protein sequence ID" value="KFB35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCK0"/>
    <dbReference type="STRING" id="74873.A0A084VCK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002581-RA">
        <property type="protein sequence ID" value="ASIC002581-PA"/>
        <property type="gene ID" value="ASIC002581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002581"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005129"/>
    <dbReference type="OMA" id="MWFDEVQ"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002581-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="19428" checksum="0AB6284F8C24AB25" modified="2014-10-29" version="1">MPTLIWDDELARQAGHNARSCVYAHDVCRNTKLFRYVGQNLAHVSTTAILHFEKLVQLSIQGWWDEFNVTTQAQLDRFPEKQPGHPIGHFTQMISDRAWKMGCAAQTWFEGKVNSIFYMVCNYSFANYEGQPVYRRGLPASRCRTGENADYPGLCSTKEQIFSTPNAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCX0</accession>
    <name>A0A084VCX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002740</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524629">
        <property type="protein sequence ID" value="KFB35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002740-RA">
        <property type="protein sequence ID" value="ASIC002740-PA"/>
        <property type="gene ID" value="ASIC002740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002740"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9056" checksum="45D475933032AAEB" modified="2014-10-29" version="1">MAVRQIVRLGQSGVLTSLTTTMMVMMEEFDGLPLVPKHLGIMESLFGHRIATRVGGRVPPPGKEAKRWIALRNPGRLIDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDB9</accession>
    <name>A0A084VDB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00002942</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524657">
        <property type="protein sequence ID" value="KFB35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDB9"/>
    <dbReference type="STRING" id="74873.A0A084VDB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002942-RA">
        <property type="protein sequence ID" value="ASIC002942-PA"/>
        <property type="gene ID" value="ASIC002942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002942"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014871"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016403"/>
    <dbReference type="OMA" id="CKSIYDC"/>
    <dbReference type="OrthoDB" id="9028152at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.30:FF:000001">
        <property type="entry name" value="Serine protease 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 13 17" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759811" evidence="14">
        <location>
            <begin position="27"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="16">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="134"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="16">
        <location>
            <begin position="414"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="502"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="757" mass="83913" checksum="84E3AB2CA2BE5F42" modified="2014-10-29" version="1">MVRSVTRPLWAVVIVLLAVYIGGSHQQQCTTPTRLRGRCISIYECDSILNFFKDRLLTWEERDFLQRSQCTGATSGRAPYVCCPGNGASPVVAPTATVRPNTAAPASDVSQQLAGGLLPNPKKNECGTSIGIRIYGGENADIDEYPWLAMLQYENRKLERKYSCGGSLINQRYVITAAHCVIGEVERKEGKLVGVRLGEYNTNTEIDCVQEDQEQICADPPIDAGVESSLPHPQYDEASHAHDIALVRLAQTIQYTDFVKPVCLPLTDFRASTEGEVNYVTGFGRTLKGSRSVIKQKLGIKVYDHARCQEKYATKNAVITANQICAGGEFAKDSCHGDSGGPLMKLQKVWFLEGVVSYGNRCGLEDWPGIYTHVPAYMDWVRSNIRAAFRIIGPAFVVLLLLLGPEQAVHCQDNCRTPDHRDGICRPLKQCPSINEEYFESDRVLTEDEIGFLQQLKCKTKEVTICCPDGVMTSDRNLTSERGSLPDPKEWKCGLDTLSDRIIGGNATALDEFPWYALLQYRSKKGTLAFNCGGSLINSRYVLTAAHCLANKKIDDGETLVSVRLGEHNTATEKDCVDSSESMEEDCADPPQNFGIEEQIVHPGYDKNGLYQHNDIALIRLDKDAQINNYVLPVCLPPSNFIPTAPNVNITVVGFGHTGRQRHSGIKQKAMIPIFPRTECEKKWEKANIIEQQLCAGGLFGVDSCSGDSGGPLMVRRLYWIQEGIVSYGNQCALEGWPGIYTRVSSYIDWIKENIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDU8</accession>
    <name>A0A084VDU8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00003194</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011799">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524723">
        <property type="protein sequence ID" value="KFB36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDU8"/>
    <dbReference type="STRING" id="74873.A0A084VDU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003194-RA">
        <property type="protein sequence ID" value="ASIC003194-PA"/>
        <property type="gene ID" value="ASIC003194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003194"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007973"/>
    <dbReference type="OMA" id="LGIEMCQ"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759809" description="Lipase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="416" mass="46520" checksum="5198323864BE6E28" modified="2014-10-29" version="1">MVLSSRSGWAFLALASVVLTLAQASTIRDVIAYRAGDGPQPTDISKLTAEIITNDGYPVEEHQVTTADGYILTMFRIPGGPGNPPREGKNVAFVQHGLLCSSADWVILGPGKALAYLLVDAGYDVWLGNARGNTNSRRHIFHDPDARNTDFWDFSWHEIGFFDLPAMIDYALQYTGQTSLQYAGHSQGTTSFFIMTSLRPEYNQRIRSMHALAPVAFMSNLRSPFVRAFAPFVDQIDWLMRMLGVNEFLPSSDMMTLGGQMLCRDEARFQEVCANVLFLIGGFNSPQLNRTMLPTILSHTPAGASVNQLVHYAQGYNSGRFRQFDFGLTLNLIRYGSIRPPDYPLQRVTAPVALHYGDNDWLAAVVDVRQLHNSIANSIGLFRVSDPDFNHLDFTWAIDADTLLYNRVISFMNRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE70</accession>
    <name>A0A084VE70_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00003381</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VE70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003381-RA">
        <property type="protein sequence ID" value="ASIC003381-PA"/>
        <property type="gene ID" value="ASIC003381"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003381"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013881"/>
    <dbReference type="OMA" id="WHLTGFS"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="9">
        <location>
            <begin position="378"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="10">
        <location>
            <begin position="584"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="11">
        <location>
            <begin position="1180"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1290" mass="145176" checksum="BBCED7ADAECF50A9" modified="2014-10-29" version="1">MEGYTKDAVEILNLAQTAFVRKNSNTVVNFEVPPNLPVGQYKLSILGQGGFNFNEQISLVYLDKSLSGLIQLNKPVFKPGDSVNFRVVVLDAQLKPPADVKSVQVTIHDPNGNVIRKWSRGHLHVGVFEGALQLLPQPILGAYIINVTSDGNQLVSKAFQVKEYVLSLFDVEVFPAVIPLLEHEGLSLIVTAKYYTGQPVKGTAKVDLYLADEILEHSKTVNLYGQQQMEFRFNSPLEMTEEIFEARVIVTFTQKNTNQTITKDEKITIYKQQYQVELTTETPMFYQGLPFNYILRILLQDGSPAKDVTVQVIEGQASDNSDKVLEVEKTAKSNKDGIIKLTMHPKDTTDTITLSVLNGGQEIFYDQIGKQQFGNTFIKVEQISVSKSSVQLMVKCNKQLPFFMYYVISKGNIVDSGFVHSKTSSYKLQLDTVSKLMPKAKVFVATVVDKVVLHDIAEIDFDELQNNFDLKLNENRMIPSSQIKLRMTGSPGAYVALAAYDKSLLQHGEDHDLLFEDIMNTFDGFHELSENEFDVFHSIGLFARYTNDLIFPFDGTHNSGRFGSVKQKRSEEKFVSFRTNFLESWLWQNLTIGPQGNALLQETVPDSTTAWHLTGFSIDPVLGLGIIKRPIDFTTSQPFYIVDNLPYSIKRGEVVLLKFIVFNNYVSTVTANVTLYNVDNQTELIGRSVKDTSFSKTIDAFAKAGTPVSFLVKPRKLGEMLVRVQASIDQASDTIERVIRVEPESLMRQKMVSRFFSHDLYVNKTYAMEHTQERKADAGSKRIKFSLTPNLLTSVAENLENLLSVPSGCGEQNMVRFVPNIVVLDYLTAVGSKDTRLINKATQLLRQGYQNQLKYRQSDGSYGVWSHSGGSVFLTAFVGKSLQAASKYISEIDASQVKKAYDWLASKQHSSGRFDEVGQVIHKDMQGSLRNGIALTAYVLSAFLEHPETTRKHTKVIDKGIRYLTSSLQTTKDAYDLSIATYALTLHGHSTKTAFLEKLIGMSTIQKNGTEMFWNRKSGNIETTAYALLSFVQTERYIEGTQIMRWLVQQRYVTGSFPRTQDTFVGLRALTRLAEKISLLKNDYSVQLRYANINREFRISGRDLVRKVHEEYVDDITGIAASVSGIGFGLLELTYAYSVDRRNLTNHFTLELEKTLSNSGYKLDLRVCGSYIPRLSDTLSNMALVEVNFPSGYVAERNPISNASKMNPIRNIETRFGGTSVVVYYNNMGIEKNCFTVTATRRSKVALKRPAYVLVYDYYEIDLQAIKVYEVDSQSICDICEDDDCPETCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFM8</accession>
    <name>A0A084VFM8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00003931</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01012449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFM8"/>
    <dbReference type="STRING" id="74873.A0A084VFM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003931-RA">
        <property type="protein sequence ID" value="ASIC003931-PA"/>
        <property type="gene ID" value="ASIC003931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003931"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004994"/>
    <dbReference type="OMA" id="LHMASIF"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="98"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="28947" checksum="C4D2574D8798DBF1" modified="2014-10-29" version="1">MPKCDVKTRYIPATFAWTLLLSTTFLFFWYPCRQFYIHRHPWVPVCQAVITFFVIANFTLATFMDPGVIPKAPPDEDREDEFRAPLYKNAEINGITVRMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLISLSVHMLSIFSLSLVYVLQKEKDKLTEVEPIVAMILMAIVTLLAIPIFGLTGFHMVLVSRGRTTNEQVTGKFKGGYNPFSRRCWSNCCYTQCGPQFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFW7</accession>
    <name>A0A084VFW7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nef protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004033</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524803">
        <property type="protein sequence ID" value="KFB36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004033-RA">
        <property type="protein sequence ID" value="ASIC004033-PA"/>
        <property type="gene ID" value="ASIC004033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004033"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="24669" checksum="2EA1F4B1EDD73033" modified="2014-10-29" version="1">MSQQRGGFTMVGRRRKSGSASLIHIRKLTPQLFTHFHFPSLDSNQSPGTPPISSGPVFLLLYTATQRNAAASESEGWKILHPPSQHQQTVRRDDLDEQARENGCHRHVKGSEREFFPCQQGGTKRENNHRNHHLTLKRHFPSGTGVLKSRNYSPAPKEMIFQQPQPSPRTSGFREKPSPELTIMMVPKEKLGSIILLKPYAKKTETERGAFPQATANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGP8</accession>
    <name>A0A084VGP8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00004348</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524836">
        <property type="protein sequence ID" value="KFB37142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGP8"/>
    <dbReference type="STRING" id="74873.A0A084VGP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004348-RA">
        <property type="protein sequence ID" value="ASIC004348-PA"/>
        <property type="gene ID" value="ASIC004348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004348"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017378"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="106"/>
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            <begin position="7"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="26697" checksum="586540DC144408DF" modified="2014-10-29" version="1">MPILYTVVTRGQIVLARYAECVGNFAEVTELIVPKIQLEDHKLTYLHGNYLIHYICENRVIYLCITDDRFDRAKAFMFLQDVQQRFIATYGLAVATAIAYAMNSEFSRVLSARMRSYNEGGQQLDAISRVNGEIDELRDIMVKNIENITNRGERLELLVNQTETLRNSSVTFRQTSRNLARTMFWRNVRIYFLVAALVLFAIYVIVSMACKGLLWEGCIHSSAPQPTQPPSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHU1</accession>
    <name>A0A084VHU1_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00004765</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Endopterygota</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC004765"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="30082" checksum="D76B844D2B14AC45" modified="2014-10-29" version="1">MIGVSIVRIRPSPTGGSPDALESQLVSAFRAATLPDAETLDLRQPPSPLSPGLDPHGQQHHHHHHHHHQAAPPLSHADYSRKRAHRHVSDLPGFFPGGHGGDLGGPGSKKAKFSAAAAAAAAANYYDNAYLSFEKSLRGAFGTAGSEGLDGPGGLGVVGLDPYGGGGGAGGGAVGGGHHLLSPINYTLTAEAINRRIRSTLGLDDPMDSLGKGSPTEGEVCCQGGGGGQGVPSPDWLVGRRPALADTRPYTHSPIPPASAYEEHKFSPFSPAGNAPTLHDDNNNVDKKTFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI87</accession>
    <name>A0A084VI87_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB37681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084VI87"/>
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        <property type="protein sequence ID" value="ASIC004930-PA"/>
        <property type="gene ID" value="ASIC004930"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="584" mass="64420" checksum="F24CE66915F96B25" modified="2014-10-29" version="1">MFSVFKKLANKNEAPSVSIPESVGQTMSDSLKKRFSRGVQYNMKVVIKGDRNVGKSCLLERLQGKAFIEQYTPTEQIQVASIQWSFKATDDVVKVEVWDVVDRGKSKQKSTNLKLTTAGSGSGSPDADVPVLDAEFLDVYKGTHCVVMMMDITKAWTFDYVCRELPKVPGDIPVLLLGNHCDMGHHRVITPEQVHGFVETASAERRAEIVYGDSSMRNGFGLRLLHKFFGVPFLYLQKSALEASLRKNAQDLDICRLEIEEYQKSDDSDYGRFLENLISKKKAREGTSTQPTDPASLIRPTKSIILGAGHPIIVPDRNSHLAVSSTTTVNTTKLGPQQRQEQPTRSATMTTLSSELNFGKIDNVDEFCPDGGVLDKSFLEDTLDAGPGRQPPTVAANVGDSDDDDEGDRHNPLVTRFDDEELGVDPTDGPEVAAPETANPKAKEERFNPGERKFSLSSVELELERVGTTATGVKAKLGATDYGYGGWGPINTKERRSPEGGEDVVSTSSVNRSKSSGEKKSKDKEKKHKKKKSSKEKDETREKGEGKHHRSSKRKSHVDEFLKEMQSNADGTGDDQVDEAYEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI89</accession>
    <name>A0A084VI89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Para-aminobenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004932</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524853">
        <property type="protein sequence ID" value="KFB37683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004932-RA">
        <property type="protein sequence ID" value="ASIC004932-PA"/>
        <property type="gene ID" value="ASIC004932"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004932"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004932-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="18107" checksum="00384B025247206E" modified="2014-10-29" version="1">MENFGSSRRRTRSASFREVAISVKTVKLDLRKDFRTHPKRNHDLEHSTSRVKGKCLVRKGWRYWMDSSGYLAPSEDIVVPSMSELVLMILRDPCRKDDRFHLLSILNHGNSQPVCVHTYKRKGFPMCVRVCVQVYRAFGAPGLAAPDNSGQTDSPATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ94</accession>
    <name>A0A084VJ94_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00005307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524860">
        <property type="protein sequence ID" value="KFB38038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ94"/>
    <dbReference type="STRING" id="74873.A0A084VJ94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005307-RA">
        <property type="protein sequence ID" value="ASIC005307-PA"/>
        <property type="gene ID" value="ASIC005307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005307"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015058"/>
    <dbReference type="OMA" id="YEPMKEM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="302" mass="33166" checksum="84C0BC20CF4A95CE" modified="2014-10-29" version="1">MSEAKKTDSADGATRDQELDDLLDSALEDFNKPKDDAKKQTNKSDGAGSSGEKGEQHDDPPTEQLWNEEFLDVQAKMFEQHMAALFGGGEKVDSEQIALGFQRIAEAAGMAIRSDGAAAEETTPANTLDPSISQSISDALKAMSEGRENLQTPFSPEDVANMFGNIDLNAAGENNAFLPFMQSMMQSLLSADVLLPSLRDLVEKYPKWLEEKGSTVPKEERERYEKQLEMMKEVCAELEKEKPDDSAEVKRDRFQLVLEKMQSMQDLGQPPADLVGELGAGNLNLPTLDPSSFSEQNPCPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJQ9</accession>
    <name>A0A084VJQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013402-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJQ9"/>
    <dbReference type="STRING" id="74873.A0A084VJQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005516-RA">
        <property type="protein sequence ID" value="ASIC005516-PA"/>
        <property type="gene ID" value="ASIC005516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013778"/>
    <dbReference type="OMA" id="RQMHWHA"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF268">
        <property type="entry name" value="AGAP013402-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="275" mass="30440" checksum="F46D1E09B05BE715" modified="2014-10-29" version="1">MYDNFRATVFPLVADFSYEDPDRWAETDPDCGGSRQSPIDIELQSTTPAVGGGAALQLDGSARKPVSITVTNNGHTAQYTFDWSKDSERPRLTGGPLGQDPYVFEQLHFHWGAENDRGSEHTFNGLKFPLEAHFVFFKQEYGSFEQAVNQPDGLAVLGALYEVGGIKIQPGAKWARPLPKVREAGSSITLEGRELFSLDSVAGAEWDRYYSYPGSLTTPPCAESVTWLVRLTPALVAQKDLDLLRALHDSDGKPLVDNFRPVQPLNDRTVVRYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKX8</accession>
    <name>A0A084VKX8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00006002</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKX8"/>
    <dbReference type="SMR" id="A0A084VKX8"/>
    <dbReference type="STRING" id="74873.A0A084VKX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006002-RA">
        <property type="protein sequence ID" value="ASIC006002-PA"/>
        <property type="gene ID" value="ASIC006002"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006002"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001410"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB38622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006002-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20688" checksum="9E87E24DFAEA3674" modified="2014-10-29" version="1">MGNVFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIGEAREELMRMLAEDELRDAVLLIFANKQDLPNAMNAAEITDKLGLHSLRNRNWYIQATCATSGDGLYEGLDWLSNQLKNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL55</accession>
    <name>A0A084VL55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP005307-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006099</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006099-RA">
        <property type="protein sequence ID" value="ASIC006099-PA"/>
        <property type="gene ID" value="ASIC006099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006099"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="319" mass="36028" checksum="5DBC273ED9E8CBF4" modified="2014-10-29" version="1">MALARRGCSKTKQRRVAIGARMKRQKVQAVPSEFVLEHSTQWEEEHHETCGSPLNRQIERVAQRKHAECLNLEPAAKSKRRRIGSSCARLKDQKVQDVPLDFLLEPAPSTQWEEEYGLSHCVEGAGSVSHCVELEQHETCGSPLNRQIEPEPAHQECLITVPQSDKILIPVITTIGTQTSPSKSLENEVAELRADFQTFMSKSDKRMAVISAKLDRLLNLSVPRGELTQHSGFTMEPIEEVSQLIEFNSKLDGADYKESVELWLTTMIQEADCRGRLNDAVELCLHKKLLAKMTWTGVGNDKTAMREFENVHLHVSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM58</accession>
    <name>A0A084VM58_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM58"/>
    <dbReference type="STRING" id="74873.A0A084VM58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006374-RA">
        <property type="protein sequence ID" value="ASIC006374-PA"/>
        <property type="gene ID" value="ASIC006374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006374"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002304"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="30038" checksum="320A4A32B9F487A4" modified="2014-10-29" version="1">MATQFLNRIGQLGLGVAVVGGVVNSALYNVDGGHRAVIFDRFSGVKQQVSGEGTHFFVPWVQRPIIFDIRSQPRNVPVVTGSKDLQNVNITLRILFRPVPDQLPKIYTILGQDYDERVLPSITTEVLKAVVAQFDAGELITQREMVSQKVSDDLTERAAQFGVILDDISITHLTFGKEFTQAVEMKQVAQQEAEKARFLVEKAEQMKQAAIITAEGDAEAAKMLARSLKESGDGLIELRRIEAAEDIAYQMSRARGVSYLPAGQQTLLQIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMI8</accession>
    <name>A0A084VMI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Intraflagellar transport 52, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMI8"/>
    <dbReference type="STRING" id="74873.A0A084VMI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006520-RA">
        <property type="protein sequence ID" value="ASIC006520-PA"/>
        <property type="gene ID" value="ASIC006520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006520"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002720"/>
    <dbReference type="OMA" id="NWNVEQN"/>
    <dbReference type="OrthoDB" id="10259368at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="430" mass="49038" checksum="C159AF93D4559D58" modified="2014-10-29" version="1">MTSATILFNVTKNELFKLPDNYKTLHRKLKVNHRVESNKNEITPELLKTATVFVLAGPQEKFTETEFQYLKDYINDGGRLLLLLGEGGEVQFNTNVNFLLEDYGMTINNDVVVRPQYYKYFHPKEALISGGVSCESINNLLLDSSKSILTSFDFMDDKYKVEFVYPFGATMNVISPANVLLTTGPVVYPFNRPLAGYFQNQNNGKLVAIGSGHMFQDKYISNEVNTALWDNLFAMILQEEFKFKASDFNDLEINDYAVIPDTIYLAEQPKICLMDSLDYDIPADFKKLFDLSLYSINNDLLRDVISTYEKLDVQYEPLKIIKPQFEIPLPPLQLAVFQPIFSDLPAPPLELFDLDEAFSSEKVQITQLTNKCLSAAVEGQQPVDEKELGYFIQECGRILKVCQDDQKMSPKEILNTISVKIANYKKLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMV1</accession>
    <name>A0A084VMV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006648</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006648-RA">
        <property type="protein sequence ID" value="ASIC006648-PA"/>
        <property type="gene ID" value="ASIC006648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006648"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13717" checksum="13FDFC368D237A08" modified="2014-10-29" version="1">MLWLTLAAGNPPVPEGHIPAEPTPRTPRWPTQDIPKGDRPSEVRRRISVRARFDTCPVVTKQAYICDRKLSKMDYFEFRTSERPTVLGPSGSAWPECLNYSINMTADRPQGSSLVPAAGRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN11</accession>
    <name>A0A084VN11_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006777</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014670">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006777-RA">
        <property type="protein sequence ID" value="ASIC006777-PA"/>
        <property type="gene ID" value="ASIC006777"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006777"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006777-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8629" checksum="4731343CC3EE9CC0" modified="2014-10-29" version="1">MAGLCSGTGAGLRHTLPARPCRAAVHSVDRAHRERQYCIGATGAIRHIRRRLAVLTSRVAMVCASAHWPPSWTGGSKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN92</accession>
    <name>A0A084VN92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP008075-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00006926</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014730">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN92"/>
    <dbReference type="STRING" id="74873.A0A084VN92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006926-RA">
        <property type="protein sequence ID" value="ASIC006926-PA"/>
        <property type="gene ID" value="ASIC006926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006926"/>
    <dbReference type="OMA" id="KGNPTCY"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000111">
        <property type="entry name" value="AAEL017419-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB39436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="17144" checksum="A98F4695F7494644" modified="2014-10-29" version="1">MMSSNTCFKCDRPGHYARDCQNVGGGGGGGRGVGGPRDRRDFGRREKCYKCNQMGHFARDCKEDLDRCYRCNGSGHIARDCSLSPDDSCCYNCNQSGHLARNCPEKNDRDMNVSCYNCNKSGHISRNCPSGDKSCYSCGKIGHLSRDCTENKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNZ3</accession>
    <name>A0A084VNZ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00007462</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01014963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014964">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNZ3"/>
    <dbReference type="STRING" id="74873.A0A084VNZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007462-RA">
        <property type="protein sequence ID" value="ASIC007462-PA"/>
        <property type="gene ID" value="ASIC007462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007462"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021220"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="23413" checksum="63027ECA3A10A394" modified="2014-10-29" version="1">MASSPRAGGAAQRPNGATQNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTLCIDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNSDSFARAKTWVKELQRQASPNIVIALAGNKADLANSRVVDYEEAKQYADDNGLLFMETSAKTAVNVNDIFLAIAKKLPKNEGAGPQQNIRPTQNETNRQTSGCCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPU3</accession>
    <name>A0A084VPU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007375</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007375-RA">
        <property type="protein sequence ID" value="ASIC007375-PA"/>
        <property type="gene ID" value="ASIC007375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007375"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="12005" checksum="B1644E33E4F32F3E" modified="2014-10-29" version="1">MNTTCIIRREYTASGNGIPKSESMNAKGLLLPVLQLLFTPIYLKMSVRRNKLQRIVSRVEAIKVLQEVSRISGFHPKPGEGRRVANENPSKDMLRHIAPLPSVLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPX9</accession>
    <name>A0A084VPX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007481</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015070">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007481-RA">
        <property type="protein sequence ID" value="ASIC007481-PA"/>
        <property type="gene ID" value="ASIC007481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007481"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="153" mass="16646" checksum="EAEC0B08ACDB2EAA" modified="2014-10-29" version="1">MKLELNPGFGSLECSMASSRSHQHCCLRMHPLPRPPASPNHNRTSPSLSASKANVIVGSEDERDPFHTFTRALGPSVLGLLQDGNGDGSFSRFFLPPVPGEVWAHQHNKIVRVTGLWPTLTTDATFGGIRVWSAKSQLFGVCKRDESEPIGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPY8</accession>
    <name>A0A084VPY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Tyrosine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007508</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPY8"/>
    <dbReference type="STRING" id="74873.A0A084VPY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007508-RA">
        <property type="protein sequence ID" value="ASIC007508-PA"/>
        <property type="gene ID" value="ASIC007508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007508"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017883"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14201" checksum="3AC54839F53C1B6B" modified="2014-10-29" version="1">MEENRLYIDMDILNARARGDADYLEVPHSCLRIGREIGKGAFGRVFMASAVKLPGFNGPKIVAIKQLKRNCTIGMPCDCEYMKDFPEFLFVSHYEENVATISWRPLSNESWQQISSAHSVELQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQH2</accession>
    <name>A0A084VQH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000185-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQH2"/>
    <dbReference type="STRING" id="74873.A0A084VQH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007592-RA">
        <property type="protein sequence ID" value="ASIC007592-PA"/>
        <property type="gene ID" value="ASIC007592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007592"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017095"/>
    <dbReference type="OMA" id="IFSPHES"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000049">
        <property type="entry name" value="Uncharacterized protein, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="554" mass="60942" checksum="285995E1981D7498" modified="2014-10-29" version="1">MLLHELFTDAHFECVSSDGLQHSKFTVVVTVNDNQRFEGTGPSKKMAKNAAAKAALASICNISFSPLQQSKFGLITSGAGNGALGGPNSVSLNGDNSFKQNKNFELPQTFADAVGKCVSAYFPAHGTRLLSGLVLLELVIEKFNEVMKGSDVYSRRKVLAGFVMTHGYDVKTARVISLATGTKCVSGEHMSVTGSVINDSHAEIIARRGLMDFFYSQLDLLCQQQQSPESAPVSIIFNKPSNDSSLYTLKEGIYFHLYINTAPCGDARVFSPHENDSMDVDKHPNRKARGQLRTKVESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKISRWNVLGLQGSMLASVIEPIYLHSIVLGSLLHPAHMYRAICGRIENAIQGLPPPYRLNKPKLALMTSAESRNQTKPPNFSINWITNSSEVEIVNSFTGKLINNNTNTNKMSRLSKQSFYRRYAAIIARLPSVRLRQVKPTYFETKMSVNEYQQAKRELFAAFSKEDLGDWLKKPIEQDQFTLIVAKESEPPSLVSQQPQTVPTVELSTLVSNATSSVGNCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS38</accession>
    <name>A0A084VS38_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008213</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015797">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS38"/>
    <dbReference type="STRING" id="74873.A0A084VS38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008213-RA">
        <property type="protein sequence ID" value="ASIC008213-PA"/>
        <property type="gene ID" value="ASIC008213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008213"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020037"/>
    <dbReference type="OMA" id="DVLCWIS"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17729" checksum="BF2AB287500C8675" modified="2014-10-29" version="1">MENTDREELCELMDKILINSLELVEQDVQLSQDIDRLMTEGQIDLAHTRFTKGPNAVSAVQLPAEDYKPFRALRTVAITPDESTLPHMSLESHPVDAEEERIDPASWFGILRPPTLNSAKDKFTRSLESIVERANVRVTLGHYLSLFAALNKQNAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS40</accession>
    <name>A0A084VS40_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">oxaloacetate tautomerase</fullName>
            <ecNumber evidence="5">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008215</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.2" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01015797">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS40"/>
    <dbReference type="STRING" id="74873.A0A084VS40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008215-RA">
        <property type="protein sequence ID" value="ASIC008215-PA"/>
        <property type="gene ID" value="ASIC008215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008215"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001335"/>
    <dbReference type="OMA" id="WNIAETI"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000017">
        <property type="entry name" value="Acylpyruvase FAHD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="24120" checksum="3FC751C721E7E26D" modified="2014-10-29" version="1">MPSTKFFHSTRKIIGAGVNYKEILRLTNAPKPDAPVIFFKPISSLLDAEPSTFVPTIRVPRVFGGVINFEAELGVIIGQRCANVTPDQAMAFVGGYCLALDMTGMDFIINARPKGLPWCLGKGFDTSTPVSRFIAVKELPNPDDVRVWCDVNGVRKQDDSTSNLIFPIAELIAYTSRFMTLEENDLLLTGTPAGAGPVRHGDVIECGLGDGLVQMRCSVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSD5</accession>
    <name>A0A084VSD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008406</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008406-RA">
        <property type="protein sequence ID" value="ASIC008406-PA"/>
        <property type="gene ID" value="ASIC008406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008406"/>
    <dbReference type="OMA" id="QSIANRC"/>
    <dbReference type="OrthoDB" id="7741996at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="14058" checksum="6F11822E86CF058B" modified="2014-10-29" version="1">MGRRADVSNENRKKIVRSYLDRTSIGQIARDMNIHKSTVSCIVTKYLKTGSYCKERRQRNTPKKLNEKQIEAIGIWVEQDLYISLQSIANRCLNEFGVEVSKTTVDKYLKSICRNNQATAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSF7</accession>
    <name>A0A084VSF7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exosome complex component 10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008450</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015947">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525048">
        <property type="protein sequence ID" value="KFB40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSF7"/>
    <dbReference type="STRING" id="74873.A0A084VSF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008450-RA">
        <property type="protein sequence ID" value="ASIC008450-PA"/>
        <property type="gene ID" value="ASIC008450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008450"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014613"/>
    <dbReference type="OMA" id="RYQETCR"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="11">
        <location>
            <begin position="426"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="665"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="771"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008450-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="922" mass="105221" checksum="A26299CB0817E928" modified="2014-10-29" version="1">MKAVNAMPSGKSRDLYATHPTFIKIMDSQANKVLHIISDVLKMQGVTGNILQRDSEEKIEMIQEFNDNILERIHSNLDEMAGIKKKAPTVLVQAEVQVAPVPRYRLSGAWNEQQKQQNANSIKATLITGTNIARPQVNFKVPVDNSSLNCFVPKIREKPNSLKPLAILPEYDEAGNIVSYLHPYELELDRFCPTKAAYQKVTPQEPLSLEETELVFIDQESQLADLLSDLKEAKEIAIDLEHHSYRSFQGFTCLMQLSTRTKDYIVDTLKLRDELHVLNEVFTDRKKLKVLHGAFCDIDWLQRDLGLYLVNMFDTAEAARLLQFSRIGLQFLLKHYCKIDTDKALQLADWRIRPLPETFIEYARKDTHYLLYICDRLRNELLEKDKNLLATVYEKSTALCKQRYVKPIINEDTIMNIYRRSRYVFEHRQMYAFREILYWRDKIAREEDESTGYVLPQHMALDIASKLPREMQGILACCTPVPSLVRQHLHTLHQIVLKARELAPIAKTQPNVEQQADTRHKIQTMYDFNNPLVCPHDDNRHAGVTGEGTNMPTLLGDLTNVFQGSHGWLPQIDTALLKGAPNMGVFAGKVIRPINSRGQIGLNENDIGSERFAKLAALHYNEEEKTSVEEGEKTNLNYERNKFNTPFERYQETCRLRVLKEQKEAKDLEKRQTPAARQDVGQKEENDVEVTESQPAPATVIVVPDDVPEKVKPVNKRLLTQKQLKRLEDAKLRKDIAAGDKLCFNGTVVNAKQPEGGKRKSFPFEINVSTSSVDEANESERKEKSFNGKPHMEPYVDPAKPNDSSMVEADWRAKAGKRKRDKQLARNREKAAISKQGYRQNSNKPVTPFDYSQVDFSRFQGGSRPLPVQRKGKRPAPGAGLMRDGTDGGQSSKQLHPNSRLAKGIKKTEKLFNLSSSNLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT58</accession>
    <name>A0A084VT58_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008707</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525061">
        <property type="protein sequence ID" value="KFB41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008707-RA">
        <property type="protein sequence ID" value="ASIC008707-PA"/>
        <property type="gene ID" value="ASIC008707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008707"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13359" checksum="427A01CD1DF8612D" modified="2014-10-29" version="1">MFHQRGRRTAEIEPTGSCQRQFVPLSVGVLPVAWGTRANSEKFRLLTGRYVGMTAPSNQWQDWCRREIPGQSATFPQPREVAPLAVKARSVSFASRTASFGWFSGMRVASGMNPVEDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU71</accession>
    <name>A0A084VU71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003794-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009118</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016670">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525101">
        <property type="protein sequence ID" value="KFB41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A084VU71"/>
    <dbReference type="STRING" id="74873.A0A084VU71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009118-RA">
        <property type="protein sequence ID" value="ASIC009118-PA"/>
        <property type="gene ID" value="ASIC009118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009118"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021722"/>
    <dbReference type="OMA" id="NIGKHNA"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12945">
        <property type="entry name" value="NOPS_NONA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12333">
        <property type="entry name" value="RRM2_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor, proline-and glutamine-rich"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOPS"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="379"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB41515.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009118-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="582" mass="65928" checksum="E4B0399C75F79463" modified="2014-10-29" version="1">MDIAVKQEVNGSPLPQRQQPQHGGGGGGGVGPQGPMQGPGGDNKNNMNRNNRNNSKNRQSMGPNRGNRGGPGGGMGNNVGGGGPGGNGGPGPNRQGNHPGNQQHQGGEDGGPPQNQHQNRGMNRGNRGHDMDNSFGERRRGGGGEAFFINEKLRMLAGPLLDIPPIEAQEAKFSGRNRLYVGNLTNDVTEEELVEMFKPFGEIHEVFMNKEKNYAFVRVDFFSNAENAKRELDGTMRKNRVLRVRFAPNATAIRVKNLTPYVTNELLYKAFEVFGPLERAVVQVDERGKPTGEGIVEFKNKPGAMAAIRYCTEKCYFLTSSLRPVIVEPYTYQDDNDGLPEKSLNKKQNEFVKARQQGPRFAEHGSFEFEYGQRWKHMHELFKQKAEALKREMIMEEEKLEAQMEYAKYEQETEQLREQLRQREMDRDRQKAEWEMKERQVQEARQRNDLQMKTDIEEMTNRIKRSDEELHRRQKENTMFMQNQQMTMLEQQQMNDMGGMGGVGSGGGGGGGGNGNDNRRNFDMMNQSGGNGNFGNMFQEEYLSEMLRFLGTNMDQSKTGNKKQYNKNNKKQQQQNKNRQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU91</accession>
    <name>A0A084VU91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009203-RA">
        <property type="protein sequence ID" value="ASIC009203-PA"/>
        <property type="gene ID" value="ASIC009203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009203"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009203-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10067" checksum="38D424A1A4400117" modified="2014-10-29" version="1">MRSTGVQLKKALPEPKGPTCSDDDDDDGEKKAREQVDNLALPVDAPCRPVLGGRGVVVVGRRLVDGGELVWWVFGIATKRRLARPCASPKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVL4</accession>
    <name>A0A084VVL4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein white</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009585</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVL4"/>
    <dbReference type="STRING" id="74873.A0A084VVL4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009585-RA">
        <property type="protein sequence ID" value="ASIC009585-PA"/>
        <property type="gene ID" value="ASIC009585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009585"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018300"/>
    <dbReference type="OMA" id="MPRHLTY"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001225">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005284">
        <property type="entry name" value="Pigment_permease/Abcg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00955">
        <property type="entry name" value="3a01204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF129">
        <property type="entry name" value="PROTEIN WHITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0608">Pigment</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="97"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="700" mass="77701" checksum="516381BBE2C6A450" modified="2014-10-29" version="1">MTINTDDQYGDGENKSTISSSRRYSTSSYQDQSLEDDGINTTLTNDKATLIQVWKPKSYGSVKGQIPQHERLTYTWKEIDVFGEAPTDTKSREPFCSRLRHCFTSRQRRDFNPRKHLLKNVTGVARSGELLAVMGSSGAGKTTLLNALAFRSPPGVKISPIAVRALNGVPVNAEQLRARCAYVQQDDLFIPSLTTREHLVFQALLRMGRDVPASVKQHRVQEVLQELSLVKCADTIIGAPGRIKGLSGGERKRLAFASETLTDPHLLLCDEPTSGLDSFMAHSVLQVLKGMAMKGKTIILTIHQPSSELYCLFDKILLVAEGRVAFLGSPYQSAEFFSQLGIPCPPNYNPADFYVQMLAIAPAKEAECRETIKKICDSFAVSPIARDVLETASAVSGKTGSDEPYFLGPAEGVGSTGYRSSWWTQFYCILWRSWLSVLKDPMLVKVRLLQTAMVATLIGSIYFGQVLDQDGVMNINGSLFLFLTNMTFQNVFAVINVFSAELPVFLREKRSRLYRVDTYFLGKTIAELPLFIAVPFVFTSITYPMIGLKAGATHYLTTLFIVTLVANVSTSFGYLISCASSSISMALSVGPPVVIPFLIFGGFFLNSASVPSYFKYLSYLSWFRYANEALLINQWSTIVDGDIACTRANVTCPRSGEIILETFNFRVEDFTVDIICLFALIVLFRLGALFCLWLRSRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVS4</accession>
    <name>A0A084VVS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Phosphatidylinositol 4-kinase type II subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009652</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017221">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009652-RA">
        <property type="protein sequence ID" value="ASIC009652-PA"/>
        <property type="gene ID" value="ASIC009652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009652"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12291" checksum="1C9AB7B2505248B4" modified="2014-10-29" version="1">MNPALSPPSHPRQGSEKDDSHGWSAIGSLRARARTTKSETLRKHKKQQQQKMKKTGHIKRYTDRSWKGWMKQEGKGTGAAEANSLADAGSFEPEEASRPVDFSVSVSLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW79</accession>
    <name>A0A084VW79_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009899</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525170">
        <property type="protein sequence ID" value="KFB42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW79"/>
    <dbReference type="STRING" id="74873.A0A084VW79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009899-RA">
        <property type="protein sequence ID" value="ASIC009899-PA"/>
        <property type="gene ID" value="ASIC009899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009899"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003611"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="11">
        <location>
            <begin position="712"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="816"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="827"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009899-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="904" mass="101853" checksum="9C9DA151E3C3B5D9" modified="2014-10-29" version="1">MNLVEEESESKRDHINDIVLSEDVQRAIEQVLQSSDPLDQPDFNPTDYINQLFPNEQSLSNIDEVISKMEYDISLIDDNIRSVVRGQVNTGENGRVALKEAQQSLTQLFSLITDIKSRAEKTEDMVKEITRDIKQLDSAKNNLTYAITTLNHLHMLVGGVENLKQLSERRQYGEVLNPLQAIIEVNQHFQQYSEISQIQTLSAQVQQIQSELATQITDDFKNFFSPTAHSNTNRMTITQLKDACLVASVLDKLVKKNILKWFINLQLQEYIQLFHENQDIAWLDKIDKRYAWVKRHLLDFEEKYGTVFPADWEVSERITVQFCTITREELSKIMARRRQEIDVKLLLFAIQKTSNFEQLLDKRFNGTTLVEATSEEVRKERDSFSNLIGSCFKPYLDIYTDSISRDLTALVEQFAQQNQQMVVPKEINPGIIPNCADLFVFYKKCMVQCMQLSNEKPMYDLVLIFKKHLRDYASKVLEARIPKPQPPNSTSSTISSSMSLLTKDFQNLSTAAGQVIHNFLKEGETPRFSAEDTRKICYILATAEYCLETVQQLEDKLKEKIDKNYITKVDLADEKDVYHRIISNCIQLLVHDLDAACEQSLLLMTKIAWHSISNVGDQSGFVNQIITNLKQTVPVIRDNLANSRKYYTQFCHKFVNSFIPKYINTLYRLRPTSTGSSSASGSAALVASASSSSISESAGGSSAASGNILGCEQLLLDTHSLKTVLMDLPSIGSQVQRKPPASYTKVVVKGMAKAEMIIKVVMQPVHPASLYIEQYLKLLPESSVVEFHKILEMKNVRKVEQQQLVEAYKRACPAQQQQQQQQQQQQGSNSSATSASGEHVGNSSQAPESAPTATSTGNHQSQQMAAAAAAISGAGSSIMALGDSLMDKGRIKKIENLIKNRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW93</accession>
    <name>A0A084VW93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP003785-PE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009914</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW93"/>
    <dbReference type="STRING" id="74873.A0A084VW93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009914-RA">
        <property type="protein sequence ID" value="ASIC009914-PA"/>
        <property type="gene ID" value="ASIC009914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009914"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014521"/>
    <dbReference type="OMA" id="VNGMAYC"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="617" mass="67611" checksum="95CEE2F6A6AC6F29" modified="2014-10-29" version="1">MDSVLNGQCASPSVGPANQLFGLLVQTILAAQCTISPPDMWPKDYGPTALAQGLDEYDFVIVGAGSAGSVMASRLTENPKCKVLLLEAGGDPPIESELPFLFLTLQHTPYDWQFYARSRKARACRASPKGCYWPRGKMLGGSGAMNAMVYMRGNARDYDGWEARGNPGWGWKSALRYFRKSEDNRDPQIVRDGKYHGTGGYLSVVTSKGDSAGMQRMLQAAEEAGYPVLTDFNANKHIGFGPMQRTIVNETRCSPAKAFLVPAKQRPNLQVIKSVLVTKILFDHSKRAAAIQFTMSNGKMRSVKVKREVIVSAGVVNTPKLLMLSGIGQEKQLRAHNIPVVSDLPVGRKLQDHVTVPVIFKLNRNVAPNSSLPKDTFEYLVHRAGPLTEPGLTGLVGFVNSLDPHDPYPNVQYHHFYSPVRSGNVNSFLAAAEVNETVGRVPAIANAETDLIMVLSVLIKPKSWGSVKLQSSNPQDEPKIEAGYLYHQDDVRALIGAIRVQQKIMSTRAAAAFQPELLKLDLPACERFPYDSDAYWECYAREVSFSLYHAVGTAKMGPDGDPDAVVDSRLRVRGVRGLRVVDSSVMPEIVSGNTNAPTIMIAEKASDMVKEDYRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWV2</accession>
    <name>A0A084VWV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010116-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010146</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWV2"/>
    <dbReference type="STRING" id="74873.A0A084VWV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010146-RA">
        <property type="protein sequence ID" value="ASIC010146-PA"/>
        <property type="gene ID" value="ASIC010146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010146"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019506"/>
    <dbReference type="OrthoDB" id="7763220at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF46">
        <property type="entry name" value="CUTICULAR PROTEIN 30B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="15931" checksum="483CF9CE71F7D73E" modified="2014-10-29" version="1">MRTTTITMLRPTTSSRTPSMTSTTGDIKSQHETRHGDEVHGQYSLLDSDGHRRVVDYHADHHTGFNAVVRREPTGVKIAQPVHKVIAQPVHVSSYAHAPVAHATIQHHHAAPIAHHAAPIAHYAAPIAHSSSSIVHGASHLSHHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX42</accession>
    <name>A0A084VX42_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013287-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010246</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010246-RA">
        <property type="protein sequence ID" value="ASIC010246-PA"/>
        <property type="gene ID" value="ASIC010246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010246"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010246-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="511" mass="53255" checksum="9277C3D0C88BCAD7" modified="2014-10-29" version="1">MRRAVRCKFDFISYVLFGSDAAYDDTTTRDSVFMGGGGDGGGGGGLSLQHNVVSSGLMPPPVNAVGMGSLRRPTVVLVGDGGEQQFTVTSPPPDTTFKPELVESECSRSSVEDDSLDRFPGSTDNSLDGITFGQATRASQMMYQRRSVRLPSMDVTEDSCSNMSMMGLPGGGGSLSFAAHLDTVMHSVPLGTLMETNDMSGQQQQQQQGTAIPSPHSMLGCELTAISLCINMAVSGETAAAIETMMHQQQDILLPTSPSTGVAPSIHAGALIPGGAAHEAAAIAAAVQLIPAAGAQTVAENQATATAMLTHSEETKKAVQDIILNAAAEILTGAPEPSLATQKTINTLISMRSPEMLVVANCSPPALQPTHFVAVAQPLPEKMEIGAIMIGGLAVGAGGGALGVASVGQSLVSDPAQQPVQQPMDTSAPLPMSAPIIPMVVTPATVGGVEESLADESRALPPELTSMTETELMNYICPNAFDSGNLKWMELRQERFRFRAAQQQKIYSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E7</accession>
    <name>A0A084W0E7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011421</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011421-RA">
        <property type="protein sequence ID" value="ASIC011421-PA"/>
        <property type="gene ID" value="ASIC011421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011421"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011421-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="10037" checksum="3F5CB8DE7666F87B" modified="2014-10-29" version="1">MADLKNLAWKNGQRDGVALTKQSPHAVPSATGKQFHHRAEDAPVANWFRRIDCSAAEFASCIVPLQRSVGTVSHPVSCERKRKPPMRQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0I4</accession>
    <name>A0A084W0I4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein with SprT-like domain at the N terminus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00011462</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0I4"/>
    <dbReference type="STRING" id="74873.A0A084W0I4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011462-RA">
        <property type="protein sequence ID" value="ASIC011462-PA"/>
        <property type="gene ID" value="ASIC011462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011462"/>
    <dbReference type="OMA" id="RCTGICH"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SprT-like" evidence="16">
        <location>
            <begin position="81"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB43728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="439" mass="49872" checksum="8118124F738346B1" modified="2014-10-29" version="1">MSDSDDDVILQADPDSQASIDSKSSRAIPIKLENKQAFLAEPKVFRAEPNDLNSEEYFIEELQTYVDPDNTFEWKFIDVLPDIRAVFEKFDELFFQSRFKAKKISITWSDSMGNSCTNRNFNDEEGRYTIALNAPLLTLRPRIQIISTILHEMIHAFLKMEGIKEPNNGHGENFRKIMIHLNTMLHTNISFNHKLNDSSLVCRTEWYRCTGICHNYKPFHGIVRSVEGPPGLHNEWWKEHADSCGGTYYKIYEMTKKINGTISTRYAVNVKYMLPKRENIRGRCKTGLAPKESIDLTTDVPSVISTVNSEIIAVDMDEHDGTSTGTEAADKFIAGFSRSIPFTRDACEMQCPICQDRVKRKLFSSHIDGCKGFVRLVSWKKSANGNIVQNGLLELKAQPGLQPATAGQRSRYFSDPSASSSSTTSSFNRYQQAKRQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1A8</accession>
    <name>A0A084W1A8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PHD finger and CXXC domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011832</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1A8"/>
    <dbReference type="STRING" id="74873.A0A084W1A8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011832-RA">
        <property type="protein sequence ID" value="ASIC011832-PA"/>
        <property type="gene ID" value="ASIC011832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012181"/>
    <dbReference type="OMA" id="IRVGHKP"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000138">
        <property type="entry name" value="CXXC-type zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="15">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="481" mass="55062" checksum="A9DCAF0A0FD83477" modified="2014-10-29" version="1">MSEPKKRSKKSKEEIAKEFDLPERKSKIATILKQDGQAYCLCRSSDSSRFMICCDACEEWYHGDCINVSEKEAKHIKHYYCQRCKEEDPSLQTVFRLVPAPGPPPNPEEKKPPKKRKDKPPGGSSEKRCGQCDGCQAENCGSCDGCLGPTKNGRKQRCEMRVCSNSTSRKKDRAALKAVARNKKRRRSLSPELIINPALEGDRQCYGPGCIMTARPQSKYCSNECGMKLATSRIYQVLPQRIQEWSLSPAIGEEQNKKALESIRTKQTIVRATLAELDKRHAELDLLVERAKRCTLDPNALDNSDLEDEMSMYCITCGHEIHSKTAIRHMEKCFNKYESQASFGSIFKTRIDGNSMFCDFYNPASKTYCKRLRVLCPEHCKDPKVSDTDVCGCPLVRNVFQLTGEFCRAPKKFCFKHYVWEKIRRAEIDLERVRQWLKMDELVEQERQIRQAMASRAGVLGLMLHSTYNHEIMEKLCAGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2A3</accession>
    <name>A0A084W2A3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Heme biosynthesis protein HemY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012286</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2A3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012286-RA">
        <property type="protein sequence ID" value="ASIC012286-PA"/>
        <property type="gene ID" value="ASIC012286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012286"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012286-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8608" checksum="99165554913BE044" modified="2014-10-29" version="1">MVAVANNTPGPDKDIRIVSLPVFKWWEAGGKKEQSLQTPAPSRVLVETVDNLLPDIRYECRRFLSFSRRNKPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2M1</accession>
    <name>A0A084W2M1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP005911-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00012253</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019638">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W2M1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012253-RA">
        <property type="protein sequence ID" value="ASIC012253-PA"/>
        <property type="gene ID" value="ASIC012253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012253"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000386"/>
    <dbReference type="OMA" id="NGMAVAM"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="22614" checksum="8D8E4B76213B0BD8" modified="2014-10-29" version="1">MNELEALRQEAETLKNAIRDARKAACDTSLVQATNNLEPIGRIQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDNQXXXXXXXGRRHRLLGLVPARLELKPFAPAIRCTFATTRARHHGVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4F1</accession>
    <name>A0A084W4F1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dsim\GD16514-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013014</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4F1"/>
    <dbReference type="STRING" id="74873.A0A084W4F1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013014-RA">
        <property type="protein sequence ID" value="ASIC013014-PA"/>
        <property type="gene ID" value="ASIC013014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013014"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="16495" checksum="FE14AC78A8018B78" modified="2014-10-29" version="1">MPCPCPVLETRSAGPTGPSSAVERRRVPTYLSIFGATVEQFPAKVATEKNEPAASAASVGGRSSRSSPSTVDVTSPTNVPNSTVPPPRSPSEPASSPPQTVLPEVPTIMAGHTVQTATGPTTTAATPTATPVLAWSPLLFPPWNTALLPAAFYPALRSLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4X7</accession>
    <name>A0A084W4X7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013197</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4X7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013197-RA">
        <property type="protein sequence ID" value="ASIC013197-PA"/>
        <property type="gene ID" value="ASIC013197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013197"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022074"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9633" checksum="326154939767DF2A" modified="2014-10-29" version="1">MQKVNRAQPVAAILDEAMGNTFMFEPLFGQGVNTNTLEMSDLAEVSPHQCPPFAGCVESALPTRATRASAVISVSVPGWIFCRIRLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5W9</accession>
    <name>A0A084W5W9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008366-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013604</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5W9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013604-RA">
        <property type="protein sequence ID" value="ASIC013604-PA"/>
        <property type="gene ID" value="ASIC013604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013604"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001802"/>
    <dbReference type="OMA" id="CHPLEIN"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="329" mass="36899" checksum="EBD52577E76E8726" modified="2014-10-29" version="1">MKWLVSQRNDKGGXXXXXXXNDKGGFQSTQDTVVGLQALSKMATSLSGSEANISVKVKLSNDEEKSMAVDRDNVLVLQKYELPNATRELAMSATGSGCALFQLSYKYNIKDIDNSPRFTLNPEAKRGASVCSIELKISASFIPNADQTVSNMAVMEVDMPSGYVTEIDKTKFLQINKKVKKVETKRSDTTVVLYFDNMDETVVTVQIAAFQKHEITNPKPANVIIYDYYDNSKYHSGSISVHINDGKGNRIKQWGATVSVSPKFRFHYVQPFDKDVITRKVIPIDGKGSVEFDLREELRLEEEVFGELEKYGQRSYGSCRRKKRFASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W693</accession>
    <name>A0A084W693_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUMO-conjugating enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013707</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W693"/>
    <dbReference type="STRING" id="74873.A0A084W693"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013707-RA">
        <property type="protein sequence ID" value="ASIC013707-PA"/>
        <property type="gene ID" value="ASIC013707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013707"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009404"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="18042" checksum="5C52E640D30C7F70" modified="2014-10-29" version="1">MSGIAVARLGEERKAWRKDHPYGFVARPVKNTDGSLNLMTWECAIPGKKGTPWEGGSYKLRMLFKDDYPTSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAITIKQILLGIQDLLNEPNVKDPAQAEAYTIYCQNRLEYEKRVRAQARAMAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6E6</accession>
    <name>A0A084W6E6_ANOSI</name>
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        <submittedName>
            <fullName evidence="5">AGAP006838-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6E6"/>
    <dbReference type="STRING" id="74873.A0A084W6E6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013767-RA">
        <property type="protein sequence ID" value="ASIC013767-PA"/>
        <property type="gene ID" value="ASIC013767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020782"/>
    <dbReference type="OMA" id="HIEFYND"/>
    <dbReference type="OrthoDB" id="6510765at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784341" evidence="4">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15081" checksum="8E2A35386563F56A" modified="2014-10-29" version="1">MNLFVTAAIGVVVQLFALLTAGEHLVEFVSNYQQKAAIDYSFRYYIDHPPSGVSLDHWENRKGDYVHGGYGVLEPGGFVRTVHYEVEGDSGFRTVIKTTAPGSSQQYSIHSAGKKTQPPQPLWNTKPVAFVQGGHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6N3</accession>
    <name>A0A084W6N3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009293-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013837</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6N3"/>
    <dbReference type="STRING" id="74873.A0A084W6N3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013837-RA">
        <property type="protein sequence ID" value="ASIC013837-PA"/>
        <property type="gene ID" value="ASIC013837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013837"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="271" mass="28817" checksum="F71617AD7A50934D" modified="2014-10-29" version="1">MEQLAHFVTKSFDFNNSRVLDLLNMTATAGPTPTHHHHPSSHEYGGRNLGVGSDSDALSNTSSSLGGDLDDEIHSHALEVSHRRVPEHHQTSGEGRPRSVDHEPPRNVPDEDEETIDIEITDLSYSNGVSGVGSENVVQSVDVVGVPPELSHTSIAAAMAANQSLLGIEPPASFVASVSGSGSNKDVALNLVRAESDPRQAKMSNGLDGQTGQQVVRPKPASELLKQSVDLVNGHHFSNPSSVTSHPGVLADGESDTDWEGRSISLRRLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7X7</accession>
    <name>A0A084W7X7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014312</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7X7"/>
    <dbReference type="STRING" id="74873.A0A084W7X7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014312-RA">
        <property type="protein sequence ID" value="ASIC014312-PA"/>
        <property type="gene ID" value="ASIC014312"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014312"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001045"/>
    <dbReference type="OMA" id="IPETAGF"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014312-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="600" mass="64693" checksum="A30F627875D093BB" modified="2014-10-29" version="1">MVRCTENGILPEVGSMTISELIERKQRQINGDPEEDDDCREKFPSVGPILAAKLGGFCNKKLLLKRMPILHWLPTYEANYLIEDIVAGLSVGLTVIPQGIAFAVMANLEPQYGLYSAFMGCFVYCLFGSCKDLTIGPTAIMALMVQVYVGGLGVDFAVLLTFLVGCIILMLGLLNLGFLVQFISMPVTAGFTSAAAITIASGQVKSLLGLPGRSNEFIDSWLNVYRHFGETKLWDALLGISTITILVLLRSVRGKWSMVGKYLALSRNAIVVIGGAGLAYSFSASGSNPFSLTGTVTPGLPPVKLPPFSTVLNNQTVSFPEMSSKLGSSIVALPLIAILETIAIVKAFSKGKSIDATQELIALGLCNIFSSFVSSMPITGSFTRTAVNNNSGVRTPLGGVATGVLVLLSLGLLTDTFYFIPKSVLAGVMIAAMFFMVEFHAAAEIWRTKKVDIIPFVVTISACLLLGLEYGMLIGIGLNICFVLYMTSRPGIDQALFRTSCGIEAMVVKPDQSLIYSSIEYLKHKIVRMTDKTQVSVVIIDGSNVSYIDSTAAKILASTVDELVLRKCTVLLWNWNRSVRCTLYGGLEHLGNEVCKDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8N1</accession>
    <name>A0A084W8N1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009905-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8N1"/>
    <dbReference type="STRING" id="74873.A0A084W8N1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014613-RA">
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        <property type="gene ID" value="ASIC014613"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014613"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001764"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014613-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12303" checksum="6B6C2C4C289BE7AC" modified="2014-10-29" version="1">MAKHHPDLIFCRKQPGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W976</accession>
    <name>A0A084W976_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011018-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014773</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021648">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021650">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W976"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014773-RA">
        <property type="protein sequence ID" value="ASIC014773-PA"/>
        <property type="gene ID" value="ASIC014773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014773"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022972"/>
    <dbReference type="OMA" id="IPESEFM"/>
    <dbReference type="OrthoDB" id="7727171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784530" evidence="2">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="189" mass="21894" checksum="4A1005ADA1506BD3" modified="2014-10-29" version="1">MRKTTSLAFLFGAVLLLDFDKSYSLMRLSPIGIKATVKTNKLYVNASYALQQNGDPTNQTLDVEFYILRQIKSLKASFKYYLVAFNGSVQNALISRTVDVCSYMRRPSSDRLVNLVYSHVQRLGHIPSKCPIEPGQYYFRNLRTADLQFPIFLPESEFMLECVYYSSTTQNVYAEFRYYGKLTRFTYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R4</accession>
    <name>A0A084W9R4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014972</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01021858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9R4"/>
    <dbReference type="STRING" id="74873.A0A084W9R4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014972-RA">
        <property type="protein sequence ID" value="ASIC014972-PA"/>
        <property type="gene ID" value="ASIC014972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014972"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012855"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF70">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="66"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="397" mass="43369" checksum="DB076BA5240FE80A" modified="2014-10-29" version="1">MLSNVAKSIGQRSLFGNLKSLTNQRNNGYASEATFETRAFKLHNLEEGPSTSVTLSKEDALKYYGQMYTIRRMETAAGNLYKEKVIRGFCHLYSGQEACAVGMRAAMRPEDSCITAYRCHGWTFLMGVSVQAVLSELTGRSSGCARGKGGSMHMYGRNFYGGNGIVGAQVPLGVGIGFAAKYNGTKGACIALYGDGAANQGQLFEVYNMAKLWNSPCIFVCENNGYGMGTSVERASANTNYYTRGDYVPGIWVDGMDVLAVREATRFALEHTSSGKGPILMETATYRYSGHSMSDPGTSYRSRDEIAEVRQTRDPITSLREKILTTELASVEELKEIEGKIRAEVDAATKVAKTDKEISVDELTADIYSNPQNLTSVRNTLPLAELPHKRLGKAVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9U9</accession>
    <name>A0A084W9U9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00015004</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525325">
        <property type="protein sequence ID" value="KFB46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9U9"/>
    <dbReference type="STRING" id="74873.A0A084W9U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015004-RA">
        <property type="protein sequence ID" value="ASIC015004-PA"/>
        <property type="gene ID" value="ASIC015004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015004"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003237"/>
    <dbReference type="OMA" id="QYTRGIG"/>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20384">
        <property type="entry name" value="Tudor_ZGPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="16">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="448"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="526" mass="59397" checksum="E4479A35C3FEFEAD" modified="2014-10-29" version="1">MSSADELNESIQQYTAQITQIDQVLQLTTDKNERLELEKLKYDLTELLHLTRETLDHAIVDGTSTETKEAADRNGGDEVEDEFAQFMKEIKELDKEESDEKEAPSSDDSPAAKQDDLDLDGLVGSKCSAPHVHSWGSKVYHNAMVCSLDTSELANATATVLFTNPTHQEMIPCSYFLEGECRFSEERCRYSHGEVVRLDELRDYREPQFERLRQKGSRALVKQQPSRLWCKGTVQSVNFETKTCKVQLEEGKQREQQEVPFEDLFPLDDDEGDGSGGDKSSTDDDSSGEEADEEAIRKAQLVEKSLFQPAPDRRLGEWEEYTRGIGSKIMQKMGYVVGTGLGKEGEGRVVPVSAQVLPQGRSLDYCMELREQANGDKDLFSVEKKLIQLKKQQERKDARDYARRSAAASERKDVFSFINEQVFNGGESSSSSRANQPQGKGDLKQHSSKNLNIASLKLSEEIRRAEAEVERLKIALTRHKAGTPASDNLLKQIEAKRAEISRMQATEHNISVEQRLRNDKRKMTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Z5</accession>
    <name>A0A084W9Z5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015057</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Z5"/>
    <dbReference type="STRING" id="74873.A0A084W9Z5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015057-RA">
        <property type="protein sequence ID" value="ASIC015057-PA"/>
        <property type="gene ID" value="ASIC015057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015057"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010726"/>
    <dbReference type="OMA" id="KNSTMDF"/>
    <dbReference type="OrthoDB" id="7744434at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="30514" checksum="94D7F9ECE192787F" modified="2014-10-29" version="1">MFALWYFSLAMDELRKRFPFLDRIFAFFTGNKRSIQATGLETTHEEKPETSKEPKESAPPSEKPTPVKPAPVEPPKPVELPKPKPAPVVEPAKPVAPKVDPPKTPTTISPAVPEKTAPLTPAVATAKPASEPAPPVKPTPVEPAKPAPKPTPPVEAPKPEPAQTPAPPAQAPVKEPATVPAPTPAPTPSPAPPRLVKEKKELPTPTPKIDPVPTSTPAPPPSEPAPKTETTTVLPSNNEDSFIIVEQQKPAPAKPAPTKPKVDLKNSTMDFLQGEGGGRNVSAPSSANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA50</accession>
    <name>A0A084WA50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Circadian locomoter output cycles kaput protein (Dclock) (Dpas1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00015140</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA50"/>
    <dbReference type="STRING" id="74873.A0A084WA50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015140-RA">
        <property type="protein sequence ID" value="ASIC015140-PA"/>
        <property type="gene ID" value="ASIC015140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015140"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005813"/>
    <dbReference type="OMA" id="EQLFMAK"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990513">
        <property type="term" value="C:CLOCK-BMAL transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19735">
        <property type="entry name" value="bHLH-PAS_dCLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF3">
        <property type="entry name" value="CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="292"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="708"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="834" mass="93129" checksum="FD78EBF46D56E384" modified="2014-10-29" version="1">MYDDDEEESFGGSIDIDHHHHHHHHHHHHTDDYSAMDEDPDDKDDTKRKSRNLSEKKRRDQFNLLVNELSSMVSSNSRKMDKSTVLKSTIAFLKSHNEIAVRSRVHEIQTDWKPSFLSNEEFTHLILEALDGFIIVFSSTGRVFYASESITSLLGHLPSDLLNMTVYDMVYEDDQNDLYNILLNPTTVVDPLQTGISRENQVTFSCYIKRGTVDYRTDVSYENVQFTGYFRSDVDTESLMTTSRFSGYTSDADSRLVFVGTGRLQTPQLIREMSIVDNAKSEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHFDDLEKVVACHEALMQKGEGTSCYYRFLTKGQQWIWLQTRFYITYHQWNSKPEFVVCTHRVVSYADVMKQMRNQTAGDSKFSEDADSISVHGTERKLQQSSSQSLLATSPWSSKSSRTSRIAATPCVSPTGLSNRGRNRYNTYHGPGSDSATSISTESHTSRQSLVTQHSIISATGFIETQQYLTAIPVQPVASFSEAAPGMLSPLQSTSPHGTFSAVAAHHPAVAGAGGVVLTPCQNQVQDQLQRKHEELQHLIIQQQEELRRVQEQLLMARYGLLPSIVSLPFPAAPSNGAGPSHGPPERSTPFLQHHQPAQGAAFHHHHHHYHPSASGGQTQQPPSHPVPPDQKPIIHSADSEQLNFTDTGQGKLSESGDMISYMQLTPVPIHHLQQHQQQQQHRHHHPSSQSSTSTTPASSALNQPQHQLMQMGATPGDGSETSGSNMSNSMGLLQYQMAPEQAQILFTSGMEQQQGQAQQQPPSQQQQQPTSQPSQPPSQHQGAGSSDAGSRTQGSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA70</accession>
    <name>A0A084WA70_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015162</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA70"/>
    <dbReference type="STRING" id="74873.A0A084WA70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015162-RA">
        <property type="protein sequence ID" value="ASIC015162-PA"/>
        <property type="gene ID" value="ASIC015162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015162"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004781"/>
    <dbReference type="OMA" id="PIMTNAD"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784497" evidence="6">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="301" mass="31780" checksum="0A80501E08DBA98D" modified="2014-10-29" version="1">MLMLAVVTLLALGGNSDGARFRGTIDWSQVRPIEDFPHIAARVEQLKLRAGEPSLPAPRIVGGSVATAGQIPYQAAVLSDLPNGQALCGGALLSSNYVLTAGVCVEGTSGGVVVLGALNLQNEAEAGQVRITFAAGNVRLHEEFLGVIFRNNIAVIRLSESVTFSDRIQPVRLPVATESRTFAGVLATVSGFGRTSDASTSFSDVLRYVRNPIMTNADCFDTAWGGLIDGQKLCLHYADARAPCDGDVGGPMTVVDGGSSLLVGLYSFGSVLGCETDWPAVFVRITFYRQWIVANTDVTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAB9</accession>
    <name>A0A084WAB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015094-RA">
        <property type="protein sequence ID" value="ASIC015094-PA"/>
        <property type="gene ID" value="ASIC015094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015094"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8529" checksum="F9E9A1A0DC165CAD" modified="2014-10-29" version="1">MSYLNDVAKSRPRQGNIVVEKEYLNEEHLEENVEDVSSTPTFLLQPVRCSPQPHVPRQPRRFPNGEERKIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC28</accession>
    <name>A0A084WC28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015842</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022549">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015842-RA">
        <property type="protein sequence ID" value="ASIC015842-PA"/>
        <property type="gene ID" value="ASIC015842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015842"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12993" checksum="8D7550F71BE2A0E2" modified="2014-10-29" version="1">MVVELIGSAISRLVSNGTVRLVIVRAAPVGPGKGAKERRKEMERSEWKTPPKHFHPLRGRMYANTAGQAGPLWCVRWQPAPSDATRWQNVCWQLIKRQQRCGQPERPPEGRTQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCD3</accession>
    <name>A0A084WCD3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00015932</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015932-RA">
        <property type="protein sequence ID" value="ASIC015932-PA"/>
        <property type="gene ID" value="ASIC015932"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015932"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005935"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015932-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="615" mass="67050" checksum="FFD18C17EA80F3F4" modified="2014-10-29" version="1">MEKPYIEIDEVKIELAEGNEGNEDPLTKENIIGTATNADILMGTPSIRQVCSWISDGTNGNMCVDEISIKEIKIEPADNVDNSWQSPNEKISKNVPDKLVESAQSLSLISGTASHNEQQTKGTQRPRCKFCFIPFFNKKILTKHEKKCQQLFEHIYAASNFEDVPKGMRYTNDEVGTSSRPDDVTSNLQSHHVKSACTAPVVKVMSTVKLEEHSSSSISTPDSDPLAGDIAPIPSPLVPLSITAPVLCNSLPMSISDPLKASLPAVVDTTLLTPSLSSNLISREPPPLVPICPPVCSPASIQLRPTVSSSPHADYEQKNVPVVISPDLSTVQMNKIANDVIKTKSRIQESLGAPTGRPILMDHSVLNDFGFDPLDTRNQLEEFDEKLDRDAAFADEMVSWLSGKNVDCDAKTCVEPTVDSNPSWHVIDKAEDSSQSKPSFFGTVMHNEQQSRRLRCNYCSLLFFSDKTLTNHQKKCQQVHEQLHPAAKMPSAENKEGGTSSHLGDVTPDLPPHQCKGACPSPVAKSIVNLEDDALPLIFKADPDPLACDETSILPPPLVPLTISSPGLSNPIPISFSDPLKSHHPHNSRLRSLNNDGPTGEIAPLCSSRKCVKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCK0</accession>
    <name>A0A084WCK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016007</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01022681">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCK0"/>
    <dbReference type="STRING" id="74873.A0A084WCK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016007-RA">
        <property type="protein sequence ID" value="ASIC016007-PA"/>
        <property type="gene ID" value="ASIC016007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016007"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000413"/>
    <dbReference type="OMA" id="FTNTEHI"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046015">
        <property type="term" value="P:regulation of transcription by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB47944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="326" mass="36695" checksum="CC821F0D86280667" modified="2014-10-29" version="1">MPIGWSVLISKQNRSNGNERSNKTKNGNTDITEANGKGSNPKNRKRKAPQAENEDNDDDTKNDGSKSSGKRERTKNHESSNLSRKDKKEKTKHADNQNGISTAQNSVEIQKKHSAAADGDLRSKLVERLKGSRFRFINEQLYKTTGEEAKKLFQEDPDSFTAYHEGYRHQIAQWSMNPLDRMIKSIKKLPKDTIVADFGCGEARLAQSIPNQTYSLDLVSHNSSVIACDMANTPLESNYVNVVVFCLSLMGTNLLDFILEANRVLKVGGLLKIAEVSSRFDNVNEFVANVKKCGFTLVNKDTKHKLFYFINFKKERTLNKKESSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCN3</accession>
    <name>A0A084WCN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP013463-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00016040</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCN3"/>
    <dbReference type="STRING" id="74873.A0A084WCN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016040-RA">
        <property type="protein sequence ID" value="ASIC016040-PA"/>
        <property type="gene ID" value="ASIC016040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016040"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013071"/>
    <dbReference type="OMA" id="DERCEID"/>
    <dbReference type="OrthoDB" id="7784786at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="12">
        <location>
            <begin position="502"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016040-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="763" mass="86727" checksum="41BAF443403A1B87" modified="2014-10-29" version="1">MGKLDCELKKQLFATYEAKNLQKFICALDDGGNPYERDGEPETEESVFEKACKEPGSSEFIKACIERRDKVKSGPPPDVNAVNQNTKKCPIHLAALSYDEGNLSELLQCKDVQVDKKFDGRTALLLLFEELGKKNQPAELRGKMFANIKLLLKNGADINEPNEANVVPLCHLLTDGEDWRKEILEYCIDNHALYLDARRNQLRKAIENQFPMLMPKVRLVDEPVFLLRKKLETCIRDCDQEQFLSEYEKFCEIPGAKLTPSKRQEMIEKTVSKKMLPATQKLMEVFLVDGKLKDPGIWVSNLLEVCCMYGYVEAVEWFLQIIPRTTKGKACINNKPLLTILVKQIAKQPKDSRCDFFSCMEKLLVDERCEIDKRDPLDCTALHHAAMERIDEAQELLLKNGAYLGSKDVFGNRTISLINPALLERHLDLCITGDKLYSTNDYKKYELKIDFRNFVPPEDDKSSELVPVVQLARSFGSSRELLRHPVITSMLLLKWHLLSWCFYTNTIVCAIFFLSFMTYLVLDVHTNTSAWIPELISWVGLGYIALREILQLVLTCKSYFKSKVNWLELFLITTCVIVLARPTMGHGYRQALSIVACGLLTVEFVLLIGTLPNFSISTHMVMLKRVATNFLKLLIPYCVILFPLGVMFHLLYQTPHANKPEQKKSTETNTFGTNVSSDSTVVDSAKDENSTSDDGSFNNFDNIGQALVKMFVMFTGEFEAANLHLHESIWRTVLFLTFLFVAFCVLYNVMNGVAVGDTGVSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEB8</accession>
    <name>A0A084WEB8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016874</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEB8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016874-RA">
        <property type="protein sequence ID" value="ASIC016874-PA"/>
        <property type="gene ID" value="ASIC016874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016874"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8286" checksum="2AEEF7EE448C0253" modified="2014-10-29" version="1">MEKLHPKDAPTADWFGPLEHMATAVAPTEHHDSRKLFGRNQADEIRSVNDPRENDSREMESTARRDSTGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEB9</accession>
    <name>A0A084WEB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005787-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016876-RA">
        <property type="protein sequence ID" value="ASIC016876-PA"/>
        <property type="gene ID" value="ASIC016876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016876"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011345"/>
    <dbReference type="OMA" id="VYEQTFH"/>
    <dbReference type="OrthoDB" id="7742823at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784615" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9253" checksum="354918864F6CB735" modified="2014-10-29" version="1">MNKIISLFALVAIVALASGKPQPKPNVLAYNVAGVPVLAAAPTVASYATFYEQTFLGNLAPASYVTYSAYDPFLATVPVPVAAPVLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEX8</accession>
    <name>A0A084WEX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016780</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016780-RA">
        <property type="protein sequence ID" value="ASIC016780-PA"/>
        <property type="gene ID" value="ASIC016780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016780"/>
    <dbReference type="OrthoDB" id="7738851at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="395" mass="42814" checksum="12C16F2A89F4B33C" modified="2014-10-29" version="1">MLPLVRRFLLLTLPKRADLQELCLKFIEAYRSGLQKAEAEPQPIRIPGKDPMTCSAAYKSMSASIDRTDRKQPSEDDGTATSGQPTLRTEMKPIIIPDSDDGDEMSASDSILSVSSSTVLVHSRQAALCPVAVSGSPETTREPDRNPSSTPTTPIPWPPFTVECLFNTPPATPQQEVIAESEEDHRGGRCLTVKKPPLPSWCRLKGTVRSIERGGKKLTNVGSVTLRRTLRRLFNGGVGVGGWWSFADILAVQVPFARNVRWRSSIINVPTIPVDGCATDTRRTASFNSHELLSDRSEVVVRDSPPSDATLLQLINCLEAGDGSLSFDSTQACVDFVIPFDNPGRTDVGHPSAMNDQASPSAFGPPVDTSPLFASGSDRFVHLVTELGPVSWPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF02</accession>
    <name>A0A084WF02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP006960-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00016807</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF02"/>
    <dbReference type="STRING" id="74873.A0A084WF02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016807-RA">
        <property type="protein sequence ID" value="ASIC016807-PA"/>
        <property type="gene ID" value="ASIC016807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016807"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011841"/>
    <dbReference type="OMA" id="WIYELAS"/>
    <dbReference type="OrthoDB" id="9943809at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="12">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="480"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB48796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="775" mass="87170" checksum="D1C453822E0BC064" modified="2014-10-29" version="1">MPSPRTRSTANRSGACCVRVLGSFRNVLLGLTGLALFGALVAAAEKRSYFGCYERDRFARPALTTENLDECIDNCESSFQRYAVLSGTRCSCTNTIVTRVVEDRECDQPCGKQPDQNCGGVNAQGVYETGIEVAGPVRNLRIEGEQRESTIAIRWDLPPEDGVLVEEFLIVAEATRTYADYRIYPARWTVHNSTTSFEMSSLNPGTDYNVTVVSISGKGHEGGRASIVGSTEIGRPDPEPEEPTILRRLESTIQIRIPRASNNNGPVNYYRVVVHYVNSELIQQIDESQLNTFQKSKENKVPYYIAAELEMKDDEESLLFTVGDGREYRSYFNPPITARTHVHISIGVVSILNHVVKVRYATTTHEQHQYPDHHHVNLKTVELERNETLITILTVACVLFGIVLTAAIVLYVYLHFKTPTANTRPFADHHELTLQGPILEVENNGFMPDIYEQRGFEAELRDIIEGLEPAKNHPRKYLSLDINRILGSGKYGDVLLGSLQGPPSESVADRPAQVHVITDDMEGVDQIAFLNEFRRLTALEDHANVILFYGVCVTPDWCYLLFEQMQTTLKQTLLNARVPPNVSSAKFSTISEEIVVNILCLVCDGMQFLVDNGAVSKKLCARTVYVNTKFEVKVSAFGPPLHTEDTNQPIDIGRWHAPEVIKFQNHSAKSDVWSFGLLIWECCCLGATPFGGTTTENLFAVIRAGQKPERPPFMFEDLYQLCLNCWDLDASDRPSFDELRSYLRQTLPMLRYLLSFERKQNVQLPPYLPHLETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF44</accession>
    <name>A0A084WF44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017093</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF44"/>
    <dbReference type="STRING" id="74873.A0A084WF44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017093-RA">
        <property type="protein sequence ID" value="ASIC017093-PA"/>
        <property type="gene ID" value="ASIC017093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017093"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006353"/>
    <dbReference type="OMA" id="RDIFDCA"/>
    <dbReference type="OrthoDB" id="7492888at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF9">
        <property type="entry name" value="LUTE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="381" mass="44141" checksum="E0753A0E5EC1AA1F" modified="2014-10-29" version="1">MALANNVIPKIERVLSYDADTSTSMRKEAMVNNEFLADVVFIVGPSEKRIYAHKLLLVMSSEYFYIMFYSNFAESQTRDVVLKEDDPDVFLTIMRYIYTGEIGITFENLRELFHSAQKFMLTELTTLIRDFMLEHLVPESTLRILNENQHIGFACVNETGLDLISNNPLFYFNHEDLQLIDKPTFAMILKLKQINCTEDQLHMALETWAMVGKPEEDVDELSNIIDNLKRTYDCHELRLFGQRRVDGYLPGDLQFTLDSKTPVSLYGIGMFIKSSSRVITVELKIFQEDEKVCSDSYEITNKHLDIVHVVNLFFEEVVMLPTRRYKIIMGTSTSNSFFAFHEPTAYHDNIKLRFHAARGDSIAFAHFLCKENPNHIYDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFF3</accession>
    <name>A0A084WFF3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016947</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023342">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016947-RA">
        <property type="protein sequence ID" value="ASIC016947-PA"/>
        <property type="gene ID" value="ASIC016947"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016947"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002028"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015605"/>
    <dbReference type="OMA" id="IINCPLP"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="672"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="767"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016947-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="847" mass="90920" checksum="4CB6532A76F32DFA" modified="2014-10-29" version="1">MGYVGTTGDDDQYRVPLIAKLLHALPHYNITFHRINNTFRPSNDVYLESLGILGSIPAALLIVSLFGLLLYLLTRCCDRKPRPAHSITSLKVTLSIVTVLCCAAIGLGLYGNDDLHNGLLDVLQAGRKVDGVVSSVRNQTFILENTLTMKIQQQLTELEDIFDQKTNNQTALNQLQQALLTAKGNITIAKNAANDIRRPLVGLTITDFLSKGDQWELIRWPGTVAILALLLVLCAVLLVGVARHSRCALILFSVCGLLAVTGSWLMSGLYLSTSVAVGDLCNDPADFLVHQSPHELPADILLYYTQCDISRSNPFTQRLRESQNAINNARNAMSIVSKISPVLFKNAGLGPKLGSVNADIKLCERLLTGLTALVDCRAVHSSYLVATRGLCECGLLGLVLMLIASFMAAILLTIMVWVDSHTWIYIRKRNDYAQVEEQSYVSHQLHPQSHQNMNTRTLPHHPKGPPVISGSHTIAHPGRNAKHELTQAQQAQQQLHHQQAHAQAQQAQAQAQAHMMHHHQAMMRAGGTHTLGRLPSHSSPTHLHGPNNGKYATLSGVTGPLPLPPVYGDDNPPPLPPLRNPQKALPPPTSTVAGSEASAETTAAGTDKQIYIYSTAKYGGSIKPNPNTTTFSATPASNSKPLPSIINCPLPDIPKSAPKDDIYVKRKLLSDHPNGSKFATLKPIPVPKIDPGALQNGGKQVLANGPLPTPADAQLPPPPPPPLPATTASSSGSSGGSSSGYGTVGLTTSQIQSLPLPPPPLELLQEQQTQSTNINHHHQDHQDQALRLPPPPTSEELRSSTMDNGHTQLNGGSGVVQNGDPGLPTDGGKAVAVGNNDDNSFYAVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFJ7</accession>
    <name>A0A084WFJ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP000115-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00016996</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFJ7"/>
    <dbReference type="STRING" id="74873.A0A084WFJ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016996-RA">
        <property type="protein sequence ID" value="ASIC016996-PA"/>
        <property type="gene ID" value="ASIC016996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016996"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022007"/>
    <dbReference type="OMA" id="TFVANLM"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15392">
        <property type="entry name" value="7tmA_PR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF73">
        <property type="entry name" value="RYAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="65"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB48991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="418" mass="46591" checksum="E861351A045892BB" modified="2014-10-29" version="1">MASSTAIPMVTYDDHHYYPDAELDVEEYLECEGAIGAVPEGIANAEFQVLVWGAYCSTLTASVVGNCSVIAIVATQPHMRTVTNLFLANLALGDLLMTLFCVPFTFVSLFVLQYWPFGGALCRVVNYCQAVSVLVSAYTLVALSADRYRAIMWPMSPRRRLRKPCAHLLITLVWIGACATALPIPLFSALVQPSPWHAHCGQSVCTEVWPEPAADRGYSLAIMLAQFAVPLAALIYTYGCIGWRVWARRPPLEPTPTSTWRRQRTTTTATCSSSVSSVRQFRRARKRTLAMTLAVVAAFVICWLPFNVFLLAPLDDPEWAPLPYIYFAFHWLAMSHCCYNPLIYCYMNAKFRAGFRTLLLDPFVRLYRRTVSTLLPSTNTPPPGSLSSIHTEMVQLTTLGSSSNSNSRSPNHHHHLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFR4</accession>
    <name>A0A084WFR4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase subunit gamma-1</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00017071</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WFR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017071-RA">
        <property type="protein sequence ID" value="ASIC017071-PA"/>
        <property type="gene ID" value="ASIC017071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017071"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017054"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019365"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000024">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000004">
        <property type="entry name" value="DNA polymerase subunit gamma-1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1513"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1599"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1789"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="17">
        <location>
            <begin position="804"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB49058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1831" mass="206515" checksum="A5B99CDE9FE56626" modified="2014-10-29" version="1">MRPAFRCRWFSTGVSPENDILPHSTVRRLVRASEGNESNNKPKTGRRTLPLEHQRPPDGPKLNEMNVQMLSRSLHRQIFGCGLTSSEAASAEEHPATVKSLREELLRHGLDFSRPVVLPEVNLTLPHLRGANIEEHFWSIAEEQCEPFLRAIESLPEEVRDTPTNWSRAPGWTRYDAQTGESKPVPFPDEPALVFDVEVCVRVGMAPTMATAFGTSGSWYSWTSPQLTGEATRANDGHTGLYQLSDLIPLESDSAGQDGRKSSPRDTPALRPRIVIGHNVSYDRARVREQYWLEPTPLRFLDTMSLHVCVSGVTSYQRAMLKSNKREEGGEEWLEQASLNNLADVYALYCDGATLTGKSRRNTFVEGTLEDVAADFNNLMAYCADDVRATRAVLARLWPLFRERFPHPATLAGMLEMGSAYLPVNDNWTHYLTEADLSYEDLDLEAKHLLSQRADAACALMHDDAYRRDLWLWDQDWSVQQLKLKAPPKRKQPSKIESACRTKQEEEDAECAEEEDRLASKFAHLYESASRLPARRPLLPGYPAWYRALCSKPNAASDEGSPWQPGPAAKLGTGLQIAPKLLSLCWEGYPLHYIRGHGWGFLVPYRYERDPEQEPEEPQLPLEQLVAACPVMEPAHPGASRNESTEALQQLWKHVEATISRKEYYDRRKSGKPAPSQPQLGSGVWCNVELGGCCYFFQLPHKDGAGHRVGNPLSKDFLAKFSENVLAGDGRAAERVVEIARMLSYWRNNRDRIRGQLVVWDRLGGKQPSYGAIVPQVVVCGTLTRRAMEPTWMTASNAQRERVGSELRAMVQAPAGYRIVGADVDSQELWIASVLGDADVAHDLPGNLHGATPFGWMTLSGTKATRTDMHSVTAAAVGISRDHAKVINYARIYGAGVQFAERLLKQFNPTFTEAEARSKATKMFTLTKGRKVYRMREEVREQQYPDAPLHSSPYEALRLSRACNRPVGELFHPPRWVGGTESAMFNRLEQIAGSDAPVTPFLGGRLSRALEPPGGRSADDRFLPTRINWVVQSGAVDFLHLMLVCMRWLMGADGRTRLRFCMSFHDEVRYLVPERYAHHAALAMHVTNLLTRAFCAHRVGFRDLPQSVAFFSTVEVDRVLRKEAQHDCRTPSNPHGLNAGYGIPDGESLDIHQTLARLGPRRSDMSRWEWHRPRDTGQPNTWIEQQQQSTPSLWLDERIDAIFAHVDRIDVVNGEHSPGRTDRELLRLRTVRLYSANPGGLCPAQVSPDECHPEDGLEHFRARWSANDYGGYIIFGSLEATVLLGYYACLFDPSGTYLLTVDQQLQQDDRPTLLARLRQIWSERGAFRVFVRLRDGEILTFNPFQPPQAASSIEYGALVSIAAGDPLPSVPANDFHGFPLRIEVFRSVYSNPIVDDSRQQRSSASPAPVDYRGADVTTRDVLRQALNFTAVHVPADKDLFGDRQPNGSFSGALGRLVRREVDIVFTGFFIKDYFTRDVEFTASVYSDAVCCLVRKASRIPEALLPLFIFPGDIWALLGLLGLLCALVWGLLRRAIRGLYAHRRQLLWCRRHRLAVLFNLSRSVRRATRTRQAVQLLIDTFVLLLSAPYQRFTRSGVERLFLAGLLLVSLIFVSLYQSGLSAVFVNPLYYPDVGTLQQLEASGMAIPVKYRGFIDDVFPVNYSRLMTALRARMQYLRVPESMLTRVARLGTIATVTRRSTLALDNAIYMTTRQLHLVPECPRTYNLAYVTPRRSVLGERLNRVLLRLAGGGLVDHWIEEMRYEWTLRDRPVVQRMVQSDFKVLTVLDMQFAFYVLAIGLALSTGAITLELLFYFRSRRAPRALVDAVRMFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFV8</accession>
    <name>A0A084WFV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP009645-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFV8"/>
    <dbReference type="STRING" id="74873.A0A084WFV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017253-RA">
        <property type="protein sequence ID" value="ASIC017253-PA"/>
        <property type="gene ID" value="ASIC017253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017253"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015585"/>
    <dbReference type="OMA" id="RCIKFLA"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="578" mass="65170" checksum="34EB52132EEEA18F" modified="2014-10-29" version="1">MDEFGDRIEKLYKNYEILSDAKEKIAEHEAEYKEILDAVKGSAKEKRLASQFIGKFFKHFPSLADHAIDCQLDLCEDEDTQIRRQAIKDLPLLCRDTTEHTPRIGDILAQLLITEDAAELLQVHQSLLTLAKYDAVGTLTGIFSQIVAGDETTRFRSFQFINNKLMKMEPEILTKAVEDFIIAEVKKITLDVTADEFHQCMSILNQTKLSKTLPGHVELVTIAAEQADLESDPGALASDDENVERFIQCSTEAMPYFSSQVESTQFVKFMCEKFLRPNVWNLIGATDDQHQTQLRLLKVFAEMCAFCGTLEKPSEKVEAIYDVLLEYMPLPPLDADMNETPSFQFSHAECLLYALHILGKQAVEFLTFPEDPAKLKDFRSRLQYLARGTQGYIKKLQEAVKGKTAEEMKSEENQIKATALKTTSNISTLIRDLFHSPPSFKSVVHLSWVVPKEKKVQQKAEEATKSGTKRHAPITFDSNGKSTGDSNGSKQPKPSPTGSQKMYTPPSGKYSGKLQNNYQSFTSYTPHSHLRFRFPEFVLHSSSISAKLTSHQPSKPPNPSIEQRRAAANWINPSFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH61</accession>
    <name>A0A084WH61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017562</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017562-RA">
        <property type="protein sequence ID" value="ASIC017562-PA"/>
        <property type="gene ID" value="ASIC017562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017562"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7097" checksum="F7882997D0D60F7F" modified="2014-10-29" version="1">MSTTTSSTHISRADDRRQWDLHRSTEGQAIGVFYSKLYCTGKHSRRMEGGETEYDDGDSVPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHU5</accession>
    <name>A0A084WHU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017806</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017806-RA">
        <property type="protein sequence ID" value="ASIC017806-PA"/>
        <property type="gene ID" value="ASIC017806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017806"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12149" checksum="7962F5EB5E2D1188" modified="2014-10-29" version="1">MATGRSPGEGEAQISTEPPIARQRPPVRLQACSSSLICSAPLKDPCASSGATSAGATFSSSFRIVDDEVVFSYASTYRPIDPIDRPDPRSLLTNDLNGPEEKGSAPNVRLNNLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ22</accession>
    <name>A0A084WJ22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">UPF0397 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018285</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018285-RA">
        <property type="protein sequence ID" value="ASIC018285-PA"/>
        <property type="gene ID" value="ASIC018285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018285"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="16268" checksum="3945432C28899F4E" modified="2014-10-29" version="1">MCSRVGDARGTRHTVGVSIAIALLNSLSNTGQPCCFSPNTLLETRARSRGQSADDKLTAASFAIDDGCICGRSIYRPGEKGEPNPMWRADCAREMGGGVEGHLGNAFIVTCRGFVSPHAVPFSDPNGPLTHTDTVDHGSVAVTVKGRRRLKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJG0</accession>
    <name>A0A084WJG0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009184-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018625</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJG0"/>
    <dbReference type="STRING" id="74873.A0A084WJG0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018625-RA">
        <property type="protein sequence ID" value="ASIC018625-PA"/>
        <property type="gene ID" value="ASIC018625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018625"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022501"/>
    <dbReference type="OMA" id="MMASKIV"/>
    <dbReference type="OrthoDB" id="7745384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="481" mass="55885" checksum="C50334E311444986" modified="2014-10-29" version="1">MDLVIGKLDILQDKLLDIERNQRTNENYRNSNLEAAESGNKANENDLRAKLEEMAGKLDKMEREMMASKIVYLQDKLQDIEQKLKNSESLREENVKTAEPSNFSNEENLNELVRRMTEKEAFLQSKLEEMECANKARDEKLRCLEDKLQDVEQNLKTSIRYPPSEASTKAIEDNLCNKLDDMEVCKTADEDVAQSNLHEVLLKTAEVEKSMTAKEDPLKEAVQLIKETENKLTTQLKSLDEKWEEELQKLHGQMSEVSNLQKDVNILVESNKFILYKITKHGGRHRLVLQPNQPDLVYCDHDRFGKGWIVFQHRYNGEVDFFRGWTDYREGFGNLDGEFWLGLELLHKFTSDGKYQLLVEMEDHAGKYRYAKYDQFAVQSEKDLYKLEVGCFSGTAKDSMQYHRGGRFCTKDKNLSCFGAYDPVKHHGAWWNNPSDGIIYANLNGSYHYPSDKSMAMNWHFLNSHGMAFTRMMMRKVSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJM7</accession>
    <name>A0A084WJM7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018449</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01024043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJM7"/>
    <dbReference type="STRING" id="74873.A0A084WJM7"/>
    <dbReference type="ESTHER" id="9dipt-a0a084wjm7">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC018449-RA">
        <property type="protein sequence ID" value="ASIC018449-PA"/>
        <property type="gene ID" value="ASIC018449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018449"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012523"/>
    <dbReference type="OMA" id="MPLITGC"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="39"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="587" mass="66230" checksum="2BE163E9EA367DCE" modified="2014-10-29" version="1">MVDWDNVWQFLVAVFRLGLGCVAFLVRHRLVRLWPPGECPIVTVRQGKLRGVRAHLPNGAPYSYFKGVPYATAPVGTLRFHAPVPLDRYRQPIVDCYAERSDCIQLDFFSGLVYGAESGLYLNIYTPRLPTAGDGSSDATKLPVMVFLHGGGFACGSGSSLFYNPEYFLQRDVLVVTVNYRLGPFGFLCLPEAGIEGNAGLKDQLMALRWINENITQFGGDRNCVTLFGESAGSFSAYLHMLSPNSRRYIHRVICQSGVVCSSSFMQANPVDMAFNLARHFGYNGHSQLGALETLQKVPAKLLAKYQRKALGQAADRQSDLVFVFLPVIEQTRTDDSIITEAPETILKSYDTLRLPLLEGCNDAEGILGLYIVQRKSTENIQLLPERMASKIFRHRPAQDREEVGEAIRKFYFGDRAPTDWSPEQLKHLLSDVIFMTDSAVSAEWVAKYQPNLVHFHYRFTYDGRFSLLKRLFLNGTVDGACHGDDIFYMFNPKLLPSLSPNSEEHRVRDTVVALWTSFARHGDPSVDSQSVVNTQWRPVGKIPRDSDDFNLDCLEINVHTGMVKDPCRDRATFWRNLFQRYSKGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK23</accession>
    <name>A0A084WK23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010775-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK23"/>
    <dbReference type="STRING" id="74873.A0A084WK23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018882-RA">
        <property type="protein sequence ID" value="ASIC018882-PA"/>
        <property type="gene ID" value="ASIC018882"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018882"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011749"/>
    <dbReference type="OMA" id="HAENCAE"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018882-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15628" checksum="55B183D6402BDCB0" modified="2014-10-29" version="1">MDGSVDFYQNWTMYKNGFGDVNGEHWLGLEKLHAMTRSGTHELLVVLEDFEGDSAYALYDEFKIDSEEEKYKLTLGRYSGTAGNSMGYENGMKFSTKDDMPNLKVPCATRFKGAWWFNSCYMRGVKIMGFLPPVNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK93</accession>
    <name>A0A084WK93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Carbon-monoxide dehydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018669</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018669-RA">
        <property type="protein sequence ID" value="ASIC018669-PA"/>
        <property type="gene ID" value="ASIC018669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018669"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7440" checksum="9BB9E8762F3899AA" modified="2014-10-29" version="1">MIRRCWVRKLVTVDDDRQSAKGNSCALFGASQNGPNWWMWETVGEHSGWSVLELAFPAASSKTIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKG2</accession>
    <name>A0A084WKG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00018746</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01024119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKG2"/>
    <dbReference type="STRING" id="74873.A0A084WKG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018746-RA">
        <property type="protein sequence ID" value="ASIC018746-PA"/>
        <property type="gene ID" value="ASIC018746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018746"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000998"/>
    <dbReference type="OMA" id="QPSGRIC"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05068">
        <property type="entry name" value="PTKc_Frk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="59"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB50706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="355" mass="40248" checksum="EE8C00073765A544" modified="2014-10-29" version="1">MDDIPFGVTSITNLFFDANSRSSCPICILIMSPLVIEKPVTDGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTLEEPIYIITELMKHGSLLDYLQGKGRSLKFPQLIEMAAQIAAGMAYLESQNYIHRDLAARNVLVGDNNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPQNCNTPLYEIMLECWNKDPMRRPTFETLQWKLEDFFTMDPTFHNVLSFRAAGTSVSALRSSSPLVTVPAAVNRRPVRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLL6</accession>
    <name>A0A084WLL6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00019169</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLL6"/>
    <dbReference type="STRING" id="74873.A0A084WLL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019169-RA">
        <property type="protein sequence ID" value="ASIC019169-PA"/>
        <property type="gene ID" value="ASIC019169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019169"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020819"/>
    <dbReference type="OMA" id="INTRSYF"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB51110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019169-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="404" mass="46102" checksum="BDF7E553A89B8781" modified="2014-10-29" version="1">MDEPNSQRDRARSQLYQSLKPYLFYSQLMCSAPYPVECLQGSNGIGINTRSYFKSARFLLTAVVLSNTIMCSLEAMVELIDVPMPFFTGVLYVNEVVLGMVISLMTAGRGYKEGKHYDRFVTGILMVAEALLPSEWKNIVSSVQFRMRFTCTGLTIVVMLCLICDYVHFGSLKATLFSLGAYMMPNLLVMLSFLQCCFGTVLIYKLLQNMRHRLSPKELARCDLMERVVETERHYIQLTACMELIVRSFEYLIVINTFAGINVTSLQLLEIYQHLQQTDTAEVYIMYNSFWIVMQLCILLTVLYPCHLVKRELSRLGLTMFQLSQRGDARLEAKLARFGILTLNRKDVPYTALGMLKLELSSLSSIFVALLSFLIILIQFDSSNLNKHKGTVTTMDSLYNKIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLP3</accession>
    <name>A0A084WLP3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00019432</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01024268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLP3"/>
    <dbReference type="STRING" id="74873.A0A084WLP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019432-RA">
        <property type="protein sequence ID" value="ASIC019432-PA"/>
        <property type="gene ID" value="ASIC019432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019432"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000917"/>
    <dbReference type="OMA" id="RANCKPF"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 10" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="11">
        <location>
            <begin position="362"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB51137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="490" mass="57056" checksum="AD44AE9F7572A2DD" modified="2014-10-29" version="1">MAAQIKRSLRRYGLNEYASDLVSVRRRLPDLRDPWCLEPNRLLSVLPDTSVVIVFHNEAWSVLVRSVHSVLDRTPPHLLREIILVDDGSYFPFLKTQLEEYFHQYPKVKIRRTKERLGLIRARMFGAKQASAEILTFLDAHVECTKGWIEPLLDLVARNSTTIAIPTIDRIDEIDLQFRTKVSLLQAGAFEWDLNFGWCDRSLLHKRYGHLSEPFETPAMAGGLFTINRGFFERLGWYDEGFLIYGMENIELSMKCWMCGGTLLTVPCSRVGHIQKSAHPYLLNMSLDVSLYNSIRLAEVWMDEYRQVVLDVNGVRSYREDLFGSVSERKQVRERANCKPFRYYLERAFPELKSPAIIGQFRGEVRNAALRNNSCLTVEGRAGNVPHMSQCDGREGQYWSHSYYQDINSYKRCLDYTGSHLSTAICHRKRGNQQWMYVYETGQIWSMKHNQCLAVKVNQKGSLIMEKCNITSKYQQWRVNQVEYEFLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMH6</accession>
    <name>A0A084WMH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019898</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019898-RA">
        <property type="protein sequence ID" value="ASIC019898-PA"/>
        <property type="gene ID" value="ASIC019898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019898"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6078" checksum="78CDCFC1AEF9EF01" modified="2014-10-29" version="1">MVFKGKGKARISGTNSTWSLRVRRGSGWTVWAIKKAHLQHPASRGRIRFAAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMI2</accession>
    <name>A0A084WMI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019905</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024462">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019905-RA">
        <property type="protein sequence ID" value="ASIC019905-PA"/>
        <property type="gene ID" value="ASIC019905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019905"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17664" checksum="D8EEE9941456E121" modified="2014-10-29" version="1">MADKFVEPPNPVSCQFGCSCGRTGSEKGRLSIKRGYMRVSVRERKSILASLLYNSYKSFFHIGSHFSTYFFLVRSSYETAIATNVVRSFEPTMPAFSRIGPRTASDRQNVLNLIKKVQRQQQRKPAETAPHTIPRPGAFLEAIGEMRGEREDGLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WML5</accession>
    <name>A0A084WML5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006529-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WML5"/>
    <dbReference type="STRING" id="74873.A0A084WML5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019512-RA">
        <property type="protein sequence ID" value="ASIC019512-PA"/>
        <property type="gene ID" value="ASIC019512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019512"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013543"/>
    <dbReference type="OMA" id="WYMALAD"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019512-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="320" mass="36697" checksum="11027AB90A14391D" modified="2014-10-29" version="1">MSASLLYLLVPVGVGASLYVIRKLREWKWGWVRNNAPLRGKVFIITGANTGLGFETAQALAARQATVIMGCRSMDRAGEAIRRIRQHTQEGELVPLELDLASFTSVRQFSEAIKSRFPSFDCLINNAGLAIQTPQYTKENYEVHFGVNHLGHFLLVDLLKDNIRANAARIVVVSSKMHEKARIDFDNLGKWVERGPRDRFNNLYNNSKLMNFYFARELYKQGYNVHVLCPGLCHTDFFRDYNPKWYHYVLFSPVVLLFLRSARQGAQNIIHCATDNVNTEEKNPVTGYFVTNLEQTKSKVKFDEETSERLWRESVKALNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMS2</accession>
    <name>A0A084WMS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019577</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019577-RA">
        <property type="protein sequence ID" value="ASIC019577-PA"/>
        <property type="gene ID" value="ASIC019577"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019577"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019577-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9351" checksum="0F9A9D41456EC1E2" modified="2014-10-29" version="1">MADGWSEEKFTVLWPERHQATDGRTGGLCCASERALAHIKQTLNSADTAHCSDAATTNTTSLLSAERSGSRSMNSRWENVGLYPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMX8</accession>
    <name>A0A084WMX8_ANOSI</name>
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        <submittedName>
            <fullName evidence="8">AGAP006793-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019641</name>
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    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024527">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMX8"/>
    <dbReference type="STRING" id="74873.A0A084WMX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019641-RA">
        <property type="protein sequence ID" value="ASIC019641-PA"/>
        <property type="gene ID" value="ASIC019641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019641"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014907"/>
    <dbReference type="OMA" id="HESCQCD"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="23658" checksum="2AA98CA678D90053" modified="2014-10-29" version="1">MVLVLGISLLVSLVASLPEGTPRCSSGSDPVEYLPHPTDCARYLTCVGSTPIEQRCPDGLEWNTRESTCSPPDVAKCSSPSSQKVPSHLLRTGQVRIVGKCPSELSRCPIEVNPTDDVVFMPHADCRKFYVCSPRGPIELSCPRRLYWNHEACRCDYGRPSEVDCVVDEPQAGDTSGAHIRVRREDVTTTTEFPVASGATAKGVSSVLVLIVTMLLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNN0</accession>
    <name>A0A084WNN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019979</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC019979-PA"/>
        <property type="gene ID" value="ASIC019979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019979"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8232" checksum="2CFB40FB478062AD" modified="2014-10-29" version="1">MALRTANKSTGPPRSDVSKSGKVTQSKCGSTLLQRRIAPGAHLGRILMFAPVVGEQTTPESGTVPGKPAQCECSPGDEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNW2</accession>
    <name>A0A084WNW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Tyrosine-protein kinase SRK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020067</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525359">
        <property type="protein sequence ID" value="KFB51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WNW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020067-RA">
        <property type="protein sequence ID" value="ASIC020067-PA"/>
        <property type="gene ID" value="ASIC020067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020067"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004364"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012093"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="48368" checksum="152BBA4BC6F5B932" modified="2014-10-29" version="1">MVDVKVAQTDNSFEYTAFGKIAPPVFGVAICMANNSLNYTTRGATLFLVNSYEQMELEIVSPIETVNRTNIAVFRCQANVYNFTNWFMLLQGDREHNATGYRNMYAWEASFTIEIQSGGVVTCRAQHINGELRNVTLDLSDKLNPVTKAAASSVQLAYVGSIFGGCLAVVVIVGLVWFLWSRSNRLANTLEEGEQDEEDEENDEEDDEAAHPCNLVATIPPEYSFPKDKLLFGRRIGEDLICWATQIAFGMEYLSSKNVFHGDLAARNVLLCEKGVVKIADFGLAREFNRVTYYKKTRNDRVPFKWMALESIFEHKFSIKTDVWSYGVLLWELFTLGLPPYPTFAVNDEFFQKLKEGYRLEKPEYADEDIYYTMLSCWCVNPERRPAFHELGQFFNLMLPVELQNHYLELNDQYLPMNVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRL8</accession>
    <name>A0A084WRL8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP006109-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00021135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRL8"/>
    <dbReference type="STRING" id="74873.A0A084WRL8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021135-RA">
        <property type="protein sequence ID" value="ASIC021135-PA"/>
        <property type="gene ID" value="ASIC021135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021135"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007950"/>
    <dbReference type="OMA" id="FERKMIC"/>
    <dbReference type="OrthoDB" id="10257855at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="233" mass="25974" checksum="15B136F94B5FDB5E" modified="2014-10-29" version="1">MSLILSHIRITQSSVNSNNPEVTPTKLEKISSDIDRSAVTINSNTKSSSDTSHCPNETLCTDLPNSCLQCTYIPQCRYGAEINVSCLPKTNVVCHGDILKATTTTTEVKRPMICRYCYQTERWEHNCEQKGGCNSIDSQYKTNCTVHPEILCMGNRTFMKKIPCNWTQGYRWSTTLIVSITLGGFGADRFFLGHWQEGIGKLFSFGGLGVWTLIDVLLISLHYLGPADGSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS21</accession>
    <name>A0A084WS21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021310</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021310-RA">
        <property type="protein sequence ID" value="ASIC021310-PA"/>
        <property type="gene ID" value="ASIC021310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021310"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10442" checksum="7D1A7225DF08238D" modified="2014-10-29" version="1">MHESPTCPATVPSERFVGSVVPVASGKELAAPLSAKEAALFATVSAYESARITIGCFRLLGFCAGFRGKHMSHAEGSDSDDYDGDGDFAHYEGTLLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT22</accession>
    <name>A0A084WT22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021678</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021678-RA">
        <property type="protein sequence ID" value="ASIC021678-PA"/>
        <property type="gene ID" value="ASIC021678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021678"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013061"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13156" checksum="5BC0D9080F29DDB8" modified="2014-10-29" version="1">MWGEVLYGAGHQYDTALLPALVRPVRPFCGLWPPEAPSATRPGRKRPRQERQPGRYPEAGAHYGGVAAAGLVGAGSYGSCPPPPPPGLPGTAVTTGTLMQGVLPVKTDIRFWPLGCKMSLLLGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTB5</accession>
    <name>A0A084WTB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glutamate synthase (Ferredoxin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021965</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021965-RA">
        <property type="protein sequence ID" value="ASIC021965-PA"/>
        <property type="gene ID" value="ASIC021965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021965"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19117" checksum="C1524DEA976A59E1" modified="2014-10-29" version="1">MPPHIHPNYRALSSRETRDQMGPFFRPTLPVAENCGTHRKHSPVCVRAGPPVGFGQPVPARTSVSPIPQHNMQIFILKRLIGKRAPDRMHHGRNGRCHLKAARTATTDASDVRRKLSVRFFLRVTLFSHPFYSGLVNQWAGPAGLPVGNGNRRNVRTAFDENGDAPAQLDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTZ4</accession>
    <name>A0A084WTZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009769-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTZ4"/>
    <dbReference type="STRING" id="74873.A0A084WTZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022062-RA">
        <property type="protein sequence ID" value="ASIC022062-PA"/>
        <property type="gene ID" value="ASIC022062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022062"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004616"/>
    <dbReference type="OMA" id="CLQYFPQ"/>
    <dbReference type="OrthoDB" id="6378913at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF12">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785153" evidence="1">
        <location>
            <begin position="26"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="194"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="340" mass="37134" checksum="103B51D39ECA41D1" modified="2014-10-29" version="1">MNLSGSFALLVLVIAVGLQQTPALAQYTGPTLACGGTSLVKSTTLVTPQNVAANGINCVYNIRALNLRICQLRLDFNSFSLAQPTLDPYPRCINDVLSIENLDFDLCGENTNQHVYVPFNPTTADRTLSITFRIASRNQIPTLGTPHWSVRVQQLECPNGMAPASGASLRDTPPEMAPLPLARTLHGDVGLLAPAGCLQYHTESFGTIESFNFGTGTGPYLGGLSYAICFQRKNNPLRLQTTQFEMAASADPTVANPGFDELCYSSIQLAARSEDHLHIPNAVVQRPGAPTMRASRFCHHSLMDGTVEVSFPGPFMLFFNSDQLFDPFRREIGFRMTYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUQ3</accession>
    <name>A0A084WUQ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00022194</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUQ3"/>
    <dbReference type="STRING" id="74873.A0A084WUQ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022194-RA">
        <property type="protein sequence ID" value="ASIC022194-PA"/>
        <property type="gene ID" value="ASIC022194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022194"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023654"/>
    <dbReference type="OMA" id="LFTAKVW"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB53947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="599" mass="67323" checksum="0941018C1ED74FB6" modified="2014-10-29" version="1">MYSILYETHHINGISIAIASPTTPVREKWTSNIEFTLSCIAYSVGFGNIWKFPYTALDNGGGAFLVPYLVVLFVIGRPLYYLEMAMGQFCSRGCVKIYDMAPAMRGVGIGQSIAMLVAISYYTPVLAITLRYLLLSFSSELPWSKCDQSWSRCIDSDFRGSVESSFSNASEVRRNVSAELFFTEKIMHRSSLDEGLGWPSVELVLCLLACWLILAIILIKGVRSTGKAAYFLAIFPYVIIFILLAHALSLEGSLKGILFFLTPKWETLFTAKVWMEAVTQCFFSLSICFGGIIAYSSFNNFSNNVYRDAMIISWLDTFTSIVIGCIVFGVLGNLAHVTHKDSIQTLVREGAGLTFMAYPDAIAKFEFCPQLFSILFFLMFFIVGIGSNLGAVTSVITAIRDRCPTLANWKIVLGVSLTMCSVSVVYLTPGGLDLLEVLDTYGAKYVTLTLAFFEIVTFAWIYGVDRVCRDIKFMLRRETTLFWRICWGLLAPALVAIIMVVSFIDHVSLKVPVVYNVSGWLLYAFAILQLPLWAIYAIHIQEEKGWRAKVAAAFHPTRSWGPENDAIREQYSVMEDKINEQAGLRRRRLAHMLHRKLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUR5</accession>
    <name>A0A084WUR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022207</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022207-RA">
        <property type="protein sequence ID" value="ASIC022207-PA"/>
        <property type="gene ID" value="ASIC022207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022207"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="25424" checksum="DFA7FFA411B98C5D" modified="2014-10-29" version="1">MYMKTWTQRQLATAATAAVQQLAPGCPRTRCYYSDSNKGPTFPHSTAQHTANNTAHCRLDDVVLAVFYRVWPESREDTQPSPWTSTNGMAGERERTAYRTRLAKDKRAVPSSVFIPSCSDVSGFNNLLTNQRQKHLQVKNNKLPTREWSSDSRGKRVRKGVFSGILLRLLLYTRILRTNSQVQVLVLFCLLCPMSCRSFVVWQTQALFLKKMLHTNTHTNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9W5</accession>
    <name>A0A084V9W5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000147</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523906">
        <property type="protein sequence ID" value="KFB34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9W5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000147-RA">
        <property type="protein sequence ID" value="ASIC000147-PA"/>
        <property type="gene ID" value="ASIC000147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000147"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8864" checksum="FF6719A1CD309D35" modified="2014-10-29" version="1">MESMRSGNETRYKHLTHAPATKDSRGKKKNNTTARSAARVFPSESGSAERTGSYGSSRRKSFHNTVACMSFRAGTFSTVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAT6</accession>
    <name>A0A084VAT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000971</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524214">
        <property type="protein sequence ID" value="KFB35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000971-RA">
        <property type="protein sequence ID" value="ASIC000971-PA"/>
        <property type="gene ID" value="ASIC000971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000971"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="7032" checksum="901A67DC7E3A4163" modified="2014-10-29" version="1">MCDIRREYHRMLRRVPSSREDVKIELSPYHDALRKPALSSVAGFTGCPFRQSNALVRSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB84</accession>
    <name>A0A084VB84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001354</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524335">
        <property type="protein sequence ID" value="KFB35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001354-RA">
        <property type="protein sequence ID" value="ASIC001354-PA"/>
        <property type="gene ID" value="ASIC001354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001354"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="18262" checksum="97E27F9BE53638EB" modified="2014-10-29" version="1">MAGRKNNGRWDERFRNRISCVLLNLEWSRLWSSSTRRKARGTLPGGGISRNASELARHDCSWRHSQRHSQRTAVGTPLVGRPNECLPLFRFLGLVSDRCAALHRRSYIRLTDRTGSQHLRYKNSEDNSSGDSDAQMYAKRFGRHGVGAWFTPKEECPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDD7</accession>
    <name>A0A084VDD7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="18">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00002963</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="18"/>
    <dbReference type="EMBL" id="ATLV01011268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524660">
        <property type="protein sequence ID" value="KFB35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDD7"/>
    <dbReference type="STRING" id="74873.A0A084VDD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002963-RA">
        <property type="protein sequence ID" value="ASIC002963-PA"/>
        <property type="gene ID" value="ASIC002963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002963"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009396"/>
    <dbReference type="OMA" id="PESFGWD"/>
    <dbReference type="OrthoDB" id="7737162at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000002">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002963-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="594" mass="68665" checksum="8FB342942BFC00BE" modified="2014-10-29" version="1">MFLVAMTGVTLIVRQQRYTTHPPAQLQRRYQERFLNYDDHVRFGVYGEGQEPMPEFTDLVSQKTMERYSYHSSPRQMVDTAAESANKEKNTRIPRTTFDTYQPRYQNASNWLRIDDAVPGESVGLSIDHEKRDYVRQMMIHAWSNYKLYAWGKNELRPLSKRGHSNSIFGSFDLGATIVDGLDTLYLMGLHKEFDEGRDWVERKFTLENVDADLSVFETNIRFVGGFLTCYAFTGDRLFLEKAKYVADKLLPAFQTPTGIPYALVNVRNGVSKNYGWASGGSSILSEFGTLHLEFSYLSDITGDTVYRDRVQTIRAVLKDIEKPKGLYPNYLNPKTGKWGQQHMSLGALGDSFYEYLLKAWIQSGHEDDEAREMYDEAMQAIIQHMVRRTPSGLVYVSDMKFDRLEHKMDHLACFAGGLFGLGSTTLTNQYSQRYMEIGEGLTNTCHESYIRTYTRLGPESFRFNDGVEAKALKAQEKYYILRPETFESYFIMWRLTHDQKYREWGWDAVQALEKHCRTQTGYSGLKNVYHTDPVKDDVQQSFFLAETLKYLYLLFSDDSLLPLDEWVFNTEAHPLPVKDRNSLYRPAAVSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDI8</accession>
    <name>A0A084VDI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003047</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524685">
        <property type="protein sequence ID" value="KFB36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003047-RA">
        <property type="protein sequence ID" value="ASIC003047-PA"/>
        <property type="gene ID" value="ASIC003047"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003047"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003047-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="18784" checksum="A4637836EA7822CF" modified="2014-10-29" version="1">MERTSSEQANERTGKRVAQADGPLCPIVNVSSSSTTQPRVVGSAEPARRGRGWWRDGEIVHKPRAEAYQSSSRVAMVARESDVARVHKRRGFERRDTTAKTVSFRRVVARLCSWQHYHCGHEGRRSGDTGAVAVLPTPSSSASPAPLCPGVQGASSSSSATQKESTREPERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDK0</accession>
    <name>A0A084VDK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00003071</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01011556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524695">
        <property type="protein sequence ID" value="KFB36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDK0"/>
    <dbReference type="STRING" id="74873.A0A084VDK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003071-RA">
        <property type="protein sequence ID" value="ASIC003071-PA"/>
        <property type="gene ID" value="ASIC003071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003071"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011436"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="329"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="734" mass="82111" checksum="09D8FA07E13BEAE5" modified="2014-10-29" version="1">MNGFDDVGVFFSDNFDGDQQQNENQINLQQVKKKYREFIRTFCEANFSYKYRDALKRNYLLGRYYLEVEIEDLAGFDESLADKLYKQPTEHLQIFEEAAREVADEITSPRPEGEEQVHDIQVLLGSGSNPTNIRDLKSDSVSKLVKVAGIIIAASGIKAKATRISIQCRSCSNVIPNLPVNPGLEGYQMPRKCNTEQAGRPKCPLDPYFIMPDKCRCVDFQVLKLQELPDFIPQGEIPRHMQLFCDRSLCERVVPGNRVMIHGIFSIRKIARQGKADGREKQIVGVRAPYMRVVGISVDTEGKGAISRFNNITTEEESTFRKLAASPNIYETLAESLAPSIFGSQDIKKAIISMLFGGSRKRMPDGLTRRGDINILLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVIRDPATRNFVMEGGAMVLADGGVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGDENIDFMPTILSRFDMIFIVKDEHDQKRDITLAKHVMNVHMNASKANPAEPKEGEIPLATLKKYIHYCRTHCGPRLNEPAAEKLKSQYVRLRAGVGEHERATDKRMSIPITVRQLEAIIRISESLAKMHLQPFATEAHVSEALRLFAVSTMAAANSGSLAGAEGFTTEEDTEVLNRIEKQLKRRFAIGSQVSEQNILADFARQKYPETAVRKVIHTMIRRGELQHRMQRKMLYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFX4</accession>
    <name>A0A084VFX4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00004045</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524804">
        <property type="protein sequence ID" value="KFB36868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFX4"/>
    <dbReference type="STRING" id="74873.A0A084VFX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004045-RA">
        <property type="protein sequence ID" value="ASIC004045-PA"/>
        <property type="gene ID" value="ASIC004045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004045"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012913"/>
    <dbReference type="OMA" id="TINCYIF"/>
    <dbReference type="OrthoDB" id="7722793at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17243" checksum="A66D3D8275ED72BD" modified="2014-10-29" version="1">MCLKINNQLVTVAESLRKYPPVPMHMRMTTKDYSVPGTDSTLVAGTPVFIPIYAIQRDPDLFPEPEKFDPDRFSAEEEAKRHPFAWTPFGEGPRVCIGLRFGMMQARVGLAYLLRGFRFSTYEKTSIPMEFVPNSFILAPKDGLWLKVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGV1</accession>
    <name>A0A084VGV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Succinyl CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004423</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004423-RA">
        <property type="protein sequence ID" value="ASIC004423-PA"/>
        <property type="gene ID" value="ASIC004423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004423"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10046" checksum="F89F8F70E85CF593" modified="2014-10-29" version="1">MLGPTEHCTIRENRRTPPIATWLCPSPMDDPLLASVRSTSDRSHSKALTDPAAGERKTPTAAAAAGTERQAHVQHRPLVDSWFELWKCASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH01</accession>
    <name>A0A084VH01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP000830-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH01"/>
    <dbReference type="STRING" id="74873.A0A084VH01"/>
    <dbReference type="MEROPS" id="C14.015"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004461-RA">
        <property type="protein sequence ID" value="ASIC004461-PA"/>
        <property type="gene ID" value="ASIC004461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004461"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014730"/>
    <dbReference type="OMA" id="HFTANHC"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990525">
        <property type="term" value="F:BIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF245">
        <property type="entry name" value="CASPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="66"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="210"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="309" mass="35483" checksum="F89C88FA1BE6B0E9" modified="2014-10-29" version="1">MSIPDVVDIIKNVDKELVDRESVMERPADVGDALGTRKAHEPFDPRLCARMPVDRYAADYNMKHKRRGLALIFNHENFDVPQLKMRAGTNVDCENLTATLKGLDFDVHVYKDLKLRDLQKEIERASQMDHSDADCILITILSHGELGYLYAKDCQYKLDVIWSYFTANHCPSLAGKPKLFFIQACQGDQLDGGMLLSPKDRTETDSASSMTFKIPTHADFLIAYSTIPGFYSWRNTQKGSWFMQSLCHELNQHGRKYDILTLLTFVAQRVAYDFESNTPDIPMMHQQKQIPCITTMLTRLLRFEEKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHK1</accession>
    <name>A0A084VHK1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">[FeFe]-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004580</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHK1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004580-RA">
        <property type="protein sequence ID" value="ASIC004580-PA"/>
        <property type="gene ID" value="ASIC004580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004580"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004580-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21419" checksum="F5D807D5711FE675" modified="2014-10-29" version="1">MSIRPRTGWKNRVRGEKYAAYGVGKWEVMLIDRSMQWTVGVFMQRPRDLATLSDALLIVMSTLDATMVALMSNRNQTTGTRKETPTSMRGGARSVRPERPPHAVGQATNPQPQLATVGSHVPPVAPGVEREKRVKLANIPCQLTETQAHRPEMTKFEPESENMYQHAWKAVPASRKTRQRVLEFGEQVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHL1</accession>
    <name>A0A084VHL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001974-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHL1"/>
    <dbReference type="STRING" id="74873.A0A084VHL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004591-RA">
        <property type="protein sequence ID" value="ASIC004591-PA"/>
        <property type="gene ID" value="ASIC004591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004591"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020771"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15183" checksum="717D7F9803CF1811" modified="2014-10-29" version="1">MDTNGSMYSDESLSPTNVTAADQCTTKLPTVQEYLDGLNYPIALIIVSTVILSIATISIFFKNAYHILHRTPKQFKTKSVLLLTIYPLITLFSVVSIAVPRAFFLCDTVMHVYFMVCAYVFFGLVGNGGWLVPVGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI95</accession>
    <name>A0A084VI95_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enhancer of split mgamma protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004938</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013336">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524853">
        <property type="protein sequence ID" value="KFB37689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI95"/>
    <dbReference type="STRING" id="74873.A0A084VI95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004938-RA">
        <property type="protein sequence ID" value="ASIC004938-PA"/>
        <property type="gene ID" value="ASIC004938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004938"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024459"/>
    <dbReference type="OMA" id="NEPIWRP"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19741">
        <property type="entry name" value="bHLH-O_ESMB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000072">
        <property type="entry name" value="enhancer of split mgamma protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26969" checksum="C3030FA32D6B1EAA" modified="2014-10-29" version="1">MDYANMVSESSLNGKLQSSLEPVSRTYQYRKVMKPMLERKRRARINRCLDELKELMVSALQSEGENVAKLEKADILELTVRHLHKLRRQQRLAANPVIDADRFRAGFTHAANEVSRCLASTPGVDIKLGTKLMTHLGHRLNDLDKVSPLSVHVESPGSPSGAPNSASPPISPFSGASSSAGDVPMYPMPLTPQSYRSEESSSLLLAPSTTPSPNPSECDGEHHHHQTTGLLKIQQSGCEAVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIC4</accession>
    <name>A0A084VIC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011666-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005026</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005026-RA">
        <property type="protein sequence ID" value="ASIC005026-PA"/>
        <property type="gene ID" value="ASIC005026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005026"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9143" checksum="69DAA2EAC85B58F7" modified="2014-10-29" version="1">MQCSEFTVRHACGDETALFTRKFLDKMSNTLMRRHAYQFRSVEFLIKYLRAGPNGATLPAYENVNLIAPTNTKADDRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIW3</accession>
    <name>A0A084VIW3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00005228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013412">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIW3"/>
    <dbReference type="STRING" id="74873.A0A084VIW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005228-RA">
        <property type="protein sequence ID" value="ASIC005228-PA"/>
        <property type="gene ID" value="ASIC005228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005228"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010542"/>
    <dbReference type="OMA" id="CSRFIAP"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB37907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="14292" checksum="B013BADF79BFE55E" modified="2014-10-29" version="1">MFVSSAARIAPVARSLVLNGTKAYIRPISSAIISQSQTLAAQNTAPVALLPQVRSFQTTPVTRDIDSAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMMAFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJT5</accession>
    <name>A0A084VJT5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003096-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00005544</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJT5"/>
    <dbReference type="STRING" id="74873.A0A084VJT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005544-RA">
        <property type="protein sequence ID" value="ASIC005544-PA"/>
        <property type="gene ID" value="ASIC005544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005544"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006779"/>
    <dbReference type="OMA" id="FLEYPGH"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF10">
        <property type="entry name" value="L-DOPACHROME TAUTOMERASE YELLOW-F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783571" evidence="5">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB38229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="432" mass="49329" checksum="02C69ED51B88CA54" modified="2014-10-29" version="1">MCWKVIALCCLALVVVPIRSDEFEEVFRWKLLDFNNLTDAEEAAPGIFFPEEVDEPTTNGLNESFTRYHNLPMGVTHHKGRLFVTVPRRRTGIPSTLNVIVLDQVPAGEKSPRLTAYPELITNELRKSYEPDPKRLVSVYRTRVDRCDRLWFVDTGFLEYPGHRKQVQRPALWIIDLLQDRKVRQFEIPESIVAEGHGMASLTVDSSADDCEAAFAYIPDLAFYRLYVYSFKENRMWKFQHEFLSFDPRMTGFGVAGVRFRWNDGIFSVALGPPAGTNAADGRKVFFHAMASTSEYQTTTPVLQNETLAKVGGYDHLFTHLGERGIKTQCTIHQYDPATGVLFYAEVNRNSIGCWNSAQRFEPENHGIVHLDNRNFIYPSDMTLDSDGELWVMTNTLPRYAYAKLDTEEYNFRIWRQQPAKAIAGTICAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJT7</accession>
    <name>A0A084VJT7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005547</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJT7"/>
    <dbReference type="STRING" id="74873.A0A084VJT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005547-RA">
        <property type="protein sequence ID" value="ASIC005547-PA"/>
        <property type="gene ID" value="ASIC005547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005547"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007260"/>
    <dbReference type="OMA" id="INCKGIK"/>
    <dbReference type="OrthoDB" id="6625921at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF129">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005547-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="452" mass="51362" checksum="4FC3AD296C736098" modified="2014-10-29" version="1">MVIKESEFDDSLAYALLRGDMGTVWDTSKDERMVNGTMDPELIQRAKERAIRAQLNSADGDTCETHDQFYRDHKLLLVLFRGLAVMPITRSVPGRITFSWRSAASLYAFCFYTVSTVIVLIVGYERIKVFQTTTQFDEYIYGILFVIFLVPHFWIPFVGWGVAKQVAIYKTMWGAFQVRYYRVTGTSLQFPHLKVLIVFLSIGCLVCAIVFLLSLSFLLEGFALWHTSAYYHIITMLNMNSALWYINSRGIRVASSSLSRCFRKDVAIECTAAMISQYRFLWLNLSELLQSLGNAYARTYSTYCLFMFVNITVAIYGALSEIIDHGFGFSFKEIGLIVDTVYCSTLLFIFCDCSHNATLQVAQGVQDTLLSINLLKVDQPTQKEIDLFIQAIEMNPAIVSLKGYAEVNRELLTSSIATIAIYLIVLLQFKLSLISQQIPAEIIENVRQLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX9</accession>
    <name>A0A084VJX9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00005603</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01013952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524913">
        <property type="protein sequence ID" value="KFB38273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VJX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005603-RA">
        <property type="protein sequence ID" value="ASIC005603-PA"/>
        <property type="gene ID" value="ASIC005603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005603"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007326"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014558"/>
    <dbReference type="OMA" id="HESHVPL"/>
    <dbReference type="OrthoDB" id="6244905at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052615">
        <property type="entry name" value="FGFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890:SF10">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="113"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="540"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="633"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="828"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1365"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1092"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1367"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1397"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB38273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1442" mass="160249" checksum="D8B8B788712AF087" modified="2014-10-29" version="1">MRMTCGIKEHHAYHMNSSDVQWYFKPCGGGFHQMACSNRAELDEHDWHPLNCGDKRCHVTLTVQNASEADAGLYRCTIHPYRTDNQTQLDIQLVRTFQLIVTKSFLDESIPAPELLDNLPANTTAIVDTQIVLQCRVHSKVQPTIKWFRRINKQLGEHSFNQNKSIRYLENFYELLPSAGEKLLSHDVYLSKLILYSASERDIGIYVCVGINYGGVSMADAYVNLLHANGTPMEESHGGYVDLMVLFLIPVALALVPLVAWIVLNVLRASHHPEEKGLVSLNSASIYEPAITAQSDKKDANKERKTITRSNHSPSERFSNITRRTKTRRTENLPAVKQNETAKQRHTISIVDCSIISLDGSTNDSGVALKSQNPPNPTQTRRRATRTKAGAIEPQTNAIEMSTENVQTRRSNALKRKQESSVPDTGVSPPKKVLEDHVSIVEISVDREEGTAQEIAEHQTIEATVSTTTTHIQSVPKPDGNASKKLPIDPFKALIVSVKRVGPALTETELKSLKYYDPGAPKDAMMNDNHRQSALVTEIDASLERHSSERNRNVSERKRRFSRLSLSTKPQIIVSAPTTESSLPADRSETDTNGNRLLPPGGKKEQKKIKPSPLSYAIEEEDIGEDVYEFQSCSQTSETLGKSKVRKKPGRKPKPKTGAAKPAKKKKPVATVGKSTVSWKPGHNNPFGCNRKQLANVIKHIGGGPVKPPVTVDYVVNLELPATPQPIVDRGGRGENDRDEIIDLPYQAPPVVPKHPTVEKLKYGSALLQQPQTSTPMNKPTEPAPTPPSNPVSPWRLQDDNIIIPRTSYVPRNKEMLPSYDSFFAVEDNNGSNAPPTSNAPVSLVTERRKPPSGARQIAPTLTDRSFNSPASNSQVNDKEMRELERMYLKLQAKMEMSKRLINSLRRNKAIPGLQNCPEHRTNVKEACLKMKQWYKDSKKDFHRSLHIVNKIHRANVTGQTASCPSPLTTDQQRTVECFNQSSDRFRTMIDEMQAVMNDSNVENCSPPSSPKQAKPSSSSSLQQPSQQPSKVSDVIILPARLTHGATRNPLMPLNFVPLPQRTSPLISPLAVADRGIASAAKETAPVAGENNIRRKLEYENTNKERQEEQERVTKEPPATDTAEHTEPESNVLEDVNHSAHPILDVGANEVVKDGQLSTADSSASIDNCFGFDEDERSQESTQVTLPLPANISSNTLKQSLAKVRQFIPKQPIFRQQPKPTPSTSGGGPTRLPTVKLRVFGSPTRRPSHTLREFVASTPRAELSQLAATANTPSAGPSKGTQLLAVERTPHGQHGIALEAPDISAIERLNTTVPAKQHPNDGNEPEVVLFDTPEESHIDRSTLHRTYARVPRRRRKNRNIYLANLGLDDDEDDEDDEGEGDAPEPVDSDSDFGSGNTRKKKDRTKKPRRKPKPVEETAAFKQYVETFNNMYERVQRFEPIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKH8</accession>
    <name>A0A084VKH8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Two-component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005874</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKH8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005874-RA">
        <property type="protein sequence ID" value="ASIC005874-PA"/>
        <property type="gene ID" value="ASIC005874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005874"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10124" checksum="D231723905C082C5" modified="2014-10-29" version="1">MCEQRFATPFVCGGTKGVRETLLGNGQDAVDDCPRNECTVLVSGRQKRSKACAHSSDGFANVGSSMQKQALLGKGPGMAEKVPANAFETTLMLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN75</accession>
    <name>A0A084VN75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Manganese peroxidase H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006995</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014722">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006995-RA">
        <property type="protein sequence ID" value="ASIC006995-PA"/>
        <property type="gene ID" value="ASIC006995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006995"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10699" checksum="D592D4E294344D2A" modified="2014-10-29" version="1">MAQQSGCGKAVCKPRGKPWRTAYCCAEISVRRRLAAAAYTARCTSVAHAMSRFAYHPIILLSGHDGTGTGNRPPTAHRGLKLVAAYEPGASANSLAMLGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNA8</accession>
    <name>A0A084VNA8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ATP-binding cassette sub-family C member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006944</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014733">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006944-RA">
        <property type="protein sequence ID" value="ASIC006944-PA"/>
        <property type="gene ID" value="ASIC006944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006944"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006944-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="16401" checksum="ED3FE575F8A742F2" modified="2014-10-29" version="1">MAGPRWRRRVIEKLNGLPDAPETGHQRDTFLRTGSSPAEVRILAWLPDFGTRKLFNALSGSTFRNVAAAWWHSNFPQILHKCPPKAHRAIVAYNFIRLAAMDARENARTSSPFGRNRRWNSHDTSIGFLHACPEGGGRRERGIGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNM9</accession>
    <name>A0A084VNM9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002040-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524988">
        <property type="protein sequence ID" value="KFB39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNM9"/>
    <dbReference type="STRING" id="74873.A0A084VNM9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007021-RA">
        <property type="protein sequence ID" value="ASIC007021-PA"/>
        <property type="gene ID" value="ASIC007021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007021"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001311"/>
    <dbReference type="OrthoDB" id="10626353at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="277" mass="29139" checksum="102F6C7862B1CC5A" modified="2014-10-29" version="1">MELRFLPNTLVEGDPAVPGVAAAASVTGRPEGGWRRQKKQQHTTERRGPEEEMAPPLEGDGGNDGSGEGDGDGDVATNVTGTNNNNHQSIPNQQQHHLQQQQQQQQLHLPSGGLPPMHHPATAAMNSCGVPTIGGPTATLQQQQQQQQEQMMLASMPHRRTLERSVRTIPNGGSGGGTPTMMHEAGGGAGEMGGHPPGRNSSIRRTRRGSGSVPGSPRIGRGPSSEFLQQQQQQPAGVTVVARSPMPMRAAGVKRNAAARLGRAENMSSGSLNSIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNX6</accession>
    <name>A0A084VNX6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00007120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01014940">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524996">
        <property type="protein sequence ID" value="KFB39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNX6"/>
    <dbReference type="STRING" id="74873.A0A084VNX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007120-RA">
        <property type="protein sequence ID" value="ASIC007120-PA"/>
        <property type="gene ID" value="ASIC007120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007120"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017092"/>
    <dbReference type="OMA" id="FPYNTWG"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002875">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000576">
        <property type="entry name" value="CBN-SEK-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="57"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="378" mass="41731" checksum="4D2005CC15F45C8B" modified="2014-10-29" version="1">MNARKGKPNLKVKLEPSSSGSGSSVPDSAENATPRNLDKRATLTVGERSFLVEADHLRKLADLGRGAYGIVEKMLHQPSGTVMAVKRITVTSGMGAAGGAGGGIQSQEQKRLLMDLDVSMRASDCRHTVQFYGALFREGDVWICMEVMDTSIDKFYPVVYKRQGRTIPEHILASIARAIVRALHYLHMKLSVIHRDVKPSNVLMNRRGEVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIDPTRSKAQGYDIKSDVWSLGITMVEIATGKFPYATWRTPFEQLKQVVTDEPPRLPQRAAPGSDEFSAEFHAFINSCLQKDYQQRANYEQLLAMEFMKRPDDGDELAEISDMAQYVCAILDERDGPLGDGGSSSNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQL2</accession>
    <name>A0A084VQL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP003294-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007719</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525004">
        <property type="protein sequence ID" value="KFB40256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQL2"/>
    <dbReference type="STRING" id="74873.A0A084VQL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007719-RA">
        <property type="protein sequence ID" value="ASIC007719-PA"/>
        <property type="gene ID" value="ASIC007719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007719"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012434"/>
    <dbReference type="OMA" id="DHDFAID"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="813" mass="93227" checksum="665C062B32FA5C85" modified="2014-10-29" version="1">MKESKKQKAPSGKKPANGAQPTVTNPRQEKAGGNVGVSSKIWDDERFAHLINDPRYRGMPKSKKKVQIDSRFKAMFEDGRFNERATVDRYGRKLRRTQTDEMKKFYELEESDDEEKAQRERELEERAMEGRMEEEEQEKDTSGSDSEAESTDGLELNEDEKKMDIPTKIKKRLKNLEIDYARGEGVLLTESSSDEDSDEDGEGADDDDEVFIEHVWGELDADAERTEETTKRLAVCHMDWDRIRAVDIMVLLNSFLTPGSTIKSVTIYPSEFGKERMQEEEKRGPQELTSRVLEDSEDEADDDEEAQKERLREYQLNRLKYYYAVVECDSAETADKIYKECDGVEYESTANKLDLRFIPDDMEFDDEPKDHCTELPDMSKYVPRIFTTSALTQAKVELTWDENDPDRKEFNEKIRDGKWAQMPESELKKYVVCSSSDEEDEEEKGKTNGKSKKRPLVLLRAPEEPSSGSDEGESSDSDGEPKGRRKEDMIAKYKALLNEVKEQSRSDDKVEMEFTWNVDGDGKDKGKAADSEQDDDDDDDSDGGQQHQHRGRSKSLADDVNPFEKILQKKKEKAKRRKELKKRRKRGELQDGSDDGEGDDSSDDDTPYGVDLNDPFFASAFDENEFDLGKKKKSKKKDREALQRSKEQEEQEAAEEARRKAELELLLDDGEDDSRAHFNLRAIQESEIDLKSVSKAKRRRILKKSKQEIEEKRNAKQAVTDDFEVNVEDDRFGAIFSKAEYNIDPTNPAFKKTKGMDRLIEHKLKKRRLAENDMPAEAGVSVAPEQAAGKQVKKDVATTMLVKSIKRKIGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR08</accession>
    <name>A0A084VR08_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002192-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007885</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015393">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525011">
        <property type="protein sequence ID" value="KFB40402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR08"/>
    <dbReference type="STRING" id="74873.A0A084VR08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007885-RA">
        <property type="protein sequence ID" value="ASIC007885-PA"/>
        <property type="gene ID" value="ASIC007885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007885"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022297"/>
    <dbReference type="OMA" id="PWSCDYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="385" mass="42470" checksum="6F890A24F6421147" modified="2014-10-29" version="1">MALRMFRLGQDVVTPLIKRNCAVSAFELQHKNPVQRKVEVIPKAQYGGRHTVTMLPGGGIGPELMSYVREVFRFAGVPVDFEIVDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGILSRNVALRNELDLFVNVLHCKSFNAIPAHHSNVDVVIVRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARFAFEFAKNNNRKKVTTIHKANIMKLSDGLFLKVAKDIAKEYPDIQHNDMIIDNCCMQLVSNPHQFDVMNTTNLYGSITSNVLCGLVGGAGLFSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAMLNAAVDMLYHLGHRYHADCISDALHKTIDIDGVHTPDLGGNNTSTDIVQNVLKHLAEKRTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRL1</accession>
    <name>A0A084VRL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006417-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008115</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRL1"/>
    <dbReference type="STRING" id="74873.A0A084VRL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008115-RA">
        <property type="protein sequence ID" value="ASIC008115-PA"/>
        <property type="gene ID" value="ASIC008115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008115"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005617"/>
    <dbReference type="OMA" id="IVCNFAR"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783808" evidence="5">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="66"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="242" mass="25850" checksum="B1B6657AA5F6DB73" modified="2014-10-29" version="1">MADTVSKLIFSCFVLSAPAPAPGPAAVNYCENSFCPAGVKNIGCDPPPITGGSGCTDFKIIDLGQAEQAMIVDYFNGRRNFYASGARSPTFPQAQRMLKLTWDAELAQQANYKSRTCSSVTDDCRNTAKYSNVGQFTNELGLGEDTTEAYLQMLLFTASIINYTKTQAPSDWSNILNDKAVAVGCALSVYTDEGVSWKLFVCNFSDGGIVGSNVYVAGPTASLCTTGTDQFFSNLCSSAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRY5</accession>
    <name>A0A084VRY5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001909-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008154</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRY5"/>
    <dbReference type="STRING" id="74873.A0A084VRY5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008154-RA">
        <property type="protein sequence ID" value="ASIC008154-PA"/>
        <property type="gene ID" value="ASIC008154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008154"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013745"/>
    <dbReference type="OMA" id="TFRSDWW"/>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02677">
        <property type="entry name" value="MIT_SNX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06881">
        <property type="entry name" value="PX_SNX15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051866">
        <property type="entry name" value="Intracell_Sig-Traffick_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508:SF8">
        <property type="entry name" value="LD24550P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="427"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="843" mass="93838" checksum="8A6635EAF8F58FE4" modified="2014-10-29" version="1">MLVGRRKAETWVHSFSVGSETRKYKGFTIYRITSIVFPRSAPEALTRVTLWKRFSEVKRLYKELARRHRERHLPGTIPALVEQSYFKRFDPAVIEERKRYILQLLEWAGQEPALYLSHAFVSFFARGISPDEGETESLDGGTLAVKENGTSDKSDVGNIETIRQTLGIRVRDELSLIDPSRDGETTATSSTSGGEEEEENVATDGPTMAKGSSPMNGSMVSSLISETGSLQSEEKSTVGQQLEKMPPEETMDYLVAAAMVFSKAVEAEANGEYQLAFEHYKAGIDRLLSGAKDDTNVTRRKIAKEKSCKYVSKAEEIYERHLQQTGADGGSASQTLGPISYEDPSSPIQLLERPLNYLSRYKVVKVIGTVMQVQDVTDKKFYIMKSIRRPPPATGGTWLSSAAVFPQDVPYMVPLVAYFHSTDGSIFLLLRLVCAGKLWDFIRTYRKQESYCPTPEELAKLTTEDERRENSLTSEGPSIKFESDEAPPPVEESVMKDANSSGCDSGFLELVNECSGEYNESAILKTNNDASLHDENDMDEVAIEAHPDVLQQEDEQEIVIPSFDALSKDMDVRELVSCSQQLLKAVTQTLEESEPNAKTKSVPLDPPAIPEPAPMADCSHSGNRSEKMSNSIDSKEQTKSHSSQLGLVGVASIISEVNCGGDSGNTPDLLPEGSVRRWISELVIAVDSLHFNGIVCGDLTMDNLLLGPEGQLILTYFHRRGESYFSQAGISPIAPKHTAVRELYVAPERPLEPKSDFWSVGVIMFEMLTKRKFVSCHPSGVFSYHEVQYPEGVDLSDDAKELLEELLQPDVERRYDFKQIIASPFFRSVDWSEVKRRGQISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS67</accession>
    <name>A0A084VS67_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00008246</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01015825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS67"/>
    <dbReference type="STRING" id="74873.A0A084VS67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008246-RA">
        <property type="protein sequence ID" value="ASIC008246-PA"/>
        <property type="gene ID" value="ASIC008246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008246"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024522"/>
    <dbReference type="OMA" id="MAHAAWL"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB40811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008246-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="569" mass="65139" checksum="1AB515DBC2402B85" modified="2014-10-29" version="1">MRMESNGGNSGGTSPKRRTNVVGNGKSNHRHHQHHHQHQHHQQHHYVNNQTDPSVLDGGADANPTSSTELPPSSGSFLHISIIKLALGSRLLVIALQIVANQLMPDHDAGVFIAPRDKDAPDRPLDAFVRFTLGGLDRWDGQYFLHIAEHGYTYENTLAFFPLFPFILKIVSSALNSTDVITFISYRELSLVLAVLFNMVCFTGAAKALYRLSKLVLGSKKKAEIAVLLFCFNPASIFFTAPYTESLFAWLSFAVMYQCIEDVTSVFITIPLSLSILSRSNGMINIGFVLYFAIRRIVAQYNFHNVICICSRLFTMLIIVLFHYGIAQVYNYYLFCFEQKFNFPAHVREYASEHGLILAGNKTEDSSPWCTNLLPLSYSYVQSHYWNVGFLRYYELKQLPNFLLALPAIYLTLSNSYHYLQEHWEYAVRLGLFRVSKKQFKMMRPYDRLALVFVVHAILLTLFSLFFVHVQVTTRLLCAASPVLYWYAAEYFTGERTFIKRQVIRKLSKQVKDGDENSCTHVTNHVDLSDLLDIRCMNWQQQAILWYFVGYTVVGTKRKEPCAWNETGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSY6</accession>
    <name>A0A084VSY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008535</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008535-RA">
        <property type="protein sequence ID" value="ASIC008535-PA"/>
        <property type="gene ID" value="ASIC008535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008535"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8456" checksum="D73FBEEAC6A86914" modified="2014-10-29" version="1">MGSRRRLALINKVVCSPFARFAALVCREGEMAAVPRILSRRPQGFTTTHASLRDGGSGYGQVNSRHAQWDACTVVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV19</accession>
    <name>A0A084VV19_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">4-hydroxybenzoate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009600</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV19"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009600-RA">
        <property type="protein sequence ID" value="ASIC009600-PA"/>
        <property type="gene ID" value="ASIC009600"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009600"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009600-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7351" checksum="EE68370FC96C62F2" modified="2014-10-29" version="1">MDVPGCNCPVRSGFAQFGTMTNEELPISARLKRTNLDEHPEPERGYIQLTSAGRLHKIDVAGKIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV67</accession>
    <name>A0A084VV67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000769-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009705</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV67"/>
    <dbReference type="STRING" id="74873.A0A084VV67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009705-RA">
        <property type="protein sequence ID" value="ASIC009705-PA"/>
        <property type="gene ID" value="ASIC009705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009705"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020284"/>
    <dbReference type="OMA" id="CIKIPRD"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="136"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="298" mass="33328" checksum="AEC408222BDE0AFD" modified="2014-10-29" version="1">MASGTNGRVTVAPYGDNNNQQHKPAEATLNGKSASREANGLVPGAKSHPARDEDRSARQSLIILVAIFLTSLFAMLYVYAMFPELDESEKQYLKVPFDIDDAKQLGRVLDRYKDLYNLEVMFGIILVYIFLQTFAIPGSLFLSILSGFLYSFPVALTLVCFCSALGATLCYLLSQLVGRRLVKYYFPERAHHWAQQVDRHRDDLLSYMLFLRMTPFLPNWFINLVAPVIGVPLYPFALGTFLGVAPPSFIAIQAGKTLYKMTSSSDAFSWGSIAMLAAFSVVALVPVIFKRYFKTKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWU7</accession>
    <name>A0A084VWU7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010141</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWU7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010141-RA">
        <property type="protein sequence ID" value="ASIC010141-PA"/>
        <property type="gene ID" value="ASIC010141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010141"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011871"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="13806" checksum="005699B965A8275D" modified="2014-10-29" version="1">MSVSASFGGPFGRSTRTKVPYFRKSKAISHKTEQFVFKDSQEPFGAAATTNAGADSSIAALLDWIALFLGLIRFALDAVDESDGIYADCFSHAFVGDTIEGLVVFMLASCRSTSANIAKRVKMSVDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXH7</accession>
    <name>A0A084VXH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004891-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXH7"/>
    <dbReference type="STRING" id="74873.A0A084VXH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010404-RA">
        <property type="protein sequence ID" value="ASIC010404-PA"/>
        <property type="gene ID" value="ASIC010404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010404"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018194"/>
    <dbReference type="OMA" id="IKTRICM"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024201">
        <property type="entry name" value="Calcineurin-like_Pesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035808">
        <property type="entry name" value="Pdiesterase_Brain_239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="298" mass="33450" checksum="2470331BD296540D" modified="2014-10-29" version="1">MKIDIHPLTHDPTSAWKEISKSQRVIKINTKPPAAEVPANKVRVVCMSDTHSLTHHIKFDIPDGDIFIHAGDFTRCGKLDEVIDFNEWLKKLPHKHKLIIAGNHELSFDNTFTHPFQNASACCKKTGSTLLDEIPTLGNSKESLAEAVKTENIRQYLSSCVYLQDEAIELYGLRIYGTPWQPEFCKWAFNVKRGQPCLDKWEQIPENVDILITHTPPVGHGDLCCSGVRAGCVGLLATVQQRVKPKYHVFGHVHEGYGITSDGRIIFVNASTCDINYLPNNQPIVFDVTLPKGRTKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYC2</accession>
    <name>A0A084VYC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010840</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010840-RA">
        <property type="protein sequence ID" value="ASIC010840-PA"/>
        <property type="gene ID" value="ASIC010840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010840"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6332" checksum="CAF8E509B9A221D5" modified="2014-10-29" version="1">MGSCIDGGLEKPNKTSPNARATSWFRKVWNGCVARSKSKPDPVPSRLGRLRTVYAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYF0</accession>
    <name>A0A084VYF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Rho GTPase activator (Rgd1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010871</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYF0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010871-RA">
        <property type="protein sequence ID" value="ASIC010871-PA"/>
        <property type="gene ID" value="ASIC010871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010871"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8862" checksum="B071842CCEAAA8C7" modified="2014-10-29" version="1">MCHYRGHPVPWNTHGSPSPSLPDLSFTGSFANAWKAQRLSDVGNELDCSRGLPYGIPDANASSVRWLVPYLRRSIVQVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ13</accession>
    <name>A0A084VZ13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptidase S66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010991</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010991-RA">
        <property type="protein sequence ID" value="ASIC010991-PA"/>
        <property type="gene ID" value="ASIC010991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010991"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="6948" checksum="FCF1F559D5160000" modified="2014-10-29" version="1">MVIVKALSGHSHSGCFSSPRTPWKLQVTSGAVNLGRRSHPNSGPVTLHRGLVQTTVLSGDAVTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ17</accession>
    <name>A0A084VZ17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011035</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ17"/>
    <dbReference type="STRING" id="74873.A0A084VZ17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011035-RA">
        <property type="protein sequence ID" value="ASIC011035-PA"/>
        <property type="gene ID" value="ASIC011035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011035"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013928"/>
    <dbReference type="OMA" id="KQQLWPG"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000002">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="355" mass="39658" checksum="1B869AD749E274BE" modified="2014-10-29" version="1">MAFQPGAPRNRTPLAELPTVPGMTMEAASPEQGAATRRRALTPRVIDSPSANIPDSIMTPTLSPEEDVIRQRGRRRTTIMWSPDHNRSVFLSPMKTPTKNISSMTLRSSPRKRSLMQELSDVAVPSTSAASPSKRVLGARLSVTDSPGSSTKRVKVEESAMNRQNEAIPLETILKGYSREQLIAVIGLLVARDEQLEATVRNELPIPDIAPLEGELIKQKKNIFASVPNQKFLSRTDGHGYLRAATHLATFKQTVYGQSQNLYTSRHWDALLDYVMMAWTHVRETPVYENAKHNAVRRYCFKLLSHHASNALKHGSTALGRDRVVRFQHKLTGMASDWAEVNECGKCIEYIMKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ49</accession>
    <name>A0A084VZ49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018601">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011021-RA">
        <property type="protein sequence ID" value="ASIC011021-PA"/>
        <property type="gene ID" value="ASIC011021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011021"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011021-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8086" checksum="8C0470A44055B2F5" modified="2014-10-29" version="1">MASGRHQSGGYHQEGKKENGTPDVSLPRQKVTRSTTASCALAGKAWQKGQTEAIRRRSPPPHVSVWWNFNLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZG1</accession>
    <name>A0A084VZG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001742-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011150</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018765">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018766">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZG1"/>
    <dbReference type="STRING" id="74873.A0A084VZG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011150-RA">
        <property type="protein sequence ID" value="ASIC011150-PA"/>
        <property type="gene ID" value="ASIC011150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011150"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019087"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF2">
        <property type="entry name" value="IP09356P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011150-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="275" mass="31768" checksum="5E2D7EB360966356" modified="2014-10-29" version="1">MLDSCFRNSSPTIAVELLYSVKIPDSVEEISDRCLLFNRGMECVQHYLNVCVDQQERKIIENEVYGAKRLYEFLCRDRSYQQESAQQSLGALPEPVCGQISQMLDSCFRNSSPTIAVELLYSVKIPDSVEEISDRCLLFNRGMECVQHYLNVCVDQQERKIIENEVYGAKRLYEFLCRDRSYQQARFFHRRFMFALPSARYGYENCVANSARHKCRPDSALFLRTVARLLSTDRHFLNCDKIEHEVCSSGTRAATWRVLLAAASLALLLLAAIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZM2</accession>
    <name>A0A084VZM2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011214</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011214-RA">
        <property type="protein sequence ID" value="ASIC011214-PA"/>
        <property type="gene ID" value="ASIC011214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011214"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6225" checksum="B5D45D1A6560FE0C" modified="2014-10-29" version="1">MAYGHVLQMAECCAAPLCQEPSESRKNRASMSPISCKVAQFCLRARFSNNCPKTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W070</accession>
    <name>A0A084W070_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001137-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011554</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W070"/>
    <dbReference type="STRING" id="74873.A0A084W070"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011554-RA">
        <property type="protein sequence ID" value="ASIC011554-PA"/>
        <property type="gene ID" value="ASIC011554"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011554"/>
    <dbReference type="OMA" id="YYRAAVV"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011554-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="273" mass="30619" checksum="EC283AA5A577C1C1" modified="2014-10-29" version="1">MATGSYLLDVGVPSILLIATTGSVVKLSHMLGQRNRITKISSSVQYFDNTIQRLDFRMRCDEVNQWLTGLVAGFCIATVLLSIATAIFGNMVFNKTSTILLVAFIDVSNIPYIIFLILFMACELSVRCRLKLLCTLVKNGLTLTASKARKDIVMLHHLVAGITDLHNVLSAIVQHINALFLVEVFMCLAAYTSLLIFTLFSYYRAAVVMGETEYNFAWLTIAWSIYNSLFVLPTILFGAWARIESKRFSKLVHLMLRTTNDNLLQDQVGKLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0N3</accession>
    <name>A0A084W0N3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011634</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0N3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011634-RA">
        <property type="protein sequence ID" value="ASIC011634-PA"/>
        <property type="gene ID" value="ASIC011634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011634"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8355" checksum="726CD0B814DAFCB7" modified="2014-10-29" version="1">MARNVALLQNHEAVPRQREAAAVGLREAELGLERARREQRNYRARARARQGPAQRGQGQGRRAEQVPENVETAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0S9</accession>
    <name>A0A084W0S9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Alpha-N-acetylglucosaminidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011668</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0S9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011668-RA">
        <property type="protein sequence ID" value="ASIC011668-PA"/>
        <property type="gene ID" value="ASIC011668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011668"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10610" checksum="2776C326701E0814" modified="2014-10-29" version="1">MGCLGRGKKNSGTLGGWGRTLDHSQKWLGQIAIGPRQYVSRICTVSLAPAGHTECGVAFSAGGRQPPLGMVGIFGDDRTTNTTGIPHECETFCPRKSPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W129</accession>
    <name>A0A084W129_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006926-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011748</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W129"/>
    <dbReference type="STRING" id="74873.A0A084W129"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011748-RA">
        <property type="protein sequence ID" value="ASIC011748-PA"/>
        <property type="gene ID" value="ASIC011748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011748"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001638"/>
    <dbReference type="OMA" id="STWICND"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01167">
        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="259" mass="27785" checksum="F7C702BF7946A381" modified="2014-10-29" version="1">MSLQGKNAVVFGGCGGIGFAICKHLLKEGVQKLCILDVSELSEPNRMLLKDVNQQAELVFKHCDISKRTMLQKTLQEDVVGVLGTIDLLVNSSGIATADVLDSVIDVNLTGVINACLFTLDVMSRAKGGIGGVIVNVASIAGLEPIAFLPVYCASKYGVVGFTRSLGVPQIYDETGVKFITICPGATRTRLFENCRSASMEMVALKQLFQDYLTRFVAQSPDAVGACVVRAINEGDNGSVWICNEETSTPFTFPASQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1M5</accession>
    <name>A0A084W1M5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011954</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1M5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011954-RA">
        <property type="protein sequence ID" value="ASIC011954-PA"/>
        <property type="gene ID" value="ASIC011954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011954"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8144" checksum="1F2B0428F76D64B3" modified="2014-10-29" version="1">MFTSYARTTARKPRGASYDGSRKCTAGDSTFKVFNKWSVPGRTGHRLGDGFVAQKTRSTQLLVRYPTGLSKGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3H9</accession>
    <name>A0A084W3H9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012690</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01020027">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525292">
        <property type="protein sequence ID" value="KFB44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3H9"/>
    <dbReference type="STRING" id="74873.A0A084W3H9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012690-RA">
        <property type="protein sequence ID" value="ASIC012690-PA"/>
        <property type="gene ID" value="ASIC012690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007864"/>
    <dbReference type="OMA" id="KSNNCKP"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000117">
        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="147"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="743"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="779" mass="85142" checksum="6267D92361972A1A" modified="2014-10-29" version="1">MHPEMFLTQRGKGIMRRSTEDWLQKNTYLPYIVISIRVCLMTYHPFLFLFQRSISPTSSTDIRAMQARIPSHFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGEDTSHKKERKLYNDGYDDENHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAFDHEEHCQVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLFDLLRNTNFRGVSLNLTKKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEADQINRIVEVLGMPPKHILDQAHKTRKFFEKLPSDGSYVLRKTQNQRKYKPPGSRKLHDILGVEEGGPGGRRHGDPGHSVSDYLKFKDLILRMLDYDPKTRVTPYYALQHNFFKRTSDESTNTANTISSLSTSPSVSTQDQPTSHGEYQRGRAQQRQRNHAPPPPSQPPSMAFSSYSSSSSSASCAITSATSSASSYHPSAFLAAKQSHPAPSHQHRRPLPRQEAKPKANHIALPPTTASGKCCRSSASSTSTSSSSSSSSSSSASSLSATASATSTSTTGGSAGGGGGGGHKSYAPASLPLDLGSHMASSLGGLVIPDQHGGAFSTMSGSFLPHNLPLGVTGVVGYAPFSMNDAMLMAAAGAGIGPSVAGGGGNSLGVIGGPVGSTMPPGTGGGVGPPGTTTNDRDESSPMVGVCVQPSPVIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W453</accession>
    <name>A0A084W453_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP006058-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00012934</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W453"/>
    <dbReference type="STRING" id="74873.A0A084W453"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012934-RA">
        <property type="protein sequence ID" value="ASIC012934-PA"/>
        <property type="gene ID" value="ASIC012934"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012934"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014574"/>
    <dbReference type="OMA" id="PMPIYVN"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001863">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF20">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE PIPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012934-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="401" mass="46509" checksum="A30834CF0C399261" modified="2014-10-29" version="1">MSGTCQPRMTLHHLHHQYAELVALIAISCTLFLFLHTQSLTSRLREMEDRLQPPSSLSAASGLSGNSISQVSAGAPNQSNHPHDHLHHHELIGNLHHTYNYLKSTGQMHSLKATELNNTRRAEIPIIFFNRVPKVGSQTFMELLRRLAVRNDYTFHRDVVQRLEVIRLSPERQQELAEMVMDLPVPSVYVKHVCYTNFTRFGLPMPIYVNMVRDPVERIISWYYYVRAPWYYVERKQAFPDLPLPDPRWLKKDFETCVLQGDPECTYSQNAVHEGIGDHRRQTLFFCGHGEECLPFNGVGALERAKYAVESQYAVVGVLEDLNTTLTVLEKYVPRFFSGASSVYFNEVNMLQKINKNSFKPPVSEEIKDLVRRNFTKEIEFYQFCKQRLYKQYLATQLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W471</accession>
    <name>A0A084W471_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00012954</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01020284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W471"/>
    <dbReference type="STRING" id="74873.A0A084W471"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012954-RA">
        <property type="protein sequence ID" value="ASIC012954-PA"/>
        <property type="gene ID" value="ASIC012954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012954"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020774"/>
    <dbReference type="OMA" id="IVAHEGC"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 8" id="KW-0186">Copper</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759950" description="Superoxide dismutase [Cu-Zn]" evidence="9">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="17799" checksum="15E244093D6CDEA1" modified="2014-10-29" version="1">MKVLIILSAVLCGVLAKDQPRKAIAHLDGTMGVTGNVTISQSSCTEPVFIEINVIRLTPGKHGFHIHEKGDLTDGCASTGGHYNPDKVSHGAPNDQVRHVGDLGNIVADEDGNAKTSYSDTVVSLYGARSVIGRAIVIHAEVDDLGKTNHPDSLKTGNAGGRVACGVIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Z6</accession>
    <name>A0A084W4Z6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013233</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4Z6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013233-RA">
        <property type="protein sequence ID" value="ASIC013233-PA"/>
        <property type="gene ID" value="ASIC013233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013233"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6614" checksum="0E8D58A26CACDE1A" modified="2014-10-29" version="1">MNVLVQRHHRSHGNEPKPARNTPEPEAWSATEFQSVIHFPSNPSALGLFFRFTLPKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5R5</accession>
    <name>A0A084W5R5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP008337-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013623</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020688">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5R5"/>
    <dbReference type="STRING" id="74873.A0A084W5R5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013623-RA">
        <property type="protein sequence ID" value="ASIC013623-PA"/>
        <property type="gene ID" value="ASIC013623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013623"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021551"/>
    <dbReference type="OMA" id="VFMVDIF"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="9">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="157"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="382" mass="42033" checksum="4E94B19CEB77D4DA" modified="2014-10-29" version="1">MVFIQNYLLKSAKPIRSFLRSRFLDTLRLTVKGGHGGNGLPKYGGVGGQGGAVYFVAKEDKSLRDVVYKYPNKRVVAGNGEESSKARILGRRGTDRKVEVPVGIRVIDAEKGTIAELDEEGKSFLAAGGGSGGCSGNSFLGKPGQQSTLTLDLKLIADVGLVGFPNAGKSTLVKAISNASPKIASYPFTTIRPQIATIEYEDYRQITIADLPGLIEGAHANFGMGHKFLKHVERTRLLLIIVDVFGFQLSQKHQKRNCLETVYALNKELELYDKTLLDKPCALIINKMDKEGAIEEICKYEKYFHSLKDGLQLCPQELIPEKLLSIDAVIPISAKSMKEIQKVKNEVRAILDLKAEETLQETDHDKESQLRMKLSESGPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7P5</accession>
    <name>A0A084W7P5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Replication initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7P5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014127-RA">
        <property type="protein sequence ID" value="ASIC014127-PA"/>
        <property type="gene ID" value="ASIC014127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014127"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="15888" checksum="73F529747406BB10" modified="2014-10-29" version="1">MVAKSQQSPSNGPNGKQPTVSTPKLGDIQSVKTPDIRASGSPTDCFLSVGKVSEKEINSPCCQSTALACRLNDYRAALRLIHWLHFIQIVLTPISNRLLMIDLANSPELAANRIMNGSVLKMMKVVPTTKIQHHGTTWNPVWART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8C5</accession>
    <name>A0A084W8C5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4297 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021410">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8C5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014454-RA">
        <property type="protein sequence ID" value="ASIC014454-PA"/>
        <property type="gene ID" value="ASIC014454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014454"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008769"/>
    <dbReference type="OrthoDB" id="7742252at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63380" checksum="DD7955A709BE1CA0" modified="2014-10-29" version="1">MATTHSLDELGDRRSSSESRSKQKERKTVGENKAMIGARYGYDFVDLITMAIILKAGSMMKEDELFSCEISKEDATAGKFDDIVFRYTYKGTRTILKIQVKHRTKNQEVSLQELMETSFTESFALIKYFKSFRDQYTPSNEKQIFVLCTNVQLENDAVEWLEKVHPNDVCNVFDPIGATYYRFRKISEVEPRHSNCIANALKKASESYRLADILANHIYGQKELVLYTKNPQRNPLLSKYNNAIVRHMMEYSEARKAIHIKHNFRTNADRNVVNFRKQFEAAYTEIAICSLKKTDQDLAAENFDVYGDIAKKAIKTNDPNKIIERIRNIAENSILEHFPTDIVTDEDVNLFFDKFLIVCDTFSTDDLPSKIAENWRCSNICKPTELVCSLEMEKYMEGLHRMVSKWMRSSPNLPTTLEAKHVEEIIKKVQLHQKYLLLKKASNKYIEDHLTQSLEAKPESLREKPLYKFLAPSDPATNVTKPDIFTFLTPYNSQFSSMIILQTFQLLERDVDQIFFIDINTIEKEKQIILDMCEFFEDPLVMNSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9G1</accession>
    <name>A0A084W9G1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP002292-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014861</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrokinin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9G1"/>
    <dbReference type="STRING" id="74873.A0A084W9G1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014861-RA">
        <property type="protein sequence ID" value="ASIC014861-PA"/>
        <property type="gene ID" value="ASIC014861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014861"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007116"/>
    <dbReference type="OMA" id="KPQPIFY"/>
    <dbReference type="OrthoDB" id="6424205at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001484">
        <property type="entry name" value="Pyrokinin_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00539">
        <property type="entry name" value="PYROKININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784543" evidence="7">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="181" mass="20581" checksum="806DA939D43DC56A" modified="2014-10-29" version="1">MFRFYFFFNLICLYLAIKSALSVEMETNDQKFGHEMTDGATETDGLRREDGEDGINKRAAAMWFGPRLGKRTIPVDLHDELVEEFDSEPLGYAGESPEKLATDLIEGTPYVVVLLTARPRKPQPIFYHTTSPRLGRRDSVGENHQRPPFAPRLGRNLPFSPRLGRSYNGGYPLPLPFQLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R0</accession>
    <name>A0A084W9R0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Up-regulated during skeletal muscle growth protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014968</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9R0"/>
    <dbReference type="STRING" id="74873.A0A084W9R0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014968-RA">
        <property type="protein sequence ID" value="ASIC014968-PA"/>
        <property type="gene ID" value="ASIC014968"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014968"/>
    <dbReference type="OMA" id="GIAKHFN"/>
    <dbReference type="OrthoDB" id="9435504at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038:SF1">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01821">
        <property type="entry name" value="DAPIT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014968-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5370" checksum="E1EF764E5622E470" modified="2014-10-29" version="1">MAGGGDESKLTGLSRYFNGETMRGRANVAKATYASIGLLILYFSLKPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAF8</accession>
    <name>A0A084WAF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transmembrane protein 131-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015225</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015225-RA">
        <property type="protein sequence ID" value="ASIC015225-PA"/>
        <property type="gene ID" value="ASIC015225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015225"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="13123" checksum="1A9E6F920B45D30C" modified="2014-10-29" version="1">MNRTNQRDGLRRQVLSESILFILEQGPGSRQPKRGICGFCGSLRPTAQSRGCGIPVTPEAYRGGRNKQDVRFVTARKLHQHRRGTSLGSIVFRALPELTKVFPKARMSDYFLYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAJ4</accession>
    <name>A0A084WAJ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP010493-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00015329</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAJ4"/>
    <dbReference type="STRING" id="74873.A0A084WAJ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015329-RA">
        <property type="protein sequence ID" value="ASIC015329-PA"/>
        <property type="gene ID" value="ASIC015329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015329"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005466"/>
    <dbReference type="OMA" id="HWLMHAK"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="47727" checksum="D63CFA551834DA27" modified="2014-10-29" version="1">MPDKPAKTEAKKDDVAELETQFIMRMPKEPSAALREAIQSGANNLKDRLFIRLDNDLRYGEVRFDHWLLHAKVVDLPTIIESLKTIDSKNFYKTADICQMMICKEEPDQQSAEEESPNKNKKKDPNKVDKKYLWPHGITPPCKNVRKRRFRKTLKKKYVEAPEIEKEVKRLLRVDNDAVNVKWELITEEEDPNKPSPGSGTDNGAPNKSPSKNTKKSSYNKELGEHDIFGEEVSDSDEEDNPINKNIDIDESSRLSAEADDSRLSDSSSYQGTQQGERNPATEFNKSMFSGAGSSGGYRASRRPDAGASGSKSMSYFQGESSRMDSDNDSSDMPQGGGFGNSQNSNANSATATSVNNNARIYELQRQISDLKAQRNQKEQEIRTIENQTLRQRLQDKLDSLLMEIEDKEKEVRLSAFIKVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB96</accession>
    <name>A0A084WB96_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011492-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00015443</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB96"/>
    <dbReference type="STRING" id="74873.A0A084WB96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015443-RA">
        <property type="protein sequence ID" value="ASIC015443-PA"/>
        <property type="gene ID" value="ASIC015443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015443"/>
    <dbReference type="OMA" id="CEKIGYG"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="558" mass="60901" checksum="E6B5672949771734" modified="2014-10-29" version="1">MAGTGSRTPLANGSTTAHHRYGATTETRTAVVAAVNGNIGEPYDHTVTPAGNGAVPGHTTTVDEEREQLEKRSTLKLCEKIGYGLGHVYNDLCAGVWFSYTLLFMQGALGMPAAEAGAMVMLGQVGDAIATPIVGLLTDRYGTKRQWHIVGTFIVFLTFPMIFSLCPWCSIAPHWWEIVYFTVVILAFQFGWPIVQVTHLAMIPELSRTQKDRSDLTAVRYSVSIVSNVIVYIVTWAVLRANRSTAENQIGPTDAYRFRDISLILTLVGVSMSVLFNFSLTFSGYEHRRNTALQHNIIRPSVSAPVETDIERESLLGSEHRNGGPLPDLDATVMRKPKKNFFKSPLLYQNALLYVFSRLFMTTSLVYMPLWLDERSYQPNGADGQQASDASVEHLATVPLVSFLASFVSSLALKYGNRFVGNSLTYFVGSVISISVCLWIALTPPAGTFSTASLYVIASLFGAGSSITMVSSLCITADMIGKHAEQGGFIYSAVTFADKLITGVVVVIIESVKCRDRTECPEYYRGVLSYGCGLAAILGGLTLATLLCTRASTSRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBN4</accession>
    <name>A0A084WBN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015736</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015736-RA">
        <property type="protein sequence ID" value="ASIC015736-PA"/>
        <property type="gene ID" value="ASIC015736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015736"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="22363" checksum="86C7A057E5E40396" modified="2014-10-29" version="1">MREVATIIASIETVRRDQRIPSVVCAASHCALSLQVSKKSQHELKARGDFSFRTFSRWKMPDRRPKTQVPPVRGITPKWFRLGMESNSVAFCSPGHSMRNKNGREDISLPAARALPSVTPVIATAAGAEETPQDPTRNGGLDERPRGVANQTNPFPARVGGLVRFVSGLVWTTLRAREETEIKNDSDCDIRTCNGWPRLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD03</accession>
    <name>A0A084WD03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016071</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022906">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016071-RA">
        <property type="protein sequence ID" value="ASIC016071-PA"/>
        <property type="gene ID" value="ASIC016071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016071"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5896" checksum="D36041174FBE2E84" modified="2014-10-29" version="1">MALSEDPLSRVQSDGEKPHRPPVVVIQPMQPKQLPSCQIVDRANQPDYSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD79</accession>
    <name>A0A084WD79_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ATP-NAD kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016240</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016240-RA">
        <property type="protein sequence ID" value="ASIC016240-PA"/>
        <property type="gene ID" value="ASIC016240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016240"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016240-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="6862" checksum="ECE50D4B23D8A296" modified="2014-10-29" version="1">MSVLSPSQSIEVANSCLSPSTLPSNSGEPSVPDSMAARPFADGGLPSDRVNFSHRQTHTGGFLCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDA9</accession>
    <name>A0A084WDA9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016287</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01022979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDA9"/>
    <dbReference type="STRING" id="74873.A0A084WDA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016287-RA">
        <property type="protein sequence ID" value="ASIC016287-PA"/>
        <property type="gene ID" value="ASIC016287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016287"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017704"/>
    <dbReference type="OMA" id="NIRTFHK"/>
    <dbReference type="OrthoDB" id="429597at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="8">
        <location>
            <begin position="108"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="717" mass="82572" checksum="22774D52ADD724F9" modified="2014-10-29" version="1">MKSQSHHNSSDDDSDILRRERIIHDVRVQFEKKFQFPSTPSSTLLPRVDTLYRCPPYLVPRLQEQKQKLNAVKSRLNDFEIGEWHQHSRKRSSLLPILNELRYRIRAEFVTQAFAKLYECVSAYELVDVRQDQLHSVHLCEAPGAFVTGLNHYIRLNCHPKTRWKWFACTLNPYHEGNCHGSMIPDDRFIRHTLDSWCFGVDGTGDIMVRENRDDIIARSKQWPEVNLVTADGSIDCLNFPEEQEERVSKLHLAEATLALSILSAGGHFILKMFTLFEHSSVGLLYLLNMCFDELHVFKPCTSKRGNSEVYLIAKHYRKPDGIEQYLDVIYSNLQNSSYTMFDPTTIPEAFLDQMHACASQFVRWQTEVIENNIRYYDANDPCEDERLIIFKETIIDMFFTHYRITPIRATERIVRGKNVTGGTNIYHKESHGTYNERVQSSLTGMRSVEQHQSLRDRLDHVTLTHKELHPRALLDDVPYGFGTHCTLPKELSFAVGKPVERVKNSYYALITHLRLLNDIVDLYRSIAINPDPLPKDKLVPMVQNNVISIDIRLYPSIMNADWHEKQLYHTIVRTTLQLAQRAGETPIAGVPDPRRGVELIVENWLMLTRFSVGLFYLLKMYVFETIEPLSSTRIAFRHLRPDGITNLLALNDAFGSACCSTSALPGTSKSILTLVSPASPLNGDYKYGIINYNNALCLIYCARLLDEMEQHFGTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDY6</accession>
    <name>A0A084WDY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Prophenoloxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00016557</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDY6"/>
    <dbReference type="STRING" id="74873.A0A084WDY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016557-RA">
        <property type="protein sequence ID" value="ASIC016557-PA"/>
        <property type="gene ID" value="ASIC016557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016557"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000328"/>
    <dbReference type="OMA" id="NGHVMLG"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004097">
        <property type="term" value="F:catechol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1520:FF:000001">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF24">
        <property type="entry name" value="GH04080P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="684" mass="79111" checksum="D721E8EF199F74FD" modified="2014-10-29" version="1">MTDNNTLFRGLLQKPYEPTFVPKSDGKLYYDLPDAYLTDQYRPFGASFQSRFGTNAEQRVPFPSVSMPDLSFADVVSRRGHFSVFNAAHRRAASSLIQLFLDQPDPTALSALAAYSRDRLNAPLFQYALAIALIHRNDTRDVEIPSVLELFPDRFVDPAVFPLLREEGNLVDRGNRRAIDIPRNYTASERVEEQRVAYWREDVGLSLHHWHWHLVYPSSGPDRVVRKDRRGELFYHMHQQMIARYNIERFANGLPWTVSFAHLRERIPEAYFPKIIRSSDGRAFSCRYANQLMADVNRTEDQSTVKIADMEVWIRRIFEAIDSGVAQTTNGDRVQLNNKEGIDILGDILEASTLSINFDYYGDYHQNGHVMLGYIHDPDNSYLEGVGVMGDLTTTMRDPLFYRWHQHIDDIFVRHKQRLPAYTASDLAFADITVDSFDVQLNRPNAPKNTLLTFWQRSQFDLGTGLDFVPEGNLFVTFTHIQHAPFSYRFQVTNRSDRTKRGTARLFLGPKVNERRQTLPFKDQRRHMVELDKFMLDLRPGANSIVRRSDQSNLTIPYERTFRNIAASSQPGTEVFQFCNCGWPNHMLLPKGSPDGLEYDFFVLISDYNQDRVEEFNENDTCNDAHMFCGLRDRRFPDARSMGYPFDRFTPSSVKSLQEFARPYGNMKTTPVTIRFTNTVIART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE58</accession>
    <name>A0A084WE58_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00016655</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE58"/>
    <dbReference type="STRING" id="74873.A0A084WE58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016655-RA">
        <property type="protein sequence ID" value="ASIC016655-PA"/>
        <property type="gene ID" value="ASIC016655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016655"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010264"/>
    <dbReference type="OMA" id="DSAKKWM"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="235"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB48502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016655-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="326" mass="35026" checksum="5A1CD8A38D3BDE8D" modified="2014-10-29" version="1">MDRLGMSPLVAAPAAGQFRNPFGRRPWMEQSGAAAAAPGAKGLKGIVAGGITGGIEICITFPTEYVKTQLQLDEKGATKQYNGIMDCVKKTVKTNGVLGLYRGLSVLLYGSIPKSAVRFGAFESLKGRLMEPNGQLSTSGKLLAGLGAGVAEAILAVTPMETVKVKFINDQRSATPKFKGFFHGVGMIVRQEGLSGVYKGLTATIMKQGSNQAIRFYVMESLKDVYKGGDQSKPVPKMVVGAFGAVAGAASVFGNTPIDVVKTRMQGLEAAKYKNTMDCAMQIWRNEGPAAFYKGTVPRLSRVCLDVAITFMIYDSFMDLFNKFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEV8</accession>
    <name>A0A084WEV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP012916-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016758</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016758-RA">
        <property type="protein sequence ID" value="ASIC016758-PA"/>
        <property type="gene ID" value="ASIC016758"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016758"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016758-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="30255" checksum="9560BC26AD1FFE4D" modified="2014-10-29" version="1">MDFEWTSMVTEGNISSVMEAIIHTVVSFRREVVENLKLAPEQHTDQWEKMILFIEDTTEEHEKEMSDKMQSQVKQLNDRMEMIKYERKRHSWHAEDLKPVRSSDRLKRYKRRSCFVSTITNDTFCIDACGNVRHPFLVHCEVRYTIGEGWVVLRGKFDEPDKLYQDWTPMDNESGADEEETCEVASRSGQHELLVQFILKIERESENYHISVGKHSEISATPVGEAKPAKLEESTESPFDCTRVQRKVWWYNDCQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF48</accession>
    <name>A0A084WF48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101302005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017098</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017098-RA">
        <property type="protein sequence ID" value="ASIC017098-PA"/>
        <property type="gene ID" value="ASIC017098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017098"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14858" checksum="EDF0A55D2F4AAB40" modified="2014-10-29" version="1">MQTPSEIGDSCRRHCLAANAFRRVACMHACSHACVQLPIRAAFRVHSARADAEFRPSIFNIKKRRHRNPGIRDRLAQRSAEKYRFSPWSQASPLLGCALSLRSHRFGQNHHPPARASGEEGPTERGGRIFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFJ5</accession>
    <name>A0A084WFJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016994</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016994-RA">
        <property type="protein sequence ID" value="ASIC016994-PA"/>
        <property type="gene ID" value="ASIC016994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016994"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16929" checksum="28B9EBB4C2B48557" modified="2014-10-29" version="1">MIHSPLAESPSRSALYVARIRTQWGAFAVDAHSHGKGTWLLNRTCTVGPWTPIGRALLPCWREPFESISQGPTPLWPCLLQAQAKRPWLAGRSNTNTVATRCGILILFRSLTTAKAARCSEDVRILRCPGDVYLTSSKREKMPSSWFFSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGB5</accession>
    <name>A0A084WGB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017369</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017369-RA">
        <property type="protein sequence ID" value="ASIC017369-PA"/>
        <property type="gene ID" value="ASIC017369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017369"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004334"/>
    <dbReference type="OMA" id="QDICVRP"/>
    <dbReference type="OrthoDB" id="8032897at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="12065" checksum="A6C07A46E5BE77DD" modified="2014-10-29" version="1">MQDICVRPNSNSKSPFVYFHQDMPEINPNELRKLYTNYNSYVSNQLDNYGLDPLQLQLLAQYAQTNAISGGGGGWDQLYRAPEMKRQIRYRQCYFNPISCFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGQ1</accession>
    <name>A0A084WGQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017495</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KFB49395.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017495-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14863" checksum="3D7D987305072912" modified="2014-10-29" version="1">MLCGSDPELDAGFRKGKLEPGTSWRAQMMMMVMKINVSRIARQHHLREGVRMYAGVGFGSTRSQAESPSVDQNRSRLRSFAFALAQFEADEAQSRASTRSRPLIARSQPLVDQPGRSKGLILGHTSTKSRSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHD7</accession>
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    </protein>
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        <name evidence="2" type="ORF">ZHAS_00017648</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023807">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHD7"/>
    <dbReference type="STRING" id="74873.A0A084WHD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017648-RA">
        <property type="protein sequence ID" value="ASIC017648-PA"/>
        <property type="gene ID" value="ASIC017648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017648"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011058"/>
    <dbReference type="OMA" id="CQFNHVT"/>
    <dbReference type="OrthoDB" id="10021476at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
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        </location>
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        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
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            <begin position="14"/>
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        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="362" mass="41133" checksum="1ED69C0D1A24382A" modified="2014-10-29" version="1">MAHLQRHRLESVSDHSGPTSSSSKSDSSDGSASEICEVMQEWSLDGSDAQSHPLQLHHLQQQQLQRQQQQQQHHHHHHHHHHLHHQHRTTQQQHHHSAAAAHLLATHEHLHVRPQHQQQHQQQQQHLAGLIPSPNSSYTQEDDVDEQDVDELEYSKHDLISLDNGVITDYERAQIESFFSGLGTEVYVSSSLANLYERVGKEDWRLVFTGIPVLLHDKGSTRSRCTPRVTFVLAERGTCFALWKDTIDNLSDYKVAAAAFHTMCLSADHRKVIGFSFDSNQAAREMWVRVEELTSNPENIALSAPGRKRKTPKRAKPIVLPPKSQISQPCQFNHVTSVTTGDTQRYFSLQAFVSAPVKHRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHZ8</accession>
    <name>A0A084WHZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017864</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017864-RA">
        <property type="protein sequence ID" value="ASIC017864-PA"/>
        <property type="gene ID" value="ASIC017864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017864"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="516"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
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        </location>
    </feature>
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        </location>
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            <begin position="443"/>
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        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="566" mass="58918" checksum="1F8BD71703818236" modified="2014-10-29" version="1">MAAAAAAAAAAAASTNSTTSQASANHPSRLPPSSPAAGSTSSTSSGVSSDYSSSPSSTAVLTCNNNTPSRKGSPPTVAPGGSYSFYSPSGAQQHQVGGQIAYPSVITRAQQPQQSQQQQQLAHNQGHSWDTSTDTVRSDPMVMVKSLQRPTVDECSEQTKPPTKATEGGSKSRRKKQTDPKASKLNGITHQRVENDRMVDPVPIKTELDSGGTAATAAVTAAADLMMQRWNYGTANGLVVGNSAGSRIPFSSSPSSSSSFFPSPSHSHLYYHHGPFHQDGAGSSTGSSSLVPLAPSEMLAGTAPLAAESSPSYTTLLNVPSAASRSEDERSRWSSSAPTSHDKVVVPNIEEELGFLSEHNGSGSKAAVGQQQQQVAGGADGTNNNNGTVTVANTLKKLNIPANMNKGFMGSYLKFLQGEREGSPPPVNRPGRKTAWSRPPPTTSSNAVKNTTTATTSAATGGTNASSPKGGGTQQYNNSATPTADGGDQRLKQQQREVRNGTDGMQGDGGSAATITPITPLANRRIRIGKESIILRRTLATLAKVRMQPHYSRWTFPPPPEVVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJF6</accession>
    <name>A0A084WJF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018621</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024023">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018621-RA">
        <property type="protein sequence ID" value="ASIC018621-PA"/>
        <property type="gene ID" value="ASIC018621"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018621"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018621-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8454" checksum="730107C3A0DEE6F6" modified="2014-10-29" version="1">MFWSLVSWSAVRASGRVHSWPRYGAISMWKAISSDSEAEWNETDQPKDTRNEWRCGNYADAWERKRNACGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJJ0</accession>
    <name>A0A084WJJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005735-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024036">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB50384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084WJJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018408-RA">
        <property type="protein sequence ID" value="ASIC018408-PA"/>
        <property type="gene ID" value="ASIC018408"/>
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    <dbReference type="OMA" id="MVSIHGV"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="CCCH ZINGC FINGER"/>
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        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
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            <begin position="439"/>
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            <begin position="466"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="675" mass="74629" checksum="26343AE49F3B96F7" modified="2014-10-29" version="1">MGQPSKIFINPKFAKAHINPMFLASHGSLMRVDADHQVQNPPQQAAIHVNPAFLQKLRSQQVTTATTVAATVTSAAPAAMVTSANAYRMLESRPSEPAGKPPPFSGAVNPIIKNTRRKLIRATTASGAKVTAMHNPNDAKRTVIGTANSQLAPLVKIGKNKLIRSSVPATTGMENVKPKVLPERKSLRIDRRIPPRSPMEKPSFVKRYALSRINGINPKKVVITDRKLLKLKRNIMPVKKVEKAIANKSTVAYASKNKRLVLVNINGVLYRSSNNKLQKSLPAVSKSAPASSYNHPAKTKEHFLIIRGTRFALDRTGMKLRTIRDAAAALHAPEPRMNRIDIGGLTYKARKDGTFIRTDNHRTRSHLSTAKQRSIQVLASKLKKCNEPCHIYRRLGKCLAHNRGKCPKLHDPKHVSICQKFLRGECILDGCLLSHNVSLEKMPVCTFFLEGRCMRDVCPYLHKKVSEKERICDAFLNGFCALADKCPNRHIFQCPEFERNGKCDRIKCPYPHGRKEMKKKPAAGSNSPVTVETTAHPETIALPALPVRYYQDDGTSRTSSKVNQPEKSGELSASERMQLKRMLGEVDKMKQRHAHEEVDQLQPAGSGIQDDGESVSIEGEPDDDDGGDRKTAGGWPADDAVPEDENAGGSDEEEDTRPPVLRRKALGTLPSFIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJP2</accession>
    <name>A0A084WJP2_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00018466</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018466-RA">
        <property type="protein sequence ID" value="ASIC018466-PA"/>
        <property type="gene ID" value="ASIC018466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018466"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5326" checksum="4EB5B3AE215F8E6C" modified="2014-10-29" version="1">MPRASNGEGKCVPRCAGENGTVHGLVLAGSLVDSAVLVTIWYASQQQQGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKK3</accession>
    <name>A0A084WKK3_ANOSI</name>
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        <submittedName>
            <fullName evidence="4">AGAP005546-PA-like protein</fullName>
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        <submittedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM135 family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB50747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WKK3"/>
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        <property type="protein sequence ID" value="ASIC018794-PA"/>
        <property type="gene ID" value="ASIC018794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018794"/>
    <dbReference type="OMA" id="TIHACLV"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Protein FAM135A isoform a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022122">
        <property type="entry name" value="DUF3657"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12394">
        <property type="entry name" value="DUF3657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1700"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1140"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1203"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1264"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="880"/>
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        </location>
    </feature>
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        <location>
            <begin position="922"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="956"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1293"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1583"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1611"/>
            <end position="1624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1969" mass="212738" checksum="E644902B1FC79349" modified="2014-10-29" version="1">MGSDGRIKLVELYQVRCSLRVSPRLPVQVETCLPDAATTGIPSVQSVLTSAAGTGSGSLPSSNTGSVGGGVGLVAIGTNSAGNGAPLNTGPGGRPEVGPPSVGSSGVGGGGSLSSMPSSSMPTPNSAATSSSVSGTPGPPSNGMGGGERGGRMSAGGGEGSSGNSPTTSSDSRSGATIIDDAGASRVFQILYRNEEVSLRDVIMFRAHLLVDSRHLKESIERAEFSLNLELWFGEQTNGNILTLASTRTLQLNFHPGRGLHYHLPVLFDYFHLAAVSIGIHASLVALHQPYINAPKSTKPWMSSSKLNCRGGNSPGPLEAIFFGPQVGGGAKCGGGSAGRLLHARNVHKEICALLLGALESLRLSLQEFCTVLPHQWSALTGSTPLSNLDTEQRLKKLSDSAKLLDTEDDLAARANSDIAQLCAECILYWRRVLSAATQPAVHGLLAKKHHTLRVRRFAEGFFVIDNPRHLASGCYDSNYQNYVSICEMARRSRYLSSLPPLPVHCTPLDGDANSLPLIFEDRYTDTNEYGKRRSGSEPHLNGTHTVVSAAASVGGSTGTGTLGKATKAHHHPNKIAPILAGGSKECSCGIATCYIEPVPKICGSYMGIMTPRYALGGDILQASLTITPAAAASQNGLCPKALSRHSASTLLDPPLPVAIELQCPWDQQFKGIYTTGPSVFSGGTLPTRHSKSLDQLELQSSANSASLPRQHLHNAPYNGYGHQQGPSHPQQQHQQPQQQPQQQQQQQQQQQQQQPQQQQQVPRQQPLLYQQHQGQGQQLQQQQLPAGVALLQTLPKSKPKNPVQAEDLLKNINEFREKYKNPGDPRKVIHAGGTATHNPTYDLQQDAFSVGLLNGYAKLASDFRHELKQVHSSGSHRNGTQQYHNSQQQQQQQHVGQHRDQGHRTSSGSAGAYYNSLPKGAGMGVQGGGPIAPRSSFPPVRSKKQQQQQSSSTSLPTKAASNTIPRSNSSQQLRLAQNGSTPSAMSMGGVNSATLPHRSVEFARIRVSDFRQMVHGQQQQQQQQQQQQQHRRSTSNGGSTHKVGVTANGTAGAGGGAGSSSSSDSPEITPRTRNKQRRLLSSASVPFQLENLELEPVGGIGPAGIPAVSGAGGFSESLPNLAPPPAAFASDSLPPSGATFRLRRCHSSSESTSSLSEQSGWVSSRRSTGPSSPDTLRNDQRVVNGEQLRKKLLKLLNEQPRLVAGRKNSTPTSQTEFFARSNQSSMKSKPTFGAGANGSDMIRGASVQTENWNNLEKDWNESRNRAATAAANAASSGPYGMVSGKRAPGDRSTGNGTTQPKLNHAGGFSTTDIRPPRRSNKKEKSKSDFDLAHISDYVFDDLRLLPPQQFRDAPPPPDEFRDPPSFIEDVSKGSSKVEQPTTAKSSTVTPRTIPLPEPPRPQQQQSVVKEESPAQQHQKLQHQQQQQQRQSVQYYATLPKSHPPVTPAPLSVVFQPQIITAPQQQHYATPQSLTQSHSHHYSKPHNAPVNMGAAVKKCEVQAIDNPLYHIYEVVKTPRPVMKSQSSNELAAIAKCAETLNNANATMVSLGGIHHQPVTAGPQQQQHNGNTHYAPLPPPVAPSMPSTTTMTSTTTPGPPAGSTVERKASVREQSSAAESTMTTRRSSRANETDEPTAEENPEHEKRVDPPMQLLEFEKCREEFRKQINYSGSIYSDFQKMASEMPYFHIADEFRAFSPAGLHLVICVHGLDGNSADLRLVRTYLELGLPGAHLEFLMSERNQGDTFSDFDTMTDRLVAEVLYHIETYQLNPSRISFVAHSLGTIIVRSALARPQMRPLLSRLHTFLSLSGPHLGTLYNSSGLVNMGMWFMQKWKKSGSLLQLCLRDAGDPRQSFLYRLSQRSTLHHFKNVLLCGSSQDRYVPPHSARLELCKSAVRDQSNLGIVYREMVHNIIAPMLARQDLTLARFDVHHALPHTANALIGRAAHIAVLDSELFIEKFLLVAGLKYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKN4</accession>
    <name>A0A084WKN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19">Zinc finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00018828</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKN4"/>
    <dbReference type="STRING" id="74873.A0A084WKN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018828-RA">
        <property type="protein sequence ID" value="ASIC018828-PA"/>
        <property type="gene ID" value="ASIC018828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014377"/>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF128">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="415" mass="45692" checksum="ED7F5CA8364BF97A" modified="2014-10-29" version="1">MCKFCTSAIVTFYQLRRRLECVRRFNVGLVKLIEGNPIDLIELFTTEGNYLVPLLKNLGICARNSDSVTVESLIDDLSSFKLIDGSQKAEYTVMDAAPAEPPVQEFQLPAAYALSVNGIILNNVKVVCTNNTNQVQAIVPVANATDSPIHIISDSSDDEAEKSKDATVETVSNGNVTAVAAQPTQSSGSPVRPQPNPGPPPNLGPPPNPGPPPNPGPPPGAYPCKPCSLTFNTLIDLRNHCEAANCGGTHSCTICTILFDNKDSLKTHMEIVHHTQTYFYCDICVQIFEDATELANHKTLHMHPAAGRCGRCLATFGNGADMKNHVCITYRHDFMCCGVDFEDHINYTDHMKSNHNTIVNVRPKIPHGMLYSKFQAKLRSERFFCGFCDKKFRTNADYQNHLGSREHFIHAMVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKP8</accession>
    <name>A0A084WKP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006923-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018843</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKP8"/>
    <dbReference type="STRING" id="74873.A0A084WKP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018843-RA">
        <property type="protein sequence ID" value="ASIC018843-PA"/>
        <property type="gene ID" value="ASIC018843"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018843"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018843-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="38430" checksum="584FB7A5E4789441" modified="2014-10-29" version="1">MDKMSTVPLIGAVSRGVTDVKFSRPLPSSSFTIENLIAVKRRRSVASDSSDQPQFTGDRETSLSPVIDPVERGVDSPQPFPSGGSLSLTEASTPQQQHQQQYLAAAAAAAAAAAGYSAAMLSFGSFPPLYHPWAPAGRYLSQAANEKLSSFLFHHSNGANHKLHSSESSSFPSIDSQPSPAVPPVPPPSHGMPSPSSAGDGRVSPRARSGDKFHLQANDAGLLSKVYAAAAYQHQHHQQPRYLGASSPGVPFPGSLEPNLPHPPLAHIAQHRMLPDEAPYGTPFDGSRGGGSDSTPTAGPPGGPLVEGGDGADEDGGDSADGSAYSDDISLSLSPAGCGKSAGKFAKVPTINDSRSSTTLQDSPVVEWTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL72</accession>
    <name>A0A084WL72_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019008</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL72"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019008-RA">
        <property type="protein sequence ID" value="ASIC019008-PA"/>
        <property type="gene ID" value="ASIC019008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019008"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019008-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9732" checksum="5C42DAA20F16CF7C" modified="2014-10-29" version="1">MSNVDRKHDAPSSTKKTKCLICLANTFRVPLCPKAQDRRRSETGKIRPPEGTNHRTPHDQPGNLVGDFVMQRSSSSVWRIYLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMT1</accession>
    <name>A0A084WMT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP006825-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00019586</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WMT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019586-RA">
        <property type="protein sequence ID" value="ASIC019586-PA"/>
        <property type="gene ID" value="ASIC019586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019586"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001883"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018716"/>
    <dbReference type="OMA" id="YAIAYIC"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="12">
        <location>
            <begin position="159"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="13">
        <location>
            <begin position="484"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="896"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM tetramerisation" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1478"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1541"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1691"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1825"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1930"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1966"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1488"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1541"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1717"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1844"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1898"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB51525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1986" mass="223047" checksum="D6AA4D3709C841DF" modified="2014-10-29" version="1">MKKNAFNYETRDVGALLPVLREKLRNLQSSETGATPPLSPSPPPPSLYFESSSISSRSSIVEPFDLNVASLYQVFHVKRTARSWIEANFQKRECIKFIPSTKNGDSCCCGQERRTHQFVPGIEPGIAGDVWTPQKHTRAQSTDAYGTIEFQGGAHPTKAQYVRLSYDTRPELLVQLFTREWNLELPKLLITVQGGKANFELQPKLKKVLRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRSGRVVSIGIAPWGIVERNHELLGHNRDVPCHSISSPRSKLAVLNNRHAYFLLVDNGSQGRYGAELILRRKLEKYISNQKLQPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDNPPVPVVVCDGSGRAADLIAFVHKYASDSGEQQVLESMHDYLLATIQKTFEVNQDQAEQLYQELLQCTKNKNLITVFRIQDRPEGNTQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPHGALDEAMMQALEHDRIDFVKLLLENGVSMRKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYVYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYVNTHRKPSTFQRSAGINSMSLVAGLLPVTSDMALFELPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVACKLYKAMAHEAADDDLDTEIYEELRSYAKEFESKGLKLLDFCYRQDAERAQRLLTCELQSWSSQSCLSLAVAANHRAILAHPCSQIILADLWMGGLRTRKNTNLKVICGLLCPFYIRKLDFKSKEELQQMPQTEEEHLENQYLDYEDRDKKDPDAEALLSDTYSMKDTKVQENGKVSLTDSENTQYKDYLFDSDVRQQRPLKLKKKIYEFYTAPITKFWADSMAYVFFLVMFTYTVLVRMEETPSWQEMYAIAYITTLGCEKIREIVSSEPVAISHKFSVWAWNMWNPCDAAAIIFFLIGLALRLRPYTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLLVVLMSFGVSRQAILFPNNDASWRLVREVYYQPYFMLYGEVFADDIDPPCGEDPSQPPCVTGHWVTPIAMSMYLLIANILLINLLIAVFNNIFIEVNAVSHQVWMFQRFTVVMEYQQKPVLPPPLIALSHCYSLLRYAIRKAKGLQESRDNGLKLFLEKEDMERLYDYEEECVEGYFREQEILLQQSTEERIKNTDERVDHMAQKIEDINQKENIQSAAVQNIEFRLRKVEETAGEILSHLAVIHRFMAAHTLMQGGTMQGSTGNVSGNVALEGAPGIAPIPADHRTRTISESDSYIMQPTLPPPTQRRKFNRSLTEVRPDAYIFDEGRHLEVRTVLEENEGERSPDQTSQPFKRDRKLSIRSEDSELFPGSGVQKTLSPVDSLGAAIKPSPPPPPPFLNIRQDTASTESKDTLTPLEGADDRTLVGDETVDDLMDGNYEGLRQRTGRRRNSSMCGPGVGISMGGSFGGGTPGTGVGGRRNSESASGGGLDINKSQTSLCQVAGLGFTKRQQSVTQSEPDSGNDQPIQRPVPKGRHLLLQIHTEYTSITDELESVCHMIASPTSSLREAPKKKSVNELSNPEFAAMIEKRHLKECEDSDYMMMETLFQTRCSLEDSDEYFDDAGPETEHGPRKMLRRETAIELPVTPSKSNIVSLADSAQGPEDYAGMKNERQGASNRNSLRDSKNSPLSMSSQNSPRNSQYMQGAFLNPSVFEGASRLYKKSCESLQKNSSTDTEYSLQPYRFIKQSSNETNSSFNIDNSSITNDLSIDGETSLNSTVIEMVSSATIAVPPPAVDDRTGFLPKRTSSIGSCTTQHTQQQQQQHSVESRPTFLKKQFSIEKSTPGGSPVAKDNGGSIPEGLERLTPTPAPAIPSKPPRSTRFSDSLSVLGTKSVLSLLKESSSTSTEEPMHEGRNAATIPCISTNLVQDEIAKLSSNIKSSTDEDTDPPINETMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMU0</accession>
    <name>A0A084WMU0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001208-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC019597"/>
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</entry>
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    <accession>A0A084WMZ8</accession>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
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                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
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                <person name="Shen B."/>
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            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB51592.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019663-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="31413" checksum="0753F67D3BF98E44" modified="2014-10-29" version="1">MNDAMMIKCEPIIEDVELFNTLVADGETQRRDELRMLCLYKLKVAEETVSLLEAQGIDMECLRKMRIEDVDELFDGKPLGAKILFREAFLEWRDEIGLPCKSIKSVSSRKRPSEPTDGAQPVPPKRQVASPHWNNCLPPQSVIMEKEPVTQCSKQNVSYQSFRWPMTPSTLKEILDCNSLGRSIMAMGCLGGLGKSLQYQLTAIIIDYHMEFETKITTPQLENYAYCIATLFPHENPLTYHIPRGPNRRNPGGSLYSRFINQKISKKALAIGNSVAAS</sequence>
</entry>
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    <accession>A0A084WN97</accession>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KFB51691.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019777-PA"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="94" mass="10266" checksum="32B83A9314633EA3" modified="2014-10-29" version="1">MELNGNRCPAVWGVGEANLVQIPALIPVPNVAHPILCPSSRQTGIGGNNLGCRRGQQWLPFAGGTCTTCLLDIHHGRSHPNQRQQRRRSARVHD</sequence>
</entry>
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    <accession>A0A084WNC1</accession>
    <name>A0A084WNC1_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP007500-PA-like protein</fullName>
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        <name evidence="3" type="ORF">ZHAS_00019804</name>
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    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB51715.1"/>
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        <property type="protein sequence ID" value="ASIC019804-PA"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785027" evidence="1">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019804-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="221" mass="24452" checksum="CAF1297BEE57CFD4" modified="2014-10-29" version="1">MWNNNLSLLLGVALVIAFVGSVRGQRTPTISYITQEQIKDIGGTVELECSVLYATEYSVHWIKTSNDRSDVVFLSTGSSLVLKDSRFSLRYDLSSSSYTLQIKDIQETDAGIYQCQVVLSVTNKITAEVPLNVRRPPIISDNSTQSLVVSEGQPAQMECYASGYPVPQITWRRENNAILPTALRDGGDSPDTIDRLLIFLFPERIHGPAAKVAPEDLLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNP8</accession>
    <name>A0A084WNP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">HpcH/HpaI aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019999</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024644">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019999-RA">
        <property type="protein sequence ID" value="ASIC019999-PA"/>
        <property type="gene ID" value="ASIC019999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019999"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11568" checksum="0A131A869AB159F4" modified="2014-10-29" version="1">MAHYCAHPALKSTPFLPGSVQLFRSGGDRFPVFHVTSFPSPSTLKDSSMEFICTICLARDANSLPQFDSMTNGIDCAMIGERNNPFKGNDSEGIFGTISSDHKYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP22</accession>
    <name>A0A084WP22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020135</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525361">
        <property type="protein sequence ID" value="KFB51966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020135-RA">
        <property type="protein sequence ID" value="ASIC020135-PA"/>
        <property type="gene ID" value="ASIC020135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020135"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11591" checksum="64BE6335799984B1" modified="2014-10-29" version="1">MHRRAIAFHLMPCFNTTPLRVCAFYLHEASHEQGTASFPALATPKTRADAQRHVVWHTACSFRCAVHAAHAACRVLSLPTLARILSHRQPGGTILPPPDAVVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP68</accession>
    <name>A0A084WP68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024945">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525365">
        <property type="protein sequence ID" value="KFB52012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP68"/>
    <dbReference type="STRING" id="74873.A0A084WP68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020202-RA">
        <property type="protein sequence ID" value="ASIC020202-PA"/>
        <property type="gene ID" value="ASIC020202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020202"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008004"/>
    <dbReference type="OrthoDB" id="7738517at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="226" mass="25523" checksum="B42ED4111EB65FE9" modified="2014-10-29" version="1">MDNSLNPSELLLLVDEAIGIPDGIINCVELNRLLKMLAEDVTNGRQESENQRLIQEDRLKALEEALAEVNEAMDQFEDLQPNVQEGAAETRRDDEKSKEVESGLEETEDVAEDQYNDEQMKVVESTSDDKQEVTEKEQVNEVLEESVGTRVCQLRFIAATIRVEVRPVHLKCTRGAPGDHTLVPVNRDLLRLLGCCRADRDQCDRGTVKNGTLYELNCQRLTVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPQ1</accession>
    <name>A0A084WPQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00020302</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPQ1"/>
    <dbReference type="STRING" id="74873.A0A084WPQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020302-RA">
        <property type="protein sequence ID" value="ASIC020302-PA"/>
        <property type="gene ID" value="ASIC020302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020302"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017832"/>
    <dbReference type="OMA" id="RCSCFVR"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000020">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785294" evidence="13">
        <location>
            <begin position="23"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="591"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB52195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="815" mass="92888" checksum="2F707AC8B788B25A" modified="2014-10-29" version="1">MGVGVWQVCLPLLALLASLAQGSVTCPKECSKCTGTKVECPNFTLTLKDKHLDVRCNWRYDIYGSAYIKAYYFSDMAANSIKGLPFYDQLTFAKCAIPENRSLSDTLSMLGPLTNMKKLFFVENVDSAPLESVLFEGLDSLEILSLKNVTQHPIEASDLFKNIPHLKWLDLRQYDGDSLPADLLRPLQALKTLEYQQNAYIKELPPGWLSNLPQLDNCVIYGNGLTRLERFVGLPKLKKLSMRSNQLEELPEDLFSELPQLIELDMQRNHLTSLPDKLFGELTQLEMLDLSHNKLPLIPDTLLQNQSQLRSLNLGYNQLTSLNGFMPNLQTVDLSHNAIESLQFKQVLKWTKVSEVSLSALECDYIERDCPAECACQIRPEDGVLTVDCSARNLTTVPMLHIPQDNKYRAFELRLEDNLLETLPDKAVMSAWEMVHRLNVSNNRLDSLEVNNLPIQLQMLDVSGNRLRAFGEGVAQQLKHLQNVHLKANPWECTCGAEVLNFVQANSTRITDFEAMRCEDGETITMNLQNELCDNQWKVVAAICGIVAVFLAIAVVLVSFCYRYQHEVKVWLFTHNWLQWLTSEEELDKDKVYDAFVSYSHKDEEFITDFLVPKLESAPMNFRVCWHVRDFMPGEMISTQITKAVENSRRTIIVLSANYLESVWGQMEFKTAYLQSIEDKRNRVIAIIYDDIGNVEDLDQELRAYLRTNTYLRWGDPWFWDKLRYAMPHPKRVKGMQINNNMRHHIATIDKLELIKTLQNGRAPAGDGDASPAQESTPPIEHVVKEIDGPLAKLYAPPAPVFTISTAKLDLHAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQD1</accession>
    <name>A0A084WQD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020670</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525392">
        <property type="protein sequence ID" value="KFB52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020670-RA">
        <property type="protein sequence ID" value="ASIC020670-PA"/>
        <property type="gene ID" value="ASIC020670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020670"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020670-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="12472" checksum="BE20A8E74331F3D5" modified="2014-10-29" version="1">MKPDAIPQDLRPERGSVCVRVCKPFYQADICSFNRKPFIPGRVSLSMADCIGSGAGDLEPALEASPQGECVGEEKHMGKKPGSKLTGTREAAGKTGLKPGRILDGIGRRGFLLFALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQI2</accession>
    <name>A0A084WQI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Myosin d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020718</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020718-RA">
        <property type="protein sequence ID" value="ASIC020718-PA"/>
        <property type="gene ID" value="ASIC020718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020718"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9259" checksum="092F1D66405302C1" modified="2014-10-29" version="1">MNNSGNNNTKSGCKDQPPSVPSVLGQSFSPGAPGEEENAGVSVLGNKTSASNPGSPAGEENLILLIHMIWSVFAWDFEFEGLFAIGAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR19</accession>
    <name>A0A084WR19_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020917</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR19"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020917-RA">
        <property type="protein sequence ID" value="ASIC020917-PA"/>
        <property type="gene ID" value="ASIC020917"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020917"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020917-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="5461" checksum="1F750DB2D5AC2A80" modified="2014-10-29" version="1">MLGTDVHHGRLFNLALGFQCQLERDLCLAGTGITSQLKDAPHRNAAASQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRF2</accession>
    <name>A0A084WRF2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021063</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB52796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021063-RA">
        <property type="protein sequence ID" value="ASIC021063-PA"/>
        <property type="gene ID" value="ASIC021063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785351" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11743" checksum="3F291CFF575CF997" modified="2014-10-29" version="1">MITVACSKVVVVVLLLLLESSCSLVHVLARLSSGGGRKTANRVGGEEPGPRPIVKQTDREFLKALIFGFGRAVKCRRLRSFPSHILDPRCARLPPGMADPSGSFLVCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRK3</accession>
    <name>A0A084WRK3_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021119</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021119-RA">
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        <property type="gene ID" value="ASIC021119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021119"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021119-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8460" checksum="402B680722ABE22F" modified="2014-10-29" version="1">MDFDRFTLPSVGFFIDRRSFALIQRAGKRPTRRGPLPHRAGCLKGLAGSGRALAERRKVMNRSRYQSVAQTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSP9</accession>
    <name>A0A084WSP9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021543</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSP9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021543-RA">
        <property type="protein sequence ID" value="ASIC021543-PA"/>
        <property type="gene ID" value="ASIC021543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021543"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10388" checksum="35642BE8C489D87D" modified="2014-10-29" version="1">MVMVTCFGVNYIYRGKALFRNEAVDMEQHTNNHCHQDDIKKNVLPFAVPSLDGVQLIASDAGANQSDKFTDGKHVAICVFKHITFDMEQMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT24</accession>
    <name>A0A084WT24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP012987-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT24"/>
    <dbReference type="STRING" id="74873.A0A084WT24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021680-RA">
        <property type="protein sequence ID" value="ASIC021680-PA"/>
        <property type="gene ID" value="ASIC021680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021680"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017737"/>
    <dbReference type="OMA" id="YPSPNYQ"/>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF9">
        <property type="entry name" value="GLUCOSE TRANSPORTER 4 ENHANCER FACTOR, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="327" mass="34987" checksum="66F506DF86F8B141" modified="2014-10-29" version="1">MASGQVLMAARSCVARRTQVFKPKVRHASQRIFKCTWKGCGLNYSTCAEITSHVRNAHLGPRKPNEYSDEEDFFFTETEDESDESAPNPPSPPTLSHRDMARPPHEDPEYQRQIPPLPAGLTVAALSSNGTSSSASSSSSSSNGTGSSNGSTNGTSNGAVNPHSSVSPLIHHNYTWSQVSPTSPQKHVRLSPRPSASYPYPSPNYQHHFQAQAAQQQQQHHQQQLGHIQLSPGSGSATGTSGTAAYHQLLAGAAAASAGAVSLGSYSTSSSSSAGSVGSGGQHRSPVSPNRRTRGENKKCRKVYGMDHKDQWCTQCKWKKACSRFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTE8</accession>
    <name>A0A084WTE8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent calcium channel type A subunit alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ZHAS_00021718</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 20">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WTE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021718-RA">
        <property type="protein sequence ID" value="ASIC021718-PA"/>
        <property type="gene ID" value="ASIC021718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021718"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008573"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014673"/>
    <dbReference type="OMA" id="HTTCYDE"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000043">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 20" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1004"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1074"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1206"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1295"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="1335"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="684"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1501"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1592"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1696"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="1738"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1501"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1596"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1703"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KFB53492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1813" mass="208466" checksum="D681E87682EBD256" modified="2014-10-29" version="1">MINYIVCIYNECLIDCSYLCFNRLAASQEEALPDKDGSGEEMGPKKGKKGSPRHRTGPPPPGPSSLFIFAEDNFIRKTTKFIIEWPPFEYAVLLTIIANCVVLALEEHLPRGDKTVLAQKLELTESYFLCIFTIEAALKIVALGLVLHADSYLRNIWNMMDFFVVFTGLVTLLPLPLDVDLRTLRSILEIVEEGDMPTPCYEDKDVVNLDRPVGVHLCNSNESACIEQWEGPNYGITNFDNIGFAMLTVFQCITMEGWTSTMYWTNDAIGSTFNWIYFVPLIIIGSFFMLNLVLGVLSGEFAREREKVENRQEFLKLRRQQQLEKELNGFVEWICKAEEIILAEDRTTEEERMYIMEARKKAAAKRKKLKTLGKSKSSETDDEEATTESGDEGILKKEKKPAKSGFWRAEKRFRYCIRHTVKTQWFYWFVIVLVFLNTICVAVEHYGQPNWLALFLYYAEFVFLGLFMCEMLIKIYALGPRIYFESAFNRFDCIVIAGSIFEVVWSAYKEGSFGISVLRALRLLRIFKVTKYWSSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLFGGQFILPEGTPPTNFNTFTIALLTVFQILTGEDWNEVMYLGINSQGGHESGMIYSLYFIILTLFGNYTLLNVFLAIAVDNLANAQELTAAEEQQQERDKEKQQMELEKEMEALQKAKDGTPTTEDAEAEKEKEKESKKEEKKEEEPEEEAVEGPKPMLPYSCMFIFSSTNPMRRAAHWVVNLQYFDFFIMIVISLSSIALAAEDPVREDSPRNKVLNNLDYAFTCVFTIEMLLKVIDLGIILHPGSYLREIWNIMDAVVVGCAVVSIGFDITGSDAGADLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVGSLKNVINILIVYILFQFIFAVIAVQLFNGKFFYCTDDSKHNSIDCQGSYFIYSEVEGLPRAAKREWKTQYFNYDNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDEGPIQNFRIEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYIPTKHSGFKYTVWRIIVSAPFEYFIMSLIVFNTLLLMMKCHNQNKKLENFMKYLNMIFTGMFSVETVLKIIGFGARNFFKDAWNVFDLITVIGSIVDALILLLWENSFNVGFLRLFRAARLIKLLRQGDTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDPDTAITRHNNFRSFLDGLMLLFRCATGESWPNIMLACLKGRPCDIDAKKPDNETCGSTLAYGYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPSASGKLHYTEMYDMLKNMAPPLGFGNKCPNRLAYKKLIRMNMPVDEEGRVGFTTTLFALIRENLSIKMRPAEEMDQADTELRQTIRQIWPIQAKKMLDLLVPPNNVLNTGKMTVGKIYAGILMLETWRNNKTAQYDFEPDLQEHKGHELQEPYIDDGHLHPDQRNGHVRSPSLQRGSALERSPSPRHLHHDIGFSETVSNVVEIARRDHLIGSWSVATSPARSPSPSRLDTQISAHHRCNRRIHPYGTTSLGQRSRSPSPARLQEWRERERDRYREEIVSRPYIQHTYPVLQTHRDFGRRLPPRPIKPTTLQLKSTNINFPQLNTSPTHQNLHLALNTHTLPYSVHSLPGSRGDIPRDPRIYHHTESERDRERERLRERERDYGSRYVFRDTERELFEIERELERARDSARDTEYERVEPLSYEHLYTLGRTGGSSFGASALNGYKPKVGMHSIYSESDEGDWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTR6</accession>
    <name>A0A084WTR6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021849-RA">
        <property type="protein sequence ID" value="ASIC021849-PA"/>
        <property type="gene ID" value="ASIC021849"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021849"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785405" evidence="2">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021849-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15228" checksum="FABEB3902FBA5E88" modified="2014-10-29" version="1">MNTRVCACVKSLHFIVSTSSTAAVLAIQPKTYEPNFANLSNQTTTTSQQQTATVPSGQPREDILHAQCERTPIRLYGTATNLSRSHTRSPRPRPTMLTAERDWLTNLRVEYVRAPGGIVGKGDGGGPRNGKRVPPAGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTS8</accession>
    <name>A0A084WTS8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00021863</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2. Interacts with TASOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTS8"/>
    <dbReference type="STRING" id="74873.A0A084WTS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021863-RA">
        <property type="protein sequence ID" value="ASIC021863-PA"/>
        <property type="gene ID" value="ASIC021863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021863"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013280"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="75"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB53622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="30282" checksum="044497A0B8F33C04" modified="2014-10-29" version="1">MESTVAQYKQLKTEWTKTPINLKLCGTILDKLKVALVEMSFIPTGNASTNQQELLIARDILEIGVEYSIATKNIPAFERYILQLKWFYYDYNTLIGESKNKYQLLGLNLLFLLSQNRVAEFHTELELLPADIIQTNPFIRHPLALEQYVMEGRYNKIFQAKGNVPAESYNFFIDILLQTVRNEIGVCLESSYERISLQEAAKRLNLKTKEEVKQFGEKKGWKLGSDGFYHFVNELAKPKEPIPSQELAEQAIMYARELEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTS9</accession>
    <name>A0A084WTS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP002605-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00021864</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A084WTS9"/>
    <dbReference type="STRING" id="74873.A0A084WTS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021864-RA">
        <property type="protein sequence ID" value="ASIC021864-PA"/>
        <property type="gene ID" value="ASIC021864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021864"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007341"/>
    <dbReference type="OMA" id="CACENTP"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17725">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000008">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom"/>
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    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
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    <dbReference type="InterPro" id="IPR045080">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="477"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="646"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="730" mass="81849" checksum="F7DD1D4AA0C79A5F" modified="2014-10-29" version="1">MASVNFKSIESFSSEDPNYPASNLLKPDNKKWKCREAGEKNAFVVIRLEEPVRISGIDIGNEHSAFIEVLVARSGPSNPDFTEILLSTRFMGPVESRNSTSPNGVQIFNKSTLVPSATDDKWDLVKIICTQPFNSRVKYGLTFVTIRTASGERKEKSLVPEKFQKQIKEEAEKRHDSNVVSFGRFKLREDSPDSDGGEAAGGSLNVFARWKEKLKPNALSATTSVSALMRDSATPEAVKKNVPTPGSVRSVNTPRPKPQRFDSSDEDANLRKANDKPKANRNSVAVLYDEEDDKPDKKFNDSMARYQSAEQKQEKQRTGPKEDVSSRKSSKLHDVSSSKFREFLDLTGQSMDRDPKRTEEKHKPKVVEKPPKAFPASPPSKRTEEISKPKQAESSHRSSHSAPPPYDKNRTPAKVSTNVRTPALPIERELVPKKRLSSPSPTSKGSESCSPSSKKSKSSSPPAKSDEEVQKRVQYKPFGRLLENVVLVISGIQNPERGTIRNQALAMGAKYKPDWDSSCTHLICAYKNTPKYNQVRGKGKIIKKEWIECCYNNRKRYSWRKFAMDTDEANVSDSEDEIVDIANKPAEPVTPTDVRAEDKDDEVVEVGEPVMLHELVESDSDDGAARATRIYDVSTEDEGDANDENSNLEFFKGKTFYLDSEVGAVDVIKLEKYIRSYNGTLSKVLQDVDYVITRNKHKLPPSSKAKLVKPLWIYECGEMECLIPIDRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTT1</accession>
    <name>A0A084WTT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP002603-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021866</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTT1"/>
    <dbReference type="STRING" id="74873.A0A084WTT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021866-RA">
        <property type="protein sequence ID" value="ASIC021866-PA"/>
        <property type="gene ID" value="ASIC021866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021866"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004977"/>
    <dbReference type="OMA" id="FCICGRI"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000035">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="276"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB53625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="702" mass="77584" checksum="277A00535630C679" modified="2014-10-29" version="1">MSRHRNVRNAVYDDYDDDDDYQYGRSVEDDCISPTDAQQWMYDRARGQQSMSEFLANNRDIEEEDDEEIAVAAAGTAHKRRDSECYQMPELNDEDRARLLSCMDEIRDIIGDSSSDRQMVEAIMKHDYDCSKALDEILNSNKTPPTAGRSGAKLTSEKIEKGIGERLLERSEKKLQTASQNVPIVIATPAAEPSLPARSSMAASTVVITPVAKKTLGFEISSPQGQSPSVSGRNTPEPGSDEGKLQQLNNQSVRSTPKEPVRNAKELFTKERGTRKEHIHMVVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERERGITMDVGSTRFETATKEITLLDAPGHKDFIPNMISGANQADVALLVVDATRGEFETGFEQGGQTREHALLVRSLGVSQLGVVVNKLDTVGWSKDRFDEIVNKLKVFLKQAGFRDSDVTYVPCSGLTGENLVKDPTDPGLIQWYNGPTLLKVIDTFKTPERAIDKPFRMSVADIFKGTGSGFCICGRIESGVVCINDKLLVCPSKEQAVVKNITIDELPQQTAFAGDQISLTLANIDISNVAVGYILSSIYHPVPLATRILARIVVFNIKVPITMGYPVLLHHQSLIEPATIRKLKAQLHKGTGEVVKKHPRCLGNNSCALVELEFQRPIGMERYADFKDLGRIMLRVGGVTIAAGLVTEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTV1</accession>
    <name>A0A084WTV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004546-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00021888</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026919">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTV1"/>
    <dbReference type="STRING" id="74873.A0A084WTV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021888-RA">
        <property type="protein sequence ID" value="ASIC021888-PA"/>
        <property type="gene ID" value="ASIC021888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021888"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019658"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="810"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB53645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="902" mass="104539" checksum="09BFB030660213B0" modified="2014-10-29" version="1">MPYIAPPIVQQQPMIPAMNQPPPSNRGGSFRSGATIGSRPQMYNNKPPPQPEPVYDGPIVTVFVGNISEKVPDPMINRYWQPAAQFPAGGARAVRLVHDLEVGGKKLVAKVDAKNKALLDSFREDENNAETTNEASEKRGDDDAMESINRILEDFREELAAAEQQQEETQAKQKKMLQTVDIEDGKRDIINKEIGKFRKYTEEEELKKEKEKERKKREEKRTEEKQRRSASPRKDKKPPAASSSSSRRRSRSRSRDRERDREREREREQREREKERERERERELRERERERERERDLERQRERERERERERDREREREREREDLKVSRNPRDIQKEKEMEEEARERKKAEKKARDKEAAYQERLRNWEARERRKAKDYEKEREKDRCKEEEREKEAKRLKEFLEDYDDDRDDPKYYKGRELQRRLAERVREADADSKDRNKEQEELDELKNKIFSGEYDNPTLEFEKAKKEREDLYKPKILIDVNLEQSQQREREMERERMREIERQRAKERERMNKERYVLAQASRELASVDAEPIDSDSSGQDNFNSPAGSAQQAISGASNGPGSGSASMTDGLGNSNHHHHHPHQSHHHAHHHHHHHHSHHGASEQRVASAGQHPAHAGSETRDSFGLMGHGGTAGGGGGSSSAMMGMMNDENSRHSSRSNSQHGVPESPEPDTNSGMNSLSDKSAHHHQHQPQPQQSTVGPTISLNLNVNAKKKKLEVKDVFNSLDDDTEESNGPKKRKLVPLEYEDGRGQTDTPTGTANSTPAGPNPKSSKGRRDEASTRESQKSQEEKRKNIKSIIDKIPTEKNDLFNYPLDWNEIDSTIEKKIRPWINKKIIEYIGEPEPTLVDFICSKVLAGSTPQGILDDVQMVLDEEAEVFVVKMWRLLIYEVEAKKVGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUT5</accession>
    <name>A0A084WUT5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative monovalent cation/H+ antiporter 3 subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022230</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022230-RA">
        <property type="protein sequence ID" value="ASIC022230-PA"/>
        <property type="gene ID" value="ASIC022230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022230"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8492" checksum="CF1BAE4EEB2B8035" modified="2014-10-29" version="1">MRTHQFHGTCMAMGIVGTEQIGVTNEEVSDHREIVVTLGITIGIVVDKTTQPMHGWQLYHHSKTLKKHQTLTRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUT7</accession>
    <name>A0A084WUT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nicotinate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022232</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022232-RA">
        <property type="protein sequence ID" value="ASIC022232-PA"/>
        <property type="gene ID" value="ASIC022232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022232"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6551" checksum="52E51E35E0C26B48" modified="2014-10-29" version="1">MALAELSLNRNYATIGGRYAIKTVRLKACLGTIKPKPFWILPVGRPGLGCASHSFGTASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9T2</accession>
    <name>A0A084V9T2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000010</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000039">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523844">
        <property type="protein sequence ID" value="KFB34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9T2"/>
    <dbReference type="STRING" id="74873.A0A084V9T2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000010-RA">
        <property type="protein sequence ID" value="ASIC000010-PA"/>
        <property type="gene ID" value="ASIC000010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000010"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009375"/>
    <dbReference type="OrthoDB" id="7744478at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000010-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12403" checksum="D8FCDD389B8C0F3A" modified="2014-10-29" version="1">MKSGAILYNLFQGLPVTTHLDAVPQLLIGLQDVALLEPLETRSGETGEPIAVRCPLGWAIYGPYDKVNRAAAKASDVQPAEGEMTSVPSVVASDGQPEEGERPPRANPILNWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBU1</accession>
    <name>A0A084VBU1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002118</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009470">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524531">
        <property type="protein sequence ID" value="KFB35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBU1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002118-RA">
        <property type="protein sequence ID" value="ASIC002118-PA"/>
        <property type="gene ID" value="ASIC002118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002118"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9296" checksum="09C31A51129CF252" modified="2014-10-29" version="1">MNGNGTGSNAICASFALPLHRIGLHFRQRGGSRGHRAKAVKKTRLDGGKVLRDAFVLDTTFRGCRFVKSSDEAERMNFCREKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC34</accession>
    <name>A0A084VC34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002329</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524565">
        <property type="protein sequence ID" value="KFB35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002329-RA">
        <property type="protein sequence ID" value="ASIC002329-PA"/>
        <property type="gene ID" value="ASIC002329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002329"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10795" checksum="D9D1A6C354A5BC30" modified="2014-10-29" version="1">MAKTPPKAGGSMADYAFRHRITYRKHSTPTATEASEVLMASGCGDGRNGEKCGGAGIRGKHKHGEYEHEHHIFLSKVQRLMVDLESQHRFAAYDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC55</accession>
    <name>A0A084VC55_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01010510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524585">
        <property type="protein sequence ID" value="KFB35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC55"/>
    <dbReference type="STRING" id="74873.A0A084VC55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002411-RA">
        <property type="protein sequence ID" value="ASIC002411-PA"/>
        <property type="gene ID" value="ASIC002411"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002411"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014300"/>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002411-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="367" mass="43226" checksum="32D5E20189D1C9FA" modified="2014-10-29" version="1">MEGLLLNAERQYDGSAAQLKYLSLPSEPRTNLHLDLNEGFEIRRPKPDSAKGERIDMLLKFIQQNEGANLWTRRLPDDELASGNMLHRLRYDFVCFRGLLRLIACTPYEWKTGWIVQAMRYRDTIYLCEKPTAEKLEAERNETEQQQRFCYYGFKFEQHILTSQPNEKPDTSEPVVIGEEFCSLFDSTLGGSRVLYGAEMDGIVTDTPVDRDRLCVDDLRRQEFVEVKVKRKETTQRQRDNFYRFKTKNWWCQSFLVNVQRLIVGLRDDDGIVREIMEMSLKDIDRDSRQYWSAAVCMNFCAEFLREVANIMHRVDSCRTVYQFEYNSTDSRLVRYRVLDEGHSDAFLPSWYTEYVEGMNAAEDEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC76</accession>
    <name>A0A084VC76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001535-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010535">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524586">
        <property type="protein sequence ID" value="KFB35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VC76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002417-RA">
        <property type="protein sequence ID" value="ASIC002417-PA"/>
        <property type="gene ID" value="ASIC002417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002417"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001853"/>
    <dbReference type="OMA" id="WQSCEFL"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1317" mass="134404" checksum="7C83E4A1B8179082" modified="2014-10-29" version="1">MTTVKSNSTEGNQPDKGKSPLSSSSSSSSSSDSDDGTDSSSESDSSSASNSKTSSKQSNGQTAEKPTQFSVTSSDGHLRMKIAIPRSQSNSTPTPSPTSAGSSGIASGQHQQQLSPRDGKQKTVEHGASGASSQLHPATCLPSAGSDGSGVGKSTEPYKAGHEKRDKSATVGAEARSGSGRQHAQSGLSDKPSGRMNKPDGGRKGSDGRTNQAGPKGSKRTAVAGVPGKRKKSVSESDSSSPSSSYSSCSSNSDSETSSSAAENGSGLPGGKKTTGGSGDPTRTTAKAGSAAGKKQKLLKRKKANRSGTTSSSEDEREDAPVAGGNRGGQVHATNQSSDCDSSSSDDEGKRFSHARTSKAKQMGQAKVSRSDMEDLPSVGPPLSTSTPAKQPYASMGMSLMTATVPPPTVDGGLTAEGGSCSSDNELPALVSAAIRRVESGSDAESIRGTNAGPTQQYTSSLLREFVVKTQMLGSVEGGGSGGGTAGGSVPVGAGTGGLSKATATQRSPSSSSSSSSSSGGSSSSSSSSSVDEGGPDPAIGSAGPGPGGGVDLDVRKIKTESPVPAAIGGRSTPLVNGVTSAGGQHQLPPAPAAPRRRGRPPKSSLANAAAVKATTTGINSKPVAIPIVSESPDSGILSTHSSSTGSPKQKEKQKGATAATIASRRSKSEASRGNELPSSASIARSSPVPTAATTSSTSRGASTSYAINSCLDRNTYATERVLYPPRSAKKRGVGRPPKKDTQQQQQQARGHTNGPLSKIDISKKFHEPRLSGYKSDGGHSTICCSKRLASQSGYISDYGGVGASGGGRSRLSGYKSDYSARSRRSCGRSGGGGYRSDYGRARSCGYRSDCSTRHRKQVRRKRRKKIPTEQHQQPEQAHHNNNVDDRKNYNSASGAAGGGSNSGSKSASVGELEIMFMAGLTLGSTSDEDDSSSTSSSTSSSSAGSRESLFSAASTTAVPPPPSATPGVPLGKGARKRLPTPPPPQAVKHKEVKALVQRLPKTPRKPAASRKPSPVKPPGARARAKSVSAVDRRRHTLADLDDDDVEDRWLGGGGGSRVRNKTQQATVAPTPKPSIAATASVALKQKSSAMVRKPGQRGRPPGSVKKPPPAPPTPPADPVPSTLLPKSSAGRLDVLLAPGGGGGDGRSGVARLPVNNFGGVFASMCGKKSDQAIFAFSSSTVEAKNSFAAYLLRDAASRSKEQPEGSGAGGNNLVVPPVKKGLPLSKANVIKNSEECNKRFQRSSSSFALSVVGGGRSVGASRRRYDPEGVTYEVGVLEAKPPEELHQRPVGGDVGQELRRVREDSPAAPEHDESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCK8</accession>
    <name>A0A084VCK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Pol-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002602</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524617">
        <property type="protein sequence ID" value="KFB35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002602-RA">
        <property type="protein sequence ID" value="ASIC002602-PA"/>
        <property type="gene ID" value="ASIC002602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002602"/>
    <dbReference type="OrthoDB" id="7762009at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6555" checksum="0C37EA39F683835D" modified="2014-10-29" version="1">MSQYPPRVAWKNIWKNIHYTTLKSEQRSELYILVNGKILHGEDRPCILSGMYVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDM0</accession>
    <name>A0A084VDM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Rac gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00003093</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDM0"/>
    <dbReference type="STRING" id="74873.A0A084VDM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003093-RA">
        <property type="protein sequence ID" value="ASIC003093-PA"/>
        <property type="gene ID" value="ASIC003093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003093"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009912"/>
    <dbReference type="OMA" id="CPMIPPK"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:actin filament bundle assembly"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:dorsal appendage formation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:dorsal closure, elongation of leading edge cells"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:germ-band shortening"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:head involution"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:lamellipodium assembly"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:melanotic encapsulation of foreign target"/>
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        <property type="term" value="P:mesodermal cell migration"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:myoblast fusion"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090303">
        <property type="term" value="P:positive regulation of wound healing"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903391">
        <property type="term" value="P:regulation of adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007426">
        <property type="term" value="P:tracheal outgrowth, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21253" checksum="779A43AC939AB1BC" modified="2014-10-29" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPNIPIILVGTKLDLRDDKNTVDKLRDKKLSPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRAVLCPMIPPKKSKCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE03</accession>
    <name>A0A084VE03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003282</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524748">
        <property type="protein sequence ID" value="KFB36197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003282-RA">
        <property type="protein sequence ID" value="ASIC003282-PA"/>
        <property type="gene ID" value="ASIC003282"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003282"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003282-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="21217" checksum="CCF8A68C49FBA57C" modified="2014-10-29" version="1">MPRSRRDAGQTSSGWSRRVPRAKNSDRSLPAENGIVFLRAGPINMRRRIRCSHTNIHPDSGDRSHGGTNETERPRRAHQTHPTDIVFVAHTCAVPPSPCALAGSSHPHRAACCQQSFPLGATEKNHRTEKVIKFTHNVKVSRGGTPRKKENDEMMLQMHNLPAAACSNSWHGNYIMAIVHLNQINWSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEM2</accession>
    <name>A0A084VEM2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Flagellar export protein FliJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003583</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003583-RA">
        <property type="protein sequence ID" value="ASIC003583-PA"/>
        <property type="gene ID" value="ASIC003583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003583"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="17253" checksum="D991E079B083F640" modified="2014-10-29" version="1">MISSNLPPRLRSIASGEGCHREGGGKGASCRRNVHFLIDVTFGRHCWRTFQRAAPAQFSRSSVTWLIDFRSRTRDVSIIGQKQRYARRLVGKACCARQCAWFRLVPRLKSTPSLVQASITTCAPFYNVRTDRHRPARASKSGPTDGSIGGREFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF89</accession>
    <name>A0A084VF89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007659-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00003687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003687-RA">
        <property type="protein sequence ID" value="ASIC003687-PA"/>
        <property type="gene ID" value="ASIC003687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003687"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014974"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783558" evidence="2">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="264" mass="28387" checksum="D5172C7009762F39" modified="2014-10-29" version="1">MVLKILRGIVCVATVCVVLGTMAVAIGADQPVANNVVSASKNTQPSDTQQQHPSAHEGNNGTVPAAAEVVPCGSATDGGGGAEPQSRRPVAARSKLNNGTCVSAFCAATDADPGDDDVDDDADHRNTSATGRGVDVINGTAPLRRQQHQKRRMHQQLHRNVARAHLQQTAAEDIDDDPFVYGSKKVVLKADVLRHTSVLYGLLSIADRDGLSERCYRELQRVYDGIQQKEIWAMKDKLEKAHLRVSADLAPSSDSWHAEERVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGB7</accession>
    <name>A0A084VGB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004187</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524812">
        <property type="protein sequence ID" value="KFB37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004187-RA">
        <property type="protein sequence ID" value="ASIC004187-PA"/>
        <property type="gene ID" value="ASIC004187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004187"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004187-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13747" checksum="7FBB3F77DCA24215" modified="2014-10-29" version="1">MFLFLTPILEGVDRTWIAKPYGTVGTPHLRRYHSPGPVTRNDKLFASPPPVKKHGCPAEQLIPPDSNFPQTQPTGSPHQRVFGVGVGKERHRWMGGKPPRPSTRREMMRGWSTKSRHDVGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGH3</accession>
    <name>A0A084VGH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004275</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524827">
        <property type="protein sequence ID" value="KFB37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004275-RA">
        <property type="protein sequence ID" value="ASIC004275-PA"/>
        <property type="gene ID" value="ASIC004275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004275"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="14797" checksum="C4AD7B32565B9BEC" modified="2014-10-29" version="1">MRNALRPLALPTHAATHTFFLATANNFLASTTGKLVVRNSRAIECDELTQLRHRLSVEEKKSDLKKVNSFSGRPGVEGGGVWAKESSVLSRKWIGTSNPRPAVSLGNAEVKNKCISMMVEAEKFVLRMKNALSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHN3</accession>
    <name>A0A084VHN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004729</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004729-RA">
        <property type="protein sequence ID" value="ASIC004729-PA"/>
        <property type="gene ID" value="ASIC004729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004729"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014481"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004729-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10275" checksum="D203EB900B57A019" modified="2014-10-29" version="1">MDEVNNPNPDWIDILFTAEHRNGRLQCLGGKYVANYAPCKCSAFRWLSLNYPFLPGVTANGSTILCAQDCVKCDNGFQAKSKMSNGDRRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJS8</accession>
    <name>A0A084VJS8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013088-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005537</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005537-RA">
        <property type="protein sequence ID" value="ASIC005537-PA"/>
        <property type="gene ID" value="ASIC005537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005537"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005537-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6530" checksum="41E516A8F2AB8D25" modified="2014-10-29" version="1">MVQITSSTRKQEKPSFRIIAPEFICHPERSRGKSVSNATDSVQRNSSESAANPRQLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK62</accession>
    <name>A0A084VK62_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Adk3</name>
        <name evidence="10" type="ORF">ZHAS_00005710</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01014114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK62"/>
    <dbReference type="STRING" id="74873.A0A084VK62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005710-RA">
        <property type="protein sequence ID" value="ASIC005710-PA"/>
        <property type="gene ID" value="ASIC005710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005710"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013515"/>
    <dbReference type="OMA" id="TIAHFST"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005710-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="216" mass="24559" checksum="AF3EB11D95377E3B" modified="2014-10-29" version="1">MASSRLFRAIIMGAPGSGKGTVSGRIVKNFNLKHISSGDLLRANIEKRTELGRIADKYIREGKLVPDIYITKCILGELDQIKAHSWLLDGFPRTREQADDLWQQERIDSVINLDVPFEVIIERIQSRWVHLPSGRVYNVGFNDPKVAGRDDVTGEPLSQRPDDNPVAVRKRLEVYDACTRPINEYFEKKGVLATFKGSTTDEIWPHVKQYLEAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKB7</accession>
    <name>A0A084VKB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005771-RA">
        <property type="protein sequence ID" value="ASIC005771-PA"/>
        <property type="gene ID" value="ASIC005771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015092"/>
    <dbReference type="OrthoDB" id="7740752at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="20244" checksum="15DD25784D86B494" modified="2014-10-29" version="1">MLIYTRRVKQLAVNLVFFLVYPFILLWRWYRSSEWTAWTDVEKDLFEQHVELGEDELLRRGSLRGRMIIQKEIVVSPAAATEENVPFERYERAEEEFVETGTVYSNSGAELHDEEMPLNLSKGNEMNFHAEYEALNRKESYAPTENDEEDIANEEPDEGEEVPLIVPSSETQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKC4</accession>
    <name>A0A084VKC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004291-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005780</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKC4"/>
    <dbReference type="STRING" id="74873.A0A084VKC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005780-RA">
        <property type="protein sequence ID" value="ASIC005780-PA"/>
        <property type="gene ID" value="ASIC005780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005780"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012754"/>
    <dbReference type="OMA" id="DQNLEYA"/>
    <dbReference type="OrthoDB" id="10025511at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000060">
        <property type="entry name" value="Protein phosphatase 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113745" checksum="9F7EDD12AAE069B2" modified="2014-10-29" version="1">MSIGVNLRVTGHTSIGGRKYQEDYFSVAYQQTENDQNLEYAFFGIYDGHGGAEASLFAKEHLMNTIVSQKQFWSENDEDVLKSIREGYIQTHYSMWREQDKWPKTSSGLPSTAGTTASIAFIRRGKIYIGHVGDSGIVLGYQKDKESPHDDDGRWVASPLTEDHKPESYAEKMRIMSCGGKVVTKSGVPRVVWNRPRIGHKGPVRRSTPIDEIPFLAVARSLGDLWSYNSAVDEFIVSPMPDVSVIEIDPKKFRCLIFGTDGLWNVISPKSAVEIVRNTEMENIRIALEGGSEWKNPSKLLVNEALERWSRSNMKADNTSVVIIMLDPPGPPKRDVLKSVKDSIQYASPEWRSASGAPGSDMFDLFDCITRGEAVPVLSQMAQRTEPSDTPSMRYLHHHHNHHHQQQQHYQQHRNYHEPPQQSMHQEQYAGNHPQQDHQHLDHHHHPEQYCHPGGSTSYDHDLAYRDTSFAESYNSLLDRSFENTDHSYTSIFHQTADEEGASTSAYQNRATRVEPSLEVGHTDDTDEEALIDYQPESDDETTGDGLVGRRDSTYSLTNLQTKSERLHAAMVESERSSQSHPYYHHHPQHRREEEEGCYSGGNLAIIEHFHNYHHPLPHHYGSGASSRAGHTEDAHHQYHQGMYQGLDVTHQYQHHHQDVGGHYEQTHFHHASSSYQMERYDYRHPTNNNLLVCEPSCSTGTGTKVKSDNELAFANVYNEGGTLQQPAEEMDMEEENEEAIEESVESPSDVHRIQINEISSSYAGTTNASPGLILPSESDGHGSGCASGDEENSASSTTQQILSVPTFESKPRTIKKSAPSPRVITIFYETRSSRRKPRIRSATSGLTPSKPRSLLGVASFNRIATKKRKTSTTTVVQTAIPSDDPTPSNPTLTIERRILRSNGMNTRARSYSNQPSTRVHPKTHVQPKFVLNNNFAVSSTTLERIPATQQNTETNSLRHNPNPVCRHRKRDTIVATLVRTSEVVEKRKQTPKPVIQQRTMLLRRTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKE6</accession>
    <name>A0A084VKE6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005886</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014188">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKE6"/>
    <dbReference type="STRING" id="74873.A0A084VKE6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005886-RA">
        <property type="protein sequence ID" value="ASIC005886-PA"/>
        <property type="gene ID" value="ASIC005886"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005886"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005181"/>
    <dbReference type="OMA" id="WIDSEEC"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005886-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="30870" checksum="3D3989FCB617CFCE" modified="2014-10-29" version="1">MHEQQNAQTKTYQETLQTELKKLGENTKTIKMLTGSDQNISVQTKPNTFVTYPVRSCRQAPYGSGIYLLKIRVKSIPFEVLCEQNTNFGGGWIVIQHRFNGSVDFYRNWTEYRDGFGTMDGEFWLGLEHIHQITKNRPHELLIEIKDFYGNNGSYSYSVFEIGSQYEHFMLKKLDLTRGELDSMYENKGKKFSTFDRDYDEWTDGSDAQYYHGAWWYGYSTSSNLNGHYQNTAKSEGAMYWHYFKNDTRGLSYSRMMIRDISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLB9</accession>
    <name>A0A084VLB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4789 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006164-RA">
        <property type="protein sequence ID" value="ASIC006164-PA"/>
        <property type="gene ID" value="ASIC006164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006164"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017333"/>
    <dbReference type="OMA" id="FCQPGEY"/>
    <dbReference type="OrthoDB" id="6338576at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF4">
        <property type="entry name" value="IP06524P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783629" evidence="1">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="23237" checksum="59485B07152ED28C" modified="2014-10-29" version="1">MMDKFYFTLCVVFLYTAVQLSTCGPAIELFAYPADEAEQIKEYLQNAHNRTPVFIPGKCSPNEILYPGDHADDWVCDCRPGYVYYPNNDSCYALFTKGFCQPGEYVDLERPSMLVKCTQNTCTDGKKVPFRGQCVELNRHDKACPVVKRKRFVVGVNTTTLQLDCVVGELDLGRGDYNGLVLFEGAKRCSSGTKASYNELCVENTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLP4</accession>
    <name>A0A084VLP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Serine/threonine-protein kinase TIO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006203-RA">
        <property type="protein sequence ID" value="ASIC006203-PA"/>
        <property type="gene ID" value="ASIC006203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006203"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006203-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="8881" checksum="5D5C64A1A1A4B15E" modified="2014-10-29" version="1">MPALCPVVRNTAGSGGGGGGRGNRVSRTAVSDVLALIDRSIRSDPSIPRSPRAARGDTMVFSPASPQFVFGTSQDYLAKAKEPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM29</accession>
    <name>A0A084VM29_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="18">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00006733</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="18"/>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM29"/>
    <dbReference type="STRING" id="74873.A0A084VM29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006733-RA">
        <property type="protein sequence ID" value="ASIC006733-PA"/>
        <property type="gene ID" value="ASIC006733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006733"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000843"/>
    <dbReference type="OMA" id="FGAEGNE"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000008">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000013">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11 19" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="21">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="21">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="450" mass="50454" checksum="8313A6B4663A4EF2" modified="2014-10-29" version="1">MEEYIDLSGDGGVQKRILQEGTGDEKPSKGCSVSLHYTGTLDADGKKFDSSRDRNEPFQFTLGQGSVIKAFDMGVASMKLGEKCILKCAPQYAYGSSGSPPNIPPNATLNFELEILGWKGEDLSPKSDGGIQRFILKSGTGKRRPNAGGMVKIHLVGRHEGRVFEERDVEFSLDEGKEVGVVSGIELALEKFHKEETSRLILKPQYAFGAEGNAGLGVPANATVEYTVTLQDFECLVERSMMSPEEMLAQAKLLREKGTKYLKEEKPELALKLYERALTFLFDQSAETEAMKLAIYLNKILCLQKMKDHDEAKVACGEALNLDSKNVKALYRRGMSNLALGDLDRALQDFTAVLDIEPENKAALNQVTICKHKIKEYNDQQKKVFANMFTKFAQSDSKKAQEEQSRQPDVMKQKFGEWGDDEREHEPTRFEQENPDVIMLNDLHKQFRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNG9</accession>
    <name>A0A084VNG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014747">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNG9"/>
    <dbReference type="STRING" id="74873.A0A084VNG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006854-RA">
        <property type="protein sequence ID" value="ASIC006854-PA"/>
        <property type="gene ID" value="ASIC006854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006854"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021935"/>
    <dbReference type="OMA" id="DMTEYYE"/>
    <dbReference type="OrthoDB" id="9876293at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="238" mass="27703" checksum="D95F24177090AF91" modified="2014-10-29" version="1">MYPVYEVWEWVFRFQARMDQKLFLREINGWYAGSHCSCVLILEINSEVALFRDLLIHVGQSRDCPELREKIRKLRRSCVEACKHTAALILPQIRTAIAEGILTDNPHLVLLFYLAQLFLRELIKSHRLVQVIPMDMSGYYENRAGPSNLGNVISQILLCKQITPDFNQEELCSITKDSQEIARILQELQEFMPQQETYLERTIALTNEINGPWPAKRRRGSLYKNMGLLCCVSRPNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNS8</accession>
    <name>A0A084VNS8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Isocitrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007064</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014866">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524991">
        <property type="protein sequence ID" value="KFB39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007064-RA">
        <property type="protein sequence ID" value="ASIC007064-PA"/>
        <property type="gene ID" value="ASIC007064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007064"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7016" checksum="E410A5AC043375B5" modified="2014-10-29" version="1">MLKEETDRGTENREIIVQVAVRPPVPAVGRAEGGPIFSQQDPAALLRRRRNYPGLWNIMICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP49</accession>
    <name>A0A084VP49_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007436</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01014977">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP49"/>
    <dbReference type="STRING" id="74873.A0A084VP49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007436-RA">
        <property type="protein sequence ID" value="ASIC007436-PA"/>
        <property type="gene ID" value="ASIC007436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007436"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016003"/>
    <dbReference type="OMA" id="THCTVPW"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="488" mass="54035" checksum="9661B3218CB4EDB6" modified="2014-10-29" version="1">MGEQYETVAKELKKWNQAHLLKFWDELSDSDRNKLLDSLSDSVDCAALDEAFRRAMATATSAKEDLNELLQPIAKELSLSVADASETELNDLRQTGLEQIREGRVGVILLAGGQGTRLGSTAPKGTYNVGLPSGKSLFQLQAERIRKLQQLAGGHGRIRWYIMTSEHTHTETLEYFKANRYFGLPAEQVRLFRQRSVPCVDFEGRILLDEKWKVATAPDGNGGIYRALKDEGILDELEREGVLYLHAHSVDNILIKVADPVFIGYCVRKRADCGVKVIEKVQPDEAVGVVCEVKGKYQVVEYSELSSETANRRNPADGKLTFNAGNICNHFFTSAFLRRIADTMMPLHVAKKKIPFVDTATGERCKPSSPNGIKMEKFIFDVFPLAERFVALEGRREEEFSALKNADSAGIDCPSSVRGDIARLHRQWLINAGATEVTETTTAEGNVVIDCEISPLLSYAGEGLEPVAAGQSFRCPVHLIGADEQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPQ2</accession>
    <name>A0A084VPQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007329</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPQ2"/>
    <dbReference type="STRING" id="74873.A0A084VPQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007329-RA">
        <property type="protein sequence ID" value="ASIC007329-PA"/>
        <property type="gene ID" value="ASIC007329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007329"/>
    <dbReference type="OMA" id="MAIGCQC"/>
    <dbReference type="OrthoDB" id="7587298at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF133">
        <property type="entry name" value="GH24286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5594" checksum="E7BA9124FFDC35B0" modified="2014-10-29" version="1">MCLSASKPPHWYVIGRDILKDISGEFRAGELTAIMGPSGAGKSTLLDILAGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPR4</accession>
    <name>A0A084VPR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP009457-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007342</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPR4"/>
    <dbReference type="STRING" id="74873.A0A084VPR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007342-RA">
        <property type="protein sequence ID" value="ASIC007342-PA"/>
        <property type="gene ID" value="ASIC007342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007342"/>
    <dbReference type="OMA" id="HLMEEDH"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="9210" checksum="C2F8EFDF961B6082" modified="2014-10-29" version="1">MAASTNRRRESTLSKLSCSRCCGDLFGYLLRLRVSPEELEQRYKSREIDKFLEKDKHAFRRQVSEQIAILCVIDRWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQS4</accession>
    <name>A0A084VQS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP007280-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00007807</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VQS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007807-RA">
        <property type="protein sequence ID" value="ASIC007807-PA"/>
        <property type="gene ID" value="ASIC007807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007807"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000374"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004628"/>
    <dbReference type="OMA" id="DCMSAFL"/>
    <dbReference type="OrthoDB" id="10016557at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000111">
        <property type="entry name" value="Blast:Serine protease nudel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015420">
        <property type="entry name" value="Peptidase_S1A_nudel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF140">
        <property type="entry name" value="BCDNA.GH08420-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09342">
        <property type="entry name" value="DUF1986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1515"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="189"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1386"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1608"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2117"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2124"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="2206"/>
            <end position="2221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2355" mass="262961" checksum="9CFA449A89BF62BB" modified="2014-10-29" version="1">MIKLDQMAQDEDLSTSSDGTHRLSNVHRTNLLCLMLTAVGGVIIIGTIAFGFYMCMPASDLNPLPSPAVLIAIKEEYEVSQGPFGDETDDIGVRNFKREAYNALVRSLELLELMEDLEPMYESHQRMKRDLPEPAPNRISRDDRSEEITYGVRRRVQREDDLGTLPIAYGGFYAGNGARGPRRKRHLSLEELERAKRNAQKDYHRLEHEYYRCRKEAPNAKICDQIYEKLQRLSEEVNARFQEMANLLQNIQEPATSKSPSFPSMVFGVTEAPKTKVTVVTPPRTTTYRTESHVPKYDPEIETVEQLVNQMNISQGSSNSESSVRKFDPRLHYPVENSSIQTLDDLFDHIDLGFVVTTELPKGTTVGYEFDSNTSHSSPSYSVSSSTTVRSRTTTVPQRTTTDHDSEETSFEPNRGSYVKPSTPPPSRWSTTKSPSQAARNLHDVVEQLQLAQMLQMQPAPFHEDLGSPPSSISEFVMARSRNRDHTHHDHDQPTGLEPDPVASSFSDGSETLRSAQHQLVVGPSAPFLNLCEQLRSANGGGSSHTGHVKPTHTGTFHTGSVQPGIPFTGEATKASSQIIVNSAYGAGYVPNTVCFYQNAPPTAAVQTPYAFRPANTYSYPNGAYSPAYQHHQQPHPAAGGKLPLNDPAIDALLEPRIPQAMINMPVSIQNHQHPGSRASEGSNVPNNPILLCSMMYNGEQHAGLPPAAATVPQPTYSAPSRHQFGNETAEPGEEGEDLASMFASGRSLAARAKGRHHCRRGWVPCFSSHQCVRRKSWCDSKTDCMDGSDESACSCVSRLPKRKLCDGYADCPLGMDEMGCFGCEKFSFSCFHNEAEYQVAHRSGSMCYTLIEKCDGFDNCLNRKDEEDCTMLVRDLGHYLAYSVPHSSGVLHRNYKGKWYPVCHNGVQWAREACEAELGPLTREPLLSHGHGALPGPYISQAEDSAVAQPVFSETCNGVYLNVKCPPVHCGTSKLHEMHSARVSVRTRRNVTTEDELVEAVRIVGGSDAEPGAYPFIVGIFRDGKFHCGGSIYNEHWIISAAHCCDNFQHHYFEVRSGMLRKRSFAPQVQVTRVTHMIVHHAYSATLMANDIALMRVEHPFHYNRWVRPICLPAKHRTTNDRDWLWGPPPGTVCTAVGWGALRERGGAPDHLKEVSVPILRTCKHKVDRDSLQICAAEEEGGHDACQGDSGGPFVCKSSANPYEWYLAGVVSHGEGCARAHEPGVYTRVALFVDWIAQKVREPLPGRMAGSDCPGMRCIWGGGVCLPPGKKCNGFVNCLGGEDESGCEMDRLLRSMSNRGDEESEELSTTPRDMGFHENRQTDDDGESTDTVETTSVAPVEETPTLSVDLTTVKPEEATTTTPEESAEAQESVIVTHTVHADVVETTTPTPKETTTDEPSTTQASSSELSTTETSTTEASTFESTTTEKSTTTEEPSSTVNPSTTEQVTTTTSSTTVQAETTDSSAIVFHDDTITTQGSIEFEIIAPSVPTTTEAIWKAVEKTVQEVRGQARVENGSVPLMTDETSTGSEPTDEPQDDLLDPSDHPFFEEIDTMHKEKHKRVAKFRMTVHNLHTKTNAQLVPANVTAKYRQFWCQNITQRINMAHRCDRIIDCEDGSDELNCTCRDFLKDKFDFLICDGKTDCLDRTDEENCMDCHVDQYACRISQECIPKEKVCNGHPDCRLHEDELDCLALTDGHRVYFDANNLTLFRNTGIVTKNTNGTWEVVCGAVLTGKTEHAVEKICSFLGFAGSRNYSLVTLEQHELPVEVLVGDNYQNLTVTPACQALKVSCAQHINATEHEIAHFDPKPTEEPVQVDIRPLNPIHRPHHMPQIVFQENAHIELIENFGDDYDWPWNTNIYLDGVLICSGLIIDAAWIIVASSCTRLVNMRHQYVAVVAGGAKSYLHIAGPYEQVVRVDCYHFIPEAETVMLHLEHKLNFSRHVLPTFVPENENVTDSECLAVGQDKYGRTKTLRVHLNSTNCQGERVRCYHKDLKQPYFHHEYCYTQEATRSGVIVCKTSRSGWYPVGFYQNKRGLCGFNEVVRVTSLVESYHKIQHVLHREQCAGQYYEEPKCTGKRCRYGKCVGETLLCDRKNDCGDGSDEDQAFCAARNQTTSCLPHQLRCANGKCIDKSSFCDRKNDCGDSTDEPHDCSCYTYLRITDPGKICDGVRNCWDKSDENPRVCRCHATSFRCGESDICVPYDFVCDKERDCPNGEDELYCYALQQNSYEAGYGELMEQSYGIWHSKCFPKTAQFDDEYMRRVCEQLGYTQVRKIYGRAIVEEARLRTTANDTESPVEKLRRAATKTVVQNKFSKVVINANQTFYMKPSRPMFKVINWDQEDQQNCHRLELLCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRD1</accession>
    <name>A0A084VRD1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008019</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRD1"/>
    <dbReference type="STRING" id="74873.A0A084VRD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008019-RA">
        <property type="protein sequence ID" value="ASIC008019-PA"/>
        <property type="gene ID" value="ASIC008019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008019"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016011"/>
    <dbReference type="OMA" id="DIMAQGI"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="11400" checksum="3236EBF4ECC9FBAE" modified="2014-10-29" version="1">MRYVAAYLLAVLGGNAAPTNADIEKILSSVGIEADATRVSKVVSELKDKSIEELIASGREKLSSMPSGGGAAAAGAPAAAGAAAAAAPAAEKKEEKKEESESEDDDMGFGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRN5</accession>
    <name>A0A084VRN5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001812-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRN5"/>
    <dbReference type="STRING" id="74873.A0A084VRN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008301-RA">
        <property type="protein sequence ID" value="ASIC008301-PA"/>
        <property type="gene ID" value="ASIC008301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008301"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020112"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784022" evidence="1">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="339" mass="38986" checksum="3853C8BA9F32D52C" modified="2014-10-29" version="1">MKSLLTWMVFSLIACGQCSRLHLIEHFLQQRSINTLLLLHCVQETVDQDVVRISKALRQSFRGSIYHIDVTKNHFHQQLGWHMYCERYKTAVIYNLECSGTEAVLDRLSEKAYFNASFQWLMFGGQNMELATSLLSQQNINYDTKMLLVFESVDPEKQREQRYEFYDVSGTVKRRGGKVIFTPLGFSTPENVLPTIVPQKPDLKGIVLWTVVSFYSTFIVGYQLISPPKTINTLEKLADSSLKMGVENLSYQHDFFARTTNPIALKLYNEKIAPNKYGFVNLTFGIQLVKGGGYAFHCDTTYGYTHVLEMLTEQQICELQEIELYPQRAIHVPMKDLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRV6</accession>
    <name>A0A084VRV6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein elav</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Embryonic lethal abnormal visual protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRV6"/>
    <dbReference type="STRING" id="74873.A0A084VRV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008320-RA">
        <property type="protein sequence ID" value="ASIC008320-PA"/>
        <property type="gene ID" value="ASIC008320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008320"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010424"/>
    <dbReference type="OMA" id="NAEMADH"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000480">
        <property type="entry name" value="Fne, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000510">
        <property type="entry name" value="protein elav isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="149"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="378" mass="40490" checksum="E80D8EBACD317645" modified="2014-10-29" version="1">MTNKVLAAVQDLQKQQQAQQQNGGGGGGGGGGGGEAGQAAGAAGGAGQSSENSSRTNLIVNYLPQTMTEEEIRSLFSSVGEVESVKLVRDKNVIYPGQPKGQSLGYGFVNYHRPQDAEQAVNVLNGLRLQNKVLKVSFARPSSEGIKGANLYISGLPKTITQEELETIFRPYGEIITSRVLIQEGNDKPKGVGFIRFDQRKEAERAIQALNGTTPKGLTDPITVKFSNTPGQNAAAKVVQPALPAFLNPQLTRRLGAIHHPINKGLARFSPMGGEVLDMMLPAAPTNGLNVAPSGGWSIFIYNLAPETEENTLWQLFGPFGAVQNVKVIKDAATNQCKGYGFVTMTNYEEAMLAIRSLNGYTLGQRVLQVSFKTNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSE2</accession>
    <name>A0A084VSE2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00008414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSE2"/>
    <dbReference type="STRING" id="74873.A0A084VSE2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008414-RA">
        <property type="protein sequence ID" value="ASIC008414-PA"/>
        <property type="gene ID" value="ASIC008414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008414"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014904"/>
    <dbReference type="OMA" id="HTHMAAK"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="140"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB40886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="38954" checksum="A021AEF83A9E8001" modified="2014-10-29" version="1">MASFVAASRAALKFLQLPSSGFLAPCLQNAAILNQQQVRHRRTKHWDPKWKRLRKAKVIKIDIPNLNEKAEDLSQEQMKTRMKERGIMPPRPWLERPFYISCTGGVFEPYVPPEGDGRMSLVSREGAKQKIEQLEKKTKSMMAIRKIRSYDEDFEPPEFATLAQDLYIQAHRTLCEKNKYKLREIVTERAYPELMHNVADKTIHWQFLKSLEPPRVVHARCTDVITKENIFAQVTVRFHSQQTLAIYDRFGRLMHGSETLAKDCLEYVVFEKHLANEYGVWRLHEKIVPDWMPPKAPAFITYRVDDEPPAPVETVAEETKEAVPANESPKTEVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU58</accession>
    <name>A0A084VU58_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00009103</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525099">
        <property type="protein sequence ID" value="KFB41502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU58"/>
    <dbReference type="STRING" id="74873.A0A084VU58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009103-RA">
        <property type="protein sequence ID" value="ASIC009103-PA"/>
        <property type="gene ID" value="ASIC009103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009103"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022173"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_eS8"/>
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        <property type="entry name" value="Ribosomal_eS8_CS"/>
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        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
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        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOMAL_S8E"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB41502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009103-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="25264" checksum="76F8AEDDAB1DB83B" modified="2014-10-29" version="1">MVAATIGTCGPAVNQIVLASSQCRDSYHKRRATGGKKAAIRKKRKYELGRPAANTKIGGTRVHFVRTRGGNRKFRALRLDSGNFAWASEGMARKSRIIDVVYNASNNELVRTKTLVKNAIIVIDAAPFRQWYESHYLLPLGKKRDLKAGEEDVIAKQRSKRTMRKYLKRQKTAKIDAALEEQFNAGRLLAAIASRPGQSGRADGYILEGKELEFYLKKIKNKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUN3</accession>
    <name>A0A084VUN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010467-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009305</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUN3"/>
    <dbReference type="STRING" id="74873.A0A084VUN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009305-RA">
        <property type="protein sequence ID" value="ASIC009305-PA"/>
        <property type="gene ID" value="ASIC009305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009305"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017796"/>
    <dbReference type="OMA" id="RGECREP"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
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        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783900" evidence="6">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009305-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="270" mass="29227" checksum="037C19258C72585A" modified="2014-10-29" version="1">MYRIIFISVVVAVFAWLPLAQGVTNPCEGRPDGVFRFFTCFRGEAIRGTCPDGFVFNEEQQICDHPWNVKCLICPEESATSPTPVLVPIEGECSFYTLCFQGIGTLRECAEGLLFDAEQSLCDFAENVDCEIGVCPSNLNPTIPTFLPNPTDCSRYFICIGGEAQEAQCAPTLLFNPETRRCELEETVECIEGSIPSPTTCPPTGLHIIGNPADCVSYFVCLNGVQSDAPVNCAPGLIFDVTESLCNIPNEASRCADGSNPNPVPVPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV82</accession>
    <name>A0A084VV82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009721</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009721-RA">
        <property type="protein sequence ID" value="ASIC009721-PA"/>
        <property type="gene ID" value="ASIC009721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009721"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019487"/>
    <dbReference type="OMA" id="PESAPHY"/>
    <dbReference type="OrthoDB" id="5975336at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="574" mass="61888" checksum="B0D85903E1166BCE" modified="2014-10-29" version="1">MTVAETYENQAHYDITFLMFVWIAFLPTIIVPWIYASWVLSKPTKERLRGYLRLSSRRNTGTRSEQSLDEPGSTPPGQASKKALPLATPMPSIGPTANATNTVDNSGSSHRRSTSGRSGRGPILSADRLHLQADATATTSMMHDDSKSPASNSARTVETTISRQSSMAGRPRRQLPPPLRIEESNFHRTPSVQSGRTPSSGVNGAAHNSSIRSTASRVSSTAPLYRRYSRSQPQQPSMPDDDVGDDVSSLVGNSSDVTSSTYCVLPESAPHYANDPLSVAPGHRHLSGSSATYRRRSSAQTQASHLSAQSHATSASSVSRGRRGSAGTEDREATDELLADDDVSEIFSSVSQPSARKPVGILKATPSIASISESEYSSRKGSFSTLSRDLEIIDQLERERSMDIQEMIQREKSYEQYLVRQNSKLKFSTNFDEYFESAAVREAAAAAAAMASGGAGEGSPQPSHQGGSAQLPLQPIQSVGTVAQLPTPASRGGSLSPHSRARSPMHRRSSQLSGPPVSAGYAGEMGVGERQQAAFGPRRSIELERRFHRTYSTSGSTRSGSTRSRDRITFQDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW05</accession>
    <name>A0A084VW05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP013221-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009813</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW05"/>
    <dbReference type="STRING" id="74873.A0A084VW05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009813-RA">
        <property type="protein sequence ID" value="ASIC009813-PA"/>
        <property type="gene ID" value="ASIC009813"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009813"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004375"/>
    <dbReference type="OMA" id="FCEYSIR"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="92"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009813-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="346" mass="38146" checksum="9919DCA46047F72F" modified="2014-10-29" version="1">MEGISPHPLVILFQDSTVVGKMFLRKSRSFSTVILVIAVFLCSAVAGKRISELKCDKYKEIISIRGAVLNTSSKPTVVYFEGKNCSNLIDLISGGKEAMYGEFPHHAILGYRQDDGSYSFKCGGSLISDQFILTAAHCFKFEYPTLVRLGEYDLAVNSSNKVDLGIKKIIRHPNNVHVKAYHDIALIQLNETVRFSKFIRPACLWTEPVLNTTSFIATGFGMLDNYALQYSTHLMKVKLDLFPSKDCQRIYATLSKHSYGISDGQLCVGSIVGGKDTCQGDSGGPLQIITEPGSCIYNIVGVTSTGLACGIGNAKAIYTNVAHYLDWIEQTVWPENVVNKTDWNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXL9</accession>
    <name>A0A084VXL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005296-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010453</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXL9"/>
    <dbReference type="STRING" id="74873.A0A084VXL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010453-RA">
        <property type="protein sequence ID" value="ASIC010453-PA"/>
        <property type="gene ID" value="ASIC010453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010453"/>
    <dbReference type="OMA" id="HKNIGEE"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="311"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="404" mass="45713" checksum="534A7EDFB49E483E" modified="2014-10-29" version="1">MAVALRIFNFPPIFTNVDVREFLNLFGLQATGVFRRRTCHGAFVNVANEAEARLVISRLHQLLIKSHRIKVEYYERGKESNDEEKSAITDTQVAVKGRTFNEIQEGRPTINYEGFPPPYLLYRYPKHTPLILANICSELASNTPFYYQVLHLMNKMNLKAPFPRLDPDKEASTSGPVQPNANQATSEDESELESDDETNERKKVKLNHLKPTMKVLNYDKLQPKFQDVGKQPNKKPNIEIHISGESLTTTQSVCSAKSIATIAEEAKTTNESSPQQTNLISLDDILNNRIPEEQRNGLSVFQNYTPGEPTTKLYIKNLAKSVTEQDLQNVIRVFFEKDSPYEFNVKLMKTGRMKGQAFISFLPVGEVDSSSNDNLKQCVARVLSTINGYILKDKPMVVSYAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXX9</accession>
    <name>A0A084VXX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002521-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC010575-PA"/>
        <property type="gene ID" value="ASIC010575"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS021857"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KR_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="PRK07231.1"/>
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    </dbReference>
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        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010575-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="27173" checksum="F337243AE637A84A" modified="2014-10-29" version="1">MDFTGKVVLITGASSGIGEGTAIYFAKFGASLALTGRNEANLNKVSEACEAVSKNKPLLIIADVTKEEDNKRVVDAIVEKYGKLDVLVNNAGIIGNGSIENTSLQQYDELMNTNVRGVYHLTMLAVPLLVKTKGNIVNLSSVAGNRSFPGILAYSMSKAAIDQFTRCTALELAPKQVRVNAVNPGVIVTDIHKRGGMDEEAYAAFLKKCEQTHALGRPGVPEEVASTIAFLASDGASYITGVTLNVDGGRHAMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXZ0</accession>
    <name>A0A084VXZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP008299-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010641</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXZ0"/>
    <dbReference type="STRING" id="74873.A0A084VXZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010641-RA">
        <property type="protein sequence ID" value="ASIC010641-PA"/>
        <property type="gene ID" value="ASIC010641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010641"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010194"/>
    <dbReference type="OMA" id="IRILAHH"/>
    <dbReference type="OrthoDB" id="21522at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356:SF1">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="374" mass="42182" checksum="5A8006020C996EEE" modified="2014-10-29" version="1">MDVDQRPLVEQIRNQKRNELKLDQKSHRKKELDRNRAGLGELHHSIGIIEHIPEQEVKALAGRIKRRKRCEPLDLVRLSYGFQQSRENISHFIRITGAINVIVKELTGNDYNLQLLAAECLCNLSLGDDVCCEKIASFSGAYLIALSENPNFRPLQQTCLWTLQNIVASSPKGTKVLFSQGLVVVMIRLLASVTDQEAADDIILTLELALNYEQETEATLARIVKCFVGRVLQPSSLRLLHKCYNLMPTDQLLHESSVDIIHSCLNFLSSVTGTHLQPQAAPILLSIRILAHHVVASQQYVAEIFRHLVQQQQQAVKFSVLFNGCAAEEMLPVCKELLWFLGQLHTDGSSNEGMRIYLSYDNFVEHLSVPKALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYM2</accession>
    <name>A0A084VYM2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RB1-inducible coiled-coil protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">FAK family kinase-interacting protein of 200 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">ZHAS_00010746</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYM2"/>
    <dbReference type="STRING" id="74873.A0A084VYM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010746-RA">
        <property type="protein sequence ID" value="ASIC010746-PA"/>
        <property type="gene ID" value="ASIC010746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010746"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004623"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018295"/>
    <dbReference type="OMA" id="IHLAPQM"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17060">
        <property type="entry name" value="Ubl_RB1CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000049">
        <property type="entry name" value="RB1-inducible coiled-coil protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="21">
        <location>
            <begin position="117"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="22">
        <location>
            <begin position="976"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="216"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="621"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1100"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1192"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="727"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="854"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="907"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
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        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
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        <location>
            <begin position="1151"/>
            <end position="1163"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004371"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
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            <dbReference type="ARBA" id="ARBA00053494"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069790"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080154"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KFB43066.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141038" checksum="BD2EE49F9BE141ED" modified="2014-10-29" version="1">MMYVFHVDQGRMLTFEMNWMFEDIRKLKEVIERNHAIPANSIVLLVSGGELLEDHTRVCKYATGTDTNPIYMFSTKLGDSPLPSPGPSKETEVDLEGLVKKSLELPVCYPTVVSRAQLAQKICEMGREELRRCEALVHEQHLQQQGWAAVVANMEDTVKEFQERCEDFSRFYEEQIRLHEEQMDILNNFDKNLQQLADIPILSTLMENTELRPYGMFDEPFNQNGNSSGHSAQRATTSGSSERPGLKAIEEGSGDAAESGQGEHDSSKPTEPSATGDAQTVEGTSNSADPSEVTAAADVVLTEVERAKGISLLDWISAAEGQLTLKRMAEECRIGMEKFSRQQLTGLKDRIQKAVKTSQSDDIRIVKGLEERLCGLDQLLAEAKKIVQEQTELAQSIQMNQTRANTLGDTSILPDLCSMHRNHLKLMKDNHTKMLEYRRRCQAAKIELGKHLTRRLDYIMGLETMVCDLDSHLLFCYTSLKRLQKHLSIIEQIHMAPCMYVSAVTEVVRRRMFSSSFLRWASDLACRLMTIHNEEVMRRQEFTSQFEGHFLSTLFPGMNDMPPSYAIQAPSVFDSSLPALDKQDLRELSRFLPELTEKIPLPNIASVIDFFQTRSVEQKQQTSSCNTGREEASASAPDQQCAKDSDKVGAESETDTEEFENVQNQTQGRSSDEGTAGPAAAAVLMCSVATSTEPVETVSAETLTEAVARNRERETIQRLTVDHELEMNDLRKSIHQKDDEIQSLRADNSTMKASQIETVSSYEQEKRELADQIEQMKAVIGRLERQLAESEVDRKRAIQEAVEQLEHKHRTEIETLRCRFKLMATSMDRSPSDTSLEKIERPDMIDTGTHEQVLAQLREEFAREKERAIRAAVEEERQRWEANATPGGGGNRLHRSFASAGSPGGSQDVYKRILEEKDRQLEEAREKEALLARENQRMKETIQSLTDPELSLNDLNYREQLETLEGDRQQLAEQLATQQSNVERLQGEKKSLARELTKQRRDSAQLLTCSEGDTVTFVWNPTYAQYTIVQASEFHFFLHEGCYAELGLQPLVMGEVPTVLSGVGTVVHKEFCHARKNDNRYRVSRGTHFYRVKLKPVNLHKKSKGGSSSTSGKTIPTIVENPSIPQPSPTVVTIEMQQSRSSGGGGGGGTTTTVGSTGGTNTTSRFLDSFAQTEQPASLVAPSTRATTMMIGSPIDDGSKSPTGSTASRDMIDSGVVEQQRSSYRERNISITDEEDIAGPPVGIGSDGSIDRIRYQSLLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ09</accession>
    <name>A0A084VZ09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010981</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010981-RA">
        <property type="protein sequence ID" value="ASIC010981-PA"/>
        <property type="gene ID" value="ASIC010981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010981"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8553" checksum="587C856912867071" modified="2014-10-29" version="1">MEIFAGPLQCAGPPFVPLANSSHFGGEVTDSDSTRAGMCPAPTFPQSPLLRSVLHGGLTKYIRIPQHDERMDDIPDFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ99</accession>
    <name>A0A084VZ99_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00011078</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01018619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ99"/>
    <dbReference type="STRING" id="74873.A0A084VZ99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011078-RA">
        <property type="protein sequence ID" value="ASIC011078-PA"/>
        <property type="gene ID" value="ASIC011078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011078"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011040"/>
    <dbReference type="OMA" id="YRCFFAS"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF61">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="367"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="506" mass="57612" checksum="AA7535E9E0FFA12E" modified="2014-10-29" version="1">MDVDLNDGRDRIAPMFKDRHVLITGGTGFLGKALIEKLLRCCPEIGKIYLLVRAKKGKSPRQRLEDIFANPLFETVKGLRGLDTLISQCVVIGGDVTEPELAIAPEDRKLIAENVSIIYHCAATIRFDETLKKAVMLNTRGTKFMIDLAKQCKKLDMFGYVSTSYCHLNEKLLLEKPYPPPADPHKVIKAVEWLEEGVVDGMTAKILGDCPNTYAYTKALAEALVVESMSEIPAVIFRPSIVIPTWREPIPGWTDNINGPVGLLIGAGKGVIRSMYCNSTGYGDYLPVDFAVSAMCVCTWNYVGNKDFKRNIYHLVSSAEIKVSWEGIIERGKWIVSNKIPLNGVLWYPGGSMKRTRWEHNLAALFFHWIPAFFIDCLLYCFGYKPILWRIHQRIAKGFEVFEYYANNQWDFDNASVLYLRTIINDEEKVKFKIDAGGVEIQEYFENCIRAARWYILKETDDTIPAAKRHMRIMWWVDKICKTLIYGGLIYYIGKALYSLLFASVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZB9</accession>
    <name>A0A084VZB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011111</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525247">
        <property type="protein sequence ID" value="KFB43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011111-RA">
        <property type="protein sequence ID" value="ASIC011111-PA"/>
        <property type="gene ID" value="ASIC011111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011111"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7595" checksum="C56C7A4E53EB5F66" modified="2014-10-29" version="1">MVGYLNRVGVSWRNKPSAFTPKTRKPKTNEAWLANGIFWPAGFGSVLMGAAIEGSGQPDTNLLISGSTARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZC2</accession>
    <name>A0A084VZC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP003400-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00011115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018733">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZC2"/>
    <dbReference type="STRING" id="74873.A0A084VZC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011115-RA">
        <property type="protein sequence ID" value="ASIC011115-PA"/>
        <property type="gene ID" value="ASIC011115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011115"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004040"/>
    <dbReference type="OMA" id="GFCPCKV"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16232">
        <property type="entry name" value="EFh_SPARC_TICN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000246">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="5" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="13">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="465"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="498"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="563" mass="62412" checksum="01201373CC67D96D" modified="2014-10-29" version="1">MDSAAALQLKQDQQQMIPEKKKWIHDPSSDLCKPLNCKKKELCLLEDAYTAVCVSKKELHKNKEEIITKSKYFEQEEAKRKAEVDAEAAAAAAAAAASSSSSSSSVAAGSNINANNGMGGGTPDGGASMTLMAASGDSSTGSNGNDGTSSGLEQEEREDDESSSQDDDVFYDSEGGEKEEDCKPCPVVKPTFLCGSDNRTYSSLCRLEYHNCIHVSEVKVSCKGFCPCKGKRKGGEKQANNLLQDLRKQQRMAERMSAFNAKYQRTIDSNDINADNLIPSEKVSGRKGDGKERTRKRTDTTTTSTRSTHSRRRRSSTTTSTTSTLSTRRTRASLINRPLRFSPPTRSGKTGYAMKSSECKPQQLTAIGNRLLDWFSVIMADSKKRRQHQQQKNKVHFPAACKLEARWMFGHLDLNNDGELSTQELYDLEHDQNERCIKPFIDTCDLDQDGTIDPREWCRCFEKTDRPCAAVRRRLGNDLSGSYAPDCDSQGFYKPTQCHQAVGVCWCVDEHGVEFANTRTRGKPNCEEIINNATTLNSDDEDTEDSDDDDDSQEGSADRLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZP5</accession>
    <name>A0A084VZP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011245</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525254">
        <property type="protein sequence ID" value="KFB43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011245-RA">
        <property type="protein sequence ID" value="ASIC011245-PA"/>
        <property type="gene ID" value="ASIC011245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011245"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7430" checksum="AFF2A8D99B3393A6" modified="2014-10-29" version="1">MPRSTITVSNLAKRTPDVAHLRDLPKGLLGDLPAKRNVMQRHPRGSACEHDRSIRRSHPIIAAGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZT2</accession>
    <name>A0A084VZT2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00011279</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="11">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01018955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZT2"/>
    <dbReference type="STRING" id="74873.A0A084VZT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011279-RA">
        <property type="protein sequence ID" value="ASIC011279-PA"/>
        <property type="gene ID" value="ASIC011279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011279"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017285"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="359"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB43476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011279-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="446" mass="48668" checksum="65367206F9E56BF8" modified="2014-10-29" version="1">MAAILRRSSLLLADIASKSSPKVLASGSQRRHLNVQEHVSYSFLNEAGIPTPRFGVATSGSEAEKIAADLKTKNLVLKAQVLAGGRGKGSFKNGLKGGVRVVFSPQEAKEISSKMINQLLVTKQTGAAGRICNSVMVAERKFPRREFYFAVMMERAFNGPVLIASSQGGVNIEEVAAENPDAIVYEPIDINKGLQKDQAIQVAKKVGLQDKLEETAKMLLNMYDLFVKKDALLIEINPYAEDAAETYFALDAKMRFDDNAEFRQKELFAKRDLTQEDKKEVEASKFDLNYIALDGSIGCLVNGAGLAMATMDIIKLHGGDPANFLDVGGGASVKAVKEAFKIITSDPKVHAILVNIFGGIMRCDVIAEGIIQATKELNIKMPIIVRLQGTNVNEAKELIKKSKLRILPKDDLDEAAMLSVHLAQIVHLAREAHLDVSFELPDTYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2B9</accession>
    <name>A0A084W2B9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00012303</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01019596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2B9"/>
    <dbReference type="STRING" id="74873.A0A084W2B9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012303-RA">
        <property type="protein sequence ID" value="ASIC012303-PA"/>
        <property type="gene ID" value="ASIC012303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012303"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001417"/>
    <dbReference type="OMA" id="WIFYHRI"/>
    <dbReference type="OrthoDB" id="7733414at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="158" mass="17951" checksum="F1FB6F4ABEEA0A32" modified="2014-10-29" version="1">MLTRGTICQRFPSLSPDHADHGDHVDPSVLKRLHGTFMVIAWLFFNSLGNTVARYFKKTWTNRQYFGMPLWIFYHRIYMVACWTLTTASIICIIVDLETIKGHAHAIIGLTTFVLVFIQPILGMAGSGQQQQRPMAILRILHVLIGHTAYILAGKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3A1</accession>
    <name>A0A084W3A1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008185-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00012612</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525284">
        <property type="protein sequence ID" value="KFB44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3A1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012612-RA">
        <property type="protein sequence ID" value="ASIC012612-PA"/>
        <property type="gene ID" value="ASIC012612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012612"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005239"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000023">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="93"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="441" mass="49220" checksum="85949852DC2EC07E" modified="2014-10-29" version="1">MNQLAPHQSQKCNQRISGSRWQQTNQYGEQQRRNVIVGCTTSAQQKKATSAKMCRRVEITVRTLLSAIVVLHLLPYALVGYTLAKTAQPKQSCDKTRRVFTQSHGEISDGPSGSNYTQDSHCEWLIRAANDSQFITLKFRSMGTECSYDYIFIYDGDSFRSPLLGSFSGNTEPQHVVASSGSMLILLYSDTNYVLEGFRAEFFVTNCPNNCTGNGRCADHVCVCDGGWMGSDCSLEVCPFRCGEDEGRGKCRNDRCECSMDYVGQSCSLHRSNPVPKEWHWLSNSRNGLPPRAAHTAVYHEPSDSLYVFGGYNLNEVLDSLYVYRFAKNHWEDEWGLRVEHNHTEAPGSEAEEKALRRAMFLEVETERLGLAKEPNFLSNVIYTLADNRTDVDGFNGNGTRPAARYGHAAATVPTVSCCSVVNLPPASRRXXXXXXXSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3F6</accession>
    <name>A0A084W3F6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP004386-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012651</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3F6"/>
    <dbReference type="STRING" id="74873.A0A084W3F6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012651-RA">
        <property type="protein sequence ID" value="ASIC012651-PA"/>
        <property type="gene ID" value="ASIC012651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012651"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021599"/>
    <dbReference type="OMA" id="HVWALET"/>
    <dbReference type="OrthoDB" id="10055449at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11466">
        <property type="entry name" value="bHLH_TS_HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF68">
        <property type="entry name" value="FI14601P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784473" evidence="7">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="38362" checksum="61101AB298F99355" modified="2014-10-29" version="1">MAFFRFFLFSLAAGGTPVNGHGGHGILLDEEGYWGSPCSSSESQPDPTHRDRYSTPPPPQPLPSAAMTQTTLGLAGSTGGGVLVRPGLRHIPAASIQPADQSSSYSSVASCSSSSSSSSSSASPSTSSSPYGGHPNAGYHHQPRHLAHDGQHQPHQHQHHHQHQQTPPSMVQYMVYDKGTAYIPDEGYYGGGNGTSLDIVSGTGGEDHSAHLQVTQSSSGVIPGNGLPVVRVVKRRNTANKKERRRTQSINSAYSSLRDRIPNVPNDTKLSKIKTLRLAISYIAHLLAVVNGNQDPSCDFRAELVPSSRKINAERRAQKTLMQNLSTNGDVSSGARKVKGRTGWPQHVWALETKTTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3G4</accession>
    <name>A0A084W3G4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="5 19">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00012674</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="5 19"/>
    <dbReference type="EMBL" id="ATLV01019997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525289">
        <property type="protein sequence ID" value="KFB44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3G4"/>
    <dbReference type="STRING" id="74873.A0A084W3G4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012674-RA">
        <property type="protein sequence ID" value="ASIC012674-PA"/>
        <property type="gene ID" value="ASIC012674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012674"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006186"/>
    <dbReference type="OMA" id="TWHTQAR"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF50">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17 19" id="KW-0464">Manganese</keyword>
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    <keyword evidence="8 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="9 19" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759942" description="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
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        <location>
            <position position="343"/>
        </location>
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        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004323"/>
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            <dbReference type="ARBA" id="ARBA00004922"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="402" mass="44406" checksum="351FC2DF3168B70F" modified="2014-10-29" version="1">MLRSYKLYLMLLVSSIFFIVCQNQGSITSFVSNAAAASSPSASASGAADDMPLGVSGALSERLVAMADGELVYGEPVPAPAEKIRSRSLNFKDIPLKLNDRSSSTSAATTSLTTTTTTTTSTTAKTTTSTTTTTTPKSTVDKEAAQQLFPVDTKRLPPLYIITPTYRRPEQIPEMTRLGYTLKHVPNVLWIVVEDSENRTDAVTRLLEDIGVPYVQLAAPMPAQYRKQKVKPRGVSNRNRALQWIRANATEGILYFADDDNTYNLKLFEQLRHVRKVAMFPVGLISKYQVSSPIVKNGTITGFYDGWLGGRKYPLDMAGFAVSVKFLHSRPKAQMPFKPGYEEDGFLRSLEPLDLKEVELLASNCTEILTWHTQARKNPPAPALDRKKYGGTNLVQLTSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3K8</accession>
    <name>A0A084W3K8_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Hypoxia inducible factor 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012710</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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    </organism>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020057">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB44802.1"/>
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        <property type="protein sequence ID" value="ASIC012710-PA"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012710-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="195" mass="21209" checksum="7DEBEF5009F9BB33" modified="2014-10-29" version="1">MAATRHPVGRRKHSSFERNTPQQATAAPIRCSPSSTMVVSSTYPTCETNPQQAGRQHNAFVAIPSPLDGRGEAGDAGGCDEGSEIRAPIPTTAPWAKHNPPPGGREPARAIQRRRQRRFRKSGSIRERKTTTTLPSASANQPPIRFLRAMRDFQKASKAAPVVRLQVSLASLATRLFASTTDSLHQRRRPGSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3R5</accession>
    <name>A0A084W3R5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00012769</name>
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    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525294">
        <property type="protein sequence ID" value="KFB44859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3R5"/>
    <dbReference type="STRING" id="74873.A0A084W3R5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012769-RA">
        <property type="protein sequence ID" value="ASIC012769-PA"/>
        <property type="gene ID" value="ASIC012769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012769"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007098"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022882"/>
    <dbReference type="OMA" id="VPCGQIF"/>
    <dbReference type="OrthoDB" id="7733922at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001579">
        <property type="entry name" value="Crooked legs, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000253">
        <property type="entry name" value="Crooked legs, isoform H"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000151">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB44859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012769-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="734" mass="85456" checksum="2C7950AF189A6ACF" modified="2014-10-29" version="1">MVSSKRSSHLTNLSGPAATHSSRGSTGHLPPPPGSHLQVHPAHSGSGGHHPPPPPTQGPPQSAHPPPPQPIPIVKPEFKVPPLPGHIMDVRGPDGSIVKINMPEHHDPSKPPNNVEMLKVNIEDLSQFLSYHEVFGKLPSDMLTGPSASLVPSSSTNTATTSAHSNVNHIRHPTGESPFKCSYCAKSFTRKEHLTNHVRQHTGESPYRCPYCGKTFTRKEHLTNHVRLHTGETPFQCSYCQKKFTRKEHLTYHVRLHTGETPYQCTYCDKKFTRKEHLTNHVRIHTGETPYRCTYCEKKFTRKERLTYHIRWHTGETPYHCTYCEKKFARKEHLTNHVRLHTGETPYQCTYCEKKFTRKEHLTNHVRLHTGETPYPCTYCEKKFTRKEHLTNHVRLHTGETPYQCTYCDKKFTRKEHLTNHTRLHTGETPYHCTYCEKKFMRKEHLKNHIRLHTGETPYQCTYCQKKFTRKEHLTNHTRLHTGETPYQCSYCQKKFTRKEHLTNHVRLHTGETPFQCTYCQKKFTRKEHLTNHTRLHTGETPYHCTYCEKKFMRKEHLTNHIRLHTGDSPHKCEYCNKTFTRKEHLNNHMRQHSGDNPHCCNVCNKTFTRKEHLINHMSRSHTGERPFQCDECGKSFPLKGNLLFHQRSHTKGQPMDRPFRCDMCPKDFICKGHLVSHQRSHTGEKNHHCPQCSKSYVERGNMLRHMKKTHPDAVIPVLPKLPHIKVEPKSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4S0</accession>
    <name>A0A084W4S0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP008244-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020377">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC013180-PA"/>
        <property type="gene ID" value="ASIC013180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013180"/>
    <dbReference type="OMA" id="QVECEIT"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383:SF1">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784481" evidence="2">
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            <begin position="24"/>
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        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
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    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="636"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="651" mass="69804" checksum="BB98F96AACC59FE7" modified="2014-10-29" version="1">MSSNKVLVCLVVLQFAWMIGATSFECPNADFDGGRRAARIYALPHSCTGYVTCVGKIKIEAQCPDGSVWSDQVKSCVRTDGTDVKCVVHEHERTRRDTMIETVSVCAASCPQFFDPRYLVLIPHTNCNRYNLCVLGLMLTVSCPNDLRFNQEKCACDFKENVYCEGDELTTVTEVPSESTTLESTTEAVTKEASESNTEESTTESSTESTTEEPTTESSTESTTAEPTTESSTESTTAEPTTESSTEEPTTETSTESTTEEPTTESTTEEPITETSTDSTTVTEEVSEPTTEESTTESSTESTTEEPITETSTESTTEEPTSETSTDSTTVTEEVSESTTEESTTESSTESTNEEPTTETSTESTTEEPTSETSTDSTTVTEEVSESTTEESTTKSSTESITGETTTESTSEEPTAESSTESTTVTEEVSESTTEETTTETSTESTTEESTTESSTESTTEEPITETSTDSTTEEPTTETSTEEPTSETSTESTTVTEEVSESTTEESTTESSTESTNEEPTTETSTESTTEEPTSETSTDSTTVTEEVSESTTEESTTESSTESTTGRAEVSESNTDEYPTTTIAPATSSTERIPVTGMGIFGLKTSNQCRVPVDEEDDDATEQVEEDILPSPQSSVALTSSTSSSLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W544</accession>
    <name>A0A084W544_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00013287</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01020480">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W544"/>
    <dbReference type="STRING" id="74873.A0A084W544"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013287-RA">
        <property type="protein sequence ID" value="ASIC013287-PA"/>
        <property type="gene ID" value="ASIC013287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013287"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011234"/>
    <dbReference type="OMA" id="YHAVWGS"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB45338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="305" mass="33798" checksum="15C93416B629E58B" modified="2014-10-29" version="1">MAYQVTQLPSPLAKLGEGPVWDIDTQSLYYVDILTPTILRYDYKENRTYNATLDGAATISFIVLVTGKPEHFVIGENNRVSLIQWDGRSEKASPVRTLADLGESHCNVRFNDGKVDPLGRLYAGTMLWESGGDPNIQKEGQFYRYDNGTMVSLKRNVSISNGLTWDEPTNPLRMYYIDSPTLEVKAFDVDGQGDLKNETVFFDLRVNGTAPGYVPDGMTSDADGNLYVATWGGWQVLKVDKTTQKVSQEFKLPAERITSVAFGGPQLDELFVTSAFHVDKPAPAGALFKITGMGVKGKPMYKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5M9</accession>
    <name>A0A084W5M9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dsec\GM15616-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5M9"/>
    <dbReference type="STRING" id="74873.A0A084W5M9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013467-RA">
        <property type="protein sequence ID" value="ASIC013467-PA"/>
        <property type="gene ID" value="ASIC013467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013467"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021425"/>
    <dbReference type="OMA" id="DQALVHI"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000051">
        <property type="entry name" value="F-box and leucine-rich repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000059">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="378"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="494" mass="54223" checksum="0970BD22363D9329" modified="2014-10-29" version="1">MEEASFMLTEIPGGFISHRPHTIGGGHHHRFAPYPVVLHQPHLQQTSASPAIYSIPAHHLSHHVHPHHAHAGHHGAHHAHAVRSANRPRSPATPPTQPVEEGTTIGHLYPEILAIIFAKLSVRDRGRAAQVCTVWRDAAYAKSCWRGVEASLHLRRPSPTLFGSLVKRGIKHVQVLSVRRALKDIVTGVPNLESLNLSGCYNITDVAIGHAFAVDLPNLRELNLSLCKQVTDSSLGRITQHLKNIEVLELGGCSNITNTGLLLISWGLKKLRRLNLRSCWHISDHGIGHLAGLSKETADGTPALEYLGLQDCQRLSDEALRHIAQGLTSLRSINLSFCVSVTDSGLKHLARMSRLEELNLRACDNISDIGMAYLTDGCSSISTLDVSFCDKVADQAMVHISQGLFQLRSLSLSACQITDEGLSRIAKSLHDLETLNIGQCSRITDRGLETVAEELQNLRAIDLYGCTRLTSAALERINKLPRLSKVNLGLWHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5U5</accession>
    <name>A0A084W5U5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000323-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020694">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5U5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013577-RA">
        <property type="protein sequence ID" value="ASIC013577-PA"/>
        <property type="gene ID" value="ASIC013577"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013577"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004233"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004333"/>
    <dbReference type="OMA" id="QIEKNHD"/>
    <dbReference type="OrthoDB" id="2436455at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013577-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1748" mass="203593" checksum="71A3D538C12123C1" modified="2014-10-29" version="1">MAEAQHTNQTNEDWRRVVLEWVKCSNLHNATDTIRLGVVFDAFRKRILETNQLRETNIIEFLRVHFPHFELNECDEIPECDNVYVFSLMLYFSCVRLPIEYFQNVCKTFSDDHQRSVKTFLDSFLTNLNQKKPIDRCFLDTAFSKATNSTRRKLEQHPEPKRGSSNGAQIFSSTPANKMENKIPSPQTPKNISLEWKMRNLQNLLDSARSENGTLEKQNEQLVQRIQELNEDKQRLMMKIKALQLTEERCETHSNERLDDNDHQHELCRKKLEKHNELIELLHEEISKAKENACIDMEQLSAVKTNNIQLKRDIQCLESTIETLNKELSRQGDINESQAEVINDLRRFIRESRLTCSESLAEPLESSFNCFDSFSELSLLNESRGLEPENLASTVVEVKLREQEIENEELTKQIEKHMLDMKQHKEDRNREIADFNAKLLELQRDNAEMNAMVEEMQKSLSETVERKKQLEQALEKQEEDHKSAQTEMIAKVEELKKSLVEKDENIEQLEKKLEDHKCAQMELNVKVAKLQKLFEETVEKKKQLEQALEKQEEDQKCAKTEMNAMVEELQQLLAETVEKKKQLEQALEKQEKEYKCAQMEMNVKVAELQKLLVESDVNIKQLENQLEDHKCAQTEMNAKVAELQKSLVETVETKKQLEHALTTQEEDHKRAQMEKYAEVAELKHLLEESVETKKQLEQALEKQKEDYKRTDMEMNTKVAELHKLLAEMVESKKQLEDALEKQEEDQKCAKMETNVTLAELQKSLVEKDVNIKQLENQPEDHKCSQTEMDAKVAELQKSLLDTIENKKQLELKLKKHEEDHNCAQTELIFKISELQKSLAETVESKKQLDLALAKQEEDHKRAQMEMDTKFAELQKSLEESVEIKKELEQALAKQDEEHKRADMVLNAKISELQKSLAETVENKKQLEEVLAKQEEDHKRVQTEMNVKVAELQNKKDENFKQLEEQLEDHKRVQTEMNTKVADLQKSLAETVESKKHLEQTLEKQQEDHKRVQLEMDTKVAELKKSLEESVETKKQLEQTLEKQKEDYKRADMEMNAKVSELHKSLSETVESKKQLEQTLEREEEDHNRVQTEMNTKVADLQKSLEESVETKKQLEQAVAKQEEDHKRADMELNAKISELQKSLAETVESKKQLEQAVAKQEEDHKRIQLEMDTKVAELQKSLEESVETKKQLEQAVAKQEEDHKRTQLEMDTKVADLQKSLEESVETKKQLEQAVANQEEDHKRADMEMIAKVSELQKLLAETVESKKQVEQALEELQDARHCEQEKLNMKTAELQRCLEDAEVTKQQLKDTLEQQYKNVRSLTVQLQTISKEHGEACSKRNELDEKSEELTSQFKMMKNKADDLEAQCIKLLKKVSTQSEEIVSLKEELDKKGAIEQVVEEKDTELRKLHSDCEILAGKLYIARTQLEENREAQEKEVSSALEKLENLKKSYEEQIREARIVTEEKMERMKERMKEIHKEKLVKLERERQERLESLEQSYKERMENLESRCATLQKQVAEMNERDLQSRKENQLLQTKLKTMEEKSERKSLLLPPPAHARLRCNLKMEDEEGEVFNNTYLADLQNGRCTSPTSSDGGFDRFSELMRRNSMRLPHLRTTYTALEPEIEVPADDTRENVSSVFDDSSTGLITRRKVTGITTYKRPGPPTPSKKAGRFSLGGVLPGTNPEIQYKEALQDANVNAGAAEGHGRTGRTKTPGKFKQMLSSSSLLSNFQRDEVTKKPFFPYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5W3</accession>
    <name>A0A084W5W3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013597</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5W3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013597-RA">
        <property type="protein sequence ID" value="ASIC013597-PA"/>
        <property type="gene ID" value="ASIC013597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013597"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002432"/>
    <dbReference type="OrthoDB" id="6630583at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="30354" checksum="2E3A400C1268863D" modified="2014-10-29" version="1">MALVNYTLPFGSIQAPSWASATPLQNQHASAVNNLLYGPAGHQEDDQDFYKNAPYAPPQRQAKQSPQQQQQQQQTPQHQQQHSIQYRQTPRNNYLPPPAPYIPPSASYPQAPPQPPQVQQPPSAGRTYGEGSYSDGAGAAGSPSSKPPQPPSQQPQQPQQPQQPAYYEYSSGSYATQPGRAFEQAANPQQGTSYRSNTQPGGQPGAPRGSPSQGAAPSYPQRPPSYANVGTVGTHTQIHPVLDYDDEDDDEYYDDPEEVVATVGGISEYQEWDNRTEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5Y4</accession>
    <name>A0A084W5Y4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucose-6-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00013620</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-6-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.9" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01020706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5Y4"/>
    <dbReference type="STRING" id="74873.A0A084W5Y4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013620-RA">
        <property type="protein sequence ID" value="ASIC013620-PA"/>
        <property type="gene ID" value="ASIC013620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013620"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010187"/>
    <dbReference type="OMA" id="ELHINEW"/>
    <dbReference type="OrthoDB" id="6416209at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004346">
        <property type="term" value="F:glucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591:SF0">
        <property type="entry name" value="FI19814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="60"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB45628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="347" mass="40229" checksum="B4765265E02A7883" modified="2014-10-29" version="1">MKLFDSLLRVEIYQILYVQDVFSRYEEFLAGVTRAFDPKILFLTVIPLVAGLSTTLYSKLLLSVLLTEYANTFAKWVLAEDRPFWWLNETKEFTSLNRPKIYQNELTCEPSPGNPSGHLMTSTTYLFVIFSVLEEYLRKYGRFPIVMLRIAYYSTLFFISVSRMYFGCHFLHQCIFGVILGIGMSKVCLSHRLEKYIVKQTGRKRVGFVVLICLVLLGLYWIQKLMGIDPQWAVKMAFKWCEDPFYLKPTTTLVFSIIRLTGALLAFAIVGPVQKAKPLNMKLSIPMVMAMMAFQWIALDNTPRYYGVVIYYLYSLVVNFIFTYGFLRWVPALAGQEIRVSRKSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W618</accession>
    <name>A0A084W618_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">TRAIL receptor2 KILLER/DR5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013520</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020719">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W618"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013520-RA">
        <property type="protein sequence ID" value="ASIC013520-PA"/>
        <property type="gene ID" value="ASIC013520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013520"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10852" checksum="59AFB20E41ECA7F7" modified="2014-10-29" version="1">MESIFTSRTAKPVRARNQSIPSTMLRARKSGGRGSMQSIDAREFLTPGPCNNDREGILQKGRNAIAIDGAVDATICETGKKWQHVVTMAFARRTTITTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W666</accession>
    <name>A0A084W666_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013659</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525306">
        <property type="protein sequence ID" value="KFB45710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W666"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013659-RA">
        <property type="protein sequence ID" value="ASIC013659-PA"/>
        <property type="gene ID" value="ASIC013659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013659"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6420" checksum="C10D403D6B9595C1" modified="2014-10-29" version="1">METLRGAATNRTAAMLSSSMQRSSKKLRDSKQLVVVDSQHQGSRSEALPEGTKNSCTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W679</accession>
    <name>A0A084W679_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013741</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020754">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W679"/>
    <dbReference type="STRING" id="74873.A0A084W679"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013741-RA">
        <property type="protein sequence ID" value="ASIC013741-PA"/>
        <property type="gene ID" value="ASIC013741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013741"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001410"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19670" checksum="90EEF3E1C0AEB1C2" modified="2014-10-29" version="1">MGKLVSRMCNTKELGILMLGLDAAGKTTVLYQLKLSQTIIAAPTVGFNVDTVTFNNVKLNIWDVGGDADTRPLWKHYCSADMHGLIFVIDCTDVDRMHEVRQEFHRIINDSEMRRASILIFANKQDLPNAMKPHEIQAKLGVEILSDRNYYIQPCCATTGEGLFEGLQWLIRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Z9</accession>
    <name>A0A084W6Z9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013959</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Z9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013959-RA">
        <property type="protein sequence ID" value="ASIC013959-PA"/>
        <property type="gene ID" value="ASIC013959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013959"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8106" checksum="5F0BC7AE5C35C6AF" modified="2014-10-29" version="1">MSKNSRRTVAVSEISLFVYVLVCVRRFSIIGIWSIGISINELAGGSTTLGREEHVKLAGKRRVLQRTDGSTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W773</accession>
    <name>A0A084W773_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014039</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC014039-RA">
        <property type="protein sequence ID" value="ASIC014039-PA"/>
        <property type="gene ID" value="ASIC014039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014039"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13913" checksum="73C10D5C4974CD2D" modified="2014-10-29" version="1">MDCLALATVMMRSQRNRFSPDTVDTCRSLIEGLITGPPVEAERPGSKPRVRARWYHFXXXXXXXVQAGFPTANECSFYLYGRSYFNAAKLDPTKYSVRQAGEHVSYMQIKLPSEAAPRDAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8T8</accession>
    <name>A0A084W8T8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021514">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8T8"/>
    <dbReference type="STRING" id="74873.A0A084W8T8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014537-RA">
        <property type="protein sequence ID" value="ASIC014537-PA"/>
        <property type="gene ID" value="ASIC014537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014537"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004548"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000130">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="200"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014537-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="409" mass="46979" checksum="BFB330CE9CC4FAEB" modified="2014-10-29" version="1">MSISVNALRNQLVLLTGSSGIHKEQADKYRSLLEQILLNTGTEMIDTLKLFIEAILNEHVSLVISRQLLSDVSNHLTKLPDDISKSVAHFTLDKVQPRVISFEEQVASIRQHLAQIYERNQNWKEAANVLGGIPLETGQKPYSLDYKLETYLKIARLFLEDEDPVQAEAFINRASILQADTKDEKLQILYKVCYARVLDYRRKFIEAAQRYNELSYRTIVDEDERMMALRKALICTILASAGQQRSRMLATLFKDERCQHLPAYSILEKMYLDRIIRRSELQEFEALLQLHQKASTLDGSSILDRAVFEHNLLSASKLYNNITFEELGALLEIPPPKAERIASQMITEGRMNGYIDQIDGVVHFETREVLPQWDKQIQSLCYQVNGLIEKIGAAEPEWMSKVMEEDMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8U9</accession>
    <name>A0A084W8U9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP009844-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00014549</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8U9"/>
    <dbReference type="STRING" id="74873.A0A084W8U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014549-RA">
        <property type="protein sequence ID" value="ASIC014549-PA"/>
        <property type="gene ID" value="ASIC014549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002590"/>
    <dbReference type="OMA" id="WGETESK"/>
    <dbReference type="OrthoDB" id="9981647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000078">
        <property type="entry name" value="Serine protease H137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="29441" checksum="DC9D6FDAA22C748F" modified="2014-10-29" version="1">MALRIYRGEETQRGEHPWAALLIYGFGRNRTASLCGGTLVSERYVITAAHCVAEQLNRKLLYVRFNEFNTKSKSNCTTDGDENICRYDYEVESVTSHPEYITGGLSNQHDIAFLKLAKDVSFDDYVRPICLPFEAEIQKLPIVNEYFTVTGWGETESKSLSTVQLHVELPGLNIEACNSAYEPSGITVTDRQLCVGGLNGSDSCRGDAGGPLMRQVRGVWYLVGIVSFGARNCGTVDFPGVYTNVIRYLDWIEKVMFVERYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8V3</accession>
    <name>A0A084W8V3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014553</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021517">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W8V3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014553-RA">
        <property type="protein sequence ID" value="ASIC014553-PA"/>
        <property type="gene ID" value="ASIC014553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014553"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011158"/>
    <dbReference type="OMA" id="EIFAHKQ"/>
    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13275">
        <property type="entry name" value="PH_M-RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039597">
        <property type="entry name" value="M-RIP_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2141"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="228"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="778"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014553-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2170" mass="239187" checksum="F92958289C712213" modified="2014-10-29" version="1">MPPSFVDHNYKHHITGENDNASKCLLLDGGAGSEMRARDEPKLKDIANTITNVNRWSSPCITDSLSLTAGADHLEKPSSPRDENTVPPQYTNGGTGGGGGGGGVGTGGNNGGSNGGTGAANGTGGGSVVGTPLQMRPHSLTIPSSAPAIVSAIVKKIPTSAAGAGGKVGQQGQLLHPAASSPKLKPSQTHERGDPDGDCGMDEAPANYLGKNSEHRSGGGGGAEADLLHAKKGWLLKQDVRSGDWSKHWFTLRGAALFYYRDPVAEEKGVLDGVLDVNSITSIAEVPVSKGYGFQLTTWDNHRIILSTMTINIRNNWINVLKNAAGLPPAKPTLSNNNSLELSNQNDDNFKTLHTDKAPPPSTPLASPLELELIAPDVDQKPPQKPPSAKKAKLHEKNNNNLLIEGVVPLAATPGPGEDVVDKALPTMGSCMRGAPVASAPKDVVVHLSARGPSNAIEPTGGGDSNSSSTNSVNSNSSSSSNSSSSSQPQPKSAVQSPVTPLTPKSLLFSSDEEYRTASEGGRRDSVGDWGSPLSPLPPSTMPLGAVLRTKDRLRTSSSSSSSQTAAHRMHKRSRSSPPTSRRSTIDSSVQLEEDDGTLINTTVHESEHEHHHHHHHNTGVTAGLEKELQLRLQAAEKELSMLREETHEREARMSELLTTLERTEQELTRKRELEENREKLMAQLQESRAAGQEIIDRITLELNKSRETTKDLEERLARGIEENESLYRKLRECGIASPSSSMGCLMAIQKRNGAMKRMDSFSDLTCLSEIDPAQLDKDMLADEYRELRARFEKAVSELKAMKRELKDAHGLYDDLEIAYATLQKELDRQVEQHGAQSRMMADRIQDMTNKYTAAEKQVRLLKQKAIRSEKRRSLSLKGKESLSIQKELEEKVSELESKIDALESGGAIVPVVAKEAVELTTPEVVQPSRRSSSSRLRRKSLDSASLSSQPMQVLLRLNNLEKRVDSVHAVTELTPSKRELLECETASTSSSGTTIAPTAGSCASTKLPEHLMDRLKSLEGVVVSVRELIDQSAQQFQNLRSSRSRRSVSPIADKKDSFKFIERCLSEVSKLLRESCDNCIIPDGSSSASGVIVLPDSNPIKLALNQLETQLKNKLADLLKQRRMLRETNGLTQRKDMELLAERIAFESVCFGRLRHALERAENLQEFEERQTKVEVCETIQLMSMLKAKLSGKCVVRPSNSVDVLASVLARKLMLSAGRTSTIRSLTFPPIGTALLDDLLRQQHEVHLIAKRYKTTVMENLAYGLAAETLSYISSSNETVQGAVQEAWRQAQEAVNAELVQSEIAHIMMRNAQRYENSLAPAFGYALSTQERITFETFADAVHEALRREMDAAVGQLTECYEETLEKMKRGQWRLHLEQERKPSEGRQLLAEFADIVAHKALIDARVQVLKGDYVPTKQKLLAQPKGEPSERVFSVAALKQYENLYTDLTADLEVANADDILAEADFNFMYKYFSSEHSLNKAEVKEVSAILNELERSVVALQATLRPENCGGAVASAIDVDSLRSIHTRCVEIQQRIDSLITAAKQLQSRSEQCANLQDKLRQVTQEHERELASVRQQHEQKLGTLQRKIDEQQQRIQAIDTERAELLEKLNNERNLLKQKEKELHDLSVRLTRVEAASNEKDKEIEDLFDSYDQEQRKARSLKERCDELADSCRKTADEYAELEKERDYLFDQVRREQEHVKKLEKHLEMLETEHAQQVDNLHAAYREQQMANELDSQKDKDDEDSLRSRYQAEIEQLRALCEKGLAAMEASHKRIIHDLEEKHQQEIAKLILEKEQALAEETQATLAALDAMKKAHQNEVQREVTRFKQEFLKQFQKGGQPPQTYREKEQELEDVRLEILSLSEKYSMKCVETASLEEKLRIATQQLKCSQQHIQQLDVRNKQLRAHFISSPTEETASAPPTTSVVTPKDTNLGELLHSPTSMPPTAVGDSLLGAVSPTTTVAAENNTLEMLDLRDCQHLLLNNKKESHPRLKFTEGAKLGVAPIFSTSSSGSPASTATTVIDSVNLASSTNNNRAKVLSSKQLNMNLISGSGAGVGVGGGTSGSLAPPSPPTPHPVALTLPLITSATLKNSNLHRHNTTAPTRPEALAPSITTTTTTTFINSTIITTFTITTTISVVYITIIIIIMITITCTSLSHRLNFVRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAN0</accession>
    <name>A0A084WAN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative signal transduction protein GarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015302</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAN0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015302-RA">
        <property type="protein sequence ID" value="ASIC015302-PA"/>
        <property type="gene ID" value="ASIC015302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015302"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16327" checksum="4A38B651382911E8" modified="2014-10-29" version="1">MHHQHCLSETMRNPVEPRGRSVGAWKVARALAGGQRVRKNEECSVGRFHRTRHTAGFAESAWGACAVYVRGFIVSLFTSLSILRTILPPHEGAIKKALSFEDEATVKWRVRERDDRLADEMAVPSGLEGEKASAAKKCGNVASSLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD45</accession>
    <name>A0A084WD45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010205-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016202</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022933">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD45"/>
    <dbReference type="STRING" id="74873.A0A084WD45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016202-RA">
        <property type="protein sequence ID" value="ASIC016202-PA"/>
        <property type="gene ID" value="ASIC016202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016202"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005652"/>
    <dbReference type="OMA" id="FRMDIVI"/>
    <dbReference type="OrthoDB" id="7737165at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784699" evidence="3">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="77"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="426" mass="48519" checksum="85C4DAAFE6631B99" modified="2014-10-29" version="1">MGQNSLLLLPLLAIFCASVATEHPQPFQCVSQMEINSTEAALKSALFCGTSYNPRYRPVKYQQDRLAMYIGAEVINVERQWYDAFLHWNKRTSNNIETINVSEHDLWAPTFGAKSFHKSPRVQSTKQCSRVKCHLSYDGEVIYTVLCSFTVDCYSEARYWAFETKICTLRIFSVEYDTNQLSLFHFQRRLSYPSYPLLPYKITSFQMATVNSTMSPEFRMDIVIERLIGSHLIVFLGLIVIFSLLNLICLWLRMDSNARSVTIAVGTVMESLYLIILYWYGAVKMKPVLTLAHLLLGTSLLGAVAFGWTYYARGQLRKRIAASCPSTLTHFVVLLRKSRPLGSFLSIDYLNQSAKQDKLTKDWEDAPVDTVETQQHDGDVRTDDLHSSSDGEGGALEWQEVVQPLDRVLFCAMLTAYLLMFGVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDK6</accession>
    <name>A0A084WDK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008193-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00016279</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023042">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDK6"/>
    <dbReference type="STRING" id="74873.A0A084WDK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016279-RA">
        <property type="protein sequence ID" value="ASIC016279-PA"/>
        <property type="gene ID" value="ASIC016279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016279"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002858"/>
    <dbReference type="OrthoDB" id="7958563at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="324"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB48300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016279-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="530" mass="60106" checksum="E8D92CD89B44B966" modified="2014-10-29" version="1">MKIVGAAHCLYTFNRLMHKDQITVHVGRERLNGTTYDVQKLNVYKLIVHPEFQIGKMSNDIAIIKLDRDITMTAYVQPVCIWSFDDGHREIVDKNGTLVGFGLNEHDQQSGMLQEATMTVVDVYTCLESDRRAYGPVLARNMYCAGGTPGVSACNGDSGGGMFFAVNNTWYLRGIVSFIPMRLVRMCDSSKYTVFTDVSKYRHWIASLTIMPWGLSDLEPCRSELIDEDTICNAENGFDHGFLVLGDLNGVMRVPLNGGRYIKDFHNSTPLVGIDRDCVGGRIYWTDYKTKQILSAKYDGTDQKPFISKDFRHPWSIAVDWISRRIYWADSYNIEVASLDNPDVRTVLINNAYYSYGLAVDVNRGKLYWMTNLEISMIEWSNLDGTERQVLIGRPQIERPYYIRVSIVTGELCCQNGESIVCIDPYTKQIRTIVSNITDVDAFTLTEELFYWTNGKTDQLESIDPYGVRQKPIKFTPMETYVFEMVAVTDKCPVFHSPCATNNGGCPMDTICLVNQHIPSGKNCTKIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDP4</accession>
    <name>A0A084WDP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016322</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Ye Y."/>
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        </source>
    </evidence>
    <sequence length="2287" mass="251161" checksum="39014F4EEBC92928" modified="2014-10-29" version="1">MGLNKRDKQAKLNSQSLIDAERSHLTTSSTTTVTSVDHGSIALPLESLAVSSSTTTGGTKQDSNSKQLSSETVRKSSTASRASASEERSSSSTSTVQEQKFSTVSSVRSAASKSKQIDNIIEEIRHIASDTIDATEMIGTTVGGSGKVSQRTVLVSSGGSGTKDTAATSDQTSQQQEVITAIGPSKIEISKMALDANVQNSSNVISSSSKVLQSSAITKMEQSQSSHSSATSSEKVVSESSAISSSQMHDRSLQSSSNVVQSLSKSEQSSSKSSKATKMSSSSTSSSSTAMKNAHSKLQSSSSEAFHSTGGDTQFTQIASGFDRQDGSLAATSVLPDHSTFDQKTFQLVGDGGKTRQHVDSQRYSMAQSQAPTTKVMYDAAGNQITSTSSSYQAAQGYSTTSSSFQSSGDGADKLDKSSEVLKVNNSQTGATTTSSSSTRRADQHTSSSSSTNVSSSTSATKGTVIIDSTTLENYNRALEAASSATGQHSNHMLAKTESAHTVASLSSVHDSLAGTIQSTQLVTESAQSQADSSHHAESSRTYETASHYAQMDEESRSRRKTSEYREQRESNSAIVKRKTYDEHGRRLNLIDEKIVPKDVVTGDLQDDVRNVTKTSFEAKLFNPKLKRWELVDQKTILEQDVTTDIPAEIVKELEVERPELANITTTIQLTKVYDAKTKQWKTIDQKKHIDVLEKITFLEESSGRSELDESERIKNLKSMDMVDRVTIKEVNDRSASTKRKDERTVQEQCICEICTCGRHNCYNCGGGTAMSQTKSSKYTTMSNSENFYQQENFTSELNEQSSTVRRGTWTKEDAEQHQIRRESYTIEHSSTDQEATARRLTWTKEDFEKADITKLKTDYERPKPIRHEDNLKPEGDFHVPDRAGYTPAERPKPIRPDDNLRPQGAFTTPEKSEYRPAERPKQIRPQDNLKPEGDFERPEKPTVGKAERSKPVRHDDNLRPEGDFDRPEKSPFRPAERPKQIKPEDNLRPEGDFQSPDRPQYQPGERPKPIRHDDNLRPEGDFDRPEKTPFRPAERPKQVRPEDNLRPEGEFSTPEKPQYRSAERPKQVRPEDNLRPEGDFERPEKSPFRPAERPKQVRPEDNLRPEGDFQSPDRPKYQPGERPKPVRHDDNLRPEGEFDRPEKTPFRPAERPKQVRPEDNLRSEGDFERPEKSPFRPAERPKQVKPEDNLRPEGDFQSPDRPKYQPGERPKPVRHDDNLRPEGNFERPEKSPFRPAERPKQVRPEDNLRPEGDFEKQDKPQYRPAERPKQVRPQDNLKPEGDFDRPKPTTVGKAERAQIVKHEDNLRVEGTFERVEKTVFVSGERPKPIKPDDNLRPEGDFTTPEKQQYRPADRPKQIKPQDNLRPEGDFERPQKSTVGPGERPKPIKHDDNLRPEGAFERPEKATFKPAERPKQIRPEDNLRTEGDFEKPEKPQFRPAERPKQVKPQDNLHIEGTYNSFKEYNELKQQKEAVLKEVHEPGIADGAVLVTTQTVTTILKGDKKTPTGKQMTTTEVHDHHTARSESESVKHTSHSESHQQSHRSSEQVASSSTAVNRAHRTEASTNDTSDRRTTQQRSTTSHSQLIQDVSDRNINESSINDSHQRTMVNGKTVVNGGLSSQQVTSHSIKSSSSSSKIHQSSSSSIQQQQQSSMSSISSQSASHQLHHGEDHHIRTTNGTNILQPHHGGPGSDSIQQHSREQVTGSHVSSSSARVVVDGKVVTDKSASSKHATEKLAVDGVVVTDKSFTEKQQAGFDGLESIQSSQTTRGHSVQGTNNIIHGTTNASSTSASQSTKKSQSQSRSTNNITHTESVNGHSVQRNGTGGTSAAHMTSSSGQQVTETQVKKLIGGKWVTKTIKTEGKSSASQQHGLEQGGVAQNRSLVGETGGALVTNQQQHHSTVSASEMHATSSSSSSVSKSQSSSTIVSEKMVRERGVRTTEATPSAGSPSGRPGARGSSSIVLGESSVVDSASSKRQQQSSTTTRLIGGKIVHIANDGNNNMSTAAGKSSLNSIHGTASSTNAHSTVDRSSSKMSTATSNVVQSSRAESSSHLASTASSIGQQQSSSQQQHHRKNTFASSENVNNSILCRPAQTSTTSSSTVHGANGAIGGAMSVSATAQRKSISNLNDNAIYSTTNRTSYSSLHRREKESAEARMQNYVKTLETGTITNRTVRGQPCPPPSLAGTGLASGGGVGGGRVSSMNTSTLSSSTANQKQIRDYHSAMNVTRSSTKANASSISFGDDKFHGSSSYKVQYIQQHDGRCPAAAHDNLKLSKVTKQHTYYVRDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGG1</accession>
    <name>A0A084WGG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017421</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGG1"/>
    <dbReference type="STRING" id="74873.A0A084WGG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017421-RA">
        <property type="protein sequence ID" value="ASIC017421-PA"/>
        <property type="gene ID" value="ASIC017421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017421"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019037"/>
    <dbReference type="OMA" id="DETRHSK"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017421-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="251" mass="27931" checksum="F5FBEB920A0CED88" modified="2014-10-29" version="1">MAANHRQLLGPAWMTSASTIRVKTQDALDNRPLLPKATPTEQRKERSAKGAGNGGGGEAAGGEDSPKVKIVMDKEFIFECLCWHNEYRMRHGAPALSVSSELCEYAKQWANHLASTNELYYQIGTNYGQNIFCCPANSLLTDLSGQEVATYWYSTSRRYDYFKESHLLHTNVNTGHFSQMVWRGSRYFGVSKSISKTGKLFVVAYYYPAGNVMGEFRQNVLPPIVANEEAAPSHLSRPPSAKDLENLSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH09</accession>
    <name>A0A084WH09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017706</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023778">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017706-RA">
        <property type="protein sequence ID" value="ASIC017706-PA"/>
        <property type="gene ID" value="ASIC017706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017706"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="19277" checksum="F394E1E50D4AE971" modified="2014-10-29" version="1">MGRTFEYWTGCGTKTVLSPDLNASENDVISLDDSESVDESSLGENPVSVERNNSTHEEDKESNIGQTITDDETDAEALDGNESDASMPALHGEVVEKASNDKLIAETEDEKGSNCSTKNSGKSEQITERDSSQSYKDTSTNWWKKNRLLSDGSDSDDSVTSLYGATIVEKYTQLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH95</accession>
    <name>A0A084WH95_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017602</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017602-RA">
        <property type="protein sequence ID" value="ASIC017602-PA"/>
        <property type="gene ID" value="ASIC017602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017602"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11841" checksum="E9C7E1584566D420" modified="2014-10-29" version="1">MLLPPPTSLLTLTLVWPPDRGWVVRTLGEKCTLGRLDERAHEPHEDEMKVCAWGEFLGAVFCVVRIACCQEWKKCKEKKAKENSSPSEGTPYQRRAWTTGIGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHV0</accession>
    <name>A0A084WHV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012299-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHV0"/>
    <dbReference type="STRING" id="74873.A0A084WHV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017811-RA">
        <property type="protein sequence ID" value="ASIC017811-PA"/>
        <property type="gene ID" value="ASIC017811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017811"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011827"/>
    <dbReference type="OMA" id="CRVTMHD"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13442" checksum="C5F0D23718DCC87C" modified="2014-10-29" version="1">MQVEPSLLAVSCIASATRGLNVSTKLAVGYDLCRVTMHDLEKIDFIVKIIEEIVAREIADKQCQQQQQQAAQQQAQLAAAGSSCKEQYQQAPQKLSASTANSSSGPPQQQQPETPTDVQFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI94</accession>
    <name>A0A084WI94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP012082-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017972</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI94"/>
    <dbReference type="STRING" id="74873.A0A084WI94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017972-RA">
        <property type="protein sequence ID" value="ASIC017972-PA"/>
        <property type="gene ID" value="ASIC017972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017972"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="37030" checksum="1136F78B24E582E9" modified="2014-10-29" version="1">MLLLSNVVEMFEQRKIIVDNLTSLKELKEDKDDDMQQLLKEERDAYGSILVRLDNEIMEGILSMDDEEDYGSLIMEVTAGVGGQEAMLFARELFDMYCGYVNYKGWDVEMLDCEDTDIGGTRHATTIISSPEAYRYLKYEGGVHRVQRIPATEKSGRIHTSTVTVSVIPRPDDFEVDLKEKDLKIETKRASGAGGQHVNTTDSAVRIVHLPTGIAVECQTERSQVKNREIAKQKLVAKLTQIELEARFSNTQALKKSQVGQSLRNEKIRTYNFNQDRITDHRIEGGTVHNLKGFLEGGEELDSMIEKLRRAQRRKQLMDIIQRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIF1</accession>
    <name>A0A084WIF1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">PilT protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018035</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018035-RA">
        <property type="protein sequence ID" value="ASIC018035-PA"/>
        <property type="gene ID" value="ASIC018035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018035"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7610" checksum="E908C6AAA8966768" modified="2014-10-29" version="1">MADIGPEMVRAPKCGLLRRAHFLSEQPNPALSEQQNQQPLEQAVFRSLSLSKSGYYIPAPNRRDSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJF8</accession>
    <name>A0A084WJF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005075-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018623</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJF8"/>
    <dbReference type="STRING" id="74873.A0A084WJF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018623-RA">
        <property type="protein sequence ID" value="ASIC018623-PA"/>
        <property type="gene ID" value="ASIC018623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018623"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003843"/>
    <dbReference type="OMA" id="ITGCGLK"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000131">
        <property type="entry name" value="acidic leucine-rich nuclear phosphoprotein 32-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="35008" checksum="67CFADFB25E53AF6" modified="2014-10-29" version="1">MEKRILLEKRGRSDDQITELILDNCRSTYIEGLTDSLTALETLSLINVGLVSLKNFPKLSNLRKLELSDNRISNGLSNLTGSPKLTHLNLSGNRIKDFEELQPLKHLQNLEVLDLFNNQVTLIENYRDKIFQLIPSLAYLDGFDKDFAEAPSDDDECVATEEEEDSCEESDDVSLAYLYNENLEEDQEDWKSVESDYNNDVDDEFDTEDEEEDGEEDGGGGDGAANDGEDGPDSDGSGGLEEEDEDEDGEDAEDGDEAAEAADAPAEAEAGSTAATAAAAAATTETEAAASAAAGDEEDSEAKATESETRGKKRKFEGTDSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJJ1</accession>
    <name>A0A084WJJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005736-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024036">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018409-RA">
        <property type="protein sequence ID" value="ASIC018409-PA"/>
        <property type="gene ID" value="ASIC018409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018409"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008640"/>
    <dbReference type="OMA" id="EGGVHNM"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF13">
        <property type="entry name" value="LETM1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="199"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="380" mass="44427" checksum="FE3088D8D8B7C360" modified="2014-10-29" version="1">MSLTLLRTLCRHQPLLQQRQPVSFVSSCAGFAIRFQSTGPTGGGNSKDGSNDKQSTKERLAVKYSRENVKRNVQGYVFSRFFDYVKNYDKVLEKKFPSAMHVYRVFLVGVRDFFNDMKKLVKITKIVYSHDNDLRCLTRKEIELYYQMPRDMKKVAPVLLISALPFANYVIFPLAYMYPRILLTSHFWSIQQKVEFAQIDLRNRLVYNRRVFRCMQSKLDVLKKNDDPSYKKFRYILGLLGSGLHPTSEEILDVKEVFQRPPFHLNSLASSHLKYLCRLHDVRAGILRRFRLSERAYIVHHMDMAIKREGGVHNMPIESLKHACFLRGLNATNLSAESMIEWLQEWVKVSLVVNEDSISLLLHLPILLTYNHPNNWILIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJP8</accession>
    <name>A0A084WJP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Iduronate 2-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018472</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024046">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJP8"/>
    <dbReference type="STRING" id="74873.A0A084WJP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018472-RA">
        <property type="protein sequence ID" value="ASIC018472-PA"/>
        <property type="gene ID" value="ASIC018472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022440"/>
    <dbReference type="OMA" id="HVFTRAY"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760014" evidence="7">
        <location>
            <begin position="23"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="524" mass="60390" checksum="A3F260060E911944" modified="2014-10-29" version="1">MKIVKVPLLFLCTTILVGVIESQIIERPNVLLIILDDFRPAIKNGYGDENAITPNIDRLVQDGYYFTNVFAQQALCAPSRNSMLTGRRPDTVRLYDFYSYWRQTAGNFTTLPQYFKQNGYHTHSVGKVFHPGTSSNFTDDYPLSWSEPTYHPSTDEFSNAPVCIDPEDGGRLKRNLLCPVSPEMQPLHSLPDIQSTEEAKRFLQAHRDGDPYFLAVGYRKPHIPFRIPFQYLDLHLKSKFTTLDLDYPPYGLPNVAWSSFLDVRDRDDFKRLNVSFPFGSVPEDFKLRIRQHYYAAVTYVDDLIGQLLKDVDRSKTIVALTGDHGWALGEHGQWAKYSNYDVAVRVPLIINLPDALSSSIDERRIDKVVELLDLFPTLVDLAGLPAVQRCNEQRPHKPQTCVEGKSLYSLLQRNLSTSNAESDEWIAYSQYPRPGPYPTLVPNSDEPKLKYIKIMGYSMRTERFRYTAWIKFDPLTFKRDWTTLYGEELYDHAIDPKENMNLIDREPLSSIRHVLQAKLKEKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKP4</accession>
    <name>A0A084WKP4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024131">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKP4"/>
    <dbReference type="STRING" id="74873.A0A084WKP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018839-RA">
        <property type="protein sequence ID" value="ASIC018839-PA"/>
        <property type="gene ID" value="ASIC018839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018839"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009290"/>
    <dbReference type="OMA" id="DIICERG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018839-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="770" mass="86567" checksum="5CE77AD985C0A649" modified="2014-10-29" version="1">MGEKSGNPYDMDGPSFDADRYLQKLLKECSLKQIMDTEAAIVRQTQTLHSDMQTLVYENYNKFISATDTIRKMKTDFKSMETEMNLLMTNMQSITDFSERITDTLQETRSQLTRLSGKHQLLKKLQFLSSLPAKLKTLIEEENYQQAVQEYSHAQKVLQQYGQQPSFQGIQEDCIKILDELKDRLRGEFRQTGKSAQSLTEIGELLLQLGERPSTLAKEMLECASKRLHEQIVVLQDQTDRDMIEFIDLGIEGFLKDLTLVISSYNDMFLARHLDQEADNFEQVARLDLNEFVNRNVDEYLALVQDRAELEIGHGDSQIILRGLDRLHRRMTAMRTLCKAVDMSKSGLDIIVGAAQQLCQAHMKSLKDHFADSLSSIRLALVSSNTASASNSGSGSSSQSTSGAAAGGQVNPPSTGTGTGGLRELISNLYVSTIEKVKGLMQDLLIFLQPEWSFNLKSDPKGIQCIEGIRENLLVAFLRHFCCTVNGYGSISSTAPPTLLLVLSKVCLEMERAGVHTLTALVDELYSIDSERSVTLVHESELCAEMRDSAQLLLDSYVRLQALNLSQMLRKSVETRDWLNCLEPRSVRAVMKRVVEEISAIDLVLGELYDGSSHAHGTGSRTTASSDSSRKTHFSSIGTSKQSQFRSTWSTYTPQSQMDSSFVSNMQRLFSEKIEIFAPVEFSKVSIITGIIKICLKTLLECVRLRTFSRYGLQQIQVDAHYLQMNLWRFVSDENLIHVLLDEILGSAVLRCLEPILMEPNAVEIICERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKQ8</accession>
    <name>A0A084WKQ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018854</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKQ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018854-RA">
        <property type="protein sequence ID" value="ASIC018854-PA"/>
        <property type="gene ID" value="ASIC018854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018854"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="5844" checksum="4C2839070F03A442" modified="2014-10-29" version="1">MRAFSSEKAVSERCSSSSSFFTPPLYTGGDSTGLPFPVEADALVNNFIVTSTCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKZ8</accession>
    <name>A0A084WKZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007156-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019239-RA">
        <property type="protein sequence ID" value="ASIC019239-PA"/>
        <property type="gene ID" value="ASIC019239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019239"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012312"/>
    <dbReference type="OMA" id="VYERTFH"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784870" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9301" checksum="A50AF7B93FC0DC31" modified="2014-10-29" version="1">MFKIVCLFAILAVASVSAKADPKPGVFAYAAPAAYVAAPAAYVAEGAAVYERTFHGNTAPLAYTYAAPYVAAAPVAYSSPYVAAPAQVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL90</accession>
    <name>A0A084WL90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019028</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024203">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019028-RA">
        <property type="protein sequence ID" value="ASIC019028-PA"/>
        <property type="gene ID" value="ASIC019028"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019028"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019028-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="15025" checksum="4067ADFA3BABAFC7" modified="2014-10-29" version="1">MAFYSRTNHHATATLITENKKGKIKQRRAAEKGKHAYYGILSTAKIPSPAPPPPPPPAKAIDGNRCSIKYNQAKRAPCERTVVQCFDRYQFVYFDMLSSGGVWCLEAFGTEVREGELLVVYQPRISRRNISQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLJ3</accession>
    <name>A0A084WLJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP006729-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLJ3"/>
    <dbReference type="STRING" id="74873.A0A084WLJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019143-RA">
        <property type="protein sequence ID" value="ASIC019143-PA"/>
        <property type="gene ID" value="ASIC019143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019143"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005558"/>
    <dbReference type="OMA" id="YHIMPDF"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="322" mass="35285" checksum="161CE73F165A8233" modified="2014-10-29" version="1">MASLDTQSLLFEEKALHTPSLGEIRDVLATGLKSSFATVNVEVVECPDLTKAPFHLAGRGLNGSPTLVEIGGPPYLLPNVDRSKLYDLVSVSQRALHDTKKEFIAIGAGAGPFPLVNSNCEGMFNLRYTPPGTVVSESHLAVISPTDRTVTVHKIPNTETRCALLGNILVAEGKPGQVLKVSCKRRTGKKDFIASIRTCLEGHYGERTVGLGGVFLLQTGKAKQHVMSPFSETPINTEEELNEWLNFYDMPAPLINVGTLVTTECDLDLRLQHFHSFSTHGHGGHYHIDTTPDIVEYEGYFIVGERIVRVDKPVNTHKFGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLW9</accession>
    <name>A0A084WLW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019478</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019478-RA">
        <property type="protein sequence ID" value="ASIC019478-PA"/>
        <property type="gene ID" value="ASIC019478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019478"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="12358" checksum="D5EABE25ACCFB981" modified="2014-10-29" version="1">MAGAGYNDVEFDTGSMTSVRTRAYNRKCTPKCTGNVRQYGKCGVEKRFIDRFIDRNFAETERPELGMPFRCSGMHSTVQRELMHRPRSKTRRRPPTTFAIAYLSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM48</accession>
    <name>A0A084WM48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019343</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019343-RA">
        <property type="protein sequence ID" value="ASIC019343-PA"/>
        <property type="gene ID" value="ASIC019343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019343"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="24516" checksum="32F738B3D8F2427C" modified="2014-10-29" version="1">MREQIKTIHFASLGLPKGLTGERGISCVRERYLIVALGRLRLVEGPESKWGETGRRKATPPQPNDSLSLHRIKTKQTDRNNEPPSTGWGCSTMSRKNSPPRTPVFSVHILSQTAWNRTKNWPVLSAGSAERIDKTVSRSTQKGRVFPMFVGKGEREREGKAPLPLKFGRKNDVTSASDTAMANIFRCEWKEEKCDQKTGRGLFAKALCLLRCLGRKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMK6</accession>
    <name>A0A084WMK6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019501</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01024481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMK6"/>
    <dbReference type="STRING" id="74873.A0A084WMK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019501-RA">
        <property type="protein sequence ID" value="ASIC019501-PA"/>
        <property type="gene ID" value="ASIC019501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019501"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000778"/>
    <dbReference type="OMA" id="MQANWSK"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="311" mass="36176" checksum="CD7BE039AFE5D9E3" modified="2014-10-29" version="1">MNVEITPNYSYIFDFENEFIHQDTRVWMVKNWTYVFYYCGIYMAVIFGGQYYMQNRPRFELRGLLAIWNTLLAMFSIMGACRTAPELVHVLRHYGLFHSVCIPSFIEHDRVSGFWTWLFVLSKLPELGDTVFIVLRKQPLIFLHWYHHITVLMYSWFSYTEYTASARWFIVMNYCVHSVMYSYYALRALNFKPPRSIAMLITTLQLTQMVVGCAINIWAHGFLQTAGKNSCNISEMNIKLSIAMYFSYFVLFARFFYKTYLSTNARKGKRPIQVTASSTATSGQYISSSINGKSDVQSLLAGQATSKIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNA1</accession>
    <name>A0A084WNA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019781</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019781-RA">
        <property type="protein sequence ID" value="ASIC019781-PA"/>
        <property type="gene ID" value="ASIC019781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019781"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="14901" checksum="AE523DD66BF4A334" modified="2014-10-29" version="1">MNDNKKHMDEIGGALPEEMELDDIEERILAVTQLNNNATSEPECIYIKAEPTAVELQEETGSSDTDSCDQEEGGPSNTQGSNDEEEGGPSNTEAKIDQDIKQVSQTASARQPHDDDKIEILIRQNDAIIKFLSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP04</accession>
    <name>A0A084WP04_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00020115</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024805">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525361">
        <property type="protein sequence ID" value="KFB51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP04"/>
    <dbReference type="STRING" id="74873.A0A084WP04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020115-RA">
        <property type="protein sequence ID" value="ASIC020115-PA"/>
        <property type="gene ID" value="ASIC020115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020115"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011622"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="17">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="223"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="424" mass="48355" checksum="3F4426549B88B6EB" modified="2014-10-29" version="1">MTITEYIGALAENPYFGAGFGLFGVGAGAAILRKGMQGAMILFRRHYMITLEVPCRDKSYQWLLQWITQKGARQTQHLSVETSFEQRDTGHVKTRYDFIPSVGTHIMWYSGTWIKVDRAREQHTLDLHMGVPWETVQLTAFGRNKNLYFKILEEARQLALKNTEGKTIMYTAMGSEWRPFGHPRKRRPIGSVVLDQGVSERILLDCREFIKNPQWYSDRGIPYRRGYLLHGPPGCGKSSFITALAGEIEFGICLLNLSERGLTDDRLNHLMNVAPQQSIILLEDIDAAFVSRQDTLQQKAAFEGLNRVTFSGLLNCLDGVASTEARIVFMTTNYLDRLDPALIRPGRVDVKEYVGHCSRHQLEQMFRRFYTGTDAEENARLFAERVSADGRNVSPAQIQGYFMVHKMSDQQTVLDNVQDIWENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPC0</accession>
    <name>A0A084WPC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020269</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025021">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525368">
        <property type="protein sequence ID" value="KFB52064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020269-RA">
        <property type="protein sequence ID" value="ASIC020269-PA"/>
        <property type="gene ID" value="ASIC020269"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020269"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020269-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8333" checksum="5D532FFF10D4777D" modified="2014-10-29" version="1">MSSPVFQPAQKTTCQRKSAGGESDDSVTDSKWNGLSDDDVDGDEHKNAEGSDYRALHQGPGQKFRPNEDPALRMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPQ7</accession>
    <name>A0A084WPQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000929-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00020308</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPQ7"/>
    <dbReference type="STRING" id="74873.A0A084WPQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020308-RA">
        <property type="protein sequence ID" value="ASIC020308-PA"/>
        <property type="gene ID" value="ASIC020308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020308"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004514"/>
    <dbReference type="OMA" id="DWCPEPP"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000076">
        <property type="entry name" value="Furrowed, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000105">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 8" id="KW-0768">Sushi</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="227"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="414"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="473"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="531"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="649"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="709"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="789"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="849"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="908"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124965" checksum="5C21F2679E39BFE2" modified="2014-10-29" version="1">MHSVCGPPAIPANAKVHTEKAEGASGGLKSARYDCDSGYELFGPETIRCDPVKGWDRELPFCGTNVAYRKPVNQSSATRSGPAGFANDGKPGNQNPDGQECSETQKEVSPWWRVDLLTPEAVRVVRLTTRGCCGHQPLQDLEIRVGNSSTDLQRNPLCAWYPGTVDEGTTKSFTCARPLIGQYVTVQLVGVESSLSLCEVEVFSNDEFSSDRCASPNLSVDTVLTTFAKTCYEFHITRGESFEKARAVCQSHGGDLIHDFRGITTDYIISELERRKSDLRTQLVWIGAQKEPGITSRTWKWVNGDTVIKPTWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNLDYLNYICQHSPLACGSPDALVNTTVVGRNYSVGASITYRCPVGHSLIGTEVRTCQQNGVWSGGPPTCKYVDCGALPDIEHGGIILSEQRTSFGVQASYTCHENYTLIGNENRTCEATGWSGTQPKCMVDWCPEPPPIQGGAIKVSGRRAGSTALYTCDYGFVLIGEPVLSCGLGGNWTGKIPVCRYVDCGMPARPDRGNILLLNDSTTVGSVVRYFCDDDYWLVGPQELFCTKDGKWSGNAPACELITCETPHVPPGSYVIGYDYNIHSSIQYHCDPGHILRGEDTLTCLESGQWSGDAPDCVYVDCGPLTPIPFGSHRYLQNTTYLDSEVVYSCANSHRLSGVSRRICLDTGLWSETAPRCEEIRCTEPTLTPHSFVSVTGNDRMYGRTLIRTSDATASGAQTFKVGALAKYRCERGYKIVGEALITCEENGQWSGEIPECVYVNCETPAGIANGKVTLATNATYYGAAAMYECDGNYKLDGVSRRICLEDGTWGHEQPQCVEITCDELSFADAALLVNVGTRKVGVLAEFSCSKGRYMVGNGTRTCLPNGQWSGRNPVCKLIDCGRPADIENGRVIVVNESTVYGGSAEYHCVPHYNRIGPYLRKCMDDGKWSGEEPRCELIVNDAQETNSLGTGIAIGAAIIVILLILIGVLFLHRNKARPVKNTENVQAAEHKEDQNAAVMSYSSLENGRHNFDLTNRGGLVTFNTFHQSAGPHPPPPSQLTHGSSNNNNHLSSSINNNNVNSNNGSLRGGENIYDQIPSEQFYDAPYEMRTNEEVYEPEPTSRGNIITINGVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQD6</accession>
    <name>A0A084WQD6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00020663</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025535">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525392">
        <property type="protein sequence ID" value="KFB52430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQD6"/>
    <dbReference type="STRING" id="74873.A0A084WQD6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020663-RA">
        <property type="protein sequence ID" value="ASIC020663-PA"/>
        <property type="gene ID" value="ASIC020663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020663"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002673"/>
    <dbReference type="OMA" id="KREVCKT"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB52430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="512" mass="58918" checksum="94DE76CFB06700B9" modified="2014-10-29" version="1">MIKFCAGVQITEEDDLPRYVCTKCSEETTFAYMFVNKCRKSDAELRTQQILGPREEDISGEQIECLKSVVQSEVQSDGVGETGQLGVECYDFELLDDTVDGASLHSWHDHSRDDEATETNNEVEPEEWVILEEEVLCESEGEETKLPSNGLDEGGTKQHDKCTDRIDYLDQSDDSIYFCCNTDCTATFTSKPKLIEHFQSLHAAENDSESEYAIEPSCYRCANCGQSFRSVDELKRHENRLHLKRAALCRRQFGRPKLYPSIFDASEKICCGCFERFATTEELLAHSETTHAIRKTAIDPDRPAQCQICYKLFRSESHVRTHLISVYKSRKFRCTDCDARYTTASKLAHHRLVQHAGPGKYVCGECGASLKSEHNLKMHSLLHREKREVCKTCGLRFHRKSNLKVHQRIHADTFYYACTHCPKQMKTMSQLKEHVKVHTKEKPYPCRFCDKRFRYCTDRTRHEMVHTGNYPFECSGCSKKFARSFSYYRHRNKCGASNEAPFSRTAALDDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQZ3</accession>
    <name>A0A084WQZ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020889</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525401">
        <property type="protein sequence ID" value="KFB52637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQZ3"/>
    <dbReference type="STRING" id="74873.A0A084WQZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020889-RA">
        <property type="protein sequence ID" value="ASIC020889-PA"/>
        <property type="gene ID" value="ASIC020889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020889"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011439"/>
    <dbReference type="OMA" id="YQLGYAQ"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17137" checksum="02B1D296E11DA8FE" modified="2014-10-29" version="1">MSTFQIDARVDAEEIVADDINDVFEDIFLAEERIIEESFHLGLEDGRQEESVKEAHDYGFKKGSEIGRELGFYYAIVTEVASQEDNATNEKARTILAELIDAIEKYPRENEPTVDLLHCLQQIRNKYRRLCALLKLPYRFTETNVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR36</accession>
    <name>A0A084WR36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013281-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020936</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025915">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC020936-RA">
        <property type="protein sequence ID" value="ASIC020936-PA"/>
        <property type="gene ID" value="ASIC020936"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020936"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016094"/>
    <dbReference type="OrthoDB" id="8023715at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785081" evidence="1">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020936-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="28607" checksum="3074EDF9A6B25827" modified="2014-10-29" version="1">MAIQMEQVLFLLVSLCAVLSAGDHTPPFKPLLPSGYGKSAPLMGFPSFVPKHGGGLKPYMTQFRAGTRLAPVAIRPAPSMIMSLKRPIKSILSHPSLMKQPLLKRHPPLSSFAAASIKHHKFHSSPAGPSTGDIVFEKLKPITTKLTSHKDGAIHTIPAPNLGLTKPPAGPNQIRVSSYEDSNKLEIEVKTTKPTLTPKPAFLYSPTVTSDHRQPLYGDLASLISSLQPAPAVVPYNHQHHHHIIANPHXXXXXXXETNTCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRV4</accession>
    <name>A0A084WRV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021227</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026222">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525408">
        <property type="protein sequence ID" value="KFB52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021227-RA">
        <property type="protein sequence ID" value="ASIC021227-PA"/>
        <property type="gene ID" value="ASIC021227"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021227"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021227-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13271" checksum="45412B3760F20CD7" modified="2014-10-29" version="1">MYSFISKQTPFKASPLSPFENAAAVIITHRSSLPIPLPPPFCPASTTTIGRRAQVEVASRRVRDHHPPLLQWPLVVCAGHMSDLAQTLVPYGSSAPGANFPDPTVGVTVLARSDRKYYSSSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSR2</accession>
    <name>A0A084WSR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001585-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00021594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026696">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525417">
        <property type="protein sequence ID" value="KFB53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSR2"/>
    <dbReference type="STRING" id="74873.A0A084WSR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021594-RA">
        <property type="protein sequence ID" value="ASIC021594-PA"/>
        <property type="gene ID" value="ASIC021594"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021594"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022794"/>
    <dbReference type="OMA" id="MLDMHRR"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001571">
        <property type="entry name" value="Deoxynucleoside kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021594-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="28356" checksum="BECBECA306A06D9E" modified="2014-10-29" version="1">MPPIANEKLGSSGKKPFTVFVEGNIGSGKTTFLDHFQKFDDVCLLTEPVEKWRNCGGVNLLDLMYKEAHRWAMPFQTYVTLTMLDMHTYKTDKSVKLMERSLFSARNCFVESMLASGSLHRGMYNVLQEWYEFITCNIHIQADLIVYLQTSPEVVYERMKQRARSEESCVPLEYLKELHELHENWLIHGTSHRPAPVLVLNADLDLNTIGTEYKRSETSILKPILIENTNHHAILTSPSKRAKTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT71</accession>
    <name>A0A084WT71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021816</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB53415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021816-RA">
        <property type="protein sequence ID" value="ASIC021816-PA"/>
        <property type="gene ID" value="ASIC021816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021816"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021816-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9853" checksum="7023143E88BA4557" modified="2014-10-29" version="1">MVTTHTFATPGVDGVDEDGMVVKKKEASTKRRRKPTRCVRSLPKKHGPKTKARSVQSLTASETDVSSEGSAQFREDLVEAAVPGARWSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU62</accession>
    <name>A0A084WU62_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022137</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022137-RA">
        <property type="protein sequence ID" value="ASIC022137-PA"/>
        <property type="gene ID" value="ASIC022137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022137"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022137-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19028" checksum="6274495FC92354DA" modified="2014-10-29" version="1">MGQQRRFVHHTDIFKVTAASFRLSGGKLAFPFASGVRLRNRPIFRDAPVSFSQQHTHDAVPGLGKGGRPGFKVPIRSVPVLCAVLPTEEPDFSPPNPEGVRAGTDLARDFGNDWGTARTGWKFRQNGRKASATSGGRATKQLFGQSTKPEFRTVLLETDRLVWPGPEMRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WV27</accession>
    <name>A0A084WV27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005461</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013752">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL646758">
        <property type="protein sequence ID" value="KFB54071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WV27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005461-RA">
        <property type="protein sequence ID" value="ASIC005461-PA"/>
        <property type="gene ID" value="ASIC005461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005461"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760068" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB54071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8215" checksum="4DB70E9EB210669A" modified="2014-10-29" version="1">MRAVRVMRCWRRWCGSGSALVVCCLEEEGRPGDAGGCGVFPNDARLQSHPHQRIGRWLTFGRFRIVARCVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB00</accession>
    <name>A0A084VB00_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP011982-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00001062</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004813">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524240">
        <property type="protein sequence ID" value="KFB35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB00"/>
    <dbReference type="STRING" id="74873.A0A084VB00"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001062-RA">
        <property type="protein sequence ID" value="ASIC001062-PA"/>
        <property type="gene ID" value="ASIC001062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001062"/>
    <dbReference type="OrthoDB" id="7553586at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="26"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20278" checksum="02AE2DDD53A02B95" modified="2014-10-29" version="1">MLAVIDRAIELKRGFKLRDTQKLAVLALLANDGSTLAQVSTGEGKSLIVVAASIMKALFGEKVDIVTSSSVLAKRDAENNSDIYSLFGITISHNCSEDIEKRRQAYSLNQVVYGDLGSFQRDYLLDRFYGKNILGDRDFANVIVDEVDSMLVDKGNNMLYLSHDIPWMDKLESRATMRSTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBP1</accession>
    <name>A0A084VBP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP002997-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524483">
        <property type="protein sequence ID" value="KFB35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001956-RA">
        <property type="protein sequence ID" value="ASIC001956-PA"/>
        <property type="gene ID" value="ASIC001956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001956"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011524"/>
    <dbReference type="OMA" id="RMCEGIN"/>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF1">
        <property type="entry name" value="PROTEIN SALIVARY GLANDS MARRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="24750" checksum="998823E57BA18C8D" modified="2014-10-29" version="1">MYNMSAASILELQSWIVYQHIAAECANCLFMTDNAFKAKDIGLRAQKKILSRMASKNVAKVFIDGTTASLLDNVYRLVKVHTGSKKDAERLVKNIIKIVIKIAVLHRNGQLNADELRQADRFRAKFQTLQMAILSFYEVDYSFDLGYLQKSLGDCRSLLRACVVRHLTDKSLGRIDEVFDTFADSALLETAFRQDSPYREIMDKIVVDLNKAMENGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCM7</accession>
    <name>A0A084VCM7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP012173-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002620</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCM7"/>
    <dbReference type="STRING" id="74873.A0A084VCM7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002620-RA">
        <property type="protein sequence ID" value="ASIC002620-PA"/>
        <property type="gene ID" value="ASIC002620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002620"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001519"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="23574" checksum="B3C8C158401D3432" modified="2014-10-29" version="1">MNKDDLKYIILCAARSYLVDHRRLVPIFRYLLEATEDLWTVDRKGRTLLHYFARVGYVYMVKYLIEQKGFSPQTVNDKNGWNAFHYCVSATNMPKGSEPNYCTIFRFMMEKERAVGIHAIGFDGNNVLQVAVENHHFSVGKLIVASVLENVTTSNAQQALKEYFEVSNLSIRRQFGDFLDFLIDDEQGDFKDVFRSVKEQLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDC8</accession>
    <name>A0A084VDC8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00002956</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524659">
        <property type="protein sequence ID" value="KFB35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDC8"/>
    <dbReference type="STRING" id="74873.A0A084VDC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002956-RA">
        <property type="protein sequence ID" value="ASIC002956-PA"/>
        <property type="gene ID" value="ASIC002956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002956"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012887"/>
    <dbReference type="OMA" id="AMETFTV"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19492">
        <property type="entry name" value="Rad51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002382">
        <property type="entry name" value="DNA repair protein RAD51C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="285" mass="31805" checksum="061C49420B3D8C80" modified="2014-10-29" version="1">MFEKSALDLWKEECDRVGIATFCKDLDYALGSGIPQGMITELCGPPGSGKTQLCLQLSVNVQIPRSLGGLEGRVAYLDTNYGFSPQRIKEISLGCYEHFSKLVRLRKQHEADRLDSFLPDSILGNILYTHVTSYTHVLEAIAVIQNKLHDGDKIRLVVIDSLSFLIRNTINRTLERVRCLHEILTQLHKLAHRFECVVVITNDVTTQLLSDTGSSDRTMESLIVPALGGSHSHKINQRIILGKDDSESGQQDTYVALIDKCHFSPKISIAFRIETGGIRSVKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDD5</accession>
    <name>A0A084VDD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004464-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002953</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
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                <person name="Chen C."/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="1715" mass="171813" checksum="68DDFACF3FA1BE7C" modified="2014-10-29" version="1">MIEQFGMPTLPSGISPTVGMCNGTLSPYQTHPEPAYNLNQDTVLSIPTATSFPDGFPVDFSLLVALRASPGLERAPLFAIYSSDSDEILMLMVGRDVALYYYDGNPEDDEQDQYQNMISFGVGIDDERWHRLGLSVKGNSVTLIVDCVTQITRPLNRRPGAQLVTDGLILTGLQLNEENGFFTGDLQLFLIANTPDEAYNICTKYAPDCPGGSTGSFRTVSVHTTRTTTNGTTGSVTRTQTSTRTTTGGGVGAQTAGANIRDQVLRESVSITSGGGSSGGARGGGRQTSASSTSSITTGGAERDITELYGDVEGLEDRSVGFPSQSTVMIVGGVKTVRGPRGPPGEPGPKGDPGRDGLGGQSGPPGPPGHVFMMPLTSAGNEKGPDSQAEALRQMLSQHMTAMRGADGPMGLTGVPGAVGPPGPEGAKGEPGEVGEPGPLGPRGAVGAKGNEGRRGRSGRDGERGATGLQGVKGEQGPIGLPGFPGEKGERGRQGVVGEKGSQGHDGAQGEDGPPGLPGLTGELGPRGFPGPRGFPGPSGNPGLPGSEGIPGSKGNPGPQGQPGAPGQTGSTGPVGPPGPQGNLGPPGIPGPHGKPGLPGLPGADGPPGRDGNQGIAGPKGDLGPQGVQGPIGFPGNRGPKGDDGERGATGDKGEKGEQGHDGDKGDMGPPGERGHQGATGVAGSEGPEGPKGFEGPRGETGMMGLTGDKGKQGVQGFPGYPGPPGDKGDKGSGGMAGRPGEKGERGNTGLQGERGEVGPKGFRGPRGRRGADGTTGPKGDTGQPGPPGAQGEIGMQGPEGPRGFIGMPGPPGNNGKDGPPGASGERGPPGENGNPGPIGAPGVVGPQGPTGEPGPVGEPGIPGLPGLPGEPGVPGDTGKEGQPGPPGPPGKNGPQGGQGLPGFPGERGMMGMPGLPGLKGELGLPGLAGPVGDKGQPGEPGKEGPPGPEGRPGPPGPPGPFGAKGERGEQGLIGPVGRDGLPGQRGLTGPAGPVGPPGEDGDKGDSGPPGEKGFKGAQGEAGPVGSPGSQGSRGEPGATGPAGEKGPPGEIGRTGPKGEDGPTGLPGSPGPAGPQGMPGPPGMKGGRGDDGPPGSVGPAGPPGEPGRRGPRGAEGGPGAPGSPGPQGIAGEPGMQGPPGPIGPEGKEGEKGAMGPKGEEGKSGPPGPPGKRGQPGLEGPKGVAGPPGFPGNPGEPGLVGPKGDIGKDGEDGKQGEAGQPGEQGPPGAPGEHGPPGKIGPEGPAGPQGTTGLPGEKGDRGLAGPPGNQGLTGPQGMPGSQGSPGLRGSPGPSGEIGPVGKPGESGQPGKAGEVGPKGPKGERGRRGLKGHRGELGLVGLKGDAGEKGDKGMRGITGPEGPKGETGPLGPVGPKGNDGPQGPPGNEGPLGPKGTEGIAGLRGEPGPPGPPGPPGPPADAPLIPPELLFRMNEFTLTKGEDRQKRDAGDAMPDDELVLEDDFDEEILRVEPRKKTKKKKPKSKPSDLGPKFLDMYSSIYSMRQELDRIRKPVGTRENPARTCRDLHHGHPQFKDGWYWIDPNLGMGDDAVYVFCNMTAEGETCVYPDIHSSQMPTIPWRKENDKTDWYSNLRGGFRISYETIGTVQMTFLRLLSQEAYQNFTYACMNSVAWYSTQDESFDNALRFLGENEIDIGYEQSKIKPTVLVDGCKTGRSKSETVFEIRTPKLQYLPIIDFYPVDYGLPQQAFGFQVGPVCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE76</accession>
    <name>A0A084VE76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smile protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003387</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE76"/>
    <dbReference type="STRING" id="74873.A0A084VE76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003387-RA">
        <property type="protein sequence ID" value="ASIC003387-PA"/>
        <property type="gene ID" value="ASIC003387"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003387"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013728"/>
    <dbReference type="OMA" id="IARNQDW"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003387-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="16140" checksum="2EDC54199EA0E4EC" modified="2014-10-29" version="1">MGCLILVVYGAQRLWERSVALRKPIMLLGVILLTAGTLKTIARNQDWSSREALLRSGLKTLPHNAKMHYNFGNFLRDSSQPEPAIAHYREALRLWPSYASAHNNIGTLMPQFATAEYHFREAIKYSSEHINAHYNLGQLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE80</accession>
    <name>A0A084VE80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A2M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE80"/>
    <dbReference type="STRING" id="74873.A0A084VE80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003393-RA">
        <property type="protein sequence ID" value="ASIC003393-PA"/>
        <property type="gene ID" value="ASIC003393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003393"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010213"/>
    <dbReference type="OrthoDB" id="7737616at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003393-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="15167" checksum="02F7368C18E9186A" modified="2014-10-29" version="1">MDPEFGLGIIKEPIEFTTVQSFYIVDNLPSSIKQGEIVALLFTLFNNLGGEYIAYVTMYNVGNQIEFVGQPAGASSYTKSISVKPKVGVPISFLAKAKKLGNIIVRLRASIMLGLEIDAVEKIVLVMPCTIRTDKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEL9</accession>
    <name>A0A084VEL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein At4g22160-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003580</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003580-RA">
        <property type="protein sequence ID" value="ASIC003580-PA"/>
        <property type="gene ID" value="ASIC003580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003580"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003580-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="20959" checksum="06747D1E43626EC8" modified="2014-10-29" version="1">MIGYDSEFVPFDSCPEAFRFEVLQNELPYWREIFSAERRASNQEKRQTETMLRRQGSESSAFENQPHRHQKRQDDRREDFLRASAGFWLTWCNGTDSTELARKEFVPRTTKDEDHSPSGTKDETNTLCIRHASRRKKPYGRPIVNMTLMSRTTRKRIKGMTTNRKDLSCDSPRPDSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEM6</accession>
    <name>A0A084VEM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003588</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003588-RA">
        <property type="protein sequence ID" value="ASIC003588-PA"/>
        <property type="gene ID" value="ASIC003588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003588"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11036" checksum="E4E333C7EFF09151" modified="2014-10-29" version="1">MATSPGGNAFRLGLFDKVMLGHKSPGLPINVGLARAIINRTLRYDFGPGSARIKAPRFIGLRPPEGPRESRLYLPSADAFPLPSFAFSLCTSGHHRPEVANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGL9</accession>
    <name>A0A084VGL9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524833">
        <property type="protein sequence ID" value="KFB37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGL9"/>
    <dbReference type="STRING" id="74873.A0A084VGL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004314-RA">
        <property type="protein sequence ID" value="ASIC004314-PA"/>
        <property type="gene ID" value="ASIC004314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004314"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015566"/>
    <dbReference type="OMA" id="RPKNAWS"/>
    <dbReference type="OrthoDB" id="10059330at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019373">
        <property type="entry name" value="Ribosomal_mL51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10244">
        <property type="entry name" value="MRP-L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="163" mass="19148" checksum="D30437B43929530E" modified="2014-10-29" version="1">MSLAGNILASITRAIWNPQITAVRFRYHADKVARGPLVRRYGYEDKILQRGLLPHLDNGQKLPMPDYKPKNAWCEKRALFGQNDYIDILGNDRLHPTRVLYSVPSWLRGVSGNEYQVLLRKRKILSRTIYPVARPTKWRDMEKRISYLYRFLNRKTKTGFSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHF1</accession>
    <name>A0A084VHF1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004694</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004694-RA">
        <property type="protein sequence ID" value="ASIC004694-PA"/>
        <property type="gene ID" value="ASIC004694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004694"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="16600" checksum="E7A5372BC3981F9F" modified="2014-10-29" version="1">MEPESKRGRQMNMIHYASFSLSHLQKNGGLRVRTRTLQPMTMVESGDKPATVRLNAAHPSWEKDSRKAHQHQQPYGRLVRPFVSLGIAHRKRASFDRVTLVGRFSTIQAESERGRVPFGGEVLRCAPENQDPHTGSRVWRIVRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHF4</accession>
    <name>A0A084VHF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004697</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004697-RA">
        <property type="protein sequence ID" value="ASIC004697-PA"/>
        <property type="gene ID" value="ASIC004697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004697"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12917" checksum="EBFCF07985512FBF" modified="2014-10-29" version="1">MFAAVCTRHLEEAEEGKRRLGRCPARPNPDWLSRVPRVRFKMSSDVGGSIPTPHKLRALTQRTVSNHGAQQNEGFASVIHLQENPISPVNGQRACAGIDFRLVWCRFIFDYDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI14</accession>
    <name>A0A084VI14_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001708-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GD_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524848">
        <property type="protein sequence ID" value="KFB37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI14"/>
    <dbReference type="STRING" id="74873.A0A084VI14"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004852-RA">
        <property type="protein sequence ID" value="ASIC004852-PA"/>
        <property type="gene ID" value="ASIC004852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004852"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018230"/>
    <dbReference type="OMA" id="HEYQRTI"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783410" evidence="1">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Serine protease gd N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="286" mass="30927" checksum="B6133AD856DDE057" modified="2014-10-29" version="1">MARAVLPCSWSVVLVSALVVLVLPGASDGASVGSAVSPCPAIFKYASDSIKQQIYGIVDTREQVVDKVGTLELHLSIAGELRSKYVGSIEAIEDSTQILEQFGKGRGVQYRVNFPLQDPLPKITKVIFNGRELCTGPGDRGTFVSAVTLRHFLRSDSCKENCERTKVVPSSLNLDLSPPAVATTTVRPAAFPVAAPIAAPVTPLGQRKQIQPLDKTKPAGESTAPGVQHEYQRTIERKEETNNPQDNSTSVKYIREEITYRKQVITPGGAATLQDDELQLPSFVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI64</accession>
    <name>A0A084VI64_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00004914</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524850">
        <property type="protein sequence ID" value="KFB37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI64"/>
    <dbReference type="STRING" id="74873.A0A084VI64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004914-RA">
        <property type="protein sequence ID" value="ASIC004914-PA"/>
        <property type="gene ID" value="ASIC004914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004914"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021900"/>
    <dbReference type="OMA" id="DINMFQR"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF61">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="808" mass="92574" checksum="780E22F238AF1E48" modified="2014-10-29" version="1">MGAMFRSEEMSMVQLLIQPEAAYQSVAELGELGIAQFRDLNADINMFQRKYTSEIRRCEEMERKIGYIRREIAKDGTVPIPDMPEEIPRTPNSREIIDLEAQLEKTENEIVELSENNHALLQNFMELTELKNVLEKTQVFFSDKSNVQNLEATGGEAANEGKPLGFVAGVISRERVIGFERMLWRVSRGNIFLRQATLEEALVDPKTGDSVHKLVFVAFFQGEQLKSRVKKVCTGYHASLYPCPNESNEREEMLRGVRTRIEDLKMVLGQTSDQRQRVLLNVAKEVPTWEIIVKKVKAIYHTLNMFNVDVSKKCLFGEAWVPTASLQDVKTALVNGSAAVGSAVPSFLNIIATDEVPPTYNKTNKFTRGFQNLIEAYGIASYREANPALYTIITFPFLFAIMFGDLGHGLILLIVGLWMVLWEKTLDKNKEEIWQLFFGGRYIILLMGCFSMYTGFVYNDVFSKPMNIFGSAWSNNYNTSTVMTNNELQLNPSEDYSETVYWYGLDPIWMLATNKIIFLNSFKMKLSIIFGVVHMIFGVCMSLVNHNYFRRRENILLEFIPQMLFLVLLFAYMCFMMFFKWINYSAVTDEDHLKPGCAPSVLIMFINMMLFKSQEPLDTCKEFMFEGQDTLQVIFIVIGLICIPWLLLAKPFFIMYKRKGKVGDVAEPAPQSSHGGHGHDDEPMSEIFIYQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLYTMVFHIGLQNDSYVGAIMIWLVFWPWSVLTIGILVGMEGLSAFLHTLRLHWVEFMSKFYEGLGYAFQPFSFKALLEEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI69</accession>
    <name>A0A084VI69_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP003430-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00004903</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524850">
        <property type="protein sequence ID" value="KFB37663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI69"/>
    <dbReference type="STRING" id="74873.A0A084VI69"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004903-RA">
        <property type="protein sequence ID" value="ASIC004903-PA"/>
        <property type="gene ID" value="ASIC004903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004903"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005721"/>
    <dbReference type="OMA" id="CDINFEQ"/>
    <dbReference type="OrthoDB" id="7866065at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056780">
        <property type="entry name" value="Renin_r_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012493">
        <property type="entry name" value="Renin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057318">
        <property type="entry name" value="RENR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351:SF1">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07850">
        <property type="entry name" value="Renin_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25294">
        <property type="entry name" value="RENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783694" evidence="14">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Renin receptor N-terminal" evidence="16">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Renin receptor-like C-terminal transmembrane spanning segment" evidence="15">
        <location>
            <begin position="247"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB37663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="34921" checksum="23F97E4874A4DA80" modified="2014-10-29" version="1">MLRAISLLFALFAAANCDQLSVLFTPKSVEFSGNSRLDSDSIPEVFGAALGYSVSFPSEWDGMVIKDPFNTANGAVVVVAEGLDSLPVEGAKSFDLIGNTGSVALSELIQKSADHHSVSFEVDLKESSDSFTTPLGTVQPDDDEVKPQHLKPKSNKADSDFLRQIAFINGLSDLLVTSTDSIPTVHVVRVSFEAILAAHESDAPALDEAKKLFVNALKSLETAAEKAFDGSVIVGLVTASEGQLVVRSKRQASQPKQEIDEENPMNLALKYNSNYPVMFNIILWFSVVLAFSLIAISIVIGTMDPGRDSIIYRMTSTRMKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIT0</accession>
    <name>A0A084VIT0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005191</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIT0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005191-RA">
        <property type="protein sequence ID" value="ASIC005191-PA"/>
        <property type="gene ID" value="ASIC005191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005191"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005191-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="14092" checksum="302B2E60A5037DC9" modified="2014-10-29" version="1">MTYLLRHAPIELSMQQPWGEGVGGVGSSRLNDFISGKSSRNPDRWTSRLLREEIDWRKRNGGWETGAKNGEQEMRRVAGDECPAIFRVRAKAPKKTIKDLQTINPLDYCTVERVLWKMTGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIW7</accession>
    <name>A0A084VIW7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005233</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013412">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIW7"/>
    <dbReference type="STRING" id="74873.A0A084VIW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005233-RA">
        <property type="protein sequence ID" value="ASIC005233-PA"/>
        <property type="gene ID" value="ASIC005233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005233"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019839"/>
    <dbReference type="OMA" id="QIVNHMV"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF80">
        <property type="entry name" value="GH17657P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="101"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="292"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="585" mass="64385" checksum="1C3E38AF561E2124" modified="2014-10-29" version="1">MPRKNVSIRVFPSTADVNQHRKFVAKRSVLSDATVTPPIGESRSQTGEAGYRCIEERQVLGIHGLLPAAVRTEEKQLEHCLALLEHYTEPLDKYIYLMGLADRNERLFYRVLGSNIADMMPLVYTPTVGLACQKYSLIFQQPKGLYVSINDKGHVYDVLKNWPEVDVRAIVVTDGERILGLGDLGANGMGIPVGKLALYTALAGIKPSQCLPVTLDVGTNTQSILDDPLYIGLRHKRVTGTAYDEFVQEFMEAAVRRFGRNCLIQFEDFANANAFRFLEQYRNDYCTFNDDIQGTASVAVAGLFASLRITKKRLSENLILFQGAGEAALGIAELCVLAMLRDGLSAAEARKRIWLVDSRGLIVKDRPTGGISGHKHHYAHEHEPVDTLAEAVERLKPTILIGAAAIAGAFTPAILRKMADHNPRPIIFALSNPTSKAECTAEQAYEHTDGRAVFASGSPFAPVTIGERTFYPGQGNNSYIFPGLALGVLCAGATTIPEEMFLISAMTLADIVTEEDLERGSLYPPLERIKDCSIKIAVRVMEYAYENGLATTRPEPQDKEAFVLTQMYDAGNKSALPVTYPWPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJH9</accession>
    <name>A0A084VJH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP009828-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00005414</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013571">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524868">
        <property type="protein sequence ID" value="KFB38123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJH9"/>
    <dbReference type="STRING" id="74873.A0A084VJH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005414-RA">
        <property type="protein sequence ID" value="ASIC005414-PA"/>
        <property type="gene ID" value="ASIC005414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005414"/>
    <dbReference type="OrthoDB" id="6358644at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="150" mass="16065" checksum="315E6058496561BD" modified="2014-10-29" version="1">MPETAPYIVAVREGSAFICAGVLIKSNWVLTTAQCINDKSQADLSILAGSHRLLTNKNLLLISDIVKHTEYNTASGAHNLALLKLAEPVTLSSRINIIPLNDTLVQRTLSTTDCRTSIASLADGDICALIQPGQAACTKDEGGPLLWYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKI3</accession>
    <name>A0A084VKI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP009010-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00005880</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKI3"/>
    <dbReference type="STRING" id="74873.A0A084VKI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005880-RA">
        <property type="protein sequence ID" value="ASIC005880-PA"/>
        <property type="gene ID" value="ASIC005880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005880"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013530"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016287"/>
    <dbReference type="OMA" id="NETHYIC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="509" mass="58192" checksum="F22B20BA4FCD987C" modified="2014-10-29" version="1">MENRLQITVRFQISEIGRDALSLCEECCKFVNKLERFKERCEETDRLFIYLSNFNNIEMSTRELKKIRSRYLGMSDLGDGADSNQEDIDSEAQHLTTAIEGIDHNEENAKGNSAEDPIATFVEFKVEQVEQVDTSTINITPERTASDTEQWEPNELEYEDDRSAEYSDPPSRDEKLEEIEAVSTEPMAEPQTSSDDVDKTSPKSSDALPAGERKGKRRTFQCGICLKTFNSCSLMKEHEDTHFPKHNLYFPDNEFTCPICDKKFRRAINVKAHVRLVHDGIKPFICEECGRAFGSKGALKEHYVVHSDARPFKCPKCPLTFKNQSRLKTHEDVHNETHYICPYCGLQLKTKRTLNMHMLVHSDLRKHKCEYCGKEYKRSKALKIHLILHTGLRPYQCQFCDQTFTNGSNCRSHKKKHHPHELAALEAAGGHAPASNIPKLESLKPKPKRARGSTVIIPETQDKTEEPDLKVEVVELAPIVETSNVKEKNTILNTSLKLRSKKKARRSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKW0</accession>
    <name>A0A084VKW0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005981</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A084VKW0"/>
    <dbReference type="STRING" id="74873.A0A084VKW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005981-RA">
        <property type="protein sequence ID" value="ASIC005981-PA"/>
        <property type="gene ID" value="ASIC005981"/>
    </dbReference>
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    <dbReference type="OMA" id="PKLYWHY"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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        <property type="entry name" value="JMJC"/>
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    <keyword evidence="5" id="KW-0408">Iron</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="62"/>
            <end position="204"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="23643" checksum="FA5891FE6F9BBF54" modified="2014-10-29" version="1">MERWHDPAYLLSIAGERTVPIELGSQYSSDDWSQKLMKFGEFVEQNICTDSPGPPTDGNRTAYLAQHDLFDQVPALRRDITVPDYIGRTDANPRIKAWLGPKGTVSPLHTDPCHNLLCQVFGSKTIILARPEDTDNLYPHEHFILSNTSQVDARQLDYERFPLVRQVRFRRLTLHRGEVLYIPPKWWHYVESLSPSFSVSFWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLF1</accession>
    <name>A0A084VLF1_ANOSI</name>
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            <fullName evidence="3">AGAP000437-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DM5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC006235-RA">
        <property type="protein sequence ID" value="ASIC006235-PA"/>
        <property type="gene ID" value="ASIC006235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006235"/>
    <dbReference type="OMA" id="TEEKTLX"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DUF243"/>
    </dbReference>
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        <property type="entry name" value="FI07246P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783829" evidence="1">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="2">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="25492" checksum="D43547D7AC53F550" modified="2014-10-29" version="1">MRAFVIFVACLAVVSADIGLDLQRGGGSGVSVDYVPTTYQDTSVGASADARSFGGAGGAGAGAGANAGAFGGAGGAGFGGAGGAGFGGAGGAGFGGAGADANARAFGGAGGAGFGEATANAEADTLTITPKKHYKIIFIKAPTLGANAGSNAYAASKTEEKTLXXXXXXXLDWCRRLVVSEVSEVLELELMRALVLEPELVVLDSEQALERTQLPTLMPSVDSVETVASAELVPTLALLLVLATLKFTKHSSTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLI5</accession>
    <name>A0A084VLI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006314</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC006314-RA">
        <property type="protein sequence ID" value="ASIC006314-PA"/>
        <property type="gene ID" value="ASIC006314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006314"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13896" checksum="2D60DF713B0EC027" modified="2014-10-29" version="1">MLINGRIENIAPDRKLPKRKVLHVLRGVTEYQPSPPPPPSPSQVGLPPPCCSKVFTVYRGGVRDSRIRCHKSGLLRDVRKRAEREHARRHENPIRCANIRSGHIGTIRRFTCICDKSVTDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLK3</accession>
    <name>A0A084VLK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000605-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014517">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLK3"/>
    <dbReference type="STRING" id="74873.A0A084VLK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006335-RA">
        <property type="protein sequence ID" value="ASIC006335-PA"/>
        <property type="gene ID" value="ASIC006335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006335"/>
    <dbReference type="OMA" id="QGFDACE"/>
    <dbReference type="OrthoDB" id="8023940at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783641" evidence="1">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="17751" checksum="25034EE4B26F483B" modified="2014-10-29" version="1">MNKLIVGSLFLLFAGHLTAGSMFGPFGPFAQQAGGAAGAGFFPGFPGRPVVGQLPFFPPQLPFFPPQQPFFPASPFAPAVAPAVGPAPAPALGRALPAPLALPAPLALPAPLAVPPTLPAAAGGSLRTVVATSDVLGRLAVADLPEDLQQRAQELQAASETGFNATSGAMRSSFATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLS1</accession>
    <name>A0A084VLS1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP000454-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00006236</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLS1"/>
    <dbReference type="STRING" id="74873.A0A084VLS1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006236-RA">
        <property type="protein sequence ID" value="ASIC006236-PA"/>
        <property type="gene ID" value="ASIC006236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006236"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016969"/>
    <dbReference type="OMA" id="IYAMWAS"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="9">
        <location>
            <begin position="294"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="11">
        <location>
            <begin position="493"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB38915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="622" mass="69205" checksum="B40B66CCA80975A5" modified="2014-10-29" version="1">MLRKTYIPLTRSLVRTYRSQCSFSTVASQESSNSSDAVPDSVNDLSKPAHVRLPKRSPFMKSMFLGTVDTELLTFPESLNREEQSRLTKHAEQVRDSLRPAGADTSFKSLDLLSLQGPLEYGGKQFIETELAYVSELMSEDRAAALVTLEHNTIVKILAQHGTDELKDKYLPKMCAGEAVAASALYEVSSSRQTMFSTVANLDFANRKWTLNGSKVLLRNDAADPNLLLVVASTKNMAQLNKEDGTVAVFLVDVQSKGVAISQSKIGSKGLSRVTVDFNHVELPEANLVGTEHGGAEIMTKFLSATRVQSSVVRVSLLKKILNSLTDFCINTKTSTGEMMDIEIVREQLARMASVIYAAESMIYMTTSLMDDFDSQDVEMEAAITKVFSADNLLKFATLPLQLLGPQALSAGNPFEGLFDDALKLFTGDESLDSVNFFIALTGLQYAGMHSYETIKKDRNPAMYPSHVLSKLFEKTSIEQPKKFANLQQFFHPSLDPAALWIEFSIVRLKLATECVLSRHGIEVIDRHVELGRLANIAAQIYAMVATASRASRSYCIGLRHADHEVHLANMLCRETSEKIRLLAIELEKGPYITSDDDYNVVARNLFREKRYFFEHPITKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM50</accession>
    <name>A0A084VM50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Conserved repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006756</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014578">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006756-RA">
        <property type="protein sequence ID" value="ASIC006756-PA"/>
        <property type="gene ID" value="ASIC006756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006756"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006756-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="12591" checksum="CE8A4EBA0F73AA7F" modified="2014-10-29" version="1">MFGVPGQGREGTIETTTGEGKAIKATATIVSPRDDHESIVNNYISRRPRQRSSSLAVSQRPAFRLQQATAKWAAPCADHGLATVFPTAAESRGNGETKMINAARSQKTEAREVGWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMG4</accession>
    <name>A0A084VMG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Bmp family lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006493</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006493-RA">
        <property type="protein sequence ID" value="ASIC006493-PA"/>
        <property type="gene ID" value="ASIC006493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006493"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13358" checksum="4222FC61D8539691" modified="2014-10-29" version="1">MECVCVHPSSPEARQSVAAPDFPPDLKLLGTGRLLWLAAECRKPLSPVRSYTDQGQSKALSSIRSIPFSQQVVPILMGYQDALTPQHHAHVSGKMSFMLSVSAFELPSEKRFCNLRTGVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMQ9</accession>
    <name>A0A084VMQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="24 25">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00006602</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VMQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006602-RA">
        <property type="protein sequence ID" value="ASIC006602-PA"/>
        <property type="gene ID" value="ASIC006602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006602"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000229"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002046"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004583"/>
    <dbReference type="OMA" id="CMINAHV"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033490">
        <property type="entry name" value="LRP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669:SF1">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="17">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="17">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="17">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="17">
        <location>
            <begin position="989"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="22">
        <location>
            <begin position="1492"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="21">
        <location>
            <begin position="1601"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="20">
        <location>
            <begin position="1715"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="23">
        <location>
            <begin position="1915"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1046"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1378"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB39253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2042" mass="227402" checksum="FEAEF2D46A605C18" modified="2014-10-29" version="1">MASILRSSKFVRYFAGFARNLVFNTARETESSFVQQTQCLCGNFTSGFATAAINSKSGLDRSLKRLDEDVRRSGRISRRDLEEVLEEIRINRSATSAQSLLVIRCCGNLVPEELPEVRTALVQEIWKTLKNLNVAMDVSHYNALLRVYLDNEHPFSPTEFLADMQSKGIEPNRVTYQRLISRYCQQGDIEGATKILEYMREKQLPVNEYVFNALIMGHSQADDLESATGILAVMAQAGLQPSADTYTTLLCGYARKGDIDYICKTMDACEQKEIFLLDKDILEVIYTLAANGHAERVDQLVEKIRRQAGYNQDAVNVILRLINKGQEEVGMKLLRTMPRASKNDGELANTGSFLVRQLVRAKRPAAKVIAMCRELQESGMNDRAFLIALETALKSGSVELSFELLQELSQQNQPIRQHFFWPLMCTSGDPAMTKEARTENVLYVLRSMTEKFNIYPSSETVREYAVPNLPVTNSDIVIQLLRSAGISSAVASSSCAYVALERNNLKEAANIASRYRAYYAPGVYRKPLVLALYQTRDYESYVRFVRSLYDGLKRSRSAEEESDQPVGGAVEGTEGAGTNSSSSVEAMQAETLGCIIYDALVTFKTDRVEMMQKILTGFVAQGLSISHGLAEKIQERMGGEMTAEISGLLSKLAAGDLEPIEMERERDRSQTTTANERGQRQKPASASLSIPQLERLIAEMENRKENTNSLKSQLIRSTIRANDVAKTTEVMERLEGENYVISPAIYGLVIELYATNGKLEEAFGLLKSVKAKQPDFVLDRVKVVRLAQGMLEAERFDEALQFLKENSKEEPPREEVDFVYNSACWRLLNILAEKGNVQQVNAMFDHLIGQGYIKAQNIFLGSLIKVHLVRDDLTAAMGTFADICQKYRMTPWKTELTCRLIQAEDATNLQRLTDLSTEVHGEVNSLYDLVFAFVDCGRIRQARKILETPGLRTRYARIQTACERYQQEGKTASLEGLMEATKDLSHIDRTEIYHKLLQSYIHEKDADKALGLWTRMQEESVAPSDAFMTELAEFLKTNGYEVPFVVPEPRPGARTKATKESSRVAPTSSTSTADRQQRTQTNPALRELKAAIKANDHDRVLAAYESMAAGTKLNLTEQSAIIESLVNRERLTQATKLVLEILEQKLFPIPRTFKFYLNKLAISGDVATFERIGTLISDDLKRQVSFDNRLCHANVSSGNAEQYLRRLEQALDRVQTKEEALLQSKHFPIGGASGILSQHPELHERYERLAERYAKWDLRAPINALWTHYFIVGDSERAGAIWDRHLKDSSRIMFQKIIQQARDTKNEALCRRLIDALRDSQVAEKGKGLIYSCLIDILIANGKPEEALVALDEGLKMTCLENINRTALKRLQEGLTAKGKEFPHTIPAKQSGKAREPSSTSSSDSDSESSSDEEAKKAKAQPPTTSSSPKLSCLSAAPQVKRAEQAAAPVEADKQRPNMSFLTNIFRGEVQPAQVFPYPEALDAEQKEYIAAFVDPVTKFFEEVNDPVKNDANASIDEKTTEALWELGAFSLQVPPEYGGLGLNNTQYSRMCDIIGGQDLGLGIFIGAHQSIGFKGILLYGTKEQKEKYLPKVSTGKTYAAFALTEPSSGSDAGSIRCRAVKSADGKHYVLNGSKIWISNGGIADVMTVFAQTEIEDPKTGQKKDKVTAFIVERGFGGVSSGPPENKMGIKCSNTAEVYFEDVKIPIENVLGGEGNGFKVAMNILNNGRFGMAATLSGTMRACIQKAAEHATNRVQFGRKIETYGGIQEKLAKMAMHHYATQSMAYMISGNMDTGSQDYHLEAAISKVFASESAWYVCDEAIQILGGMGFMKDCGLERVMRDLRIFRIFEGTNDILRLFVALTGIQYAGSHLKELQRAFKNPATNMGLIFKEGSRRAIRSIGYGGTDMSAYVAEPLKVSAKQCSECIDLFGQAVESLLIKYGKKIVDEQFLLNRLADAAIDTYSMAVVLSRASRSVKKDLPSAEHEVLMTKAWCHEASDRVRVNIRKINNESFVKNYGIMSQISKNICANNGIAHNNPLDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNH9</accession>
    <name>A0A084VNH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP009626-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006865</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNH9"/>
    <dbReference type="STRING" id="74873.A0A084VNH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006865-RA">
        <property type="protein sequence ID" value="ASIC006865-PA"/>
        <property type="gene ID" value="ASIC006865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006865"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019860"/>
    <dbReference type="OMA" id="YICTTEL"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000083">
        <property type="entry name" value="guanylyl cyclase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783612" evidence="4">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="16825" checksum="2183B98283921746" modified="2014-10-29" version="1">MLFCAKIYCLAFLFTSSGQYAHYVFNSIDLDRNGSLSFEEFVANLSILLRGTVDEKLQWTFSLYDINGDGCITKEEMKEIVTAIYELMGKVPEGCEEEQAIKEKVERLFEKMDRNCDGMITLDEFIECCTKDESIRRSIAVFDTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNP2</accession>
    <name>A0A084VNP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007035</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014799">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524989">
        <property type="protein sequence ID" value="KFB39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007035-RA">
        <property type="protein sequence ID" value="ASIC007035-PA"/>
        <property type="gene ID" value="ASIC007035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007035"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10437" checksum="2FAA6EA86C90AF11" modified="2014-10-29" version="1">MAPGRTALSSAFVGVRFASSKAGVTAFNLDDTNSNYSGTPSIRKKSFQIYSGAGIVPKAPEVNAFAPSLTPFGSNRNLLTFWQQGRRLSPFRHVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNU6</accession>
    <name>A0A084VNU6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 1-gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eEF-1B gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524996">
        <property type="protein sequence ID" value="KFB39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNU6"/>
    <dbReference type="STRING" id="74873.A0A084VNU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007087-RA">
        <property type="protein sequence ID" value="ASIC007087-PA"/>
        <property type="gene ID" value="ASIC007087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007087"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010014"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000233">
        <property type="entry name" value="Elongation factor 1-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="7">
        <location>
            <begin position="268"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="427" mass="48594" checksum="1F823A58D2D94D9F" modified="2014-10-29" version="1">MAGTLYTYPENFRAYKVLIAAQYSGAAVKEASEFVFGETNRSDAFLAKFPLGKVPAFETKDGKYLTESNAIAYYVANEQLRGTSDFYRAEVQSFVSFADNELLPAVQSWVFPVIGIVPYNKNNVERAKEDLRRGLAVLNARLLKQTFLVGERVTLADVVVFTTLLHAYEHVLDPSFRAPFSAVTRWFSTIQNQPQVKAVVKAFTLCAKIAQVDPKKYAEFQAKLGGGSAPAADKPEKKKEKKEKKPAAEEPAEQPDAAEELLAAEPKQNDPFETLPKGTFNFDDFKRFYSNEEEAKSIPYFWTKFDPANYSIWYGEYKYPEELTKVFMSCNLITGMFQRLDKMRKQSFASVCLFGEDNNSTISGIWVWRGQDLAFKLSPDWQVDYEVYDWKKLDPASEETKKLVAQYFSWTGADKDGRKFNQGKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPG4</accession>
    <name>A0A084VPG4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00007231</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01015003">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015004">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPG4"/>
    <dbReference type="STRING" id="74873.A0A084VPG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007231-RA">
        <property type="protein sequence ID" value="ASIC007231-PA"/>
        <property type="gene ID" value="ASIC007231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007231"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020046"/>
    <dbReference type="OMA" id="HTWVNGT"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="181"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="273" mass="29441" checksum="C055A6D4B2C982D4" modified="2014-10-29" version="1">MVAKGDVFGPNQPLVLHLLDIPPMMGVLEGVVMELADCALPLLVSVVPTADPAVAFKDVDAAFLVGAMPRKQGMERKDLLSANVKIFKVQGEALDKYAKKDVKVLVVGNPANTNALVCSHYAPSIPKENFTAMTRLDQNRAQAQIAARLGVGITKVKNVIIWGNHSATQVPDARNASVEMSSAMSAAKAASDHMRDWFAGTREGEYVSMGVISDGSYGAPKDIVFSFPVQIQNRQWKIVQGLSVDEFTRSKLDVTAKELLEEKEEAMAVCAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQL3</accession>
    <name>A0A084VQL3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003293-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00007720</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ATLV01015250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525004">
        <property type="protein sequence ID" value="KFB40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQL3"/>
    <dbReference type="STRING" id="74873.A0A084VQL3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007720-RA">
        <property type="protein sequence ID" value="ASIC007720-PA"/>
        <property type="gene ID" value="ASIC007720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007720"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016924"/>
    <dbReference type="OMA" id="LRFDNDM"/>
    <dbReference type="OrthoDB" id="434989at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF133">
        <property type="entry name" value="POLY(A) RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="183"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="630" mass="71086" checksum="A211B8FC1D7AEAA4" modified="2014-10-29" version="1">MFHIYRTTVRSRRTPVVGHFRRILLPPGRIAFPRPSWPVRYCSANVRTFDTMLSARRTQARRSILVQVSSERSYNELYHYCSQFGNIETAHHYRVDGDSDGDCHYILLEYSSTSEADAAMQSGVFSTERPGVRARSIFMWFRTGPKPKLVVQEEPKRPLALIDGTRSIDDADLNGLLSAAETIDDQVKVLHRVTMLNDLGKRLRFLAVRQLESSLQGMFPQAVAHPFGSSVNGYGRMGCDLDVILDLDSRSGEPPDRNSRLVYHTKATNPNERTQVQRQLESIGDVLQLFLPGVNSVRRILKARVPIVKYHHEHLDLEIDLTMNNTAGVYMSELLYLFGQLDERVRPLTFCVRRWAQSVGLTNQAPGYWITNFSLTMLVMYFLQQLKTPILPSINKLIQLSAASQPQESLSLTRFADSGEAGWALAFLKNPTIYRSFRSANTCTLEQLLVQFFEFYSAFDFSQRAISLNIGGSILKPDHSPMYIVNPLETVLNVSKNVNLEETELFRMQRTGRMAAAAAAAAAAEPWGLVSLFGPKQQERITPQMFFTKRMLNVKDIFDDVPTDEPAENQRQQYRNPAVKSQIAAIQRATKVEISKLSTGARPGAASTTDARAATIEGTGVKLKRNTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR06</accession>
    <name>A0A084VR06_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007176-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007876</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015367">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR06"/>
    <dbReference type="STRING" id="74873.A0A084VR06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007876-RA">
        <property type="protein sequence ID" value="ASIC007876-PA"/>
        <property type="gene ID" value="ASIC007876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007876"/>
    <dbReference type="OMA" id="AVRDFFC"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000064">
        <property type="entry name" value="Blast:Sorting nexin-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="267"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="459" mass="50467" checksum="0BDD3992A5BDC115" modified="2014-10-29" version="1">MSLRAIQKRDREKLSSSQRQQFISHQQQLLGPGVGAMHGGGSDATTNTTTTAMKMTARSHYPDGPMMVVDGSSPAVPSVQSIIQNQNAKRNQKGGVAPGNTLLSRSQSTLRRSSSYPTLGARGSPSNTRSSGLRSIKSEGDLCAGNRRHHEGRGSAEEDGRSGGVARSSGGSSFSTNNLYLGAKSEVCLKTLAVKNMQQHHSVQLFPNGSAGPGSVRSSAGGASCTTTQQPSKRLYESRRTSELSSSDFGPANNKAELLHHKANNHGSAVRIPIVGYEVMEERARFTIFKLRIENSISHTCWLVLRRYTDFVRLNNKLKTLFPHCTLVLPRKKWFGDNFSSGFIDNRIQGLQTFIDTILGDDLMRSCTAVRDFFCLDEPPSYSESMEESRVIFEAQEETISQLKQQLQTKEDLVSVLQTKLATEQNRNKILSNVIRNNTENCAKCSKAIDQLLKESVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRP5</accession>
    <name>A0A084VRP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001822-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008211</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRP5"/>
    <dbReference type="STRING" id="74873.A0A084VRP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008211-RA">
        <property type="protein sequence ID" value="ASIC008211-PA"/>
        <property type="gene ID" value="ASIC008211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008211"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007876"/>
    <dbReference type="OMA" id="HWTESEG"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF167">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="405" mass="45087" checksum="E4E5AC2EBA71786A" modified="2014-10-29" version="1">MGKDKTKNKSSKHIKCDVQFDDNPQGIFRAGDTVSGTIEIQLEKPKKCRGIALRINGFASTSWHAKVKGPDDKGKTKNKKTNFNGREDYFGSITYFVGSDVGNPLEVPAGVHRYPFSCVIPQTAPSSKEGKYGHIRYVVKVSLERPWKYDHVFQVPFLVKSHADLSVAQDRMLLPTKAEMVQSFYFGLTDPLIVTASTPRTGYAPGEVIEVTIHVNNQSSVDVRGITIKFQRIDTFISQVPVVQQHLEHTVMEERTIGRVARRNDAVFEENILIGSTVPSDDERCKIIQTRYEVELLVRPVRSRKKMILTLPLVIGSVGLPSTLYPMQMLAKERAALGMDGPMGVEGALPPESPPPYPDDGQPSTSRAFLAEDSTPTAPVPDDAKEHEFEKGSEPYTPRDFDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRQ6</accession>
    <name>A0A084VRQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Iron-dicitrate transporter substrate-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008265</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015765">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008265-RA">
        <property type="protein sequence ID" value="ASIC008265-PA"/>
        <property type="gene ID" value="ASIC008265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008265"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="5986" checksum="55553D1BB639A115" modified="2014-10-29" version="1">MAGNNLAMIHASSTLPTRAEDYSGAKRSANMAGQHREGVMYATQLNIDIVALLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VST1</accession>
    <name>A0A084VST1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008642</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VST1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008642-RA">
        <property type="protein sequence ID" value="ASIC008642-PA"/>
        <property type="gene ID" value="ASIC008642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008642"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="10920" checksum="2D2EF91CB7D83C47" modified="2014-10-29" version="1">MSDLSSPGESPLLLGRGGERSTSTIFSFRQMKVKISLLQPSVDVGTAKSVVSLGNTVRSVERIPEGRPSPETTAKTPTVAAASTIATRRVPQFAAAGIGARKPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTD8</accession>
    <name>A0A084VTD8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008802</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016349">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTD8"/>
    <dbReference type="STRING" id="74873.A0A084VTD8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008802-RA">
        <property type="protein sequence ID" value="ASIC008802-PA"/>
        <property type="gene ID" value="ASIC008802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008802"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013492"/>
    <dbReference type="OMA" id="ARKIKTM"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783770" description="Guided entry of tail-anchored proteins factor 1" evidence="11">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008802-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="18608" checksum="F2FD81108AE98832" modified="2014-10-29" version="1">MYLIFVISILCLLMAFASKISKTVLPFICGDSAEVKSLKKEISQLRADLAKISMRDEYIKYVKCERTVVAYETKLNEAKGRDNVKRVVYEYAIHYGGMAVLALCMMYISFSYRYSTIIVFGSNFNFEPFGGLINFPAKVPNSISVVFWIVVNNFVARTIAGYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU81</accession>
    <name>A0A084VU81_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP004576-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ZHAS_00009130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016683">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525102">
        <property type="protein sequence ID" value="KFB41525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU81"/>
    <dbReference type="STRING" id="74873.A0A084VU81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009130-RA">
        <property type="protein sequence ID" value="ASIC009130-PA"/>
        <property type="gene ID" value="ASIC009130"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009130"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007765"/>
    <dbReference type="OMA" id="QKEYGPP"/>
    <dbReference type="OrthoDB" id="6376010at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF13">
        <property type="entry name" value="TWEEDLEBETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF243" evidence="2">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009130-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="198" mass="22112" checksum="514D96E692B1850E" modified="2014-10-29" version="1">MVILFACVVCAIARPEPEPPRARIVVPAKQQQLPQYEYGAPKPEYGPPAEEYGPPPPTVYGPPAREYGPPPKLITKNVYVHVPPEEPTEVIKSQVLEAPIPKKHYKIIFIKAPAPPAPIKQVIPPQPQDEHKTLVYVLVKKPEEPAPLEIPVPETTEPNKPEVYFIKYKEGEKEPHKQYGPPSPSYGPPSGPARYQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU85</accession>
    <name>A0A084VU85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00009143</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU85"/>
    <dbReference type="STRING" id="74873.A0A084VU85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009143-RA">
        <property type="protein sequence ID" value="ASIC009143-PA"/>
        <property type="gene ID" value="ASIC009143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009143"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021504"/>
    <dbReference type="OMA" id="NSTDFRH"/>
    <dbReference type="OrthoDB" id="67059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054091">
        <property type="entry name" value="Cep192-like_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054092">
        <property type="entry name" value="Cep192-like_D6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF14">
        <property type="entry name" value="BCDNA.LD24702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22074">
        <property type="entry name" value="Cep192_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22076">
        <property type="entry name" value="Cep192_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="2">
        <location>
            <begin position="711"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="3">
        <location>
            <begin position="824"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Cep192-like" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="383"/>
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        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF22074"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV30</accession>
    <name>A0A084VV30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009663</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009663-RA">
        <property type="protein sequence ID" value="ASIC009663-PA"/>
        <property type="gene ID" value="ASIC009663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009663"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11863" checksum="AB38EA4EB1A13261" modified="2014-10-29" version="1">MVTTQKPTHTNQRRSGSASEEVRQRMLRIRFDFTTQVAAVSTKILMPNSCRLLLGVSVIYFLPDTFRRQRTKRRTAGKNPLSISRRDRGYEAEALIFYVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVA0</accession>
    <name>A0A084VVA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005336-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVA0"/>
    <dbReference type="STRING" id="74873.A0A084VVA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009453-RA">
        <property type="protein sequence ID" value="ASIC009453-PA"/>
        <property type="gene ID" value="ASIC009453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007448"/>
    <dbReference type="OMA" id="NFRCNEP"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17674">
        <property type="entry name" value="SWIB_BAF60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated regulator of chromatin subfamily D member 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038041">
        <property type="entry name" value="SMARCD1_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="505" mass="57640" checksum="F53641C0B1FF7725" modified="2014-10-29" version="1">MAQRFPPAGGMPQRFGSPGPSSAPVMRPYGAQPNTYGVRGYSPQPPMGGPPPQSQHLHQRPMQAGYQGGNMRGSPMAGSSGSGGKRGADRNASQHKPGEYQAKKKKKLADKILPQKVRDLVPESQAYMDLLAFERKLDATIMRKRLDIQEALKRPMKQKRKLRIFISNTFYPSREPADGVLDPAQQMGGDASGLVASWELRVEGRLLEDGSKNDPNKVKRKFSSFFKSLVIELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGDRNVRCTILLLLDYQPLQFKLDPRLARLLGVHTQTRPVIISALWQYIKTHRLQDAHEREYIVCDKYLEQIFGCQRMKFAEIPQRLNPLLHPPDPIVINHVITVEGSLDNKQTACYDIDVEVDDSLKNQMNSFLMSTASQQEIQTLDGKIHDTVETINQLKTNREFFLSFAKDPQTFIHKWIVSQKRDLKAMTDVVGNPEEERRAEFYYQPWTQEAVSRYFFTKVNQKRAELEQALGIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX05</accession>
    <name>A0A084VX05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">GSG1b salivary protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010234</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010234-RA">
        <property type="protein sequence ID" value="ASIC010234-PA"/>
        <property type="gene ID" value="ASIC010234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010234"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004639"/>
    <dbReference type="OMA" id="NEYYAPM"/>
    <dbReference type="OrthoDB" id="7734137at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759918" evidence="1">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="367" mass="41971" checksum="C3C9F19F5A37E70F" modified="2014-10-29" version="1">MRFTAACLLLALLLATRVEASLRNNFAPQPSTFCQAPGENAVLPSDFHAACKRHSEGERDKLTHAYEVLLKHVAGLMSETDPVNTVVKSFLNALGSRRLTLANGPNEELRKSTMVAAIESGRSAEAMTLYLETRGWEDWRSVVDRIFANPRRHRQHIENLIAFIGMLPAREEQLDYLHHLRGPLVTHQYHEGYLGALFASGARRLVFADDGKTVRNQTDERLLWTTMVDASAGYFKRIFLSGSNLFELVLLDRDFPDAFTMLLPTVVNVTKDDLRYLDAWKMVEVPCEMHRSVSKLMMFEGMILMLQRHFTWDNQNHIHARFLAKRFKDCLPKFGKDAESQKLIKSTKELFGKFANRVTYETLIKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX80</accession>
    <name>A0A084VX80_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010288</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01017857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX80"/>
    <dbReference type="STRING" id="74873.A0A084VX80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010288-RA">
        <property type="protein sequence ID" value="ASIC010288-PA"/>
        <property type="gene ID" value="ASIC010288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010288"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007085"/>
    <dbReference type="OMA" id="CEREGND"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="40"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010288-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="565" mass="60567" checksum="F560C399D37A69B7" modified="2014-10-29" version="1">MESEKLLMAAGVTAAVVVGAFVFWGPSGSSKLRQRRGQIAGLHNFGKTCFLNTLLQALAACPQFIAWLQLHNTKDKKSLVSSLQNVLEVVNGTHPTLRGDPYAPGAVIRALHALGWVISPEEHDAHELLLVMLSSLEEEVSKPRKIGCLSDALDDIGGAVRGQGGDGAGGGDGASGFHPIPARPSSAMLSDFCNAEYDESTILTRYTRSEAHTPDSPHSVCTENEEQSQDGSLLEFGASPAHTISAAFAGGVGRRFVDGSRVAMPPPLRQAEAEARAEAGGFGAGKRHSASYRSLERLNRGPGRVSVWGDKQHQQIPHPFRGGMGSQLQCGGCGYKSTVRYDKFDSITLPLPETAAPGLGIGNLLSDFIQPEMLDAVQCESCHETTTHTKTITFSKLPACLCIHIARTTWLASGRAHKRLDSIHFPETLSMAPYSFVQPGLNSNISTPWGSTTSLYTAGLVNLSQPDGGDGGAGNDGAPGSSMTFGSYTFGAMFPRNLYRLLAVIVHSGEANAGHFVTYRRGALRNSYKWYYTSDTVVREVPIEEVLNSSAYMLFYDRGSSSKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYA6</accession>
    <name>A0A084VYA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP009050-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00010823</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYA6"/>
    <dbReference type="STRING" id="74873.A0A084VYA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010823-RA">
        <property type="protein sequence ID" value="ASIC010823-PA"/>
        <property type="gene ID" value="ASIC010823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010823"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004405"/>
    <dbReference type="OMA" id="ECEPQTR"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000002">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="410"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="552"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="597" mass="67384" checksum="D7A1A8D8F68F1288" modified="2014-10-29" version="1">MGRIPSIPEPSSGRRSKLSSLRRSLNALRCRISKRGRSKPPDQFLDKFSAASATSDTRLHQAGCVAPQAVPSDGVCSRLSVDPSLPSHYRWLSLVSLAVLYNIVFVIGRAVFWELNKQAAVLWWILDYLCDFIYLADTLVHCHEGYLEQGLLVRDASKLRKHYFSKQRWWLDVVSMLPTDLAYIWWAPSSCAATRLPCPIIVRINRLLRLPRMWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACLYFAISYALGFSTDNWVYNINGPKNLTLSRQYIYSFYWSTLTLTTIGETPTPENDAEYLFVVADFLAGVLIFATIVGNIGSMISNMNVTRVEFQNRMDGVKQYMAFRKVGGELEARVIRWFAYTWAQSGALDEERVLAALPDKLKAEIAIRVHMDTLRQVRIFQDCEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGSLSVVADDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSIGYSDLFCLAKRDLWETLADYPEARASLTERGCQLLRKDGLLDEAVFANAQQTQDSLESGVARLEQTVENLNLRLARLLAEYSASQAKLKQRISKLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZW1</accession>
    <name>A0A084VZW1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00011316</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525258">
        <property type="protein sequence ID" value="KFB43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZW1"/>
    <dbReference type="STRING" id="74873.A0A084VZW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011316-RA">
        <property type="protein sequence ID" value="ASIC011316-PA"/>
        <property type="gene ID" value="ASIC011316"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011316"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024475"/>
    <dbReference type="OMA" id="ILVSICN"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W021</accession>
    <name>A0A084W021_ANOSI</name>
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        <submittedName>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        </source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="346" mass="38539" checksum="FD4F841DCED714CE" modified="2014-10-29" version="1">MPEHLELQQLVDGVIQGTTRHHSLSWLRCSCPYIGIILATVSSFFFSLCSVIVKGLVDINPIELATFRFIGVLLPSIPIAIYREENFFPEGKRIILVLRCFVGTTGLMLSFYAFRHMPLADASVIIFSTPVFVAIFARLFLREACGMFNIITIFLTLIGVVLITKPPFLFGDNLVTIIDEQVMESNYDIWGPVAALSSTLFGANAYVLLRALKGLHFSVIMTNFGSFALIYTLVVCYYIGALCWPLCGMDRFLVVALALFSFGGQILLTLALQYEQAGPVAIARSADIVFAFVWQIMFFKETPSLYSILGALLVVSSVVLSGLRKWALALPRDSETRKKLHFLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W049</accession>
    <name>A0A084W049_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001239-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ZHAS_00011530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W049"/>
    <dbReference type="STRING" id="74873.A0A084W049"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011530-RA">
        <property type="protein sequence ID" value="ASIC011530-PA"/>
        <property type="gene ID" value="ASIC011530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011530"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021320"/>
    <dbReference type="OMA" id="MWTTDCP"/>
    <dbReference type="OrthoDB" id="6427221at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001107">
        <property type="entry name" value="Defective proboscis extension response"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF41">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784093" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="277" mass="30684" checksum="FBAB04C96A8D0BB4" modified="2014-10-29" version="1">MLTWLILPIAVLNIISGEVQSYWEQPFAQPYFDNSTKREITATVGQSALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHTEGSDEWTLRITSPQPRDSGTYECQVSMEPKISQAFRLNVVVSKAKILGNSELFIKSGSDINLTCVALQSPAPPSFIYWYKGGRVVNYSQRGGISVLTERQTKTSKLVIARAMPSDSGNYTCSPSSSDSASVVVHVINGEQPAAMQHGNSSANSILINNRSFSRRGRHLHRPGVLDLVGWLDHVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W177</accession>
    <name>A0A084W177_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00011852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01019240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB43971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W177"/>
    <dbReference type="STRING" id="74873.A0A084W177"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011852-RA">
        <property type="protein sequence ID" value="ASIC011852-PA"/>
        <property type="gene ID" value="ASIC011852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011852"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004256"/>
    <dbReference type="OMA" id="GNSCYML"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19218">
        <property type="entry name" value="SET_EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044439">
        <property type="entry name" value="EZH2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="14">
        <location>
            <begin position="501"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="608"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB43971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="742" mass="84724" checksum="439579E397756264" modified="2014-10-29" version="1">MSKYKVSLEWKKRVKTEYMKIRQSKRHKKVDDVRSAWNRNRQKLLDQLVKENDTWLSTNATWTQCDVEQLPHVGCMKKAETVDQDGNHQSVPIRVVNAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDQDGSFIEELIKNYDGKVHGDKEGSFIDDAMFVELVHALMVVTAKDAADEPDGKKLHSRASSSGETIDTSKADESLRKSKLKKTEKNNESETNGDGTERDDGRQIEHSTDGGNDLPSAKAFPAPIIFQAISSQFPEQGSAEELRDKYIELTERVDPERPPECTPNIDGQRAESVSREQTLHSYHTLFCRRCFKYDCFLHRLQACHPGPNLQRRRWPELKIPSKPCSETCYLLLDGMKEKMAADSSNKSVATMDSGNEASSEDSNDSSRYSKDAPFNKAMKNGASLLELFDPKDNGWNGSDKSFFRTLQKTYLNNFCAIAEAMLVKTCQQVYEFAQQEAADFMPIELNKDNTPPRKKKKKHRLWSVHCRKIQLRKESSSNHVFNYSPCDHPGQCDSNCPCYGAQNFCEKFCNCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQTCGADHYEINKITCKNVSVQRALHKHLLMAPSDVAGWGIFLKESAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVNGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W178</accession>
    <name>A0A084W178_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004686-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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                <person name="Ye Y."/>
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                <person name="Zou P."/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="163"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="299"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012003-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1402" mass="153153" checksum="2F4470A530039A2E" modified="2014-10-29" version="1">MAHSLGGPFRVTAHLSLDAYVNSLRRFSHLPGRLLVAQANGLQGYYGTKIGDLTELHHGVSGSVYAVDARTLFLKNFNYDGEGPAAYFYVGNTRAPSNKGAHRLRDERGRAGVLRRYRNEDITLSLPEGKTLRDIRWFSIWCDDFSVNFGDVQIRNDLDFPRPTKIAGLSGVHDVSSDNIVIVDAQTLLVPNFSYDGEAPDAKFWVGRGAAPTSQGIRIPDENGKETPLRRYDKKTIVLTLPGDLTVFDIGHFGVWCEAFTVDFGHVRIPDQINVPPSLKMLGISPQSKLNCEVLLDDLAFEVRWAVAGESVVVQLVAKLDDGEYMSFGVSPNPQQSQMIGADVAVVWVDKATGKGYAQDYYLDAKSQCSGGRGSCPDTRITESSNSIRLLNAAMVNGYSIVTYQRPLRASDHLDLPIFTNASQAIIWAVGPLNQRYEVSYHSHYLKGTKLVDFGRQPYWNCPTPESDQNRGTPEPAYGGPQSPQKLASSSNYGGGNRREDVANSVQQQQRPQAPATARPPAKAGAWDIPPIQCYEPEDGVFYAQLGPTGGKQGYPAITGHVGWGISWYINGLLIPEINVVRGKTYTFVVEGGLDSNVPAKYHPFYITDDSVGGYEHQSEEDRKNIRIFAGVHRSRSGKLVPTGVGRLCNWTPNPDGPPADEYPSFGAYQRSLSLKCDAGEPGIITWTPDADTPDTVYYQCYTHRYIGWRINVHDACDVAQPSELDEVYVEPNEGISVEESIRHESKVLPADNFLQQHENFLQKHELDLIKHHKMNPDAPKPDQAGLFDVNLEEHPEMTRIIEDGIRAAEELEEKLRSNQTAGLEGGVNQTIAHQHVHHHHAHHHGPPPPPGHRYPPGAPHHHGGSAKPILSSSGLPVYLRPPNGGPMFRPVKLPVRRPIGMERRPVAGSRPTRPFVIPQPSMIVSHYQKPVAPLMRPFVNKNKIPMKAIAPILLLGEPTEIKPPYRKGPAVEMMVAKPPKQVGGVEQQRPPNGQQSPGGPPFALPDMPPHLTMSLKKNEPVPITLPIRHTKPVKDTHKPNIKPIFKTAAYESVPHGESKGPYEGLAANHGFEPSSVVVESGFRPIYRRKDDYDLEFEDNRAHDHGFQRRQDDDIDEAIESDALMIHGQDEPIRQTFEPMFIPSPLDSMAMAHVKTSASPSSGPSRESATKRNVEILPDETADVVEADEDSLGAAANVRVDPFYLPPIAGSEGSVVAFDGKAVLDVSLLGSAPGDAADPLPPVGSPGSSKTEQLVRDTPQFGPFRGEIPPIAAYLAPDTVAIYGTRGSNAVQPPVSEYANPLLPGGINAQADGGGASGEQLGSLASAKPISTKLSIVKPMGAQESAEESSSGRARSKRSPHHHPDHHGDSHDDGWQPPQTSAGSRSWSSSLLLFVAPAILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W251</accession>
    <name>A0A084W251_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001375-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012164</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525273">
        <property type="protein sequence ID" value="KFB44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W251"/>
    <dbReference type="STRING" id="74873.A0A084W251"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012164-RA">
        <property type="protein sequence ID" value="ASIC012164-PA"/>
        <property type="gene ID" value="ASIC012164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012164"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017252"/>
    <dbReference type="OMA" id="EFFFMTN"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF292">
        <property type="entry name" value="SERPIN 100A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="67"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="607" mass="67802" checksum="ACC75A1B1895447F" modified="2014-10-29" version="1">MRNRAAIMKQTGRDRAVQYIRLGNALVLLLTVIVGVTVTPACYGLPKQRFSRDGGEPRSLVGIATNIITSSLLKGAPEINGNHVFSPIGFSSILAMISEGAEGQTLKELYDVFKFPTDRDLVRKAFDVSLKRLSGPNPTNEPQFKTWFYIYKNNSVLQAYKDVLEQSYGVEVRDIERNDYNFDEPKTSLGSIVDEEEEIIEESNGLDGDELAITEQAPTNNSNSKDIVDFEVLKIKSALPVEDELRTDTGISTKYDEVDDENPKFDKNIDDKEYVDPTKIKEELAKKKLEAMNEVVADTELSGSMVKLASDVDVTKTQPEKISLPLKKLGLDDEQEVLQAVESQGSRRKFNVRRSFLTGDIASALSGNSLVGRKANAKADDTEVNESKMLLFNGLYYRGSWETPFQQLRTEKNTFFTNTDEKPVMMMRSRGNFGIGKDDQLDAKFIELPYNNSRYSLLLMVPNTKDGLKELIKNFNPDTLSTVQKSLVQMSVQISIPKFRIDTTSRAEKSLAKLGLITMFTSKADLSGITPEQKIHVDELVQHVSIRVDEGSSSENALSATNAIEAKTVDDDQELFIADKPFLFFVRDIVDDIVIVAGKITDIPYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W282</accession>
    <name>A0A084W282_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005183-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00012205</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W282"/>
    <dbReference type="STRING" id="74873.A0A084W282"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012205-RA">
        <property type="protein sequence ID" value="ASIC012205-PA"/>
        <property type="gene ID" value="ASIC012205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012205"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021991"/>
    <dbReference type="OMA" id="PDCYSLA"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
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            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
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            <end position="310"/>
        </location>
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            <end position="325"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44326.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012205-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="534" mass="57306" checksum="3C4C85905F86E736" modified="2014-10-29" version="1">MKTKKHSPGHIKRPMNPFMVWSQIERRKICEVTPDMHNAVISKNLGQRWKQLSAAERQPFIDEAERLRQLHTREYPNYKYRPKKKQVKGTPHKTVAAGSGSPSPASSSTSTGSPESASSRDSCGSSSSSSSSSTSSLSSQSPLAAATPTGKSTTQTSSKRNRTTSGKVSKGGSYTSTTNLKSKKQVIIHEVGQPTMAAVATAATVTTLAAQPDCYSLATPKLLPNSPESATLYDENSLISPEPPFGAFSDGIGAFTELHMFEVDDSKDFDGKAFLFANGAGGLTDSGSATGNNGNNNNNTTTSTSSPNDSMRLGNMSASCNSPLPQHQTHHPQSNHSNNNNNSLQINNNHLQQQQQQHQLTSEDKLFECQQQHQLSPQQSICYSDTDGDCVKSEKYYDDDDCQSDRFGGILDGDSCLDAVSGINRIDESLDLGVSTGVSNGDGAGASGFDEMASHRRWTGSRPCRSCWPTATSTTTAKRTICPSWTGCSATPTMDGLGFEAMETASSSSGSHLEFITNDSSIFLTEQNLIEYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2W3</accession>
    <name>A0A084W2W3_ANOSI</name>
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        <submittedName>
            <fullName evidence="1">AGAP006930-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012437</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="7732202at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="22376" checksum="CEF69CD109046216" modified="2014-10-29" version="1">MLKTVFPFPISSMHTAANKTYDMPALVCLLCATTVRNFFDFSQKVAAVQKQLEKETVGSDDSMSIAELLQLIKTEPVSGEDGSERNGNESLDMSVDIEAISIPTKQRQNNDLWNLRSGQSGQFHKWTSDRKDQPVTCIDKNEVVESIIDVERRVNNVATRLEQVLRSSLDPRYRIEQVNSFDFSKITNKEEFGQEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L5</accession>
    <name>A0A084W3L5_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00012718</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC012718-PA"/>
        <property type="gene ID" value="ASIC012718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012718"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12000" checksum="864263B2B0C8E5EA" modified="2014-10-29" version="1">MQISRSYVTSELLPGIRQLGHHGKNVSLHGYHLAPVPVYPIVDGLTGVNLSLLAYGPFASLMKLGRPGGSAGTSEDTFDVQPAVRFPAVRGVGCWGSYFRFYFMTDVGRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4G3</accession>
    <name>A0A084W4G3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00013027</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4G3"/>
    <dbReference type="STRING" id="74873.A0A084W4G3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013027-RA">
        <property type="protein sequence ID" value="ASIC013027-PA"/>
        <property type="gene ID" value="ASIC013027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013027"/>
    <dbReference type="OMA" id="QKGFRYR"/>
    <dbReference type="OrthoDB" id="7764603at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="662" mass="73325" checksum="40F24F87CE30EB0C" modified="2014-10-29" version="1">MTAIYILIVRLEDWFAFREQCLGSDEYLRVALAHIYADVQAPVQPPPTTSHTGALNNGVSYTQQHRPQTNESSSRPSPAPPTSVSPTDGTPSSAPRSSSLAKRRRSIFEWSVDDGKGQATGQKVIVELLDDGVVPSTGESVSPPKRNDHQQSYEPILPSERPNGGETPGVGAVLPEDASGLLEQATWSKEYCARVNSLMVLVTGTRPYKCKICRKLFKARSNLRRHIKVNHADEVFEGESPPPECYDFGHIDRAGGAAFWKPPPQLPGAPDSFPSVQQQLLQQQHQQQQRPVQNVVHHSTPDGGPVKKKRRSANDPPITGPYHCQICPRSFKMPAHLAVHMKTHQRVEAPVVPSAIELQVQQQLLQRQSRTRTNIEPTDIIQLSDDDDDDNEEEQRKQQQQQDVSRQSDELDDGFDEEEGSLKEGASSDRSGEQQLQPDPASMANVELGPIKTQPIEKEEEDDDDDVVIQDVKPAPQPPPPPTEVQVKPKRIPAPGTIPPGPLSMKQRYRASMENGGALASRTQSPLETKPKPFQFIVARPKHSPVPSTSTPPPSPVASESQSSPPVTTTLHRCHFCQQTFSRDDLLREHQKTHQRDAPMPFRCRWCQKGFRYRQNYTLHVEKQTCRLLNGEAGGGASIKPPSSMMARPIAVANKPRGAAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4X6</accession>
    <name>A0A084W4X6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007989-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020405">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W4X6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013195-RA">
        <property type="protein sequence ID" value="ASIC013195-PA"/>
        <property type="gene ID" value="ASIC013195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013195"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022074"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="173"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1756" mass="199896" checksum="070B5DDC8B80196E" modified="2014-10-29" version="1">MYCDKVQDDSGRKSNAIVCSRFPAAFYNKAIAKAHFAKYGIIKDYYVLAPKRILVVIYDRPEAALRARNLGAWYQRKKLDIRLSQVPLDPVNVSKSRPSNVAVDLALDGKSICTDRKVLEARNEFITLAHQSCSKVQDRYRVLDARDRYINLCLEPRSSARNVSNIIGACEDMCPEKERYLRTMRGVVPPFERSDVVRATGQLDYKKAVKQFSLPHTGGALPSPYDLRTVPALGRSMRFLLENVVGRCDSENGANLLEWFNYMDDRLRAIRWEITQRELFSATTIKLMEQCTRFYIYCVVRMAADETLEFDQQKNTDSILDCLRDLKRMYSFEVQQRMPCVTEAEFRGFLLLMYLNSEEFNQELQQMSTELRETPVVQFAISVRCALSEKNFVRFFALLRATQYFNACILLRYVPTVREMALSAMRGTFLRDKPTCVELAKLTDALCFRTEDDAVKFFDHYRVSVIRPTGTVVFDPYAVSYQPDKPYCSRTDGWLVEREQRCSVVNLIRGSSVRDFGIQYRHLKFHSSFDSRGFFKKHLIAKILAITPVPSAAPAPAPESNDAHEEVIYISSDSEDNDTECVFGRETKEMDIDRHRPGLSVKVEVQTVETQPERISVREQMENTPEVPSAEFHDLTLADGIRKVPENYSANHASVKKEDGQTMASMEWGRPNETSVNGQKKVVVIDSLPAYSSHEDSDTVPDSSSLEDGRQFPNKVWQLRERCDSPAESIGDALRDHQSYSSEEAPEAREQQGDSACGVSESNCMDDNQESLPDQHVRKPGDQPYNPCSPTSTSCHDELDDEDALVNDEHFVEPEIYFKAQEIDRPYEITLEDRSDTSMECDEGYDQEEVVVVISDDGDSHQSCDFLLDAPLEVSEVNNNAVQEHIQKLDHLKKHRITEEDLEYQDQVVDRFQQEKQNSEEQGSSQCSADFVDRACCIGTKDLLEIAEENTNRNTDNRITDQTDQLQTQEILQNRNLQDDIELHNVPIQGRFSREEQDSGVNDHSQSTHCFQEFAIDQNPLDSTPEHHNFDPSKISVQNYRQDEAHPQNGTSGELPTEDLQEDIELIEDLDQYEGREEGEENAVLMELNANELESEELIEDDRVLQVNPPSSSEEEKVRKHLIRYISEKEQTEMLEKFLAQQIGEFAGIELATANQARRKQYRLARKYCDLWLANVRHAVRCRLLLRSVPLTGQESNNWSRGVKLCATVGKEEPIEPFGILKCAVRSEDADLREPYYWKLVISIPSDDGMQDEKRCCFNSFINRWLLEAAFKKDADDGEQPEHPFLYFATSRSSSPEAAICVRVVRDGVDSPEEAHKIYDRCNGLLFVMNVYEPIEQVRERFRRLLSMSSETRPAVAVLHYCPNHRQPGNVGEELKLDMTVARWKVFRWRNLTDNDPLRAACVFLAGYYRDQQRDFAQDPGRLEMSLLTAFLSNTVGSEWWSGLEGTCKKDANGGSYSLLGQNGNAVVQLYNVALDRVRYMVAREQLVSFARIPAEFDFLRARRPKSPDGLSTEALIPPDWSSAERFEQLKQLLTGMKLHPLPDLLLVAMERAASGAVLGGCQVDTSQLRVALECYLREYPVFSAGNTFRIKLLVHQLAKEVVSQFATDSSISAQHPTGTFVWIPLLAHVSEAVMRNTIMVTKTPAEVCYRRSELARFLKAPWAYEGLVSIPRPSSLAWRNISNVPRGLQLPSDVATTPEPSGKAHSLMPTDTVLGSRKRSSTGQSVFESKLPKMNSGQLEGNVSIWSNTDVSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4X8</accession>
    <name>A0A084W4X8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013198</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4X8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013198-RA">
        <property type="protein sequence ID" value="ASIC013198-PA"/>
        <property type="gene ID" value="ASIC013198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013198"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013198-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="11541" checksum="10C23F57C1C1CB54" modified="2014-10-29" version="1">MRTFSYQNFRQQDAHSYQHQRDAGCPFENPESNYQFLPQTLSQRLISPQDVHKKWYLLVRERVGYGKKQAQALIIHFSEKKLFGVVHSRGRAGVFEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W587</accession>
    <name>A0A084W587_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001416-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013221</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020525">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W587"/>
    <dbReference type="STRING" id="74873.A0A084W587"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013221-RA">
        <property type="protein sequence ID" value="ASIC013221-PA"/>
        <property type="gene ID" value="ASIC013221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013221"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002003"/>
    <dbReference type="OMA" id="PQCKQMT"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013221-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="24416" checksum="E26B6ACB9DCC2234" modified="2014-10-29" version="1">MNLDATLDSAEEARFLSKMGGLVKRLARSGGALARFSQRELELVLVLYYKLLKADPDGAGGLVSRQQLTTVLDTAFGITDTATVRRIHAALDGGTSAHVTPETWARLVALFVRGSLEERIRHCYAVYDTQRDGLIRRDQLMVLLRGCVRQEEGVEEAVKDLVDIVTTRLDLDRDGAISFEDFRQSVLQEPLLLECLGQALPDRRHVEAFAMTFLVSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5I9</accession>
    <name>A0A084W5I9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010241-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013415</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5I9"/>
    <dbReference type="STRING" id="74873.A0A084W5I9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013415-RA">
        <property type="protein sequence ID" value="ASIC013415-PA"/>
        <property type="gene ID" value="ASIC013415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013415"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008721"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF72">
        <property type="entry name" value="GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="375"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="427"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="557" mass="60026" checksum="29DB0F0E7D4E19B1" modified="2014-10-29" version="1">MVLGSIRAQSTSGTRAAVTSNAAECAEIGMSMLDQGGSAADAAIATLLCEGVSIPQSMGIGGGFVLTIYNKASGIVESLNSREVAPAAANKSMYIGNGDASFIGGLAIAVPGEIKGYWELHQKYGKLPWKTLFEPSIALCIKGSLVTDYLSKILAAQKSRILQYPDLAAIFINPSTGDTWKLGDRIKRPVLAETFKVIAMEGANALYSKEGSLLPKLMADLKNVGSILTENDFYNYRPEWLKPARTRLRNSYDVYSMPLPGSGSILSYMLSVLDGYKDLSVNDPLTWHRIIESFKHGYGLRTKVGDPRFVPTVNTVLQKMANKNYIAYIRDMIVGNMTFDNYDYYGADFAATNDAGTAHVSVLAGNGDAVAVTSTINYLFGSQIVSPSTGIILNDEMDDFSTPGLINAYGLSPSPANFIVPGKRPLSSMSPTIILDSRGNARMVVGGAGGSKITTSIALLVLRHLYFRQDICDAINAPRLHHQLAPMRVDYEKNFDPKVIAELVSRGHAVQQSKDDFGFAALTVIVNQGGSIKAAYDRRRAGSVSVRPHRAGLGNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5T0</accession>
    <name>A0A084W5T0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nuclear pore complex protein Nup107-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013561</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5T0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013561-RA">
        <property type="protein sequence ID" value="ASIC013561-PA"/>
        <property type="gene ID" value="ASIC013561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013561"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6673" checksum="96D47C9CABE5DE20" modified="2014-10-29" version="1">MIPTSSEMILLDGVDKEAAHIWPRMATLGVLFGVLRSRWCFSPTPPLPPHLLFELCHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6F2</accession>
    <name>A0A084W6F2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013773</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6F2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013773-RA">
        <property type="protein sequence ID" value="ASIC013773-PA"/>
        <property type="gene ID" value="ASIC013773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013773"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="23508" checksum="5159470644B37A25" modified="2014-10-29" version="1">MIINCPRQLRTQLLQYSRTATKNQEDVVVEVIVINYTFSSSPTPAVILIRWRSSRLDLKPVTRSRPNRRWRFLRRHSKSMDDAHCPIPASYAEALLSSPRMCSMFAKRLALKRNNDREEERAVTIPSLQSPFPLGVRFETRPTQKTDSESRKSEALGQRNLEHRDDSLDAEDLPEPVLVDRALLLHVSGQFFSNRLLQRARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6L2</accession>
    <name>A0A084W6L2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002625-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525308">
        <property type="protein sequence ID" value="KFB45856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6L2"/>
    <dbReference type="STRING" id="74873.A0A084W6L2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013813-RA">
        <property type="protein sequence ID" value="ASIC013813-PA"/>
        <property type="gene ID" value="ASIC013813"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013813"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012770"/>
    <dbReference type="OMA" id="HQYIPAS"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="146"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013813-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="37635" checksum="3FDBDC4EA7CFE2C2" modified="2014-10-29" version="1">MQATVVAGPKYIPTSSFYINKRIGEALELDGAAPQHRPHRVAPPVGKVIASTGAGGNLFGDAGQGHAGATFTPMRQTFGGASPTELLASPREVSETDLYLLGAIEKLVYRVDYMENRLRRAEQIIYFLMAGNSQKQEPCPQNFTQVHDRCYHFDIERGLNWKSASTMCKSYGAHLAEFETIAEFQDVVAYILNNPVNRGKDFWLGGLNPGLLWIWANSAKPVNPNTNLSSITGTTKKSQPLTTPATPVDTTNGGGDDGDGAAKKQGTKIVNNASKHPTLEITGNGRCLRLSYNSALYTYGYRGEDCSAQFNYVCELKDKTLDNEISRIAKELKLNDIPSVNPSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7E0</accession>
    <name>A0A084W7E0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7E0"/>
    <dbReference type="STRING" id="74873.A0A084W7E0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014190-RA">
        <property type="protein sequence ID" value="ASIC014190-PA"/>
        <property type="gene ID" value="ASIC014190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014190"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004842"/>
    <dbReference type="OMA" id="APACTTH"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF72">
        <property type="entry name" value="GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784640" description="Gamma-glutamyltransferase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="405"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="457"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61646" checksum="55B798552FD0B4A3" modified="2014-10-29" version="1">MKRRTIFSLVITVIVVVILLAVATLAWAGNIPSEGSTAATQRSGAVVANGAECAEIGARILRLNGSAADAAIATLFCEGVTCPQSMGLGGGFLLTIYDHQNRTVETLNARETAPAASERSMLSAAKARGDDTRGLTVAVPGELKGYWELHQRYGKLEWATLVQPTVELCERGHLVTPYLSRILQRVEQQLYAEPSMREVFINPATNRTWQEGDTIKRMRLAESLRIVAKEGVDTLYSRNGTLLRMLMKDLKAFGSIIKEEDFLNYRPRWEAPDTVELKSGVEVHSITIPGSGTIQNFMLRVLDGYEDMAPKDPLTWHRIVESMKFAYGLRTRIGDPVYTPEARGVIQNLTDPQFASYVREQLIDDEQTHNDFAYYGAKFADVEDKGTAHVCVLAPNGDAVSATSTINYLLGAKIRSQSTGIILNDEMDDFSTPGTVNTYGLPASPANFITPQKIPLSSMTPTIVTDANGTVRMVLGGAGGSRITSATAVMIFRHFVFGDDLNAIMSEKRLHHQLAPMWLDYEAGFDQSILDGLTKKGHQVKEKDLMLDLRRPPESCRMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7J3</accession>
    <name>A0A084W7J3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007776-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021258">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7J3"/>
    <dbReference type="STRING" id="74873.A0A084W7J3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014189-RA">
        <property type="protein sequence ID" value="ASIC014189-PA"/>
        <property type="gene ID" value="ASIC014189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014189"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002224"/>
    <dbReference type="OMA" id="DLHHECS"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DHD_Ski_Sno"/>
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        <property type="entry name" value="SKI-like oncogene a"/>
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        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
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        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
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    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
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    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="c-SKI_SMAD_bind"/>
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        <property type="entry name" value="Putative DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="224"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="39280" checksum="16F12C5E8991F6C8" modified="2014-10-29" version="1">MSETYVPPHVISVLKTYQDTAPKSLHGPGLSLVHPSKAGSIVVRADTPEHHVPAHLHLHHSTGGHYGGGRGGGGGGAGSGTAVDEEQPQRLTTTIVPPVPIMTTPDPDCGIVQMTILEGKRIGCFLLGGEMRLCLPQIFNNILKMFSLEQINASIQELMIYLYNCTDQQLQEFKRARIIPETAQTCGLITRTNAERLCSALLHKQFEHRTRTALKMGGSGGHSAFRVYHRCFGKCEGIFTPELYGAGEEPACIECCKCNGMFTPQEFVCHQHEPQEIRTCHWGFNSSNWALYIHVDEGEKNREEYAKLLENIWAKERDMEPDQECDQELYYARQKVGKSDIWNSGPAYEGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8G3</accession>
    <name>A0A084W8G3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014498</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021427">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8G3"/>
    <dbReference type="STRING" id="74873.A0A084W8G3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014498-RA">
        <property type="protein sequence ID" value="ASIC014498-PA"/>
        <property type="gene ID" value="ASIC014498"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014498"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007555"/>
    <dbReference type="OMA" id="YHSEETK"/>
    <dbReference type="OrthoDB" id="6371642at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784693" evidence="2">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014498-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="436" mass="51867" checksum="45C10065876B121E" modified="2014-10-29" version="1">MRLTVVAIALGLVALTSAAYYPSSHPVKGVKYADKDFLFKQKFFFEVLRNIHLPLQFEEYLPYTKSYITDESKYVNFEEVAEFFNFYKVGFLGKGELFSIYNKEYMTQTYLLFNFFYNAVDFDTFYKNVVWARENVNEGIFISALTLTVFQHPELKGFVLPAIYEIYPYYFFNTNVIHSVTFRKQYDQKFGFASNGKYNVVYDNYTATYPIDYYGEEKLAYFTEDIGLNAYYYNFMMDYPYFLGTDKWNFSKDRRGELYLYMYQQLIARYYLERQVNFLGPIEEFDYDFPLKTGYWSKLSYYNGIRSSVRDRTTYTELYKKIMTAYNGGEKFVLDNSEAHCGFPDRLLLPKGLPSGYEMTFYFIVTPYYAPKVPQFSTYDNTYQCGVGSGSKYIDDLPFGYPFDRDIDFSYFYTKNMYFKDVLIYHSEETKVNSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8S7</accession>
    <name>A0A084W8S7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014668</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8S7"/>
    <dbReference type="STRING" id="74873.A0A084W8S7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014668-RA">
        <property type="protein sequence ID" value="ASIC014668-PA"/>
        <property type="gene ID" value="ASIC014668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014668"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014473"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="25894" checksum="33F8CE56696525D6" modified="2014-10-29" version="1">MQYLQNPNVDDELGFDPFLETQKGSKILPFMNGGMPLANGQPQPPQQQQQAPQNGNWNPQMQQPFMRFQQNEPNHLAQAQPQNGLNKPAYGNNFPDWTSLDPAIVSYRQFSFMNGPNQPAAGDMFLNAQQQQQQQMNQQQNLQPGQGFGHHGLNLQSNLMGQQQQQQQQQANPQLNFSHANWLNNEQSVYMNGLTNGGFPNGFDKFSIPMPPGFQNNVPGNNKQKAECIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W911</accession>
    <name>A0A084W911_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014702</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W911"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014702-RA">
        <property type="protein sequence ID" value="ASIC014702-PA"/>
        <property type="gene ID" value="ASIC014702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014702"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10532" checksum="6AF315F80E07CCF4" modified="2014-10-29" version="1">MAPREQHFRLCIEPVAMPNLCQLGPVAKIVPRSPRVSRDMSPRRGTDEAVCGCDPTRTSRPMPNPRTQLCVCLWAVPRFRCVPSSESASNLGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H3</accession>
    <name>A0A084W9H3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014893</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525323">
        <property type="protein sequence ID" value="KFB46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9H3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014893-RA">
        <property type="protein sequence ID" value="ASIC014893-PA"/>
        <property type="gene ID" value="ASIC014893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014893"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19029" checksum="D6CEE9922E5ACB0D" modified="2014-10-29" version="1">MKRSDGGNQMYRPESAKLRPSSDGAQLCHTEEPDPRPGKEAEPIINFSSSSKITTFMQHLPHHRKMANDPAAILLKRSIRTQFATLPFPSGRRRDDAGVPSSSVSSYRLTFPLWRTLFEPVAIAGVAIWEFSNFPSTVEQTSSKRSITVQAGSHSGASRRCGHPPSPRQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAG8</accession>
    <name>A0A084WAG8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ribokinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015236</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022183">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015236-RA">
        <property type="protein sequence ID" value="ASIC015236-PA"/>
        <property type="gene ID" value="ASIC015236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015236"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12961" checksum="EA7AD9549ED936FD" modified="2014-10-29" version="1">MRNGNPREHISTCISFDSYHKTTPNGAQNKAQGLRRRKSQLPNPGQLRETNVEAQNLICAKLVGKIRYGNRLFDCVLIFPPPPRKTPKPNAIRKLQLSPIVSVGRRNSGQDMDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAW5</accession>
    <name>A0A084WAW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015601-RA">
        <property type="protein sequence ID" value="ASIC015601-PA"/>
        <property type="gene ID" value="ASIC015601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015601"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="255" mass="27796" checksum="53AABB56575591D4" modified="2014-10-29" version="1">MATTRADLQRGDTAETEHRSSPPGELSADLYAPEKIKGGKEKKKVKYRPRGVKVRARIREGRPPVWRREGRPFGFARVNSVGPGFLASIVGGKDEATDQHLHRLPVGRFPRRVSSASEVLRSPRAPAKYGTPTKSASGRAAESVPGLISHFRATVSTTLRGNHAPIGFAVKCRRRQATVTSIVSPPTTTTTMTIPKSRADSNYVFKRAILPRAAGIGSPWVCSATKQTVVRSVCFARELLIIELFAQCGQNVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBB0</accession>
    <name>A0A084WBB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011482-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015458</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBB0"/>
    <dbReference type="STRING" id="74873.A0A084WBB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015458-RA">
        <property type="protein sequence ID" value="ASIC015458-PA"/>
        <property type="gene ID" value="ASIC015458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015458"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053265">
        <property type="entry name" value="Serpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131:SF0">
        <property type="entry name" value="GEO10195P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21131">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784627" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015458-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10629" checksum="AE5D045367DDE715" modified="2014-10-29" version="1">MRFMSTQLLLALVLLSMLAWNVKAKPDQANPDQATRPPPCPCPRIYLPVCGSDLKTYGNECVLNCRINSSYGERINLTLLREGECVEGDTVEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDP7</accession>
    <name>A0A084WDP7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP005032-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00016478</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023051">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDP7"/>
    <dbReference type="STRING" id="74873.A0A084WDP7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016478-RA">
        <property type="protein sequence ID" value="ASIC016478-PA"/>
        <property type="gene ID" value="ASIC016478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016478"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008663"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005106016" evidence="10">
        <location>
            <begin position="34"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB48341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="614" mass="69164" checksum="C971E4DD5CA68BA6" modified="2014-10-29" version="1">MMKLHRPRWSVALPFRAVLLCAVLVLNWSTVYGDEEVPADVENTLSEDAELYVTPEVDPSRVYFAEHFDDLFDDVEKRWTKSKAIKDDAAEEVAKYDGEWSVEQPQRPILSNDFGLVLKSKAKHAAISSRLNRPFVFNEKPLVVQYEVNLQEGQECGGSYIKLLSAGDGTKDLKNFHDKTPYTIMFGPDKCGNDVKLHFIFRHVNPVNGTITEKHCNKQKDRLDDPFKDKRPHLYQLIVRPDNTYTINVDHKTINEGSLLTSFTPPVNPPAEIDDPEDRKPQNWDDREKIPVPDATKPDDWNEDEPAQIADPKASKPAGWLDDVEEMVPDSNAVKPDDWDNDMDGEWEPPLIPNPLCEKAVGCGLWKPPMIANPSYKGKWRPPLIANVNYQGKWAPRKIPNPDFFEDLTPFRMTSIAAVGIEIWSMSNDILFDNILISDDVAVADEWAAQTFDLKVRTLDRQAETVVSRVLKYCNNNPWMWAVLVVVVGLPVALLIYFLCFAKADAKAEVGRRKKMEDSQIPTGEQEAEELQQDTDMSPLLRSTGGADGSASAEVDDDQDDEDDEAEEEDDDEEAEVAPELAAREEEASASDAPVDSKVVEGGEGVKKRRARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEB3</accession>
    <name>A0A084WEB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005862-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016869</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016869-RA">
        <property type="protein sequence ID" value="ASIC016869-PA"/>
        <property type="gene ID" value="ASIC016869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016869"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013727"/>
    <dbReference type="OMA" id="RIIHYFY"/>
    <dbReference type="OrthoDB" id="7761609at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="297" mass="33521" checksum="8AB6FF2007E2DD3F" modified="2014-10-29" version="1">MAEEEHIEAPQAVAHRIIHYFYESKAIGRDAWNLSFWEEFSLKNRDIGMDAKALRAFFFTDIMHCADHLDGVPYEVLQCINPLFNRIRADVLEDHDIVEGTDYVFDREGIPSTSAPTGAISLLPVQLKTTESGSIPSKTKQCDKTPTVEQILRHVSDGLSELLWTKEEKSSRPKLTTAVCLQRTRLLQQNHIPLVKFVEPGMSCYERYRQMGLVDPLENESNHSGEYQQRFQTPQGMSTPLGTQVGGDASGSTKGSAVGHSSRDEMQASCNYRLPNIAPNYNAVLKYVRSKPRKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEL5</accession>
    <name>A0A084WEL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016654</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016654-RA">
        <property type="protein sequence ID" value="ASIC016654-PA"/>
        <property type="gene ID" value="ASIC016654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016654"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000129"/>
    <dbReference type="OrthoDB" id="7744869at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016654-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="216" mass="24074" checksum="88CDEBF83ABB1B5E" modified="2014-10-29" version="1">MASRKISTVSDSVTIVGGGGIVGINHRYRAEGGICSNEPNQNNNYHRRQEPHFPQIKIVIDEPELNDPEAPALGAMALQPLRRQATVHRGSKPSTGMGKKSPNASSFLTIFDSTGGQAGARRRTNGGKVASYDEHYYSPVEGLHLYRGDYVDDDEEDYGIDTDGYRQTRLHRGRGTRDHQDEEEDDEEEHDNDDDGEEHEDVDDEEDDEENGGDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF84</accession>
    <name>A0A084WF84_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017140</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01023318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF84"/>
    <dbReference type="STRING" id="74873.A0A084WF84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017140-RA">
        <property type="protein sequence ID" value="ASIC017140-PA"/>
        <property type="gene ID" value="ASIC017140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017140"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005172"/>
    <dbReference type="OMA" id="DHPIHPV"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF7">
        <property type="entry name" value="GST-CONTAINING FLYWCH ZINC-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="208" mass="23510" checksum="A9633DC64C072952" modified="2014-10-29" version="1">MKLYAVSDGPPSLSVRMALEALNISYELVNVDYGKAEHLTEDYAKYLCDKYAPDSELYPKEPKQRALVNHRLCFNLSFFYPQISAYVMAPIFFDYQRTDIGLKKLTLALEAFETYLKKSGSTYVAGDSLTIADFPLVASVMCLEAIEFDVSGKYPTVFKWYSGFKTAYPKLWAIAAKGMEEIAEFEKNPPDLTGMVHPIHPIRKVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFP6</accession>
    <name>A0A084WFP6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017051</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017051-RA">
        <property type="protein sequence ID" value="ASIC017051-PA"/>
        <property type="gene ID" value="ASIC017051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017051"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759994" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="14194" checksum="CCA8CBB1B189135B" modified="2014-10-29" version="1">MFTETIWFALRCIFLFWMLFAPKKTVSSSLKVTRVVGAECRVRVAGEGRTDAAAAVCDRSSSIKFYLKPSYRHPPPFRMQQQQQQMQLRSHLTAFFYHEKDGGVRADERHRRWSGHVGDASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG78</accession>
    <name>A0A084WG78_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="5">2.1.2.2</ecNumber>
            <ecNumber evidence="6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00017226</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="5"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC017226-PA"/>
        <property type="gene ID" value="ASIC017226"/>
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    <dbReference type="OrthoDB" id="2018833at2759"/>
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        <property type="reaction ID" value="UER00126"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
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    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
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        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_C_dom"/>
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    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="21">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="20">
        <location>
            <begin position="340"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="21">
        <location>
            <begin position="469"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="19">
        <location>
            <begin position="659"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB49222.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="860" mass="91635" checksum="1FDFC17CC52D69B9" modified="2014-10-29" version="1">MCANDVLCAGAEPLAFLDYIACGRLEVPTAALIVKGIAEGCRETNCALLGGETAEMPSMYAPGKYDLAGYCVGVVEADQILPRVDRIRAGDLVIGLPSSGVHSNGFSLVNKILERTGTKLTDRAPFGEDGCSSFGEELLTPTRLYVAPVLPLLRQTDTVRALAHITGGGLVENVPRVLPAELAVEVDFSEVVIPPIFGWLAAAGNVTEREMLRTFNCGIGMVLIVDGTDGTWKERLAGEGAVLLGKVTARKGDAEQQVVVRNFSVAIERSAAPYRSKFPVKPSSNGPAKQPSSISYKDSGVDITAGDDLVQRIKPFAKSTNRPGVMGGLGGFGGLYRLRDAGLKELNDPILVLGTDGVGTKLKIAQDSHRHTTVGIDLVAMCVNDIICNGADPVNFLDYYACGKLDVPVAAQVIEGIAEGCRQGGSALLGGETAEMPGMYAPGVYDLAGFSLGIVEQSRMLPKVDTVCPGDVIIGLPSSGVHSNGFSLVHKILEFNGLTLNDVAPFSATGKTFAEELLVPTKIYVRELQPLLAEDGLVKALAHITGGGFTENIPRVLPADVAAFLDLAEMHVLPIFGWLARAGNVTADEMLRTFNCGIGMMLVVATEHRDTVLERLEPFGGRMLGTIVKRTDPLGGRVIVNGFEETLQQAKATCTLPKKRIAVLISGSGSNLQALIDATRNTAFGIRGEIVLVVSNKDGVFGLERAAKAGIPSKVILHKNYATRELFDEAVSKALTDARIDLVCLAGFMRILSESFVKRWKGALINIHPALLPKHKGTHAQRQALAAGDLESGCTVHFVDEGVDTGAIILQHRVPILRNDTEEALTERIHRAEHRAYPEAVRLVANQIVTLGGEGQVVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGZ1</accession>
    <name>A0A084WGZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017686</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017686-RA">
        <property type="protein sequence ID" value="ASIC017686-PA"/>
        <property type="gene ID" value="ASIC017686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017686"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7605" checksum="31EA6E6BDBE5DE54" modified="2014-10-29" version="1">MFSIWSRPPRFSPSVINPLIALYPALIVQICSEPRFVACRQKSFVFATPFATVGGMQFRVCQTKGPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHT0</accession>
    <name>A0A084WHT0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00017789</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHT0"/>
    <dbReference type="SMR" id="A0A084WHT0"/>
    <dbReference type="STRING" id="74873.A0A084WHT0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017789-RA">
        <property type="protein sequence ID" value="ASIC017789-PA"/>
        <property type="gene ID" value="ASIC017789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017789"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007275"/>
    <dbReference type="OMA" id="IPRIEGC"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
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        <property type="entry name" value="GD10853"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Spondin-1"/>
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    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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        <property type="entry name" value="Kunitz_BPTI"/>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
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        <property type="entry name" value="Reeler_dom"/>
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        <property type="entry name" value="Reeler_sf"/>
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    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
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    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
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    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
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    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760005" description="Spondin-1" evidence="13">
        <location>
            <begin position="41"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="16">
        <location>
            <begin position="199"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="685"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB49774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="900" mass="101422" checksum="230645A105B752FC" modified="2014-10-29" version="1">MRSIRRRAPGREHRATPGRLLLVGALVLLQLLDATQLARAVRCDRSPEGSGANKSPADGRFRLRISGNADKYVPGGSYTISLVGIRSMQVPHKFSGFLLAAEKAADALPTGFNNVGTFELLGDPLTRFSERCPNAVTQTNSLPKSEIHVEWVAPPSGSGCISIRATVVEHRDVWYMDDGPLSKTLCEDEADSVDTQPPVLKECCACDEAKYELTFEGLWSRHTHPKDFPSNGWLTRFSDVIGASHTVDYRFWEYGQVASEGLKQVAEHGSTRMLESELKNQSDKIRTIIKARGISYPNVTGKTFAVFRVDSNHHLVSLVSMIDPSPDWIVGVSGLELCLTNCSWIENKILNLYPWDAGTDSGPTYISPDQPTNPPDAIRRIKSNYPNDPRSPFYDPAGAEMKPLARIYLSRQRLYEKNCEAENEEENETKQACETEPWAEWTECSSRCGKGKQTRRRVYKHPMKAKQAECKKKLFDRRPCVGTDRDCDVNSQEVEEAFQGDPECEVTEWGPWSECSSPCGKGNKTRSRKYKKKGARKKCERLPNPPRLQQTVSCDADCAGDISQPVLSSDINPRCKMTQWSEWSPCSVTCGLGRKMRTRMPINKNMKVHHKRFVNYYHTRMRTSPHEDEEDDSGEDEDEEQDGMDNDLHITDQNDPCYGVETVEEVTCGHDLPPCDGLYGVPELCFLEPKPGNCRDSQSRWYFDSDKNDCSILFFTGCGGNNNNFMSREDCLDTCSKDRKFTNIPIRDQISTNSAAGYGGSEYGSSDLKQDCKTSHWKRGPCNATCGEGFRVKSRTILVHPSGGGQRCPRKLRKVERCFVHCDSSRHDTYPSWGPSDRYEPEPIECEYSAWSAWSPCSRTCGDFAVQQRTRYVLNPESARFCPHRLEERKCDIMPCLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI89</accession>
    <name>A0A084WI89_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00017966</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 11"/>
    <dbReference type="EMBL" id="ATLV01023923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI89"/>
    <dbReference type="STRING" id="74873.A0A084WI89"/>
    <dbReference type="MEROPS" id="C12.008"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017966-RA">
        <property type="protein sequence ID" value="ASIC017966-PA"/>
        <property type="gene ID" value="ASIC017966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017966"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024416"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB49933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="228" mass="26014" checksum="7666D3CCF3D6575D" modified="2014-10-29" version="1">MDCWLPLESNPDVLSKYMTELGVSPLWSIVDIYGMDDELLEMVPKPLKSLIFLFPCSKAHEERRAKEDEELKSKNIVHPEKLFFTRQYIHNACGTIALIHAILNNPDIEVQDGSVLKKYYDDAKNLTPEERGELLNKSKEFMEKHESNAQEGQTATPDINDAVYHHFVAFVHVDGKLYELDGRKNFPVEHGNTSPDTLLKDAVQVCKKFIEVDPTEVRFTLLGLAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIN1</accession>
    <name>A0A084WIN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011897-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018125</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC018125-RA">
        <property type="protein sequence ID" value="ASIC018125-PA"/>
        <property type="gene ID" value="ASIC018125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018125"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007477"/>
    <dbReference type="OMA" id="VRFENPI"/>
    <dbReference type="OrthoDB" id="188713at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261:SF4">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1992" mass="225502" checksum="36BCC44B66958B7E" modified="2014-10-29" version="1">MFYFQRAISTSKVSVSEATFLLIFPSISVYFGWEKLFLPPLFTTVRQVKGKFEKYLEHQAVTARHFDCVSIAHLGFVAVANYHDHELNVFDAGSPVFQIQEDGTTEVVQTFGQPNQHTVHLWVHGKNVYLTHTYTNLDASRPNVCPLYRWSGYFFDVVDHMPCYNAVQIEPFSIEQQMFVAVARQMAAGGMRKDSFSDIFVLNPDTQKLTLHQQIYTYSVSDIAYFFIEDRERREHFLMAGNSLTAGTGASNNEEGRKTSRDADQNSIVYKFVDGFFVPFQNVELNGVKMFLPVVHENGEFLLLVLCHDQPLLIYEYDGWKLVPSRIDYTGEAFAAGVAHMRVYRHIVNASVIVIANSNLFGKSVNLFTPQYGVENDLRQVYAHFIEWCERMHEQTAQVNLEELYNRLAELPDNAPDGARSIDKNIELQDSFVSKAKAGSIKTKNILIDDAHLSYVAEVNEYVQRVNDKMDLVEKTIHESVLTNGTVHWHGDLEVSELIAPAGQMKQLDVKVLNNGAHKTRQADDSTARVENDTTEVDRLIVDRFVNVRFWNGHAAESLLLIDDPPAKWKDVSVSAEKVVVGGNLYVNKLIDGIFFHPSNVLLPGVDQVLSGHNLVVKDLNVNRLTSKRLNSTDAAAVHRMMDQSRTLLAKSRGAMPQAYGNDFDTIDVDELKLTGLLNDMDPRYLTDNVLLHEAENQELVAKLVVDQITADNIVISDSKLSGIEWENVARINGAQQILQDLQFVQPITVDSLVLRDRLNHIPVIDGKLQVLLLDSNETQSITGTKTFDYVTLLKPIELQGKIDGDALSKMNPIVTTVEDLVLDGNYTILGNVTFNGPLWAHNIMSASGSHDFHRLATHGLRLDGTPASDQVIRFLQPVFVEHLGANKINELDVADLVPQAAGTVQYITGRKTFIGDLIVDGVADANEINKVDLNQLNRTIFRRGAEGVEQTIEGTIHFDTIITSVTNAKNILFEGKRMDRLLRFDIPQNVSAPVRFENCTIYVENAVVAQELQTDNSSLVFGYDMDYLYQDTLRPETDVATEAPVVVGHKSFRNLTVGQLVLLDGSTINSIAVENIKHILDDREKRTVIKQELYSFQGDITVNHLYFNGSINGIPKHLFCRAWLMRTGDQTFTVEQTFDTVMVEHLNVTGKLNGDTTMDQLLENVYRTDREEYINQAIFHEGIVSYEPCSVGGLVSGLDLSNDVLLKQSPEIQTLGTVQVSQTLEARGELHILNNLNGIHFPKLMEFFSPADDKERAERLPPNVEVRGNVYFEHDPTLIHLNGHNIQKLYDEVWLPHRPTVLTGRYHFESVEFQNSLHTNPVNHLDWNVVEARCLSGKRPQNISAPLLFEGDVTVYAGAVFDTLGLKGMLKSMKNSPGLDVHEYDRNVLRYNENQEITGKWTFHNLQILGDLHINMLNGHNVQTDYMRTDVSANNFTVTKRFRELHVESIVCPPPCVIQEVDMDEWYKNGLRLKGNQTLEGTLRIVDGVITGNVEVLGTVNGVRYDVDHLLLKSVPQSVNGTMSLITKFPKENKIFPLVFESLHAQTINRKDVAKFLTNAARNDKNPLTIRNSVTFVNPLEVEETLLEGDMLFGTNITHLILSTSYHTGVNELEAQVRSLNSVNEKLSENVFESSPVFSHFEKLKSLPIHAVRMLVFTLPLFPKPVEVVAVHMADSSRPSAINFYLWNSKESRLMPAKNIPSIVGRERVIVNMKRLNLGKNQHMFLQFFKQESNYFIQQILDLHVDPTGVNKFAPLYVMNSTRARDVIWMKLGKLDCIIMYSKGMIGFEVRCLREQNLIPILDVRQLEETVAPIQIVALENHFVMLDNNDRIQIWRPTVNFYLKHHQTIAVSRPSYISVARYENQLMLAINSEHTPNTAHHGSIEVWRKSLTTLNSTFTQHQLILTKVPKQLQFSVLPSNELLLYTLTENWLHPLVVYRYEGVTGFREVLTSNTIRQKAKRLSVLKFRQARKEIVAIVGPESTDFVNVVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIV1</accession>
    <name>A0A084WIV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP012387-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018205</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WIV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018205-RA">
        <property type="protein sequence ID" value="ASIC018205-PA"/>
        <property type="gene ID" value="ASIC018205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018205"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005431"/>
    <dbReference type="OMA" id="WSCECSY"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000418">
        <property type="entry name" value="protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784932" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1417"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018205-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1471" mass="166418" checksum="4B4085F4D1437086" modified="2014-10-29" version="1">MNRCDLILPVLLLLVSVQVNYSLQYDSTESRYFHTTGADADSGGVSNLRYDAPDDCKYRVLPGNQVDLSCNLRTVNSEFDNTNFSVIPAEHTTALTILCNEAIMARSKLQPNSFMHLVRLKALKLEFCKIAKLSNDVLAGLSDLRNLTLRTHNIVWPDVNLEIEPDIFGHTRNIEQLDLSTNNIWSLPGNLFCMLSGLQWLNVSSNRLQDVNDLGFREKIDAVEDSLNQQEADKKNTNLTGTSDKPSVSCSLDIEVLDASWNHFVLLPSAGFGMLRRLKQLKLHNNEISMVGDKALRGLKELQVLDLSTNNLVALPTDLFLDPAPSIQEIYLQNNSISVLSPGLFSKLEQLQALDLSQNQLTSAWVNRETFTGLIRLVLLNLASNKITKLESEIFSDLYTLQILNLRHNQLEIIAADTFSPMNNLHTLLLSHNKLKYLDAYSLNGLYALSLLSLDNNALTGVHPEAFRNCSSLQDLNLNGNELSQVPLALKDMRLLRTVDLGENSISVIEEPGFRGMNNLYGLRLISNNIENITRKAFRDLPSLQILNLARNKIAYIEKGAFELAVSVQAIRLDGNMLTNIDELFTNMPNLVWLNISDNRLEHFDYSYIPAHLQWLDLHRNELMELTNRYGLDHQVHLQTLDASFNRLTRVTPATVPNSVEFLFLNDNLIVHVDPHSFMHKTNLTRVDLYANQLTSLDIKALRLQPVPESKQLPEFYIGGNPFVCDCNIDWLQKINHVTSRQYPTINDIETVYCKLMYNRERSYIPLIEAEPKHFLCSYNTHCFALCHCCEFDACDCEMTCPNNCACYHDNSWSTNIVECSAAGYTDIPNNIPMDTTEVYIDGNNLVELSGHSFIGRKNLRVLYANHSNIEAIYNTTFIGLRRLTILHLENNNIRKLYGHEFSALESLRELYLQGNRIAYIEDHTFAELRKLEVLRIDGNRITSFEVWQLNANPYLVEIALANNLWTCDCGFISKLRTYLQSNVDKIADAKEISCSYNNATSILRENGTKCTFREGMSSIVHQQEIEDMLPLLLVATCAFVGFFGLIFGAFCYRKELKVWLHSGLCYRSGTFVNDYDKDRLYDAYITYSLHDEQFVSQILSSTLENDIGFRLCLHYRDLISNAYLADTIVEAVESSKRAILVLSKSFLYNEWTRFEFKGAIHEVLKRHRKLIIILYGDLPQRDLDADLRLYLRTNTCIEWEDKKFWQKLRIALPHVKKNSGISKPSAINIYASATNDYNTAGRPAPLRPPVMSSGRLDGALPHPSYATIGPNCPRNCDNYDTVSNCKYNTTQLHERHLSADVFGTIRKTVPEGRQHEYAVPSNCLLDTTHETYNTTTSCERIAGETYECTSSTSSKYSMSSRGSAGSESGSHSISSTRQHDFPNGFPPNQLPATSFTYSGSNSHHALPPHHRHHHQQNGSSRSNSSKPSVSSGADSGTVGPVVKTTDKGSTDRTIEVNNFNDRRLPQAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ03</accession>
    <name>A0A084WJ03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP012066-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018263</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023960">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ03"/>
    <dbReference type="STRING" id="74873.A0A084WJ03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018263-RA">
        <property type="protein sequence ID" value="ASIC018263-PA"/>
        <property type="gene ID" value="ASIC018263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018263"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022466"/>
    <dbReference type="OMA" id="RMKGLFD"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000022">
        <property type="entry name" value="AGAP012066-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="63"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="769" mass="87995" checksum="CD76D52B04986E67" modified="2014-10-29" version="1">MAPKDPFKNSDESKQKRQVFGRPSSVSRFMPVTFKNDEAIYDPSNQSQNFYHRRQECLAQKTLFKDPDFPATESSLAMPNVTNVRWRRPHDITPKAQFFVDGASRFDICQGALNDCWLLTAAANLTAHPWLFKRVIPEDNGFEGDQYAGIFHFRFWQFGHWVEVVIDDRLPTDAEGKLIFGRSANRNEFWSALLEKAYAKFYGSYGALDGGTAREAMQDLTGGLTEFFHPKMMIGKEDQLWDILCSGFEMGSLFACNLKSDPSGETSPTGEGLLRGHAYSISKVHTIEGLHSDGTSSVRLLRVRNPWGVGGEWNGRWSDKSREWKAIDTRERKRIGLTIENDGEFWIELNDFIKYFDRLEVCHLSPELHSIEDGGSDELPSQSAFRWQVSSLDGQWIRDTTAGGNVSFLETFSLNPQYTINVQQSTSSSSVVIALSQKFRRVDALPSLTIGFVVYRVTRENLRQKPVPTEFFKNSDHAIVGGSIYINAREVSCRLNLDPGLYLVIPSTFEPREEGEFLLRIFTTQGNTLHENDAILCFGTIDDRVPERNQLFESPRWPLLADAFYNLTDSNQRIDQPRLQEILGKHFFYRTACGSSNKKDLSATHTKRAAASPWRKIFSCLQQICSCFWLHSLHRRREAQSIGNLLEQNDNSRQVELEQIAKLLMSRTGDENVLGYDQFRTIVRDVYQWESVFRLYDTDGSGALDRKELRNALRSSGFNINNRILCKVLRQVEKLDRPQIELIDFVLCAAECRHAIGKFVSKLCYFYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ86</accession>
    <name>A0A084WJ86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP011818-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018360</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ86"/>
    <dbReference type="STRING" id="74873.A0A084WJ86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018360-RA">
        <property type="protein sequence ID" value="ASIC018360-PA"/>
        <property type="gene ID" value="ASIC018360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018360"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003768"/>
    <dbReference type="OMA" id="KFATGPP"/>
    <dbReference type="OrthoDB" id="10055027at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="381" mass="43915" checksum="70EC1851E21AD826" modified="2014-10-29" version="1">MIDVIYFFVFVVLCFFTIFPTTEIESVGLTVDQWCSRYVTDGFVQYHIKLTSFKLLLHTSMPLCYFLVLWLLAWINPAEFGTVIQFTVRGQYLWNISITLAIALFIVTIVNVLYWAMDAWNNHPIAKKLQRFTTPMMPDWRSVATNINDEYRRDTKMVIRSNAISTLVVTESWIIKTNLYGISVARQNESSLVAYKVDFQDVLTDTVDATQFINIAVKPLQELLHFTIRVNGEHFKDFQDHVNRPIVLLPSVKFRSVIDRFVDVFKEQVALNPIVPSLAVASIEGDNCLACLQVTPDVRIQKQCLDVGEDGLLLPDEQRCQPCHCRPLWCVSCLAIWFASRQQKSERDMWLSKKATCPMCRARFCVLDVCMIEEIAGRIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ89</accession>
    <name>A0A084WJ89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ89"/>
    <dbReference type="STRING" id="74873.A0A084WJ89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018363-RA">
        <property type="protein sequence ID" value="ASIC018363-PA"/>
        <property type="gene ID" value="ASIC018363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018363"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011464"/>
    <dbReference type="OMA" id="HAANQHH"/>
    <dbReference type="OrthoDB" id="7962864at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018363-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="13220" checksum="B80A8E6E894E5A5B" modified="2014-10-29" version="1">MSDKLTGGRYNRISPSSGRGSIIAYSPLPKSEQDCLQAPGNNCLAIPLSAIQTTADHNSVHHGPHPANHLGHANSLPAPGPGGMVGGKLPNATHGMLAHGDGQKHAANQHHGNGNNGNNNGNHNSSVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKY3</accession>
    <name>A0A084WKY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005045-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKY3"/>
    <dbReference type="STRING" id="74873.A0A084WKY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019222-RA">
        <property type="protein sequence ID" value="ASIC019222-PA"/>
        <property type="gene ID" value="ASIC019222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019222"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013408"/>
    <dbReference type="OMA" id="AQGLQWN"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23529">
        <property type="entry name" value="GH19118P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23529:SF2">
        <property type="entry name" value="GH19118P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="462" mass="51052" checksum="8228CF4F7A6521CC" modified="2014-10-29" version="1">MSGFGKQLSCILSSILLLFCGGMHIGWSISHLNMGGNAWAVGISVDEFRFAILSFFTGCGFIILIVAATKQMVPTRIWLVLSAFFFMINGVFFTAMPTYYAATVATRIIAGFGHGICHVVSIIYVGEIASRNFRGKLVAILVSSIVGGVALFTVLSMVTTNPIFIVEPNMHANRAIGIVILSLSTLALVPAWFLVIESPLHTLTTSGNETLARSNLLKLRGLSVESPSLMDEFEDMKTLAAESESLSPFFLSQGNFPAFQLALLVKLANLLFFNYSMNTAKMSLMSLMFTLTVFTHNWAPPMLWLSKFAGSVLAIFIIDLLPRRFQYGFSSVFTGSFMLALGIILATYDVVETWIPPFLYMVAEVFNTFGMLPVPEIMLSEAFPPKKRALSVSSILICEYVGHMVVYIIYFNVPSTLSNVYIKTLVFSGVILLKCLIAVLTTPDTRNKYPREAVHLYMHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLI1</accession>
    <name>A0A084WLI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019130</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019130-RA">
        <property type="protein sequence ID" value="ASIC019130-PA"/>
        <property type="gene ID" value="ASIC019130"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019130"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019130-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8007" checksum="DA1F100CA2CEF168" modified="2014-10-29" version="1">MEYFLRRYTTFKTGVAGPETPHGGVTTTETEKKPTHGRKDTFRGFHSSFLGHVLAIARGIHETERMEAGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM36</accession>
    <name>A0A084WM36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019330</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024373">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019330-RA">
        <property type="protein sequence ID" value="ASIC019330-PA"/>
        <property type="gene ID" value="ASIC019330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019330"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019330-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11705" checksum="731350BC7D1CB094" modified="2014-10-29" version="1">MYYTHCEDNYSCVAENQRRLISVRAERQIICARKKIAPHNSHFFRHLGHKRVTTDTPENGMNGGFPVLFNVLDDLPRQVEGKNQTGRGQTTRKRSTVPHDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM37</accession>
    <name>A0A084WM37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012152-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019331</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024373">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019331-RA">
        <property type="protein sequence ID" value="ASIC019331-PA"/>
        <property type="gene ID" value="ASIC019331"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019331"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018256"/>
    <dbReference type="OMA" id="YLPWKDR"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019331-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="500" mass="57366" checksum="E0D20969E995BAEB" modified="2014-10-29" version="1">MNLNYFPNEVLCRIFDYLPWKDRQRVSLVCCRWNDIINSDHYIRHQKLVLYNYNKARFFSGVRVELLNRQKHIELNSNAMLDTEEVLQTIGESFGGGEALVSSLSFVLRSEHRVAFGLVLENLPNLVHLKELNISANGALRKGVRIDSARLEKLNISFYQNSRCTLHTPNLHTLHLTVRYRSEMELLRTISGQLVELQVSFISKDHVAKLFDCDCKSLKRLSISLRNDKYIPYSVSPVLLRPLDKEGLFARTIVGLESLEVVDVCHIFDIDFLQMFIYAKSLKTLVINYIRLTVEVNQLINGFQQLKNLNLEGCPKADEPKELHLPALETLVVPYKHLSLFESELKLLTTLYYSNATKNQCQFIKQIARAFPSLSFLCLQNFDNELDSNAFSNLTLLTKLRTLVIKDMSVASKIFTNCPNVPHLERLVTDTIVSEVSMLDAIPARFPALLSFVIDNCFLYLIPSESGKHHMTFDGLRRLMPHCCVSTKDSTIFTEKDGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMG4</accession>
    <name>A0A084WMG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006633-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMG4"/>
    <dbReference type="STRING" id="74873.A0A084WMG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019885-RA">
        <property type="protein sequence ID" value="ASIC019885-PA"/>
        <property type="gene ID" value="ASIC019885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019885"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008174"/>
    <dbReference type="OMA" id="YVTRYLW"/>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000193">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000372">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="509" mass="57023" checksum="DECCC71E83DAFE4D" modified="2014-10-29" version="1">MKINASKMATPIEEKVDQNLKTRTGMVMISDGKSKPELARLHLSMEMITIQRQDTTTPAPTPTNATHPPIESRERMVQITRQKVGGLGLSIKGGAEHKLPILISRIYKDQAADATGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVVLTVKHYRAATPFLQKQLSRETPESDNDATCAELKADENWKSVNSSRPVSISSEPENRWIDLVSVPLMMAYVTRYIYGTDKLRPNAFEVRGLNGTTTGIIHCDDLAILSQWLKYITDNVVGLTSLQMKLFNRNFPVGERIEYMGWVNEGVINNHISWQSYKPRFLVLKGTEVMLFDSPPLNVTGLTKANVAYKVYQTMFRVVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVTSVIKLGRKTFAVSHHGKTGGLTLDWQAGFSLTEGAEAAIIWQYKFSQLRGSSDDGKSKLKLHFQDHETRTIETKELECHVLQSLLFCMHAFLTAKVASVDPTFLSSIQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPD5</accession>
    <name>A0A084WPD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001780-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020266</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="KFB52079.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
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    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
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    <dbReference type="Pfam" id="PF11547">
        <property type="entry name" value="E3_UbLigase_EDD"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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            <begin position="1279"/>
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    <sequence length="2962" mass="314261" checksum="F93C2DD19F484CDF" modified="2014-10-29" version="1">MSTLHFVVHPLPGTEDQLNDRIRDVADKINKYGVQTLPGLQSLKVPVKQIVIGPAHLGILLEDGRAFRVAFSIIPERLDLSKQDASKSNNNSKTTPTSRQCRSRTRIMRTSSSMRGGSSSQGSGSRSTGVIMGSGSSGSRSIVSVPAPFVPEELVAQAQVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEGGDDTEEGSDNYVAEDLISLLDGGFHPDNSVIIDAEAMFSEDVFGFSNIRNLMLYSRARSERNQNNSSSASGSGSGAGGSASAAGAGGAGSGGNGNDGPVAGSRSSGSGQSGPGNGTGGSSSSAVVSGSGQSGGPSGGGGGGSGGGVGGPSGVSGGAGGLSSAEREGFGRWRDRQYFGPRRWFQSGREDVWEKDVGDSKKKDYSSGYPLWVSDEMEPWPERNQPVRFTEIASLYSEFIGVTARGELHQWRWADVEPYRSNDSPDVHHPKTVPLNLQHEKVTQISATLIRCSVATEAGRIATWMDELLGYAGNKLEHVASNYPEFNLDRIVSLHTCTLYTVARTESGELFWWGVLPFGQRKRLWDKYKAKAKKPVRPSVNMPEVTVGAQVCMKTSPMYQHGAIGFTISNGVPKVGQLMNPAWDLTNVGRFKLLSMSTLSQQLAANSKGGSSSSAAGGTGGGLGGSGLSAASGGSGSSAKQGGNNKESADRIDMPPPPSPASSTCSDTGSVTNSHKRQKRMTLKEEPDPKKDEEQWLLKDVIFVEDVRSVPIGRVVKVDGDYAAVKFPPPPGTTSSSSSSSSNGGGGGGGGSNSKDKFDDSIDAWQDCRLLPKDALQVIKSATTPRVPDCFQKIPRRIVLSPTSTGAGSGGGNGDAPGGGTSQLLTIAVDSKGIHAIMKTGSKLHYSLFNLNTGRQEQDSAFPTDLGSFLGASPHQEVSLTCAGDCSESVLLLRDGNNTLYPMAKDCVDAIRDPSWLDLPPIKCIAAASLTLPSVGVNLKSQVALVVLAPEQQHLMSKILRCDVEGVRQLLAYLAAGDGQDVKSHHLASILNEHTDGNRNIIHACISMCSPTSNREPEFTSSGGSSNGGGAGSSSGGGLDSINVITSSMMGNRPVSIREIMRRNVINRELVLEGANLMQNNVGGSGSGGGNSMPVVYWPPEYDPTSGDEDSLGGLNSSVASGSSQQQQQHGQQQYSSSQKSVAMASIAETYVSDPNERRQNALTIVQLLCESAALQPHLRTLLCAKDAQGQTPFMLAVTCRAYQAGITVFNAIQRIANGDAAVRNSMIFPVGSAPDQSPLGILCCNDTCSFTWTGADHINQDIFECRTCGLTGSLCCCTECAKVCHKGHDCKLKRTSPTAYCDCWEKCKCKALIAGNQTKRYELLCKMANETDLVTRFNSRGEPILLFLIQTVGRQMVEQRQYRATSRVRSSSGNNARKTPNLESDSEMPEHNLEPPRFARKALDRLLHDWPAVRAMIMTGAEHEKPVVPNVNQQPFYDDDNQQVFLQSQSGTTLLDKFTHSLIVRCSSDPLEKLLVTLVTELQDETIPGRAEEAQKVARRFVRSVARVYVIFSIERFHNPEKQRNSTTQTKHLQAYRRVFTTLFKFAIEELVEISDALITPVRLGVVKPIAPFSLSSNNIDSTDDLFSVEPLAPPTNRSGGTSMVQIANATANDDGETSEQEDMAEREQPPPRRSSSLRPVTSAVSMNAEEESQDPLRNEENAQGESDNEFHFHEAETESDSDDNQSTQDAQRSVQTGATAGSDTGLNSLLFDNEDDSGDSTQPDDEGSEDGESDDQSTVDFNLNDEQLERRQTPGGNQRSNLAPQSMQWAIRSRDTVVPERVRLTTGGSNLVFIDPTTLRRSTAAVTAAQQQEAPTMTTTASALARAFGIILRQISDLVGMLPTTMTGTSSAVDVTHQEAVQLQMYVEKRLKPTWEWILTVMEATEAQLRFGASLTDSTDPSHPLHPLNIPAASSSTATESVAGTGMLPSGSSMSADSESSRRDFLTYCLSLMRAHNSEHRDSLPVLDVTALRHVAYVLDAILFYMRATNEFDIDRGTSGSNVWGDDQDENENEETEEEISTSIVMDTDSVDEDVLARPSLGRRHSFFQRSDSTLCLGCPAPDPFNTPLTEALPLADQPHRLQPNAKREDLFGMPKRPITLPPNGGAACGSGGGGVGYSAASAQNASAGFAGVMGEAAVVGSNGGGSGTGANLELPPVRLSLSSSIRNEPSNDQADGMIVDPTEAMYVDQQSQDQAVPFIGGAGGGANVQPPTSPPPPSTDSRVRVEISLPVGIYQATSGSTSSAAKAQQELMDAVGAAGSSSGGSASVAIKSGETLSPKPPPPPPPPGHSSSSSSSSGSGVGAGSSSSSSSFSSEVYYKKSRLFYTKNNKYSEESDVDEVSISSDEPHDLSQSSLKLDVDTDQDHDELSESDSEDSRPTAVKRQKMNDGSDVAISDEAAGGVSLVMSQQQQQQQQQQGDGSSIVQQQHQQQQHQHQQQPQHVQHHQQEASSAIRPPIIVTRRKVAMAAEAAGRGAVAGQGGLDASMTLGQNSSAASLLASDVGMAGDQASGSSSSSSSSSSGPSVSFANPLVTIGGSPGAAGSSPGKSVIVRAGSSSSTVFAASSAGISNSNSSADLIQPAEAMDIQEISAHVTVETTPNVVLTVETAANSVVPVAPAVQPEMPPRGYYLRGASSMHSSVLSYILLGRWRLSLNLFARVFLEDVGIEPGSVIYELNGFPVKEAKFRRYMEKLRTSCSHQKDLTLSKMERNRAALLSQTFKELNTLYNNRRVQQPLMFSRVKVTFKDEPGEGSGVARSFYTAIAEALLANEKLPPLDTAQTGPGKYGPGPFNSMLQRHRGSSSGGSGATGSVAGGSATGGGGGSSGGPGGSGGSGSSSSRRGLSSKQPLWRPNREPRKTLNYDARPFRPASEMNAGGSSGGQRRRPPVAATVVRRSCTSVTACRCSTSSSANASTRRSTSTIRAMRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPV4</accession>
    <name>A0A084WPV4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00020362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPV4"/>
    <dbReference type="STRING" id="74873.A0A084WPV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020362-RA">
        <property type="protein sequence ID" value="ASIC020362-PA"/>
        <property type="gene ID" value="ASIC020362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020362"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016781"/>
    <dbReference type="OMA" id="MHIGAPR"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785143" description="Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial" evidence="6">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="7">
        <location>
            <begin position="82"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB52248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="23260" checksum="054CE307BE966289" modified="2014-10-29" version="1">MMTIRPLLTKALLLPSANGATQILRSKATLPVVEKDKPEKVSYSPFGTKQSNWADWTVARLDDVLNWGRKGSIWPLTFGLACCAVEMMHIAAPRYDMDRFGVVFRASPRQADVIIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIIPVDIYVPGCPPTAEALLYGVLQLQKKVKRMKTLQMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQL6</accession>
    <name>A0A084WQL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009214-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00020757</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQL6"/>
    <dbReference type="STRING" id="74873.A0A084WQL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020757-RA">
        <property type="protein sequence ID" value="ASIC020757-PA"/>
        <property type="gene ID" value="ASIC020757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020757"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015781"/>
    <dbReference type="OMA" id="IKPICVQ"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785112" evidence="9">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB52510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="347" mass="39365" checksum="DF8A90EC75A22E01" modified="2014-10-29" version="1">MQIAKLLFWLLLIIAYQTVIATPDKCDDGYECIDIRKCDRFAPHLNRPDMWTESLTEELRSRICITPEIATNNVFTVCCEKVKRRRDELLDLEKCGVDNGTAYGSETQLYQNPWMALLYYQEGWRCAGTLINERYILTTARCAKDQTLKHVTLGEFNLSEPIDCDQSGMRCAPAPQNISIERVIIHKDYYARPKQNNIALLRLAKPVTLNENVMPICLPVTPAMRKHSLKFSAVGWGRTENCVMSSSLQRTKMELLSQDVCNMWLSEKAKHIRHTDTLVCASGVLSANGLGDAGGPLQTISNSTGRNRYVQYGIFAYGTAFCGNVHYPGTYIRVESFVEWILDNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSN2</accession>
    <name>A0A084WSN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003232-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021534-RA">
        <property type="protein sequence ID" value="ASIC021534-PA"/>
        <property type="gene ID" value="ASIC021534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021534"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013865"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="16422" checksum="75C6F0A68A5B8A70" modified="2014-10-29" version="1">MFWFPFHNLKLVAKLPKXXXXXXXXFLERFKQLSEKIVKQTEDQVKPPPSEEPDATASSEPVPLVGVSAGPSGEQMFKFDVPPPSLLPTLPPPPPPPPPQLPEMADEVHFEPFYDLPPVAPTVGSPSVDGGADEVGRHETATGEVETNFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSU3</accession>
    <name>A0A084WSU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021627</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026718">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525418">
        <property type="protein sequence ID" value="KFB53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021627-RA">
        <property type="protein sequence ID" value="ASIC021627-PA"/>
        <property type="gene ID" value="ASIC021627"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021627"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021627-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="9094" checksum="F31CAC9EC1CFB8DE" modified="2014-10-29" version="1">MDFRRADDRGQGSCKRRLCNVYELWRQSERGQFNEQVLSLLSPQVSKGDRRQTRSTRPITSMRRTLRPMSGQSVHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT79</accession>
    <name>A0A084WT79_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021905</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021905-RA">
        <property type="protein sequence ID" value="ASIC021905-PA"/>
        <property type="gene ID" value="ASIC021905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021905"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7476" checksum="7E6C17B521FFD317" modified="2014-10-29" version="1">MHTHTGDFRELGTKAQMDNPFETEETYSASTGSISEQAHDRQQDGQPRAAAMRCIEACHLGLAAPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUN0</accession>
    <name>A0A084WUN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010845-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUN0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022166-RA">
        <property type="protein sequence ID" value="ASIC022166-PA"/>
        <property type="gene ID" value="ASIC022166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022166"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10755" checksum="6AA368D2592BDE61" modified="2014-10-29" version="1">MVKDKGKVKDRDRDKAKDNGKDKDKGRDLRDLVVAKDNSSNNKAVRGQTELKSRDSTIINTKAILERASIRASTRVASKDCKGDNIKDNIKEVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUP8</accession>
    <name>A0A084WUP8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00022188</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUP8"/>
    <dbReference type="STRING" id="74873.A0A084WUP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022188-RA">
        <property type="protein sequence ID" value="ASIC022188-PA"/>
        <property type="gene ID" value="ASIC022188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022188"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020401"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020876"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000321">
        <property type="entry name" value="Solute carrier family 45 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
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    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
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            <begin position="51"/>
            <end position="76"/>
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        <location>
            <position position="523"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
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        <location>
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    <sequence length="1080" mass="120013" checksum="6DEDD4438DDE7267" modified="2014-10-29" version="1">MYGTYQQHGRLSEDEVLQGMLTQRHRYANADPTRGYQHSFRTKSKWELVRLSLMIVGIECTYATETALVAPILLGIGLPHTIMTMIWAMPSIAGLLFAPVIASISDRLRSRWGRRRPVLLALGATTLTGMLILPNGTAVGRLLGLDSIPWLATITTIGLVMSDFSVETSNGICRTYAMEVCTVRDQTRVLSVMVLTGGIGATMGALFGAIDWDTLGIGEFFGGNDSSVFAANWIVLFVGLVVTLTSFPEIPLPVQESDPMLRPVTQKMLLDEVRRVNGEKGEVEVDDTPEVVGFRQFVRNVLQMPRSMKILCLTQLLSHMSYLTYCLYYTDFVGATVYDGDVRALEGSPAAERYADGVRFACLGMALCSTTSSIYSTFIERLIERFGARPVYVCGLLAHSIGMLAMGLVPHKLVVFLCCSLTGVMYATIYSIPFLLISHYHSKNCGGCEWNGVDRQCCGACCGSRSHSKLCQGEPFALLGRLRSSTPSTLLEMNLVKNMPNKGQRDKWGKDIEFLLSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLLLVGRPIYYLEMLISQFSSRGCINVYDASPAMRGIGVGQTYSTFIVMTYYASLMAVTMRYLIASFADPLPWSECNDAWNATCIDSRLITNMDENSTQAAVTSAELYFVKDVLKEADSIHDGIGIPDWRLVLCLLVPWTCICLTLIKGIKSSGKVAYFLAIFPYVVMLVLLIRACTLEGAGDGMLYFIKPQWDRILEAKVWYAAVTQVFFSLTICFGNVMMYSSYNRFTNNVYRDVTIVSIMDTLTSMLAGLIVFGVIGHLAHVLEAPDIQQVVRGGAGLAFITYPDAIAKFTFWPQFFAVAFFLMLFVLGIGSNVGMATTIMTVIRDRFPHLPPALVAVGIAIVGFSIGVIYTTPGGQYLLDFLDFYGASFVALVLAVFEMMTFAWIYGVSRLCRDVEFMLGIKTGLYWRLCWGFITPTLLAAILLYHIATYESFTFNGYVYPDGMYAFGWCIFAAGVLQLPAWAVYTFLKRKEPDWRDRLVHCFKPTHDWGPEDPELNAKYHESVYKAEQALPRNRSIARRIYDNVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA45</accession>
    <name>A0A084VA45_ANOSI</name>
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            <fullName evidence="2 3">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ZHAS_00000356</name>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Pterygota</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
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            <begin position="47"/>
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            <dbReference type="EMBL" id="KFB34839.1"/>
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    </evidence>
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        <source>
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    <sequence length="71" mass="7912" checksum="1DAF55DBC51D7E08" modified="2014-10-29" version="1">MSQQQKHAKGMQQIPVEGPLSCKRKDTLDLSGAPPQKLVQKQLENGAGSSKGKQLQKVQELRELVWIPHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAU6</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS015544"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016768">
        <property type="term" value="F:spermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="spermine synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015576">
        <property type="entry name" value="Spermine_synthase_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315:SF1">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="121"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="374" mass="42919" checksum="E5120692A72D1EBF" modified="2014-10-29" version="1">MSANTVLLDFSLDPARINDEVSRKDIVRLCKEGLEKYLTGLKISYDMLTADGYLCILNESSSGTIVTIRFFEQGLITINVEYYRKDGDEPKLSFEQTRELENSLVQTLKLNHGQSLPPLQRGPLTRFFPTADERVIEYDIDRVLYDKRSEFQKIQIVHSKSLGNMLVLDELQNIAEADLIYTETLMRRGVEDYAGKEICILGGGDGALLYELLKEKPKHVVMLEIDDMVMQACNKYMNSICGDVLEKRKDDNYEIIVDDCVRYLHKFSQEGRKFDYVFGDLTDIPISDTPTGEIWDFIRKILQSSFKVLKPDGKFMTHGNGVSCPESLKMYEEQLVKLDPKVSYTKCTAFVPSFMEEWVFYQVQREDTNVAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAW5</accession>
    <name>A0A084VAW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006439-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001005</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01004650">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524229">
        <property type="protein sequence ID" value="KFB35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VAW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001005-RA">
        <property type="protein sequence ID" value="ASIC001005-PA"/>
        <property type="gene ID" value="ASIC001005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001005"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013281"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="11657" checksum="6562FBBA933CAAC9" modified="2014-10-29" version="1">MILGGGGEGGVGGVAFDPSAGRGASGAVISKRDNSVVPSGLRDADASDNEVDSRGGNLVRRNRPRQELGPTADPPNRIPVPPAVTGTPKPPTTELDDLLISVKXXXXXXXNNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBC3</accession>
    <name>A0A084VBC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007824-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00001441</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01006327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524352">
        <property type="protein sequence ID" value="KFB35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBC3"/>
    <dbReference type="STRING" id="74873.A0A084VBC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001441-RA">
        <property type="protein sequence ID" value="ASIC001441-PA"/>
        <property type="gene ID" value="ASIC001441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001441"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001250"/>
    <dbReference type="OMA" id="NHYGITT"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016360">
        <property type="term" value="P:sensory organ precursor cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19715">
        <property type="entry name" value="bHLH_TS_amos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="306" mass="32577" checksum="A85483B8B9F3B2C3" modified="2014-10-29" version="1">MSSAYVQQQYNHSAMYGGGSVMGVGGGGMLESSVYNHYNPMNSMNSNGHCYGYGTDSGASEGYHSPGPVSSPESYFNNTSPAEYSPDSPYTSYGYCSGGSNVGVHGSVATVTNGANNGSCDPYYGYTSNSFKTACPTVPQYRTPMTEPSANSYERPSMSDFPKREPTTVTHDSQSAVQPTISVTAGKRPPATAPLAHSGGPYYNPYALPAARIGCSPTHSSGSSVSPTPSQCSGQSVGIVQPEVVKKRRLAANARERRRMNSLNDAFDRLRDVVPSLGNDRKLSKFETLQMAQTYIAALNELLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCF4</accession>
    <name>A0A084VCF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002505</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524597">
        <property type="protein sequence ID" value="KFB35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002505-RA">
        <property type="protein sequence ID" value="ASIC002505-PA"/>
        <property type="gene ID" value="ASIC002505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002505"/>
    <dbReference type="OrthoDB" id="10427417at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759800" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002505-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="11699" checksum="E3FB83FD7777760D" modified="2014-10-29" version="1">MSAKTVTLLLLLYEITFTSSSPSFQGLLEPRRVLGGSGISNGVGEAMLNKLGTMQPKTTELPSVVSPTVNAVQKYASELLPTALTSFANNNESSGMNSFSNATDNTVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCH7</accession>
    <name>A0A084VCH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP004104-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00002571</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524612">
        <property type="protein sequence ID" value="KFB35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCH7"/>
    <dbReference type="STRING" id="74873.A0A084VCH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002571-RA">
        <property type="protein sequence ID" value="ASIC002571-PA"/>
        <property type="gene ID" value="ASIC002571"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002571"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009320"/>
    <dbReference type="OMA" id="WICNTIP"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="112"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002571-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="578" mass="65256" checksum="767E0CCBF9425B70" modified="2014-10-29" version="1">MSATQEDGEAGGSDAAFDRIMESIGNDGPFQKRYNIIFNVVAILFFAMTVVNVLLILAVPDHRCSIPPETDRNKTLAEHWEDIVYPKEYNSRGEYVASSCLMYNVSFENLDLLPTNSTTSCIYGYEYDRTYYDRTPVTEENWVCEKELYGTNVFAIVRVSEVCGTFILGQLGDRIGRLPVYLFSILTAVVGRVFAIFTARQYWLFAALAFIGSFSTNTSFQSPLIIVMEISKDANRAALSLWQLVGWTAGVCLAPLVLWWMRDWFWFMIVTSLPCLLFYCFPQYNIESPRWLASRGRYGDCLKQLRKIASVNGRPLTIDEEQLRALVPRPEIERTYGIASLFSGWHMTKLTCLLLLSWICNTIPTFTLFLMSLQMGGNPFLNNFWQGAVELPAYLLGQICCDRLGRRFTNSGAFLGATLACLPVILLIHRPGNELYVTMLAIVVKFFICVTYFALYLQSVEMYPTSLRQTGASFGIIMANVFGALGPYIVFLGTNYDIRLPFVAMALVALVGAVSAIFLPETLHQKLPETMEEGRQFGRDQRFWVVPKRPAAPVESRAGEYRTPADQQELTKLNKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDS9</accession>
    <name>A0A084VDS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003167</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524715">
        <property type="protein sequence ID" value="KFB36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003167-RA">
        <property type="protein sequence ID" value="ASIC003167-PA"/>
        <property type="gene ID" value="ASIC003167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003167"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6751" checksum="EA8AEB647C36BE57" modified="2014-10-29" version="1">MAYEMRFVPIPAWASPEAGIISYLPRNTVNRMVVLGHQMERGAINTSKFTDPDRPSCDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEY8</accession>
    <name>A0A084VEY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003669</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524784">
        <property type="protein sequence ID" value="KFB36532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003669-RA">
        <property type="protein sequence ID" value="ASIC003669-PA"/>
        <property type="gene ID" value="ASIC003669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003669"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9705" checksum="C3573FC38EF6C197" modified="2014-10-29" version="1">MLHHFGSRLPGRMGQFGAAHQSWGGPWPPSHRHPVAASGWLLDVTVERPAGCNANAQCESFHSIENNYSQIIFGGNVVREAAEWRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG23</accession>
    <name>A0A084VG23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004088</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012605">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004088-RA">
        <property type="protein sequence ID" value="ASIC004088-PA"/>
        <property type="gene ID" value="ASIC004088"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004088"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004088-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="174" mass="19123" checksum="E7329A388BB07FDC" modified="2014-10-29" version="1">MGTIPSCRCRGKNFSHDSTRHQRAPGSNQHHAIAMMVLPFEVIGICGEAKIGPRNSNGKKIITITARFSINAEAGCHYCRRRGALPSDRGDRRSGDDLKTNRSAPFLTANINLTRALAKVGEGVKMLIKNRLPCWLVDGTILFLLHLHFLRKRQHKGIGADGAGEGFLQGREAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGK8</accession>
    <name>A0A084VGK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP003780-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00004327</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012993">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524833">
        <property type="protein sequence ID" value="KFB37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGK8"/>
    <dbReference type="STRING" id="74873.A0A084VGK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004327-RA">
        <property type="protein sequence ID" value="ASIC004327-PA"/>
        <property type="gene ID" value="ASIC004327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004327"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014029"/>
    <dbReference type="OMA" id="AHMSGSC"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="461"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="620" mass="68649" checksum="55E24DDBF702C880" modified="2014-10-29" version="1">MRRLWIAAILIGTFGVLTANGLFLLLKTLAHAGRYLNDHYDDGYRQVQEYDFVIVGAGAAGCALANRLSENPEWKVLLLEAGPGENELQNIPILTTFLQNSQYNWADIAEAQNTSCYGMIDQRCSLPHGKGLGGSTLIDYMLYGRGNPADYDRWAQMGNPGWSHADVFPYFLRSERAALRGLENSTYHGTTGELHVEFPPFRTNLARTFVAGAREAGHRKLDYNGKSQLGVSFVQTTGRNGMRQTAYRAFVEPVRRDRPNLHVQPYSQVLKVLINPDTRTAYGVSYARNFRNYEVRARREVIVTAGNLNSAHLLLLSGIGPQEHLQNFHLPTVSNLPVGQSFVDSPVFNGLTFVLNETGQALLTDSRFQLRSLGDYFRGQGPLTVPGGVEAISFVRTENATTEPGVPDVAIVFSTGSLVSDGGLGLRKGKRIKTAIYNKVYRPLEALRNDQWTASIVLLHPVSRGHLKLRNANPYGALKVYPSYLADERDVEALLAGVKEAVRISKSPAMKRYDARVLGIPLPNCEQWDLRDDDYWRCAIRTLSSTAYQQMGSCRMGPPGDPLAVVDPDLRVHGLQGLRVADVSVVPTTISAQSAAIDYMVGERAADIIKAQWQQEQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIK1</accession>
    <name>A0A084VIK1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">LOG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004961</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIK1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004961-RA">
        <property type="protein sequence ID" value="ASIC004961-PA"/>
        <property type="gene ID" value="ASIC004961"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004961"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004961-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8627" checksum="0CA91714556E14C5" modified="2014-10-29" version="1">MAGGWGGTTSRGPFGCISNACPHHHKSRLDLEMETVIRLSNEFDSGFLGDPARYQRVATSNPAGRSERFRAYFAPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJF7</accession>
    <name>A0A084VJF7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000320-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005376</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VJF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005376-RA">
        <property type="protein sequence ID" value="ASIC005376-PA"/>
        <property type="gene ID" value="ASIC005376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005376"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009628"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:transport along microtubule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
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        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
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            <begin position="36"/>
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    </feature>
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            <begin position="80"/>
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        <location>
            <begin position="668"/>
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    </feature>
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        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KFB38101.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="692" mass="77243" checksum="383941165CDF1E2A" modified="2014-10-29" version="1">MDRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKEKEQKDLEEAAGKLGHSETSTRKDLDEMLSSLGVAPVSEVLSSLSSVNSATSDHSTTHTPDASLQPSINGQNYRKKPVNLCLVSVQATNIPPKETVVYSKQTQTNSSGGHERDGNFSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTGDDEESSLTHIDHGFHSKLPPGILPHGLPTVKEVAPAITPQEQKKEDSKEVKELSAEQKQMIILSEDFQRFILKAGKVMERALSETVDIYTDYIGGGETDDINDEKSHARLSLNRTFYCDRWSKNRCVTSFDWSTHFPELLVASYHSNEESPNEPDGVVVVWNTKFKKQTPEEVFHCQSAVMSTCFAKFHPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSANAHTQPVYCLSMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDVLELQHRQSKAISVTCMAFPHNEVNNFVLGSEDGYVYSASRHGNRSGIGETYEKHLGPVTGISAHHNQSSPDFGHLFLTSSIDWTIKLWSLKDNKPLYSFEDNSDYVMDVAWSPIHPALFAGVDGSGRLDLWNLNQDTEVPTASIVVDGQPALNRVSWTPSGLHVTVGDEAGRIYVYDVADNLANPRMDEWNKLNAVLYELKMNQTDEFDEMDKKSPIPQNPTSLTSLAGPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJJ1</accession>
    <name>A0A084VJJ1_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC005420-PA"/>
        <property type="gene ID" value="ASIC005420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005420"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9573" checksum="CA519549CDFDA9E9" modified="2014-10-29" version="1">MDCGMCGWHGKLYISPDSTSHQPDRPKFQDRPQGGRALVRIGPAGRKIIASNLKATSSRAPKKRTAEAGSPFAQAQRVRFVHAHQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJM5</accession>
    <name>A0A084VJM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005477</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005477-RA">
        <property type="protein sequence ID" value="ASIC005477-PA"/>
        <property type="gene ID" value="ASIC005477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005477"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7376" checksum="0A9F301025809B2C" modified="2014-10-29" version="1">MRFIDTLPPDTDDILDEPAVSVGALDELPKSTYQNQKTAHQTKSQSLQMLLQLMNQDDPYKNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJU6</accession>
    <name>A0A084VJU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Dwil\GK12675-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013885">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013886">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJU6"/>
    <dbReference type="STRING" id="74873.A0A084VJU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005594-RA">
        <property type="protein sequence ID" value="ASIC005594-PA"/>
        <property type="gene ID" value="ASIC005594"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005594"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016528"/>
    <dbReference type="OrthoDB" id="6354602at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001606">
        <property type="entry name" value="uncharacterized protein LOC108091111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF12">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 14, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="367"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="473"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005594-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="615" mass="67330" checksum="1728E618F6416754" modified="2014-10-29" version="1">MIAHCVSSPDQTERRDPQYRRPAFADDIQNGSQIEPFSGYRTGTKQGHLSAGEQRAIVGASSIQPLIEQDVYDDDEEESEGDEGEGDDRRAVTVDDSGYEEGYDNGNVIIHDDPVRLPTHPSSARLRSTADPAGELKELNGLEAIENSFSSTSANQHHLHQRPRASQQQQQQQQHSSADDIVQPPSPLLILTTAADGANSLSTTDLAGLTVSTAVEVDAAPGAVSLNESLSNRRATRRPTNAQAAAMVQNMAYISTPVLTAAAIPHNEASKLPQNLPQVQHPTTGGPGSAVYSDMVSGTLAPFSTVAAQKHRTINSMNLNPTTPAMVVKPVGEHRKLLKSTGPILNYVFDHHPPYYKSNYYNARYGPHFETDNVTNITVQNGDTLFLSCRISLLQDKTVSWVRRKSGETALQLLTVGKQTYSGDSRYQIEFQYPNNWRLKISQANKNDEGVYECQISTHPPKVIIYYLHVNAPEVLIVDEEGGPLYDKYYEVGSTIKLMCKIRHISMLRSVVYWIHNENILNHDTTRGGISVKTNLTSVGANSTLFVAKVNRQDSGSYTCSIGPNQHYSISVHVLNGECVYSETPPKGDPGEAKVNLHLAPTTGGNANHSIDRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK87</accession>
    <name>A0A084VK87_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Bromodomain adjacent to zinc finger domain protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00005735</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524944">
        <property type="protein sequence ID" value="KFB38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VK87"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005735-RA">
        <property type="protein sequence ID" value="ASIC005735-PA"/>
        <property type="gene ID" value="ASIC005735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005735"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003121"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005066"/>
    <dbReference type="OMA" id="KLGHECI"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain adjacent to zinc finger domain 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF2">
        <property type="entry name" value="TOUTATIS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MBD" evidence="17">
        <location>
            <begin position="888"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="16">
        <location>
            <begin position="1200"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="2858"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="3301"/>
            <end position="3371"/>
        </location>
    </feature>
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            <begin position="142"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="789"/>
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            <begin position="1029"/>
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            <begin position="3193"/>
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            <begin position="143"/>
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        <location>
            <begin position="315"/>
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            <begin position="327"/>
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            <begin position="858"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="1029"/>
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            <begin position="1493"/>
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        <location>
            <begin position="1576"/>
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        <location>
            <begin position="1600"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1686"/>
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        <location>
            <begin position="1749"/>
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        <location>
            <begin position="1797"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1845"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2011"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2054"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2085"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2145"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2230"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2288"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2797"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2978"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2997"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="3069"/>
            <end position="3086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="3102"/>
            <end position="3120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3394" mass="360484" checksum="48107C325216DDA8" modified="2014-10-29" version="1">MDKEGDKKGGEKKGAYWGRDPSAMAAAAASNPLFGSQFGMPGGLGGLMPNAGTGSGSGNDRFAMSHHNQNTMAVAASQAASLAGLHNSWWSMAQLAAQDYFARLQASGMASQLPFSHDLAGAFPGLGLGAMNAAAAAAAAAASGGGSGSTGGGGGGGGGGAGGGNSGKGGSGGGKGKKRDRSSNSNSSNASNSGAGGGGSSGGMSGGGMGGAGGGGGNNSSYKVSNGEGIIQHMMEGTLITPTTSNTFTVSLGVPFCPALRQGCPFTRFHGGGGSSKQKSSGGGGSSGGGGGNSSSSSMTSSSPHGASRLIGNDSISITRGSSSPSVNASKQQPTPSVTISASHGGPGSSQQNHLQGLSSSRSSKDGGGGKGGGLSASMNALSTLSQFNNLDLTSQQNVTATMNALVASQAKGKDYISSGILSDPSSLLGVRLPPDTEIIKYTSSIVGPKAPGTGGRGPKRQRLEQNEFGGGGSGGGGGSGGNSGASHLGSSLGMTSGGSVSSGGGGLLPPGLSHHHQVGSNGGIGGLGSSGGGSGGGGASNDRIEVIKLPPTITSNGVYSAGKGSGGGKDSMVDHMNEWAGLNLSAKGGSSGGGGSSSAAASIVSSLTAAAGMNSGGSNQSSSMLEQDDAPLNLSMKPSKGGSSNDGAGRGDSTSSSPAISGASANSLQSLSTITAALGGSGGGSDSSRSRRKAEGKNRRNAAAAAAAAAAAAASSLMTPAGAAAALGAAGANAAAGSLGGLDGMSLASAAAAYAAASPASTGASTSTLNSLLMASVGTSITSPVNTITTSSGSSGGGTGNTGVSSSSITSSSAANAANHQLMAAQLGFNSSLSELLKISNYRGEKLRQAMIEASRNQSMDNSTSNTNTDTESISESGMSESEGEEHINVKDLRVPLEKGWRRETVIRGLTKNGHIKGDVFYYPPQSVNKMKGMNQIQLYLDQFKPKDLNRDNFSFSAKAIVGTFLQPAPPPYATDGEFIKMTDVEVGRRLEELKMFTRHAALGVEQRIEIAKQQQALRDAKKLAKEEMNKNKEKARQAKEAERNERLEQQRKERELKNQQALEAKKKREEELARQKAEEAARKAQEKEQKRQQALLQKEQELAKQKELMYAMEMERERRRQHMALIKQLELRRKFEEKEKKKHQVILDKLIQREKKLVMRKRDTNILAELRKPQEDSEIVDQTELPGFSRIPGLKLTGTGYADLLMVFEFLHNFGETLGFDMESLPNLQSLHLALTSENAIDAEEELLSVMTHLLVCAIEDPGIPNPGRHTTLLGQTLRQADITHTNVSEILRIYLYAVATGEVKLQSGINLERDRDAPSKHHLVNDEDFKMCSTKNSQFYELLAENARYKLSELLKDKPFVALNPTTKTEILAMLCNDLLMNKAVCKQIDSSLEAQAQLKKERYLLDNKIRKYKMLVARKQRLEQYEKAQQAALEKSLSMKAAEEAKRAEEAAAAMAAAASAAAAAAVATSSEQPENASTTGEPKAIDSEVGNVNNGEEGVAVVENGPPTEGSNALPDETPGDAPVLQPPPILEGSRSGGELEEGEIVNKPDGEVIASGGPSGAGEDGNKTDDDVDDDDDDDDNDDVVEIVPMPVTCTVTEDSCPNTIPPSAEDEEQQAMNSTGVPAMNEVDHPTTESAPLPPADNNHHHPEPMNGIESVGESPSIPSDENGMVPQENHNHSHTTSENQSSVANPVTPPHTNFTPMVQQHKPMMQLEPGEIPPPGMDISALGGAYHHPHAAAATTEIPTISVPSTPEESPVKMGDHHHHQQQQQVDGTNGDANLKPLMPTCDLTGGGEQPQPGQVGGQPGVTPLHANNSSASELELLSKSMINDHATCGDRADEDNSDLESEGTQLEEDEDAHLTAEEAQRKYDKILETSFQNKQQLENALNQLRVKCFGQDRYWRRYWNLGKCGGIYVEAMESTQPDMYRYENALEEVQSRPDYVPKYAPAIKADNTAASGDGQVKQDPDVKPGTNCKQEQEGADGQGVKKEEEGAAGTEGTVDDRKRKRCSSVSLKKLKKKKKKPRTTSEGGTFGGHETAGYNDGGGAADEDDGDDEGEEGEEDEDDCSRTSYSNGPALEDGRTADSQSDDCKIIDEPEVVLTEGGGGGEGAPTGNNAEDHTRPAGVEQNPPLSEPVESEQQKVIDENRLENHQPSLGHGGDASSRPQGMESVPQNAASFPRKSDDQLMDIEDSIPTAILVQKGNDHDQTKTVEVNNQIGGVNVSPGGQPQSQPKPQQDDDDDDVTMVQEETPTITIPDDDTDSGDRMEGGAGGKASDRTEAGQRTGSEGGSSSMNCDMKPKLVENGVVELRDPGELVECQLQEMDDDEEIVPPGSGCRTNGGAAECKPNVGNESNGAVDRKPPKTTTSSVISYGSDVEMIEVKDEDSNAGVPSIPAPITPGSYLYLRNTDTKQEKEFSDQLLNRWFSIVDKELPLSSTECPLPTINGSTPASMARQIFTNITCREICQIQGNRWDIGNNIQFFSVPLEKGVEIHFPNESILSLSGLDDDEMQEVIAKKSRPEPLQLSDMKPAFKRETIEYSYSTNHPNQIRLRAELAEEPADPEEYGHFSLPAYMTLTLSNLTAYVQCDQFQPLQMTPEEEKQLEDIKIHGAPRKTDPKVVPREFRYGWWKINDIEELNDLIKALNPRGVRERLLRQSLLESLAESVNLSTPHHVSHPRAPPPPNGYIEPEAWNAWNPSIARRVEVALLDQIEAMEDKVASASMQVKGWQMPQREGDSENGAPEDVTIEMLRERILGLEAAIERRYLKPPLGINTTEAQMAVIAQQEAQHNQNNSNVSNLSNCSNSSAEDENLPKGLLSWRDAVERSVTTAQLSMALYVLESCVAWDKSIMKANCQFCQSGESEDKLLLCDGCDRGYHTYCFKPRMDKIPDGDWYCFECKNKATGDRKCIVCGGLRPPPLGKMVYCELCPRAYHQDCYIPPMLKHHELFVTFTYPFSLSSIHGANGTARIASPRHHRRKKPQRKPKERTTNNSSQSMLNSSLNSSQNQSLNSSHEDIATTPLSPAHSIASTSHEESSAPQHLQQHLHMPTGVPAAAMVPPPYNHQQQQQQPVHPHQQPQYSSVPSVDGVPVYGACHPPPPPPPATTQTLPPPPPVDQNMAAMYGQQQQQYYQQFYQQSGGQPLVDSTVLPPPPAPVPQQYYGTPTGEYNAAYAQHQQQYAHQQATVREGEQMASHGEGGNGEQANQATPMEGYAGAIPTGVETPHPVVGDNLGSQQMSLEGNLPLAQGDTPVETSVATTASTALASPSSMQPGGEYCLSGNTAAAAAVACGSSSSLHEDSWPFLLPVNTKQFPTYRKVIKCPMDLSTIKKRLQDLVYKSREEFIADVRQIFDNCEVFNEDDSPVGIAGHGMRKFFEQRWTDLTDKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKE8</accession>
    <name>A0A084VKE8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00005908</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VKE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005908-RA">
        <property type="protein sequence ID" value="ASIC005908-PA"/>
        <property type="gene ID" value="ASIC005908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005908"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005991"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006147"/>
    <dbReference type="OMA" id="YLLLMQS"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1835"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2125" mass="240201" checksum="D337AB6507855B5C" modified="2014-10-29" version="1">MATSLAAQLQRLAAPQTSVLVESRRKASILFDTKEAASKDREVIFDIGLSGLEELIQLNGAFARFEETLFDRNAMDLQRSVEDQAMNAMLDANVRKFFFHLSPYFMLQPAHKCLEWLIRRFNVHQFNRRDFVNFILPYHETRMFVRCIQTLQFQPTNDQLAFLQPLAKAGVPPSKRTIIEHFAAHPEFLKQYGKFLMEATTELGSKANALQAMFAFFCTTTLGVFESVESVTENYVVAVLRPVAAGLAFNAVDYASACYMIVGQLVTKTALSVDTLELLTKRLCCAEDPTQRTNAVMLLVLIFQTQHERLSPIPNKLMKRLISTSWIPQVLSEVKADGIDVLVCYRKILETSLGEICRSFHSIGFYSQICEQLLWEIALTDTEAEDIIQCVLDSYIGTGKQTAEKSKPPSKAMDDEDDETINLDSDSEEESFKSRHEKVTRWYSEFLKSLERQYPTPFDRVVKRAMKGQEQYSHRKRNALKNVLGFLLQASCDENEAYVFENLFHFDADRRSHAVKYIVENFDRLTSKRRGRLDLLRESISERLDDDSCVVVKEVLRLSPAQLLKTVGADALVAKLNHLTLKCAANQEHWKKVTGRVIEMLTNKQIYTSVNINRVIIALYPLLFPLGDDPVGQENVESLIQTPFSKQFLVPAFYGNTENCDVLLRTLEETGQCTNPVQVCFNILLLSSALPSPCSVDQADRVLRYARKQLTGHRFQYAMTSDLQCLTAGKLPVDLITVPIRHIIERVRFDPTSVDMSFDRQNAPLRLRLSIFSDLLQRYCIIDPQFTDLRAIFGNLLKTFLTQLYPDLGDRVEFLSHFYTVHLIERRTDLEQEENSLSFPIALELQVRAQRLTNTMLGQMVDRGCEITFSALTNVILALTSECSLVRECAMSTIQLILQLGAGNRLPKPTGVFLRCLLKRREELSIDGEQLSLVMFTMREGEKGRTIKPVLESFIERLNDPNTPAYIAAGIVDMLKLLDDPLVLVRPATKAVAILKAVNGDKARLTFDLYESKMLQILLGRYTADSTEQVMRNEICQRVITVALQCHKAMVVPGRRKHCTPAILMIEALADELFEALPKPYAKRVLLHIVEAAALSEHPETNSATAKLFKGCTIDAALAVDLVADMCNQSSSAGGQPTTKSLRNSIIAVAPCEQVLSTAVWKRGVTLLEHLQNKKKLENAHLLVPKLFECLKYCLDFEEQSVVEYVKQIVLSLLLHCIVKVEIVLEGSTDVTRVFGNVGTVFKVEQIVQCIRGSQNPQTHHHALLLLGHVARYVPEQVLHNMMEIFTFVGSSIVRQDDAYSFQIISKTIETIVPTIAGSESSSHEQVIPILKIFSDIILDVPEHRRIALYVKLLQTLGADEYLWVFLGVLIESDVLKGGRNAEQKSQRGKSRAEAELAQSELSKRMEVALLIAREFEPTVIIQTCTNLIDYLRELPMEPEKRKGGEEEELMEVDMSDAVIFNVKAHTNRQLRHFKYALVQFVGGLVSSVFVINKIAQLNEEETLGMKKYYQNLIVGILTYVKDVSKTIDRLKAESADEKIPLYWRAMLNYCYDILESTISLLSADTLIIVVHGLLKHRFLMVRRKVLELLNNKLQYKQDYFDERHHPGLLKLLDPLMQLVKHLHEEESVVGTAFERLVIVQLCYISLRHLSKILTQHATKQVQSVLADLVAELHGYKKNPNPQILASLILCIGELCSNLGPHSINFLPKFMPMVNKFLNAQLKSADPVDLLTSSIVLSMVKIVDSLSRFLSPYLRSMLVVLAKLYALVEQRNDARLANMLSRLALIWNNLAGTIAPRVMIPAIEESYHELVGEGELAAIGPLMKLLSTTFGKLKSSDFTAIRGELAELFLTVLQFRCNQSASDTFTLAGIDAAEAHVIRAFVVLILKLSESTFRPLFYQVFEWSIRESSSNDRAITFFNVCAHVAEALKSLFVLFASDLVTIAAKLLNATNRAKVGGEGHEEELHFAVESKNVTLLRYVLKTLYCIVLYDNQNFINAVRFDMLLGPITDQLENGLIINVAEVRTLVIDCLAQMAVAVMDDSLWRQLNYQVLLKTRNNEPEVRMFALEACTEIARKLGESYAPLLPETIPFLAELMEDDNEDVEKAVHHSCREIGRATGEDLQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKG1</accession>
    <name>A0A084VKG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Polyamine-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005854</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005854-RA">
        <property type="protein sequence ID" value="ASIC005854-PA"/>
        <property type="gene ID" value="ASIC005854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005854"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="14490" checksum="7A94075A84DD47B2" modified="2014-10-29" version="1">MIILTQRIFARVFRPRSLPTRGMHTQSKANTSDPNRGRLQSRIGSVAKTPQNPAARKGGDDKEQEIKEKYFHNRGKMIVPRTLPNVAQGDFPVQLESGAPTPSHVVAPIETVTESHISGKCFDGGKKEGSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKZ8</accession>
    <name>A0A084VKZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003489-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VPS13_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006035</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524965">
        <property type="protein sequence ID" value="KFB38642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKZ8"/>
    <dbReference type="STRING" id="74873.A0A084VKZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006035-RA">
        <property type="protein sequence ID" value="ASIC006035-PA"/>
        <property type="gene ID" value="ASIC006035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006035"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007964"/>
    <dbReference type="OMA" id="PSYAIEN"/>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006035-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="919" mass="102285" checksum="97875C06B3A7D752" modified="2014-10-29" version="1">MNLVLTSLMENKVRVFILASQFVVTNYSCIDLHCWSFALPANERLDQFKLNNSGPHSCCYSLPKNDVKCENPKGSVITMLNNVSQRKGKLKPSANFNHYLTVYRRREQGSDFSAPIYLNRPISRKSFSVPYGDRHVPLSLSIVAHQGQLHVSLFDDPCPSYAIENRTDFSMYVAQSDTVQPHKAATAVPETVEANFVWYQTVGSRQTVLYTPPGLDEQFPEPQETELALIFACVSGSAIRWSHPVKVDESKSIFLNIPLYGDLKLAVRVRNRTTELVIDYISQDQEFSAKDIRTRLSNPVRTDPETTGARGKHGGLNVSDGQTMPSGWSGAHPSEPVKRLHVQSFFRSLMVTLFNDQPNQACLKRDIISFNFERIGVRLERNPQHASKASLHCVNVQVDNELHSGGEYDFPVVLCSEDHEAKQRKLFATLPNHYRLEDHLDQLARSALCTFECDLSDEQWTNVDAVRVRINPIRAYIEDTYINVLLDYLMECLPTGMLYNEADEQRPPVRVRCEPGEALIPRTVVQQASYLAEPLKYRCIRIEPLAVLLSVHACMRLYIALDHSPLEFAAFERRSVRSLPIKFGNAVGMHYLSGAIFGGGWVIGSLEILGSPSGLARSVTSGLRDFVSLPVQGLFRGPWGFLVGVTQGSASLIRNITAGTVNSVTKLAQSVSRNLDRLTLDSEHVQRTDALRRRRPQGMTDGFTQGLTGLGISLLGAVGGLAHHPLQATNPFGVVTGMGKGIVGAFTKPISGAAELVALTGQGMLQSVGYNTLPTPKLSRKPLQRLEPISHKALWEPQAVCEGSLLFTVQATHALHGEYRLVLVAIYSKALVLYDVHECALLEVLDLKTVFFDTDDGADSTRLVIRIRPKLPPPPPTGYDQYPISSRTYDFVRDSTMQLPRLTGASLQPYYALYYGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL85</accession>
    <name>A0A084VL85_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006127-RA">
        <property type="protein sequence ID" value="ASIC006127-PA"/>
        <property type="gene ID" value="ASIC006127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006127"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004679"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783621" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16621" checksum="A862C644406B572F" modified="2014-10-29" version="1">MSLVLACVAIIHFLCLLAESVFAQHAIVCSCSPLRRQRCSLNARETAARGNGWDDRTSFAPLGVVIKPSSSEPDQRRRGCPAVLIFLSAARAEFSDPLAWRAIVSTTTCRLQMRPRKPFPLAWGDGSSLRVAPGWCNFRFSPTQRGTGGRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLD4</accession>
    <name>A0A084VLD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006187</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524973">
        <property type="protein sequence ID" value="KFB38778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006187-RA">
        <property type="protein sequence ID" value="ASIC006187-PA"/>
        <property type="gene ID" value="ASIC006187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006187"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006187-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11081" checksum="994592C1F475F516" modified="2014-10-29" version="1">MTATVNPVIKVPVPEKPLSTNSRTSFVQRHRAGTGGGHPSCILVSCLRTVAALGVAIRSTAANETIIGRFVHQRHQATTNITSESRLLHEFLFASFDGTTHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLD8</accession>
    <name>A0A084VLD8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP000974-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLD8"/>
    <dbReference type="STRING" id="74873.A0A084VLD8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006190-RA">
        <property type="protein sequence ID" value="ASIC006190-PA"/>
        <property type="gene ID" value="ASIC006190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006190"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018065"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022803"/>
    <dbReference type="OMA" id="VIYIETW"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF237">
        <property type="entry name" value="MIND-MELD, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="846"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="895"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1137" mass="121558" checksum="36C11B44BAE89360" modified="2014-10-29" version="1">MADRNGAGRYRRDVRETTKYIETALIIDKAMFQKRNGSTRTEVVHDAIQVANIADLYFRTLNTRVSVVYIETWQGQNQAQIDGGKDISKAISNFNDYTSRNLYKIDKDTTQLLTGETFAGGEVGMSVPETVCTPKAVGISVDMNPYEPHLLAGTMAHMIGHNIGMGHDDNRDECICRDWHGCIMSQSIVGLENVQPYKFSECSRLDYIDALRIGHGLCLLNKPNEVELRKNCGNGIVEDDEECDCGSALDCDKTDPCCDGITCKLKKESQCATGPCCDKCILKPPGVICRDAHNECDLPEYCNGESGQCPPDVHKKNGNPCGMNSTGFSTGYCFNGVCPTQATQCERIWGYSGTGADRVCYEQFNSKGSINGHCGKDSNGNYIKCEPENIQCGSLQCKDGERTPVEDCSEHLYSRAIISIRGTEYECKSITGTSTTSNTPPFGLVRDGTPCGDNLICVNQTCVSIFPYIDQTKCPTNHNNLECSGNGDCTNTNKCFCKFGWTGPDCSIQAHITTTYSSPVTSTTEAQIVMEKKTTRYANYHGSNTVFLVGVLMSVVGGVFITFALMALCYRKKTTRLKYDPPYVKKPMAKYVGGAATANHHSQDDISLEGSNKMMFGNQTTQFRDHKAIRRMTGSVSEDDPTHSGEEETVSFIDLPPNSLSGKQMPEKGILKKHGFGLVLGDGPKDKWSASAAAAAAANDDAHSDNLELLAQQESTIPSSGGQVVVGVGGVGGGGGVGGGGGVGGGVGGPGGLGGPGVIGGVLGGGVGGGGVGGVGIGVGGGVLGTVSDVERTMKSLNGYHEDILEALRSAAQAQRSSANTPSGSISEELLRKTLAECVTGAQISAASVHPQDPRDYKRSVSSRTGSRENVCEPQPHVLSDAGQTATLLHHHRQQQQQQQQQQQQHAGLLQQQQQQQQQQGLLGDEDDTPSVGPLRIRNLEDLIRQLEHHSSRHMSPSGSEDIRMSETEADRHYRVDSSAACSESSHGSNQQLAQSQKTATILPPYSSRCRPPRSDDEGRFSYGGVGGGAGGGGGVGGGGGGSGPGAGRYRHPASRHPGHQSHSPHSPHSFTHHTHHGHAHGHSAHAGHSSHHSSHTHLHQDEEGIYESADPVGHPHPHPHDRSVGLDQRDTNDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLT1</accession>
    <name>A0A084VLT1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00006247</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01014550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLT1"/>
    <dbReference type="SMR" id="A0A084VLT1"/>
    <dbReference type="STRING" id="74873.A0A084VLT1"/>
    <dbReference type="ESTHER" id="9dipt-a0a084vlt1">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC006247-RA">
        <property type="protein sequence ID" value="ASIC006247-PA"/>
        <property type="gene ID" value="ASIC006247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006247"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006877"/>
    <dbReference type="OMA" id="TFWGSEM"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001507">
        <property type="term" value="P:acetylcholine catabolic process in synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001445">
        <property type="entry name" value="Acylcholinesterase_insect"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF13">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00880">
        <property type="entry name" value="ACHEINSECT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="35"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006247-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="646" mass="72097" checksum="B1C12C67B39BAC56" modified="2014-10-29" version="1">MTSNHSVCRRSCANVLVLLLGATVICPAYGIIDRLVVQTSSGPIRGRSTMVQGREVHVFNGVPFAKPPVDGLRFKKPVPAEPWHGVLDATRLPPSCIQERYEYFPGFAGEEMWNPNTNVSEDCLYLNIWVPTKTRLRHGRGLNFGSNDYFQDDEDFQRQHQSKGGLAMLVWIYGGGFMSGTSTLDIYNAEILAAVGNVIVASMQYRVGAFGFLYLAPYINGYEEDAPGNMGLWDQALAIRWLKDNAKAFGGDPDLITLFGESAGGSSVSLHLMSPVTRGLSRRGILQSGTLNAPWSHMTAEKALHIAEGLIDDCNCNLTMLKDSPSTVMQCMRNVDAKTISVQQWNSYSGILGFPSAPTIDGVFMTADPMTMLREANLEGIDILVGSNRDEGTYFLLYDFIDYFEKDAATSLPRDKFLEIMNTIYNKASEPEREAIIFQYTGWESGNDGYQNQHQVGRAVGDHFFICPTNEFALGLTERGASVHYYFFTHRTSTSLWGEWMGVLHGDEVEYIFGQPMNASLQYRQRERDLSRRMVLSVSEFARTGNPALEGEHWPLYTRENPIYFIFNAEGEDDLRGEKYGRGPMATSCAFWNDFLPRLRAWSVPSKTPCNLVEAISQGSRTGATLLYLVAMLVLVLSLRQPALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMB5</accession>
    <name>A0A084VMB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001030-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006436</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMB5"/>
    <dbReference type="STRING" id="74873.A0A084VMB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006436-RA">
        <property type="protein sequence ID" value="ASIC006436-PA"/>
        <property type="gene ID" value="ASIC006436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006436"/>
    <dbReference type="OMA" id="YHAQQAT"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="229" mass="26815" checksum="52C896EE53C423B2" modified="2014-10-29" version="1">MIKDRLAELRSKSKYANCNLDDELDANARLSKSQEEIFENLAKVTVIRDKVEENLKESNNLCQRIYSTIKKLEVELEDDTRRTSVLFRIKHTQFIVIKDDYLSAYREHEEFVCYYEERIKDLMKLEARAMNYNITDDEAMEKLTSNQMSPFVGNILEETERERQKLRDIMTRHGQLQALEKSLMEIRDMFVRISSLVMEQVDTGEEGGGGEGEMSGLCQINCYFFFITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VME0</accession>
    <name>A0A084VME0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00006464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01014586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VME0"/>
    <dbReference type="STRING" id="74873.A0A084VME0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006464-RA">
        <property type="protein sequence ID" value="ASIC006464-PA"/>
        <property type="gene ID" value="ASIC006464"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006464"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004175"/>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006464-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="478" mass="53945" checksum="E304C5D58006817B" modified="2014-10-29" version="1">MQAPEFKDFAKEMVDYIANYLENIRDRRVLPTVQPGYLRPLIPDEAPQQPDKWEDVMADIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMLDWLGKMLDLPKEFLACSGGQGGGVIQGTASEATLVALLGAKAKTMKRVKEEHPDWDDHTIVSKLVGYTSNQSHSSVERAGLLGGVKLRGLKADENLKLRGETLEKAIKEDLDAGLIPFYVVATLGTTNTCAFDRLDEIGPVANRYNVWVHVDAAYAGSAFICPEYRYLMKGIETADSFNFNPHKWMLVNFDCSAMWLKEPYWIVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENIQAHIRRHCAFAKQFEALCVADERFEIFGEVQMGLACFKLKGSNELNEDLLRRINGRGNIHLVPSKVNDVYFLRMAVCSRFTEPADIDFSWKEVAASADELLAAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMH3</accession>
    <name>A0A084VMH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008711-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006503</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMH3"/>
    <dbReference type="STRING" id="74873.A0A084VMH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006503-RA">
        <property type="protein sequence ID" value="ASIC006503-PA"/>
        <property type="gene ID" value="ASIC006503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006503"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015511"/>
    <dbReference type="OMA" id="LADSSYM"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="130"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="42303" checksum="84DD33365073379C" modified="2014-10-29" version="1">MTTSSSTADTQQRKGHRRNESMYAMTGLYSEAQTDDSSADIPQDTESESLPMSVNTATTTTTTATCGTATATADTVIKCHSRQPSASVMMDREKPLPNVLLINDDYMRDCGILNCRPSAVQQFARIKVFVLLLSILVTLQQALSSGYINSVITTIEKRFEIPSSLSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIMIDNKTSDNICRLVSVREQDMGLGRLSNSLSNPPLTSHNLRGDNCLKSKSSTFGPVILFVIAQILLGGGGSPLFTLGTTYVDDHVRKESSSMYIGAMYSMAAFGPVLGFLLGAYLLSFHMDSFSGSDINIDPDDRRWVGMWWGGFLVCGILLIIVAIPFFSFPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ12</accession>
    <name>A0A084VQ12_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007516</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ12"/>
    <dbReference type="STRING" id="74873.A0A084VQ12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007516-RA">
        <property type="protein sequence ID" value="ASIC007516-PA"/>
        <property type="gene ID" value="ASIC007516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015498"/>
    <dbReference type="OMA" id="HVCHIVV"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="979" mass="110866" checksum="E8067817403BEA64" modified="2014-10-29" version="1">MKPFESFVFPTIPPELREKFLDDEKQMVVVGILGKSFEPHCSKLLNFDLLHTHPGVGDETGTDVKLQRNTLFLHFDATFDNFVLMQLAEQMLSKQPDGNPAHFIEFNSAIRTRFARVLLLALQVCHILVLVEQSVSFDMSYLSIFKSLKIIREKYVLKFLPKLLRNADVGSFMGKECRLCSPRLLFMFNLPEGSETHTPDDLEMLETKVEDYINKIFRNEFIITNNSAMSLFSVSKNKQFVFYNDLKSHRLDPLEESIDLLSSYLSKQQKTSTGTLPEQDEQAILDSVRPYDFFGYPLKYHFNMDVDVFDDDDDERSILGLINDHVVEGLETGFDETGVCGRQKSKIHFALPSTYAWFETFKYMYELFIVNPNTPYYDAYDTDYKAFIENFHDIVDIDEQFFGEICEHGLELAMMNYKDMLPPHYSFSFHETKYQAALNLFMDYARGPELKPSIAKLKEYCDSIWQSGKQQCEYPSLRGNPCVLGKHKPIDASEHSSGVIYVSACNCGRTQGHREDPYTIRQANYEFYQIIAKSCSNCNRLDRVQFPIFEPSISDFRAAEFINKNFSNLMSFDSTGRTASDMGPNFRTANENSIFLSGSQKSQNSSASLSFNIGSEGEEDELDGNLAKKIGDRRNRQQVAEPNDQEQFNTNRDEFGEDDEEVDDYNGSDEQIMNINARMKEIVIKVGGTSKATGSQSNDATLATGLSRQPSTTEYLPGMLHAASPAGLLPRFPSWSLVCLGSSSIYTHNTGLPEHVQSGFLSGSNFLLPWDVSVRLEHAQCWAASYEKIRNRKKGNQHSSKGFEHNNTFTLKIFIGVEYECLRGHRFIMNAPDSILRSATEITRDSGSKVVFNDMPIYFPCPCRNTINNTAQLMRVHIITPKAPVNVIIDPKVKIFQNNMQNSVTFTSGMAAPIKLPQSSYWILRLPFVYEGDSGPLAAPTNVNPSSAIMHGALMAGMFGIRENELTEETAGGLSNHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ88</accession>
    <name>A0A084VQ88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000629-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007667</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007667-RA">
        <property type="protein sequence ID" value="ASIC007667-PA"/>
        <property type="gene ID" value="ASIC007667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007667"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006376"/>
    <dbReference type="OMA" id="CQVRDQR"/>
    <dbReference type="OrthoDB" id="4794873at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF4">
        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="742" mass="84599" checksum="8CE43549E415D331" modified="2014-10-29" version="1">MGMVNASEHAASTAGYIKSLNSKVFSINVPFDPAYSKRVSAQCRLQSAQFFRAYAASSLWALRMHDSSAKVGQGILNGNINQYGDFDQCLNIQQTLPGVDGEKIQGRYCMAEVQPTIKPNTLVLKHIFDLVQAHGMLKSNLNDPGHRVPRFSTVHWALCVPAGCTAEDVQQSLSEFLQHYITDTGIQTEVKVHPALCQTKHAIWREYFTDRTWLVWYGFALYAALVLASTLYDLKSHDKGKANACAKLVRNSSRPQSLSPSHSFAVEWFTVFSLIKNTRSILSFREERNDIACVHGIRFLNALLLLIAHKSMALFFNPYVNRTEMSEILGQPWTVIGRAAAIFTDPFIMFSGFLTTFSFVERLAKGQRVRLHQEYVGRLLRIVPPLGALILFCTFVLPFLGSGPLWNLVVTNHGDICKRYWWRNMLFIHNYFGFKNMCLTHTHHVGIDTELFFVAPLFIYLVWRWPRRGLLALLALATITTVQRFYVTYNLRLANYVYFGTSVKQLFETADFMYTLPYYRVTVYIMGVILGYACSQCKTMKLTEKQIKIGWYVSTLSIAVAFFGPAPMGSIHYVYDPLHAASYAAFSPIAWCLFFAWTVFTAHLGYRNKLIDFFSWRGFRITTRISYAVYLTQFPIFFYNVGRTRAPQYFEFWPAVIFNTNEYAVVFLASFLLTVLFETPFINIKKMLFRKGNKSQQQPVDVAKVDDGTGKVPKDSTWDNDGPDRATTVDENENSRPSSGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQE7</accession>
    <name>A0A084VQE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007564</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007564-RA">
        <property type="protein sequence ID" value="ASIC007564-PA"/>
        <property type="gene ID" value="ASIC007564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007564"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007564-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6590" checksum="F031CBCD0D6F4D88" modified="2014-10-29" version="1">MVPDIVSRRYRVQIASFEGVFPNRTPGHRGPLHSTFPIHPTALYLDHSQSRVSWVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQI7</accession>
    <name>A0A084VQI7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00007608</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01015217">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQI7"/>
    <dbReference type="STRING" id="74873.A0A084VQI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007608-RA">
        <property type="protein sequence ID" value="ASIC007608-PA"/>
        <property type="gene ID" value="ASIC007608"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS020895"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783832" description="GDP-fucose protein O-fucosyltransferase 2" evidence="19">
        <location>
            <begin position="30"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB40231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="457" mass="53874" checksum="ED803E6B79317554" modified="2014-10-29" version="1">MRLHNIEFRCLSLLFNALALLTVSHIVHTTHIRKICEKRDIFFEAFSCPRERPGKWDHEPITYLLYDVNPGEGFNLRRDVYIRMAVFLQFLRTQPGYRRSRLVLPPWSNLVHWRSHNIEQTQLPWSHFFDLPSMKAYTDVIDTPEFLAAYETLHGQGAAVVLDEVYKLKHFDNMFENGVFVDKFEEHVCPKSDSGTLPFLGYTNFATKEFTCLHFQGSAMLLHKLLETYKRKGQSVRYVLVLNAEIVLHDLWGNVDYWEARRSMRFAHSLVEVADRFRWDYLNSSDEQDRTVRPANWRDASHRRRAKGGEYICAHLRRADFLYGRDKTTPTIQSAALQIRAKLLELGLKTVFIASDCSRTEFYNLKNYLKRFRVVRFAPENYEQRATLKDGGIAIVDQIICSHARYFIGTYESTFTYRIYEEREIIGFPKDLTFNTFCKSEKEMNCEKNTVWPIVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQN9</accession>
    <name>A0A084VQN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007314-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007767</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB40283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007767-RA">
        <property type="protein sequence ID" value="ASIC007767-PA"/>
        <property type="gene ID" value="ASIC007767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009225"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6778" checksum="579DC7A27AD89F79" modified="2014-10-29" version="1">MSSPFPFPKTVVALYVGYTLVILYRVFDSRCKEDEEDIEQVHRPVKFYFGDDPDDTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQP9</accession>
    <name>A0A084VQP9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007306-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015290">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQP9"/>
    <dbReference type="STRING" id="74873.A0A084VQP9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007778-RA">
        <property type="protein sequence ID" value="ASIC007778-PA"/>
        <property type="gene ID" value="ASIC007778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007778"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008067"/>
    <dbReference type="OMA" id="ATCTQMT"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007778-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="21901" checksum="77E466C8B0E9B482" modified="2014-10-29" version="1">MDSTLAVQQYIQQMIKKDPSNVDQILTMPDGQDEGVWKYEHLRQFCMELNGLAVRLQTQCFPATCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRVYRIFSHAYFHHRRIFNEFEEETSLCLRFTNFVTKYTLMSKENLIVPIPECELTPGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQT7</accession>
    <name>A0A084VQT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007273-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007821</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015320">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007821-RA">
        <property type="protein sequence ID" value="ASIC007821-PA"/>
        <property type="gene ID" value="ASIC007821"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007821"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009300"/>
    <dbReference type="OMA" id="QYCFYKY"/>
    <dbReference type="OrthoDB" id="7740274at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783929" evidence="1">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007821-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="507" mass="54325" checksum="0B42930A51A50E5E" modified="2014-10-29" version="1">MEKMNQLPIVTFCVLALVQYTSAEPRPEFALTATVPGTSRVSVAASAADTAIADINVSVQNYVITSELQLLTDVATIVADIANQYQPLAEAITDAITALASDTSGDIDGAFAVALGAVADAISFADNTLPGLEAPLVPLVGNALPDKFLDSFQHIGKALEKLETSLTELKAAANSAVAEAGSSGLTATIVSRTVTRALVGDLVYALNLLKATVPLLEYVVSSTMENIGLADAFMLELDQKVDDTIGESSTLQLEVETITQPLGDYIANTLNTIDTDLGTLATTFAGLTNLASAAELGAVLDNFKDNLVLLSMADPSIANVLAELKKALTDAYDVVDPLYFIYESPLVNALMTTLVGNGNYAQYCFYKYKDYFFLLLDWIAYAASECIQEEAPRLEYYQDTVKLMLDILFYDFEDIADDLEVCNKINDATNLQECTSKFAEIYDALEGSFGNKITLGYQSLQHEIAASGNRLKICISLSQSALSNDEVPKLLEDINSCANDGPTGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR30</accession>
    <name>A0A084VR30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007903</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525013">
        <property type="protein sequence ID" value="KFB40424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR30"/>
    <dbReference type="STRING" id="74873.A0A084VR30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007903-RA">
        <property type="protein sequence ID" value="ASIC007903-PA"/>
        <property type="gene ID" value="ASIC007903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007903"/>
    <dbReference type="OMA" id="VWKGLYR"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6473" checksum="E81150BFA4D7D20F" modified="2014-10-29" version="1">MGMWKTLSIIYNENGIIKGLYRGMSINYLRAIPMVAVSFSTYEVLKQALKLDTGMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR35</accession>
    <name>A0A084VR35_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 16">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00007908</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 16"/>
    <dbReference type="EMBL" id="ATLV01015446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525013">
        <property type="protein sequence ID" value="KFB40429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR35"/>
    <dbReference type="STRING" id="74873.A0A084VR35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007908-RA">
        <property type="protein sequence ID" value="ASIC007908-PA"/>
        <property type="gene ID" value="ASIC007908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007908"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010928"/>
    <dbReference type="OMA" id="CEYDHEA"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF85">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 14 16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759873" description="Alkaline phosphatase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="911"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="952"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="953"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1032"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB40429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121312" checksum="CA1460330B1BC6F3" modified="2014-10-29" version="1">MFSVVHFSALVLSLTLVLAVTHVDSASSRRTDVDQQHPRSDSRALNSVPEYDAREEVSEYWHDVAQRTLAEHTAQPNNARKAKNAIFFIGDGLSLPTVAATRMYMGNENVSLSFEQFPYFGLAKTYCVNRQVADSACTATAYLSGVKINYAMLNVAASVRRTTCEYDHEATEFKGLLKWAQDAGKVTGLVTNTRITHATPAGAYASSADRDWEDDTEVNADCASTPDERKPVDIATQLIHGEIGKKLKVILGCGRRMFLPKGTPDEDGINGTRSDGVNLIEQWKQVHADLGRAEYVSDKRSLLEAAKSNQVDYLLGLFGSSHCLYNLEIDDQQLPVEERKPKLSEMVEAALQMLEGSDQGYVLFVEGGLIDMAHHSNRARLSLEETNEFHKAIELARTRTSIDDTLIVVSSDHSHTLMYNGYPTRGSDVLGIGDVSDVDKLPYTTLSYANGDGFSETYASGNPSNRIDISNLDFKNYRQRYLATVPLSSETHGGEDVGIYASGPSAHLFVGSLEQNVIPMLIAYATNIGAELGWDPEPNPTDDDGDASTLSLSMMVPIGLSLASRERDQHFRQRKEDKLQSDTKKPKSQGPPVQGFDDQELETDYWLEQGQKTLAEKLATSHNTNHAKNVIFFIGDGLSAQTVAATRMYLGNEANSLSFEHFKDLGSVRTYCVNRQVSDSSCTASAYLSGVKINYGMVNIAASVPRYACEYDRNASDFDGLLKWAQEAGKSTGIITTTKITHATPAGAYANSANRYWENDVEVASSDCDPERVEDIAEQLIGNDVARHFNVVLGGGRGNLLPKDTIDEEGKPGYREDGKNLIDEWKRTHATMGKSEYVWNREQLLAVDVSSTDYLLGLFENGHMKYNLEVQASSEATRLEPTLEEMTETAIKLLRKNQNGYVLFVEGGLIDVAHHETWARLALDETAEYSKAIDTARKITSEEDTLIVVSSDHSHTMTYNGYPLRGNDILGLGDESDEDQLPFTTLSYANGLSYYTTYTEQNHAVREDVSKYDYTDPKQLYMSMVPMDAETHGGDDVAVWVSGPMSHLFRGVYEQNTIPYIIAYIANIGDYYTGASSAPVFLSLPLLVVSILLAAMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRC9</accession>
    <name>A0A084VRC9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008017</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VRC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008017-RA">
        <property type="protein sequence ID" value="ASIC008017-PA"/>
        <property type="gene ID" value="ASIC008017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008017"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017062"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000095">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="538"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="687"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="834"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1275"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1424"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1676" mass="191404" checksum="F8EB1524589415AC" modified="2014-10-29" version="1">MSQQLPIRFQEHLQLTNININPSSISFTNLTMESDKFICVREKVGETAQVVIIDMNDAQNPIRRPISADSAIMNPASKVIALKAQKTLQIFNIEMKSKMKAHTMTEEVVFWKWITLNTLSLVTETSVYHWSMEGDSTPIKMFERHSSLNGCQIINYRTDPKQAWLLLVGISAQQNRVIGAMQLYSVERKVSQAIEGHAASFATFKMEENKELSTLFCFAVRSQTAAKLHIIEVGTPPAGNVAFTKKAVDVFFPPEAQSDFPVAMQVSPRYDVIYLITKYGYIHMYDIETATCIYMNRISGDTIFVTAPHESSGGIIGVNRKGQVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLSGAEDLFVRKFNHLFTNGQYAEAAKVAAIAPKGILRTPQTIQKFQQVPAQPGTSSPPLLQYFGILLDQGKLNKYESLELCRPVLAQGRKQLCEKWLKEEKLECSEELGDLVKPSDPTLALSIYLRSNVPNKVIQCFAETGQFQKIVLYAKKVNYSPDYVFLLRSVMRTNPEQGSGFASMLVADEEPLADINQIVDIFMEQNMVQQCTAFLLDALKNNRPAEGALQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTQLLNGDWLVGFFGTLSVEDSLECLKAMLTANIRQNLQICVQIATKYHEQLTTKALIDLFEGFKSYEGLFYFLGSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNAERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNSLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERFLKENQFYDSRVVGRYCEKRDPHLACVAYERGQCDRELIAVCNENSLFKSEARYLVRRRDAELWAEVLSEANPYKRQLIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIVLDSSVFSDHRNLQNLLILTAIKADRSRVMDYINRLDNYDAPDIANIAINNELYEEAFAIFKKFDVNTSAIQVLIEQVNNLERANEFAERCNEPAVWSQLARAQLQQGLVKEAIDSYIKADDPSAYMDVVETASRNDSWEDLVRYLQMARKKARESYIESELIYAYARTGRLADLEEFVSGPNHADIQKIGDRCFTDRMYEAAKLLYNNVSNFARLAITLVHLREFQGAVDGARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQDRGYFEELIGLLEAALGLERAHMGMFTELAILYSKYKPAKMREHLELFWSRVNIPKVLRAAEQAHLWSELVFLYDKYEEYDNAVLAMMAHPSEAWREGHFKDIITKVANIELYYKAIQFYLDYKPLLLNDMLLVLAPRMDHTRAVSFFTKQGHLQLVKTYLRSVQSLNNKAINEALNGLLIDEEDYQGLRTSIDAFDNFDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDRLFKDAMEYAAESHQGELAEELLGWFLERGAYDCFAACLFQCYDLLRPDVILELAWRHNIMDFAMPYIIQVTREYTSKVDKLEASDAERQKEGDSTEHKSIIMPEPQLMLTAGPGIGMPQYAPQYAGAYVAPQPNMTPYQYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRZ6</accession>
    <name>A0A084VRZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008166-RA">
        <property type="protein sequence ID" value="ASIC008166-PA"/>
        <property type="gene ID" value="ASIC008166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008166"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="259" mass="28366" checksum="6726C1122966A91A" modified="2014-10-29" version="1">MAHYGELIAIRNRQIIYLGVTNGTDKAINREGRKYKQWQLCSTYDPLGNVDPRKTRRSTADSSGDHYSQPQHPGKSRPRDTCSAGGSPVLNYRRSEIANRPQNGPVGFDRSDSRPSSDVPASFAATPPAVCAVSNSSCIHPTHDVPRNPAPSVDNGIPRNVLTLTVSSITRFGSGQLLGGRSSTSKPLVAHASSMVSFELQQYTLPLSGAKRWQASIHRFIDGFETLETLIFPNRGWKAGRLGVWYNGNPPRNARIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSB1</accession>
    <name>A0A084VSB1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008379</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015906">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525041">
        <property type="protein sequence ID" value="KFB40855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSB1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008379-RA">
        <property type="protein sequence ID" value="ASIC008379-PA"/>
        <property type="gene ID" value="ASIC008379"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008379"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008379-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11230" checksum="4609DDD2144F284A" modified="2014-10-29" version="1">MQDFRHPAHHASSVEEDRKLSRNALHHVTDDAGPYTEWVKLRLDRFPPRLPSNAHHIQLCLCGSNLGQVFPQEVERRDQQSIVDSGPKPSCERVATLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT34</accession>
    <name>A0A084VT34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008589</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008589-RA">
        <property type="protein sequence ID" value="ASIC008589-PA"/>
        <property type="gene ID" value="ASIC008589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008589"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6138" checksum="B05866C1079F641F" modified="2014-10-29" version="1">MLLRCSTLWFALRSSVRFADTDTFHGLDDRGRASGSWGTVSDVILAAPMPPAAALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTK5</accession>
    <name>A0A084VTK5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ankyrin repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008893</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTK5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008893-RA">
        <property type="protein sequence ID" value="ASIC008893-PA"/>
        <property type="gene ID" value="ASIC008893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008893"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11953" checksum="151C5020CFBF1CAD" modified="2014-10-29" version="1">MGSSLQPRTATSIFGSHRQEHRDDGSPGIKRCSRTFHPSRTRWIQTRELHPGRDPDPAGGQQLLGTILCDRIAPMQPSETDFPRYANGKNGRERDEKAGDGGLTDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU04</accession>
    <name>A0A084VU04_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Bifunctional protein CysNC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009047</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525097">
        <property type="protein sequence ID" value="KFB41448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009047-RA">
        <property type="protein sequence ID" value="ASIC009047-PA"/>
        <property type="gene ID" value="ASIC009047"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009047"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009047-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10447" checksum="8EC14A183F518263" modified="2014-10-29" version="1">MSPARQGYPVLSHVFALILEPLCSFLKTRAFVDPGAAPGATGYKGDCIVSLVYDRPTKNNDYDEDDDNDDLYLRRRQSSVTGSLSSPLTDRPPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUC9</accession>
    <name>A0A084VUC9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="13">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00009174</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01016720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUC9"/>
    <dbReference type="STRING" id="74873.A0A084VUC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009174-RA">
        <property type="protein sequence ID" value="ASIC009174-PA"/>
        <property type="gene ID" value="ASIC009174"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009174"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001462"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783949" description="CLIP domain-containing serine protease" evidence="14">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="16">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="141"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009174-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="401" mass="44139" checksum="96B1B45FC7561809" modified="2014-10-29" version="1">MRLRPALAALLIVTNAWSVLAQSDPACTTPANKNGFCVALERCRNIYNLLNGGTPTRGHLNYIKRAACTLPNVERSICCQPEEVNHLVTTTTSTTTNAPSGTMLLLSTPPIKSVPLAADDTVVTWDMFQMEQCGLSTYDRIAGGNKTRPYEFPWMVVLRYQTSSGLEDKCGGSLINTRYVLTAAHCVRTSSSSRLVKVRLGEHDKTTDEDCITYQDGEVECAPPAYDVDIEEMIIPKDYNRPIKFRHDIALIRMAEDIKYSDSVKPICLPVDESVRKQLLPKYIITGWGTTEEQTVSPLLLQAFVHHVTIPECQQKMNDNFLAVTLAEPWQMCARGDNLTDSCQGDSGGPLAFTVSIAGSAKMVQYGVVSAGVRSCGKESVPGIYTSVPAYMKWIVANMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUE7</accession>
    <name>A0A084VUE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP005257-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009194</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016730">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUE7"/>
    <dbReference type="STRING" id="74873.A0A084VUE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009194-RA">
        <property type="protein sequence ID" value="ASIC009194-PA"/>
        <property type="gene ID" value="ASIC009194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009194"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020455"/>
    <dbReference type="OMA" id="ELICMTY"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20817">
        <property type="entry name" value="C1_Stac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000056">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000071">
        <property type="entry name" value="Uncharacterized protein, isoform U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="792"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="895"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="898"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115360" checksum="D30323DAB11DA567" modified="2014-10-29" version="1">MYVIFPADELISLTYGLAVPRVPPRPTLDNLREPLVPTGSRPSSTTTTTTTSAPTKHTPSKSTSSSKAPSSSAKSSAAQPGGSKKAPQKDASTRAGKPPTAQTTPPVATPKGSTRSQQQQQQDSVESYELDGPSGTQTLADTSELAAFVDDGGPRNGTYSAATAGTATANASPLGSPKGSGRGGPGREQGPGAKSKSKLQLKLGRLRPHSSIDQCETASRVREDLHIHVSNPVFTRDNLRQRNFDAFFESGEQVYSLEVREKPPARTLQDGTLGAPGGSDPGLADESGLRPAYSTGGGGGGYDSARPASLGFFRKPKSPLSVRSKSAEHEFSDVETSQKGDDSMSTSGGGVLKDLGHPGLNEALKSHNSVTFKLVKTVSDFSETLAQLYEQHAEALQVLVSNYRKRNSELRKERPACQSNLFAAWETLLQEIEADSQATIDVASTLSRQVARPLLERSFYRKVQSRKVFTHRESFDTIISKTEEKLSKCRIEYKQCYIAHRQSPTQHTLTQYIDSHNAYVQQLHATNAMLEAYHCETLPQLMQELEEIYNDLCGIVTEAVLQGAEAIAAKAAEQAKRYDGLAVQCKNVSPALDLGYFVRTLPLPPNVQRIPRKAFAPPQPANAPTNEPGAEDLPDYGMDPMVPVFKDELVVDRGATIQVRPSLEALRRESQELEIQIKQLQDSVDALVRTQIRGIESQLYNKANEIQEDISMKKFDVRAKQIHLAAVRAQKELFLGRIEPGSPRGERKMSSSSSSSMKTKWLKAFRSLKPAGSANDRKSGNGAQIRFDGTDNHNLQEYTYKKITPCDVCSQVLRGHTRQGLRCRICKVNVHADCASQLPKCQVKQKLLRRQKSTSEIENRAAAEVEEEKPTDVDQIYQVLKQAREISSGKLVVEASKGPAAPGTTQPAGPNQPAAPNPPLDIPVVKVPEYPDRAPWRGPVKSQGPNYPHQKQGLSAPVTTDMSSSDIRVPITNPHTHQVAAIDSGARRRLFAGFRPMSGFGVLRLRSAQHRSISLPETEEDDIMISTRPFGQPLCFVVEEPPPEEQQSGKKDGKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUF7</accession>
    <name>A0A084VUF7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009211</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525110">
        <property type="protein sequence ID" value="KFB41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009211-RA">
        <property type="protein sequence ID" value="ASIC009211-PA"/>
        <property type="gene ID" value="ASIC009211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009211"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="233" mass="25478" checksum="48822E13255EABE7" modified="2014-10-29" version="1">MIVTRSFRVPPGWNSCGAAKIQARGRRSCVRPSWGRYLRRHALGGWPRLPCSRSVIPGAHASFVGQVVLQFEFAVAHVERDGCKTVCEAADHCSGVCHTIPGRSGSERDGNGKTHKKKPPIALRQTGPPPSTTVPRKANSDSTELEPVLQRRASERERHRASKPAAKQSAWVSAEPTRLAAQQFSIGLGGESTQFYFSLRLSSSSSQWRLLLLLLLVLLSACHLHAGCLISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUM5</accession>
    <name>A0A084VUM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP010459-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009295</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUM5"/>
    <dbReference type="STRING" id="74873.A0A084VUM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009295-RA">
        <property type="protein sequence ID" value="ASIC009295-PA"/>
        <property type="gene ID" value="ASIC009295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009295"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020021"/>
    <dbReference type="OMA" id="TPNKFWA"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB41669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="485" mass="54029" checksum="E8D2939AC3CC0A77" modified="2014-10-29" version="1">MTDKGLIKRMSQSSKSRSSFPVATPAAGPSVAPNAVGVVPGSRLPPVRQSLVSSVPSPGSPEQSVLVPHVKTSENAKVLPKYTAALQNSTEELIPAEDLDTIQLELELLLSTVALRSRVLKAELETIDKADERRERKGKHLDRAPSSPGKRKRLEEKQKFRESAGKLLGQQLKISKMKHSSTLVPPSPAPSQHTDDSMDAVPFLPQNHHLQHLNSDAKPIVPKNDTPNKFWLSVEPYCMPISHEDLKLLDDLLEEYSGPLIPPIPELGPHYSTQWAADDIKEEQDGVANSAASKSNGEGITGPLTQRLVSALMEENLHPDCTSTSNENSNSSSDVTHSNNARSAVALLKNGISIERRLRKELIEQGILDADDMPKSQQDDEILSEINRVRTELAVIAEYNSNEIRKLQSMAKDEMKRIEVKRKLDRVDQEIMEVYQKVIGARQKRRPLTKQERDEVYRLTEEQKRLSDQLELMPVHGPFGRTQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV92</accession>
    <name>A0A084VV92_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00009732</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01017163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VV92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009732-RA">
        <property type="protein sequence ID" value="ASIC009732-PA"/>
        <property type="gene ID" value="ASIC009732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009732"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010511"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019956"/>
    <dbReference type="OMA" id="CEILHET"/>
    <dbReference type="OrthoDB" id="6147412at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000002">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF26">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="339"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="1015"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1369"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1436"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1532"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1576"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1674"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1713"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1393"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1403"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1454"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1641"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1677"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1713"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1781"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1885"/>
            <end position="1895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB41886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1986" mass="218899" checksum="4FC625DEEC35C09E" modified="2014-10-29" version="1">MQTGSVEQQAGKRKSSSNWWSRAPGSGSTSSSHPATLDDSGRSANAADGLNQCRPNRSTNRPANMDHAVHAARGRPWNKLRFENNELESLYQRYTLKLQRFSVTGVVALVVILCGVMGGLSLGFNQAPTLHNVFNSFLCALFAVLLGSLQFRLIRDSHLPYLCYGILFFTAAFCFISMPTVGIVFPVDTREVMAEGVWQIVFVIFLAYAMMPLQIWEASLFGLILPSIHVGLTSYNMYTGNFQYLAFQQLAANIVIFFGVNVAGFVVNVMMERAQRRAFLDTRNCIAARLEMEDENEKLERLLLSVLPQHVAMEMKNDILSPVEGQFHKIYIQKHENVSILFADIVGFTVLASQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGIPDPRADHARCAVEMGLDMIDAIASVVEQTDVILNMRVGIHSGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDALGGEYEVEAGHGETRDSYLRDNQIDTYFIVPPAHRRKPLMLNTLGVRSALGAANRRKLSFRNVSNVVVQLLHTIKYSVPVPFSHMATGGGGSPYPSTSGGCSSSGGGPGSSGNAAGGGSGGGGAGGGGGGLFLDKNARKVLHLQRILHASPYPVALAKSGVGGGGGEHASSSGSNTRTVGSRASVYESELSASKNKVTDKFKRPFKKRHSSVYHQPTNRVNKFLSQAIEARSVDREKSVHVKRISLQFREKEKERQYHQDFDLGFTTAMGCSLLLLILSAGLQISVLPRTLILLLLFLTAFVWISAILMLLLAVRLKWIFWDLSQSFSLRLAITIFTIVLLYSVGQVNVFTCLSDHPCTTNFTTKSVHSAEPHRKCALPQYIALSAAYSFLSVSIFLRLPILIKTVLVTLMGLVYCLFIELSHANIFDCYDQRVESAIPLHTISVARILIFMIAILAHGRQVEWTARLDFLWQLQASQEKKEMSVLQQSNRRILYNLLPSHVAAHFLDNQFTRSNMATMRQDLYHQSYSKVGVIFCSVPNFHEFYTELDGSNQGVECLRLLNEIIADFDELLCEERFHAIDKIKTVGSTYMAAVGLIPEYKMLPSEPGSTRRLMTALIDFVKAMRVTLKNINENSYNNFMLRVGVNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGIPGYTQVTQEVVESLQGSHFEFRCRGQIKVKGKGDMVTYFLCEQNESLFNGAGAQFSGLGTNGSGMHGIGAVPQTQPTLQTGAGPTTMVGSVAAASITSGAGTGTGSLQHSYGETAHHIVLHHHHHQDGQQGPPGMMAQAQSLHAKQRANGNEPLLGATAGGGVIGNAVIKPIQQIQQIPKYEPPRYATGSSMFPLAGVGGDGQNYGGYLMSHNAPQQQSPQLAVRHNHHQQQQQQQAQHQHQHQQQYHHNHHSSQRQPVGLLKQYIKPLPKLPPEFDECRELSSTDDLSSRPHSPSVSSSDESYSKTTEGEDFDGHSPLPVGAVFANVNNVNNPLQYLYPCDIQVDPTASPKLSPIDFSNMRDFEVTSTTAETKSSSAHNKGESCNSFEYHEKDAPPSAAAAVFPKSPFERELQRRMNESQSRPVLAQAGGGGAADGGERAVTHSSSGEVPSRDSYPNAHTRHLEQQQLQQVGGAGDAFERQDGTPDRATKNVSSILSAKHPGTLEAIKEATRNKNPSESSHMQTSDTESCEIIHDYRMTGADRFNELQIRQQQQQQQSYLQLQQQQHPQHNQMQPEQQQQQQRHRHHKYNPSKYETSYNIEGAEEMRLASGHRYRAEEEDDEEEEEEEEEDDMGDEDEVEDEYEGEHEDEDEEENARRPVQRPPGRREQRRNSAEVSAATRNYITDELKYGAGHAGPAERGENSASQPNSGHNSHHNHQSLDSNPVESQSEWSDDDCREEATGGAESTGYITDEPGLENISLLNEAGLTDAEGALSDVNSLYNAPDVDDTSISSRASSRLLSLDSLSGLYDCDIAIGGTTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWP5</accession>
    <name>A0A084VWP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001800-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010082</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
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            <begin position="155"/>
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        </location>
    </feature>
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            <end position="110"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="458" mass="50339" checksum="A24FEFBE4708C8BB" modified="2014-10-29" version="1">MGDHGPDMNTLETVVPAVLGLTAAAILAVTACFCARRFRRQNKKTNHEASSLPFQPPRPPKAVRSPSGQPPQYLKKSPSPTSVKPLPGHLPAQSPTEQATVVTTTTTSVVPPTKYTEENELIPKNAQLEPKSPDVSEMGDPVTAELNGDGTEHGKLGTIVFKLRFLADRSALVVSVVRCRGLPGKNHNSEAAELSPMPAGTLCNGSANGKQTATDPYVKLQLLPDKQHKVKTRVLRNTRNPVYDEDFTFYGLTLTELAGMSLHFVVLSFDRYSRDDVIGEVVCPLSGIDLQQIENQQVALSREIQPRSLKIRAQGRGELLISLCWQPAAARLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPTTEGAGASLDGVSLELMLLDWDRVTKNEVIGRLELGGPRSNGSALNHWKEVCNSPRRQIADWHKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWV3</accession>
    <name>A0A084VWV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010148</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC010148-RA">
        <property type="protein sequence ID" value="ASIC010148-PA"/>
        <property type="gene ID" value="ASIC010148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010148"/>
    <dbReference type="OMA" id="TSHATIQ"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784044" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7207" checksum="923D8AF7DA3445FD" modified="2014-10-29" version="1">MAFKFVLLATLVAAASAGLLPAAHHGSIATSHSTIQHHAAPAVHHVGAIHAARLCTNTSPPSSRPSLSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX14</accession>
    <name>A0A084VX14_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nitrogenase iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010215</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX14"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010215-RA">
        <property type="protein sequence ID" value="ASIC010215-PA"/>
        <property type="gene ID" value="ASIC010215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010215"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010215-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7899" checksum="2DF91110CD2AC0C9" modified="2014-10-29" version="1">MPENGFKFIAYGCHRVQTPSTNWCRNGKYAPNAQPQDRMPPPSTVFRMTDGLRAKHPLAADVVGPASMLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX27</accession>
    <name>A0A084VX27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010229</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX27"/>
    <dbReference type="STRING" id="74873.A0A084VX27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010229-RA">
        <property type="protein sequence ID" value="ASIC010229-PA"/>
        <property type="gene ID" value="ASIC010229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010229"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009694"/>
    <dbReference type="OMA" id="IYDYYGV"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF150">
        <property type="entry name" value="FI17861P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
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            <end position="369"/>
        </location>
    </feature>
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        <location>
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            <end position="408"/>
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    </feature>
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        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB42521.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="483" mass="52412" checksum="88AAFD9B77F7C7DB" modified="2014-10-29" version="1">MGKSTNPEAEEPVSAQGDAIQLQESNGLAGFVNVSFDADSVPDQLTVKSAELDRSEAAPHGGGGHGLQADHPTSYLETIMHIFKGNVGPGLYAMGDAFRNGGLLLSPILTIFLGIISVHSEHILINCAGKMQSQLKLAAMPDFAETVGLCFAHGHEPLRRWSRTLHAAVNFFICVTQLGLCCVYFVFISSNMKQIYDYYGVVFDVHWHMLIILLPTMLPALITNLKYLAWCMTIGNSCMVLGIGITYYYAVQDLPPLVGSRPLVGSWHTLPLYFGTAIFAFEGIALVLPLKNAMQRPRDFSRPLGVLNLGMTVVTLLFTTTGFLGYLKWGDTVQGSLTLNLPEGDLLAQAVKVMISTGILFGYALQFFIAIQIMLPAVRRRFDPDQRHPVRLELLFRVAMVLLTFLIAEGVPNLGAFISLIGALCSTALALIFPPVIELTLLAAPGGRLPGVVWAKNGLILLIASIGVVTGTYESMLALIKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYR3</accession>
    <name>A0A084VYR3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">D-ribose transporter ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010903</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018409">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525233">
        <property type="protein sequence ID" value="KFB43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010903-RA">
        <property type="protein sequence ID" value="ASIC010903-PA"/>
        <property type="gene ID" value="ASIC010903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010903"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6303" checksum="1A3653E5688EE75A" modified="2014-10-29" version="1">MILQQTLIRLRKLVQFLLKTVLAGHHPPVQDHQTVNALRMDYSLLHKQLSFIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W047</accession>
    <name>A0A084W047_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011528</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W047"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011528-RA">
        <property type="protein sequence ID" value="ASIC011528-PA"/>
        <property type="gene ID" value="ASIC011528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011528"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8545" checksum="5B710C575ED07EF7" modified="2014-10-29" version="1">MASLRAFSSGRMLARHVFEFSTRIDLRCIAIPYIALRCTICGVGAAFEVSVGQHEQHHLDSLAANKRQFFISSSLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0B5</accession>
    <name>A0A084W0B5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP001202-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011385</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019111">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0B5"/>
    <dbReference type="STRING" id="74873.A0A084W0B5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011385-RA">
        <property type="protein sequence ID" value="ASIC011385-PA"/>
        <property type="gene ID" value="ASIC011385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011385"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005855"/>
    <dbReference type="OMA" id="WQCTLLL"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="106"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="570" mass="63446" checksum="325BBDDAE080F00D" modified="2014-10-29" version="1">MSKMSAEAGSRGIELEDLLAETGQFGRFQLWQCTLLLLPVIFTAFSNLCYVFTAGDVHYRCYVPECDTGSEVIPFTPDWLRDAVPYGANSKFPAKCDRYQPLPRNDTDEAAFVCDANRFNRSAVGRCSSFVFEDPTEKTIVNEFNLTCDDNRWKVTLVGTIHSVGQFVSLAMTGLISDRFGRRWTLLLGVGLGAVLAIVRSFTTSYRSFLTLEFLEAMFGSTSYTTAFILTLELVEPRRRVVVKSVILVAYALAGSVLGLLAMQFRNWRTLSLVLFVPGVVSIPLLFTTVESVRWLVTKDRQATAVRILQRVAKVNGRPPISQNTLDDFCHHQKAKLESEQHSAGRQSFVRLLLQTCQNRHLLLRIANCSFCWFTNAMVYYGLTLNSVTLAGDKYSNFIFITLAEIPPSLAINCILNRFGRRKTQCGSLILSGVFCLLALTALKDITWLNVSLFLMSKMAISLSFSTLYIYTAEIFPTNLRQSFISFCSMVGRFGSMLAPQMPLLQALWAPLPMVLFGSVAVLSGVLVLDFPETTDATLPNTIEEAVELRSPTTKQAPVEPEKGSYCAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W168</accession>
    <name>A0A084W168_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000461-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011792</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W168"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011792-RA">
        <property type="protein sequence ID" value="ASIC011792-PA"/>
        <property type="gene ID" value="ASIC011792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011792"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016429"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8134" checksum="5242138DD7F26746" modified="2014-10-29" version="1">MEDTPSPVAVCQEHDHKMLSSHLSSSDITLLYKSSQVSGYQSIVRMQLKHIYIPDTLTFATKLVLTAGHQECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4C6</accession>
    <name>A0A084W4C6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012898</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020306">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4C6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012898-RA">
        <property type="protein sequence ID" value="ASIC012898-PA"/>
        <property type="gene ID" value="ASIC012898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012898"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="12700" checksum="A8B8177328C093E4" modified="2014-10-29" version="1">MSTILVAFGRLTTSAGCYPCPEAPTSVEGRLIVHESRTENRAASLQLVSGMSNVYYLVRACAETNNANGTVKGLWSNVNNSKTVGKQISESHGCNCILRQDKPIAVTTIAAARQLLSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5Y8</accession>
    <name>A0A084W5Y8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013625</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5Y8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013625-RA">
        <property type="protein sequence ID" value="ASIC013625-PA"/>
        <property type="gene ID" value="ASIC013625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013625"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12382" checksum="D099240DA8E0E5CF" modified="2014-10-29" version="1">MVHQLERDTGHRNHDMRTPAAFAVTQPNNVPELRRSETVAAEAVQNQKNEVTIDIRDFLYRAPPPSVRPLPLQWFVRLRKSVLPGAATASFSLQKVLPPSPLLGRCWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W658</accession>
    <name>A0A084W658_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013650</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525306">
        <property type="protein sequence ID" value="KFB45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W658"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013650-RA">
        <property type="protein sequence ID" value="ASIC013650-PA"/>
        <property type="gene ID" value="ASIC013650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013650"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9585" checksum="090F15AC1ADC8696" modified="2014-10-29" version="1">MPNFMRLSETLARNQLQSALRTDQQGSQSTRKDDTARCETANYAKDKRPEPGELWLLLKESSVSCSPTGPGLARFDERTKANLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6C7</accession>
    <name>A0A084W6C7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006857-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013746</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6C7"/>
    <dbReference type="STRING" id="74873.A0A084W6C7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013746-RA">
        <property type="protein sequence ID" value="ASIC013746-PA"/>
        <property type="gene ID" value="ASIC013746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013746"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011465"/>
    <dbReference type="OMA" id="AIPIANH"/>
    <dbReference type="OrthoDB" id="7737922at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784534" evidence="4">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14769" checksum="F8EAE2DFADF9EFC8" modified="2014-10-29" version="1">MMKIIIATLTLLAVAVFGYEHEHHDYHSHPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLHEADGTERVVEYSSDKHNGFQAHVKRVGHAHHPEVYGHHEEGHSYGGHGHGHASSYANGNLYQHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W713</accession>
    <name>A0A084W713_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013976</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W713"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013976-RA">
        <property type="protein sequence ID" value="ASIC013976-PA"/>
        <property type="gene ID" value="ASIC013976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013976"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11127" checksum="92BDC47B65C3937A" modified="2014-10-29" version="1">MYTPGSCKAAAGSSSTSYVQECRAASGIEYRLEMLELVTMEPEGLEASIFGGKCGFHIRIHSHKRFRLVPEYGWLVSVKSTPELRHGMMLLYTSRRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8C8</accession>
    <name>A0A084W8C8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021411">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8C8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014457-RA">
        <property type="protein sequence ID" value="ASIC014457-PA"/>
        <property type="gene ID" value="ASIC014457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014457"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011954"/>
    <dbReference type="OMA" id="PPCCTTE"/>
    <dbReference type="OrthoDB" id="6611808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="504" mass="55908" checksum="6D9246F668428A9E" modified="2014-10-29" version="1">MHRDLTELPNQANFASILGRGSRAPRSPSYRCWWKRPLIVFDSTNTVHYTWNLRRKEPNVADIRYEEMYDCYGRRNPCPPCGPCAPCGPCGPSGPCDPCGPCGPCGPCDPCGPCVPYGACPPCGPCGPCDPCEPSTRTAHDLNCMPQCPTICPPQRCGPRFITVQQPPRLVAQKKVINCSRTVIDKHVVPQTKAIVEPKLIYQPKTICEPCIIYKRRTVPEPRIIYYKRIVPDPKVVCTPRVVVEPKEICTTLVCQPKPQVVQVPPARDYCCVPAGTTFYNNPYNCPPSLPKPCKSRELRGGLLISNCECLKRNGLQHDCPRSQCQGKPCCLTKPEANCCPSQWSRRYRYVTMGKKSNPVRPSPKCCLPTGGGGCNPCPIDPTCCPPANICDPCCPPMCGPSIPTGCDPCCPPVCDPSYPPVCDPSCSVPYYTLKRIRSAVRQPTPRPKIAKTNWYCPPRRPICRVPLPCHFRAPCKAHCYNVDRCCYPLTRCCAVRWCVSPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W932</accession>
    <name>A0A084W932_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cysteine desulfurase activator complex subunit SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014727</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W932"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014727-RA">
        <property type="protein sequence ID" value="ASIC014727-PA"/>
        <property type="gene ID" value="ASIC014727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014727"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014727-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12251" checksum="44FA587CE5B04E19" modified="2014-10-29" version="1">MPNGGRDGTDPLAWRSLSHPDWLHPSFPREKEILFRLSYHSGEVASDCPRSHRIEPDESTFKRRLVPSTWLAGKYSIPAAPADPWTGVGTGADGILQIVSLFRPAESHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W962</accession>
    <name>A0A084W962_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acteyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014757</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021620">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W962"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014757-RA">
        <property type="protein sequence ID" value="ASIC014757-PA"/>
        <property type="gene ID" value="ASIC014757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014757"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10633" checksum="106947BBA84253FA" modified="2014-10-29" version="1">MALVPELSQRPTRGKLMEAKKNLPIKSEAVTPGKNIGSPPIQPGGERWLPDAGNGERVTPSRIGYRFTQASANRRKVQDVQSPIDPCGFGIYDKSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9B2</accession>
    <name>A0A084W9B2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014812</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9B2"/>
    <dbReference type="STRING" id="74873.A0A084W9B2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014812-RA">
        <property type="protein sequence ID" value="ASIC014812-PA"/>
        <property type="gene ID" value="ASIC014812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014812"/>
    <dbReference type="OMA" id="FGTSHAI"/>
    <dbReference type="OrthoDB" id="550113at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="252" mass="28236" checksum="21FFE82ACEE1AE74" modified="2014-10-29" version="1">MDILPDDLLSYHGEIYNPFTPVVSPTTEGAPTRIDKMYIQTASGYRPVDNTYSYHKSSTLIGGDPESNSNTVSTSVHLSCAVQRVWHLFSTVCHGLLGGLAFAHLLLICTTKPYDWVDASIRHYSAFAEVYANTFYCLAIVCMVSIFDRMDIAHGGESNVSFRSVFIIMIYIMTIMLSLSAGSMDERLYLTATLNSTVWEEELETNKVLSIWNALSIARSVGAIFGWVVVGFLPNQDNLYDQLLEMEKYQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H4</accession>
    <name>A0A084W9H4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Carboxyl-terminal protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525323">
        <property type="protein sequence ID" value="KFB46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9H4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014894-RA">
        <property type="protein sequence ID" value="ASIC014894-PA"/>
        <property type="gene ID" value="ASIC014894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014894"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6061" checksum="66E697062AF9C2CE" modified="2014-10-29" version="1">MNAPSTVANAPEWRTGSRDRSSCTGKSGPIPERAKWRRRTPRDIPSDREPSPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAD4</accession>
    <name>A0A084WAD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015200</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525328">
        <property type="protein sequence ID" value="KFB47178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015200-RA">
        <property type="protein sequence ID" value="ASIC015200-PA"/>
        <property type="gene ID" value="ASIC015200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015200"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015200-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6306" checksum="363502729E75ADD4" modified="2014-10-29" version="1">MERRAKETLQFYCSTLLVEEALEALVSVIPVQGMVVPAGIRNWFWNRTYSEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBH6</accession>
    <name>A0A084WBH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00015536</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022357">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBH6"/>
    <dbReference type="STRING" id="74873.A0A084WBH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015536-RA">
        <property type="protein sequence ID" value="ASIC015536-PA"/>
        <property type="gene ID" value="ASIC015536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015536"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022700"/>
    <dbReference type="OMA" id="FATSEWC"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="266" mass="30748" checksum="16F7E254FEE4A304" modified="2014-10-29" version="1">MAKPMISELKMIILIGQHLNIVNLIGAVTENIQNNELMIVLEYCRYGSVLEFIRKKKSNFVDSMDPQHDSRQTENLEQSNGGLRTTFQTIDFICWAKQVADGMNYLASKNVIHGDLAARNVLLCEDNVVKISDFGLARSFNYKNMYKKKGKDRVPYKWLALESISDQIFSVASDVWAYGVFLWELFSLGTVPYPGIPLDEHFYHLLHGGYRMEQPRYANRPIYDVMLLCWNENPNLRPTFDKLARVFNAMLPKELQDLRLISVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBH9</accession>
    <name>A0A084WBH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015540</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015540-RA">
        <property type="protein sequence ID" value="ASIC015540-PA"/>
        <property type="gene ID" value="ASIC015540"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015540"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7188" checksum="318FACD70E745204" modified="2014-10-29" version="1">MANRKKDAAALPTCNEVPVKFIFPTQSSNFMAKEKLPSDSDSANKYHWSRLRRCDASLGGANEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC49</accession>
    <name>A0A084WC49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015867</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015867-RA">
        <property type="protein sequence ID" value="ASIC015867-PA"/>
        <property type="gene ID" value="ASIC015867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015867"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015867-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9972" checksum="0D4DAEEA2A8217E3" modified="2014-10-29" version="1">MIHIRPIGAQDTSVFVPLMGSSNVVVVMEAEVMVSLSLASIRTPKVTVLSFMSPFHTENGPHMSKIWDPRKSSKKEVKGDRSEGENGMESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC74</accession>
    <name>A0A084WC74_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01022579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC74"/>
    <dbReference type="STRING" id="74873.A0A084WC74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015774-RA">
        <property type="protein sequence ID" value="ASIC015774-PA"/>
        <property type="gene ID" value="ASIC015774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015774"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009280"/>
    <dbReference type="OMA" id="WADACLL"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="231" mass="25509" checksum="2371BA310B3A1025" modified="2014-10-29" version="1">MKTEEKTNVPRVRIAVLGNVDVGKSALTVRYLTRRFIGEYSSNTDLLYKQTVTLDSGVLDVEIVDISAENDNGFPVEQIQWADACLIVYSITDRSSYEYAQRSLAELRQLQNAPSAYLVGNKADLDHLREVQETEGASLAASHAIGFCEVSVADNTPALYKAFERLLVESRARPVKPRKFSVSKMFGTLIGSNGTRQPPASQGTVVPCHKGELHKSRVMKRRQAFTATASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC80</accession>
    <name>A0A084WC80_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="9">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00015876</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01022583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525334">
        <property type="protein sequence ID" value="KFB47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC80"/>
    <dbReference type="STRING" id="74873.A0A084WC80"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015876-RA">
        <property type="protein sequence ID" value="ASIC015876-PA"/>
        <property type="gene ID" value="ASIC015876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015876"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006085"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000030">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="204"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="16">
        <location>
            <begin position="388"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="17">
        <location>
            <begin position="777"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015876-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="999" mass="114641" checksum="07EAB35C911B4113" modified="2014-10-29" version="1">MTATAIQSCNRTSFERSNDITKSAQDNREYRGLKLSNGMKIILVSDPTTDRSAAALSVAVGHLCDPTDLPGLAHLCEHMLFLGTKKYPLEHEYTTFLKEHGGSSNAATFSDMTKYYFDVIPDKLEDALDRFSQFFIAPLFNEDVTDREINAVNSEHEKNLSQDMWRVKQVNKSLCKASHAYNRFGSGSKETLYENPRQNNINVRNELMKFHNKWYSPNIMSLAVFGKESLDDLERIVIQMFSQIENKNVTAPSWPDMPYDDDQLGTKTYIIPVKDTRSLTISFQLEDLEQYYKAGPEHYVSHLVGHEGKGSILSELKARGWCNKLISGYSNLGRGFGCFEIMVDLTEDGFNHIDDTAKIIFQYLNMLRLQGPQKWIFEEYRNLCDMLFRFKDKESSLSVVTNVVTAMHVFPLEDVLTAHCLISEWRPDLIEDLMSKLTPSKARIIIVGQQCSSLTNAEERWYGTKYGVHKIEASTLEYWSSADLNTNLQLPEPNPFIPTNFDLLPTDSDVDTFPTVIYDTPMIRLWFKQDVEFLKPKTMMNFDFNSPLVYSDPLNCNMTRLFVQLLKDHLNEFLFEADLAGLGFGVGNTTSGISLSIGGYSHKQHILLEKVLDSMFNFKIDERRFEVFKEQYIRSLKNYQTEQPYQHAIYYLALLLTELAWTRQELLDSMQLLTMERLQAFVDQLLSRMHVEGFIYGNVNKDKAMTMMRMVENKMKTTDSEVVPLLARQLLQKREYKLGNGESCLFEATNEFHKSSCTELYLQCGPQEPHSTYVDILSQMLSEACYTQLRTKEQLGYLVFCGSRKANGISGIRIIVQSAHHPAYVEERIENFFNNMLDYLEKMPDDEFNRHKEALVALFLEKPKRLASQFSIFLQEISLRQYHFNRAQVEAAKLRTLTKQQVIDYYKEYIILGGPSRSTLSVHVLSTGEGGAGANGIKTAELEAAEEIFDDSIASHRKEITKKEFVRVTDLASFKSSRSLYPLVQPYLEILPKGGRCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCM1</accession>
    <name>A0A084WCM1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016017</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022753">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525336">
        <property type="protein sequence ID" value="KFB47965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCM1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016017-RA">
        <property type="protein sequence ID" value="ASIC016017-PA"/>
        <property type="gene ID" value="ASIC016017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016017"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7703" checksum="9A817F7C9F21A4F7" modified="2014-10-29" version="1">MYLIMVIPALPTSSTSYRSGAYLQYEDVKLVRISEASGRCIQKPTHPKTDSNRLVNELNRISAERWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDL0</accession>
    <name>A0A084WDL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016283</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016283-RA">
        <property type="protein sequence ID" value="ASIC016283-PA"/>
        <property type="gene ID" value="ASIC016283"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016283"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016283-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="28223" checksum="886AE197DC9C77BB" modified="2014-10-29" version="1">MSTAMSTAFMVDSILQDKDAMNEQAASPVGVTPGTVAGDSSLASVSDSDEFEEPKDTAGLCDSPKSYHGVHHHHHHHHLLHHHPANDHLHLHHHHLMHHHHHQQHNNHAAYSDDELPVGPPPTNGVTILGRPAPFRSPRADEEQMDFCCAKCGHCQAELNPSAGRSSPGAVARGGADKRPADGESNNNNNTNTKNESASESGGASESGGEFEFKCEKCGFGQYVTPGKQTILKESAKPVLKFSVSAILGDKKECVKVRNEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDL1</accession>
    <name>A0A084WDL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016284</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016284-RA">
        <property type="protein sequence ID" value="ASIC016284-PA"/>
        <property type="gene ID" value="ASIC016284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016284"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="15308" checksum="73FAE2CF439A0D16" modified="2014-10-29" version="1">MRVLLLIFLKKVNIWEGKREVSYFGNFENISIQYRAKVPAREKSTWKETVGGLRQAEKNAYSVGQIRKGGKCVQYIELDDWETPWPVNDELVTNCGWNTWCRQITGRACQHQTTDWDNPPQHRCSKANFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDW9</accession>
    <name>A0A084WDW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016538</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023078">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016538-RA">
        <property type="protein sequence ID" value="ASIC016538-PA"/>
        <property type="gene ID" value="ASIC016538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016538"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11598" checksum="C090AB57246408A4" modified="2014-10-29" version="1">MENAIRWTDTEKEEWTEMVPPSLNGGPIFAIISLPAPNHSRAPVEWCPAIGGWMEDGDIHLFVCELNSNRTIGRVGKKRRKPSDGETVRKIKSESEPAYDAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF47</accession>
    <name>A0A084WF47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017097</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017097-RA">
        <property type="protein sequence ID" value="ASIC017097-PA"/>
        <property type="gene ID" value="ASIC017097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017097"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017097-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6304" checksum="D05CDEF2E4CF7CC7" modified="2014-10-29" version="1">MKFRQPTCLFSVLFGRTGFGGLDFTTTNTTTTTTTTTTTSTTAGSRPKLVRGEPAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFI3</accession>
    <name>A0A084WFI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016981</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFI3"/>
    <dbReference type="STRING" id="74873.A0A084WFI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016981-RA">
        <property type="protein sequence ID" value="ASIC016981-PA"/>
        <property type="gene ID" value="ASIC016981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016981"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010826"/>
    <dbReference type="OMA" id="HKCDCKM"/>
    <dbReference type="OrthoDB" id="28697at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF7">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="993" mass="111550" checksum="97756758186E9278" modified="2014-10-29" version="1">MSSEKTPSEPGTPSLPGRLHRWPTQHLVPRPGRSTAPSPVPTPVVPSGRSDNHKRRRWMMLNDFVAYENHYFTALQLLTYKFHDELLKNESVLQRSKARTIFAFLPELCELHRHFDGWMDHVVRGWEERPLLGGLLGAMLEQPGLVQLYRAYVNNYQTAHTVLAAELLGNESFRSYVDSALVQSVENLTIEGFLLKPVLRITRLLQQIREMLECTPNGHCDRQPLQRCFVRAEQLVRQLEDLREYNIILGQLQMSAGNAWGTPGALLHCEDLIVEPQQEGEPTPGGQQLKRRRVYLLRDRVLSVKLRKYSSPPTISSQRLFKLFQDNSEASVKWTVPLEDVDIFVGGQTSLQPSTSVDRCNEMLHLRSDYIIMQKIRLLSSRLNHSVAYLTPTHLDALLHSIEVEIQVQPLLHHLIVSYFSYAYTHSRPMQQKNNEAQDGSRPPNPCWMQVLPKYGRPEVGRLRESAFCLRNMASTSKWRVMARLAQLALQPENASGWWKEGATQHFSIADPQFAGRFAVARDLINAEITGACYYAPNIKSPLYARLKLQAWLKHRNTLWICSSQSTEPKRSCVTLFTHDLLDNTVTERTSFFLEGEYVEGIAHVPEGTVCTVDEDRREKSIDTVWIVTQTRLVIYSAAYPFNDALLANVDVHGGPKHILHTPECVVVGLTNGEILVYQKLGDEWDLRQPLEVMLCGLPIGAMMAVGRDIYVATGTVITMFCGGSIVRALRQFPVKPLSDRFGKLPATDIHLMEYSIHGIWIVRQRSLVVSHFHPGTMKHLQDLDIGDPVLRFVAAKQSTEEPGQVLIAPMLHITALLATRDMLVVGTNVGITLKLSLPAYANLPVIGGPWSVSYQSHLDSVSLLLALATTPQPEADDAQYGPFDIEMYKHSRRTSQDLGNGPVVSDEQDKTAEPRKNHARTVLFVSGGRGYRSCSGTGATNTVAPMGSFKHSDTSAGGSSSSLSCTDSQIILWEMEINSFPPRKWPAQPHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG17</accession>
    <name>A0A084WG17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Usp family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017318</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023429">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017318-RA">
        <property type="protein sequence ID" value="ASIC017318-PA"/>
        <property type="gene ID" value="ASIC017318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017318"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="147" mass="15655" checksum="7EE614ACB3BF08FC" modified="2014-10-29" version="1">MSCVRKGFVLVDGGMVVPRLEIEAMATTVASGGNRVRPRYVGINGINNEFACFPKAKPFGAKGLGLVERKMENVLARKIGHIHTHASGAFSRFTAVTVADADGSVYFKPTVEKGAAKGWVKMVVTAFTGDKHLIVSARVCVCVCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGA5</accession>
    <name>A0A084WGA5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017358</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in muscle cell metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGA5"/>
    <dbReference type="STRING" id="74873.A0A084WGA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017358-RA">
        <property type="protein sequence ID" value="ASIC017358-PA"/>
        <property type="gene ID" value="ASIC017358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017358"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002054"/>
    <dbReference type="OMA" id="LMNFAAW"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000020">
        <property type="entry name" value="Cytochrome b5-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053100">
        <property type="entry name" value="Cytochrome_b5-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740:SF1">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="434" mass="50115" checksum="3F5C3120810092DE" modified="2014-10-29" version="1">MASAYITTISKKYPSFRDEPLKTVHRWLDAKRQDDGAEGLWRIHDTLYDFTDFIERHPGGPEWLRLTKGTDITEAFETHHITLRAEGLLGKYKVRDATGPRAVRLTFRDDGFYRTLKRRVRDKLKDVDHTPAKRSKLIIDSMLTAAFGLAFLAIRLGSYTLGAASGLFVCWTMIGAHNFFHQRDNWRMLTFNLAFSSYREWRVSHAMSHHNFPNSILDLEISYFEPYLCWLPNPALKGPVKRIAAWVYGPLVYSLLFYGEFVKRLVETYQTGKNTFFLDDLVTLILPTFMYVVGATSLWEVVKMWLFIVLVASFLFGLIGLNAAHHHPKAVHDGDQIPADIDFAVYQMAAVIDRSDTKGSQFMVLTSFGDHCLHHLFPTLDHGILPQLYPVFFETCREFETVYREMPWLQQIIGQHKQLARVETTTYNPSEKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGJ9</accession>
    <name>A0A084WGJ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017347</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGJ9"/>
    <dbReference type="STRING" id="74873.A0A084WGJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017347-RA">
        <property type="protein sequence ID" value="ASIC017347-PA"/>
        <property type="gene ID" value="ASIC017347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017347"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001799"/>
    <dbReference type="OMA" id="ICVASMK"/>
    <dbReference type="OrthoDB" id="532682at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000113">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017347-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="411" mass="45670" checksum="903A9B479D15E82D" modified="2014-10-29" version="1">MDAEKSSSSSFEDLSNLNEQERAELASSVPEATQSKPVKEQSQEQRPEPEDSEKGASKPDASESEPEYMDILGNGTLLKKVLTKGRSENRPESKDIVVITYSGRLEDGTVVEEQTNFVVQVDDVEVVQGLDMALKLMNEGEVAEVIVNARFGYGELGVKDPTEHDPVKRTVPPNATITYTVELVSIKEEGDVETRSYASRKEIGNKKRLRGNFWMKRQEYNLAIQSYRRSLEYLDDTVSAGGMMESGAGTVELSPTELQDLLEDRMKVYNNLALAQLKISAYDAALKSVDHVLKCQPTNAKALYRKGKVLDAKGDTKGAITLLQKAATLDVDDKLIQSELSKLILKSKREARNEKDLYQKMLGQAQKLEQKTKTAPVTQNTESSKLKMWGYLVGTILFGVAGVAIYRYNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIJ0</accession>
    <name>A0A084WIJ0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">triacylglycerol lipase</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00018078</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01023934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIJ0"/>
    <dbReference type="STRING" id="74873.A0A084WIJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018078-RA">
        <property type="protein sequence ID" value="ASIC018078-PA"/>
        <property type="gene ID" value="ASIC018078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018078"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021459"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021809"/>
    <dbReference type="OMA" id="CKECTQH"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07218">
        <property type="entry name" value="Pat_iPLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000003">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000017">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000090">
        <property type="entry name" value="two pore potassium channel protein sup-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="18">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018078-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="927" mass="103424" checksum="9A84E4F4A1F6B7C8" modified="2014-10-29" version="1">MNLSFAGCGFLGIYHVGVAVAFKKYAPHLLLHRISGASAGSLAACCLLCDMPLGEMTSDFFRVVNEARSHSLGPFSPRFNIQTCLLEGLQKFLPPDAHERVNGKLHISLTRVYDGKNVIVSQFNSREDLLQALLCACFIPVFSGLLPPRFHGVRYMDGAFSDNLPTLDENTVTVSPFCGESDICPRDNSSQMFHVNWANTSIELSKENINRFGRILFPPKPEILSSFCQQGFDDALNFLHRNNLISCTRCLAVQSTFVVAEQPSSNLEEKILEEYDPECSECKECTQHRNNALVGSMPDNVLTVFQTYIEQANKGLINWVFRHRGSKLLTALSLPATLPADIVCATLTKLMGAAPSIGKQLWAVSEFVLKNLSTILLKVRRRQKQQLTANLQCQIALTEYNQSATQQQHHHSHRSSIIDMRMEEGKSFGKEMTPSYSGHHSVVGDIDAFDHILQVSSNHDAMYAYYYMDEDNKVKVTEIFDMSESDNPAIQTANERELNQQLEFDTDWETTQPDFLYTNSYDGDNMIDIEEFIDPSIFMNGNHHHHLNNNNNNNNNNGIQSTLTQYPINAWECSQVQIEELPSDFNDPSLEPEADQQTSLIAEDFKVIETVIMKSEPHKAGQQWKFSGAFYYATTVLTTIGYGHSTPSTVSGKIFTMCYAAIGIPLGLVMFQSIGERVNRLSSVIVHAVKTSFNCKKAIASEVDLILVVTTLSSLTIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVALQKDNALNKKPEYVAFALIFILFGLAVVAASLNLLVLRFVTMNTEDEKRDEAQAIQALQIAVKLDGDIITGNTGDSVDERCYERISVINPLTVCHNCPTKFDMTEAGNGCYIDTSYRYPLMDCEMTQLRSPAATVDRGGQRFHASAGQDFETDDEGLIRPLRYDFHPSRGRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ32</accession>
    <name>A0A084WJ32_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP011746-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00018297</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ32"/>
    <dbReference type="STRING" id="74873.A0A084WJ32"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018297-RA">
        <property type="protein sequence ID" value="ASIC018297-PA"/>
        <property type="gene ID" value="ASIC018297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018297"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019236"/>
    <dbReference type="OrthoDB" id="6286493at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052131">
        <property type="entry name" value="ATRX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="194"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="618"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="700"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116370" checksum="28001E484236C911" modified="2014-10-29" version="1">MTEECYDEDGFRLSFESDTDPAEKRYFMRLYPNVSKIAESKVHCTACQTHIGTAPVSETIIRMHPVLRVTHCRSCHAFYNSGEFDKGEDGSELYCRWCGQGGEVYCCSKCPYVFCKSCILKNLSKNCVQDIARNENWDCFGCAPKIMWHLRAQHWALMNFIEKQKKDIQALHHLPAIAINNLLKQDLTTCCPNKGSRSKGANQSGLEKPSSSPSSMSISSPKPSGSGSKPQKKLKQKQSRTPDEEHQSPAPPPQKKTKTGDNEVVCTPDIMSMFTQMEEARAPVAASQTANSSVFAVGSVYNMPSNNINAPSGPGPASVDMQPNTPVATSSSAAKPRAILHNSMGRSVTVRLASADAASSQQANSVPDPKSQFVRLSPTASGRQLGAPNVYHTINGFRVDLHTAAQQGTYRLPNGKLIQVRRQASDTPASTVGVTRLVPDLSTNYAASETVAPLLQQQQPVSHTVQLPPNRTNMVPPSQMPQANMLPVLHMLRGLVAGPHADSPLGTARKDFEEKLLGTVEACNHIIVKIHTLTQSNSFKSIRNLRDLKELFIHLSYLLTYGKGRLISLHDRCVEDVKKMGFTKPSDFVMMGENVSNRNPEDSEDEDNDDCEIIEQNTTVIQVDSDDETSAGGGKTTLPAKKALGASRRSDPPREANNLPTKMHPTAAKKPVEKAATVEKTISYAFGNINVSWQLDSSSSMDNQQAAEKEAPSNISNAESTKSSAPGQVPNDATPDGTGKENESANVTVEMHKENEESVGANTSFNPDDVVELIEMDETESMGEATEALENDGTSNDPTLNEKQSADADIATSLETDSLSPAKNLAELVEISAKDVSELLNIDHQSQIDGDSSMGDATVEASNPMEESSSVSDKNCTEVSVNGSPKETATNATTEEENKSTNENRSETDRTDDKEEQSVVAVEKEPTESMDVIDSVEENKAGPKQHDGLEGMEVSASNEETVLKATSEIEESRPTIKESNPICLEKETTSAVLSAEEEESVSVPEKSASTSTVNDDATEPKDKVISVEENESESKQNEEMEMEASDDKTLPNTDSEGKTKIQLSMPRMKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJG6</accession>
    <name>A0A084WJG6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJG6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018632-RA">
        <property type="protein sequence ID" value="ASIC018632-PA"/>
        <property type="gene ID" value="ASIC018632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018632"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="264" mass="28492" checksum="1964F7EDA823AE05" modified="2014-10-29" version="1">MIRSWPQNATHSTRRTKNQNNPQQGLARAQLSSVPGRSPIRDPLPIPAQISEAGSSVKVWPSVGRSFVGSDIPVLRSPRSLPPGADRVGPGGVNRWVGHLRCGKREGKVGGALGGPRDGIPNRARTSERDRRCSERVDRQTSSSWGRGCRIGPVGGTERGVSGLECYYSTERGVSCWWRSLSLSSCSRECDSGRVEVVLMGRRRARNGIDRVPASLEGGPFFCKPQVQSPHEDKNGNWLSTCCGHVAVREVVCSGTASRGLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJQ1</accession>
    <name>A0A084WJQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018476</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024046">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018476-RA">
        <property type="protein sequence ID" value="ASIC018476-PA"/>
        <property type="gene ID" value="ASIC018476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018476"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="20411" checksum="C83843EF27BD4967" modified="2014-10-29" version="1">MRDARGDTFRCLIVPWCVGVREPWSREANRWRGSTEVQDDKTTTTRMRSQPPWFCGVPPCAISVAQYSDTRVISAADRKLESWYFPSRFRVEVWLWLFACASQQVFDEPRRDGHKPQRPEWQVIFAVPQEVPSPLSSCFGALFCPHISARVQLLRARSYAVPQSANFGPNIYGTTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL41</accession>
    <name>A0A084WL41_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Endoribonuclease SymE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018974</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018974-RA">
        <property type="protein sequence ID" value="ASIC018974-PA"/>
        <property type="gene ID" value="ASIC018974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018974"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8581" checksum="DB277CC979F861B7" modified="2014-10-29" version="1">MEKNPDCSINGNRRPVIVKYISRQDNHDRRFPIGVFEGLWLTFAGYGTDDEEGSEYSSSSSIRNAFVLDMDLCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL67</accession>
    <name>A0A084WL67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019003</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019003-RA">
        <property type="protein sequence ID" value="ASIC019003-PA"/>
        <property type="gene ID" value="ASIC019003"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019003"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019003-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="28040" checksum="0037A3DA11B33233" modified="2014-10-29" version="1">MRASAAVGTFSSHRVNQVASAYTIIIIAGSIAPDPGASHRCIWIKRIALPVGAPVLIMHAGKPTQLTDLVTVKKSKVIAVARLRNSRPHQAVEEILTGIETQAGNLPVNGYNRAMGTEITLLVPGSRSLVRKSCAYDSMRAFRKASIRRTHARTGLPNKSYLVIESSPSVGVILSEKWFFRFPRDRVAVGQKLLKGHASAKLISHLNLDCRLQWVTTCPEISVEQRNSLMVPEHARNIIIITNVIPIGDRVLGCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLC4</accession>
    <name>A0A084WLC4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein futsch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019065</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019065-RA">
        <property type="protein sequence ID" value="ASIC019065-PA"/>
        <property type="gene ID" value="ASIC019065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019065"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015515"/>
    <dbReference type="OMA" id="DSIEYMS"/>
    <dbReference type="OrthoDB" id="7791004at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019065-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120005" checksum="21536F7313C5F798" modified="2014-10-29" version="1">MGNVLCKEPNTNASPSTGNTFSNLSSVICPNGLGKGKTHPMRKTYFTRSAVDASKKTTSATGWQSVGLHVPSASPKVIDTPPVAPPRKKRGATLDGRYRSDDSLQVKNGFQDVFGRESRRHSCHDIAPGARPASVPPPRPEMPALPARQTSCFEIDASNDAFSDFSKVPTTAELEKSPAATSQIPRVGNRKSDKFFGERLADSLSSGETVAMIGEVKGDEKPRGKKLEPTVDDVDKIEKFVETVQDSVPVVAVERRKHASENRKSVATEPPKEVSGQGLQEAPKEGSTTNDEEEDLMKYIDRTVSADNQIGRRAEFLMAMLEDYNDSVRYDGMQPVEEPLIVPKRRKSRHICDDHDHLHAKLHEHEKEASQGAANVIRTEASIELAPRKPSRDFSKYKPIEPEPDELFDSEDEPPIARPARMKQKATPGKQREELPAPPAPPKFQKSLSESQFDRQLATSDVTSTAPPPPPVKPPPEDGGGDSTPKAHTPRMLKRIISMPATEHLGREPSGAPQRPPLTKSSSSGSFAAVDLQRTRISVERFTPEDYAHHTGVDELVKPKSKLTTRKISWKSTEPPNCRTPTPTQERPSNPSFTIGGSEVVTTVDSSNTLCPPEPPRRKRSDTSTEMGSIGEREPKEEVTETKLSQAKLYQQLHSKPEDNSLRKFCLGSFIESSNVLQHHDVVNVLDRVYTASDNDENIVEQFQAYLEEQLNAELDEPNPTNPNIAKLLEKLSRADNTPASKEKEDETLESVKIELVGSSLSGGSTSSQGKSSDVDDCFDPEFEKIEKSEIVGELPKIDPKHAVYAGRRRDSIEYMSDWFGGDSDGSNSMLSVAGEDRGSTGRIHEPVGRKGTHPPHGGRRESIEDVGQWFSNHNILRPSFGEEFEEPSRRLRRGSDSFLGYDQHRQYPFGQGRNRSESQSAELFEDITKLQEQHKDDGVPPVAGGIVISPHQAKRKVLEHRNSSDALLMKVLNKPHLAQLVNTTPKKQGSAEKLNTKPEENAVKPSETTTTTTTTTTTTTTTSDEENKPLLKPDEPSASNVQDSKQLTANNEKVSLSSDATKGDQHQEPHNEHSTLLKFLSKENLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM74</accession>
    <name>A0A084WM74_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM74"/>
    <dbReference type="STRING" id="74873.A0A084WM74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019372-RA">
        <property type="protein sequence ID" value="ASIC019372-PA"/>
        <property type="gene ID" value="ASIC019372"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019372"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020545"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019372-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="338" mass="38086" checksum="639D0CEBEFE89452" modified="2014-10-29" version="1">MPSELSTTKVIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRAKGVLDVSNSFAVPFDEDDKDKSVWFLDHDYLENMYGMFKKVNARERVVGWYHTGPKLCQNDIAINELIRRYCPNSVLVIIDAKPKDLGLPTEAYIAVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQKITNQLLGLKGLNAQLRDIKNYLLKVGNGQLPINHQIVYQLQDILNLLPDITQENFTDTLYVKTNDQMLVVYLASLVRSIIALHNLINNKLTNRDAEEGKKNDDAKDKKAQENKEAGSDKDKSKKENEKDAKKEDVKAEKGKDEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WME1</accession>
    <name>A0A084WME1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP006642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00019754</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WME1"/>
    <dbReference type="STRING" id="74873.A0A084WME1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019754-RA">
        <property type="protein sequence ID" value="ASIC019754-PA"/>
        <property type="gene ID" value="ASIC019754"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019754"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003438"/>
    <dbReference type="OMA" id="SIVIRNW"/>
    <dbReference type="OrthoDB" id="10052721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11585">
        <property type="entry name" value="SATB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.710:FF:000002">
        <property type="entry name" value="Defective proventriculus, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000169">
        <property type="entry name" value="DNA-binding protein SATB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16534">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="11">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="618"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="620"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="457"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019754-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="734" mass="81836" checksum="E70DE8019AF14DA7" modified="2014-10-29" version="1">MELAQSLEQKRRLGPGWLGGRPIAPVDPVDLANHAIAKSLPLHCVVESVSSLQATLNFDTRSPWKRRPNIETDSYVIIPAATPFCDIVTTALQRLGYSTEISNAARGSISIKNWKSLSLDAISDNPLVSVSDILGELTSVVTLKITILRNKPSQLAEIKDKLLKLLILQSHALLRSTGCPLDEITLSQICRSPLQNTFPFTPEITDETRRNFDQWWSNQLAPQPNPIAHKILPFANPQPNDHLDFPGHGAFPGLHTGKRDGGLLEAGAGAHHPNPHHNLVVHPALQTVHSQYPNQKTRMRTSFDPEMELPKLQRWFQENPHPSRQQIQSYVVQLNSLESRRGRKPLDVNNVVYWFKNARAAQKRAEMRQGMTNGFGTPSMMLSQADYMKSSPSAPSEDIDNLSQDEMDDELDRPMSPQLPLSLTIHERNHPLTPSDQTPIKQEHNSGPGSPPPSPTPNHVLNSSSSVGSNNNNNNHGSTNSNSNNGAGLNSSSNNNNGNNESANDSAIVNDEPKSNYSNERSSSPQRSSRSPASEDLDMDEPDVSNLDDYRSPSPDSKRQLPFAMNNPMLSHSIMYMSHYIPAMQGAAGMHLKSEFSPGAHGALGQGGLNLSFNSDERRKRNRTFIDPVTEVPKLEQWFSMNTHPSHNLILKYTEDLNRMPYRQKFPRLESKNVQFWFKNRRAKCKRLKMSLYDPAQLANLGDQAHLAALHDAPHLSSLHDTAQLHPFHHAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNJ1</accession>
    <name>A0A084WNJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019937</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019937-RA">
        <property type="protein sequence ID" value="ASIC019937-PA"/>
        <property type="gene ID" value="ASIC019937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019937"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14985" checksum="8F1AF8BCA2A92A1D" modified="2014-10-29" version="1">MATTRDIAPRSGRQKRPAHRLTSDRCALQKRAPDRGSGRTAQEEEEDDRRCQAMTECKPFSKAHGLELPEWSAGQLRKDWHTVFTRPVSTGAHTPRHFTKASGVNLLSPDDTACGNGRSQWRLVVPAVTTFSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNQ9</accession>
    <name>A0A084WNQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024663">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525356">
        <property type="protein sequence ID" value="KFB51853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNQ9"/>
    <dbReference type="STRING" id="74873.A0A084WNQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020030-RA">
        <property type="protein sequence ID" value="ASIC020030-PA"/>
        <property type="gene ID" value="ASIC020030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020030"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012038"/>
    <dbReference type="OMA" id="CKASEHA"/>
    <dbReference type="OrthoDB" id="7741570at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785189" evidence="3">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="30810" checksum="DADA1B1140364954" modified="2014-10-29" version="1">MHSNARYIVWLVLVTAGYLVRQCCQASADHVPAASARKLSAGLTAMHFNHLFSHGEGFPGPTPALGPGESVKFTANKQHVLHPVDAAWRMSVGLGTGSSSNNWRVRKPLAKPVPGSRSRINNRSMTRFSEVEIPPGLEERELEVVQQVTPAPGPTRAGNVTGLVELFRSAERSRGIENFLWKYFVDGDVSASTEDDDDGGEGGAATKGTRHSAADRSDAVGRKKKFHLKKKYKKFLIPLLLAYKIKFLALVPAIIGGLILLVKSAGLAGFFFALFTAVVSLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPK7</accession>
    <name>A0A084WPK7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00020477</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01025096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WPK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020477-RA">
        <property type="protein sequence ID" value="ASIC020477-PA"/>
        <property type="gene ID" value="ASIC020477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020477"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000867"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003300"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006225"/>
    <dbReference type="OrthoDB" id="5987976at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:regulation of dendrite morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd00078">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF320">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF56204">
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        <property type="entry name" value="WW_DOMAIN_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="760"/>
            <end position="793"/>
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    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="351"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
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            <begin position="75"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1355" mass="148412" checksum="7244F9113C2E44AD" modified="2014-10-29" version="1">MSSGSQTGEPESSPPPSARSESEERQEPTTGPVDTGRDGSENGDSEEGEHGLAIGGADAAGVERSADGTPVSATDSEDEEEEEEEEEEEPPELRAATEQQDFPPTPYEECLDMKMFEIQTEPSGTADEAGEPSGQEATSPAGTSDVPDGEGTSFRDTEEILPGNVEGKETPETLPGEKDKLAVSEVPSEVGELQQPSPSNEEAESSTCFGVRRKSELPSDGGTVSRVEQPVVNGTKKKVRPNRLSPTTPASRSSGYRARKNHFWLGPEAVDAKPLAGPGELCFGASVESPTKLHRPLERSWPPKTTQRDPDGLESARHRQRQRQRQGAGEFSFDIIDTDEQEQVEGAVGGMYDYESHVVNLEREEAGDEEQVEGSSDQRQPQRLDSNGNDAPESGDDGTMASASSATPAISKIPLRKAVKNVLPSEVGCLELAGLEAIGGDASLDLDPAADLPAPSLDPADAGRSKSCXXXXXXXARRLRAAAAAASGTTVTTLLDEFGPPELRTNRMPDQMLAASLVIAHPPASEEVPDESGASRSADAVVRHVPSIRLPSIPERARAILAEQDVEPLPPAWEARMDSHGRIFYIDHATRTTSWQRPGPGHASTSATTLPHGSDPHRQQLDRRYQSIRRTIYEHMQRHDGNGVPSNRASTSSGISVTDGAVISARPRTSSTGGRSNSIGTTAGSSSSTPGAFHPALLMICRSDFYSMLHTNGDAIAIYNRNAALKHMVSRVRRDPACFGRYQHNRDLVALVNCFAATGADLPTGWETKLDQSGKQFFIDHVNRKTSFMDPRLPTEGPRGRHHQAAGGGPGPTLLLAGPPAPAVLVPGAFVDDRPVPPPRPPTTISRLANIGSPEIPVAYNDKVVAFLRQPNILEILRERHGSAACSRNLREKINAIRVEGTTALDRYSHDLELTILLSLFEDEVMTYVPPRARSPPDQGSPSLGGVGGGAGVGGGGGGGRHVQRAPPLVRRDFEAKLRTFYRKLEAKGFGQGPHKLKVQVRRAHLVNDAFERIMAASRRDLQRGRLNVVWDTEEGLDYGGPSREFFYLLSRQLFNPYRNMYEYSANDIYTVQIAPAKDNEDKLPWYRFSGRVLGLALIHHCLLDAFFTRPFYKALLRLPVSLSDLESLDSSFHQSLLWIRDNDMGNGSELGLHFIVTEERPDGTSLDIELKPNGRSIPVTERNKRDYLERIIKWRLERGVLEQTEWLLRGFYEVVDHRLVSMFDASELELVISGTVEIDVADWRNNTEYRGGYHDTHVVIVWFWDVIERFSNEQRLRLLQFVTGTSSIPHDGFAGLRGSNGLRRFCIEKWGKPNALPRAHTCFNRLDLPLYPTPDVLYEKLVLAVEETNTFGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPT6</accession>
    <name>A0A084WPT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000051-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00020342</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025130">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPT6"/>
    <dbReference type="STRING" id="74873.A0A084WPT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020342-RA">
        <property type="protein sequence ID" value="ASIC020342-PA"/>
        <property type="gene ID" value="ASIC020342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020342"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005102"/>
    <dbReference type="OMA" id="AQINKHW"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF106">
        <property type="entry name" value="CURLY SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="730" mass="83103" checksum="CACD5D3BCD7CD19D" modified="2014-10-29" version="1">MWVVTHGNYWMRYCVLCHLVHAGLQKNTYGLLAIAAAIAIVGIHGQFLAFDQHATECALYVNGPGKSSAFDYNLNLFRGTISPLHAEQTTCITYDAINQAYLDARKRIRVSQPKGDWKTEDIATVGELLLDISIQLARTYGLSYEEIEKGLPSIDTSKTLIREVCPAFLSGVECRPGKYRRVDGLCNNLKHPTWGAAMTPFQRLIGPLYSDGINAPRISITGHDLPLSRVVSRTIHPDEGYHDHAGTVFVIAWGQFMDHDFTLTATPLDPINRNDPEECCKRPPHLKHPYCNEIRVPDDDYFYRLFNVKCIDFVRGFPSPRPGCRLGSRQQFNTLTSVIDGNTIYGVNEKFTRKLRTGYNGLLRMNPVFAEYGLKDLLPLKLDIPDEGCTRPNKSMFCFEAGEIRVNEQLVLTCMHTLLAREHNRIATELGKINPHWDDETLFQESRRINIAIIQHITYNEFLPILLGKEVMEKFGLLTQKEGYWDGYDETVNPAIIDSFASAAFRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVYDEYLMGLMNQVAQAMDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGVPGYMEFRKFCGLPTSDSFQELFGSMPNETVRRYESIFEHPADVDLWSGGVSERSLPGSMLGPTFACIIATQFSYVRRGDRFWYELPNQPSSFTPEQLQEVRKAKLARLICDNTDLIDTVQIYPMVLPDHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQG5</accession>
    <name>A0A084WQG5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TIMELESS-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020700</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQG5"/>
    <dbReference type="STRING" id="74873.A0A084WQG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020700-RA">
        <property type="protein sequence ID" value="ASIC020700-PA"/>
        <property type="gene ID" value="ASIC020700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020700"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010970"/>
    <dbReference type="OMA" id="GLYREWH"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="288" mass="32165" checksum="50CBE5ED307EC609" modified="2014-10-29" version="1">MDHYDHLFGDTLAQEENEGEIPSDGELPADDDGGDGNDDGTGGPPQPIKLEPKKKTVRNPRNMLNAAKLCGPRGIIALQEHFKDFRFRGKGYELADLDSMMRRYEHWAHRLYPKYHFDDCVATIEKLGNKKIVQAYMNKYRTGLLQQEIDEAAANRSDDNDDGDEGVVQHRLNLPLDPLDSMLDEQIAISRGRTSFGNTSGIADLSMDTTFDTIRKEKGLQQGNSSVRPKDVPPESSVSVSDELMAKIEENRKRALEIRKARQLAQSQEVTGKENVEAVSGENDGSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR85</accession>
    <name>A0A084WR85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP002692-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00020991</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025991">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525404">
        <property type="protein sequence ID" value="KFB52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WR85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020991-RA">
        <property type="protein sequence ID" value="ASIC020991-PA"/>
        <property type="gene ID" value="ASIC020991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020991"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010188"/>
    <dbReference type="OMA" id="RVQAFWH"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="143"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="711"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1572" mass="178160" checksum="B0E164BA9DAD1BFD" modified="2014-10-29" version="1">MATDICLEFVDSVTYTGELHATRTSDQEEGKCGILERNRLVWYARGSLLEVFRNNSEFKVIHWCFDDCTKRARNPKSCTVECVEEIVAFGKLLLAVGLRLGPEQTQIVLLAPGGYYEVGSINLQEAVKIIRFIDPSSCSIGLLKQYSGCLAVGTVDGKFILVDLCLKLVEKGNIGSKIAMNGDATKQCHIEFSRGDPKQLARNHATLRERGLYFGLQFSHDVNASVECILDIPPLKATCVGFADGTVIIVDLVDQSLMHRIASPTDDCPVAAMNYLEPSDDPEACLYLWVFYEHPEGAFATLYMIMCEEKYMQDELSVYDQFQSCSVRFNLPSYDAGSIPLHVQSITERIGDEELVTLSVLSWLGSDQTTTTVLVFDLNQWYKAEMPFECDWQDELTYLVAFQLKESSICARLDEGSFRPFHSAHRPEEHFYPNSLEFDVINYNGFNRTRHHWVGLQRKLLRYLNLDGANGVLEPSDLYQALNRAALMPLFCDPLPCEDISTKDQREFVLSLGLEYQCYTFLQSCASLWADGSHLGSDPVHGVSLSTLTDWIWNRSAVLKEVSNKMLAPLLDSSGPRMDSHTSGNLSRCTEQMKRLAKFYATILSDCKKIIPKNVMEKLTKECSSIAVAAKYLDVVLWLLLLEVLPEVPESAMDASDKDSDDGTSQHGEALRVPYPYTKLSEFYRNRRSSTLQSEVDAGSFDASVGCKNLLYIDNLIEREFDTDSIRKVWFDDEDFANTAAPLYPPESLQKALRVLLIPETAMQQKLVLLSYLFMDIVAVLDSERYADIFKEWKNFPSIFNLSPAAVQRVQAFWHLDHGDVETSVKQFLTPASNRDDYPKWHRELAVSTLLHLNAPKHALLLLRSQGYHISPQLELATLRGQPQPDGMVWFVETVLNEGKPKALLEFDYTEEEKFVLRSYLRDAPVPRCDSLLFGHLLDHAEFVEAVQHVDRLTRKRNSGMEPYRDILSLYHKSLDPTSQRLAYLTYTEPKELEPRLATPTATGDIPSVDSLSARLIRNRADFRVRILHQSIVAVKEAAEASGLLHDRPFLDKPDLGMFHRRPMVHSRNVSYPVMVEEHRPKNKRQRQECDASYDDGKYEDRWQKRRPLFEEDICANPCKRRNLGSDYNAPTTTTGMERKYLSFDTPVPVIPQFRPMVPKFNFSVPSSLMSTEIGEGDDGESGKSTSHSPSIFLQTPPLFKKKEPEFSVPEDADTFTPPGILKSSQSSQGIAADSSEEKVLRFDLPPGVTVDSSYIDETTEAEDVQGTEVIESMLKPEARPKTPQRRDLDLSGISNEDFYSPEVTMDDNSLQQLLSSGGPSRRRALHDRTATPTGPGGPSHTENIAIIIEDQVDEECLKTSEFGYRQDAEYQEEEEYTPMDVDDEKETSLEENYMXXXXXXXQRWMRRTKTRTTEQVNTAKHCVFRTLTQNCPSSTVTGAAVPCKNLLYIDNLIEREFDTDSIRKVWFDDEDFANTAAPLYPPESLQKALRVLLIPETAMQQKLVLLSYLFMDIVAVLDSERYADIFKEWKNFPSIFNLSPAAVQRVQAFWHLDHGDVEINLTALKKLTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRW8</accession>
    <name>A0A084WRW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Casein kinase I isoform gamma-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021298</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRW8"/>
    <dbReference type="STRING" id="74873.A0A084WRW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021298-RA">
        <property type="protein sequence ID" value="ASIC021298-PA"/>
        <property type="gene ID" value="ASIC021298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021298"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760051" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021298-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8880" checksum="939CFB15B811F715" modified="2014-10-29" version="1">MASWIRAFNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWTCNWASDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSE7</accession>
    <name>A0A084WSE7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fuseless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021526-RA">
        <property type="protein sequence ID" value="ASIC021526-PA"/>
        <property type="gene ID" value="ASIC021526"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021526"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021319"/>
    <dbReference type="OMA" id="NADKHRI"/>
    <dbReference type="OrthoDB" id="45313at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070073">
        <property type="term" value="P:clustering of voltage-gated calcium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007270">
        <property type="term" value="P:neuron-neuron synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032751">
        <property type="entry name" value="Fuseless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270:SF2">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15993">
        <property type="entry name" value="Fuseless"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77774" checksum="1A3D1B22CE080D4C" modified="2014-10-29" version="1">MRGSFLRLDQLTGGSRKSFDDGPHVPDIVNNIYAALVIGPLVVGYWRGTWNLMDSLLFPHDELCRMTALLMFGLGGHLLFMLLQGKLQQWLDVDEHPVAFYLWSRVYTYVYGAMCVSTWRGGWILIDHYAPPNLLFFIEASLVVLLLLASVQAFCNVAGAPFVNDSPNGYFSVPTYFKSKEGPDTGRSLLLQLSRTGHSHAQTSRCDAAPAPAPDHQMLWEGGGMLDVRIRRGTTSDTRGGKTPPGNVSMRGSIAGIEDGIVGARVGANYHGLLLELIDYLYASLVVAPLVVCYWRGTWNLMGDYIFPSDLTTSLIVSLVIGIVGHIVFNIFQATIRRHLNADKHRIAYYVGSRMYTAIYGVICVNGWRGGWQLIDLYTTHDVLYVVLITLGCIFILACLKGVRNVMGTPFLIINDSRREYFDVPTYFKLTGSKDPGLYVLDCMFSVLVIGSLVVFVWRGLWVLLDQKLFPHDQGTSAWASVIIGYGVTGLTFSLQPLMRWTCDRLTGFWRVVVADFFLFFSFIGTINVWRGIWQALDTYFLPDEKLLSNWITHAVSLLLLILLNCSNSVLVRGVYIDAEEPAGQCVVFPVYYIRLFFQKERKKKQRRLFEALERADLNSTGGVVQDKKLPHHPHFHQQQQQQQQQHQKQEHHIVADQNHQVIRNLEAVPLTIIDDPKSNGDHSSHVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSW5</accession>
    <name>A0A084WSW5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L46, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00021616</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026739">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525418">
        <property type="protein sequence ID" value="KFB53309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSW5"/>
    <dbReference type="STRING" id="74873.A0A084WSW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021616-RA">
        <property type="protein sequence ID" value="ASIC021616-PA"/>
        <property type="gene ID" value="ASIC021616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021616"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003009"/>
    <dbReference type="OMA" id="EKWDLYA"/>
    <dbReference type="OrthoDB" id="194611at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB53309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="23437" checksum="F0E87A0D0C6C3BB1" modified="2014-10-29" version="1">MLDQIELEKSLKSNHELRKETEKRQLELLKAGKIDLDSEALKQTAQDLEDAYNDELAKFNPAPRTTEADKKNNIRSLDRKLEETLVLLVEQKLGNKSHFLLPQGRHKAGESMRQTAERTLKEQCGDALQVTFYGNAPVGFYKYKYPASSRTETVGAKVFFFRSVLKQGSGNIADSKLKYQWMSQKELQQQLQQAYYQSVAQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSW8</accession>
    <name>A0A084WSW8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00021620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026739">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525418">
        <property type="protein sequence ID" value="KFB53312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021620-RA">
        <property type="protein sequence ID" value="ASIC021620-PA"/>
        <property type="gene ID" value="ASIC021620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021620"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015990"/>
    <dbReference type="OMA" id="IYQPRYM"/>
    <dbReference type="OrthoDB" id="6514304at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638:SF3">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="192" mass="19960" checksum="8EA70E3F4E8E6C7A" modified="2014-10-29" version="1">MNGQVSSSITGGFNCSHLANRGLTPLQMPAQAQLPPSYNSVMTSMAPTYQPYPPGIVPQPFYGNASWSVNPSPQAQFAPPPPPYAATPGTVTAIPAQTVHHQPMYQYQIAAAPPPNQPGQLYQTPVYPVQGAMFDAGARFGKSGGQPTIPPPPPGLAPNGAQLASMQGQQVVLAKKKSSFLGGGGGAGYTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTU8</accession>
    <name>A0A084WTU8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cycloidea-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021885</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026916">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021885-RA">
        <property type="protein sequence ID" value="ASIC021885-PA"/>
        <property type="gene ID" value="ASIC021885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021885"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021885-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13208" checksum="2D1FF5C38915D499" modified="2014-10-29" version="1">MPKVEDTLSKEKSPKTRTEKPAKSRNATRTGAKQWSCCALRDPIVTEPTVCQHVAAGCIEPAQGTTRRTPNGRWQYVHSHTRQAPNNYSHADADPRVHLYVLSGTILESMAERRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTY9</accession>
    <name>A0A084WTY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00022004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022004-RA">
        <property type="protein sequence ID" value="ASIC022004-PA"/>
        <property type="gene ID" value="ASIC022004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022004"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004322"/>
    <dbReference type="OMA" id="YCNETFR"/>
    <dbReference type="OrthoDB" id="7755117at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB53683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022004-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19867" checksum="4ABF815482E95C1A" modified="2014-10-29" version="1">MSETQFVCELCQQHYSTFEILMTHNRLKHYHTIKFGCGYCNETFRSEDDLYCHFVLTHHIDPCGNPTSGERVHRRSHTNSEASDECEDQPCGQLRLISESDDGSLIESSSAEGEFDEDEDCSCSEEESDAELNYNELYVRRKQSAMTQEEISELTDVFKKTVQATYTTKSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAK5</accession>
    <name>A0A084VAK5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00000815</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01004128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAK5"/>
    <dbReference type="STRING" id="74873.A0A084VAK5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000815-RA">
        <property type="protein sequence ID" value="ASIC000815-PA"/>
        <property type="gene ID" value="ASIC000815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000815"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010250"/>
    <dbReference type="OMA" id="WIGFGQA"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF116">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000815-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="267" mass="31813" checksum="478C7C5062503DCF" modified="2014-10-29" version="1">MALVLQRVYDVYQEFLIDRRDMRSAHLPLAGSPWPLATLLATYLYVVLYAGPRFMAHRKPFDLRNVIRVYNIVQVLINSVIFTWIVVKIFIVYKDYNYSCQVCHYSSDARGMEEMYLSYSYFMLKVLDLADTIFFVLRKKQSHVSFLHVYHHTIMATGSYFGLLYVPGGHAIMLGIWNTLVHAVMYFYYFLSSFGSQYSEWWKKHLTRMQLLQFIHLAFHFGIPLFFNHECKFPRVWLVIGFLQAIFILALFMDFYIKSYIVKRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAV8</accession>
    <name>A0A084VAV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000984</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524215">
        <property type="protein sequence ID" value="KFB35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000984-RA">
        <property type="protein sequence ID" value="ASIC000984-PA"/>
        <property type="gene ID" value="ASIC000984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000984"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000984-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="23880" checksum="08DC7B11E25A0420" modified="2014-10-29" version="1">MPLCSDLASSIFSPALWQVCVCVWSGQRKCFTLRRHLIAPSLGDRRGGTVPLKPVENQRAVRAENANEDVIRVLAIDLRFHQETPSPTKRLCTWVPPVVFSSCNITIAIITVIPGVRSVGKKIDHNGQVPRHMDRLGNGARSENAARVAAKCRLVTDHCLADRQLTSTRRALPRKCNWMKRVREHARCESRASLTLAFPRPGCKSATGTKQVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB82</accession>
    <name>A0A084VB82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00001352</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01006060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524335">
        <property type="protein sequence ID" value="KFB35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB82"/>
    <dbReference type="STRING" id="74873.A0A084VB82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001352-RA">
        <property type="protein sequence ID" value="ASIC001352-PA"/>
        <property type="gene ID" value="ASIC001352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001352"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009189"/>
    <dbReference type="OMA" id="RIADIKC"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="46"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="33762" checksum="FB170EAAC1BD73C9" modified="2014-10-29" version="1">MKISFPLVCEEYRKITVKKQTVLPLAFFAKPIELESNNCTNVVQLIAGGEPARKGEFPHHALLGFIKHGTYSDYEFKCGGTLISNQHVLTAAHCFKENIPKVVRLGAYSLLESYDAYDVDIEGFLQHPSYKPQKVHHDIALVKLANRVFFTSLIRPACLWDTEQRNISRYIATGFGSNESFSLVQSTELRKVQLEEFPIEDCVRIFIINPRFRDDTNEGKICVGSNVVGRDTCQGDSGGPLQTVTSPTTCTFHIVGITATGGVCAIGNGKAMYTKVSHYIDWIEKNVWGPNPEAYTVVGHKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBE2</accession>
    <name>A0A084VBE2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00001508</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01006574">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524368">
        <property type="protein sequence ID" value="KFB35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBE2"/>
    <dbReference type="STRING" id="74873.A0A084VBE2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001508-RA">
        <property type="protein sequence ID" value="ASIC001508-PA"/>
        <property type="gene ID" value="ASIC001508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001508"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004844"/>
    <dbReference type="OMA" id="NFQWPPI"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="188" mass="21334" checksum="768466AE486DC789" modified="2014-10-29" version="1">MARSTTIKDALKRWQEDHDGQNPIEAEDIQLQFRWPPIERMDGTLGTLVNCQKLSLSSNMIEKITGLNGMKNLRILALGRNYIKSFNGLEAVGDTLEELWISYNQIDKLKGVESLRKLKVLYMANNTVRDWAELARLQAIAGTLEDLVFAGNPLVENLDEAVYFREVTKRLPTLKKLDGIPMLTDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBX6</accession>
    <name>A0A084VBX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glutamyl-tRNA amidotransferase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002212</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009808">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524547">
        <property type="protein sequence ID" value="KFB35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002212-RA">
        <property type="protein sequence ID" value="ASIC002212-PA"/>
        <property type="gene ID" value="ASIC002212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002212"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9403" checksum="FC30BB37968A5562" modified="2014-10-29" version="1">MTFGELAAHANESGMDWEHVHGKQQNIDESNNRMHRRDGKWPPATSKPIGSETYLRPDLGQDLVGCLVGAVVDLTLGSVWTRVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC84</accession>
    <name>A0A084VC84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP005599-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00002447</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010625">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524589">
        <property type="protein sequence ID" value="KFB35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC84"/>
    <dbReference type="STRING" id="74873.A0A084VC84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002447-RA">
        <property type="protein sequence ID" value="ASIC002447-PA"/>
        <property type="gene ID" value="ASIC002447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002447"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000310"/>
    <dbReference type="OrthoDB" id="8173437at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000021">
        <property type="entry name" value="glutamate-gated chloride channel isoform X12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="335"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="533"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="767" mass="84738" checksum="B05453C7F9CABA82" modified="2014-10-29" version="1">MGYQCESAHPQHRPVRSDRNEHWSAEQHLQLLDFGPGQNSSLREPRPLVSQTATATINHQPQHQPATSGSESAPRPSRTTSKHCLRGGKEATPAVEETGRKVAGTAKKRRRSCSSSALRRPSCSFLHPTTTAVLDSYASLVLNKLSQFISHHVGSAREGNATKGAGVGPNLPANLPCSITRETSPRPSKAARHQREQSPNRLFRSRRTRNPAQSIAGLSALQSDEEKVLVAAPDLQAPRHDARATNPSREEHLHVPVREHRDAPFQSVAKPTSSHHLLSLIFAEGKSDKEILDHLLKNSRYDKRLLPPVDDADFCCGMHTPEMAKHIPDMRVPGRPQNRGTLTVNVSVLLLSLASPDESSLKYEVEFLLQQQWFDPRLRYANQSQYEYLNAIHHHEDIWLPDTYFIMHGDFKDPIIPMHFALRIYRNGTINYLMRRHLILSCQGRLNIFPFDDPLCSFALESISYEQSAITYVWKNDEDTLRKSPSLTTLNAYLIQNQTIACPIKASWRGNYSCLKVDLIFTRDRAFYFTTVFIPGIILVTSSFITFWLEWNAVPARSMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVVYRPGENPVTQRLPAVLSRIGIILASPLQETIDREFHTAIAAEKTTAATAASATAAAAASAASGSVAQVPSRANLRPPPTAPVVATSGAPLGATASGPGGMRPAQSSVVMCEAGLEGPAEVGITRRRPTVETKLNEIGLMETSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCP1</accession>
    <name>A0A084VCP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008687-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCP1"/>
    <dbReference type="STRING" id="74873.A0A084VCP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002636-RA">
        <property type="protein sequence ID" value="ASIC002636-PA"/>
        <property type="gene ID" value="ASIC002636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002636"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018572"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000043">
        <property type="entry name" value="AGAP008687-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="46560" checksum="89954943339B4802" modified="2014-10-29" version="1">MSASGMLYGGDEIGALVFDPGHHSLRVGYAQEDTPKADIPSVVGVGPADPIINSDLETKADNNIGSTNKYYVDTTLINVARPNMEIQSYMKDGMIENWDLFEKVVDHVYAKVVQSESMYHPVLFSEAAWNVRNNRERLTELMFEKYNVPAFFLVKNAVLAAFANGRATALVVDSGATHTSAVPVHEGYVLSQAVVKSPLGGDYLSLQCRHFLEGQNIDLTPTYAIAAKDVIKERDTPRFTAKVLPEKLTASWQQYMQKGLLQDFQMSAVQVLETPYDERTAAQIPAVHYEFPTGYHQDFGPERFKLAESLFDHNMLGAGQLASASVGMCDADVRLSLYGSVVVTGGNSLLPGFAERLNRDLQHRAPSNTRLKMISANGSVERRFGAWIGGSILASIGTFQQMWISSQEYEESGKSQVERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDL1</accession>
    <name>A0A084VDL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003084</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011626">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003084-RA">
        <property type="protein sequence ID" value="ASIC003084-PA"/>
        <property type="gene ID" value="ASIC003084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003084"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="9409" checksum="6AB10B4E81B1F8A3" modified="2014-10-29" version="1">MGAIKLQWRIEIIVTVCVFTVFMGESEIFTIFPRCLLPSGSHFWHFRSNTGGFFSQSLLFLINPKKIPPNMIGKCEETADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE07</accession>
    <name>A0A084VE07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP002236-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00003292</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524753">
        <property type="protein sequence ID" value="KFB36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE07"/>
    <dbReference type="STRING" id="74873.A0A084VE07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003292-RA">
        <property type="protein sequence ID" value="ASIC003292-PA"/>
        <property type="gene ID" value="ASIC003292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003292"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="463" mass="50390" checksum="91DD4CEB43FEAD35" modified="2014-10-29" version="1">METGQEPKEPEQNPGPDMTQPNLHQAHPHHPSSVAVSQASQPLGPEVPVDEMIVTSEMHSSAERNSPGQQQTAEAGLGAGSANGGAETTLIPVQTQTIFVEYKNEGEEAVRYVNRYEDVKYHPHSRYIYQQPHAGLPLPSTLHSSGGHPHVAHHPHHPHHPHHPGHHGHGGMGPPGHQVHHHAHPQSSQQLPQHSSGVALTTQAGATVQVQTQPSHQTIQVYETHEASGGPGEVQQVAEGTVVDAKTHYTNLEPVHTLASPQNYYIASDGYSTGNYTTFLPQKEAIYYHPASPNTVLYKGDPTLTSSSIITKQIHYTPPIGNSQNMYENATGHSSSSPGAQQIYSGYWNSASVDYNTNFTGTIVMDNAGGNVGEYTTNGQHWQISSLNEAYDPQLATPTEHRECVNCGSSDTPLWRRDVVGHTLCNACALYSRQNPGTNRPPNRSQKAKQAVLYIYGHRKQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF15</accession>
    <name>A0A084VF15_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Alkaline shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003748</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003748-RA">
        <property type="protein sequence ID" value="ASIC003748-PA"/>
        <property type="gene ID" value="ASIC003748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003748"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="18025" checksum="2B2AE60B4C210AA0" modified="2014-10-29" version="1">MLPITSLLRSILNSSISTYVLLTVSQQPYGFMAWVLLEHRVFADLAENAQSYGSRRAKAPSMVAVVKRRTSTQEISTAASKSDQCSPYRRTRNTFAKRLEEVLPVKTQQKCSLKRNEQEEALLLRVYGLVDLPWGLEVSLGLSSARQQIVLVPSIGLCRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFC0</accession>
    <name>A0A084VFC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007637-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003723</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFC0"/>
    <dbReference type="STRING" id="74873.A0A084VFC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003723-RA">
        <property type="protein sequence ID" value="ASIC003723-PA"/>
        <property type="gene ID" value="ASIC003723"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003723"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007405"/>
    <dbReference type="OMA" id="CMVPIGK"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003723-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="538" mass="62907" checksum="3C31038C242285C1" modified="2014-10-29" version="1">MAMDQQQIYNQAYGEALRTNANETQRWSAYRQEHLDLKENLRMYQKTPRADILIPMGTKALLPGQLYHTGEVLVSHGGGYFTECSSEQAQTIADRRVKLADEMLQKYDRERTLYSDKLEMPFLNEAFAEGGREIIEPYDEQTEERWRAEHRRRVRESKQREAVDRKAKDQDDRELFEKLEEMELLEELENEMDQLEMPEGNDDQLERLMRGEIRLNSKPRTAHRSVPPTESDAICIRKPIEERPMGGERITTTKDEKNGKSSDEEIVTTDDESVDGQDEEDISPEFSQLLNDTKTLAKDEKIKIFQTKLKDVRKRLYQNSITITEKVDLYQLYEELEEALDFLRTGQETDGAIDEEVEEPKSDQEPTSNNETEKHTKKQSRKISFAEHDEIKLIENRHSLKVTEKLPSANTERTVFVPIVHSAETLSNEYRDEAQEDEIICPADIFRKEMERRETPLEIRSILKNKHFVEKESRSAFESFSKTNVKRPVKEMRTENTMPDDILGEIVEHKMEAESTSAVSELTPQPKKKVSRFKQQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFE3</accession>
    <name>A0A084VFE3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dvir\GJ16097-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003834</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012381">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524786">
        <property type="protein sequence ID" value="KFB36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003834-RA">
        <property type="protein sequence ID" value="ASIC003834-PA"/>
        <property type="gene ID" value="ASIC003834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003834"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003834-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21896" checksum="6B835220BE73D75F" modified="2014-10-29" version="1">MLSSFISGSASPTLSVPQLPSTQRQDEERTLDITVRGLATRCHHDGRGEISRPDDVTNLSPCAPERIVVACSLRDKDLVSPKPSPFRAHHHRNSRPARKSYAYVTRRSLTLGLYARRPAEKRWFGVNMLLIGIKSRRSYERPPARSLTGTANRKDSEWQRESNKREHPPFCQHLHRAECWSISVQFRVFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFP3</accession>
    <name>A0A084VFP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001531-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00003947</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFP3"/>
    <dbReference type="STRING" id="74873.A0A084VFP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003947-RA">
        <property type="protein sequence ID" value="ASIC003947-PA"/>
        <property type="gene ID" value="ASIC003947"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003947"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003363"/>
    <dbReference type="OMA" id="TAWEASH"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="562"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003947-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="619" mass="66156" checksum="3C075DEF5C635BE1" modified="2014-10-29" version="1">MVHEEEELRYLRDDTQTRSATINPTGRSGKAVPLSLPDSDVNSESWIRRGLHFCSPTRRLPILSWIRRYDGEDFISDLIAGITLGLTMIPQSIAYATIAGLPTQYGLYAAFMGSLVYVFFGTVKEVSIGPTSLMSLLTLQYTAGRPPGYVIVLAFASGLVELAMGVFRLGFLVCFISAPVTSAFTSATALIIIGVQLRNLLGIPRPANGDGGFFGTVLNVLGGLGEAKLGDTALGVGCIVLLVALQQLPKCAPARGNPFLRRTLWYVSLARNALVVLASAVLAYHLAASSADGSVPFRLSGNVEPGLPSFEWPVRGVTVGNTTVPFLEVTAQLGSGLLLVPLVAVLANVAIAKAFASETVVDATQELLALGLCNLVGSCFRAMPTTGAFTRSAVSQASGVRTPLSGLYSALLTLLALGVLTPYFYYIPRATLAAVLIAAVTSMVDFGIVRRLPRPPRHSPADLLSWALCFTVCLLLGVELGLLCGMAVSLLEPLRHSVLPRADCTTETDPTTDTRYRRIRPRNVPALLYPGIDRLRKLVLAETHRQLTEASGTPGGTVPLPLVLDCERLVALDFSSARALRELTQQVHQLGGTLYLRDVPAAWRSSLQLTETAYGLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFY7</accession>
    <name>A0A084VFY7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004085</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012578">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFY7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004085-RA">
        <property type="protein sequence ID" value="ASIC004085-PA"/>
        <property type="gene ID" value="ASIC004085"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004085"/>
    <dbReference type="OMA" id="CRSIDYE"/>
    <dbReference type="OrthoDB" id="8033674at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004085-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9168" checksum="EAC659C283D90431" modified="2014-10-29" version="1">MRRMTASVSGVDALCRSIDYEPVRVPPLATASLTASLTIPTECIVLSVADEPSPEVQKVEPVTTSALPFRRDGRAIHPKPFRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIE4</accession>
    <name>A0A084VIE4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial brown fat uncoupling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00005051</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIE4"/>
    <dbReference type="STRING" id="74873.A0A084VIE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005051-RA">
        <property type="protein sequence ID" value="ASIC005051-PA"/>
        <property type="gene ID" value="ASIC005051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005051"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015767"/>
    <dbReference type="OMA" id="HARRYCS"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000008">
        <property type="entry name" value="Mitochondrial uncoupling protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="241"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36268" checksum="8BD7BD394BD19665" modified="2014-10-29" version="1">MSFQRRTSEKTTELTASVPVKLLTAGTAACFADFITFPLDTAKVRLQIQGEQPVRTVAMTPAVNTTASFKLNPTPLPATQHVQYRGLVGTITTITRQEGFRTLYNGLSAGLQRQLCFCSIRLGLYDTVKTFYGSLLKENEAGLQIGTRILAGLTTGGAAVMIAQPTDVVKVRFQAATRSSTGRRYASTLEAYRTIGREEGVRGLWKGAMPNVGRNAIVNVAEIVCYDVVKDCLLLYTHMPNDIRLHFSAAVVAGLAATIVASPVDVVKTRYMNSPRGQYRGAIDCAIRMGAKEGMNAFYKGFVPSFARLVSWNVVMWISYEQLKLVVFNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VII9</accession>
    <name>A0A084VII9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper transport protein ATOX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Metal transport protein ATX1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00005100</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with ATP7B. Interacts with ATP7A. Interacts (via dimer form) with SLC31A1 (via C-terminal domain); this interaction improves ATOX1 stability and controls intracellular Cu(I) levels.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VII9"/>
    <dbReference type="STRING" id="74873.A0A084VII9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005100-RA">
        <property type="protein sequence ID" value="ASIC005100-PA"/>
        <property type="gene ID" value="ASIC005100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005100"/>
    <dbReference type="OMA" id="YEFDIAM"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005100-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8077" checksum="81BF3983A9EA0EC0" modified="2014-10-29" version="1">MASTAVHEFKVEMTCTGCSGAVERVLGKLKEKVDKVEIDLDNKKVFVTSALSADELLETIKKTGKETSYVGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKA6</accession>
    <name>A0A084VKA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005759</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005759-RA">
        <property type="protein sequence ID" value="ASIC005759-PA"/>
        <property type="gene ID" value="ASIC005759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="8417" checksum="E34F0B0C8B6A502C" modified="2014-10-29" version="1">MVTTRENKMEQPSLLAQCTAYTATATFSRSSSTSAAAPAMAATKQAATFSAAAPTAMATTMGSGSATGAGDAAAGPLPLAFPGLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKM5</accession>
    <name>A0A084VKM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005927</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKM5"/>
    <dbReference type="STRING" id="74873.A0A084VKM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005927-RA">
        <property type="protein sequence ID" value="ASIC005927-PA"/>
        <property type="gene ID" value="ASIC005927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005927"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016997"/>
    <dbReference type="OMA" id="ENEATSM"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="112"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005927-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="326" mass="37929" checksum="820CF48E5EE8674A" modified="2014-10-29" version="1">MLNRLEKNDNERIEKVGTKHETSMKAMEHSLKNTLETIEIKTHDEMADLKNQISLNISHIRQNQVAQIKSYQETSQIELKKLGEHTKSLDMISDSVRNMVTLSEQCNKILEAVSLYPVHSCRNMRKQSGQYMIQIAENADPFKVLCEQAKFDGGWTVIQHRFDGSVDFYRGWSEYRYGFGNLDGEFWLGLEYVHQLTKNRPHELLVEIKDFHGSYGYAKYDEFEIGSETEEYELKKLGTYSGTAGHSLVDNKGKKFSTFDRDNDLSGHNCAADLHGAWWYWSCTYTNLNGRYQNTTNEWSALTWSGFKDDWRGMSYSRMMIRDIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMU5</accession>
    <name>A0A084VMU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006642</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006642-RA">
        <property type="protein sequence ID" value="ASIC006642-PA"/>
        <property type="gene ID" value="ASIC006642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006642"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5540" checksum="BA3AA45051E8094A" modified="2014-10-29" version="1">MPSESKCIIGQLERLENLALMHFPSRFSGCESEDMVNPPDASRRQMVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN19</accession>
    <name>A0A084VN19_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000955-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006786</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC006786-RA">
        <property type="protein sequence ID" value="ASIC006786-PA"/>
        <property type="gene ID" value="ASIC006786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002439"/>
    <dbReference type="OMA" id="KPCHIMA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
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        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="472" mass="52858" checksum="352041DEF2318A03" modified="2014-10-29" version="1">MNFDELEYFSYKINHQWTRDLRHQFSIPKQCCILKCNKIKVLALCDRLRRMCLRVYEVYPTCQSTDREHLLRRVARQPIPSALFSGFTVFPSDLFLFPVFFRSRATGVKPPSREANASNDGGHAGRYDVVFQVLILCFQAKAWHAVRRSFELEQSTPLQEKNHLVTDCMHVTSEEGEFSFVKLPATRSTSKHGHWSMDGDLSAALNADGSAEGLSAESPDAATVCGIYFVTDPDQLIEVTMRQVNVDCRSGGLMAFVDGWELNGQYFPGERDHEKPLALRVQEFCAERGDAGPWPAGKHAPAQGAWVFRSSQNAALVQYRIPTRGSFVLSARFLRNPKPCHIMAEGLAPYYMLRNYGQRRNCTLTALFPAVVSVVALEVGGINENVRYCERIRVEDKLEVGGSPGLDPANQAVRASTICGRSGGRMDLEQTILCGTTTVRLVSSGRYNNQAMVTMRMVDESDLRLATAMCEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNH8</accession>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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    <dbReference type="Proteomes" id="UP000030765">
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            <begin position="1"/>
            <end position="23"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KFB39522.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNT9</accession>
    <name>A0A084VNT9_ANOSI</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">ZHAS_00007126</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Mosquito</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ASIC007126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007126"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB39633.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007126-PA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8254" checksum="F8238FC2F2B54E26" modified="2014-10-29" version="1">MPKISKYVRAPKYDSEEGSEGDSNGDVVRLVRPIVPDSDQETKELRRKVLELENTIADLAGGVRNTLVGIEALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP53</accession>
    <name>A0A084VP53_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007888-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007441</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB39747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VP53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007441-RA">
        <property type="protein sequence ID" value="ASIC007441-PA"/>
        <property type="gene ID" value="ASIC007441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007441"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006851"/>
    <dbReference type="OMA" id="YFMNLSE"/>
    <dbReference type="OrthoDB" id="5799458at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1066"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="574"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="956"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB39747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1358" mass="150479" checksum="6317A41CBD42CD21" modified="2014-10-29" version="1">MFWLFVDSDHQLQQQQHQQEQQSAISSPSIGSTCSSEQTTLTGTNGSGSSKLPSSTSGHLPTSPAFQSVAGGAILPGDESSGEGEEKLHHHRDSNASLIAQKTRKKYPSKQHQLVTTGDKEVGNGVSVDENKFANGQQNTSVLYTTVQPKTLLASGGDDGDESSDREVSPKFVVGTKKYGRRSRPREDVNGFDRLSQSSNSDNESVAALNTSTNTDAASVNILPSVDACGGTKVQRSASQSDIHGSKRRRPHVGPGAIRLKRCASLPTHRQRPGTTATAASKVHPAQLQMDDERIDQKIYFMNLSENLRDIWDSLLVDCDPGRRHGDLLNQSQLQQVCERVGLQKTPARLAAQEVFSKLSLQPIEGISFTEFIALLESNTDLLPMGNENSEQQLGDCDDSGTLLSSASVGPAHEKSFTLAMPDWTSDIGSLAASIIIDMWEAAGIVAPAGLLNELGFDGDVIQVSDLVLALEEEHQRLIGGHLNTSSLSSTSSNVNDASLIVRASLALHKAEVNALRQAFHQLVEENKKLYADNKEVNNRAVLLAQEIDERHNSLENSTRTKIRHLEQRHHETVKELSSQLAFEREQLSHANAMLEKRIELLEGEESKLKAELCRVSDENEELRQEQENLTKEITDLLEKNIKLNRDIAELEENNRNDYPEDDDCGFARKDSEEVLDLIDRISLLQGENTGLRDKNDELNVEIEMLNAELSKIKLKRNSASDEASGAVGADTAAGQTAIKRRGDSPSKTRLSDESPRLGKFRKCSIDNDSEVDPCSGDWMELHSELGQSGRPSEEVSTVLSGCTETSASSGISSINDSSLARDEEIKALRSRVEELEQQLRTGKKEADSVDQGSTEKPSEPAVGAEVSAKEQECAKLKARCDELEASLEQMRKEYEDCEDYWQAKVNDERLLYEEEQRVSDEKFTELLKKVSEYEEQFAGNAKPEKDGRLSPIDEKDGLEQQYLELETDFEQAQLALEEKTHEVEKLLRRIREMEQMTKYPSEMLLSPSPHMETPEVEDRPASSPISYLWNQSTIQRPVRDYQNPNWRPPPTKASEINTVEECEKFPKSTAASETARDTDGGESDVSVSSDGGEANFVRIISPIQKPASANSGGESSVGTRDEYPADNVKPSVGVVAGLEQLEVSDTCSVKSVRSTHSLASTHSIQNSECAGMTVPVSAEHMKHLRLVQQQLQGEITDLTHERDCLLMELQQLKEAKPIIARAYTKTASHPNQMQKIQNLEQKNRHLQSMIKQQQQYTESVLHQIWQQQRGEINELRNRLEAQCIVISDQATRLASNDILVKDMYEENSRLMLQVKRLEHQCLRATWLNQMNQAPSSSPAPSTNHHSQGLSGIMPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPN1</accession>
    <name>A0A084VPN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007306</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007306-RA">
        <property type="protein sequence ID" value="ASIC007306-PA"/>
        <property type="gene ID" value="ASIC007306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007306"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12352" checksum="31232312481ED4FE" modified="2014-10-29" version="1">MAIRSPAYRRSVCRTHNWNPSHRHTTPSIPVRPISSGPRSDRSSLEEDSFAYSGYRHSSDSTAGEGSEEGPLPGGKLCEVGRFDVHRPQNMFALAERRVHQAYVNGVFPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPW3</accession>
    <name>A0A084VPW3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007397</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01015048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB40007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPW3"/>
    <dbReference type="STRING" id="74873.A0A084VPW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007397-RA">
        <property type="protein sequence ID" value="ASIC007397-PA"/>
        <property type="gene ID" value="ASIC007397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007397"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006120"/>
    <dbReference type="OMA" id="SKCTIQP"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF53">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="273" mass="30724" checksum="45BC9CE133E42993" modified="2014-10-29" version="1">MTTSNGELLGLAFMAFFIITLSSTARYYFKFFCFVAFSVVCAVGPVPLMLLRPRDYRNALIPAYLCVRFGKMLGASFSVRGKENINRSHGGIVLMNHQSALDLIVLAELWPIMGRSTVVAKKEVLYMFPFGTACWLWGTLFIDRQNRDSAKNVINKEAKAINEKQAKLLFFPEGTRGNGDKLLPFKKGSFHVAVESQAFIQPVVISKYHFLKSKAKIFNRGQNIIKILPEISCAGLTKDDIPALAERVQKMMQREYELLSDESLAINNISEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ11</accession>
    <name>A0A084VQ11_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00007515</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ11"/>
    <dbReference type="STRING" id="74873.A0A084VQ11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007515-RA">
        <property type="protein sequence ID" value="ASIC007515-PA"/>
        <property type="gene ID" value="ASIC007515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007515"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015498"/>
    <dbReference type="OrthoDB" id="8196708at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007515-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="625" mass="71376" checksum="0694E3A2D6862F0C" modified="2014-10-29" version="1">MIILFRRYPWLKQTNIHGIKSFVDRSRKPEVLCVLMEMEGELDIVKLKAEFLHHIGDCSSAHMRLCLPQFILPFVSCWNKYSWLKGTSSANEHIILTPAIQRGRPVQELMCLINNTSANCTSSGEEPLITKSKLALPWQIVCIPVIGGSNERNEKCIISNYLLYTIDLELLSEAEKRNLNYIPSNGYLERSRPLFDNLLDKPYYIPRLWNYIFSSIQQRWNEFVYQHDPLESPDYDHRKYSGIGQLLSAVFISIVYVFGDFCSSFRTLKENPLDKIDYLQRLIEREIDKRNLTIRTIWATFLLSIEPVNLLKECIFLLWKIVATFTLMVPWYTLRETEAKDKDSERQFRWKHCALTQLRLQLPIVICALGRLYSKQNVIEALLDKEKMPESCSHIKSLKDIKNVNLTPNPAYDESKDDKSSPFICGLIGLEMSGQFRFVALWSCGCVFSERSLKEIKGKTCPLCQTPFTDEDIIILNGTEEDVDQMRTKMEARNARLKLEKKSKADKKSKSKEAAPTATVTSAEASGSAAASSSGLTDKKLVVPAAPKVNGEGSSKASLKPAVPNKRALISDKIGEDPVFKKSKDDYSVAKDPKASDVYKSLFTSHESEKDQKRAHWVTYNPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQD8</accession>
    <name>A0A084VQD8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007554</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQD8"/>
    <dbReference type="STRING" id="74873.A0A084VQD8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007554-RA">
        <property type="protein sequence ID" value="ASIC007554-PA"/>
        <property type="gene ID" value="ASIC007554"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007554"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004942"/>
    <dbReference type="OrthoDB" id="7739476at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB40182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007554-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="372" mass="41016" checksum="A455FAF33980C1E2" modified="2014-10-29" version="1">MFKYESHELGASRTMYGCRMPDRSPPERTIGSGFALLPSSHNTCPEYAEGSNLSPRRATPEDVFFYQRYHQQQQQHYVPHFGHSLADTGPLAPFGTPIYTQQMILRSGASTTTSEDDQSYVGRCCNADTVGHCGFESFVRGQPYGIGEKSVDIVPPDGTFGNTIVYPGYAGNVGDPSGFCDPEPTETGTTTSSTSSTVSTRSGNSCPNSPSPEDFLADVFPFSCDGHRTHPLTTSPELRRSKTDPRTVDDNTQLQQLALHSGESAVNYPPPAKNDANTPAAQANRMLPEEPQQPKKSRTAEGTSSGVPINNRKARTAFTKAQIKALEAEFAHSQYLTRLRRYEIAVALILSERQVKVWFQNRRMKMKRMCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR48</accession>
    <name>A0A084VR48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative bifunctional transcriptional activator/DNA repair enzyme AlkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007921</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007921-RA">
        <property type="protein sequence ID" value="ASIC007921-PA"/>
        <property type="gene ID" value="ASIC007921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007921"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6379" checksum="85F4F6EE377BA97B" modified="2014-10-29" version="1">MRPVIDHTLSQVSFCRGWEILKSFDRLIAARYRLCPGGALERRDGVKNFSIPTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRW1</accession>
    <name>A0A084VRW1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008326</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRW1"/>
    <dbReference type="STRING" id="74873.A0A084VRW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008326-RA">
        <property type="protein sequence ID" value="ASIC008326-PA"/>
        <property type="gene ID" value="ASIC008326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008326"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009752"/>
    <dbReference type="OMA" id="IRTWILP"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="437" mass="48739" checksum="2976CBE6D4949D6C" modified="2014-10-29" version="1">MTEPTGEFEESDVAGPDVLENNCDDTEQPPTEQDAPMQTEELQSETGCFLRSEDEFFKDAACIEVARCSWDRATRQNYLQGCRWSPDGTCVLAAVNNDGMHIVELPTDLYGKDDVSEDRPVDILSSAVHVPEGGLVYDYAWYPGMNSTRPETCCWIASRQHEPIQLWDAFTGALRCSYKGYDQYDEVEAALSLTFSPPDGSTIYGGYKKSIKSFDLNVPGREKSTWRTKSTASCMTITSTMPDTIVFGSWNRSISVLDVRSGETLPVGNYTPENSHNAGVTWLGFAPDTEEIFVSGARKDSKILFWDVRNLQTPVRTLRRTCATNQRIWLDFSPQGQWLVSGDTRGILHAWNLREDTDAGEPKELQFPLHWDCLNGVSFHPNASIMATASGQYHFTAPTADAEDKDEPGNTAIPAKESNVENSLTLWWIGKGVFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRX5</accession>
    <name>A0A084VRX5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-dimethyl-L-lysine(36) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00008341</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01015783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VRX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008341-RA">
        <property type="protein sequence ID" value="ASIC008341-PA"/>
        <property type="gene ID" value="ASIC008341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008341"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005878"/>
    <dbReference type="OMA" id="HTHLTHY"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21783">
        <property type="entry name" value="CTD_Jhd1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15555">
        <property type="entry name" value="PHD_KDM2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000005">
        <property type="entry name" value="lysine-specific demethylase 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="195"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="18">
        <location>
            <begin position="716"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="498"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="618"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="999"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1411"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1075"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB40719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1435" mass="157926" checksum="3B7938D18F20D1CC" modified="2014-10-29" version="1">MGATAPRKKGVFFEQTLDETRAQKQLKSYFHFSRSQPPHTAVVVSHDYVPFTLIFHLCVYRERKQRKLYSEEWNLGDDDYEGARGFSVAEKLESPRFAQSGMVREMKGENLTVGFLQQNGFNIPLLFKEKTGLGLQVPSANFTIGDVRTCVGSRRVLDVMDVNTQKNVEMTMKEWEKYYEDPVKKKLLNVISLEFSHTRLENYVQSPAIVRQIDWVDVVWPKQLKESQVESTNLLNDMMYPKVQKYCLMSVKNCYTDFHVDFGGTSVWYHILRGSKVFWLIPPTEKNLQLYEKWVLSGKQSDVFFGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTDSLVFGGNFLHSFGIVKQLKIAQVEDNTKVPQKFRYPFFTEMLWYVLAKYVYTLLGHSHLVGEPGREHELVGKSHVHLTHYELFGLKDIVMYLYDLPAQKKNVPELIKDPVALIKDVRTLVERHCKDIPELAITGVPVLHPDLNVSNNSYIREHYEYYSGDGGGGGGEGNRTSTDNEGGGVGHDQDERDEEDEQRERRLHEGGKNGTDHAEDGAQHSPQQQHRQIIVKNDASSTGPQVFEASNAQEQQQQTQEQQNHSPNRHIQLAPVHRKDDAARSVIGEQRDVHHTSSSPRSPPIGSSNGGTTMGPPARLGHHQYNADDDRNFVSPQPTSGNRLPSSGGTGGRGPYKKHGLAATSGGGHGGHSGGDKRDGGGGGNGPRRRRTRCKNCEACQRSDCGECSFCLDMVKFGGPGRAKQTCMMRQCLQPMLPVTAQCIHCNLDGWRQAPITAPAQAKLQAQLQEGPSALMECSVCYEISHPDCAQRAAGGPADIHGIVNDDLPNSWECPTCCKSGKNTDYRPRHFRARQKSSDIRRMSVSSDASSVHNVDLGRIGVGGSAGVASGGGHGSGGEGGGDAVIAGANVPAPRAPRFQDDMLYDFAVSGSAVIVGGNGGNILFERKPKIKDEDISSGSENDAVGKKMMTGGPTGTMMKVEVKDEPLDQHHPQNQHHLQHHHHHQATSVIKDGREVQQQHQQQQQQQLGTVVGGAGTGVVPIKRRKSEEGGAIPVNNHNSTTAEGGSGGGGGGGGGGHEPKNNHSSSSLPRKKSSQRMQLAHQIHSTSTKPMKKPLYPIRPASTAHSGAMAQSGNYALDATCLLAVFRYLPPETLVTCTMVCKTWSNIAVDPSLWRRMNCTEYKLSPNLLSAIVRRQPEHLIMDWIALGKRQVTWLISRIPGLKNLSLQGTHIQAVLGLHSCMCPPLQVLDLSFIAGLNDFAIREILSPPKDSRPGLADSKSRLRNLKMLKVAGADISDVALRYITQGLPNLTHLDLSSCQRITDAAIAQIGTSQAAIMTLIELDLSCCKLITESSLAHLATCKALTRLDLSHVPQVSTQAVIKFATESKNNLQLHDIKLVDKRKPPPPAQQQQEPQKKDQQSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS14</accession>
    <name>A0A084VS14_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP001925-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008186</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015792">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS14"/>
    <dbReference type="STRING" id="74873.A0A084VS14"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008186-RA">
        <property type="protein sequence ID" value="ASIC008186-PA"/>
        <property type="gene ID" value="ASIC008186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008186"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024512"/>
    <dbReference type="OMA" id="PWADENV"/>
    <dbReference type="OrthoDB" id="8825892at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF2">
        <property type="entry name" value="SIDESTEP V, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="448"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="587"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="967" mass="104868" checksum="E9496A7FE66FD23B" modified="2014-10-29" version="1">MEVGFSNPTKATNYRTIAHIVSFHPLESPLIDVQTAVGLDVSLPCDLLPTTMTMMTDKVYLVIWYKEGNTKPIYSFDARGKSLQQAIHWSDEAVLKSKAYFYYDTSPPALRLKGVKQEDAGLYRCRVDFHKSPTKNCRILLDVLVPPTKITILDELGAAVANNVVGPYRESADVNLTCISSGGQPTPKVTWWREHALLDDSFLVLPDGTVKNVLYLEKLSRHDLHSVYTCQASNGHVVPPLSSAVKLDMKLPPLYVRMQGLRETLTAGVKTQVSCITAGSRPAPSVVWTKGSSVIRGSSQTTSNDGNVTVSELVFVPGPEDNEKSITCSISYNEGDGPTVLLKDTHVLNVKHVPVISLALGAPLNSQNLMEGSDVYLECDIKANPPVKKIEWFHNNKLLQSARGIIVSNQTLVLQSITKSTHGEYMCRASNSEGTVNSNQLYLDIKYPPVCKSEAQIIRAAVKQTVNITCDIDANPMPNLLFRWQFNNSLESMLELPPYTNVESEAANLALAEIDLETNNMGPSLEEMVRRKLERLEHSDESVPLVDGQLYMYRVDTFNSFGTITCTATNSYGQSGHCAYHILVADVPDPIKSCTVSNVTAYTVHISCIAGKDGGIPQQFHIDVFEESKRKLLQSISYQSAEMLLKKLPSDTKFIIKITPYNLQGTAPTSYRVKAQTLPAPLLRTAPSKAVLVQLTPLLGALVGAAVTLCLVALCIIVFVKFKTKKKHHQTANTEQDKGSAEPLSRNIGSHSSIDDKNPDVIPHENSEDDDEKQFERLVLNTESLKFTSTPASTGAAYSPTHHHLMSPTGNGFKKFGELSLTTNPGYAIYSSPVRSYAKPSAGPQLGSLLLSTAGPQGTTTTSATAGGGLLPSSTCPASATSPSSGVGGVLPTRTSPNIYTRLPLRDFTPNSYDSMLSTSQTTSCSSSSNGGYGATQIYTAKMPLLTTNYSTLDSTVGPGGLAVDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTT9</accession>
    <name>A0A084VTT9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00009005</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016489">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525092">
        <property type="protein sequence ID" value="KFB41383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTT9"/>
    <dbReference type="STRING" id="74873.A0A084VTT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009005-RA">
        <property type="protein sequence ID" value="ASIC009005-PA"/>
        <property type="gene ID" value="ASIC009005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009005"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007709"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB41383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="359" mass="40401" checksum="56DD2EAC1F36522C" modified="2014-10-29" version="1">MEAIEEILPFLSIKSRLDLKAVSLSHVLGLTGSVDGIKLLIRNETLLKHLLDLTGDESESVAKDAVLCFVNITAEESGAEVVVDKFVDRLVPLAYQAVLDENGKLSDAWCMVLCNITRPEHLAERVVAQLLTMEYSIDKLTTCFTRVNYNKQKCHLNYLGPLFSNVSQSKSGRAVFCNQSTGLLRRILPFVHHEGSIVRRGGAIGLLKNVCFDSSVHEWLLSAEMDILSFVLLPLAGPEEFDDETNDKFPVDLQYLGPDKKREEDPDVRKMLVESLAQLCATRKGREYLRDHGTYEILRELHKFECTPDGDKNVLNAVENVVDILIRTEEEIGEDNLKELEIPDDVKSKIETMNDDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTV9</accession>
    <name>A0A084VTV9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP002028-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00008987</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525092">
        <property type="protein sequence ID" value="KFB41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTV9"/>
    <dbReference type="STRING" id="74873.A0A084VTV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008987-RA">
        <property type="protein sequence ID" value="ASIC008987-PA"/>
        <property type="gene ID" value="ASIC008987"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008987"/>
    <dbReference type="OMA" id="TIKYETC"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000429">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="578"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008987-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="620" mass="67584" checksum="21074DF6A6D77BAE" modified="2014-10-29" version="1">METTGLAKGHKLMSDPRGQGGGEDPIFNASMIRVASVHVPDLLSSHIIEEFRDLPGTFGGEIPDTGMKVLADWADPADGCTEFHRKPPNNSSKYAVVIARYNCSFEVKVRNAQQAGYAMAIIHNVGSNDLEHMSASHPQDIIIPSVFVGESSGRSIIEAYTYDHDFALVITDDIPFNISNNLIIPFAIVVGLCFIIMVLFMIIRCIRERRRTLRNRLPARMLKRIGIVKFAKGMQYDTCAICLDDFVENERLRVLPCRHAYHAQCIDPWLTKNRRVCPICKRKVIVRGERLQPRRRWPSDSMSSSDADETTPLLNSANETNQPAAGVTPPAATSSSSQAPNAPTNTDNSSAGTATAVAGVIQTSPRRTAHDQLPQQQQQLQQNSAPSSHVVNVVPSDDDDELLDDRNVPNARWLGRGRPGPEQQQQPMNESPYSPIGDEATLSRWQRFKRLFTRTTVETDADEDNDADQPPSNQPQTTPASAATTAATGPALIDNSNNILNVHLAGSFHGSEDTTDDELLGAMSRDVAKRRQFRSAPDMPSTSSVVTSSGTARVGVAALPNENFNPAVQIPDYLHRITLPAGPGNGGPTRTGSRGQPRRSRNHRGRPHNGGGGGDGSHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTY2</accession>
    <name>A0A084VTY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009011</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009011-RA">
        <property type="protein sequence ID" value="ASIC009011-PA"/>
        <property type="gene ID" value="ASIC009011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009011"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8842" checksum="AE5AF5CD118B0396" modified="2014-10-29" version="1">MTLDPSNVPEGATGPIASVKLPAAIHLAMLFDVVRDMAGSPHQIIIRAHRNTSNLVPQRMKWKAICFPARNVGVKQRSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVL0</accession>
    <name>A0A084VVL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP000255-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00009581</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVL0"/>
    <dbReference type="STRING" id="74873.A0A084VVL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009581-RA">
        <property type="protein sequence ID" value="ASIC009581-PA"/>
        <property type="gene ID" value="ASIC009581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009581"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009884"/>
    <dbReference type="OMA" id="YGQFEAK"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11861">
        <property type="entry name" value="SH3_DLG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001402">
        <property type="entry name" value="Discs, large homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.470:FF:000001">
        <property type="entry name" value="Disks large 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000058">
        <property type="entry name" value="Disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000048">
        <property type="entry name" value="disks large homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000004">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016313">
        <property type="entry name" value="DLG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001741">
        <property type="entry name" value="MAGUK_DLGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="16">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="150"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="247"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="436"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="547"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="14">
        <location>
            <begin position="706"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009581-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="896" mass="99825" checksum="756385A792CCC5A1" modified="2014-10-29" version="1">MPVKKQEAHRALELLEDYHSRLSTPQDHALRSAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKTVHQKTIETLLIASKWEHDNVVKSNETNRIQQQEQPQQKQPQPQQQTHRQSQHLPEVEKQPFIELPSSELSTSKLNGNSPWEYDEISLVRGTTGLGFSIAGGTDNPHINLDASIYITKVIPGGAAHADGRLQVNDCIVAVNDVRVVNVTHGQAVDALKKAGDQVTLHIRRKKPPVQAPKLEEIELLKGNKGLGFSIAGGIGNQHIPGDNGIYVTKIMEGGAAHIDGRLAVGDKLIAVLTPTAGERNLENVVHEEAVATLKAITNRATLVVQKTNILQALANSISNLNSLSTNAMNKVGVSMVDHAGDVGNGTGESRPEGDAEFSTTRSHSPVFVLENTSSRYASSNVLETGMPIGTPKAVSSEDITRLPRTIVIRKGASGLGFNIVGGEDGQGIYVSYVLAGGAADLGGELKRGDQLLSVNGTSLTDASHEDAAQALKNAGGTVTLEVQYRPEDYNRFEQRIQELKQAVATGTGTLLRTSQKRTLYVRALFDYDPNKDDGLPTRGLQFRHGDILHVTNASDDEWWQARRVIGDDEEESIGIVPSKRRWERKQRARDRSVKFQGHASPNNNNLEKVATLDRKKKNFSFSRRFPFMKSKDEKNEDGSDQEPFMLCYTQEDANAEAEESILSYESVHRLQINYTRPVIILGPLKDRINDDLISEYPNKFGSCVPHTTRPKRDYEVDGRDYHFIASREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPISIFIKPMSIESIMEMNRRMTEEQAKKTYERTLKMEHEFGEYFTAIVQGETTEEIYGKVKNVIWSQGGPTIWVPTKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVN7</accession>
    <name>A0A084VVN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017199">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009612-RA">
        <property type="protein sequence ID" value="ASIC009612-PA"/>
        <property type="gene ID" value="ASIC009612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009612"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004964"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="100" mass="11085" checksum="5670689B061BC1D1" modified="2014-10-29" version="1">MKEEDEDGDGWQYIDGVQPANDDGQMKNGSEAPFEAEHGATGLQQCFPQPRTDDRGEGAGAETEPQYRQLVNGMSVRLYRWMQGVGIGCQRKRKLQPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVQ0</accession>
    <name>A0A084VVQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Phosphopantetheine adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009626</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009626-RA">
        <property type="protein sequence ID" value="ASIC009626-PA"/>
        <property type="gene ID" value="ASIC009626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009626"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12234" checksum="7EC1DCAFAD74A1E8" modified="2014-10-29" version="1">MSSVYPGCAGWYTPTFIPLVLHPSRLLLRRDFSGIRSRTPASGLPRRVSRNPVRKQLLVDSQHAEIKRKQLWVEWSCGVDDARQRQQAAQRSGATAKGFASALALDPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWL0</accession>
    <name>A0A084VWL0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010043</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525180">
        <property type="protein sequence ID" value="KFB42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWL0"/>
    <dbReference type="STRING" id="74873.A0A084VWL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010043-RA">
        <property type="protein sequence ID" value="ASIC010043-PA"/>
        <property type="gene ID" value="ASIC010043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010043"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018569"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="10">
        <location>
            <begin position="160"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="593" mass="68459" checksum="BBD5E1799E24994A" modified="2014-10-29" version="1">MANSTSRVPISVLLHDKASEDEEPKKKSREDWRKAKELEEARKAGTAPAAVDEEGRDINPHIPQYISSAPWYYNTAGPTLKHQRPQDDPKAHCSGIDEWYKRGVDTSKVVTKYRKGACENCGAMTHKRIDCMERPRKVGAKFSAKQIAHDEFLQPKIVSDYDGKRDRWAGYDPANHREIVEEYLKIEQAKRELRAQKLKENPDLAEEEGESDEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYDPKTRSMRDNPTPNLNPEETEFAGENFVRFSGDIKKHAQAQLFAWEAYGKGVDVHVLAEPTKLELLQKEYDKKKSQFKDEVKNKVLEQYGGEEHLVVPPKALLLAQTENYVEYSRQGKIIKGQDKPIIRSRYEEDVYINNHTTVWGSLWKNGCWGYKCCESMIKNSYCVGENGKTAAVMTVAESDPLPRTDVANESDPETVEATRAPANVLEEKDQSEEVPSNRNDSGSDSDHETTERREKSKKSKKKRKKEKRRHEREEKKLQGKTPEEKDKLQLALEVEALNQKRAEELLKQDERKRPYNSMYDVKAPTEEEIEAYMLKRRREEDPMLAFMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXE0</accession>
    <name>A0A084VXE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003233-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010363</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525206">
        <property type="protein sequence ID" value="KFB42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXE0"/>
    <dbReference type="STRING" id="74873.A0A084VXE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010363-RA">
        <property type="protein sequence ID" value="ASIC010363-PA"/>
        <property type="gene ID" value="ASIC010363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010363"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004536"/>
    <dbReference type="OMA" id="EKANDRC"/>
    <dbReference type="OrthoDB" id="7717743at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF134">
        <property type="entry name" value="LD42267P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010363-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="631" mass="71455" checksum="3FA54CB10E8EB54A" modified="2014-10-29" version="1">MEQEALERAVAEMENNEVFAMNPDNLMRAGEFDDGFFQTKAIKGFEELGVRRTLTTQKFLQSLAQKYGVCETKNLLEGRCYSNATLPCCKGTEQIKCDRSYPFRSYDGSCNNLKHPTWGRRGNPLKYPIAPCYSDSVSKPARSKSGKPLPRNRVLISDVAKVLDDTRSGLTSKMSMSTVFFSEMVNGDMIGRATKRTRKPSNGYRGCVAGGSDRSSNVSPLTNPLRVQPDDRYFGPLGVRCLNFNPQEKANDRCELKYAADRNLESSYLDLSILYTDEPQYDDQGKLKLFQCGASEAIAESEPISVHKIAISGLFGKLHNYCVDRVGSCPKSSDRHSVRERCRALVIGVYQKIIYEQLLPFLFGKELYERCGLNCEYNPHVESAVSQVYKSGPGRFQHIWIPDQMMYKPGGQSQWLPFNVFFHDHEQFECTAALAGLVESPIQVGRLSDAYVNIFYTEDGVHGTCLPCIDLGRNREAGLCPLVTLKHYIEQLIGEESKCYNTFEDLRDMFSPEFTDLLKQYYESPSDVDVLLSILENRRYPGAKLPKLVSQVTCLEFKRLKCTDRLFYTWNPYLGEGARHLIKALDFTALFALFTDMPDVPLEPFIVDGPRVATSDVRSYVKSLDYLFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXK9</accession>
    <name>A0A084VXK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010442</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC010442-RA">
        <property type="protein sequence ID" value="ASIC010442-PA"/>
        <property type="gene ID" value="ASIC010442"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010442"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013873"/>
    <dbReference type="OrthoDB" id="1936617at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028730">
        <property type="entry name" value="ZFYVE26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010442-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="14079" checksum="E67F7BA62E568CCB" modified="2014-10-29" version="1">MAQRAMVXXXXXXXKANFYQTKTKKINELELCNWQEVRLNSTGSVVETHRSLLMKLDPKELNNHINTILLQLEVTKFLAKCEAKGRQTVTVLPKVGSIVKQHFHATFEKTVYQSSPFPKSEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXM1</accession>
    <name>A0A084VXM1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXM1"/>
    <dbReference type="STRING" id="74873.A0A084VXM1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010455-RA">
        <property type="protein sequence ID" value="ASIC010455-PA"/>
        <property type="gene ID" value="ASIC010455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010455"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021043"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000112">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="30267" checksum="11E588681DF66A1F" modified="2014-10-29" version="1">MAHEEQSFNEFYTEVKEIEKRDSVLTSKQQIDRLLRPGATYFNLNPFEVLQLDCDTPLELIKKKYRSLSILVHPDKNPDNLERAQQAFEIISKAYKTLENETTRKKCLEVYEEAKDRTDMMIAEKKKKLKKEGKHEGVPEDDPSKYKHAIYVMVMKLFADIERRRQQLEVRDMEERKRKREAEIEEEEQRDLQKEWQKNFEESRQSRVNSWHTFQAGSSSSSSSSSVATAEKVKSKKPKKAKYTSFNPPKIKPETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZS2</accession>
    <name>A0A084VZS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004761-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011267</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZS2"/>
    <dbReference type="STRING" id="74873.A0A084VZS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011267-RA">
        <property type="protein sequence ID" value="ASIC011267-PA"/>
        <property type="gene ID" value="ASIC011267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011267"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002078"/>
    <dbReference type="OMA" id="EPPHEST"/>
    <dbReference type="OrthoDB" id="6427809at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF9">
        <property type="entry name" value="MULTIPLE WING HAIRS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="41"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011267-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="732" mass="80624" checksum="CB58EF9256BF6EFC" modified="2014-10-29" version="1">MTPSGGKNPLISQLGSQDVNDAPMSWNTNVKQENQRPPVFNPEDYVISLKKYGRRGGSNGNFKSIYETSSSEQSGSYEKLADNDRSQTLPSKNSDYRLPIPTLPEMDGEMTLRQFGSVTDLLTKLRADLRASFPSFVQEFVSSPLDGVSLLLEVLRAVQLSQSAPMNGTTTMLPGGLVRNNQSYQRRALLDELACLQCLSICCLRSPEAGVRLGTTPIGLLPLAAAATGTGIRSRIVALQLLTIACDKSTVCDGTHRSQMQGHTAVSEALSTLRLRCAEPVRFRLLVGMLNSGGGSGELQAIGMRFINTFLESAENTQTRLYLQAELFQAGLDASQMCKTISSSSPWMELLRGEVKRWDSIRIDIEQLQVQARSAEQVRSRLVILERRVQILHEEKTVLTTIERRLQERCAELQREVLRLKGAGAGTSNASGCSNRVEISNVCNLENRPVALPRQVPPQTKRNNTSENDDEGISSSETGQSSTPEPPRLFPAKDDDSNESSNKFSIALTQESIAPMHEHSGGVAEDDTNATIEDVIEELQNIVNDAEREISDQNEILFRQVDSKPEQMLFSLEITNEHEIVPVNLLPQPPRKTRSLAHLISNSSEGERSVYDMMVANGGSKGDFFEDEENARSNEHNPPFANNGSPSGAGNSQHITLPGPDVINSTSRDMEAATHHLTRPCLTPTKDSNRAILNVIMDARDMETRFLRVQSMEFDRQPAQPTAPQQFNGVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0I2</accession>
    <name>A0A084W0I2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP001160-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011460</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0I2"/>
    <dbReference type="STRING" id="74873.A0A084W0I2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011460-RA">
        <property type="protein sequence ID" value="ASIC011460-PA"/>
        <property type="gene ID" value="ASIC011460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011460"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006065"/>
    <dbReference type="OMA" id="AMILYKV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000515">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="209"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119231" checksum="21600B8E9D9D50DE" modified="2014-10-29" version="1">MVGVGGVGHSDSIDSNNKLVLTDLQNFRSNDVGWEPTKLRQTIAELRTDLQSQRNRKHAGCCSLHRKERRKSRKHKPSKVKLKGEKFEDPDPYQLAVRKTNYGKTKEKLKFVGEQFHDPDPFGLAIRKTSSTSSCTSDHEVSYQYRTQYAETHPATVYSSIDYVNRRQKIIAEMPEDDAASEHEPTTKQCADGGNTRAAIAQACAVGVKNVLLLGYGMTLGFPTIVIPAIQGGDGREPALEKDVTLSREQISWLSSINLICVPLGSIFSGMLAQPIGRRRAMQLINIPIFIAWMLFHYASDVNFLYFGLALAGLSGGLGEAPVLTYVAEITQPRYRGMLAATGSTCVILGVLMEFLMGSFLKWRTVALVSSSVPVLAALLLFLIPESPVWLASKGRLEESKSALAWLRGWVSKEDVYEEFKELEQQMSKAAEIQKDFTIIDKAKLYTQRAFLQPFGIILLCFFIGHFSGMTTLQTYAVQIFHTLKAPINKYYATCLLGLTELIGTLFCVFLVHRTGKRPLVFVSTIGCAICFFGAASYAYFLNDIPGGSVQNVVANVSSIRADIAVIPLRSKEVIAEWKNSSVIELLNLTAIEPSKNGSTNILETPPQLRHNGSSDGILYAAQSFTNYYLNDSLDEPINITISYGEYVQSAIPKDVFVPLPLVNRNKLVWVPLTLLLGSAFLTHIGIRLIPWILIGELFAPNVRSGGSGLAGGIAYIFGFIANKTFLKMLAIFSLPGTFWIYSLVTIVGAMILYKVLPETEGKTLQEIETYFASPRKRSVRFDQEAPAPRPGPKLSTGSAAAVQSPPPPIPPKPYPLKDDIDRARRISLLPRQMSQSSRNTTVSDFSVASFNSQGTAQLSRSSSRTSYTLEDTHVQPEPQIFRKISETLPETTTRRQSEHIPASPKPPAIVRNHSTNTFSKMECPSPPASRRRGSAVGSNHLFRDVYEMHLKIPPHKSQPMTRPVRARAKRPPPSHVVDFDTWDSNRKFEEFLKRHKAQEGPPVMRPMRNVISAHDLKAFEVKHREVLKDRNFFNSATKLTSTGGGERGETHFSYEGGMANAAFHLSSSNESTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0K3</accession>
    <name>A0A084W0K3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0K3"/>
    <dbReference type="STRING" id="74873.A0A084W0K3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011483-RA">
        <property type="protein sequence ID" value="ASIC011483-PA"/>
        <property type="gene ID" value="ASIC011483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011483"/>
    <dbReference type="OMA" id="SIMIDQE"/>
    <dbReference type="OrthoDB" id="9946564at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="26368" checksum="D5CFD321422CDFE7" modified="2014-10-29" version="1">MPRSYSRSPSRSGKSDRKDKYTTRRRSRSKSRDYDKYHRKDKSEKKRRRERSKSRSVASSSSYARKASYRNRSGDRKYKETSRRTSSRDRYRRRKSTERDRYRRSSSSTSSSSSSSSSTSRSSASSSSSQSSKKSSPTVSTKQSLGKEYVFKSLEDACEEPSEKACKLQKLNADEFVPQTFVSSRKMPPESVSTNIVIDLESQTIKVPTVEKSVTEEDPIFHPLVSNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0V2</accession>
    <name>A0A084W0V2_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011695</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0V2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011695-RA">
        <property type="protein sequence ID" value="ASIC011695-PA"/>
        <property type="gene ID" value="ASIC011695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011695"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003695"/>
    <dbReference type="OrthoDB" id="7744840at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="468" mass="51006" checksum="B7886A94E63EAE93" modified="2014-10-29" version="1">MVSIEGSVCGRTCPNSPLIFTQRTLLPVGLLLVLGRDILAAPGVELPAVPPVPSLVEQLAVVNYSTDGPVTVTTHIENAAGDKLDFNGDHFFGRDQEKHDFNRQAHVNLEHVRSQVPDLRRFLGRSIVKREGYPYPPAVVPPTHYEPPPTSPPTTTTTTTTEVPPTTPPGVPHEVYGLPPGEPEPQPCASKTWGDSPDCLVGELLPLLPVADLPVVPPVEQNNEEDLSGNTWQEPVKSSLYELTELVGNVFDGNVEETTDPNEDSTPSVVASGCTDCTFSQLPELPALVYPVLPTNPPVTPPPPAVPLPEPQVPDCLPLGYLKTQPKAPLQAFEKTVLREAYDEPALVDLRGGQDKEKNANVLSTQSQVILVRGMEPYPVLKTKGHQRTSQNRPTKQRGSVRFVHTFKRTDNKRGKLNEDEVDGLAEGGQPVDGNQYVLCTVDCYTLEEKVRAPETPAMEIPSDGRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W190</accession>
    <name>A0A084W190_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Cation channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011812</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W190"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011812-RA">
        <property type="protein sequence ID" value="ASIC011812-PA"/>
        <property type="gene ID" value="ASIC011812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011812"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="15986" checksum="181B7D9F1B650A88" modified="2014-10-29" version="1">MIERGMMPPAIVALRQPSSQPKAECSIGANVQLTASELADRSAAGGGTFDSQKKSTSSPPNWPSQQQQQQQQRGFGPTNRTQTHVTVDGNGNSASTYSGAGASGFTPEKAIVMRRRSPLIGRPSAETLTALSVVISAVSGVRGSDRIFIRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1K9</accession>
    <name>A0A084W1K9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011964</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019381">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1K9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011964-RA">
        <property type="protein sequence ID" value="ASIC011964-PA"/>
        <property type="gene ID" value="ASIC011964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011964"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011964-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11985" checksum="5D4EC91282C926E4" modified="2014-10-29" version="1">MGLSFALLKAQELKTKSRRFETTCKTYNRQLSLVYYLIIIIEPIPEDTGAMRLTLIICTKSSILEGEWGFASFLYTLCSVHRLSNLRLVHRPMQVASGNAFRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1U1</accession>
    <name>A0A084W1U1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Casein kinase I-like 3 isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012074</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1U1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012074-RA">
        <property type="protein sequence ID" value="ASIC012074-PA"/>
        <property type="gene ID" value="ASIC012074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012074"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="147" mass="16122" checksum="39EB86CA24603FA8" modified="2014-10-29" version="1">MLRLRPKRRQGGGSGKYNVETNGTRGKRETGTNGTANNQVHITRNGMEVGVFSWSVLWTQQKQQQQHEGKQTQDKQPLPAGTGNQECLRILEQMTLGGETPKNKGRKNKNVPEMNLLQKPEKPRTSGEDRTGGWLPTSADAAASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Q4</accession>
    <name>A0A084W2Q4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012374</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525277">
        <property type="protein sequence ID" value="KFB44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Q4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012374-RA">
        <property type="protein sequence ID" value="ASIC012374-PA"/>
        <property type="gene ID" value="ASIC012374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012374"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="15002" checksum="E1EBCD09D22A6260" modified="2014-10-29" version="1">MGPNDARDRAGFLRFPPREPTIPGARVIVAAPPRRRLMEVVNKTNNQNPTTIGSTKPPDWYVVGGTWPSGGLCRVRIVDDRFRSVGKRYRFWEEDRKKMAANAHELELRSEPSKKPRSTGSPFDDDQASRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Y3</accession>
    <name>A0A084W2Y3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012459</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Y3"/>
    <dbReference type="STRING" id="74873.A0A084W2Y3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012459-RA">
        <property type="protein sequence ID" value="ASIC012459-PA"/>
        <property type="gene ID" value="ASIC012459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012459"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001112"/>
    <dbReference type="OMA" id="HARSHQA"/>
    <dbReference type="OrthoDB" id="444338at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="29199" checksum="ED592A8AAD281E7B" modified="2014-10-29" version="1">MSISPKEIANEENQSQSGGNQQDPSVEQDANNPPLQPNVVLQPPAPTPSGMNPPITTQPSTEMQPAGLMTMPQAIPQCPPGLENLYGTGGLVVHLESPVTMVGPNELMNKYNIKNALGNLVYRAEELANIATRKRYGPLREFDIKVLDNFQNEVLHFRRDHKRCACCCFPWGLQKVDVSLQSGAMVGTIQQRQTLWNVEFDIKDQYGQTVLAIRNTTPFGRLSFTADAIYFIFGMDGTEIGKLTKKCVAQKFQEPFHARSHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3B6</accession>
    <name>A0A084W3B6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008175-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525284">
        <property type="protein sequence ID" value="KFB44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3B6"/>
    <dbReference type="STRING" id="74873.A0A084W3B6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012603-RA">
        <property type="protein sequence ID" value="ASIC012603-PA"/>
        <property type="gene ID" value="ASIC012603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012603"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000101"/>
    <dbReference type="OMA" id="IIMRYRR"/>
    <dbReference type="OrthoDB" id="6431754at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6243" checksum="DE19BBA816AFB6F8" modified="2014-10-29" version="1">MSDKQADTVYDILIPSFIIAGLFIVNGIVFAVIMRYRNKRKQRLDLESKELAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3S7</accession>
    <name>A0A084W3S7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012788</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020127">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3S7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012788-RA">
        <property type="protein sequence ID" value="ASIC012788-PA"/>
        <property type="gene ID" value="ASIC012788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012788"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012788-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="10110" checksum="8658D0C9B3246781" modified="2014-10-29" version="1">MAVEEEGEYVLSRVWTVGTGCTRWPLRLSNRFRRPEECQQRTIRDGTECERSASPGGSGAQFEEIEEKFFRERFEAVFERGAEPNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3U9</accession>
    <name>A0A084W3U9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012804</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012804-RA">
        <property type="protein sequence ID" value="ASIC012804-PA"/>
        <property type="gene ID" value="ASIC012804"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012804"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012804-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="24127" checksum="B797EC11DCE4FDC2" modified="2014-10-29" version="1">MNFECVGAASTTRFDRHQPGRNPYLGGAVEKCSTAADAVSCKGASGRWNLAIATNPRPNRREVEGGNKFCAQEKLETTPPQHVVALHAGQGSGAGFVEVFSMSAVLVERGSLKEEGEEGGESRKLMCDGLVEAKTEGSFIHQPEAPRLVALELYLHSIDNLLGGGLHIAMATRRARGGLVQFVACNLCHPNVAKIHLNGQSYKPSAIGQPKQERETSRQRSAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4P2</accession>
    <name>A0A084W4P2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013147</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4P2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013147-RA">
        <property type="protein sequence ID" value="ASIC013147-PA"/>
        <property type="gene ID" value="ASIC013147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013147"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="17119" checksum="7BC38CC317BCE6FF" modified="2014-10-29" version="1">MTGSHNLMTLHIRTLALLRDSLPPNHRKRSSFLPQRHPPPFPVTHYVAVAKANLLSSLCPFFICQQPGNPCLDRGPEGTLLPSGAREQRCVHYRTDSFSLSSQTPPPYLFINRRLLIIGPKEGSKPQDTERRIIVFASSSPSVPDVPPHPVLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5J0</accession>
    <name>A0A084W5J0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013416</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5J0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013416-RA">
        <property type="protein sequence ID" value="ASIC013416-PA"/>
        <property type="gene ID" value="ASIC013416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013416"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9918" checksum="96F666D535183EE4" modified="2014-10-29" version="1">MCLFNAHCTYAMVVYGVYSSASRIVAAANVLDSSYHDGDDNDNGAQHDEYKWRGCSMTVRIRARDKTGLIDKHLRGFIVRWILFGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6C5</accession>
    <name>A0A084W6C5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013744</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6C5"/>
    <dbReference type="STRING" id="74873.A0A084W6C5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013744-RA">
        <property type="protein sequence ID" value="ASIC013744-PA"/>
        <property type="gene ID" value="ASIC013744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013744"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000185"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023634"/>
    <dbReference type="OMA" id="KYSTHHE"/>
    <dbReference type="OrthoDB" id="6758292at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784333" evidence="4">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="31956" checksum="F1F761BFAA43893E" modified="2014-10-29" version="1">MMKITIATLALLAVAVFGYEHEHQDYHSHPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLHEADGTERVVEYSSDKHNGFQAHVKRVGHAHHPEVYGHHEEGYSYGGHGHGHASSYANGNLSPELASSQQSTHRPSSTNIESTENTKETLSKMMKITIVTLALLAVAVFGYEHEHHDYHSHPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLHEADGTERVVEYSSDKHNGFQAHVKRVGHAHHPEVYGHHQEGHSYGGYGHGHASSYAKLDQHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6N1</accession>
    <name>A0A084W6N1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009292-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6N1"/>
    <dbReference type="STRING" id="74873.A0A084W6N1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013835-RA">
        <property type="protein sequence ID" value="ASIC013835-PA"/>
        <property type="gene ID" value="ASIC013835"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013835"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019455"/>
    <dbReference type="OMA" id="MMLRRIC"/>
    <dbReference type="OrthoDB" id="6350321at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="BACK"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22667:SF0">
        <property type="entry name" value="AT01380P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="157"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013835-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="373" mass="42888" checksum="7BE1258023F1E0A8" modified="2014-10-29" version="1">MREAIDDEAPLDAPSDDSFLQHIDETELEHALKPVRTSNRPALWPLMERRIKARENTDLQVHIGDELIHCHLLPLQCFSEYFERQVTPGQAVVELPEQEIRPAAFRIVYEWILDSNQPLEWQHFVAVLSAAEFLQVPALIERCWLHLDNPRVVENVAFYVYMQAQQFATSNELQTMMLRRICRYFLALVSTPEFCELSLADLGVLLSSNIIAIFDETDVLYAACQWLLYDWLDRKELIEDVMCLVRFKSMHTGDLARLCVFHECTELQPILRHPATKQLVDEALAYICSPRNIAGSSERATTGDGRKRSSAERVRLVPDSLETLAYVTGEGSFNEFKIFLHVMQKKPTIWRTFRVSEENAGLLDDMVGCTEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6U0</accession>
    <name>A0A084W6U0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">COP9 signalosome complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020948">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525310">
        <property type="protein sequence ID" value="KFB45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6U0"/>
    <dbReference type="STRING" id="74873.A0A084W6U0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013899-RA">
        <property type="protein sequence ID" value="ASIC013899-PA"/>
        <property type="gene ID" value="ASIC013899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013899"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003909"/>
    <dbReference type="OMA" id="SNDKHVH"/>
    <dbReference type="OrthoDB" id="9972368at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029391">
        <property type="entry name" value="CSN9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28562">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15004">
        <property type="entry name" value="MYEOV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013899-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6756" checksum="7637093FB07D8CBA" modified="2014-10-29" version="1">MKPNVVADEMFPEGPGPFMDLEEAGGSTGLLMDLAANEKDVHADFFNDFEDLFDEDEDAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W772</accession>
    <name>A0A084W772_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014038</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021162">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W772"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014038-RA">
        <property type="protein sequence ID" value="ASIC014038-PA"/>
        <property type="gene ID" value="ASIC014038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014038"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="13981" checksum="0A7850F8FC399EFD" modified="2014-10-29" version="1">MSHFELEVIGFSLSPRGQTVYRMLAWRTQTVNEDEECHRATAANPFPHHPSSASPPSNDREAQRQQQCGHEEEAECVPASYRIVLPSSMRPPAAWYASTAPLVESHTTPRRVHRQASAAAKATTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7D7</accession>
    <name>A0A084W7D7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014157</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7D7"/>
    <dbReference type="STRING" id="74873.A0A084W7D7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014157-RA">
        <property type="protein sequence ID" value="ASIC014157-PA"/>
        <property type="gene ID" value="ASIC014157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014157"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023069"/>
    <dbReference type="OrthoDB" id="5847285at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000021">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="321" mass="35381" checksum="6E961C44D8F1EFA6" modified="2014-10-29" version="1">MKINDNDLPPYGCLPGVVGTPLSSLRLIAAATIRDSSSGRCGRCCRCRYCTSRCGLLQIPRAESREQRKSLTLHITSGNGCILQTASNWFLRSTGWLIICTLHGDLWYDEKSKLSSGGQSAPQLGGYAPLPTVIEDGSFALQPEKTANVVSEELLMDFECVYGNVELINQLTPPQTPPQSSAFGGVGGSVIPIEQQFSIPDSADSSYYGSRNDDDDEWSPAKNKKLNLSGGGAVTKKRTTGTTRPYGRGTEDKKSRKKEQNKNAATRYRQKKKAEIEEILVEENQLRDLNEELKKKSSDLGREISVLKKLMRELLRSKGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7N0</accession>
    <name>A0A084W7N0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014230</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7N0"/>
    <dbReference type="STRING" id="74873.A0A084W7N0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014230-RA">
        <property type="protein sequence ID" value="ASIC014230-PA"/>
        <property type="gene ID" value="ASIC014230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014230"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003067"/>
    <dbReference type="OMA" id="WGSLCCI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014230-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="486" mass="53205" checksum="6F0C4E6073DE97D8" modified="2014-10-29" version="1">MSHMPVFAGGFMYSPTTVYRCYSFFFPPLQTVNLLGVSYGTISGWSSSALPALQSPLDSPLQRHGAITQEEASWIAGTLCLGGVLGTLVGGVLVERLGRKWTAWTAGLPLVACWTLIIVADHPGHLMGARFLGGLGGGIVYVANPLYVSEIAAPKHRGALSSMLVLSCCVGMEVAYTTAAFLPYRTIPWVSIVIPLVFLIGFVFVPESPLHLASIQKHEEAERSLRYFRGVPAVKGTTVPEEFERELRQLERMCTDPQSTKQSLDRQLTWSDFNSPHAKRAFLISLTLMVLNQFCGCFYMMNYAESVFAESSSTLSLSANRSVIVVGLIQLCGCYSCTLLVDRMGRKILLVISALGTALGHSVFAAYCYGQYAGYDLTMLSWLPLVCFSVVIFIGSLGLGTIPFVVLAEIMPLKIKGFATTFCMVINWTVAFVALKYFSLVAIAFGMYGLLLFFAFCSTAGAIFVMFVMPETKGKDFQEIQKLMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7N3</accession>
    <name>A0A084W7N3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014114</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7N3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014114-RA">
        <property type="protein sequence ID" value="ASIC014114-PA"/>
        <property type="gene ID" value="ASIC014114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014114"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6823" checksum="648B8B3CFFD9B49A" modified="2014-10-29" version="1">MHNAINGGKEPLKARDYLSAGLAAGGWPIILTIFRCTGRTFVDVNEASMAREIAFAIQNTAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8E2</accession>
    <name>A0A084W8E2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014474</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014474-RA">
        <property type="protein sequence ID" value="ASIC014474-PA"/>
        <property type="gene ID" value="ASIC014474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014474"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="20848" checksum="D6F99BDE0321282B" modified="2014-10-29" version="1">MLELPVSEEGMVVVMMALGKPIGAIWFGMLKHVEEGVESVSVGSSTCSLTPFARFPEPGVPGAMLTHEKGPLTSVPPPPNEPVEEFDTHDPGHRDDTVLCASFYAFSRMTNFPAKKRRSENRTEKKLITVLVSFHQMDRVDVNKHTEIKKRTKVSTSNSTMISLSPNIAIKAATANLQGFGPADVDKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8G9</accession>
    <name>A0A084W8G9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011705-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014504</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8G9"/>
    <dbReference type="STRING" id="74873.A0A084W8G9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014504-RA">
        <property type="protein sequence ID" value="ASIC014504-PA"/>
        <property type="gene ID" value="ASIC014504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014504"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020385"/>
    <dbReference type="OMA" id="QQTHTEC"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="767"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1113" mass="121422" checksum="A90045D79B16A74E" modified="2014-10-29" version="1">MSWLRSSPLRQSFTKSGHSGNASSRSGAGGGGGGGLAGIRPFDATDCDPKACYDSFCIHWQQAYEIIVRSENYRSQSHDDVLGVVTHLDHMVTLLLMELHHCNKLSLPGQTAPPAPCLEHLLSENLLDKLYEWGIKTGRYANAVRLEQLKLYEQLVSHSRHQLLVHEPFLRPLLKLLASSQNEIYPPDVEKRLVILLNQLCVVLMQNVHLLDLFFFSTTQTQTHSQQTSNGGHTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNVGTYIATYSSICPVLVTGLGGLYSRLPNQIEIKTVDWYRITTDDVTELPELTLFMNSLEFCNAVVQVAHTMIRQQLLDFLYQGFLVPVLGPAILQTNVESQVSAMAYFDLIVRSITEPGLIQLVVRFLLDEEKFDGQRILDVLVERLNSNDSRLCMVTLSLFDSLLSLNCEDIMLELMLKYLLHCKHVPISHRYKINRVDPYTQAVEYFLNITPDIMRKVNSVLSINNNNNNTNTNGLGASQSGGANQRVMTPPGNTNNNTTPGPTSANGLNMNVSKTIGANWNHYGLNTTTGETLLANYQAYLLDARTRIAQCKHACDQWNNVYRYQKLSKANFVSLSSAGPSATPPNGGSAGNSLENAEDVRTLKVQMIKSFLSEFSIDSGTSGSIVGDQSVGVGTGTTSSASMFGGAGLVAATASGGKQLDSLQSIGDSSGYESLNVFSQSTSEQLPAPLVLPPEPKLQRVDSWKISNVREEPIGDLDLSEDLFAQGTVSLGPFLTAIWGKLQTFTSNCMYVNLHLTGLISHLTLFPLPLLHSILLRPDIPTTSDTPSFHQVLKILKQQIDAELPDTDESLEIADVARTFLVDREFRLVNMRKNAIESAASGGKLLNGGGSSMTSSLSQTTPMQLTPSSSYDPFKRQDSKRKSITNSFSNIFRRPGSVGSSNGNGLSHSPNGRHTQSLTAGSSTNASSGHQQQHQQPLSSPGSTGGGGYHPPTSGLLVSGGGRRESREAETQFMSYETPSNAATVAPVHHSSSGMAPAAMGGGNNELHLHGNSLEHHSSLVNYSVGASERQLNLAIGAVLLDEWLRELSAITQEQCIMMLSEQVQHQQRMAGVQQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAZ0</accession>
    <name>A0A084WAZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015630</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015630-RA">
        <property type="protein sequence ID" value="ASIC015630-PA"/>
        <property type="gene ID" value="ASIC015630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015630"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015630-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8230" checksum="9E52DB56923AB7DF" modified="2014-10-29" version="1">MQPKPRKDSQRTGVIDRTFPSVLQDQALPLAEVACRKLAYFIPSSCELQGGLPTDAPDLEWRSSGKIKQPHDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBD1</accession>
    <name>A0A084WBD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011472-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00015485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBD1"/>
    <dbReference type="STRING" id="74873.A0A084WBD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015485-RA">
        <property type="protein sequence ID" value="ASIC015485-PA"/>
        <property type="gene ID" value="ASIC015485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015485"/>
    <dbReference type="OMA" id="YDVKPPT"/>
    <dbReference type="OrthoDB" id="67933at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="557" mass="62576" checksum="CBF160F1AC258BB8" modified="2014-10-29" version="1">MWPEVEVVKTENRREIKLTGANVSKRIDANGGRLDEAIYKLTALNLLDVNDTSLQIISPQVKELRHLQSLLLFRNKITQVPATIGQLSELKVLDLSGNKLSTLPDELTALRSLTTLNLSFNQLQTLDLSKLDQLSVCNLSGNELTEVPQFYTGQVHHLTDVNLEKNRIVILPEVLTQQQILKVLNVADNKIEQVPKYLTKCIKLKEINLKGNPLKDKRLLKLVDQCRSKQVLDYVEKNGYQPPKESKVPSDSIQLDEQGAHDTSRPDPVEEVQLKIMVHKYTEHTLKASFSEEARTTRPYITLCIVRNYPITDMRKFLQMQNSLHDNECMRREEGTIATHDLTKIKGSVRYHAAPPGDIQITALGSAAQGKVTAEKYFADLEHQADQYRKEKKRNTYSGVYKFISLVQGKELFAFLSDDEKVISLPPLTNCDETKIAPTTTDMLLEVTSSVSHGSCVRIMNALLQRMLLMDVEVVSPTSAVNGQTTAKVGGEKKKKSKSKPSEPAQDSNVRYNRSATLTVEQVQLFDSDGKLHSVFPGKGDIENDEARRIFVEMVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBR4</accession>
    <name>A0A084WBR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015701</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015701-RA">
        <property type="protein sequence ID" value="ASIC015701-PA"/>
        <property type="gene ID" value="ASIC015701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015701"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="18511" checksum="53A9B29C860422F0" modified="2014-10-29" version="1">MVTQISSPKQISITDTALADDTINSFLPPATRQAGVHASPPTQRGLRVRSPSTEDEWTTTRSDRARPMDSRHRKKDSGSPPPKRSASSREMGKFERKREARGWEKSPRVESGNRCGMSNGRLNSEIGIWAFGRGKFEQTNQHRPPVEGMKCRWCQSTVRFGMPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCM5</accession>
    <name>A0A084WCM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016107</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016107-RA">
        <property type="protein sequence ID" value="ASIC016107-PA"/>
        <property type="gene ID" value="ASIC016107"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016107"/>
    <dbReference type="OMA" id="ATHKCHE"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016107-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="16731" checksum="67D77F694134A884" modified="2014-10-29" version="1">MVCSEVKELSCGLWWPVELHLYHTLLHSNEYSQPVTICYPMTSTLEPSTSTISTTETATLTAVTSVTETVTLAPNTELTISVVTSTIPVTVTLPTQTSSVTVTQTTTTTLPPFTTTSTVVVPSTLTIPVSSTATLTSTVATITTRITTTVTESCTPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDQ0</accession>
    <name>A0A084WDQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005030-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016511</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023052">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDQ0"/>
    <dbReference type="STRING" id="74873.A0A084WDQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016511-RA">
        <property type="protein sequence ID" value="ASIC016511-PA"/>
        <property type="gene ID" value="ASIC016511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016511"/>
    <dbReference type="OrthoDB" id="5863628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040010">
        <property type="entry name" value="ZN608/ZN609"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564">
        <property type="entry name" value="BRAKELESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564:SF5">
        <property type="entry name" value="SCRIBBLER, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="497" mass="48537" checksum="42F4C9C80BAE3064" modified="2014-10-29" version="1">MKIKRTKPGTKTSEAKHEIVKSDQNGTTPTTATLSTGGSIATLGGGSVLGSSSALTSTTGVTGMSTTTTLGGSMAGIAGVGGSASALNATGPGSHLTTDSDNSTGMGGGGGSGGGGNLSAGNSTSGGGHHGGGSGAGIGGINSSNTINSTKDKATHHNQRDKNDQSAQQQHQSQGGAGSVDVGTGIGSSSRSAAGSCSCVHHDVQVNGILQQQQPCSSASCIYAKAGSNGGDHTGSGNMALTSSHRLGPGGGSQGNSSVVSSSSSTLASGNNNTPNAPGPPLGKDVNKMLSIAIAGPGVPHGGAANASSNNCMTGTNTGGNIVNNIHSSGSGVLKAQLQAVSMAGAVPGDMGVASGTSLMGVSMFANSAAATSSAGGMSSATLSTHDDKRGSSPPPAKRHKADRKDMVDVCVGTSVGTITEPDCLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLIDCTKHDWAPPRFCDSPTEELDSRTPKGGKTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEA9</accession>
    <name>A0A084WEA9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00016865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEA9"/>
    <dbReference type="STRING" id="74873.A0A084WEA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016865-RA">
        <property type="protein sequence ID" value="ASIC016865-PA"/>
        <property type="gene ID" value="ASIC016865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016865"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017440"/>
    <dbReference type="OMA" id="RFDKQRM"/>
    <dbReference type="OrthoDB" id="10056216at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="12">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB48553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="21645" checksum="B0D910224A91178F" modified="2014-10-29" version="1">MANVCEPLTLAKDVKRSIELLEKLQMSGEVPATKLAALQKVLQSDFLNAVREVYEHVYETVDIQGSLDVRASATAKATIAAFAASEGHAHPRVVELPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVNGVSVEGENHEKAVELLKQAVGSVKLVVRYTPKVLEEMELRFDKQRAARRRQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEP5</accession>
    <name>A0A084WEP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006166-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00016688</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEP5"/>
    <dbReference type="STRING" id="74873.A0A084WEP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016688-RA">
        <property type="protein sequence ID" value="ASIC016688-PA"/>
        <property type="gene ID" value="ASIC016688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016688"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008139"/>
    <dbReference type="OMA" id="NMCVIPI"/>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="4">
        <location>
            <begin position="459"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="5">
        <location>
            <begin position="547"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="6">
        <location>
            <begin position="667"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="942" mass="103482" checksum="24D107F83960865F" modified="2014-10-29" version="1">MSLFKVRNWWKTQCPAVEPAYDSFSLHCARLCIEEGEKDSIVVGSHTGQLCIYQPSGGKPELPDLDAEESGQQEQPTLDANSDAFENVFQHSDVILEVRLPFPVIGVTSGKFTTASKNDTRLQLAVLHPMKLCIYQIVTVDGIAEHGDHTKLVPLYDHPLTKPAFSLCHGPFGGVKGREFLCVQHLDGSLRFFEQDGISFERSLANDRHIPSPVHYLPRVDCFVTVAPSWTLECFRYQDISEPIEDLRRHDPIWSLCVGEYALDLNVHQVSNSESVIVVLGENNLVCVTDTGKVRFIKKLDYSPICFHTFVVGWYWEPGARLILAVVSESGSLLLYENDQIIWSAQLPDVPVAIGRANVAGLPGALVTLGPTGALMVGYLGSEPQLFKVPALNLAPFEIARCQRELLELEREIRTGVDPSDASIANAAAERDVTVLLELAEATITGCTHPTDIPNDVPIEMCQLSVTVRAELNLEMLQITVATDQAVRCTKDSFLFRDIVAHSTESLQVWIYPGEPAIPGSLTVTVFCSYTNKQGITRVLQRDAQLPLRLFVKGCQPSKEAQHKITLSLVGGTTASGGAVGTLSQHFPEFLSGEGTSGGPSALGLQSLTVGGDGRRVTIVAAKNTNRFRVQSDDLALLCLGLECLMRRLSEGAMAKPKVILSGVPSVNELLKVFQTHHELRKELKRLETELETTTGQMRLFERRFVVKLQERSLRALDGTLMLLKRNHSAVAKACQQLKTARQQVKLSQIHMTAVLHLFGLCYSHSANVPGAGGKYLECLRGLLTSTVIDSTEQSYEEMLLPVVRFLDQTGPLRKPTGTPTPSEGAIDDALDEATLYGTVGETDPTVCHDLLRRHLVRVLGRVNERMASGAKTPASGSGRNSVDFEDESLPEAHNEDGEEEEEEEKQEYEGEREKGAGSPSLKIGSSASEWVNYEKVSDLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEP8</accession>
    <name>A0A084WEP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016692</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016692-RA">
        <property type="protein sequence ID" value="ASIC016692-PA"/>
        <property type="gene ID" value="ASIC016692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016692"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006797"/>
    <dbReference type="OMA" id="HVPYVKS"/>
    <dbReference type="OrthoDB" id="7765004at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007614">
        <property type="entry name" value="Retinin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931:SF3">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04527">
        <property type="entry name" value="Retinin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784676" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="20289" checksum="F2AC879C108B0E24" modified="2014-10-29" version="1">MFRLVVLSAVLAVACAAPSQLVHASPLAYSTVVAAPTLVAQKEISYQKSIVEEPGVAHVGTIEKSVPTGYSHQSFTQYHNKQVAEPVFAPAVKKTVVTTPVEKTTYVQAATPVVYAAPKTTYVEAAAPVVYAAPKATYVEAASPIVYAAPKTAYTYAEAPALAYAAPLKTSYISSYPSVYAAAAPAVYASQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEX7</accession>
    <name>A0A084WEX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">GTP-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016779</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016779-RA">
        <property type="protein sequence ID" value="ASIC016779-PA"/>
        <property type="gene ID" value="ASIC016779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016779"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7644" checksum="82670C14EBDC9830" modified="2014-10-29" version="1">MAESHCGPILAHRVSGACTGKAFAGGRKERNRRIKDVPLFRLEVIFYDYYPKRMLPACFDSRRVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF86</accession>
    <name>A0A084WF86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000949-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00017142</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF86"/>
    <dbReference type="STRING" id="74873.A0A084WF86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017142-RA">
        <property type="protein sequence ID" value="ASIC017142-PA"/>
        <property type="gene ID" value="ASIC017142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017142"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010619"/>
    <dbReference type="OMA" id="NAEDCFY"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784789" evidence="11">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB48880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017142-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25396" checksum="A10BA5A0F8905D61" modified="2014-10-29" version="1">MSKKPSLHQPKGSGFGLILFLALSHTVSLVNSVELTFELPDNARECFYEEILKNQSATLEFQVVSGGRYDVDLTLESPTGEVIYRQKQTQFDSYNFVAAATGIYTACFSNEFSTFSHKIVYMDFQVGDEQPLPGLEEHATVLTQLESSAQEIHKGLNAILDYQTHHRLREAQGRKRAEDLNERVLWWSLTETAAILLIAIGQVLVLRNFFSEKKPSQMNYPLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFE5</accession>
    <name>A0A084WFE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000856-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFE5"/>
    <dbReference type="STRING" id="74873.A0A084WFE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016938-RA">
        <property type="protein sequence ID" value="ASIC016938-PA"/>
        <property type="gene ID" value="ASIC016938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016938"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012988"/>
    <dbReference type="OMA" id="GPIRTNS"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19871">
        <property type="entry name" value="DSRM_DUS2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044463">
        <property type="entry name" value="DUS2_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
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    </dbReference>
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        <location>
            <begin position="379"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="505" mass="55943" checksum="F87135BE2BEF0CF7" modified="2014-10-29" version="1">MVRVGTLPMRLLALEYGADLVYTEEIIDWKLLRAERLTNDVLGTIDYIDTTDGTVVFRTCAEERNKVILQIGTASVERAVAVAKMLQQDVAAIDVNMGCPKDFSIKGGMGVALLYDLPRAKAILEGLVSSVTIPVTCKIRILPDLEETVQLAKELQSTGISAIGVHGRTKTERPRHPVNEEAIAKVASALHIPVIANGGSQSITRRHDVVQFARRCGTTSAMVARAAEWNCSLFRADGPLPLDDVIRRYITLSVRYDNSPSNTKYCVQMMLRSLQESPIGRRLLDSQTMQQICDIWDLGEFCRETQLKYHHAGIKGRRACRPRTLSNEESEEKANESGQVASKKQCLEENDQNQSAPTPLLQNNICFIRSNFPSDNDLPKTKLYTYATRNGLPKAQYEVQQKDKLFRATIEFGGQRYSSSFWEKNKRFAEQGAALVCLLHLGVEERSALIANGAMLPEKESTAAKGDDAAKTGTIKAPPEINTEMLPKDECLQNNGQSVAEDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGK9</accession>
    <name>A0A084WGK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017478</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGK9"/>
    <dbReference type="STRING" id="74873.A0A084WGK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017478-RA">
        <property type="protein sequence ID" value="ASIC017478-PA"/>
        <property type="gene ID" value="ASIC017478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017478"/>
    <dbReference type="OMA" id="GHVGDKY"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017478-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="311" mass="30007" checksum="85828D95E17045BA" modified="2014-10-29" version="1">MGDGGGGGVVAGGVEMVEEDDEQHHGGGGGGGAVVLQEDDDDDGTTIVMDAASVAAVQAGEMVIDGDTVGGNGDDADGVIIDTDGDDDPSDGQLHHQHHHHHHVHHVVEEAEELDDVEELEHEEIVQQFNGATIVTVTTASGFGGGGGSSSGNGGGGGGGSGSGSGGTTVVGLPRRATVRSGGSGISFVTTDVLPGTVVGGGRRRLTGRTATIVSGDGGEVGGGGDSLGSCEVGDVIITSGGDDTVTKPEGEVGPPEGGATGGDGDGEEGGGGGVVMGGGEGTTEEEVGVGGNVVADHAGLPSSYKHFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGN6</accession>
    <name>A0A084WGN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cyclosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017479</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023647">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017479-RA">
        <property type="protein sequence ID" value="ASIC017479-PA"/>
        <property type="gene ID" value="ASIC017479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017479"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7010" checksum="BA68D1254C918DA1" modified="2014-10-29" version="1">MKPRSPSDELVRTWWLWLIRGSITTRPRGTMVFVQLDGLNVRGGFGLELVSVGPLLITPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGW0</accession>
    <name>A0A084WGW0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2052 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017666</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGW0"/>
    <dbReference type="STRING" id="74873.A0A084WGW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017666-RA">
        <property type="protein sequence ID" value="ASIC017666-PA"/>
        <property type="gene ID" value="ASIC017666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017666"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019288"/>
    <dbReference type="OMA" id="LDVYMRH"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="360" mass="42838" checksum="254534ABE0D5EEE7" modified="2014-10-29" version="1">MTPAVIVNDLFEHISSNPRVFFKNQQINDPELSMVEKENILREVLNKSHCTFLSRFGPFMKDEHLRYFEQDEQTLAYSPDERYEIDYHLERIRRLRNGGRATEVRNRRYAALQKMCNDGTYFSEQEMMQREPLLYEQLVGQYMTEKEKRDRDASVPVTPSVVNIIFNQMDKDEAKETLQKLETEEYQEEQHLEDVEETKARSRPSSPGFPRAQWGNFDDEEETRLEARRHERQKKVRRRQLAIPPAHLITAGERNLLRDEFIGVMYARFIAGEDEEFDYSRVDDSLEYDDLDIVEQDEQEKYFDEDDESEPNASAIDCADEESEDDLDVYMRHLNHHLQQQERFARESNEVEACEYDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHJ0</accession>
    <name>A0A084WHJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP012334-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00018015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Found in condensed chromomeres. Binds preferentially to AT-rich DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHJ0"/>
    <dbReference type="STRING" id="74873.A0A084WHJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018015-RA">
        <property type="protein sequence ID" value="ASIC018015-PA"/>
        <property type="gene ID" value="ASIC018015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018015"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014204"/>
    <dbReference type="OMA" id="YNKQMQD"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21994">
        <property type="entry name" value="HMG-box_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000036">
        <property type="entry name" value="high mobility group protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF20">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB49684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12819" checksum="197D827F9C68C23B" modified="2014-10-29" version="1">MAEKPKRPLSAYMLWLNSAREQIKKENPGIKVTEIAKKGGELWRGMKDKSEWEYKAAKMKDEYNKQMQDYERNGGSKETVTKKKKGAKKVAKKSKKKESEDEDDESGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHW5</accession>
    <name>A0A084WHW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AGAP012289-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00017828</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WHW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017828-RA">
        <property type="protein sequence ID" value="ASIC017828-PA"/>
        <property type="gene ID" value="ASIC017828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012057"/>
    <dbReference type="OMA" id="YHVNRMC"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF36">
        <property type="entry name" value="ENDORIBONUCLEASE DCR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="363"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="19">
        <location>
            <begin position="573"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="16">
        <location>
            <begin position="849"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="15">
        <location>
            <begin position="1195"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="15">
        <location>
            <begin position="1418"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="14">
        <location>
            <begin position="1646"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB49809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1668" mass="191163" checksum="958D0AFF59936CF7" modified="2014-10-29" version="1">MLATNKQPSEEFVPRDYQVEMKNICLTKNTLIFLPTGAGKTHIALMVMKEKSYQLQSSVEEGGKRMFFVANTIALAKQQAQFFSRHMPFNVRLYTSEVNVDAWKEDRWKKEFADVQIFVSTAQILLDVLRHGYLSPVNINLIVFDECHRAVGQHPMHAIMKEMITVSSDMRPRIVGLSGTLLFKELKYAYLVPEELERLENTFNATIATVGNYEKYEHVRSFSTDPNEVVIFYTLPTMLSVGRLCAELAANYVKSLEAVHLSNYKTISLTTLRQGRAKPIKEVQKAVKSFMTQLQALGVFPASLAILGVIVQLELAKRSAECDKARVVMRDAIRFCETIRQMLASAMEGYSVEQQVLQFSSHRVRRLIQFLEGEYKQTDDVKRQSLVFVEQRFTAKVLYHVIKVYFRNMVKEQSLNPIITPEFIVGRNATMEESIEEIITQKQNRKVIENFRKHKLNVLVATNVLEEGIDLQMCNTVIMFDMIKTYVSYMQSKGRARMKTSKYLMMVPETQKSDFLNRIKLYGDISKELQKELVGKTIDRPLPLEQDVRNELLDDIIPPFYTPIGAKLDALSSLQLLNRYCMSMPRDLFTGSNATWERHDGVGGKFYVSVKLPLQSSVRETIYGQTVVGMKLARQSAAFNACKKLYEAGELNDHLLPISSVHKVEELSEKYFQHWKQIEPEKNPRVAGTAKNVRAHKIRYPSETIDCTPRADGEECLVYVLRVKAHFAAGVRYPHVKVLEDLFTSPNNFGILTRKPLPPLAQMQLFVTLGGIRVELVPEPLRVTLASGSGQLTLLQRFHLLIFRDMLKVWKGFTVLDVDPEENGFLIVPLLGSETIDWKLIEQFPYLRPATEASPRVRQQLRFEPERYLHRVIHPWYKHDPDQHYVVVRVREDMTPSTPFPNERFASFEDYFATEHHQMIFRRDDQFLIEVKGISTSLNRLHPGQEADGGSSSRTKHLEFQEILIPELVHNFEFPADYWLKATLLPSALHRIHYLLLAESIRVDLATNANVGQREYSERPQDLRCDLLLNRVDQKLAAKGGHYEDEDDDDDDDDELEEDDEDKERNKLNTEQFRELLVQIHSDASVYDRIEFPWQESEEPIDLERHWDNASRIDIDYYCSFLNKYGGEAKRLAVESNHSLTETNIEKDLAQLELEEAVSEAGSDRVGSSPGVIHVLQLKPESTANVCLQQADILEALTTKSSGDVFNLERFELLGDAFLKFAVSVYILASHDTWHEGYLTTCKGRIVSNRNLLYCAMLYGLPGMIKVYPFDPKNDWVPPLSVVPAPVRQPMVEANESPALLYKLELSEEEIRSGVVKPSTIDRFLPLIEKNEKPYGSTLQSVLQQVNISDKAVADVMEALLGVCVKTVGYERSFRVLAHFGIIPKEADVAQLLRNHQYPIVDYHGPNRLKIDQMLCAPGKIERVLDYEFRNRTYLLQAFTHATYSGNHLTGSYQQLEFLGDAVLDFLVTLYIYERNPSMSPGQLTDLRSALVNNVNLACVLVRYELHRYILSESPMLTTAIDRFVAVQRRKHNRIGDWVRLLCEEGDTPLVEYVDVPKVLGDVFEALIGAVYLDCGKNLDVVWRVCYRLLRDEITNFSLETPIQVVRQLHEHPDANPHFSAPRVEDEVVMVKLTYSLRNQRLKVYGFGKNKEDAKRAAAKIALSRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WID7</accession>
    <name>A0A084WID7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">XPA-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00018020</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WID7"/>
    <dbReference type="STRING" id="74873.A0A084WID7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018020-RA">
        <property type="protein sequence ID" value="ASIC018020-PA"/>
        <property type="gene ID" value="ASIC018020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018020"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003723"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000220">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000411">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="9">
        <location>
            <begin position="178"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="385"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018020-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="870" mass="101341" checksum="19055F09C3CEA13E" modified="2014-10-29" version="1">MPIASEVDLAEVFFNEEDLPYEEEILRNAYSVKHWMRYVEHKRNAPRMIINTVFERALKELPGSYKLWYNYLKTLRKQVKGKCITDPEYEEANNAFERALVFMHKMPRIWMDYCAFMTSQCKITRTRQVFDRALRALPITQHHRIWPLYLEFLKRFDIPETAVRVWRRYLKLCPEDAEEYVEFLQSIGHLDEAAQQLASIVDNENFVSKHGKSNHQLWNELCELISKNPDKVRSLNVDGIIRGGLRRYTDQLGHLWNSLAGYYVRSGLFDRARDIYEEAIQTVTTVRDFSQVFDAYAQFEELSLSKVMEALERNPNPTEDDEIDVELRMARFECLMERRLLLLNSVLLRQNPHNVAEWHKRVELYDGKPHEIINTYTEAVHTVQPKLAVGKLYTLWVAFAKFYETNKQLTDARIVFEKAVQVDYLKVDELASVWCEWAEMEIRQEQYEQALKIMQRATAMPKRKVAYHDDTETVQMRVYKSLKLWSMYADLEESFGTFKTCKQVYDRIIDLKICTPQIIINYGMFLEEHNYFEEAFKAYEKGIALFKWPNVYDIWNTYLTKFLHRYGGQKLERARDLFEQCLDGCPPELTKNLYLLYAKLEEQHGLARHAMAVYERATTAVKEEEMYAMFNLYIKKAAEIYGIPRTRQIYEKAIEVLPEADSRKMCVLFAEMETKLGEIDRARAIYAHCSQMCDPRVTADFWQTWKEFEIRHGNEDTMREMLRIKRSIQATYNTQINMMSAALINAAVTAGEPPKDAMRALEVKAAETTARAIAAVGAAGGNIMFVRGETQGGTAKDDRVVNPDEIDIDDEDDDEDEGEEDGENGAPGGGPGGDDEDISKKVPIERQTIPAKVFGSLRRETEEESNGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIJ1</accession>
    <name>A0A084WIJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011921-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIJ1"/>
    <dbReference type="STRING" id="74873.A0A084WIJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018080-RA">
        <property type="protein sequence ID" value="ASIC018080-PA"/>
        <property type="gene ID" value="ASIC018080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018080"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002782"/>
    <dbReference type="OMA" id="MMLLNQF"/>
    <dbReference type="OrthoDB" id="7735965at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="33518" checksum="DEFDE96421F6EDB4" modified="2014-10-29" version="1">MDALTEAYGSSEDPEVRQAFSDSILHILRPLSVLEVASRVGSRQGKLDRASPDGSDSSRSALSEPFSDLDESYILLDQRKKKPGKDDGDDMMLLNQFTSEFRQVYDQLVSDHQDRVEESLLPPEDSPEDGIPASDELIPTDFGVTDTDSFSPQFQSYIAEMLRKCDLKYHLDEKKKRLDQHRRRHRRVRKVQPVDARDPSEPAERDSLSGMWRMLDAVSEPNGFPITDGEYDLYEDERFEWLMREKLPWHRLEVSKKKCEQWLKMGPTVTKADERRSRESQRASGHQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ01</accession>
    <name>A0A084WJ01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Calpain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00018261</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023958">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ01"/>
    <dbReference type="STRING" id="74873.A0A084WJ01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018261-RA">
        <property type="protein sequence ID" value="ASIC018261-PA"/>
        <property type="gene ID" value="ASIC018261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018261"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018143"/>
    <dbReference type="OMA" id="RIRNCWF"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16196">
        <property type="entry name" value="EFh_PEF_CalpA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="10">
        <location>
            <begin position="83"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB50195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="776" mass="88708" checksum="787D39B081A19F0D" modified="2014-10-29" version="1">MPIVTRAVKKPAEVNGSKAKGAAVVKEKTEAGTTLHQSKSKFYPVKFDNEGIYFLKPNPNDPPLPGVQEYYRLRAECLSKGTLFEDPDFPADETSIHLMPTPCNHSHYKWLRPQEINPNAIFANEGFSRFAVKQGALGDCWLLAAAANLTIFPQLFHRVVPDDNDMIRGGRVGVDYAGIFHFRFWRFGQWYDVVIDDRLPTKDGRLVYIQSSQNEFWSALLEKAYAKLFGTYEALVGGSASEAMEDFTGGVTEMYKMQDAPENLYDIIEHGCNAYAMFACSLKVRPGQKSEDPTPEGLITGHAYSITKAMEVDIKTPKFQGKVKLLRLRNPWGNEAEWNGAWSDQSSEWKFIDEATKQKMGLTFENDGEFWMSFADFKKQFDKIEMCHLTPDCPIVRDSQGRFKWKTSAFEGEWVRGSTAGGCTNFMDTFWRNPQYLIDIAKPEDGQDQSTVIVSLIQKNRRSKRNKGIDCLSIGYVLYKVDPNVVQQQKPLTAEFFRRHCASGNATYINLRENTNRYQVEPGTYVIVPSTFEQNQEGEFMIRVFSETPNNMLENDTPVGVNEPKDIDTEEFKKELVSMEKLFHDVAGEDGEVDWMELKMLLDRAFESDIAKAAEGITKLYTGKQKDQGPVKQEIMLERAYLTDHGFSKDACRSMVAMLDEDGSGKLGFSEFQKLLNDIARWKAIFKEFDFDHNGHLSPFELRSALESVGFTLNNHIINKLMHRYCSKEGQIWFDDFITCAVKIRTMFDIFNAREKNNKNEISFKLEEWISQTIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ43</accession>
    <name>A0A084WJ43_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011757-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ43"/>
    <dbReference type="STRING" id="74873.A0A084WJ43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018309-RA">
        <property type="protein sequence ID" value="ASIC018309-PA"/>
        <property type="gene ID" value="ASIC018309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018309"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016640"/>
    <dbReference type="OMA" id="NWRKEYD"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="477" mass="54590" checksum="DF4762754E5CABD6" modified="2014-10-29" version="1">MTLPEALLKRLAKRGIIPDAQKVGANQNQPPLLSAGTADEDSDQDNKERDSENTSDQSDEKDDDVDDNRRDAEVINEEIIAEDYDEYDQVNPEAYEYASKKKSTPALEWTEKMKQKMTKRYGYQSVDGCQNKYNIYHLCTMYCVKRYGEVEFEIEKEYEKRTKRLLERYPLPKNWRKEYDIGCKAFYFYNKDTRVVAWLPPTHPDAKLTKSAKQLRRELMEEQKQKDAASEATPPTVIVESYPPPAKPLIGPTNTTALGSSGNVGPAVENLKPPIVNPPKRPAKQHPGSGEREDEKRQRTFSSGNDSGAADSGAADPGDRDRDYRDRNRDRRERDRDRDRDRDRRGDRDRSPPARGDDNRFGARDRDRNRDRDRDRDYRDHRDRRPPRGPPKSAPLDPMDPAAYSDIPRGTWSAGLEAQSQSATGSKKEKSDRKKPQLTSPKSDGDEEDGDEGAHEVLKISAVQEFHQDEDVDDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ56</accession>
    <name>A0A084WJ56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011771-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF4781 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ56"/>
    <dbReference type="STRING" id="74873.A0A084WJ56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018327-RA">
        <property type="protein sequence ID" value="ASIC018327-PA"/>
        <property type="gene ID" value="ASIC018327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018327"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011275"/>
    <dbReference type="OMA" id="TPAWKAY"/>
    <dbReference type="OrthoDB" id="6512497at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031962">
        <property type="entry name" value="DUF4781"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115:SF0">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16013">
        <property type="entry name" value="DUF4781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4781" evidence="1">
        <location>
            <begin position="133"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="639" mass="71721" checksum="C29541ECC9652F74" modified="2014-10-29" version="1">MEIPPEEWIERAKESMKKFLNRGGASRGDEPQTLCGAALQNTLGYALNLTMKDPNQWTDEELQLEYMEQLCFYDEESCKTIDKLTQQIYGQGVMPEEPCHLTILPIELYAEGKLYEVALFRYQFGVLEASEPKYVDSYGRVYGSFRDFLRNNKYPSAEMMYPKEGRLKADEDKLVEYEICKTPAWKAYYFKALDIATGIIGIAGATGAIFLSGGIATPFVAASIGSALYATGRSIDVLRDKSAHQESLNPFRDSESRTAWLSLTAHVLTFGTMPHISALSGVASTSHSIATGFKVCNFINETGNIISDLVICDTLSAMHSNYYNASIETRLAHAASICFWTKTVISIRQAELMMKNNAIVALKLFGFEDHFCDYFNNDSRAIDIGLRIVKHSLESNVLIASDPEDHSAVRIDGIRFSMKALLTCEPNEVEVLFDILLGISTASDRELFEEVRSLALPENGEDEQLSVLIHFLSMEAENESLPVAEMMEMLLQTYASVRRCEKKALIEATTFSLSVVNGINLGQGLCMRLKPAYILFASKRSHEPSNGNEMAAASDSENDRQTDRLLRVVLELSAEQCARLSEVIRHDPNYMSFFKQKSTSRTNVSTMTKDQSVKKEEQEQLLYDKLKEDILQAFENENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJG8</accession>
    <name>A0A084WJG8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018634</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024031">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018634-RA">
        <property type="protein sequence ID" value="ASIC018634-PA"/>
        <property type="gene ID" value="ASIC018634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018634"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="18123" checksum="BA524D7AEFEAB481" modified="2014-10-29" version="1">MCKNKNGAQRQPNNGCPRPGRNQSLDPPKKVDKIESCFQRIPHRLQQQQPVALAADHLVSILYHVDRLLHTKRFLSGANDRIASNYISMRGCTFVPTDVSPKPCDFATTSKQAHPNTVRSSTRSISKAAEKSREVSGWWSTPNALDFVGQFDPLDAIETVGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJX9</accession>
    <name>A0A084WJX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007043-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018564</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJX9"/>
    <dbReference type="STRING" id="74873.A0A084WJX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018564-RA">
        <property type="protein sequence ID" value="ASIC018564-PA"/>
        <property type="gene ID" value="ASIC018564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018564"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001586"/>
    <dbReference type="OMA" id="QDAMNIS"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018564-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="308" mass="34732" checksum="AB072426AAB5BA89" modified="2014-10-29" version="1">MVSACNPELPAFYTDVPKFRGWIDERDRIIGERNLLKESSCGEVRKNNVTNEIDKAVVNQYPWNVLLEYTRTKKDSKEQLLTCSGVLIHPRYVLTVGHCATGMLSKYKLSSVRVGEFNINTQEDVDSSVPGKIFTSQSIDIEKILPHPQMNKPLYSNDLALIKLKHEAGTGKENVLPICLPSVDEYKEEGLTLTGWKRSKRLFPKLEQDAMNISSAAQCQSQYNALQLNLPSTDDMMCASYRSRMKGRCHNYAAGSTLQYTKTVDQTERFFLAGLMMFSLPYCRVNATEVFATLVGSTEWIKSTVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLC3</accession>
    <name>A0A084WLC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019064</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLC3"/>
    <dbReference type="STRING" id="74873.A0A084WLC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019064-RA">
        <property type="protein sequence ID" value="ASIC019064-PA"/>
        <property type="gene ID" value="ASIC019064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019064"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013089"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="566" mass="60195" checksum="D21C91FCCDAD3B35" modified="2014-10-29" version="1">MDGSPPKTNRKVRFSLPEPTVPAVPSTTPVQKQRMAHGTVQYVNGTLISHQSQQTHPPAASHGGVSQSRAHQTLQVTPTPTSLSSTGPGGCSFKPKELNNKIVLHLRPSVSSLDSSGSDQGSSPKAGQSPGASIDGAKGPSANRQKSYSSQKPIHGTNGSTGSGGARSLKSLPQINQKFPSSEDVNNNVGGAPPIAGAGAANRQKSSDDLSSLGMWNHPVKKPTIILRTISASGTQQKSLTGRTSRAKGGLGKLPASGASFGVSRPSKTLISPHLQPMEGGGGVLIRVQENCTAVKCTNEGNGARIDEINVSSIIRGTNATNSTTPTTTTRPYGKSSQFLAVPEYSDRYEGMETVVSATLPDEEEEDDDLEDSEQDAGEESVSGRNGTRNGHASEENGGGGDSNATHNHHNNHVHEEDDTSFRCSRDTKLSRDKNTAQFWDFVERWRTNRALKKLESATYHHRSPSSSSDPHHNHQQHQQQAPHQQHQHRLEATGGSNASITPVSIGGSIKSDAKSEEGVPKAYTFDSFRTGTNEKGAPGLIDNRNACIEKASRKIVSFIYKPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLY4</accession>
    <name>A0A084WLY4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00019494</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01024321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLY4"/>
    <dbReference type="STRING" id="74873.A0A084WLY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019494-RA">
        <property type="protein sequence ID" value="ASIC019494-PA"/>
        <property type="gene ID" value="ASIC019494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019494"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013180"/>
    <dbReference type="OMA" id="HRYEYRN"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000523">
        <property type="entry name" value="Serine/threonine-protein kinase PITSLRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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    <sequence length="990" mass="113612" checksum="2FDB7F4D89E3469E" modified="2014-10-29" version="1">MSEGEQSEDGQVMSGVELSPSDEEETNDSLDIKPPQASSSYYASSKRKDKKAPKDRKHSSKEQQRYHRHQRMMVERERERDRDRDRDRDRGEKGSSRLDRDHYRDHYSQGARDQHRSAQGTSSSRTGSGSSGRSRSGRGAEGARESSARERHHTSQYELNPFYGEMRETYDSKLDRERLREREREHRSGDRGDRGERDRDREREYYEKQRRTVPKDTKITDSEQDLRMRLLHRKHRYESMHQRGGMLPEREREMAPADAEILQQEEADYYHEKRERRREQQQQQQYQQSRRHREEAEAGSGGRDGRTDRTRNRDRAEEVVEIVESPDRHHHLPKVAQTAEEREQEVRRAKLLEADREMLRRKELAREELEARRLRKEEERKDGRSETNTDESDEEDEVVEEEEDEEEEEEEDVEMVSDVEHEAGTRKKTRSKQQGESRRRKHGHPRGRRAETNSDTSSSLDSAESDRERSGQREDEENPPGSPLSVGDLVKSDRRHRKSNSGSLRSRRSHSQTRSGSGSDSEEFRSRSRSPRRRHEEADSSDSSSGSGHHSRSRSARRNQRGGDGADDDGASKQGPTGVAGAADGGKSPKDPKADDKPVVEVVEPKETLPPYYPGIQGCRSVEEFLCLNRIEEGTYGVVYRAKDKRTEEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKHKKQVFLPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPLKPYTSIVVTLWYRAPELLLCCKEYSTPIDIWSVGCIFAEFLSMAALFPGKTEIDQLNRIFKDLGTPNEKIWPGYSELPAVQKMTFTEYPVSNLRKKFAHLTSELGVSLLQGLLTFDPKQRLTAEAALQHHYFKELPLPIDPAMFPTWPAKSELGLKKALASSPKPPSGGGEFKKLGDDAVTDNAGFHLGGPTYAESRQLAMGPGFSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="1413" mass="152870" checksum="8E43C555268F52E6" modified="2014-10-29" version="1">MSDPEDLEDGEIEDDDDDVVVPAEDPPLVQPTPSDYKDFDADQLGNQEPSSKEPLGREQPLNKSGGQRVKPAPVVDDWATRVENAIANALIKDGVQPPMPTSVSHQGDGEEDPGTPGGGRKSKKRKKSSRGAGGGDGAQQQQQQQHHHHHHHHPPHSKQQRLDDQDDDGQMDYEYEMVNVRGSSPQDSAAHGHHGARDSGVSDSDEDDTHYSSDESRDRGEAHFRGKSRGDHRDRDREREREREREREYNRKKRKQARQRTNSKPSRDGRKRKRDDSDDEKHRPSGPRKMELCKFYLMDCCAKREKCLYMHKDFPCKYYYLGMKCREKDKCLFSHGEPLSDDLRAILLKHLETAPQEILGDFQRISRDSAIGMLNSTHRKLLERYGKAPGDGGGSKIPSLLDVPTVQPGSGSNHAANQKYRKSRWTGDNGGPALDGETLDLLKQLKDVISPRQAQDLEHMGIRTLDEISQLTVAQLNELGLSITQIHDLQVRAMNVQKNREAKNNSSNAGISQVDSGTVDSMENATPSSLEDVDLRKMPPAVEIGGAPELGGGSRDVDMRLFPPVEPLKQSPKAANTDNTTLTNASSSGDPILQGSSHHLVLKPPTVDYSQYIKDSNLSEDLDAVAADTSLLNEDDDDDDDDENHLKINIEEEEEEEKKDPTGESASDPYHEGTLKRTDSEGDTVEKPAPILLPPLVPPKIDYAQGLGDILMYGSLDKTSAKSLGGGGDGFSPRSHHRSPSPAKEEGASTRSTLLQDAWTPSMADSPSSTTSSSQQGKVSGTKSDQGGAKGGSSSGDRQRKTGASSIYDWYDSDNVPSSPDGPSSPVGGSSFGYGAGGYGKLGTLDLDDGDSYARGSEGPGELGFPFKSMMANYVPATEIDGSIGSHAPIQYKVYVVDVPKPNFKTIRRTIARPVPAKDRPTDPRLRRLFGIQSDEDEADDGTSSDAGIKSPDGSTPGASPLYNNPPTMPAALIVPPTGSASAVPAATNKLVYVVDVPKPNFKTIRRTIARPVPAKDRPTDPRLRRLFGIQSDEDEADDGTSSDAGIKSPDGSTPGASPLYNNPPTMPAALIVPPTGSASAVPAATNKLVSSGPRVDPRKRHAEKQQMEAQQQSQQQPGSGSTFGSSPQIDVQVILQKSAWYKDLGSKHKIMVNQQLAILSTEMKKFHNSDRSTERLSEFMHFLGSSNMLQHILTCLNVFVDDSVTFCEVPVVPNLPPPSHLAPLPMVPHIPPPGMPAVPLHVPPPLGVQGPMSLPPPLPTQTQQQPPMFGLGNKGPFGRPPMQDQPPPPMVGRPGLLGVSPNMPFEQFLAMGNVNKGGGEHPGGGNVVGGPPPPGAWTQGNNNGGNNNNGNNMRNMRNNNRIGHNFRNNNDRWNNNNGGPGPGGGPPMMMGGNNNGGPGGNNRRNNNNRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMH0</accession>
    <name>A0A084WMH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006629-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMH0"/>
    <dbReference type="STRING" id="74873.A0A084WMH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019892-RA">
        <property type="protein sequence ID" value="ASIC019892-PA"/>
        <property type="gene ID" value="ASIC019892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019892"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005748"/>
    <dbReference type="OMA" id="AWIMKNL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08705">
        <property type="entry name" value="RGS_R7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000162">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.60:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047017">
        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034483">
        <property type="entry name" value="RGS_Egl-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF6">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="440"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="576" mass="64199" checksum="F769243D1C1F6281" modified="2014-10-29" version="1">MVTMSTEATDKAVTVITGTPKKMMMNANGKCDGSESDKEKDREREKDKGSEMTSGNSSAPKTAESGGVEGVSSAVTVTAPVEEGSGRVGTSMAPATSSSSNDGKPSTTAGGAGSSSGPAGKAAGQPSHSHLTQTALSQDAPNILVYKKMEAIVERMQGEEGGVSVRTIKAFMSKVPSVFTGADLIAWIMKNLSIEDVNEALHLAHLLASHGYLFPIDDHQLTVKNDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKTRLELADYEAENLAKLQKMFSRKWEFIFMQAEAQSKVDKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEVDIKKAYRRGASTLGSGSCGTAGNSNPIEQLTRQIKLLKLKLERRTIKISKVAESYISYFEQYNEYDSFLTPPDQPNPWITDNTEIWDADRTAKDVSLKRVKRWGFSLRELLNDPVGREQFSKFLDKEFSGENLKFWESVQSMKAQPQSKVKEAAHAIYLEFLAPDAPCPVNVDSKSMELAREAVSSTAPPNRWCFDVAAAHVYHLMKSDSYSRYLRSDMYKEYLNGSKKKIKSIPNLFGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMT9</accession>
    <name>A0A084WMT9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006819-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019596</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMT9"/>
    <dbReference type="STRING" id="74873.A0A084WMT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019596-RA">
        <property type="protein sequence ID" value="ASIC019596-PA"/>
        <property type="gene ID" value="ASIC019596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019596"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019133"/>
    <dbReference type="OMA" id="LDWHGPH"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="117"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019596-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="436" mass="48702" checksum="CB858F5F26F14FED" modified="2014-10-29" version="1">MLSYLYTYLTNLPRWHLVAIVLVGYLVYYLMEVVKRPILAVSDGPFKKYLRKHIPTLEHKFWPTFWCVESRAQTVFASILRSNIMPDIEYRREVLTLKDGGQVALDWLETSCDPESPIIIILPGLTGESQAEYIKCLVMAANRTGIRTVVFTNRGLGGVALKTPRLYCASNCEDLSEVVKYVRSAHPHVRIGATGISMGGLILGNYLARKCDEAKSILTAATIISVPWDVHKGCASIEQPILNNLLGRHLASSLCRTVSKYDILRGEEFEWDMNQVLQSKTIKQFDSAFTSKHFGYKDVDSYYSDATLHNKLHQIKVPLLCLSAADDPFQPLDAIPVKAASKSSHVAILITARGGHIGFLEGWWPANKDQYMGRIFSQYFAAALFDPDNEFYRTAQLMMEHNLTTSTSVPGSPKVQTPPPSPVAAASAIRKKSIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN39</accession>
    <name>A0A084WN39_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019708-RA">
        <property type="protein sequence ID" value="ASIC019708-PA"/>
        <property type="gene ID" value="ASIC019708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019708"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002447"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16244" checksum="EA36B297F14CBE10" modified="2014-10-29" version="1">MSDADFLRGLRDDIADSTRKMMEEAPAAGGKAKVKKGDKEPAKNADQGKSSTSAPQTRAEGSDAVAKVAMELVQLSIETKPEQKLEMDAAQPEVRRTNADEPPPGMPEVMVRPEVKKSKKEAKQKEGKSKDKKIKEVKQKELKKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQC2</accession>
    <name>A0A084WQC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020646</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525389">
        <property type="protein sequence ID" value="KFB52416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020646-RA">
        <property type="protein sequence ID" value="ASIC020646-PA"/>
        <property type="gene ID" value="ASIC020646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020646"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020646-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9009" checksum="9E1D07F28B4ADE9C" modified="2014-10-29" version="1">MAPAVEVLTLVLRPNRTESEIRRVSQRVVGKRELAINCTAEQDPRAADDEVALCEARDRRLLYLAGITAATGNEWVYRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQT3</accession>
    <name>A0A084WQT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001398-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025723">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525398">
        <property type="protein sequence ID" value="KFB52577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQT3"/>
    <dbReference type="STRING" id="74873.A0A084WQT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020821-RA">
        <property type="protein sequence ID" value="ASIC020821-PA"/>
        <property type="gene ID" value="ASIC020821"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020821"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020821-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="21605" checksum="1222FF5582F9E19D" modified="2014-10-29" version="1">MSSENESELAVCEAKILFRQLKPFPTIDESNGYKIDTRHFIEASNQIIDAMGCFGKLFSPVVKDMRQNVQKVADKFKQNETLFMYLEDLILKDANGKDVPFDTVTDGLLWLKRAFEMIEMFFRNMLADETCSEQVKPHLREAYETCLLPYHGFFSPESLSAASFVPSQPNVVTWHIGNQCGQFVGVEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR06</accession>
    <name>A0A084WR06_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Tubulin polymerization-promoting protein family member 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020941</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020941-RA">
        <property type="protein sequence ID" value="ASIC020941-PA"/>
        <property type="gene ID" value="ASIC020941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020941"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7419" checksum="5F541D974F9687DB" modified="2014-10-29" version="1">MCVIRFWHKFFRTFSLPGETKNPGKVRPGPDETCRRTGALRGQGLSRLSAPVAFPFIATQTVRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRQ7</accession>
    <name>A0A084WRQ7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00021180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRQ7"/>
    <dbReference type="STRING" id="74873.A0A084WRQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021180-RA">
        <property type="protein sequence ID" value="ASIC021180-PA"/>
        <property type="gene ID" value="ASIC021180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021180"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008623"/>
    <dbReference type="OMA" id="TRCILVY"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB52901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="34921" checksum="3EE56C2237F865EB" modified="2014-10-29" version="1">MGFSLKLKTKSGQQHIVSKLTETTTVGDLKTRITELTNIPGDALHVVLGFPPFKPLDFSNEANPLPTVGISNGDTLIVEEKSLSAEERKQLEAAKRLEQDEKLAKELAAQGTENCGILLKKVVPADNSCLFTSIGFVLTGKVDPENSQYMRQIIAGTVNSDKQEYNEGILGRPNDEYCAWILQPEAWGGAIEVSILSAYHGIEFDVVDITNAIINRFGEDKQYGMRAFLLFDGIHYDPLYLESTNGEPPKTLFPIEDNLVYLQAEQLAKEAKSSRQYTDVNKFTLKCIDCDCFLKGQTEAQQHAQKTGHVNFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTP5</accession>
    <name>A0A084WTP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021825-RA">
        <property type="protein sequence ID" value="ASIC021825-PA"/>
        <property type="gene ID" value="ASIC021825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021825"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002707"/>
    <dbReference type="OMA" id="APIHMEV"/>
    <dbReference type="OrthoDB" id="7741829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785335" evidence="2">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="206" mass="21429" checksum="50E8D1149B41675E" modified="2014-10-29" version="1">MKSLISLVIVCSLALLDVAVSNPVVLVRSVRAARPQFPFINPYVNVPSWNPLQAGFGVQTPVAGVDLSVPTGLTITGGQQQARPGHPSGAAPSVPLQQPQQYYQNNAPAPNQGGFGNTYQTSQGAQPNVASNNVRPTQGEGLGTRLDEGNGNGQDPSLEEFPCENYDPSLQPVANDGTNPTEHPCAGIGDGNKLNPKQAALLSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU73</accession>
    <name>A0A084WU73_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Endothiapepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022149</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027003">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022149-RA">
        <property type="protein sequence ID" value="ASIC022149-PA"/>
        <property type="gene ID" value="ASIC022149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022149"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8093" checksum="40C692BCEDA23819" modified="2014-10-29" version="1">MAFSGSVKCIKPWGALEAGVPRKMEPIFFPLEIYNTVGVDCACPNQQHLSRLDFAGFGVEKVGLQQQQQQQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU88</accession>
    <name>A0A084WU88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022017</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027012">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022017-RA">
        <property type="protein sequence ID" value="ASIC022017-PA"/>
        <property type="gene ID" value="ASIC022017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022017"/>
    <dbReference type="OrthoDB" id="7789233at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="100" mass="11837" checksum="39F45BA48164005E" modified="2014-10-29" version="1">MRERIGDAEHKLDTKVGSMVQVMQQKKADTVYRNALHKMKELHGGRATIGDMTTNKEYDRNVKMLKMFDEPTKKMFRPRMKWGYLNKQIIKVPARLIRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9X3</accession>
    <name>A0A084V9X3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000158</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000828">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523910">
        <property type="protein sequence ID" value="KFB34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9X3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000158-RA">
        <property type="protein sequence ID" value="ASIC000158-PA"/>
        <property type="gene ID" value="ASIC000158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000158"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023704"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="28282" checksum="59956222261CD56B" modified="2014-10-29" version="1">MTMVLTCHIEPNKGVEQEDAAQFATNYTQSSYGMGGGPGGRQDGSGTSNSNNSPNAAISYTNAFPCGTLEPGRAGRTQSPAAAAKSLEALLIEIQDELGGVVKELREEIRELHSQVRSLSEQLEKLLKQQQREDKKLHRDGRKPIEQMVQEATIGSKGGKGRRKPCRTSRKSWGSSSPPNAAEKSEVARRREPRSQGSSSSRPEKPQARRQEPKSHQHQQEQHEDPEDWTVVQKKGRSGGKSAAQENRPKQKASYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAV2</accession>
    <name>A0A084VAV2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00000978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01004491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01004492">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524215">
        <property type="protein sequence ID" value="KFB35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAV2"/>
    <dbReference type="STRING" id="74873.A0A084VAV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000978-RA">
        <property type="protein sequence ID" value="ASIC000978-PA"/>
        <property type="gene ID" value="ASIC000978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000978"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002132"/>
    <dbReference type="OMA" id="DITEYCH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000978-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="16706" checksum="70F37CF2B88EEF65" modified="2014-10-29" version="1">MDHNHGGPDDMEMLCPMQMSFHGGSCEIILFPSWATTEVGAFVGATIGFFLLAFAYEGLKYGRELLHATDVIKPGAPSPAKRTLREALLSRAHVVQTVLHLLQVTVSYILMLIVMTYNYYLCLAVVLGAMCGYYVFGWVRNSAVDPTEHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBQ2</accession>
    <name>A0A084VBQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003803-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002022</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ASIC002022"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS019068"/>
    <dbReference type="OMA" id="RPAIVTC"/>
    <dbReference type="OrthoDB" id="8070503at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
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            <begin position="471"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
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            <begin position="821"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1059"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1119"/>
        </location>
    </feature>
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        <location>
            <begin position="1606"/>
            <end position="1625"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1625" mass="180112" checksum="2CAE4CE95E9A3BF2" modified="2014-10-29" version="1">MSASVTVHEIGTGPSPEVVTNPLSDFDAVRKDANEKLRIRRLVQVRQQSKELAAKVRQNYQQAKVTELAKIERTKREEVKAWKRKQVRQLQDEYARCIGEVGEAHKAAEAAEECAVWFEEKRATQQAVAMQRGRKAEKTAARERERKEALKEAKAHRKPYVPAKSIAVQANIPDPKLEPVREAIPVVRDEVSSTEPTLSPYEQFRSRREQSAVQCLPSVRIEAKVSDSEDELYCPGMGNKENIPSKGQDYSASAFTSPSDIRPSEGPPPRQRLQPFTQITELIQQRRQQQQRSRERHDESTVGQQKATHHRPTTAAPYGTSYGTQKAVQFDDTSENTLSFPTSTVLTRDDHRPPPILASDGSPRKVRPRKLVDQPKVSPVQQNQADSKTSLNRGQAVLPTGVVPESSTSSASYGASTKVQYYDYNTRFTKEYDQPMAFVHREERRVDDPTAMEEANRYEKLQQELAAARRTTVDRTKPALEKQQTRKDYEKLSKELDNLTRSETKLKSLAVPTKTIPTETTIKQKAEARQRKANEAIENLLQQRALVTCPVVRTETSIDVRKRARSGSRPPMVNVAEIRSDTFAPASTDVPAGQNVSSDSCASIVLGTFERPAIPLPTGDGRRAEGEGAGDKIDRLKELLEQLDEQRRLLAEELAKERKPDPISVGGVEELCAAMQKNTEVEKLERMKRRQEELLEQQRLLQNREREVEELERQLREKMAQLKKNKQQREDDTEKGTAATVHVETRGQKNSVEVVEQPSTATSSCSLEGQGEDNSERTGGDPVPVKIIITVNDKSTPSKKKHKKKLPSKKSPKVVVPVEPVKAKETPARGEKSVETEQPMAVTKEGTAVRTKKGPIRRVVEMDFSPGSTSTTSTVYRELPPKIGGLKINTILPQGPAGAKENEQPSVAPKHQLQRNPVPKPSSKPAPKETQQANLNPQLVKYIQRLLGMSRQSIDQLGVSSTTVSTPNASLVNVSSNAGQTVGHPPVDDESERMDRLRKFIDENYNFLQEIDETLKRSSDQSVSASDDSRPMASMDGDPNDVSRVEDVWMKTLRKREKGMKAKQVDDQTARPALVKVKTKKKRSESGPSEGVPAPAPPVSQPLPAAAAPPVADAGPSVSHGSNRIVTKEASLKSILKSPKRDASPKVAKIITPQGHVEIINLSDREEQEILDRYSQLTERCSQRITELSQMINQIGLSKDSGIAMSRPLTASDIRESPSEECSQAKEPPPFEPFLKDIHKPVLPPSVGRLHPAAGPAPSSVPSVLGSRKPPPVAITRYSPQLDLEVPVHELSTILEIDTPATVPAPSASKVYDVSSLSVAGERSDTAKEQLLIEARNKLLLVEPSSPDIGYARFPNYEEYTTGSPGPRMDLEQTEQPIVNETGLRLDLTEDREPERLQYRSFPGAAPSFDITEESRVEKSQSNVSDSSLPDVVAELKKFNIILKPFDQSLDDSNRSTPLSEVAAVRGEGERGVERSQPPLDLVSLGHDLEKVLRLPWAASMLKKNHEHKRRSQQQEDNSTSSSFSLIELKGQNNLTNKDDNDDDDNSRNGGSGKPPNLAKFIARELMIRTQSDLQSLTSSSELSSSPGSHSALLRSLLSISNLEHTSSHDGRGSRKQKEPRSTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCH5</accession>
    <name>A0A084VCH5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002569</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010758">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002569-RA">
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        <property type="gene ID" value="ASIC002569"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002569"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008954"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002569-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="12842" checksum="4C3BD1D0A4704474" modified="2014-10-29" version="1">MESSVDKMVLSGGVGAEIDARNSLQHGRGSFSPAATESGLSPDHRGDPSSMGEAANDAPSAAATSGPSPKLHSGHPPSITVPAARTVGMSPDETVDERPTAHDTTTSVTTPATSPARKRTILPGGANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD02</accession>
    <name>A0A084VD02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002786</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524639">
        <property type="protein sequence ID" value="KFB35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC002786-PA"/>
        <property type="gene ID" value="ASIC002786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010620"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="17971" checksum="7AE9544E5C21A1EF" modified="2014-10-29" version="1">MVGKDERKIIPNCPHRRQSRSPRRCSLYPIGSSAANAGTVIHNPAQAKPSADGMDDADGGVGGYGHAARVLDAGKQPPVLWKIRAPATTTKGTTRRLRASFSSPARSDSVEEKQISRLRSNRNSANLFKQHGGTSSTVDVVSVSIRVTFLSSMLLLAVDNLFYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEI7</accession>
    <name>A0A084VEI7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003681-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00003544</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VEI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003544-RA">
        <property type="protein sequence ID" value="ASIC003544-PA"/>
        <property type="gene ID" value="ASIC003544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003544"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013640"/>
    <dbReference type="OMA" id="KIACFQQ"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000091">
        <property type="entry name" value="Huntingtin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00375">
        <property type="entry name" value="HUNTINGTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3002" mass="340250" checksum="CB8FF2C5BD38F9F2" modified="2014-10-29" version="1">MLINQCLLETLVNRDLNVEAQRVGFYVNATSCILARARCNTYNPITGQLQQPLNTPAGTTGRTGANSLQISATGDLRRAVEALKTTECSAKEKVTHFGQISETIISIRPGTSTANSASYYGHLSSAIAVFILFCEESESGVRMAAEENLARVVRHCESTGNIIRVQRDLYHEIKKNGNERSLRIALNIFAHYCDTIRQRKARTYAQNLLPCIYSISKRREPALLECLCTFTEVFCQQLEAYLTDGEVLKMTELFLEDLGSDCATKRRCAARNTLTFVLGSRNPEFYANNAFNRCIEQLLKCGQLQQQPNTVLGVMGCFRAILPIVLRSCSIEKAIETFDLCLHFLREGTHTIINATLEVLLVILANVQPTVRKVLLSEQCEHRRMLLKRKTLKNSIFKLNPSESLLSSRKSSTDARSDHLLRPGTLALTSTPIKFPPPIDDRSLASASDIELDSLKSMDLDTESRTAPALQLECSGSLDPSGGSSVAAPAPDTLSLKSQKSTDSIGSFLNTLLTNSNAAESVTKFFRKSLDKPLPDDGEEDRLSMDSMASSHMSSNAETVRAELDVTLEIDLDDTDPATVVQAVQPAPTPTPSRDTLDVPISSSMIADEPPENTKELFIGAIYDQNLLEFTTRLVCSRFLLSGSRYVLIPDSIVRVSVKSLAMQIVAACVRLKPELLCLPLEKDAFREEYAVVEILNLEDAINELSQEASGGEDQPEATGATATPLQEEQESGLLEMKEDHFGECTSTTYFEYFSPMSLSLDQGLKSKLKSIEENFSIDNNEKLSRDLDAILSQSEPGPGSAALTGPSAAAVRRRELLVVPKVRTAARNDARQGRSGEADSDKVLTAMSVSDRKEFEDEQQQLVADVLLFYDSQDPTLRGNVQLIVGNCMRAAIESAGSYHEFIRSKVPPTMQAFLSEDKMLQVVIMRTKNRLGQSLTSGTPFRPSETNIFLNDHSKTTAAPSGTSHLFDAILDRLMLLANNKYWLVQCKLFDVMVQLDYDCIRALGLQGDLFHGDCLDQLLAGLGDGDVRVRNHAGEKLLQLMERSTNDKSARGQPEPKQTVVGDFVNQFVLSSFAVPFDRRSYQLPHHSVERGRTSATIGRVLYRISNLLLKISDKNLQSGIINFLRLFLSKHNPFDYVELWNEYNLINVLLSLLMEMNGHVLDMTVHTDLLRICSQLLVVVVSSRPASTSADYELINKFIIHLLKLLNIYHHLFANITPIVINRVQKTDIFMNTKELQQINCFGFFGSDHACMKLYHQVRSSLESYRMTINAEAGQKLFDYLRAALEALWTLLEMKTLSTMTNGMKFLEEVLRYLQSFLSLQPDHCIRCTRFLLRFIFHANYVNRTAEVAYFRKAACFADDAPNEMPSEEFFVRYYDFCKAKSKPVLAEVGSYVKLFEPLVITCLKIFSKVSSPVQASILEMLCQLLDFNINYQLLDASSAFVESIFKHIEHIERGTVDDSEALMRQVVRFLFQLTGLVREKPLVTIPKIINICDNLLANNTVRRTALASVQALSHEVFLLRPTGKSLAPKVLEEAECSTQKEVVLNMLIKFPDELAVYRIVPMIMSGERLHEGNATNCELDILTAMLQVMREGKLVMKIDRDYNIVLRLMECFSRNVLLESKTILRFVEILYTTISNESCTALQRVIYGELIVRQVFSRTEERFLLHHVGLYLRKARAGIEDETTETTPEGCRTEDQPDEFVQQAVPSLVRVLVQYLRECFTTLEELQLTHNVSEETIQFASDSITRYMDTLTSMIAFHEISRVLAEQIPLEIIHWNTLPEPVVRSLVGLLIRHNFDTELVLSFVRNDAYNVRNDRSVRVLVEVLLEHKPNESKWDRSEIRALLASETHLLVAHFHPLLLCHITDEEFSKQIVRTILTGIEEKLSSVHFTLLEKSPLTTLSIMCNRLTDMLGTTNIVSSRNAALILGHKLDALVQLGAEGLRDSGVLAVLPESDFVRLYSSFTADRRRKFPKLFKTLSQLKPYYEACGEKMKMLSLSTAPNINLQALRDLPVDEGWYLRQMAHHCTGDSYTKPRNIARMLHELKSETKLINLLSSASLNVRLLRDIISVAFESMFHAFRVDCVQFNPHLNYLKVHPMLKVALIVLMRKLADFAAAPSKQEQDTTTMVNCAESVICFLEYLTRLEHLCLFYIEGRLIDRFVKEHLLKSNFFETLLSFGGVCARAVQQEPPENVTRIELYLRCIGAILNQRYLWNELNQNDRYRDSVALYVDVVYTLQERSLVDDQHFVRRRLPEVFQPFVEQSQGCGMDIYLKVIAIAELITDRSVMRKKLSTSGQLFRLIETVTISLLKLDRFYPYALTPVELYDCYQTLDAQENGHPKLPTIPIEHLYDVELLEMFLKRTNIFGYSSRQQFEELFMAMMVLLNRTEDPLFVSLLEQREIKHMCLQAVMGLLLSCYRYPWIGFTEGKFHHSTRNPKIRCDTIGLKKLHNIQLFIPLSNVFYQPNLERRLVITVSDDLHSTDDSSVGTVRFDRNQLSLDYFWEIIESTINQGQGSTGSSPGESLVVRNRRYFVEKMNIDVTSSMQLIYDVLKQLIEDEPALVLPHLVYFCEIVDNREQIYWLNQLLLKLQERVPMEDTLSQQHIIYLLCRLAALLVPALAELTHLCTIIPTYLKSTQLYIRNATLQGLICLLEGLVKTNSSIGALNDELQLLRNVIVNYVVKHGIIEESSGAFSDLHTKLVWTLNFYLIEHTSRFVADCNLLSNSIISANNILKRTTNLEIYLCILNGLERLVISKRVARSLHEKIEKLAIDLVKIDNEMFSLSALKLLVTCVYTSCNEQLESTERCNGIVQDEPDIIVQQIDKIEILFAKIRTTTPQGARVFGDVLCQLIRDLLPANEILTKVFKELMLNQPNPDIIAGVTFQLFRSAIDASYLTLLQEWLLCSLPNFLAFPQVNKSVWCLTVIFLSASLNQHLIKLLPEVLSLPSYQQLNEREINNFIVSARDFYHRLDAGGGQRAKFKEIFQQHDSFVFQSLVQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF66</accession>
    <name>A0A084VF66_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00003809</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01012362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF66"/>
    <dbReference type="STRING" id="74873.A0A084VF66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003809-RA">
        <property type="protein sequence ID" value="ASIC003809-PA"/>
        <property type="gene ID" value="ASIC003809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003809"/>
    <dbReference type="OMA" id="FHFAMNE"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB36610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003809-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="282" mass="31369" checksum="767D79133E4C1281" modified="2014-10-29" version="1">MKRFNFKGLMAPVFTPYSNENGELNIDAIEPYVKMLKAKQVEGVLVNGTTGEGMLLNTSERMLVTEAWKRACSTHGVTMMVQIGGAPFPDVVQLAKHASRIGVDAVLCLPELYFKPKTSENLVAYMKEVAKHCPATPFFYYHIPMFTDVHVHMPAFLNMAETTIENFCGIKYTSGDLEQGSACLKEGRTIFLGADTILCGAVASGFDSFIMTTLNICPEMAIKIIDNMKRGAIEEARAEQCKLNQHIASILEHGDWVSAMKKAFRERYPSLEVGQTRPPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFB7</accession>
    <name>A0A084VFB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003720</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003720-RA">
        <property type="protein sequence ID" value="ASIC003720-PA"/>
        <property type="gene ID" value="ASIC003720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003720"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7559" checksum="CF49EA6BC49F839E" modified="2014-10-29" version="1">MMNAAILIGLGMISSPNSHLKRSRNSLPSRGLPFLFLPRRLNKQANNGKGTVFQGRRSAPGGKGSKKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGA9</accession>
    <name>A0A084VGA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Carbamoyl-phosphate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004178</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012750">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524812">
        <property type="protein sequence ID" value="KFB37003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004178-RA">
        <property type="protein sequence ID" value="ASIC004178-PA"/>
        <property type="gene ID" value="ASIC004178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="15927" checksum="44D3F010A2ECD750" modified="2014-10-29" version="1">MRGGSPRQRIEISTTGTEAIPVPATSATVSISCRTQSHRKQLPKWFSPDQVSVRQLEVAELSLDTVHWTRPLAQVVVLGVQVVLGVSGCGRVMVTFRNVGYGIRSKAVTTYSVLRSKETIPSKPCSQTEPCQKVLPIGHPERIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHB7</accession>
    <name>A0A084VHB7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004656</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01013150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHB7"/>
    <dbReference type="STRING" id="74873.A0A084VHB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004656-RA">
        <property type="protein sequence ID" value="ASIC004656-PA"/>
        <property type="gene ID" value="ASIC004656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004656"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019033"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="277" mass="32081" checksum="9371CD0F70ED5519" modified="2014-10-29" version="1">MTRQNKVPVNLTGFFDIDFTLALIPFWDMGNHAYPTTPEDRPDEARLVAETVYNAERERLECFLDGTDQAPKGAPSVPIFIVYGKRTDAEFLVHNGFVIARNPHTSLKRLFKLNPEDPLHKERSHLLKLLGIPTEGTFTFGYPKLGHVSPELIAFARVSSMNEQELEHYTTMEESQRKELTVYETAHRPDLMNRANLWLAKSMRTQLQGYPTTIEQDEALLETQNRPMNPIRRLLIEYRLEEKRMLQSYVTLACDELKRLMAEIKLGTKQSKQFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJN9</accession>
    <name>A0A084VJN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005494</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013828">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524901">
        <property type="protein sequence ID" value="KFB38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005494-RA">
        <property type="protein sequence ID" value="ASIC005494-PA"/>
        <property type="gene ID" value="ASIC005494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005494"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002154"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005494-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="29856" checksum="0F955FCD72BB703B" modified="2014-10-29" version="1">MPTMLERPASRNSARWQVVCPNPKPSGLKRPQWVGNGQATVGQAASSPPIASALSQTKPPPSPSKHLALEPPSAISGIGGKRGALWRRVWGFRAYAPGVAILENYASNPRLACVHHSHVPGVREVDGPLRGWGRTVPYRDNGSAIATLRKQVAEYQQQLHQSHPAPSSSSSSTAQQPSSSSSSSKHSGDQALLPAASSSGHPAKPSTVSTIGSLLAFFTFAPRLACGSVMMFHPYRRGFYFTSSYQRVKRSLPAHAPACRVESRKAYRKANRATESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKZ3</accession>
    <name>A0A084VKZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006025</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524960">
        <property type="protein sequence ID" value="KFB38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006025-RA">
        <property type="protein sequence ID" value="ASIC006025-PA"/>
        <property type="gene ID" value="ASIC006025"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006025"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012734"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006025-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="335" mass="38002" checksum="399AB3D6AE96C5B6" modified="2014-10-29" version="1">MRFLSVEQTLIDIIEWIYHLRNEVVGDPNAKVILHGLGYGGTLAIWARQRFPNLIDGAYGSAASVIAKVNFFEYGEDMGNTIRTFGHDDCFGVIWRGFRTAENLVDAGLYDHISEMFQSFEAQIFGQATYDAVAQMCAELEADPAETALEVLANFFGRRYAAVDCVPYDFEAQVEGGLNEDVDFPTNAEFGIRQRLYQLCTEFGWFLTSSTGDSPFGTRITYRYFLETCRAVFGDWMTEDIVYEGVRLTNLHFGADDPRVTNVVFVNAEFDPTRLLSITNYTNTFANAFVIDRAVVALDWMTPTDNDPEAMQRIQREIEFYINLWVTDGFGPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL68</accession>
    <name>A0A084VL68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP009606-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF3421 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006114</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL68"/>
    <dbReference type="STRING" id="74873.A0A084VL68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006114-RA">
        <property type="protein sequence ID" value="ASIC006114-PA"/>
        <property type="gene ID" value="ASIC006114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006114"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010565"/>
    <dbReference type="OMA" id="PEKLDWV"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="20092" checksum="92582D4AD13C98CD" modified="2014-10-29" version="1">MFNPYLYQQNLLANSPSKGYDEVYKWDCARWVEAAEGVVPPDAVVGGYEGGEYTYIGRCKHHKTITPGRIIPSRKACVISYGGREHEKHDYQVLCGYQGRFVPSAHGYIPDGALRAGVTEHGKPLYIGLVRLGLTSVVGKVQPDHWCCYISMDEWEKKYLEYEIYVSVHGYRGPLDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLR1</accession>
    <name>A0A084VLR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000447-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006223</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006223-RA">
        <property type="protein sequence ID" value="ASIC006223-PA"/>
        <property type="gene ID" value="ASIC006223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000246"/>
    <dbReference type="OMA" id="IAGWNNV"/>
    <dbReference type="OrthoDB" id="10064757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="1">
        <location>
            <begin position="575"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="652" mass="75066" checksum="9830DB6BC508A685" modified="2014-10-29" version="1">MLKSRCLFALFVRKYPLKQYCCRRIQFSASVAVKKFLDSENDYASHVLQTMQLQKNAAGFPIGIGAPESALNQQLESVDAWHNDPDKIVELLFNIVACIKNETDGTLSIEDRRFDVFVTRFVQTVPNFTDAQLSRALQALAGMGETASIHDPNYLSLWTSLDNECLERIVDWNVEMLLQMADMWYPLRLARQGKYVNKALWKISNRLRKLSPQQLVKTVFYVNLTRVPLENMMDIEVNFSQNFDAFSIDDVAVLCMGFFKTETPIRSAELLEKIYDKLIVSLASVDDIPLTAILKLLRYSSRIPNVASMERLLTALVPEISRLSLLACLHIALLGSDIHLCHTESLELIIEKFHRNISSLRLKDMERIAFVLAHNNVALREARDEALCRDILAEVPNRVAEIVQYPKCYIALLHFLSMKNIYHPDLISAAFDQRFLQLAYNKNIAGAGREAVTLDAFAGINLSEQYAGNRFPPASFRLVCKLTQDYLPNPKYRLTKSDRMLLDIQSTFQAAYNDHCRIVHLLPHYQRPDVLFCFDERTGLALSLDSFMDSVASHEILTREAILKERSQERNLRLVAIVVGSWNCYVRGVKRRTGGYAMKLHQLKLLNYETVEIPWYEWPVFSRDDMQRYLTSKLVQYFPRHSKTSVRLVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM68</accession>
    <name>A0A084VM68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009313-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF725 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006385</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014581">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM68"/>
    <dbReference type="STRING" id="74873.A0A084VM68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006385-RA">
        <property type="protein sequence ID" value="ASIC006385-PA"/>
        <property type="gene ID" value="ASIC006385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006385"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023611"/>
    <dbReference type="OMA" id="ILEQINC"/>
    <dbReference type="OrthoDB" id="7733723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007931">
        <property type="entry name" value="TsetseEP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05267">
        <property type="entry name" value="DUF725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783851" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Protein TsetseEP" evidence="2">
        <location>
            <begin position="105"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="255" mass="26908" checksum="C29873C429C93EA5" modified="2014-10-29" version="1">MKLLLVAALAACFGQLRAVPVADDTALALSSETRAQFFNEFNNLLGGIAKEALESLALAGQNTRSQLQSVQDAIKELETLYNEKVLQELAKYDGALGELGGKVSPCFIAVGQDIKDIVGAASGSAGQCAKETLSRVRQIEQNIEEFISLALDKVHEIVAIGTKCLSENNWIVDQINCALQNAPVAVSIVEEIIKDASELVSQTSREVSDIASDTEQCLAGTVQDAVGEFNTALENVIVCLEAAGGQSDVPAIEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN32</accession>
    <name>A0A084VN32_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00006801</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01014674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN32"/>
    <dbReference type="STRING" id="74873.A0A084VN32"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006801-RA">
        <property type="protein sequence ID" value="ASIC006801-PA"/>
        <property type="gene ID" value="ASIC006801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022231"/>
    <dbReference type="OMA" id="SHARCIG"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000012">
        <property type="entry name" value="Chromosome undetermined SCAF14725, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000005">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="511"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB39376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="660" mass="72952" checksum="D286C55567013D34" modified="2014-10-29" version="1">MEGQFLVRQIYEDDITYNLIEAAVDILNIPAGDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTETNGQLVLHYYSERPGLEHIVIGIVKAVASKLHGVDVEIKIIRRKGDPIEPAAPAATEAKSQQPAAKSPGPVQAVKSVPITSHDPAVPELANLDLATSKSSTALKQPPTDSSSSPSSSAASHGNKLSISSSQNGSNSIPLHGEVSATSKDTNTNCDSSPGQHQQQDQQQPTATAGPTVERSDHFQFLITEISGPKTPTRRSDDKDQQAVYQLVAKEPMISPTTFCKIFPFHLMFNRSMHIVQAGRSVSRVVPRIYEKNCPLLALFEAVRPHLQLSFENILAHINTIYVLKTKAGVMSKSERYLRLKGQMMYIPGSDLILFQCYPSVMNLDDLTKKGLHISDIPLHDASRDLVLLSEKFEAEYKLTTNLEILTDRLQQTYRDLESEKQKTDRLLYSVLPKTVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDAEGAMKIVKMLNELYTIFDELTDSKSNSNIYKVETVGDKYMAVSGLPDECENHAKCIARLALDMLDMAKNVKMGTEAVKITIGIHSGEVVTGVIGNRMPRYCLFGNTVNLTSRTETTGVPGRINISETTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN61</accession>
    <name>A0A084VN61_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00006842</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524979">
        <property type="protein sequence ID" value="KFB39405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN61"/>
    <dbReference type="STRING" id="74873.A0A084VN61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006842-RA">
        <property type="protein sequence ID" value="ASIC006842-PA"/>
        <property type="gene ID" value="ASIC006842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006842"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008041"/>
    <dbReference type="OMA" id="IHFAHIM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB39405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57963" checksum="39256FAE0EC8974A" modified="2014-10-29" version="1">MWLFLLVLVLFVGLVWIYQHFQLRYQFWAKLNVPFMEPSFPVGNVGETLKPTIHFAHIVDGLYRKLKHHGDYVGIYFFRDPVLLVLSPEFARTILVKDFNYFVDRGVYSNEEDDPLSANLFFMEGNRWRNLRAKLTPTFTSGKLKSMFHTIVAVGTRLDQYLGERCVEPTRIDIKELLARFMTDVIGSCAFGIECNSLNDPSSKFRQMGKRMINLPKLKALKVFFAMMFRRQARALGVRFNDKDVSDFFFSVVRDTIRYREEHGVRRDDFMQLLIDMMKKEELDEGLTFEEIAAQAFVFFFAGFETSATTMTCALHLLANHPEAQRKARDCVREVLARHDGHLSYDSIMEMEYIEWVINETLRIYPPVATLHRRTTQPYRLPNGAVLPEEIGVIIPNLAFQLDPVHFSNPFDFIPERFSSRNGLKNNFSYLPFGEGPRICIGMRFGLLQTRLGLAMLLRNYSFGVEESEAANRTLRIDPINLIHGPAGEVWLNIERITSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNE9</accession>
    <name>A0A084VNE9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006989</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006989-RA">
        <property type="protein sequence ID" value="ASIC006989-PA"/>
        <property type="gene ID" value="ASIC006989"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006989"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005224"/>
    <dbReference type="OMA" id="VATQHDH"/>
    <dbReference type="OrthoDB" id="7765360at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006989-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113949" checksum="CD8E36227E8FCA39" modified="2014-10-29" version="1">MSHPKAGSSKTQADIRDVMVQIQRKVSNRPVRNPVPANNQTSRISAEPQQVAIADHAADNDSFAKQIFSQHTNIEQILLEKLPERSEKTRQKYQQMLYERYVQDSAVSGRLADPLHLLRFETRFWAGLFRMATRVPIPTEAAYKEMASSLAKVGEKKICFVDMTRNNVLLEDQRDVIQLLQTSFNNWSGKLGKLQKYLESSQRIREQKAAKEEAKLLQLIKKHSNCKKEWLKFHARLIHDLLGPIEKRVLLIWREFEFDDDALNRKYSVGRYYEDPKIQSCVQRIPKHTAFIRQAPSHTGTERAQLRTPTPSSVSQSYNLLTPIPLRPNIQASETVPVSTVQRNPAPKRPTAQASTAQAPTTQTTTARTPTAQAPNNSQHSNVILESMPDRENDQNINTTNRATEQPANVEKSILNAATEQVRPTKRARTDDHLFTVPLPINFVPKQELSSSTVSLISPAQPNATADTPGYSFDYVKSCTNIYELVVYQRMQNVPNTRLTPARVEKLVKAFYEYFRSTFDRLELPADLRILTPHEQAEQQAKGACRWACEKLGIPIDMDQQQGVVEQPATIVSVSNTPATVAAPDPVQPLVANTVVPRKESQENAQQQQKRPKKQLLFPRPCPIRPANIKYESDSQITSEDIVAGPSSQPPELNQAPQNTPNMDMLSDPDTMSFMPPVCSTQNQDGGSQPLAVLPELPQEQTASESPADENMQSKSPDNVTGVVIKHEQADTSGYEGYVEEIPKSDEVILIHDTDDNFLEELENPERNALQNRLVGLFRTGSDSVAPALTPLFSNIEVTGGPESDETGPYGKSTIGPAHPFDFLLDINIASLRYTERPIRWRGCNELQQKQLTMNLHHRSQGIFRVAIHDHQVGQLLGLLGPGVNAGTSAGWKALTASLAHAGKFRYGRNEPPKEYYRMTITEKVLHLFFDTLPSIPRDGGFVLGLGQDRATFPAEGGTVLLERFNVHRHSKPRKAVSGASEKKADTEEGCEEGESLVQYLLPGVAEAMVELRKSLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP64</accession>
    <name>A0A084VP64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007453</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007453-RA">
        <property type="protein sequence ID" value="ASIC007453-PA"/>
        <property type="gene ID" value="ASIC007453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007453"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10569" checksum="FA0D2950FD348B08" modified="2014-10-29" version="1">MESIWYAKGGREECTIRERSYPFSHLRFFDGDGSERAAVVLALNSLRDRRGIRSERKSAHGPETGAEDETTPYAVFRPTLINSSNTKFLSGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQP3</accession>
    <name>A0A084VQP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007312-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007771-RA">
        <property type="protein sequence ID" value="ASIC007771-PA"/>
        <property type="gene ID" value="ASIC007771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013554"/>
    <dbReference type="OMA" id="ITCYLFM"/>
    <dbReference type="OrthoDB" id="7724958at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="174" mass="20371" checksum="6B62B3576E468D28" modified="2014-10-29" version="1">MERYLRFYIKFQGYMIGALTLLLSVLLTIVIYDSNSFTYPLEEYYDYRFMGSSALVLGIFWFIAGFSFIYGVHYEIKQCLLPFAILYLIDLFLIALRDLVMVWHDRRWYSMVFVNFPAIIMVLYITSYLFMTLIALSRLFSTDPKPQTGDNFMRFNNGIANPAAVDDEDSLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQR9</accession>
    <name>A0A084VQR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Odorant binding protein (AGAP007289-PA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007801</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQR9"/>
    <dbReference type="STRING" id="74873.A0A084VQR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007801-RA">
        <property type="protein sequence ID" value="ASIC007801-PA"/>
        <property type="gene ID" value="ASIC007801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002499"/>
    <dbReference type="OMA" id="CCPMPDF"/>
    <dbReference type="OrthoDB" id="7733457at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054577">
        <property type="entry name" value="OBP47-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22651">
        <property type="entry name" value="OBP47_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759872" evidence="8">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="OBP47-like" evidence="9">
        <location>
            <begin position="46"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="21876" checksum="3567084B0A492808" modified="2014-10-29" version="1">MNPIYGTTILVFLCSSLLASVAPAPSKDACAKGDINTDPFSCCTIPKLLDVAVVTTCFEKYPIDPSTTPTKGSISPTDCMSECIMNSTGIYNRKGDVDSKKLTNVFTDSLPTNSPWLNVVNNAIKECSTQATKKSTEFDKTIASSKKSATKGQLVCNPEASFLVDCIHTTVFTNCPASLRSTTAECDSIWKFLKVCPFSALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRT7</accession>
    <name>A0A084VRT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015778">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRT7"/>
    <dbReference type="STRING" id="74873.A0A084VRT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008299-RA">
        <property type="protein sequence ID" value="ASIC008299-PA"/>
        <property type="gene ID" value="ASIC008299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008299"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024511"/>
    <dbReference type="OrthoDB" id="8069541at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="11213" checksum="1ADAB5E4B170CDCC" modified="2014-10-29" version="1">MMADTPTNTSAHVPPASTSGAGGNGDPSVIPQWKKELIQRRKNLAKTIGAVATQVHDSASTVAAAISASASSPVTPHPRTPTGGGAFPVGSPFYAGAGTKDTSCSGDPPFARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT48</accession>
    <name>A0A084VT48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP002886-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00008689</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525060">
        <property type="protein sequence ID" value="KFB41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VT48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008689-RA">
        <property type="protein sequence ID" value="ASIC008689-PA"/>
        <property type="gene ID" value="ASIC008689"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008689"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022741"/>
    <dbReference type="OMA" id="QNSCQFI"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="141"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008689-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="424" mass="48508" checksum="AE17CAD55007D8EC" modified="2014-10-29" version="1">MRLICWYTTDKHKRDVLLKQNSCQFIVNKPYAVISSSVSFFIPCTIMVFTYFQIFREANRQEKQLALRQGTAMLMHQQHGGGGGRGGTNGEALSGSGSSRTLTTHEVDAEQTPTRDRHLIXXXXXXXXAMMAMTFNFSVQITGSWKFGSFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVAIMLLNTWISPALLSFVPIFAGWYTTDKHKRDVLLKQNSCQFIVNKPYAVISSSVSFFIPCTIMVGSGSSRTLTTHEVDAEQTPTRDRHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYIITSLCGDEACPCPDIVVALVFWIGYFNSTLNPLIYAYFNRDFREAFRNTLDCMFCAWWRRETSPLDINVRRASLRYDCRAKSVYSESYLRPSSQTDRFNSEVGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU93</accession>
    <name>A0A084VU93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009134</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016705">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009134-RA">
        <property type="protein sequence ID" value="ASIC009134-PA"/>
        <property type="gene ID" value="ASIC009134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009134"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15770" checksum="84F72BCA4FE5AD73" modified="2014-10-29" version="1">MGNIQFSSRCALRFDGAGQLQAVLQRADYLQYVTTSHCKRNLKRSDTEHGRSRAPRQALSSPPPSGPASPPAFQSSPRYQSAIASWWTPRPLLSAEQRRKESKPLIQAMAVSDSVSCWRLQPLPRHAKPTIHRSLPNKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV66</accession>
    <name>A0A084VV66_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009704</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV66"/>
    <dbReference type="STRING" id="74873.A0A084VV66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009704-RA">
        <property type="protein sequence ID" value="ASIC009704-PA"/>
        <property type="gene ID" value="ASIC009704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009704"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002675"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000501">
        <property type="entry name" value="Blast:Protein VAC14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="8">
        <location>
            <begin position="450"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009704-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="683" mass="77818" checksum="20416FD8D6008AA3" modified="2014-10-29" version="1">MENAFAPISEACVKALSDKTYDKRKVAALEIEKMVTDFKAKKNMAQVKRIIDVLSKDFVRSNDSNKKKGGLIALAATSIALGKDTERFIEDIINPIMNCLIDSDMRVRFFASESLYNVVKVARGAVLPYFPSLFNALSRLVTDPDQNIKSGSEILDRLLKDIVNESSQTFDLDAFIPLVRERIMVKSSFARQFIISWISVLNAVPEINMVIYLPEILHGLFQILEDPLPEIQRMCETLLAQFLKIIKADPAAADIPKMTNVLIVQAQSSNPLIQFYAISWIKEFVQLSGGEILSFASGIFTAILPCLAFESDAKKNIKDCANAVNLNLLELVSNEEDKQKNLSYLDLNPVMEVLRQYLVHSPVPTKIAVLKWVHHLFTEVHDEMSEHANKLFPVLLRDCLSDSSDEVVLQAIVVLAEIVNSATVKGNDFDQTQYRQFLVELLNLFSENNTFLEKRGTLIIRQLCRLLNAEYIYRTFAEILLEERINLKIASTMVRTLNMILLTTSDLFDLRNMLHDIRNEKSASLFECLYKCWAHCPVSTLSLCLLAQCYQHVSEIVTLFADIEITVDFLVEIDKMVQLIESPIFASLRLALISHSNDNANAQHLSRALYGILMLLPQTEAFHLLNNRLQCVPNYWGQPNKISSKSTNESQCKVKFDELFTYFKYVQDLHHQKRVEKRKKNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV98</accession>
    <name>A0A084VV98_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV98"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009451-RA">
        <property type="protein sequence ID" value="ASIC009451-PA"/>
        <property type="gene ID" value="ASIC009451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009451"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016491"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="14788" checksum="94FB7D1C43CF3D8B" modified="2014-10-29" version="1">MNEDERCHVEASGDGERNEDSSSGDNVSVTIPEASTISNAIDCDGSNLSPGKSSISVVSLRSWTASIGTASSEDLSYDNYTDDDDEGAGSNRRFSSGLSTSPFDLRPSGACGRARAPVVVVARSAKRWRSHRAAPLPVAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVA6</accession>
    <name>A0A084VVA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009460</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009460-RA">
        <property type="protein sequence ID" value="ASIC009460-PA"/>
        <property type="gene ID" value="ASIC009460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009460"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8423" checksum="9BD317BDBAFC02AF" modified="2014-10-29" version="1">MNRSSLYRVPFMQPIGSPRHYNVRRSVALPASRHSTAEALGSIRPLREQSVLWQKRKHARLTIALAVDGGNTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW10</accession>
    <name>A0A084VW10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003626-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009818</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW10"/>
    <dbReference type="STRING" id="74873.A0A084VW10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009818-RA">
        <property type="protein sequence ID" value="ASIC009818-PA"/>
        <property type="gene ID" value="ASIC009818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009818"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002210"/>
    <dbReference type="OrthoDB" id="8110475at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784020" evidence="2">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="48"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="34120" checksum="DB038722F6DD3FD3" modified="2014-10-29" version="1">MATKGVLVLCAIVLGCYLCEVQECQEYIKTIASLNPVPVDRTNEFVTQANGVPAKEAEFPHQVRLGQWLHEDYDDYDDPSFFIRCSGALISENYLLVSGHCFWAVGNEYVSLGRHDYTKNSSLPEIQIKHGTSDSFIEHPNLELKSAHDDIALYRLTEPVNFTSNIYPACLWTDESPLQLDKFTATAFTMGTSVNDTDDTHVAKLLVNVVPNAECNAEYANSTFYKKGLTDNQICVESPVEWKSTCRADIGGLLQTLEKGSKTVYRLYGVESIGHECEENHMKYAYTKVQKYLDWIEEVVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW62</accession>
    <name>A0A084VW62_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein CBG22998</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009880</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017493">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525170">
        <property type="protein sequence ID" value="KFB42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009880-RA">
        <property type="protein sequence ID" value="ASIC009880-PA"/>
        <property type="gene ID" value="ASIC009880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009880"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12613" checksum="642F22281F2A6B99" modified="2014-10-29" version="1">MNQPPFLRLVSFCPRTAQKKREEYEGKGIETGKTGKVTSRFVEPWPVDRRQTTMTVTLSDMIPVRCSWGDDIDGVFLFHVLRSIYTRAAADWVGMKSGFCLRLGIDRNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW99</accession>
    <name>A0A084VW99_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003789-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009921</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017525">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017526">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW99"/>
    <dbReference type="STRING" id="74873.A0A084VW99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009921-RA">
        <property type="protein sequence ID" value="ASIC009921-PA"/>
        <property type="gene ID" value="ASIC009921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009921"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023413"/>
    <dbReference type="OMA" id="MWRVAEP"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045661">
        <property type="term" value="P:regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="84"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="46460" checksum="C47D80DEA5BB8171" modified="2014-10-29" version="1">MFSFFFRPFLCSPGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLEVMTLNPMCEMVETAQGVPLTVTGVAQCKIMKADELLGTASEQFLGKSVKEIKMTILQTLEGHLRAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLQSLGKAQTASVKRDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNSRMYKLQKANFDQEINTAKAESQLAYELQAAKIRQRIRNEEIQIDIVERRKQIEIETQEINRKDCELSATVKLPAEAESYRVQAIAEGKRTQTVEVARAEAERIKKIGAAEAYAIEQVGKAEAERMRMKANVYKMYGDAAIMNIVLESLPKIAAEVAAPLAKTEEIVLIGGNDQTTGDVARLVGQLPPAINALTGVDLSKVLGKIPGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWP2</accession>
    <name>A0A084VWP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001798-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010079</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017679">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWP2"/>
    <dbReference type="STRING" id="74873.A0A084VWP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010079-RA">
        <property type="protein sequence ID" value="ASIC010079-PA"/>
        <property type="gene ID" value="ASIC010079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010079"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022600"/>
    <dbReference type="OMA" id="NEIKCPS"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784139" evidence="4">
        <location>
            <begin position="25"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="329"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010079-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="603" mass="66264" checksum="32D760C11FD9AA12" modified="2014-10-29" version="1">MVCERSKLLWAVLCFTTLVTSTSGGFSRDRRKVCNYYEWKCSSGQCIESHQQCDGVIDCKDGSDETSKSCAFIRCPSYAFRCQYGACVDGTALCNGIRECADHSDEHVHCPGNNGTLIASHGNCSNTEFSCRSGVCIPADQVCDGQEDCSDGSDETQQLCSLVFCPSFSFRCSYGACIGGYSKCDGIVDCRDGSDEDELLCGKPFPSTTPKQMITATSTTTTSTTTAAPVVVTGPPGSCQGKSVKKYCSEIPINGITIEPFCEYQRRQITCKRPLPPTTKVRIGCRVGYQKPSEPVNETLTCNDGTWDSSVFRCEPVCGTATPDAEAYIIGGRNISIAEVPWHVGIYKNLNDASLNDARSADWQYACGGSILTERLIVTAAHCFWATEGFFDKRYFRIVAGKYRRELSAIEAQPVQMFQIHEILHQPQYQDFSGYYNLDIAIVVLSDFISFRTYIRPICLERNLRTESEKRIKPNSFGRVAGWGFTTNTGNLSTTLKVIEIPTVDYVTCREYSPVAYRPFLTGDKFCAGDPRTGTGVCQGDSGGGFALSKEMDGDLVYYLYGVVSSAPRAANGGCDNNKYVAFTEVQNYIPMILDAESRYPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWQ0</accession>
    <name>A0A084VWQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010088</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010088-RA">
        <property type="protein sequence ID" value="ASIC010088-PA"/>
        <property type="gene ID" value="ASIC010088"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010088"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010088-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="226" mass="25314" checksum="A9659ADFC6B48BD6" modified="2014-10-29" version="1">MLLVSGPIGAPGFVEDTLPQVASGGCYRDEWMLPVLPNRISFPNLWSRRREGRGWISVRSFQRAVPFRGRNIKRRLRFRSLAVTVCVGFKPGMVTLAAVEMKPERDELLYALISSRPVTIPARLSCKVQGGRDRRVPSHFVSFLVRAALMRRPFNRRIVMPSEIMLVFARKNPHGNGEGRGGKGQEIFNYTNTQDKLLSFQSSATPAIGLGRFHNPSAGAIFAKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYA0</accession>
    <name>A0A084VYA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010814</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010814-RA">
        <property type="protein sequence ID" value="ASIC010814-PA"/>
        <property type="gene ID" value="ASIC010814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010814"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6324" checksum="227B567B6FFF19EC" modified="2014-10-29" version="1">MDIEISATIATCTGSGSSGAAFEAHQGGGIAAIGKRRISASKQPENRKRPAPSKRLLRCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYH0</accession>
    <name>A0A084VYH0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00010686</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01018366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYH0"/>
    <dbReference type="STRING" id="74873.A0A084VYH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010686-RA">
        <property type="protein sequence ID" value="ASIC010686-PA"/>
        <property type="gene ID" value="ASIC010686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010686"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013780"/>
    <dbReference type="OMA" id="CIHVDYT"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000024">
        <property type="entry name" value="Arginine methyltransferase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF122">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="355" mass="40026" checksum="10E853377849F91D" modified="2014-10-29" version="1">MDNTEEADPGAYFDSYEDLKIHELMLSDEPRQTAYQNAILGNRQLFAGKTVLDVGAGTGILSLFCAQAGARKVYAVEASNLAHLARAVVKENNFEQVIEVSECKVEEFRLPNDERADIIVSEWMGFFLLHEGMLDSVLYARDKFLKPNGLMFPNTATIYIAPCSVPSRFDRWENLSGVSMKCFGRALREQCSSKPEVLTVASEHLLHEGHVMTWLDLKEVTSEELNSIEAKEVLVAQREGKLQGFCIWFDCTFPAAESDEQMSSEVILSTNPSAPETHWKQTVILLPEQACEELEARDPVAFSLTMTRNQETNRRYDLQLTLLDAETEEHNLPCECQMTKCILMKAHLDTMQVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYH6</accession>
    <name>A0A084VYH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010693</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010693-RA">
        <property type="protein sequence ID" value="ASIC010693-PA"/>
        <property type="gene ID" value="ASIC010693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010693"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13974" checksum="A62914AE226465AD" modified="2014-10-29" version="1">MRDRKEEDKVDSNMRLILLKLQIQLPIANGSEERKEGTALSRDCVRVVCRTLLHMPLSLQQHHPGGALCLLVQLNRPIDPGNPVPFPRESYDHEKATRAMKSHRETLVTLAKMAPGTPPLGAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYN2</accession>
    <name>A0A084VYN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010757-RA">
        <property type="protein sequence ID" value="ASIC010757-PA"/>
        <property type="gene ID" value="ASIC010757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010757"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003749"/>
    <dbReference type="OMA" id="AQEQCGP"/>
    <dbReference type="OrthoDB" id="7686329at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784027" evidence="2">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="481" mass="52019" checksum="3BCCEBC94825A08D" modified="2014-10-29" version="1">MLRLTHVVVLVALASVVLAGPTVRKDEVTNVVTDAEVAATKPASPTVPTDQKLVTVPVKLPTAADEQSSEPTTVKASEEVEPSTTTSPEVSTTTTVVTTSSVASTSGVSFTKPPRKTITFDQRQEGKYNIRADLENFVIVVVPSGSSSGASLLDLLTRSAQKKDAYHHHHHHHETRKSNGKRKNNKAQYAGAPKKKVPQGLVTPEVIVLDESNQRSGQLVAEEFIEGRTPYKVDLSSSARSADDDSGHDTEPHQQQQSFRFSVEPSEGRSSGRVRFPTVSSGNYAPSSSDVSSGRALRRTADESEFANTNTLVVAASSATNHYHQQPNPTNLPGDGAQRHHQQQLPTVLLADPPSILLPLRPAPRTANGDREDHGNQARPSAQGLANHSHLPSSFDSLEYAPLRSDVDMKQLQLQPDAEGDSDNDNGAVAGDHYEDLAEQRQRPDQDIGGGWDELRLLGAQEQCGPDRKRDSYGVCQFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYQ9</accession>
    <name>A0A084VYQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010788</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYQ9"/>
    <dbReference type="STRING" id="74873.A0A084VYQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010788-RA">
        <property type="protein sequence ID" value="ASIC010788-PA"/>
        <property type="gene ID" value="ASIC010788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010788"/>
    <dbReference type="OMA" id="VAYPYSY"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685:SF2">
        <property type="entry name" value="825-OAK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35685">
        <property type="entry name" value="825-OAK-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784292" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010788-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="11855" checksum="E5A214B45DC4F7FB" modified="2014-10-29" version="1">MFAKVFVFVAIAVACAAGKPLTAAVVAAPAVVTAQSSQVIARNYNGVAPAVVSAAYTAPVAAAYTAPVAAAYTAPVAAAYTAYSSPFAAAYTAPVAAAYSAPLAAAYTASPYASYYPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0D8</accession>
    <name>A0A084W0D8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001189-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0D8"/>
    <dbReference type="STRING" id="74873.A0A084W0D8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011410-RA">
        <property type="protein sequence ID" value="ASIC011410-PA"/>
        <property type="gene ID" value="ASIC011410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011410"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010010"/>
    <dbReference type="OMA" id="IRRTNPC"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784167" evidence="6">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011410-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15224" checksum="40B9847F76F836B2" modified="2014-10-29" version="1">MSVRVLIVFATIALAGVSQVVAQQEIAELPEVKGYKLHCIEASGITEASAKKLSAGEAIKDPDQPTKCFVQCFFQKLRLVDENGVVLKDKLEAFLTRLMDADKAKDYVKQCDIRRTNPCDTAYAIYDCYLGKKAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1K1</accession>
    <name>A0A084W1K1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00011930</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1K1"/>
    <dbReference type="STRING" id="74873.A0A084W1K1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011930-RA">
        <property type="protein sequence ID" value="ASIC011930-PA"/>
        <property type="gene ID" value="ASIC011930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011930"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004738"/>
    <dbReference type="OMA" id="ICPGCNI"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001031">
        <property type="entry name" value="zinc finger protein 341 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="13">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB44095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="654" mass="74438" checksum="803DB6A667F07DC5" modified="2014-10-29" version="1">MFAIASGINSEQKLLLYESKVCRLCGDKNENGRPLFQSSDSNEQCETSQLINRYLPVVVHDDGVSPRWICPGCHIQLESTAQFFEMIFKGQRIITELLQQERQAQEAQQSASKLARVDDLGQLYDTLDQAKWNELFGKPDLEVTDRDNLLVPLELFELEDLLKQGDNQPEQPEAYVEQAAQQDDGNVAKHSEVKSEELPRHVAEELTGECQGAEKDWIVKSEMTKLNARVIGYIQNQNKTEIGSLVVMEGASKKKRTNTKFVCDICSKIFTHEFPYIKHRKSHSILFECSVCLVKFGSSVKLTVHQQETQHNGKGIVEGLPLASNEGDTEQSEPKGNAYACDNCEDTFPELTTVLKHEETVHAGENRSFVCSACGKEFREKYLLQKHQETHVEERPHGCGVCGAAFKTSSSLSKHTQSHAEKKRYQCTMCTQGFAYKTSLDLHLNWHNGVKPYECEFCSKRFSQRGNLKEHLRVHSGDKPFSCDVCPATFSTSSQHRLHRRRHTNDRPHGCELCSKTFVLLENYKTHMRRHRNEKPFACEECTRAFTERWALRKHIRTHTREKPYTCNYCAKPFSDSSNLMRHVTTIHEKQPKPKKKQGQPQTIVTEPSGIPDVKPIDGTLPELGVVIDETDTLVSLTEDEILTLDTTVYMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2K3</accession>
    <name>A0A084W2K3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012233</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019622">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2K3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012233-RA">
        <property type="protein sequence ID" value="ASIC012233-PA"/>
        <property type="gene ID" value="ASIC012233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012233"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13795" checksum="893C24D16C1C1B2D" modified="2014-10-29" version="1">MFSHRMSTIHLTFHELAPPDDAERFVLTAADNPTVWQVVMVKGEGTDDEKCVFPTRRIGCVAVRCCAESAQNPTRERTLDPSSTNFASCSRAAPCHTMRPHQHPSLSLSHTRRCFVNERKNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W322</accession>
    <name>A0A084W322_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012499</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W322"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012499-RA">
        <property type="protein sequence ID" value="ASIC012499-PA"/>
        <property type="gene ID" value="ASIC012499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012499"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7064" checksum="38C8242F9C9C1B6C" modified="2014-10-29" version="1">MRHDLAGGGRFSGAPRLDDDDDRKTPWAAVRVPSIICWHAGEKIPVATVILPGTDGIYVRPLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3R2</accession>
    <name>A0A084W3R2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00012765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01020113">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525294">
        <property type="protein sequence ID" value="KFB44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3R2"/>
    <dbReference type="STRING" id="74873.A0A084W3R2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012765-RA">
        <property type="protein sequence ID" value="ASIC012765-PA"/>
        <property type="gene ID" value="ASIC012765"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012765"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018809"/>
    <dbReference type="OMA" id="VPLCTIN"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000038">
        <property type="entry name" value="Myotubularin 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="12">
        <location>
            <begin position="172"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="387"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB44856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012765-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="599" mass="68930" checksum="540AEBE6372033D3" modified="2014-10-29" version="1">MEHHGTDFHRSSNSLDSDSKSSSLNSKHGMDTIVANESGFTYLSGENMQDRKNDVSYICPYSGPAIGTLTITNYRLHFRSQPASDKDPVIVVDCPLGAVSRIEKVGGASSRGENSYGIDIFCKDMRNLRFAHKQENHSRRTVFEKLQLYAFPRANEGHLFAFNYREKFTEDGWTVYEPVAELRRMGVNSANNDTWRITRLNEGYEICDSYPSVWAVPKTAKDDLLKQVAAFRSRNRLPVLCWIHPKSLATITRCSQPLVGVGGKRSEADETYINLIMEANAQSDKLSIIDARPSANAIANKAKGGGYESEDAYKNVELTFLDIHNIHVMRESLRKLKEICFPANDDHKWLSAVEGTLWLKHIKCILSGAVRIVDRIENMRMSVVVHCSDGWDRTSQLTALSMLLLDPYYRTLKGFEVLIEKEWLSFGHKFEQRIGHGDNHHSDADRSPVFLQFIDCVWQISKQFPHALEFNEYFLITILDHLYSCRFGTFLYNTERERVTNDLKNRTVSLWSFINSSHEEYRNPLYGGLSNYLTSMPVQTVLRPVVSMRHIRLWKGLYCRWNPSMRQQDPIYQRTRELLALQAELIRQLEDCRTERALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3V8</accession>
    <name>A0A084W3V8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP009003-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020162">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3V8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012814-RA">
        <property type="protein sequence ID" value="ASIC012814-PA"/>
        <property type="gene ID" value="ASIC012814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012814"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016644"/>
    <dbReference type="OMA" id="RDQWRPC"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF13">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784449" evidence="2">
        <location>
            <begin position="24"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="489"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="864" mass="99526" checksum="E0E06A236AEB1194" modified="2014-10-29" version="1">MIGVAKVVLICISLSLLVPVSIASTIIIVEDAKACYRRVLAGKRVAPHWVRRTLICERVEDCQRECGDERRFSCEGFNYRLDPTGRGQGDCELIDQPLSQIDLYSSPHQRDSNLIRDPDYDYYERDRSATSNCRPSCKDCMVKPFRPTLEFVRPTTYRPHHPENYKPYPSEPHPYEEDRYKPSITAIDKYRPPLYARPDFERYSPSSSYYPPPPPPLPSPVESYRPSISYKPQYGSEIDRYGTLDHGFFKVPYDRHEYPKPIHHEDIRPVHRPRHPYEDRDSPPPPSGPHISTGQQYGHKPNTFIPYLIGQNIHKNGGVYGGSYGPSFNTDSYKSISDYWGLRNEIKRYDTPPSFNYFELRNDHHFDDNNVWSYGGSKYGYEESYPSAVVPFDRDQHQHPXXXXXXXDCGGGARECATPSRVSGGLTFSYRYSAVSRENCLLCDRPFNLLDFYADLEPDRDYDIYSMSDDAKTCHPELGPPRRDYNAQCFIRVIDSGRFFKSIVRDSLTVRSIGECELECIKATKFTCRAFTYSFGPNSINAVIDNCQLSDWPVRDMDKDRHLVPDETFDVFERASYGQGCEIQPIIDDKHHKKFCYLGYGSPAKLLSSAIKKVTSVNTELDCKNECIRLRESTHFKCLSFSFSSQASTYNCEMSDLDQSELKLGVHYAHTNDRDFWLFAWNPFDYTCRDKITTISSGSTTRMNHDRRIDIFREPGDGSWRQYTVSGKPCRLGTKCERNKITGFYSCEIEGGEIGSWDYCCKAEHPCGYSQGFDYPWCYVGDAPDQWRKCSDKYFPKKQHDSRYQNKNKKGEIYQPPPKPGGLRHLDDVTAPAELWPVTYLYEKGPPNATEISSNVIDCKKDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4H2</accession>
    <name>A0A084W4H2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013037</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4H2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013037-RA">
        <property type="protein sequence ID" value="ASIC013037-PA"/>
        <property type="gene ID" value="ASIC013037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013037"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11927" checksum="4C8797E15A9250B2" modified="2014-10-29" version="1">MGSKKEAEGTRSHKIADTQEERKQELRSFRCSPREGPSKKPATDTNAQEKLTLSMQTNTFYFHLELQARDAVHLQVRDTRQKETHNSRDKLAPYDFTRYLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W551</accession>
    <name>A0A084W551_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-actinin, sarcomeric</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">F-actin cross-linking protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020488">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W551"/>
    <dbReference type="STRING" id="74873.A0A084W551"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013295-RA">
        <property type="protein sequence ID" value="ASIC013295-PA"/>
        <property type="gene ID" value="ASIC013295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013295"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017112"/>
    <dbReference type="OMA" id="QQRWITV"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000148">
        <property type="entry name" value="alpha-actinin, sarcomeric isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="792"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="897" mass="103597" checksum="F1587812C985E353" modified="2014-10-29" version="1">MMENGGYVGQYGDDGGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDNIEDDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYSKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQSDSTLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDITNAWKGLEHAEKSFEEWLLAETMRLERLEHLAQKFKHKADTHEDWTKGKEEMLQSQDFRNCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCASVNARCQRICDQWDRLGVLTQRRCQGLDEAERILEKIDLLHLEFAKRAAPFNNWLDGAREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNVIIGLVRDAEAIVKQEQVPGGLVNPYTTLSADLISRKWSEVRALVPQRDQTLANELRKQQNNEMLRRQFAEKANAVGPWIERQMDAVTAIGMGISGSLEEQLHRLKEYEQAVYAYKPSIEELEKIHQSVQESMIFENRYTHYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGITQEQLTEFRSSFNHFDKNRTGRLAPEEFKSCLVSLGYSIGKDKQGDMDFQRILAVVDPNSSGYVQFDAFLDFMTRESTDTDTAEQVIDSFRILASDRPYILPDELRRELPPDQAEYCIQRMPPYKGPNAIPGALDYMSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5C6</accession>
    <name>A0A084W5C6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013351</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5C6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013351-RA">
        <property type="protein sequence ID" value="ASIC013351-PA"/>
        <property type="gene ID" value="ASIC013351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013351"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002426"/>
    <dbReference type="OMA" id="NRPTVMN"/>
    <dbReference type="OrthoDB" id="10638701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF0">
        <property type="entry name" value="DAEDALUS ON 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013351-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="317" mass="36399" checksum="B2BF9130236D33D5" modified="2014-10-29" version="1">MAEVPKIGWTFVLSLVGFLIVCLPRDTSGAKKPVPLQFSDLDVFSDEPKPFTVRVTKFVCVDTPYEVSELLQCKTILRRNRPTVMNITLRVPGVLNKIWLRIRTYYRFTEYQSVPFEVVLEACEHLRHPSSDALTRHVFAVMHATIPQVMHQCPHGNTTYNVSVWLEDRFFPQSTPAGDYRQDIRISTPQNKTIFAYAAFFSVRRKDIPKIKALSSLNFLTVPKLEQTEKGFRVIGKDYAATFERFVHPEIEHDNPDAVTEQLAKDLRRLDFDLTLVKSKTHYWKHSKPATTIIDAGKKNPKDDEIKQSASGNTIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5H2</accession>
    <name>A0A084W5H2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013404</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020636">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5H2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013404-RA">
        <property type="protein sequence ID" value="ASIC013404-PA"/>
        <property type="gene ID" value="ASIC013404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013404"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013404-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9385" checksum="2D1F014D5A862D27" modified="2014-10-29" version="1">MTRCRRRCPSLTKATSTKGAGCVCRGVDRGLHPFCRLGQLSIGARTVVADRAPQQVHRKAPTRFGFWHSGETRAALINCCTGNLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Y4</accession>
    <name>A0A084W6Y4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013943</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021046">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Y4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013943-RA">
        <property type="protein sequence ID" value="ASIC013943-PA"/>
        <property type="gene ID" value="ASIC013943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013943"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10996" checksum="E65B54D031C2BE50" modified="2014-10-29" version="1">MEKAVVRVQFVSFEQTRTPMPRTFDPCERLRSLAEKENSNPIPRRPTTTKRGTTRMKSRKTQRSERLCTGRLFIHIHISFRPVAPFPPSRAGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7B4</accession>
    <name>A0A084W7B4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">12S rRNA N(4)-cytidine methyltransferase METTL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methyltransferase 5 domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Methyltransferase-like protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00014086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62524"/>
            <dbReference type="Rhea" id="RHEA-COMP:16109"/>
            <dbReference type="Rhea" id="RHEA-COMP:16110"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:62525"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7B4"/>
    <dbReference type="STRING" id="74873.A0A084W7B4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014086-RA">
        <property type="protein sequence ID" value="ASIC014086-PA"/>
        <property type="gene ID" value="ASIC014086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014086"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003213"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023268"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.170:FF:000002">
        <property type="entry name" value="Probable methyltransferase-like protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="443" mass="49892" checksum="D4597E10C3C89DC4" modified="2014-10-29" version="1">MSQHYKKFLSLLERWPLDKSKVGRDLGQYLRDQLSAVLGTSNIIAVKDERLNRQFRSLENIVNDVHAKRHPRTLNSTATGLSGEQCREVLSTETKITRQKQAAPHLPVMTTETIQFLEPKQDEVFIDMTFGAGGHTRALLEASPGVTVVALDRDPHAHQLACDMAKEYPGRLIPVLGRFSELPSLLRTLDGYDRQRFFNGILFDFGCSSMQFDEASRGFSIAHDGPLDMRMDKDRCPEQLSAAEVLARIQEQDLARILKVYGEEKQSKKIARAIVNARLTVKRIETTAELASIVAHCLSQGEPGPAAFEYRQDKLRRPAHVATKTFQALRIFVNNELNEINYGMVLAKHLLRTGGKLVTIAFHSLEDTIVKRHLTGHVVDDVASRVPLQLISHTLAHETDTMQEVMKPNWRQMTKHVVVPSDEEVAENPRSRSAKLRAAVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7N2</accession>
    <name>A0A084W7N2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014232</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7N2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014232-RA">
        <property type="protein sequence ID" value="ASIC014232-PA"/>
        <property type="gene ID" value="ASIC014232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014232"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="12909" checksum="71298873D099EF3F" modified="2014-10-29" version="1">MWLIKIQVCLCAEKTCRSPVMLVPVRWRAVRRRYAPSVRPNQDNLPPVGRTAASEATFHFVSSSGNGKSKSHKIANTGVEVTRRDRFTSNKGGEATAKMHFAQRTNDAVPSRGKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W864</accession>
    <name>A0A084W864_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014405</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021373">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W864"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014405-RA">
        <property type="protein sequence ID" value="ASIC014405-PA"/>
        <property type="gene ID" value="ASIC014405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014405"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7601" checksum="38FD99FE4971EC35" modified="2014-10-29" version="1">MANERPHATVSNVVTLQVQTIWSVNRTKANGKRGEQDAMTHRIGGIVTDAGRERAKRRRRGCAFPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8F4</accession>
    <name>A0A084W8F4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010649-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014488</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8F4"/>
    <dbReference type="STRING" id="74873.A0A084W8F4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014488-RA">
        <property type="protein sequence ID" value="ASIC014488-PA"/>
        <property type="gene ID" value="ASIC014488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014488"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015659"/>
    <dbReference type="OMA" id="WAGHACI"/>
    <dbReference type="OrthoDB" id="7732635at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000002">
        <property type="entry name" value="AGAP000641-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000003">
        <property type="entry name" value="AGAP010409-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784502" evidence="7">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="426" mass="48186" checksum="E24D57476E414617" modified="2014-10-29" version="1">MRQRMALSYALVVLAMVMMGAHANDTKGVVIEKSFLQSVQDCVEYLRIPRQRLAQYLAYEFPPDEETKCLIYCVGTDLRWWNNTCGLQFPAIVNFFQPVLGDRQYEKRTKECVERTMRSGRELNSCCQAYETFQCYFKEFGNLVTCPQYVPATKLQATQAALDCLTMLRVPVDLLQCYSRGNVPDVPETRCMYHCIDLRTGLYNSETGVQLPRFYVRDLAVDDLRYLSKETKVCRDRIRQSGCDVCSEVYQTHQECLAGLGENGYTSGLITEAAKLALTNLGVGCADQVEPVREQGYSYASYQRVEVPCQACASQAPVAVHPPPPDHASFQPARKQPCSCEDKPLNSVLQSRLYQTSEVDLFKPDPFAKRQPANHRQQMVYYPAPEVSPSPQTPSPQKPMFSTFSGRANGQRPHGPYPCTYNPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8F5</accession>
    <name>A0A084W8F5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010650-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014489</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8F5"/>
    <dbReference type="STRING" id="74873.A0A084W8F5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014489-RA">
        <property type="protein sequence ID" value="ASIC014489-PA"/>
        <property type="gene ID" value="ASIC014489"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014489"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019807"/>
    <dbReference type="OMA" id="DAPETRC"/>
    <dbReference type="OrthoDB" id="7734701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000002">
        <property type="entry name" value="AGAP000641-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784689" evidence="7">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014489-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="438" mass="50395" checksum="A7CFCB5B371ADA4B" modified="2014-10-29" version="1">MGCAMLLTLAVALAGCAVVKSEAQDGTHLYLEKSLSQAMHECMEYLQIPANRYDDYASHRFPCDAETKCLVRCVGLNLRWWNDTTGVQTALMANFFQPDPTDTDYARRTAKCLELRLAQSDPSECCSLAYESFMCYLQHYGNLVPCPQYLPEDHSRYVRMAYDCINMLQVPEVLLHSYSNGLIRDAPETRCLLRCFYLRSGVFNSETGFDLRRLYTRDYQHADDVRYLASETYAKLNNLRATGCDECTEVFLAYRDLLGEMGNAYYEDGVLRDAAVLALKDGYCDKRNHHEPLNEEKKQNPKKYHKKTPTKVHYPKQDEAEVTTRCHEKTYEEATTTPKYYEQPTTTPCPVKHQEVPVTTYTEPTMTTHCPPKHHEEPTTNMPREEPTTTTLETSTPVVFNYKQRNCENCGKMFQPGGCKFTCPNCTKSFTKYGRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8S8</accession>
    <name>A0A084W8S8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014669</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8S8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014669-RA">
        <property type="protein sequence ID" value="ASIC014669-PA"/>
        <property type="gene ID" value="ASIC014669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014669"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8153" checksum="CDB126AED80975CF" modified="2014-10-29" version="1">MNVGGCHPPPTASSTTPLRNAERRRTTVESVCERRSLTPDPQSSIPGLMRMPASITRKRSTIDKKHHDSRDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8V1</accession>
    <name>A0A084W8V1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBM20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8V1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014551-RA">
        <property type="protein sequence ID" value="ASIC014551-PA"/>
        <property type="gene ID" value="ASIC014551"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014551"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003155"/>
    <dbReference type="OMA" id="RWWFLEE"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carb-bd-like_fold"/>
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        <property type="entry name" value="CBM20"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014551-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="13187" checksum="A8320A5E5F731D27" modified="2014-10-29" version="1">MQRWWFLEENGEAKDSPSSSSSHAQQQDPTGKRQKQPKQAGDRRHTFRVLVTYDLLKDETVAISGSCETLGSWDPQQCVQLHRENGKERMPENRGYCGRSGCEFIDNKFWASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8W2</accession>
    <name>A0A084W8W2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP009849-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014563</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB46656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8W2"/>
    <dbReference type="STRING" id="74873.A0A084W8W2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014563-RA">
        <property type="protein sequence ID" value="ASIC014563-PA"/>
        <property type="gene ID" value="ASIC014563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014563"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004529"/>
    <dbReference type="OMA" id="VPRIHLC"/>
    <dbReference type="OrthoDB" id="9981647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784392" evidence="10">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="85"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014563-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="351" mass="39269" checksum="8692B54AF01E4995" modified="2014-10-29" version="1">MERCRAFSVCCAVILVLLPTSIRANDCTLDVGSGGKVKGVLVPADQCDTFRDLRTNELHSAIANGSTTVCCPVFQNEPNCGRISVYDGVFSHDSRESQLDQFPWAVVIMKRWVSTTICSGSLISRQFVLSAAHCFVTSRKKLLPEKYRVRLGEWDLNLAEDCQYVEGRLACNDRPPKDIPVQTIVSHQLYDYKSRDYLHDIALLKLIHPAEYSALISPVCLPNWSKDEPMIAGRSFTATGWGRTRSFMALRRKLKIHMKGHNITVCRRAYSMPAPEVPQLQLCVGGERNRDVCFGDSGGALMRRGDDVDRWTQVGIISFGADKCGKGMPGVFTNAAFYLDWIQRVIHDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W905</accession>
    <name>A0A084W905_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W905"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014695-RA">
        <property type="protein sequence ID" value="ASIC014695-PA"/>
        <property type="gene ID" value="ASIC014695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014695"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784459" evidence="2">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5490" checksum="037112CC1ED2A207" modified="2014-10-29" version="1">MNLKLLFALLFTVVAVMMGRTGAVSVESVESTPSVESVESAESVESAESIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H1</accession>
    <name>A0A084W9H1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014872</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9H1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014872-RA">
        <property type="protein sequence ID" value="ASIC014872-PA"/>
        <property type="gene ID" value="ASIC014872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014872"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6148" checksum="AE3DBB772DF91B71" modified="2014-10-29" version="1">MPGAANPPTDGRTKFDHAGKAEVGDTLTPNERLSWTSTGLQFSVLYAAYTPCAYRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9N6</accession>
    <name>A0A084W9N6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014941</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9N6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014941-RA">
        <property type="protein sequence ID" value="ASIC014941-PA"/>
        <property type="gene ID" value="ASIC014941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014941"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5863" checksum="8A9B452D959EB2D1" modified="2014-10-29" version="1">MPSKADRSANRRPTFPSRFNDMRAITVPPLLDDATATLEQQQLMVVRAIHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA45</accession>
    <name>A0A084WA45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AGAP005714-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00015134</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022036">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WA45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015134-RA">
        <property type="protein sequence ID" value="ASIC015134-PA"/>
        <property type="gene ID" value="ASIC015134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015134"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015837"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017200"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017274"/>
    <dbReference type="OMA" id="LRGYCFD"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000119">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="727"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="893"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="934"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1102"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="19">
        <location>
            <begin position="1241"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="18">
        <location>
            <begin position="1455"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1608"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1807"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1866"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1628"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1872"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1262"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1888" mass="208985" checksum="3B04DB26FD82D659" modified="2014-10-29" version="1">MLQMFCAEWQPHSRNSALPVRKVFGVKVCASCIQLGGKFDPGCVGMFVCVPSKPFFLPGAPRNDTQGQGAAAAGTNGKRKPGQKGQNIQEEPDIEPELAARLDLSCMSQGLIRAPEIDNGYVVKYNRRKKNGNIFLVAYYECDDYYELQPPELDRLYCSSKRWIGKRPECVSTRTGLEDDEEGEDEEEEEEEEEDYEEEGEEDSEQPSEGDERVHELPTTSSTAMPTTSMLNEHDHHRSPPGSGGGSNEEEGQEEEEDADADETEEDENARRDATEDTEDQIANTDQEKISKVVSSPSTTTTTSKTTIVAACGSDRGGCDHECRMIYHGNEVEPVVECSCYRGFLLDARDGRTCHDIDECAENNGGCEQTCINKPGSYDCACEPGLQVDTLNGHTCIDIDECDNEDVAERCAGGCENTFGSYHCLQAVASERTPIHQSNEEDDEDVEEPDDEDGEDGDADGGESDKHAEEHIDECLEEEHGCDYCQNAFGGYQCICPEGYELADDDKRCQDEDECAMGRDEEGEGGTICSHECHNTIGSYECRCPEAFHLNNDRRTCVRDFCQDLYENPNKTRCSHECVDEVEGFRCNCPEGYLLDEVDQKTCRSAYSCDEGQQKRCDPGRCRRVDMNSGDYRCECPEGYVQSDHSCHERDECQLGRHDCSHECHNTPGSYRCGMVLGEDGRTCEDVNECHEGNGGCAQSCLNFEGGYRCGCFEGYELEADGRNCVDRDECAAARGGGCDHNCHNTPGSYYCTCHAGYRLAENSRTCMDVNECEDSNGNCSHVCINLLGGHQCSCPKGLFLQEDDRTCDFVDECALNNGGCSHTCHYEYGVVSCSCPRGFQLESEHQKTCVDVDECADRNGGCSHDCHNTPGGHECQCPLNYELRHDRMTCQDVDECVTDNGNCSNICINLPGGHRCSCEIGYELDDDQHTCIDVDECRDGSHDCSHHCVNVPGGYECECPTGFKLGRNRLSCEDVDECTALPDGAGCEHHCVNTIGSYHCGCADGHQLSADNRTCSDVDECSDGVKRCTHDCVNKPGGFECLCPSGLRLDIDKVTCVDIDECRVNNFNGGCSHICENTAGSFECRCPDGMLLGEDQATCTDIDECAVLNGGCSQLCINRDGGYRCGCHPGYTLMEDNKACEVSNPCALRNGGCQHYCSLKAGQPVCSCREGYTLNKTNQASCVDHNECLQQKDNNCQQRCVNLDGRCVCPVGFKLTQDRKNCVELKDNCKPFEAPPNSEIRCSRSRHKAQLFYRSKCFITCKKGYKLHGPAVRHCNGTGEWDEGESICVPLACPRLTRPENGVILPVACTAGKIFANERCVLHCKPGFKPLAKRTAVCNLNQTWVPNDNLACVAITGVAKQPTTPATPAAIPIKPYIQCPPDIHEVLPLGQYTMKVRMERPKTNVDWHQYVDSHPPWGKQLEVELPAGETTVTFRARSPTSNVNDVCRVVIRIRERKPPSVLHCPESFEVQLEASETSRSVFWTEPKFESQSEIKQIYKSNTPGQPLSAGVHYVNYIATDADGLSANCNFRVVVKAAPVEVLEPRRPLSPSGGPPRPAEMTRLENHESYLICPGKPPVRLDASHYPVSSRLHIVLHTIWHGLQPGTGPDVHATQLPTPHSSAHAARKLPDSGADRHSPQALYSHPHNHHRYRHEHAHQHNRNHSQGQAEAVLNQTAPILPMMGRGNHSFAGVLRVTLGNGTSTNVTGIANETRDASGVLALQRTYRPTLGSRGLTSTATTHKHVGGNFTHRTLRTDHHQHHQLHHHHLLRAHNLNLGQALKEPSATVHRSRIIHIIEHRSSEGCCEEEGNCDDESTRSRATSGREPAAGRMTEGVNVEYFIDIFQWVGQQRRGLEERSRRAQLPYNSRQYPTRHPHQHRVTGRQGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAI3</accession>
    <name>A0A084WAI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015252</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015252-RA">
        <property type="protein sequence ID" value="ASIC015252-PA"/>
        <property type="gene ID" value="ASIC015252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015252"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14728" checksum="A2A3001966636E8F" modified="2014-10-29" version="1">MKNQRKRHLLMRKEATTTAAPIFVREYLPFRCNQRWSILHAGLLRMSVIFPNGTALRQIANQMPNHSKLCNRSVTGGEKNVLSSRKGNIGLQTIQHVGAERVADVICHNVSRSPAGQPIDQSDFLKQKNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB46</accession>
    <name>A0A084WB46_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00015386</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01022312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB46"/>
    <dbReference type="STRING" id="74873.A0A084WB46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015386-RA">
        <property type="protein sequence ID" value="ASIC015386-PA"/>
        <property type="gene ID" value="ASIC015386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015386"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022336"/>
    <dbReference type="OMA" id="DTHCVPV"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000064">
        <property type="entry name" value="BR serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="703"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="866" mass="95681" checksum="9A5803D02DB3870B" modified="2014-10-29" version="1">MSREVQKENATPATGTTEGHQYVGPYRLERTLGKGQTGLVKLGVHCVLGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLGLTDVYENRKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDDKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRRADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLKGMIEVNPEKRLTLAEINKHPWVTAGGKGELELELPMMEVVQTHVIPNATAVDTDVLNAICSLGCFKEKDKLIQELLSPHHNTEKVIYFLLLDRKRRRPAIEDEEDVLRPRNDIIEIADPPRKRLDTCRINGSSSLSYGQISEGSPLTSRRQTFNNGHRSHSGSTSSSSRRSPSSVPLSRSSYQSPTRGVVVNSSQPLNQLHPPSSPNAASNRHSNYSPRSSTKSQVIDSSSPVHHRANSGPAVTVGLFSETDSNNMTSSINAIPGSPILGSPQQLQAVTTGSQLWKTRLTNIKNSFLGSPKFHRRKMQISTEEVHLTPESSPELTKKSWFGNLMTTEKDETFTVLVKGKPLATVKAHLIHAFLSMTELSHSVLSPMSFRVEYKRGGTGPTMFQRHVRIQVDINTICKQGDVGDMLFAITFTLISGNIRRFRRICEHIQAQVCSKRYPALSSPTNQHNNKVTNSVAESISCGSDSSDRINYNKHKESDIEQETFYDTTSIGKTRRSSATSSNKNSVSSDEIEIKTVRSSSESTERERERSTERPAAMSGSALDSVNSGTPTETVATGPNPTHAGESIVAPDVPGDANVAAATAEDVDVSGELMELIANQMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBG7</accession>
    <name>A0A084WBG7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00015525</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBG7"/>
    <dbReference type="STRING" id="74873.A0A084WBG7"/>
    <dbReference type="MEROPS" id="C14.040"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015525-RA">
        <property type="protein sequence ID" value="ASIC015525-PA"/>
        <property type="gene ID" value="ASIC015525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015525"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001511"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011994"/>
    <dbReference type="OMA" id="QHAVQRI"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056260">
        <property type="entry name" value="Dredd_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056259">
        <property type="entry name" value="Dredd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23724">
        <property type="entry name" value="Dredd_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23725">
        <property type="entry name" value="Dredd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="12">
        <location>
            <begin position="257"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="11">
        <location>
            <begin position="417"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="758"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="806" mass="89355" checksum="085D33FFC1A0971F" modified="2014-10-29" version="1">MTVQLSQEDVTFIENELSFVDKVSLIFLLYGQRNPQYALQILNVSGRMLSEETSFLVDWTNYKRSTSWEDELLEALTILEQNLLLLRAGFDDDELRSKYFPQTAEIALHVHPILKGLYQFCERLDDKTSMQLMKQLKQYVGNASVPQDCLEIVLLHLISNDTINLGSRASGKECDLVALTAACKSVELYDESEFLKGISQHYNNAVKAEQQVQSDASSKSYQSAVQQPIDVVEALNKKVVTITKTPTLECYDFDPQRAGIMLLVNQFRFYRETNPELVDMVPSKALKDRKGTEVDKNALVQLFTDLGYEMILEENITHHQIVQAVQHAVQRIRPAHCSLVVCLLSHGQEGIVYGSNSVPVEVKAIQHLMASERLTGKPKILIVQACQGSDLQSAVPVPTYEHDGLDSDDRTASVFMDFLVAWSTVPGFASIRHVEKGSWFIQELCTKLRQLYKSEQIMDILTSVINDVSSKRGYGNECMNAMENPLCTSTTATNSTVSVLLWTTIAVFGIVYTLLGYRCLRAIGFLTGLAAGAGCIVLLQNKNITSFGNLAAPALAVVAGLFGAVLGSTHPISSTLIGTAAGALVAGATIAACIATLPHYTFGENELLVSVVGGAIICAIVTLFCPKFMSIVASSIIGSAMILCSIDFFMHGLNTMDWIFNMKPDPTPPPCWGGVILCCWPIASVLGVLVQCFVTAWKIDHRRQLHHRRRRHYKGRSGSRSRETREEARQRKYRYLYQVRTARGDIISQNFVSALQKHVTTDSGPPSEVSTKTGSNDRNTARSDRTHLTNLADSDFDKMDSSCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBS6</accession>
    <name>A0A084WBS6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015715</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022437">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015715-RA">
        <property type="protein sequence ID" value="ASIC015715-PA"/>
        <property type="gene ID" value="ASIC015715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015715"/>
    <dbReference type="OrthoDB" id="5912242at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11411" checksum="0ACDB98504A8FD8E" modified="2014-10-29" version="1">MAARVDCLCPGPRCHNQSPLTVGRRCLYDSHCITNAYCKGQMICTCKREYGFLADDNWSCQASSGKASPRIGTSRIGGFYELRRLLPLLVATGLLLTICKRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCG4</accession>
    <name>A0A084WCG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015966</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022667">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015966-RA">
        <property type="protein sequence ID" value="ASIC015966-PA"/>
        <property type="gene ID" value="ASIC015966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015966"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010340"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="16689" checksum="81304351CB006348" modified="2014-10-29" version="1">MQLRQIWLTVPPTPRTSWLQMGFNASLDRRTSITTTFFTLPTVGNRGSSSSRWTVLVPSRTESHAVDERPIRDHRSSHTDPHILSIKQIHVRIPKSVKRANVMNGGNNAMPRIGRDSEVRKENKEHRSRQACDYRRNRADREFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCM4</accession>
    <name>A0A084WCM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016096</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016096-RA">
        <property type="protein sequence ID" value="ASIC016096-PA"/>
        <property type="gene ID" value="ASIC016096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016096"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000183"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="205" mass="21663" checksum="52BC3E636942B4DF" modified="2014-10-29" version="1">MQLILVMIVPVQSFFRQIMATSLPLCLLSNASLVILSGAGVLKNVSVMRRTLIQAVALVLTLGLPSGHASHYSHLHHAHENHIQQVSCIKTFTQPIVTTTVPATTSFTSITNTVSTYTIVTPPPVLLLETSTSAISTTVGTITPSTVITGTTTSTFTSTPPLVPAVTTVTTTVVTRPTTTFTVTLSVTSTSSIITTRTSRIPMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCM8</accession>
    <name>A0A084WCM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016140</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016140-RA">
        <property type="protein sequence ID" value="ASIC016140-PA"/>
        <property type="gene ID" value="ASIC016140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016140"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="22302" checksum="B1565D54BE2DE7F1" modified="2014-10-29" version="1">MELFTFVYAIDASDRSELAERTERFPRYPVSLEKGSGKCVKVVKIVKRSMGLFPDPPITPKLKKRLFGGGGSQRKSAAAAGGEAGAGGDASASARGGGDGGSVAGGSGGKGRGGKNEDRSGASGSLSKSSTPQQLSTSWEFIRQSGAARLCRQPFSLPVGIRQPHKEMTISHGFTCEVYVSPGAELFPPLRRPVPNGPPASLRASPLLEGTTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD17</accession>
    <name>A0A084WD17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Trim46 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016087</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016087-RA">
        <property type="protein sequence ID" value="ASIC016087-PA"/>
        <property type="gene ID" value="ASIC016087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016087"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="195" mass="21684" checksum="3C4E559457DEB602" modified="2014-10-29" version="1">MLRLGFIRTERSRLADPRQLERFNSLPVMAVQTSAPRGRGGVGVGDLRRRPERTSARGSIESYCGEAGEIASEKNPSPVQSPGECTCNFSLQLHKHGNILPTTSAVFFSSSVSFSATIPSRTKAPGFYSTIPELLARAGTYWRKFTPWASARFREKKRWLSRALKLLIRKTQQHPPKTLDGCPPTPSRRSSGWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDB5</accession>
    <name>A0A084WDB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016327-RA">
        <property type="protein sequence ID" value="ASIC016327-PA"/>
        <property type="gene ID" value="ASIC016327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016327"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5518" checksum="5BDA16F6EECB6C1B" modified="2014-10-29" version="1">METKATRWQGATGSGDRHHRFSGDVPPQRITGGGTGNAGGAVINVLAVVAVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDK2</accession>
    <name>A0A084WDK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Monocarboxylate transporter 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016273</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023039">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016273-RA">
        <property type="protein sequence ID" value="ASIC016273-PA"/>
        <property type="gene ID" value="ASIC016273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016273"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10586" checksum="530045C26CD1D86F" modified="2014-10-29" version="1">MGHFSRPAAGMLIDAVEDAYRYGITLEVKFSSYASQRQYGGNFGNVWRHKNSNPGKVFPLALWVGVEGCGKMEIVLQFWEINTTVGVQMLVTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE13</accession>
    <name>A0A084WE13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP004954-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016441</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE13"/>
    <dbReference type="STRING" id="74873.A0A084WE13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016441-RA">
        <property type="protein sequence ID" value="ASIC016441-PA"/>
        <property type="gene ID" value="ASIC016441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016441"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001578"/>
    <dbReference type="OMA" id="WWRQLIA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="265" mass="31283" checksum="864FB71A2B46D53F" modified="2014-10-29" version="1">MSLSRFRLITFDVHNTLLQFRSSPGKKYGEIGAMFGISNNNNQLVSNYIQSWHKMNRLHPNFGLKTKITYKQWWQMMIDGIFNENGTHNTPPEKIEQMTEHFMEYFKTSVFWQHCYGSVDFLNYLKLQRHVESNGQKEPPFKLGVISNFDPRLDVLLRNMKINHYFDFVLNSYDVGYMKPSKEIFDRAMQSAEIKDLKPHECLHIGATPATDYFGARNAGWYSLLVHEKSAEELTRKYGQLVEDNHVFSSLFDIHKKISNDYMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WER8</accession>
    <name>A0A084WER8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00016714</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01023246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WER8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016714-RA">
        <property type="protein sequence ID" value="ASIC016714-PA"/>
        <property type="gene ID" value="ASIC016714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016714"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018506"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="635"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="816"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1281" mass="146396" checksum="0EC6EE1B3DAE207F" modified="2014-10-29" version="1">MDELEQLEHLSLVSKICTELENHLGLNDKDLAEFIIDLAYKNPALDAFKRVLAENGAEFSDSFTTNLLRIIQLMKPASGKRGTGSAFEDDANDGNNLAYKFPGLAIPNNKKGYSSDEGEYEGKEDQKDRKEDKKTTNKVVVDDMFSELEKMAPSKAEKKIDSKSREQLEVDNMFAELESLAPSKSAEDGGGKEAKRKDRRSHSRERRKERSKSREKRRDRSKSRDRRRRSRSKDRKRRSRTRSRERHRDRERDRSGRDRDRDRERDRDRDRDRDRKSRRSRSRSRSKDRARQRNRSPSVDRMMVEKRKRTPPMPEEPEPGKIYDGRVVNIVAFGCFVQLVGFRRKKEGLVHISQLSTEGRVNLVTDVVNRGDDVKVKVMSLAGNKISLSMKEVEQSTGRDLNPLSHSHLKDAAESDLPGRNPDRPMSMIPSMLNLQEGTLEPVEETSRKKVTRISSPERWEIKQMISSGVIDRSEMPDFDEETGLLPKDEDSEADIEIEIVEDEPPFLQGHGRALHDLSPVRIVKNPDGSLAQAAMMQTALAKERREHKMLQREQEMDAVPTNMNKNWIDPLPDEDDERTTAANTRGVGMSTQDVPEWKKAIIGGKKSSFGRKTDMSLIEQRQSLPIYKLRDDLIKAVTDNQILIVIGETGSGKTTQITQYLAESGFIARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRFEDCTSQETVIKYMTDGMLLRECLVDFDLKSYSVIMLDEAHERTIHTDVMFGLLKQAVQKRPELKLIVTSATLDAVKFSQYFFEAPIFTIPGRTFPVEILYTKEPETDYLDASLITVMQIHLREPPGDVLLFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKAYRLYTERAYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHFDFMDAPPVESLVMALEQLHSLSALDNEGLLTRLGRRMAEFPLEPNLSKLLIMSVALQCSDEVLTIVSMLSVQNVFYRPKDKQALADQKKAKFNQIEGDHLTLLAVYNSWKNNKFSNAWCYENFVQIRTLKRAQDVRKQLLGIMDRHKLDVVSAGKNTVRVQKAICSGFFRNAAKKDPQEGYRTLVDSQVVYIHPSSALFNRQPEWVVYHELVQTTKEYMREVTTIDPKWLVEFAPAFFRFSDPTKLSKFKKNQRLEPLYNKYEEPNAWRISRTRRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF06</accession>
    <name>A0A084WF06_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dyak\GE21606-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016812</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016812-RA">
        <property type="protein sequence ID" value="ASIC016812-PA"/>
        <property type="gene ID" value="ASIC016812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016812"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020319"/>
    <dbReference type="OMA" id="IWSLTPM"/>
    <dbReference type="OrthoDB" id="6593925at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11951" checksum="0956C9BCDD5B82C9" modified="2014-10-29" version="1">MGGIDASRWKPRRTKGTVIYKTRNQFAWAVIAAGTVFFATFYSVVSYIGGDDLKQRLRRDFFEKTEEEVDRKNLMRFSLIAPKRGDTIRKLLEEEKEDQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF66</accession>
    <name>A0A084WF66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017120</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017120-RA">
        <property type="protein sequence ID" value="ASIC017120-PA"/>
        <property type="gene ID" value="ASIC017120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017120"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="163" mass="18314" checksum="21173F8C1FF0E356" modified="2014-10-29" version="1">MEHEAGQRQVVVIRKTCPPSVGVVVVRDMLRPGAWCRPFLGPSPADDNQNIRFLGWAKDSNINRRSNTNSTVYHQRKQSVGENRFSRSGVPDSRYGPIGRCAQPWNLPSATNNNGQRAVAAPGRKESPRGSAAHIRSVPKMAMSSWMIRRSIRQRSKNHCIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFD1</accession>
    <name>A0A084WFD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000847-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFD1"/>
    <dbReference type="STRING" id="74873.A0A084WFD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016921-RA">
        <property type="protein sequence ID" value="ASIC016921-PA"/>
        <property type="gene ID" value="ASIC016921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016921"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002568"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="228" mass="23336" checksum="6B8B94EA7EF1D0DF" modified="2014-10-29" version="1">MPILSPPSLPPTHTKQQQYGEAKKFTNGRAAGGKKEHRENHHPDSNGTTISSYPSAPTVVGGASTNGRKHTAPSPPAAAAPVASTGRPGALLRDRNKRSKSPPRSSGSGNSPSDQNGAGDGAAPVVAAPPPVANGTSTPSTPTTTAPTATPVPSTIRGSGPNGELTLKDIPVSGISFQEIFKADHEGPPTTQVIIYKPKSGKGQPTAKVIVTKRAHPKYLVSYLKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG46</accession>
    <name>A0A084WG46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009812-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023441">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG46"/>
    <dbReference type="STRING" id="74873.A0A084WG46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017190-RA">
        <property type="protein sequence ID" value="ASIC017190-PA"/>
        <property type="gene ID" value="ASIC017190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017190"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005044"/>
    <dbReference type="OMA" id="YHYQPVA"/>
    <dbReference type="OrthoDB" id="6347385at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="365" mass="40844" checksum="53AC6C674F3385F9" modified="2014-10-29" version="1">MQPPQRYIPSVSDLYGTDEIEFLLDEIRDLEPACCQLEDIQDFEIAGSRAGELSISLESPIGTCTSWDSHAHYRQRIGNTPLPWGVALHCDASHLTSPTGIVRILLVVSSAACLACECSAGTVQVGLFLLPLIGRLRLMVFCALFSLLVTCLMLFLDISHIALMFPFNWGRLNAWLYLTIGLLFIVGSSLLIHMVFFAEEFMWVPKHSKDTLFISAILGYICSIEAFALAALTKCPSQYRHVIDEYSDMCLEERELSPICSNDLTNHNHTTASNELSNHRSYNRIDTGDSITPTCNQKPYIPVKRPDQSYNQRPTLGNMQKSNHRNRQGYHYQPIASTSRQSPTFVLDEDALPGPSSRSLDYSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGA9</accession>
    <name>A0A084WGA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Multidrug resistance protein CDR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017362</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017362-RA">
        <property type="protein sequence ID" value="ASIC017362-PA"/>
        <property type="gene ID" value="ASIC017362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017362"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16391" checksum="39166103D4E592C3" modified="2014-10-29" version="1">MPRVGSRDFKSAPAGVSGWCWSIAPKRLISSADAAVDARRDVEGVCEYGQSTVRHGFTSTEPLMLATNTSAFRRLTRSQLTHAGNGSDDAMTRESGHTVKGGQSDAGLVHATRSFDLEFGEVHRTPQGSHLPNATFERHTRSCWWYRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH53</accession>
    <name>A0A084WH53_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017755</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017755-RA">
        <property type="protein sequence ID" value="ASIC017755-PA"/>
        <property type="gene ID" value="ASIC017755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017755"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12467" checksum="B928096CDB3DBC01" modified="2014-10-29" version="1">MASDPHERSVTTEQFPEIAMCRRATSRFPVKPLENWHRRFEKEKPSNPNAWALEMVSGAGVFPSPISITARTGPGRVVRNWFIAGLIGAKIHSFNVGRKPRLPPMRRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHH3</accession>
    <name>A0A084WHH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017826</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017826-RA">
        <property type="protein sequence ID" value="ASIC017826-PA"/>
        <property type="gene ID" value="ASIC017826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017826"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="11773" checksum="EA731DFE69DDDFFA" modified="2014-10-29" version="1">MCGPRMEPTSTESAVAPRLHLSNGASHSSHGVAAFSVAVHCTSLHFIAIVVVVGDDDDDDDGNDEESAATIASECNAEFEQLWRAGALQLSHDCHRAIVAMLCSRCPGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI36</accession>
    <name>A0A084WI36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NusG antitermination factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017907</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017907-RA">
        <property type="protein sequence ID" value="ASIC017907-PA"/>
        <property type="gene ID" value="ASIC017907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017907"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8697" checksum="0AB3A4771AE06719" modified="2014-10-29" version="1">MIALVRLSVCNEAARWATIDTKPTKHRRAVEECRYSNYGVRFEQAQGVLPGAALERQQCNAPRARLSHRLKSENASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIE3</accession>
    <name>A0A084WIE3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018027</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIE3"/>
    <dbReference type="STRING" id="74873.A0A084WIE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018027-RA">
        <property type="protein sequence ID" value="ASIC018027-PA"/>
        <property type="gene ID" value="ASIC018027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018027"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011685"/>
    <dbReference type="OMA" id="KDVEILW"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="27188" checksum="C19079D33657DEEB" modified="2014-10-29" version="1">MAEEAVKSLSETIQHADQLFDENNFQEAYDLLQKYPEQETYDIKWRLARVTYSLSKPVPSPRKEELVREAFRYAEEALKLNDSDFASHKWYSILLDAKSGLDGIKERVTQLETVKKHMLRAVELNPNDPTSWYILGQFYYGLADLPWYQRKIVSTIFATPPTGTYEEALECFEKAESTKPNFYSMNHLMMAKTYQALKQTEKAKEFMTLAANVAVLNEDDKQCKEEATKLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ48</accession>
    <name>A0A084WJ48_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00018317</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ48"/>
    <dbReference type="STRING" id="74873.A0A084WJ48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018317-RA">
        <property type="protein sequence ID" value="ASIC018317-PA"/>
        <property type="gene ID" value="ASIC018317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018317"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007275"/>
    <dbReference type="OMA" id="CVIFTAM"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000144">
        <property type="entry name" value="AGAP011765-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000046">
        <property type="entry name" value="AGAP011765-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4060:FF:000004">
        <property type="entry name" value="Fat-spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000150">
        <property type="entry name" value="GM21753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000026">
        <property type="entry name" value="Spondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF23">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784941" description="Spondin-1" evidence="13">
        <location>
            <begin position="30"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="15"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="16">
        <location>
            <begin position="188"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="654"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="794" mass="88673" checksum="C926DC9EBC235173" modified="2014-10-29" version="1">MEPPSKRPRRWSAGAIILLVVLFVGLSEACSKVPVLDGRPVATPKQPGDNGYRLAIRDDPKGYEPGKIYNLFIVGSRTHAKLQQFSHFTLVAHAKNGARSFIAGPKRVGRFQLFSDSLTKFHDQCVNTVTQADDFPKSEIQVMWVAPATGSGCVAISAMVFEDEQHWYADEGSLTRVLCEHKPEPRIQKGECCACDEAKYSFVFEGIWSNETHPKDYPFAVWLTHFSDVIGASHETNFSFWGENHIATDGFRMLAEWGSVRLLEQELRAKGSRLRTLIKAAGLWYPRVNANTTSNFRVDRKHHKISLASMFGPSPDWVVGVSGLDLCRGDCTWTESLDIDLYPWDAGTDSGISYMSANAETQPRERMHRITTLYPEDPRAPFYNPRSKEMTPLARLYIRRERLVARNCDEEFLQAQVLELAENTEEETRAECATTDYSEWTPCSVTCGKGIRMRTREYLQPEKAATFQCNRQLIAKEMCVADVPECGTDGGAAAAEGDDATGEMSSEDVGQSVANVDDDGEGVGVCRTTKWSEWSECSVSCGIGVSMRTRTFIEHMGRKKCPHISIVEKQKCMQPECSITEMEAPDPLCPVTSWSDWSPCSATCGKGVTIRSRLLLLSPADQEYCRNRIELNQQRPCTDKADCLYDTFTAQEICSQLPEAGPCRGRYQRYAYDANQGTCVPFFYGGCRGNRNNFLTADDCVQTCKATLSARPETHTTEDEDGEHRTEGPRTNPYDTLPVDCVLSDWSDWSPCSVTCGTGRSERVRTIVTQPRNGGQPCPPRVVKRRKCTGPPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ68</accession>
    <name>A0A084WJ68_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ68"/>
    <dbReference type="STRING" id="74873.A0A084WJ68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018340-RA">
        <property type="protein sequence ID" value="ASIC018340-PA"/>
        <property type="gene ID" value="ASIC018340"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018340"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016290"/>
    <dbReference type="OMA" id="TLWINEY"/>
    <dbReference type="OrthoDB" id="6478865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018340-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41326" checksum="CE42F3E6FDF1430D" modified="2014-10-29" version="1">MLLDREPDTLEALRGLDPAEHLVLDCEYVIEPHEQGFVLKWLHNDVPVYQWIPPHRSPSSLQTRMRDHVNRTYTVNGEPMHKHRALALMHPCQELAGKYTCYVQTYTSIDRQSADLFIIVPESSMVLKYHRNPSDLVTVVCSAYGSFPAPELSLWVNDYKQNATSNEFPAADGLFDSSVSVQLVLYETLEPDDVIKCTLEVPGTDYRRTKETVFVAADSRPFGDSNSILDPFGTVPASSTSISRDALPSSAAQLIPSSSTEGKTTTSTSEVHMMTPSEGTSSTKATTVGLAPAPTAKEQSLRPQIPSLTRLRPTASPARVLTVQQSNSVDPDETMNVLDFKEILNENLLYNSAGVRLADFMHQFRRDFVAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK22</accession>
    <name>A0A084WK22_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018881</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK22"/>
    <dbReference type="STRING" id="74873.A0A084WK22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018881-RA">
        <property type="protein sequence ID" value="ASIC018881-PA"/>
        <property type="gene ID" value="ASIC018881"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018881"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018881-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9993" checksum="7CAFF5780E113CD4" modified="2014-10-29" version="1">MKMSKLSNQTNSQDPQAVNSRVFVGNLNTFQCSKTDVERMFQRYGRLAATMRYDGEINRSKFPSSALGSNQNPNSHPNGRVRRLERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK61</accession>
    <name>A0A084WK61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP005641-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018925</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK61"/>
    <dbReference type="STRING" id="74873.A0A084WK61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018925-RA">
        <property type="protein sequence ID" value="ASIC018925-PA"/>
        <property type="gene ID" value="ASIC018925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018925"/>
    <dbReference type="OMA" id="RWETSIG"/>
    <dbReference type="OrthoDB" id="448492at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000086">
        <property type="entry name" value="Cold shock domain-containing protein C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10276" checksum="5D7A2F95E4686ABD" modified="2014-10-29" version="1">MRNPIEEGKVKSFSRSKGHGFITPNAGGDDIFVHISDIEGEYVPLPGDEVSYRLCSIPPKYEKVQAIHVQITHLTPEKHSRWETSIGHELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK94</accession>
    <name>A0A084WK94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018670</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018670-RA">
        <property type="protein sequence ID" value="ASIC018670-PA"/>
        <property type="gene ID" value="ASIC018670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018670"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018670-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9654" checksum="062F49F8D9A3573F" modified="2014-10-29" version="1">MKLKHDFILWHKVCDGSAYETLANLVDAISQLELIDITVESSVLCSSEALHWCHPVTEGRETGVVLLGNLTTSKRNVAAGEHGHGSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKI8</accession>
    <name>A0A084WKI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018777</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018777-RA">
        <property type="protein sequence ID" value="ASIC018777-PA"/>
        <property type="gene ID" value="ASIC018777"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018777"/>
    <dbReference type="OrthoDB" id="7459081at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018777-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6660" checksum="7191E6EC4F343052" modified="2014-10-29" version="1">MCVGSRRGSGESYYQELAETNVSNQRGPGGRGNRELRGCFHEQPGASISPAKNWKIVFSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMK7</accession>
    <name>A0A084WMK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP006521-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMK7"/>
    <dbReference type="STRING" id="74873.A0A084WMK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019502-RA">
        <property type="protein sequence ID" value="ASIC019502-PA"/>
        <property type="gene ID" value="ASIC019502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019502"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008780"/>
    <dbReference type="OMA" id="NCFGESD"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000010">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-13 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001723">
        <property type="entry name" value="Guanine nucleotide-binding protein G(f) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF367">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(F) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019502-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="384" mass="44874" checksum="996B0AE30E8CF0D7" modified="2014-10-29" version="1">MLLIDCFRRPSHELQARKKQSSKEMVQMRKSIRDPVKILLLGAGESGKTTIIKQMKILHIQNSYSFDERLEKLADIYENIHESIYELVRQVVLLDLEFDSVTNQRCAEYILRMGSQAPWNLSTEYVQCVRRLWSDTGVKRCYKRSNEFHLIDSVKYFLDRVEKISMPGYIPTNSDILNCRKTTTGIQETRFNVRMANSLGGGVQEFRMFDVGGQRHHRSKWMQAFEGVHAVLFLISCAGFDQTLREDPKQNRLSEGFELFRGVWHNRFLAETGVIVFLNKQDLLEQKLLAGKSIRTYFPEYDDYVAFADKDQLYDELARTRSFIRSKMVDITNEPPRRTSHLIGRKRTCFFHYTVATDTQNVRTVFSDVHNIILTRNLSKVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMP3</accession>
    <name>A0A084WMP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006552-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019544</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019544-RA">
        <property type="protein sequence ID" value="ASIC019544-PA"/>
        <property type="gene ID" value="ASIC019544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019544"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784943" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10740" checksum="10E62A7D4E84E91B" modified="2014-10-29" version="1">MKSIVAFAMFIGCVAMVQSGCVRTYPSYDYSGVLSYPEARPFCGLRNDVYPHGAPYVGPVYPYGRVPCGGCGSCSSCRGVHVPKCGGCGSCSHCRNAHVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMU6</accession>
    <name>A0A084WMU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006813-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019604</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMU6"/>
    <dbReference type="STRING" id="74873.A0A084WMU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019604-RA">
        <property type="protein sequence ID" value="ASIC019604-PA"/>
        <property type="gene ID" value="ASIC019604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019604"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018020"/>
    <dbReference type="OMA" id="ECTDPRE"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785234" evidence="3">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="11934" checksum="50BD49B33DF280FA" modified="2014-10-29" version="1">MVRKIAALLLLIASLGVVLVESNNATAQHTVTTTTEEPSEDVVEEMPIISCTGVAEVYNVCGPACGDRTCDNQGRSDVPCTKQCVEGCYCRSGYVRNKAGTCILPYRCGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPQ6</accession>
    <name>A0A084WPQ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">ZHAS_00020307</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="30 32" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01025119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPQ6"/>
    <dbReference type="STRING" id="74873.A0A084WPQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020307-RA">
        <property type="protein sequence ID" value="ASIC020307-PA"/>
        <property type="gene ID" value="ASIC020307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020307"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024442"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="20" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="27">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="29">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="28">
        <location>
            <begin position="253"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KFB52200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="728" mass="79382" checksum="82411B4D6D5AE8CC" modified="2014-10-29" version="1">MLRVPVTRALALGARYPMQTIVRTSATTPAKLPEKIEVFVDDQPVMVDPGTTVLQAAAQVGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSEMTRKAREGVMEFLLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDIHHTGKRAVEDKDIGPLIKTIMTRCIHCTRCIRFASEVAGVDDLGTTGRGNDMQIGTYVEKFFLSELSGNVIDLCPVGALTNKPYSFVARPWEIRKIESIDVLDALGSNIVVSTRTGEVLRILPRENDAINEEWLSDKSRFACDGLKRQRLIAPMLRNPSGDLEAVEWESALITIAQALRGAPKGKVAAVAGGLADAEALVALKDLLNRLGSETLCTEQKFPTDGSGTDFRSSYLLNSSIAACEEADLVLLVGTNPRYEAPLLNTRLRKGYIHNEQNIALIGPKVDLSYDYEHLGSDTSLIRDIANGNHPFAKKLKEAKKPLIIVGANQLARKDGSSFLTALHVFANSLSPADKNWKVWNVLQTNAAQTAALDVGYTPGMDAVYELQPKVLFLLGADGGVVDKEKLPKDCFIVYQGHHGDVGAQQAHAILPGAAYTEKQGTYVNTEGRAQQTLVAVTPPGLAREDWKILRALSEVAGTPLPYDNLDELRARLEDVAPHLVRYGRLEAANFFSIADALLKNASVSFDGSKVDVGQKKLSDFFMTDPITRASPTMAKCVTAAKKQATQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ12</accession>
    <name>A0A084WQ12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Hisitdine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020504</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525370">
        <property type="protein sequence ID" value="KFB52306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020504-RA">
        <property type="protein sequence ID" value="ASIC020504-PA"/>
        <property type="gene ID" value="ASIC020504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020504"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9841" checksum="B6041DC1899F49C0" modified="2014-10-29" version="1">MHGSTTTRWRLLLDSAPQFRSVAKKLTPRGQEENTTDANREAHAIRCGQNLTRPDKQLIRKCATRSRSSVLYSSRKRSRSSAGPMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR40</accession>
    <name>A0A084WR40_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00020940</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01025918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR40"/>
    <dbReference type="STRING" id="74873.A0A084WR40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020940-RA">
        <property type="protein sequence ID" value="ASIC020940-PA"/>
        <property type="gene ID" value="ASIC020940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004438"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="374" mass="42248" checksum="A4AC17182501D5A9" modified="2014-10-29" version="1">MSEMGKHLCGTDNCKKSATLQCPVCLKLGIQGSFFCSQECFKGSWKEHKFIHLLAKDKDSKAYNPWPYYTFTGKLRPFEQSPMRTVPLAIPRPDYADHKEGRSKSEEALRGNNTIKVLDDEEIEGMRVACRLGREVLDEAARVCGVGVTTDEIDRVVHEAAIERECYPSPLNYYNFPKSCCTSVNEVICHGIPDMRPLEDGDLCNVDVTVYHRGFHGDLNETFFVGNVQEQHKKLVQVTYEALMKAIAIVKPGERYREIGNVIQKHVQAHGYSVVKSYCGHGIHRLFHTAPNVPHYAKNSAVGVMKPGHCFTIEPMISEGTWRDVSWPDDWTAVTADGKYSAQFEQTLLVTETGCDILTKRRNETGTPHFMDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR50</accession>
    <name>A0A084WR50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP003691-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020951</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR50"/>
    <dbReference type="STRING" id="74873.A0A084WR50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020951-RA">
        <property type="protein sequence ID" value="ASIC020951-PA"/>
        <property type="gene ID" value="ASIC020951"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020951"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012721"/>
    <dbReference type="OrthoDB" id="7755702at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020951-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13367" checksum="B1087B446EE54DB0" modified="2014-10-29" version="1">MHPFVFTFGSDDEGLALPVSKYIEWLGTVTEEKIKSSDCVSQYIEYREYEDSMVQRSDDYQSAQYSKSRLSSTSVSQYKVRIVPNTTETGSKRHCYGSLVAPQFILTAANCLHRYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRR6</accession>
    <name>A0A084WRR6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021190</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021190-RA">
        <property type="protein sequence ID" value="ASIC021190-PA"/>
        <property type="gene ID" value="ASIC021190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021190"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18145" checksum="2425AFD94C089F2A" modified="2014-10-29" version="1">MTTNGCNLEQKPPPKLDRLPMFPISRTISRARSLKAPTVQFNSCCNGKGNFDSFLLPPPQRKVFVTSPPVREKHPPGPGHINPSWKALGVVHIGTEAIGIRFCSTEGSLLQEHRMVLHLGIYPTHGRRRMAQHGRAHDKSARTRRRSRNGNFKPEPTGRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRX4</accession>
    <name>A0A084WRX4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP005239-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021257</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRX4"/>
    <dbReference type="STRING" id="74873.A0A084WRX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021257-RA">
        <property type="protein sequence ID" value="ASIC021257-PA"/>
        <property type="gene ID" value="ASIC021257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021257"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006234"/>
    <dbReference type="OMA" id="GWVHNKK"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="207"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB52968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="308" mass="33465" checksum="1F771AA8A153322C" modified="2014-10-29" version="1">MDGTDFLLGGLGSMGATLITNPLEVVKTRMQLQGELAAKGTYHKPYRGVVDAFVTIAKNDGYMALQKGLAPSLCFQFILNSCRLGIYNTANEHGWTKQANGNQSVLKSAFWGATGGFVGSALASPFFMLRTHLQSQAKAVIAVGYQHQHTGMMSALKEIFQKHGIQGLYRGVSVTMPRALLGSGGQLAAFGYTKDFLTRRPIMQHQSETFVSTVAGAVGGTVMAITMTPPDVIATRLYNQGIDAKGKGIYYKGVVDCCIKILKTEGVGGLYKGFWPHYMRIGPHATLVLLFFDELKLLRTKYYASKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSI9</accession>
    <name>A0A084WSI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002084-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021487</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026578">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSI9"/>
    <dbReference type="STRING" id="74873.A0A084WSI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021487-RA">
        <property type="protein sequence ID" value="ASIC021487-PA"/>
        <property type="gene ID" value="ASIC021487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021487"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023729"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="304" mass="32533" checksum="530CEA7130309CE8" modified="2014-10-29" version="1">MSSGDRLGGGSGESWVHWNNTAAATLRTTVGKGGSNSLTPSRQRLRGEHVGARASDGFGRQNIESVRQQQYANITKSVAEVEQARAANQSDGSQTTESTDTGGDGSETKVNGSIPNGSSTTGGQHRLSNGGDASYIVNGGNTVISRAESLILSPEMIDDTRSKSTEPHEEDGTSVGEEGTDGEDGAGTDGGSEGGGEHEAAGFKLANCLDYVKSGMEAIIEDEVTSRFLAEELKNWNLLTRTNRHYEFISWRLTVIWMIGFLIRYFILMPMRVLICFIGVSLSVAECCRKCSYGVHPQTKANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTL5</accession>
    <name>A0A084WTL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021792</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021792-RA">
        <property type="protein sequence ID" value="ASIC021792-PA"/>
        <property type="gene ID" value="ASIC021792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021792"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8619" checksum="323C66FEE130BF61" modified="2014-10-29" version="1">MRLLHLRLGEGWDGGTLARIGTGRNRTQPTFAIPLLKAIAFDVVHLQHADILCSLRNGMHMHTEQPARGARGKRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU86</accession>
    <name>A0A084WU86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002950-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022014</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027010">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU86"/>
    <dbReference type="STRING" id="74873.A0A084WU86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022014-RA">
        <property type="protein sequence ID" value="ASIC022014-PA"/>
        <property type="gene ID" value="ASIC022014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022014"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009660"/>
    <dbReference type="OMA" id="ANDCCEL"/>
    <dbReference type="OrthoDB" id="7791141at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="402" mass="45133" checksum="DD79C9295A198E17" modified="2014-10-29" version="1">MEVEAAGNVQVESDAEPSSNCSSEDEEELISKRVSIFKNLSFEEGLRYWALLSSLPHVWLNLLLELIREKTHFALPKDARTLLHTNRIPATITSTAGGRMWYNGVQRSLEQRSSIVIMPSSISLNISIDGIPLHRSSREAFWPILISINELPKEAPLIVAIYSGQKKPQSMEGFLRCFVDEMNVILANGTTIRGQTIAVAVRCIIADAPARAMVKGAASFNARQGCLKCTALGTKNAVTGAVVFESTNASKRSDEDFRLERYPDHHRTRSPLLDLVNFDMIEDVIVSDRLHLIDLGVMRKLLQGWRAVYEHFLLFYCAITLLSSSVHKRNWVQAGQMLIQFVSKFNDVYSEGYVTSNVHNLVHVYDEVAKFGALGSLSAYPFENELQHIKNMLRNGYKGCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WV30</accession>
    <name>A0A084WV30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022385</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL646947">
        <property type="protein sequence ID" value="KFB54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WV30"/>
    <dbReference type="STRING" id="74873.A0A084WV30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022385-RA">
        <property type="protein sequence ID" value="ASIC022385-PA"/>
        <property type="gene ID" value="ASIC022385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022385"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024467"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="21216" checksum="77AB90C9F7AC00C1" modified="2014-10-29" version="1">MDLDETDVYTMSRLARMALKTGYLQIAKLYFEKCLKRNPNHWPSMEGMLKVFCSASNVVEAYGWAAQCHRKDTRNKLYVDVLRAIREKFKAALSYLDTVFTVPVAIDFAEEEKRRPLVLAMATFDELFKPRQTGFETPNLTVMPDSLKELLKIDDLSFESIGNVLVKLNDAMEKLDLVRCITYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA37</accession>
    <name>A0A084VA37_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-pass membrane and coiled-coil domain-containing protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00000335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01001581">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523980">
        <property type="protein sequence ID" value="KFB34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000335-RA">
        <property type="protein sequence ID" value="ASIC000335-PA"/>
        <property type="gene ID" value="ASIC000335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000335"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015235"/>
    <dbReference type="OMA" id="FFIYANT"/>
    <dbReference type="OrthoDB" id="10266771at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027960">
        <property type="entry name" value="DUF4519"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="7250" checksum="B12450B370A8AA81" modified="2014-10-29" version="1">MRKLRGGQTKETRKQRQERREENLKIQQQLKTIVLPTVGVLFLCIVVYVYLKTRARYEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAY9</accession>
    <name>A0A084VAY9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP-ribosylation factor 1 GTPase-activating protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">ARF1-directed GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00001054</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01004759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524238">
        <property type="protein sequence ID" value="KFB35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAY9"/>
    <dbReference type="STRING" id="74873.A0A084VAY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001054-RA">
        <property type="protein sequence ID" value="ASIC001054-PA"/>
        <property type="gene ID" value="ASIC001054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001054"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002338"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022016"/>
    <dbReference type="OMA" id="AWDLLMN"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000008">
        <property type="entry name" value="ADP-ribosylation factor GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="20">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="308"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001054-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="506" mass="53850" checksum="1251DA797B4E536F" modified="2014-10-29" version="1">MASPRTRRVLSELKPSDGNNKCFECGTHNPQWVSVTYGIWICLECSGKHRGLGVHLSFVRSVSMDKWKDIELEKMKVGGNRKARDFFDTQDDWDDTAPIQRKYNTRAAALYRDKINTLAQGQPWDAASAAARVKAAGHAGGGSSSSSSGHSSASSAGSHSRGGGSTGGYQNGGDSYYQDGGSYQQYQTPEFKAQKEDFFSRKQEENASRPENLPPNQGGKYAGFGYTMDPPPRSQSHELFDTVQSSLATGWNVFSKVANVAKENALKYGSMASQKVVEVSSTVSEKVKEGTLLEGVGSQVSSLATKVTEVSRKGWGGIGAPGGSYSTPSGSNDQYSNISSDSGVSSPINGRQQQHRGSSGSNRNGGDSWSNGGSGGGGWQNDSNSNSLPQSYQNADNGDDDGWTGFESYSGPTQGSSTKPTYGASSADPASVDLRNDNFERQAKSGGSRRTSNNGATGSRQQSVKSQSSVEQDFAALDIKNNRAPKAGGKKANNNAEDDLWNMLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDB0</accession>
    <name>A0A084VDB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002980-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011205">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524652">
        <property type="protein sequence ID" value="KFB35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002919-RA">
        <property type="protein sequence ID" value="ASIC002919-PA"/>
        <property type="gene ID" value="ASIC002919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002919"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001137"/>
    <dbReference type="OMA" id="NCELIYD"/>
    <dbReference type="OrthoDB" id="8186940at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF4">
        <property type="entry name" value="AGAP002980-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783565" evidence="1">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="28112" checksum="8525A5371D76C9DE" modified="2014-10-29" version="1">MRPAVVVLLGVWLVLVSIALVQGTTSRHDGALVTLSRTKRKALLFPIQTTLQVSMCTATDGRLFFPKKKYSARKLGINLGFQQNFNLPFRLLEFYKPPTWARAIAGIVRGYFPSTSVVTARNWKRSTDHEHNFQPLALSAGQLYTLTEDFLQVFGYDKDCLLRSVCELAHSPFDRAELEQDFMAEVVHLLLSPSVHESFADDEQELKRAYEMAERLGASGANCELIYDRCYRSVLSDFSNLIDDHSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDM6</accession>
    <name>A0A084VDM6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00003100</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VDM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003100-RA">
        <property type="protein sequence ID" value="ASIC003100-PA"/>
        <property type="gene ID" value="ASIC003100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003100"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003047"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009650"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="421"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="688"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="792"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1133"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1293"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1316"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003100-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1719" mass="192616" checksum="E42A375840824878" modified="2014-10-29" version="1">MRPKSRTRAGAIAATKPPAPSGRIAAQEKSLCQDFRALDVLMRQDGGGARGGGGGKVRAAAAKRKGLSESILPAQLVAQVVADRMQQLRGQPQQPALVGRGGGAGGSQGTKHRPMAMVRPTQLVVDTDGSSDEEEQQSGQEDEELGADVDCVDEEQDDEEQDDEEEEEEEPDEEEEPVNPSSKRRTARRTADTTSSLHADEDEDEEEDDQDVNMDSVEAGQDDAGDSWPVEDEEDGEDGGEEEEVLEDCEEAEEEEYEQGQGEEYATVEGEEDDDYYYANGMEQEGEEQEEGIIEVDDEEDANEFAEHEEEDEDDDVQEVIDVEEHEDAQLLKIKYMNQHAAGGRQHQWNGGAASGSGMGATNNNTINGKHGQQQDQDVIYTGTRTNPQGDRDREQEMIRITTINTKVKLCEEDKVSLDDFQLLKVLGTGAYGTVFLVRKLTGIDRNKIYAMKVLRKCVVILKEKTAEHTRTERQILEAVIDAPFLATMHYAFQTESKLYVVLDFVIGGELFTHLFKRESFTEDEVKIYIAEIVVAIEQLHKLGILYRDIKLENILIDADGHIVLTDFGLSRELLHVKERAHSFCGTIEYMAPEIVKSRHNDGHDTSVDWWSVGVLTYELLTGVSPFHNDDGQTEISRRIMEDEANIPSRLSDAATDFIRKLLTKDPRRRLGSGKQDANELKMHPFLRDTKWDLLVAKQVAAPFKPVVTSETDTTYFSEEFTQQESVDKPCSPPKNGHRLFRGYSFVSPKLLSCKVYDRNKFVPIHNTRPQENLIRKSASKLYSEFFKKYELTGDQAIGVGTYSVCLKCRPVRPDQQGTIYAVKVLFNHAETAGYAQREAAALRHCQGHPNVVRFVELIEDRNYVYIVLELVDGGELLQYINDCPERLTEAQVRPLFHQLVDAVAFIHRCGFAHRDLKPENILLERGGKRGSVRLRVIDFGFAQALNGDDASDRISSWEPAGTLGYVAPEVVSQSSVLPYALEAADLWSLGVILYTMLSGQPPFIPQNFVGHDNLASTAKQTELITSNIRRGLFDLSNSTWQSVSDSAQDLVRSLLTVNPERRITMQELQDHCWLLQQKDASDIMPVSSSSQRHGTRKPFEQLRQAVRNTFDAFKKAEEKGFRLQGEVSSRLRLANTTTTAPENNSYKPMTTTTVPNNSNSSSSSSRKNGADRTATKSTTAVSGKRTTTVPEVSSTKSIESQYSSSMEESTSSGIGRSKSSKSSLSLSGSPMRDRNLSNGSCVVILDDDDEDEEQRPVHVEIKTPTTDVVVSPVCDLVVETPLLKVSADAEQEQQHSHDQKTLEELSEEVTKLSEEQEETDEIAVDVEDDEANVRTTSEEKQQPDEELVTESSSTEALTTTEESNNNEVAVVMEEQEDTTAKEHNHRHRIPEEEMASSKEATDNQPNLTEEVSDQLPTVVSNDDVAFIIEGETLSTAELSEENGIIIPLDIQGEAEIVVGQYVISLQVPEEKVINRRSQMRVRFEDSRTSVSRRRSRNASPPSYGAVADGVRDWKRIVDLSPEGMVKKEAEFRSCRGYEMFAFVCYDPDRRLPRPTDGPSDDPSDDDDAAAGVLLGFDEWEADGPFAGFSEEECYRFFGYYEWELAVKHGKRRKREPQLPERITKRRREISSYEEIDVRPKRRCTDYAYYGTSKRLMRTLARMKQEEEKFPPVEILSAPPPPPQSHLDGAGLGFMIKPEHDWLKKNRMESVWTVGGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDY1</accession>
    <name>A0A084VDY1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP003559-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011921">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524735">
        <property type="protein sequence ID" value="KFB36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDY1"/>
    <dbReference type="STRING" id="74873.A0A084VDY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003245-RA">
        <property type="protein sequence ID" value="ASIC003245-PA"/>
        <property type="gene ID" value="ASIC003245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003245"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014184"/>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13359" checksum="105BA5B9819EBA27" modified="2014-10-29" version="1">MMSMTHSDQHQHHQARRRTMRMTVARNLLLLLAGCLAALLVSPARVSASAIPAASFPSTNGLANSASVDVGGQRRATSCVAVHPILKRRGVDPIDMPIDPIPARDRMRIIGCRCVQLAVSYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE36</accession>
    <name>A0A084VE36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003341</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012227">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524773">
        <property type="protein sequence ID" value="KFB36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003341-RA">
        <property type="protein sequence ID" value="ASIC003341-PA"/>
        <property type="gene ID" value="ASIC003341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003341"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13650" checksum="558C2EEB2CDF93BC" modified="2014-10-29" version="1">MTTGRRIVTVKKREGKPVTHSDSDSLLPQGKNEKTNGPTRPASRSTDQTDTAPAALGPNWTPKEPFVQSSSERSRGRIARTQGRTRWRRKNLVHTTAAPFRPCRFPPRPPAAGGQRKELPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE60</accession>
    <name>A0A084VE60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003370-RA">
        <property type="protein sequence ID" value="ASIC003370-PA"/>
        <property type="gene ID" value="ASIC003370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003370"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003370-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9910" checksum="2402190CAAF4DBD5" modified="2014-10-29" version="1">MLHPAIFPQPETHFNPSNRGPEEEGSERFLRLAKEIIALPYDHHPSRPHTRAAARAKWAVWEFASAYITEQAPQQHFKSTFTMVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEB1</accession>
    <name>A0A084VEB1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524776">
        <property type="protein sequence ID" value="KFB36305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEB1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003426-RA">
        <property type="protein sequence ID" value="ASIC003426-PA"/>
        <property type="gene ID" value="ASIC003426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003426"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="9002" checksum="7A4D65C8DC659F05" modified="2014-10-29" version="1">MLTLGPRWDVNESEKIPVYWPTPVPSGPGQRPDTGTELKPEWPELEPPKKVPECRWVMIAHETFTCAHLLPPSPSEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF34</accession>
    <name>A0A084VF34_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cullin-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00003771</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15 16">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF34"/>
    <dbReference type="STRING" id="74873.A0A084VF34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003771-RA">
        <property type="protein sequence ID" value="ASIC003771-PA"/>
        <property type="gene ID" value="ASIC003771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004328"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000008">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000059">
        <property type="entry name" value="Cullin-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="17">
        <location>
            <begin position="330"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB36578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="687" mass="80504" checksum="03E8FA9245C5E71C" modified="2014-10-29" version="1">MSKRIEYSLEELYQAVENMCSHKMDSQLYVNLTALAEQHVKANIIPFLGESGDKLVYLKKMNEYWQAHCQQMIMIRSIFLYLDRTYVLQNPTVHSIWDIGLELFRDHIAQNGLVQSRTVEGILILIEKERHGETVDRTLLKSLLRMLSDLQIYRDAFEQKFLMATKHLYQSEGQAKMEELDVPEYLQHVDKRLQEENERLLHYLDSCTKHQLIVTVERQLINEHVTGILQKGLDQLLEENRLPDLTLLYQLFSRVKNGTTELCSHFNAYIKKKGRTIVIDPEKDKSMVQDLLDYKDKMDNIVNTCFERNEKFGNSLREAFEYFINQRSNKPAELIAKYVDMKLRAGNKEATEEELEQILDKIMVQFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINLTFRQTMQNSENKELQNIDLTVNILTMGFWPTYPVMEVTLPQELLQYQSIFNKFYLAKHSGRKLQWQPTLGHCVLKAQFDAGPKDLQVSLFQALVLLLFNFNLTISFEEIRAAVNIEAGELKRTLQSLACGKARVLTKIPKGREVEDADKFQFNNEFTNKLFRIKINQIQMKETTEEQKATEERVYQDRQYQIDAAIVRIMKMRKTLSHNLLITELYKQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFQ7</accession>
    <name>A0A084VFQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003963</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003963-RA">
        <property type="protein sequence ID" value="ASIC003963-PA"/>
        <property type="gene ID" value="ASIC003963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003963"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003963-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="15058" checksum="F4690A3E5DD2C0E0" modified="2014-10-29" version="1">MPAALTDGSLGVSSPANVQEPARLRALISCIHDPQARSLSHGASERARANGYGWVTDNFPFVDAENIRCTRSHQSPVNAVHVFRTGRLVRSRRRICNAQARGGPLVSTASTRFRARPHHHHPALRDPNCGAVPTPNSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGF2</accession>
    <name>A0A084VGF2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cyclic diguanylate phosphodiesterase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004233</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB37046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004233-RA">
        <property type="protein sequence ID" value="ASIC004233-PA"/>
        <property type="gene ID" value="ASIC004233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004233"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KFB37046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11599" checksum="B965CA93893559E9" modified="2014-10-29" version="1">MAAHRNGKDRAEAGGSSTATVTSVFDLIGSLDEDTDVSSINQYCNVLMLHLHQSVSLLAGHCHCLWLVKGMHVACQRYSYMCDDAIKVSFCVANFVYPSDISGRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGI8</accession>
    <name>A0A084VGI8_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004289</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004289-RA">
        <property type="protein sequence ID" value="ASIC004289-PA"/>
        <property type="gene ID" value="ASIC004289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004289"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5346" checksum="0FA490A537DC77AE" modified="2014-10-29" version="1">MTDSGAGPRSGCGFSSPKQQQQQRIRSQSCGPAGCSGPINNVPRLLSSAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH80</accession>
    <name>A0A084VH80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDEase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004615</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH80"/>
    <dbReference type="STRING" id="74873.A0A084VH80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004615-RA">
        <property type="protein sequence ID" value="ASIC004615-PA"/>
        <property type="gene ID" value="ASIC004615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004615"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002462"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14684" checksum="2C03B0ED84CE8F61" modified="2014-10-29" version="1">MPHVFQNVIKLWIITHPVVITTRGGSHDRTHLQLHARHMYAITWHTNLVQRLGELEVLVLLVACICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFRNMSKEMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIH6</accession>
    <name>A0A084VIH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008891-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005086</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIH6"/>
    <dbReference type="STRING" id="74873.A0A084VIH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005086-RA">
        <property type="protein sequence ID" value="ASIC005086-PA"/>
        <property type="gene ID" value="ASIC005086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005086"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021468"/>
    <dbReference type="OMA" id="VEEQFCA"/>
    <dbReference type="OrthoDB" id="10004439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783525" evidence="9">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="28516" checksum="25B0123B9080C1C8" modified="2014-10-29" version="1">MLRNLLFSILLQVIITTAHHCVVAIGWTRSNESIDYLCGGTLITNDFILTAAHCVGDSDNISPDTVRIGDTDLGSPEDDEFAQQIAIARFIPHPQYRGSRRYFDIALVQLKEPATYTSAVCNACLWRELEIPSGPMDAIGFGATGFGEALSPTLQRAELNMIDMANCTKRITLSRRQMPDGFRTDQFCAVGNSMDTCEGDSGGPIGVKRLDVQGYVFALIVGVVSFGTPCSVGSTGVYSKVSQYADWIEQVTNTSFDYIGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ23</accession>
    <name>A0A084VJ23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP000076-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00005137</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ23"/>
    <dbReference type="STRING" id="74873.A0A084VJ23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005137-RA">
        <property type="protein sequence ID" value="ASIC005137-PA"/>
        <property type="gene ID" value="ASIC005137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005137"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002143"/>
    <dbReference type="OMA" id="QLCQHIP"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11394">
        <property type="entry name" value="bHLHzip_SREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="392"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB37967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005137-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130397" checksum="58CEAE0A480358CC" modified="2014-10-29" version="1">MDQDRVWNDPFQPPGMYFPATVFKEDELDMNDMSDIGDITDMYQLNEEKLINIMGEDFLTNYSWEDGPSMNVSASSTAIGSASPGVTVKEECVASDTASAMSTEPSLYQNLVLPNDPMLLATTPMTTSAEPASPQQATQQQQQQRSKEEKKHTVLQPLAPAPPQQQQILPAPPQIAPQQVHLQPSQIVTGPRSVILTQNGAAVGPAGAQTLLVANANGLGSVGHTYTAKKIAPATQAQQQTTTRTLLPGLSNVRLQNLSQQTVATGGGAGATATMPVMQQLFALQTGDKQSAVFLQANTPVIYTSANVHSIATTTATVKANPANIHTLVNTLNGPVLTAGIPVMLDATPPPQTERPKVQLNRLQPATAASPGSSSSSGIGSPGIGVPKVKEVKRSAHNAIERRYRTSINSCIVELKNIVVGEEAKLNKSAILRKAIDHIRHLQKQNSALRQENMSYKLRFTDQKHTLKDLLVSQPSAADEMLTTAPITPPRSDESNPSSSPTHSDSSMPGSPFGGSSSVHLSTAGSPSGCDDLLDDDLMSGIGGMSANSRLTICMFMLAVLIVNPFGSLLSFASDDGDGRLYEEMGTQRRILAVEESFSWSRISSSLLLALVNFIFLALCLVRMLVYGDPVLTPRSRASTDYWKHKRQSDVEFRRGNATESYREAKLCLQSFGLSLPSTRLECATATAWQFVRMFFHRLYIGRWLSRRTGGLFKPEGERMHALHSARELALLYHRLNQLHLVSDHTDANGLMMSLCAVNMAEAAAGVLSVDDTIEIYLLAALRVKRSYPRMMQYFCRYYLGKAKQLASDHTSRKFRWLFTAYGFQFLTASSTFRYEERLGDSHETFTRLCNKADPLEYVMREYRLNLLQKAIQLLVGSGRDAHGQGRLVASGSDAAGLQAAGKEPVPFDACVLHGNGCFDQLAHWWSNLLSVAAFWLLGEDERAEALYGHVENIPAELRQPQPDPLANALLVAFQVKRGLITKTESDFATIFEQCNASSRLLEDSLTGNICKTPSRLKLLAQLLACDWLLESRTALWEMENDMRYYQDYLTVPGTILAAFQADLNLLRLVTSKFPNAQSRVFLYEAICRLMAGAAPGPTQQLLDRSLRQRNCRSSLICGKDRSAQLEGGRERAAALYVACKHLPSPCLSSPGERAGMLEEAAKTLEKIGDKKRLQQCYQLMKSLGSGSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJE2</accession>
    <name>A0A084VJE2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Exonuclease V subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJE2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005360-RA">
        <property type="protein sequence ID" value="ASIC005360-PA"/>
        <property type="gene ID" value="ASIC005360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005360"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6427" checksum="9F931A83316DABE6" modified="2014-10-29" version="1">MYAGTTPFVRRRGTARGSTGERAHQHQDHLEPARAGEVRGTLRGSLRDKVEPEGKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJM2</accession>
    <name>A0A084VJM2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005473</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013776">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524891">
        <property type="protein sequence ID" value="KFB38166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJM2"/>
    <dbReference type="STRING" id="74873.A0A084VJM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005473-RA">
        <property type="protein sequence ID" value="ASIC005473-PA"/>
        <property type="gene ID" value="ASIC005473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005473"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021818"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="1">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="32026" checksum="6627AAB835C44A19" modified="2014-10-29" version="1">MQQFVLINTRSFCEYTEDESKKQTRVKSPSTGFPHQATLQVETIAGRLRSLECTVSVPVVRPECVLPTAHTTYSTVCRSVQCVPMRRMAPPANVYRDLVVPAKASRFLADVFIPPVAVKTPKLDNSIVNRYLSVADEDFVYCVDLDIRRFIERANPKAVLIFPPFNNYRRFLIHKVCASKAFSQHDVVTFSIGVGTERRTVVCFRHQLLQDVKSASTGKRLHPPKWPSLLRKRSLGRIWLSVCADQASVDSRAVTIVWGQFRTYDTITGRGRCLSMCDACLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKD3</accession>
    <name>A0A084VKD3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP003658-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00005790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKD3"/>
    <dbReference type="STRING" id="74873.A0A084VKD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005790-RA">
        <property type="protein sequence ID" value="ASIC005790-PA"/>
        <property type="gene ID" value="ASIC005790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005790"/>
    <dbReference type="OMA" id="EFEYSIV"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8748" checksum="C42930F549621958" modified="2014-10-29" version="1">MVVVVVLVFAFCWCPIQVILLLKSLKLYELTHASIIFQIVSHVLAYTNSCINPVLYAFLSDNFRKAFRKVTARLNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL04</accession>
    <name>A0A084VL04_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006068</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014393">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006068-RA">
        <property type="protein sequence ID" value="ASIC006068-PA"/>
        <property type="gene ID" value="ASIC006068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006068"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8484" checksum="69998A98B4B8A151" modified="2014-10-29" version="1">MLRAGIGPMQMASTAALAGWANPLAPAGSVTRLPFFALSLSPEAPKTTPPNTSGHRTDGECNAFAQLEGKTMRQLDTITNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLC4</accession>
    <name>A0A084VLC4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00006170</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="ATLV01014444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLC4"/>
    <dbReference type="STRING" id="74873.A0A084VLC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006170-RA">
        <property type="protein sequence ID" value="ASIC006170-PA"/>
        <property type="gene ID" value="ASIC006170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006170"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013461"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB38768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="541" mass="60278" checksum="1F0663BAA80F6091" modified="2014-10-29" version="1">MEPHVRLVTGSIDRVFTGRQPWQIVAITTTTVLGTIWLWQVLFQEESVYQRAKKKVFKLARLIPAVRRRVDAEIEKINDGFVKDISQKGNYYTELPNDGMEGGEILKKVDDYLELGHYRWKEGFISGAVYYYNPELIKLVTEVYGKASYTNPLHPDVFPGVCKMEAEVVRMTANLFHGGPSACGTMTTGGTESIMMACKAYRDYARENRGITKPNMVLPVTAHTGFDKAAKYLGIFTKVVPVYADSTEVNIAAMERAINRNTVMLVGSAPNFPYGTMDDIEAIAELGRKYNIPVHVDACLGGFLIVFMKRAGYPVRPFDFSIPGVTSISADTHKYGYTPKGSSVILYSKKVYRHYQYTVTTEWPGGVYGSPTVNGSRAGGIIAATWATMMNFGLDGYVEATKRIIDTTRYIEQQLRAINNIFIFGTPATSVIGIGSRDFDIYLLGGELNSLGWNLNSLQFPSGIHICVTYMHTENGVAEKFVEDVRTKVALIMQNPTKPVEGKMAIYGVAQSVPDRELIGDFTKCFIDSMYYTPVDKQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMD0</accession>
    <name>A0A084VMD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIH1_CS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMD0"/>
    <dbReference type="STRING" id="74873.A0A084VMD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006453-RA">
        <property type="protein sequence ID" value="ASIC006453-PA"/>
        <property type="gene ID" value="ASIC006453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006453"/>
    <dbReference type="OMA" id="ESMVVHK"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="188" mass="21791" checksum="3A2A0B9DB2A42B0F" modified="2014-10-29" version="1">MRKQHQQTFHNLVRKAWPGDIGELPAKPRKKASTDGSEHVKPCSYTPLEAPVEVQPKTLEEWELEQQKNEDHALLESRRQPQYRISYRQTVATEDIYLQMNCKTPSTASCENMIVEILFPEEDATIGVHHIELSVKEQCVTVETPKYFLNLVLPHKIDPDKGNAAWHSDQKTLQLTLRMVRELDFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMG3</accession>
    <name>A0A084VMG3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transposase, IS605 OrfB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006492</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006492-RA">
        <property type="protein sequence ID" value="ASIC006492-PA"/>
        <property type="gene ID" value="ASIC006492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006492"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9212" checksum="E9ED7E94A3B27BB1" modified="2014-10-29" version="1">MVASTESRPHAESRCDGGCFENIIYGITFSLTPKDSILRFAKEFEESAHALNRECRKLNAKAIKNRNHQRFSYGFLMLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNU9</accession>
    <name>A0A084VNU9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Lipoyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524996">
        <property type="protein sequence ID" value="KFB39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007090-RA">
        <property type="protein sequence ID" value="ASIC007090-PA"/>
        <property type="gene ID" value="ASIC007090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007090"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018035"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19313" checksum="F8936D60CD3FCF25" modified="2014-10-29" version="1">MASSGTRSPRKRLSALVGLLPHQCCSARRCRHHETTSATTIVTTAAACVAASITPLRSLRPCRDGVCAISHDYTVSLCRFPSFGQYGSRSCIRSPKSVRWKDRLGDELLALSDTVGLAMLRNGIRCRVGQMDGRFGSPPLQPWWKKGASDAFPREDPAVDQGRPPTTSIAFPPSGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNW0</accession>
    <name>A0A084VNW0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP000273-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007102</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524996">
        <property type="protein sequence ID" value="KFB39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VNW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007102-RA">
        <property type="protein sequence ID" value="ASIC007102-PA"/>
        <property type="gene ID" value="ASIC007102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007102"/>
    <dbReference type="OMA" id="EVYIKAM"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="4">
        <location>
            <begin position="51"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="3">
        <location>
            <begin position="279"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="1453"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="1593"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1747" mass="196520" checksum="70C36DDA5D6758E5" modified="2014-10-29" version="1">MENQDERPEEGKKSVSAVIKQDQNLIAIVNSLLDSLNDKDELLRSTTEASLIRIAKRRHDEIVEVLCEYRKKHPKLGDTHTLIILRVISYIGANLIDVIDPNTASKCIQYSTTEITKNTDQNAAIQNPCREILVAVGRRYCKEIMEIFVKHLEENQLGNFMIMQSIGALATANVRDTVPYVKAILGLILPTLAIIKQDFLRQAYAYAIGRFCEAFSEYQEYQRQNPNTDEIPMTTVVRYEIHDEISIIYDHFHAQWLSSREPKVTGEVLNAFSFMYPLLPVEKVSDQLPKTLSLVMALYRKSLDRSAITQYLASIIKTVLQLNSKLLAPTSDNLIVCLFDLVCVNPDYDKPQTVKGHFEVLRCFDLLAPEYGEKIIEILIIHLRNNNERERIKSLLVVTHLTNTSEQVVHDKLPEIIGILKGMLATEKPIKVKIVLLKTVVAFMQKNFVQDREFVTFLIRSSCRPAKLNLDHGTLDEHQEFQRACNDTMHILSSTVGTVDAMLKLELLQAYLRYEYTDICGTIGKCLANLFTKDPELTVTLCERHNPFDENVQATEEVPPPPRPVAVFVRTLALLGNYSEQGRIQHLLTFLRSYAGCLYRQLVPLWLERTTALQTELASGIDERRYYELLFQFLQATIKDVDEYKFVESIIAEMFHQLPLYQAPGMVGSGGPSSGAQTLEFRVPSLEQEKRMVVKVFGVCLCHSLDEHLIANKIDLIVTMAKGERCEKNAPPEEFERLMQDYADALGYASVEHLDKVMAKLTALVIDEGAVKKSSSFFSNLNFIKDSAREQEAYRLKVLALQALHVIISRAPREKVAQYYTDQVVRYLIVQFDSKELFIKQLVVSTLLALTDVFSPSDGDERMTSLRNKNDLHRICMATTTDHQSNEYLPLFPSIIQLATVLVQLNAEEQPGLDVNGLLNSICFYFFTTAQNLKSRFDSAEDDTRNSYLARFLNLSLPEVNRFIRTLLVQQNASPACLDDVHSILEKWLKDRNSEVRICACHVYNSTLEVYMKSMKIGCEAPSKFNQTGSMLGKIIPRCIDSNATVRQTAVEVLKKILEIACVYETLTVADSSVQWVAELDRIHEEIVTDDAKDIYRIASELAQIIAQRLSNYQYVQFSKCLLYGVADPEPSSVIGASYVLKFFMHVKGSEMFHAIPELVKECLYAVKICEVPRAKTTILKSILALTKHHPKLVCNEILSQCLPLEEHVVEYWKTLTMDPDLSGTILDNFIVAVTSSCLYEQPQQQQQDTPDTTDDTTRTATMHPFAIVCVLKEMFKCDELKAEMRARFAEIFCMLLSTLASYITLLPPYSVLAQPNVAGNVTIPKSARRAKGQLAQGPGKETIAKLNPCQTILDAFQTFLDTLDMQQISIVLSVCPDLAASTDLNSFIEILTPLGVATASEVGINSALMRQLVTTMSRYVSSPYDTQRIASTGFYAHLVPLQPCGETASVIMLSLESSLNDPNPLVRGLSIRGMAYVCSLTQHDIDKYATMCLTSLLKGIEDYNKNCFINIPLDSMRGLSKILQTIEPAKFEPFQVSSAIRIRPFFEKNSTELRESAILLFGDVCGLKVKQMVVASNDSNSANGGADDTLVSESLMEQLKANFCSLLLHLCEQSSMIARACKITLKNICAVLGTPKMNALAQNCLIEHGQLQYNNFLKSFVKLIGEELQECVNDFIDACLPLLRSQWPEIRGNAAILIGLLHCQNATVKCQHMEQIGHKISLLLKDDCMSVKVSASEALGYIYGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP55</accession>
    <name>A0A084VP55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007886-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007443</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014978">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP55"/>
    <dbReference type="STRING" id="74873.A0A084VP55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007443-RA">
        <property type="protein sequence ID" value="ASIC007443-PA"/>
        <property type="gene ID" value="ASIC007443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007443"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002040"/>
    <dbReference type="OMA" id="MDRISTK"/>
    <dbReference type="OrthoDB" id="8193882at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF14">
        <property type="entry name" value="GEO07393P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18667" checksum="0A5C5976C2A17378" modified="2014-10-29" version="1">MQCGVETMNDCERSPGRTGLRVNFTEKGEVKERREKFLTAKYGSHQMSLIRKRLAVEMWLYDELQKLFDPPVSRPPIWPSSDELVGQLINTSPRVFYTLFFSDPKPQTGGLQTEAIDVDIDEILDMDTDDIRRSHLFVSIFYSRRISRIGSDNGQAEETAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPI1</accession>
    <name>A0A084VPI1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adapter molecule Crk</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00007251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRK family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPI1"/>
    <dbReference type="STRING" id="74873.A0A084VPI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007251-RA">
        <property type="protein sequence ID" value="ASIC007251-PA"/>
        <property type="gene ID" value="ASIC007251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007251"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022168"/>
    <dbReference type="OMA" id="SMTRQEA"/>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09926">
        <property type="entry name" value="SH2_CRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11759">
        <property type="entry name" value="SH3_CRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11758">
        <property type="entry name" value="SH3_CRK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035458">
        <property type="entry name" value="CRK_SH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035457">
        <property type="entry name" value="CRK_SH3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30379" checksum="3FA7A07C14DFDD80" modified="2014-10-29" version="1">MASFDVFDRSSWYFGAMSRQDATDLLMNERESGVFLVRDSTTIAGDFVLCVREDSKVSHYIINKIPSGEECFVYRIGDQTFGDLPDLLSFYKLHYLDTTPLRRPMVRRLERVVGKFDFDGSDPDDLPFKKGEVLYIISKDEDQWWTARNAQGQTGQIPVPYVTRYEENIIERPNSGGGGVGHHHHPAGGMHHSENSNIFKSNLNRQLPALARVKQERVPNAYDETALKLSVGDVIKVLKTNINGQWEGELKGKIGHFPFTHVEFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRC7</accession>
    <name>A0A084VRC7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP003023-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008014</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRC7"/>
    <dbReference type="STRING" id="74873.A0A084VRC7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008014-RA">
        <property type="protein sequence ID" value="ASIC008014-PA"/>
        <property type="gene ID" value="ASIC008014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008014"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019329"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="588" mass="67006" checksum="2A3E7C88BF8E8BC4" modified="2014-10-29" version="1">MALKLLVGQKIMNEVVRSKTKADGKPGTEWRILIVDKLAMRMVSACTKMHEISAEGVTLVEDINKKREPLPAIEAVYLITPSEDSIRLLMRDFENPAKPTYKAAHVFFTEVCPEELFNDICKSVVSRKIKTLKEINIAFLPYESQVYSLDSPVTFQCAYSPALASARSGNMERIAEQIATLCATLGEYPSVRYRSEWDGNVELAQMVQQKLDAYKADEPTMGEGPEKARSQLLILDRGFDCVSPLLHELTLQAMAYDLLPIVNDVYKFIPSPNAAEKEVLLDENDDLWVDLRHQHIAVVSQSVTQYLKSFTESKRLTQSEKQSMKDLSQMIKKMPQYQKQLSKYSTHLHLAEDCMKSYQGYVDKLCRVEQDLAMGTDAEGEKIKDHMRNIVPILLDQNVSNYDKVRIIALYVMIKNGISEENLTKLVSHAQIEQKEREMIHNLTHLGINVIADGNRKKPYTVPRKERINEHTYQMSRWTPVIKDIMEDAIENKLDERHFPFLGGRKMAGFHAPTSSARYGHWHKDKSQTAVKNVPRLIVFVVGGCSYSEIRCAYEVTTAVKNWEVYIGSSHILTPETFLHDLGSLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS09</accession>
    <name>A0A084VS09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Hvp 53 VSH-1 major tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008181</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008181-RA">
        <property type="protein sequence ID" value="ASIC008181-PA"/>
        <property type="gene ID" value="ASIC008181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008181"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008181-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9524" checksum="DC92D20BD4A12720" modified="2014-10-29" version="1">MTVASRQHPVALQGGKEWVGVEVCLSKDAATTNVVVEKYEIVIAKNDYVPLLAFISAQEAEQPSKVSWLRMWLRPEKRKGAAYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSC7</accession>
    <name>A0A084VSC7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003525-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008429</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSC7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008429-RA">
        <property type="protein sequence ID" value="ASIC008429-PA"/>
        <property type="gene ID" value="ASIC008429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008429"/>
    <dbReference type="OMA" id="WINGLFP"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="491"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="632" mass="65277" checksum="4DAE81A2A2D5516B" modified="2014-10-29" version="1">MQVMANLNFQQPPRSIPSSVSLSGRGGGGGGGSSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGSVGGGGPFGQSAPSQQQSNQSSSSVAPLSPSTNGGNPRSGGATGLMGGGNGGVGGGLASNGPSSGQQQQLSSSNAASGGGRSSNLFGGGGGQQRGGVGAGVGAGGAGGFADRRTMSGLGGTSMSNMVSFMQSRGYGSQSGNSINNYHGVFVDGGATDTGTPPLLDLTEFPSLTNARGGQNDQSLPQSNALQPPGSKPYVGMVKQPTSEQIAFTMSNEDFPALPGTQNAEGSQMGAASQGLQGVHHHHHPDHHGGGGGGGIGGSDSLGGKGSGGGSGGPVGSAAGMGMDLQSDSGNSNVNMDKGAMKRGVQTSPSGSVTNIPASMVNNQFGMVGLLTFLRAAETDPNLVTLAMGQDLMALGLNLTAVENLYPSFGGPFADAPARPQDIDYNVPPEYLINMSIRDKLSKLTLQKYKDDLLFYLFYTNVGDMMQLAAAAELHSRDWRYHTEEKVWITRVPGMTPYEKNGTTERGTYYYFDAQTWRRVPKEFQVDTVKLDKCPNISAYVAMSGQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSZ0</accession>
    <name>A0A084VSZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008540</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008540-RA">
        <property type="protein sequence ID" value="ASIC008540-PA"/>
        <property type="gene ID" value="ASIC008540"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008540"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9594" checksum="39E82F37916142D0" modified="2014-10-29" version="1">MGDVCGSVCQRWCGHGGGVKTPSPVQQTRHLQSDFGRFDLSFPDPKPPFLDERHLSRVNRDRFSSSSIRSWIGFDRPRRGMAGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTS9</accession>
    <name>A0A084VTS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010410-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008954</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016468">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525091">
        <property type="protein sequence ID" value="KFB41373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTS9"/>
    <dbReference type="STRING" id="74873.A0A084VTS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008954-RA">
        <property type="protein sequence ID" value="ASIC008954-PA"/>
        <property type="gene ID" value="ASIC008954"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008954"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020938"/>
    <dbReference type="OMA" id="AGGTMQM"/>
    <dbReference type="OrthoDB" id="5982619at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008954-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="697" mass="65785" checksum="3377E9C89F636AAB" modified="2014-10-29" version="1">MGGVPGGPGGMVGGQGGGAGGNVGGPQTTIPNGPGSGLNSGGSGSNGGPNGGGPGGPGVPHGANHQPNQVPNSQGSSMVNEAQYTVSQSQTINFTQQTLRARQQHQVNGGGVGMPNGGAGGPQHPQQQQQQQSGGPGMGGGPASNQPTSQQQQQQGAPSGPQNQGLGGPGGGPGGVGGPNGPGGPGMGQGNGAVPLGAGMVGPGGMAGPGNGGVGMVGGPNANVGMGMGGIGGPNGGGISGLNSMVSNSIGPGVVAGAGGVNGGPAGMMHAGMGGPAMQQQMAAGVRPPPPDYNKAAQQGNPAAAAAAAAMMQQQQAQQQQMLHAGGRFPAMRRITQQPIPPSGPMMRAQHAAYMQQQQQLAGHGPRGGGMVGGFGGPGVGGGPVGGVMPGGGGAGAGGGAGAGGGVMGGPVQRPPNVQVGPEGMPIGSQQAEWRHMMAMQQQQVAFNASSGGSMRQGFGGPGAGPVGGPNVAGPIARMDPSVGPVGPAGSGGPGGPIGAGSGPAGAGGGGGPGSGMGPGGPGGPGSGGGGMTAMQMQMLRQQAMYQGAGNNGPTGGGGGGGGGGAGGVGGGGGGGGPMSQMQMLQQHQQLQQQQNMMNQMQMSQIHMSQTQTMSIQQQQNQQSVMNTFTAQSTQQSTTTTMIAGGGGPGSGGIAGGGPNVVNAFLENLPVGDPSQFNAQDLLNSLDNDSFNLQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU77</accession>
    <name>A0A084VU77_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009126</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016680">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525102">
        <property type="protein sequence ID" value="KFB41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009126-RA">
        <property type="protein sequence ID" value="ASIC009126-PA"/>
        <property type="gene ID" value="ASIC009126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009126"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009126-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="211" mass="23826" checksum="E41518012A3B4787" modified="2014-10-29" version="1">MAITTAWATTGSGGIGIGSDARVECRGRGDFTEQLPHRQDTANKYGEQSNVVFHLSANSFASNLVRRRQNASPVSSGKRTGCCLPRICVTYKCMLCCVLACCALLLPKHMFPPLRQTEGLRRPLLHHLRHVNALPLMCFFAIFLSVFFRACGTGAAVECTERKCISIRVIKRWYERPTDERWNARETARSANPPGGFMLRRWRRATGRKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV25</accession>
    <name>A0A084VV25_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009658</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009658-RA">
        <property type="protein sequence ID" value="ASIC009658-PA"/>
        <property type="gene ID" value="ASIC009658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009658"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016534"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10118" checksum="4264367729575B19" modified="2014-10-29" version="1">MPPFAHHVERACKTDEVSRNWSTVPVDREPIFLPARICNRSEADSTPGGFCSGDPEPSKNVAAVCQSANDTANLPRRRQMMTNLSHAGRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV48</accession>
    <name>A0A084VV48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009683</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009683-RA">
        <property type="protein sequence ID" value="ASIC009683-PA"/>
        <property type="gene ID" value="ASIC009683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009683"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009683-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9941" checksum="51F3F75A5143C06D" modified="2014-10-29" version="1">MVGSWTAGNTSLLRALPAARKTAVLALARTRYPFNERALHVHGAGRCRWRSFIASHSRPLIFWLRVLEAGDGRGEIRALDNDLEWSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV74</accession>
    <name>A0A084VV74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Zinc metalloproteinase-disintegrin EoVMP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009713</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009713-RA">
        <property type="protein sequence ID" value="ASIC009713-PA"/>
        <property type="gene ID" value="ASIC009713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009713"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0401">Integrin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="20869" checksum="50794ED7B0D6204E" modified="2014-10-29" version="1">MALQRALGSFHRVPSFVRHGCLTANVNVCSLRFPAGYRLSLSAVRDGLPFPFHLPARSSEERPHGRGKCDESLCSTEQSSFPFTSSAECLSVRRTLQQAYGNSVGKPANLLTAFRKSVACQRIVAEKVSSASGPPAEADLSATISDWKGEFFHLQLPPHCTLHHPLLTDVRCVPVCIRGLLTASEPQEVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVG6</accession>
    <name>A0A084VVG6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000745-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009528</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVG6"/>
    <dbReference type="STRING" id="74873.A0A084VVG6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009528-RA">
        <property type="protein sequence ID" value="ASIC009528-PA"/>
        <property type="gene ID" value="ASIC009528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009528"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023134"/>
    <dbReference type="OMA" id="NVPQNYP"/>
    <dbReference type="OrthoDB" id="7222477at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009528-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="608" mass="67156" checksum="A9A7E2E40BB08B6B" modified="2014-10-29" version="1">MQDWLTLHVVHHGVRRETLGYWFTLAVGVVLIATVQLSEAQRRLRPRPRVLNSAEYADSAEEQQQDSRPQAQALPQYYRAQERLGGPEGGQQLVLVAASEEDYNGQYGTPTPRARADTQQQYQRPAAKSTTVQPSAARQKAPASESRAPPVQTIRNYSKVNDDGSFTFGYEAADGSFKEETRGTDCVVRGKYGYVDPDGNKREFTYVSGNPCDPNNPDGSEEEEAADDAPEDSNENVPQNYPRRPPVARPTQPAPVRPTQAPVRPTTTVFQNDYQDRRQPQAQVPESDEQEVQIGQRGGQRPAARPFVPTPTPTQRPRVQVLNTTPSPTPSVLYQTSTPAQTVVPVNITPKPVYRVSPLPTQPNLAPTTYRPASPSSTRGPSIDFEAEFKRFQQDNKLPSPSSAPATASTPSKPTGSPFGRPQIANGNPIYQSQLIFDPASGQYDTALYQQLPQSDGDFQLNHRIQPYVQAGPASHPASGQLVSLEQLQQQSPLYRAQPPQPSPPVARPPPPPTVQIPQQLYQKQQNELQFVNSQQLFAQQLELQQSQLRADRLEAAKKQVAAPGPLHRFQPQPQQQQYYFIQPQGPSPGGAAPGQIDAFLRGHNIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVI4</accession>
    <name>A0A084VVI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP000389-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00009549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VVI4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009549-RA">
        <property type="protein sequence ID" value="ASIC009549-PA"/>
        <property type="gene ID" value="ASIC009549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007288"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013422"/>
    <dbReference type="OMA" id="YYYLPYW"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000138">
        <property type="entry name" value="Fer-1-like family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000054">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2086"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="389"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="549"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1616"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1860"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1494"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2119" mass="237055" checksum="BE77720FC49A958D" modified="2014-10-29" version="1">MISDEKTQSVASDGSCLGGGLGNIGLVLPPDACSVLPGVAHTTTELNCGSEHVESFIWPLARAADEAETITVELRQQTTKILLKTGIGIASGGGNGSGGPGNRGSITSSTKIIGRFVMLAQALINEGRLRIEDRLVDLSNKPIDAYVSFDVCYQSPEDESGNFYAPRVVHSLHQQSSIDDDQQMLLDIEQNIANLEKSLSQSKTADQPSSSRTRSSRAASSSGGGGGGGSERKPNIIKRVMSSGSGIGERTGGPASNQPSDHASSDNEASARPAKSISDKKVTLRTVRNFMRLGRSRHSSRESTASSTEDEGKSLITSAGHEREQSADAGRTSGEQGHGAPGTGAAGESPTSATGKGTVPPGGYENVSQTCSTHSNASSEGEDVTTNEKLKKLKSMAKGNDHLKSQDFQVCVTIIEARQLPGLNMDPVVCIQVGDQKKYTSVKESTNCPYYNEYFVFDFHMPPVMLFDKIITLSVIHSRKFMRSGTVVGSFKIDLKTVYDAPDHQFYHKWALLSDPEDFAAGPKGYLKCDVGIIGKGDTVKVPPKSEKDPDDIEANLLLPDGVPIERQRAKFIVKVYRADGLPRMNSSIMANVKRAFTGEAKDLVNPYVQVSFAGLTGKTNVKKASYNPVWNEQLVFTEMFPPLCQRIKIQLRDADPMKPAIIGTHYIDLKQISNDGEKGFLPTYGPSFVHLYGSTRDYNLLDQHSNLNTGLGEGVSYRARLLIAIRTEITDNVELFADKNVEVEPTLPICESSYCKNDGFFLFSSVLEASMLDKKVCDRSVYFELSMGNAGNSLDGHNESATNNMDDDEEPVSIDTTAYNSTTSACKPITHDKNHYYLPYWDYKPCMDVRAWFPDLRRRMYNSNMISKITERMEVGLAETNLLLEEEDPTAEVKLRGVLEEVASSCNKYVTITKGALVGPGTGKTKLDKERIKLCQREVESIGNMSRNLRALVTKSSMKERYKTAQNYLAKLKFLIEDPQHALPDVFVWMIANGKRVAYHRLDARDLIYSTIEEETGVFCGKVQTVFLKLPGKQADGPAGWHVRAKLSLYLWLGTLKHKKFFYSGLPRGYEMLHELKNAEKSNVPAPTTIHYVEKYVFQLRAHIYQARSLIGSDASGLSDPYATVYITEYSKTTQVIEETLSPTWDELLVFDEITIYGSKEEIKRDPPTIVIDVYDQDKVGKSDFIGRAIAKPRIKLKENHYSTPVLEWFEITRGLDGAGELLAAFEMLEHGSEDVPRLSDPKYIAHGEYRGAGETSTSIQPALTILPVPQEVRPNLARFRIEVLFWGLRDLKRVHFMTVDKPRIDIECSGKIMNSSIIQNAKKNPNFANMLKFFDLDLPIEERYAPPITIRAVDCRSFGRYTLVGTHQITSIHKYMHRPPPKEDPKRFNQDGQVVLSRRRGSAGNLISPAADSAAVGAISNSWSGENLTLYGAAYVGKALHSKGKKAKKKLESQDASFDAQGGGGDDDDESSKDWWTKYFLSYEKLIESTKHSTSSRLMEQQQQQRNQQSHHQGGGHESAENGRKLGVKTSKFVSKLSPKSTPQKSCPAGSRVATCKIYPNELESVYEFNDFKEWLLSFPLYRGKKTGDSTEDETRIVGYFKGAIKVYKLPIEKGMEPAFAPTLPLNDPIHVLVRVYIVKATDLHPMDLNGKADPYVVLQLGSKRISDKDNYVSKQLNPVFGKCFEIEATFPQDSMLTVQIFDWDLVGSDDLIGETKIDLENRFYSKHRAMCGISTNYEDSGYNIWRDPMKPTQILSKLCKENKLEGPQYLQDRVTIGRYCFMFSTEEIQTWSNPTSIKYRDEHLALAVLHRWEEMPRVGCKIVPEHIESRSLYNTDKPGIEQGKLEMWVDMFPMDMPLPGPPVDISPRKPKSYELRVVIWNTDDVVLEDDAFFTGEKMSDIYVKGFGNFNWRFIFPFEYLAAEERIVLSRKESLFSWDETEVKIPARLELQVWDADHFSADDFLGAISLNLNRFPRGAKSSKLCTLNMLRTDNVPTVNIFKQKRVRGWWPFFIKKENDEMELTGKVEAEIHLLTKEEAEKNPAGFGRNEPDPLEKPNRPDASFMWFLNPLKSVRYIVWHNYKWSIIKGLVIIGLAILLLLFFYSVPGYTVKKMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW47</accession>
    <name>A0A084VW47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009861</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017441">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525168">
        <property type="protein sequence ID" value="KFB42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009861-RA">
        <property type="protein sequence ID" value="ASIC009861-PA"/>
        <property type="gene ID" value="ASIC009861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009861"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13518" checksum="DF7C9A48B5B3C787" modified="2014-10-29" version="1">MQTAKAGWPRATDDVMLQQQMTTATLGDALAINHVHVHGRRRRASERSEDEPPADWLHFRIWSAIASPLSLPIKSPCAPECSLCLEWWSEKEGEVADCTFSRHRRQGTRRIGGKLSELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX56</accession>
    <name>A0A084VX56_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010261</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01017849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX56"/>
    <dbReference type="STRING" id="74873.A0A084VX56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010261-RA">
        <property type="protein sequence ID" value="ASIC010261-PA"/>
        <property type="gene ID" value="ASIC010261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010261"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012848"/>
    <dbReference type="OMA" id="HWGEDNC"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF114">
        <property type="entry name" value="CARBONIC ANHYDRASE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="29264" checksum="BB9E6BE3F7AA14BC" modified="2014-10-29" version="1">MVPNAVQSPVCLSKSLSRMVDDAIPLRFARYFDDYHGGKAKLTNDGQTAVLTLGLQPALQPCIAGGPLDGVYLFEQLHFHWGPNDSHGSEHLIEGVAHAMEIHLVHYNAKYGSFRKAMERSDGLAVVAFLVHARGTVDCEDFLRITRELQHIVLPGSTRHAPADCMRWLAAQDLDRHYFSYRGTLTTAPFFASVTWIVYAAPVYVSHNQTAAFRMLRTFAGHCATEPASATRRIESNFRPVQPSEPAVTFARNTRRRMQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXM6</accession>
    <name>A0A084VXM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP006410-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010460</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXM6"/>
    <dbReference type="STRING" id="74873.A0A084VXM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010460-RA">
        <property type="protein sequence ID" value="ASIC010460-PA"/>
        <property type="gene ID" value="ASIC010460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010460"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008009"/>
    <dbReference type="OMA" id="FFDFQAF"/>
    <dbReference type="OrthoDB" id="7697912at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="318" mass="32696" checksum="58F2182A931D9A63" modified="2014-10-29" version="1">MTHIFSRFQFLTFRDGKFGVNFGGYHAEAGLGGLLTGNSAHGGLSASAGTPFGQQAGAGIGGLLGGNGNERTAGGAYAGATAGHGVGASAAIGGGLDGAGGAGGAGAESHAGGVSKKVVKLGQTNPGAPPTEVVISKEYGGNQHQGNFERIDNQHVKEVHTELTVPEPHPAPAPAPAHGFRKTVYKKKVIGHPHKIAVVETSSYNDGPQPPLDISRFFDFQAFTNLGAQFAHPAPPPPPPPPVVHKTFVKQISYEPIQRPTAGGSSTSTHVVASSTHNSNFWNDIFNIPISTLSAVNQFLNNKAGSGSLHVQKHVEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYC6</accession>
    <name>A0A084VYC6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010845</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYC6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010845-RA">
        <property type="protein sequence ID" value="ASIC010845-PA"/>
        <property type="gene ID" value="ASIC010845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010845"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8236" checksum="15DE15AFC2A91561" modified="2014-10-29" version="1">MDSHRSIGPNKAAGGQHNERANESGVHGTTKNQKENQCVEDGATIMQWLEYTRDCTKQKRTALVIPVSRRGLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ05</accession>
    <name>A0A084VZ05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010976</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010976-RA">
        <property type="protein sequence ID" value="ASIC010976-PA"/>
        <property type="gene ID" value="ASIC010976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010976"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8958" checksum="6FFF8BC8F9535F63" modified="2014-10-29" version="1">MASAGSNQPRSNISQLSCGELSNLLTWNFWYRAAASGTTPASWYRFSELPRPKVMFGMEMPTCVQHTDSAVQASRQQSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ32</accession>
    <name>A0A084VZ32_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ceramide transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Collagen type IV alpha-3-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011003</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)</text>
            <dbReference type="Rhea" id="RHEA:45720"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ32"/>
    <dbReference type="STRING" id="74873.A0A084VZ32"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011003-RA">
        <property type="protein sequence ID" value="ASIC011003-PA"/>
        <property type="gene ID" value="ASIC011003"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011003"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007145"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021429"/>
    <dbReference type="OMA" id="WSHMRRV"/>
    <dbReference type="OrthoDB" id="2344588at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13283">
        <property type="entry name" value="PH_GPBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08872">
        <property type="entry name" value="START_STARD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000003">
        <property type="entry name" value="Collagen type IV alpha-3-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000382">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041952">
        <property type="entry name" value="STARD11_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="15">
        <location>
            <begin position="372"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB43226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011003-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="585" mass="67111" checksum="E9F2C086B14F8A86" modified="2014-10-29" version="1">MADDYFVQNNSHSDDSEVELNLNSPELKGYLSKWTNYIHGWQPRFIVLKDGTLSYYKSEQDSDFGCRGAISLQKASIKSHEFDECRFDVAIGQNVWYLRAETPEDKRNWIEVLQSYKTDVPETVSLRRHGSTISLQSNTLSTASGSSLKRVSRGLREKLHEIETFRDILYGQIDTLQRYFDALHHKNGDQPPLDLGDGLKPIDFKGEAITFRETTAGVIITLQHCLDIISQKEESFKKKLDKEQERRRKAEELYRNCKDELAKNRNSVIPGPDLEEGPHSTIPEDEFFDAVETGLDKIEEDRQLRVRLKYQSQQLSNAGSVHSANLEAEDETVQLAEDFGTGAQAKCHKLWPEIDRICTEQLTQARQGVGEDGNGWQLFADEGEMKMYRREEEVDGMVIDPLKSCHVVKGVTAREMCHYFFDPAYRNDWETTLEDVQIVDNVAPDTLVFLQTYKRIWPASQRDALFWSHMRRITDNVDTGANDVWVVCNHSNQNEEYPPANQGKCVRIYLTVILVCQTYLTPGKDSKTATRDDLTCKITYCSTVNPGGWAPATVLRAIYKKEYPKFLKRFTGYVVDQCKAKPIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZA3</accession>
    <name>A0A084VZA3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00011083</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01018623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZA3"/>
    <dbReference type="STRING" id="74873.A0A084VZA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011083-RA">
        <property type="protein sequence ID" value="ASIC011083-PA"/>
        <property type="gene ID" value="ASIC011083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011083"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017816"/>
    <dbReference type="OMA" id="YYFVAAV"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF167">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="31217" checksum="95C722524AB66E53" modified="2014-10-29" version="1">MDLYEYYIYQNADQRTKDWFLAGSPFPIVGIIIAYLALVYYIVPWYMRNREAYQLKTFMGFYNLSQVVYCVFLIANLVKAGWRPYYFYRCVETDYSNDPKAVLMVETTWYLMMIKLFELLETVLFVLRKKQNQVTVLHVYHHISTFVIAYIYTKYIGGSMLTFSIVANCFVHIIMYSYYFMSAYDVPIFKFLVAKYKKYITKIQLIQFCLMMANNLLGLNPNCNISRPFLAMYIPNILILTYLFYDFYQKAYTKAKAAKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E8</accession>
    <name>A0A084W0E8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011422</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011422-RA">
        <property type="protein sequence ID" value="ASIC011422-PA"/>
        <property type="gene ID" value="ASIC011422"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011422"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011422-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7199" checksum="3D3FEB4AF244CC46" modified="2014-10-29" version="1">MLAPAKSNLQTICGTTRSRGEEHTERDGPMDVPVEFSSNSSVRRARGQRRPSPVEREDDDRQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0J4</accession>
    <name>A0A084W0J4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001150-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0J4"/>
    <dbReference type="STRING" id="74873.A0A084W0J4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011473-RA">
        <property type="protein sequence ID" value="ASIC011473-PA"/>
        <property type="gene ID" value="ASIC011473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011473"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009335"/>
    <dbReference type="OMA" id="RVEVCKN"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112615" checksum="A82AD67A6D9D9DDA" modified="2014-10-29" version="1">MSAEWICVARLQDECRRYLDRFKVFDHPLKQSTITVLESRGTRGKVTVPVNSNAPNSINPTTVTAATLSLDPLSIAFDGSDPLSQFAKQQETSLGKDPLSRMAAEMEDTVPVGKMAAVIGSTGTGTGKPKEPSNLLELDLIEPWAARRGAILNKYTTSEKLSIVTSFLTGGETIKPQTTMSEKVKYRLEQLDDFEDGSVRQMLDLSQQEYVIKIEQLNHELVQAWNQDQRVKALKIAIQCSKLLSDTSVIQFYPSKFVLITDILDIFGRLVYDRLRTKAEYVHPGTREMTALPENFTPEMVPESAKETCQNWFYKIASIRELLPRLYVEIAILRCYSFLAKDEFSQALRRLSKMIRGIGDPLVAIYARCYLCRVGMGLTLDRTYIRENLDDVLMVYHTIFNGGIRSEIARHRITLSGYISLYLPALDWILQGVAIMTTDGQLDAILQRCTEKKNPALLMQSIMQSFRSDFIASRAAQLVQILSSISVEGLSRGQLLRLLGSIISHTPPPVDQRATVLASAWTTISALGNVEEYIQCAEMWAQYTSQHFGLKEIDSFMGDILQHMSPNRIYEQHYHELQVIVDKIVSNANDINGILALDNFLPLLDLFQKESIKLEVCKNILTSYRNASVSDTIIINDPVVTNTLMYISRVLNDSVNALTGEDERRQISSLICHFIRKVDFGRDFEQQLAFYVEARSVLSNLDSALSTLIHSVNRLATSTRRIIKGQHTPKTAAFVKACAAYCFITIPSIIDVRTRMELYLQSGQVALLNVCLQQADSCFEAALNLIPEVPRTVQIDGKMQSSESFLKSYVINFLSTLVIVPDNPTQGVLYLLRLLLDVVPKYSFEPGSNTLSSIYLHVLDFLSVAAQEVYPYHIVNVISNDELYGSDPKFIAEVNELCCDVCDKLLQQLKQLLDSNALRAQSQLALDLFVKIITGADLTVEKMFTLTYNLWNLAVKNRNVLEPHQLQNVLSYTEHLATVTKVETQHQCLLILLEKMKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W102</accession>
    <name>A0A084W102_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011766</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W102"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011766-RA">
        <property type="protein sequence ID" value="ASIC011766-PA"/>
        <property type="gene ID" value="ASIC011766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011766"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011766-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="17344" checksum="61E90EFEA9B4AEE7" modified="2014-10-29" version="1">MSFVLNFSWTRGKKGTRTGTVTEHSARSQALLPTRKRKRFLTSRTTVATARYTTSLHLLRRRNKRCGGLPSGFNLPAGLEFHPPPLQPTVRTLRRSHTLTDSPRTFPAYAPVELTRSRSSTDVTNNNNNNSNRYDRDRVRVDEFRLGDTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W196</accession>
    <name>A0A084W196_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W196"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011818-RA">
        <property type="protein sequence ID" value="ASIC011818-PA"/>
        <property type="gene ID" value="ASIC011818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011818"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015116"/>
    <dbReference type="OMA" id="NASEPCI"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF22">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="336" mass="38741" checksum="C2D7FD7EF9E63CC4" modified="2014-10-29" version="1">MIQFFFALGGMVFGLSCLNHFESNTPFRGLYFVEKLVRRLIRILPVYGFVIFYHATWYKRVKRGPLEFKFYDYCSEHWWTNVLFINNYVLPTKPCLQYGWYLGADLHLFLISSLLLMLVWRFPRTKQTVAAIMAFVALAVPAFVIYTNSTAATMTFDMRHALAELRTYEHFIKYYLPSHTNVSGYFFGVIAAMTYKGVVAGEYQHRVQTVLQRAFATCTIALVGLNAFTMVLPSLDSNPNWSIFLAVYGSLLKGSWGLSYGVLFLVLGLKRKSLLVDFLSHPLMHCLAKLSYCIYIAQYSVIYGVYTNFPIPLMYGTFNLPLFYSRSSALFCFTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1E2</accession>
    <name>A0A084W1E2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011866</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525267">
        <property type="protein sequence ID" value="KFB44036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011866-RA">
        <property type="protein sequence ID" value="ASIC011866-PA"/>
        <property type="gene ID" value="ASIC011866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011866"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12532" checksum="CFB512C0A1B90E35" modified="2014-10-29" version="1">MNQFLTPNIVHQTPTEVEAWRLKESLGTASVLERAQLWHPCHPRCLQLDLGKREGEWKLALEFRNRAPAIRTPCGIERWQNQQTGVIFVIGFESIYYLAFEGAQPQGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1R3</accession>
    <name>A0A084W1R3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">omega-amidase</fullName>
            <ecNumber evidence="4">3.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nitrilase homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011995</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:32963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16769"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:32964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-oxosuccinamate + H2O = oxaloacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57735"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59413"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.3" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01019415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1R3"/>
    <dbReference type="STRING" id="74873.A0A084W1R3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011995-RA">
        <property type="protein sequence ID" value="ASIC011995-PA"/>
        <property type="gene ID" value="ASIC011995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011995"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022670"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="30968" checksum="FD92005C0A27601D" modified="2014-10-29" version="1">MSAVRAGFRIALVQLKVGANKTQNIENALTKIRSAVTDKGARVVALPECFNSPYGTQHFPEYAEEIPAGETSRSLAAIAKELGIYLIGGTIPEKCRTDSKLYNTCTVWSPEGSLLATYRKIHLFDINIPGGITFRESDVLTGGSELATVAIDGAKIGLGICYDIRFDELARLYRNQGCDMLIYPGAFNMKTGPLHWELLARGRANDTQSYVATISPARDQSAGYVAWGHSMVVDPWAKVVSQAAEAEETVVADVNLQTVDEVRAQIPIFSQRRTDMYSTDAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W294</accession>
    <name>A0A084W294_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012276</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W294"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012276-RA">
        <property type="protein sequence ID" value="ASIC012276-PA"/>
        <property type="gene ID" value="ASIC012276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012276"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012276-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="18896" checksum="40B1FC699EEAF2F4" modified="2014-10-29" version="1">MAPGTCGFGEWRGGGGRVRVAAREKQDGQWKKPGTHFATTIISMKYRLANSSANRTATVRPVGVAWRAFSCRANERPILFGIWKGYVHPLSPMVGGCGGSGAATLGKRGQRAHVDMISIFKCHNSYTNGQTAHDTHLSLVRKGKKDPCRAGEIALAATNPPTFAARLTSGRCYGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2G9</accession>
    <name>A0A084W2G9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="10">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="10">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="10">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012195</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="10"/>
    <dbReference type="EC" id="2.7.7.50" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01019619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2G9"/>
    <dbReference type="STRING" id="74873.A0A084W2G9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012195-RA">
        <property type="protein sequence ID" value="ASIC012195-PA"/>
        <property type="gene ID" value="ASIC012195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012195"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004830"/>
    <dbReference type="OMA" id="FWDIWMS"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000291">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.87.10">
        <property type="entry name" value="mRNA Capping Enzyme, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="485"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="556"/>
            <end position="561"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="608" mass="70180" checksum="036BB13FDEF95FB7" modified="2014-10-29" version="1">MSRGPGPIPHRWLHCPRKSDTLIAGRFLAFKTPLKQEFESQIPIECKFTPSMLVDLMRRHKVRIGLWIDLTNTNRFYDKHEIEDKGSQYIKLQCRGHGETPSREQAKAFIEIVEEFIENHPVEAVGVHCTHGFNRTGFLIVSYMVEKMDCAVDAALMAFAQARPPGIYKADYIRELFRRYGDEEDAPMPPELPAWCLEYDDGDGQQQQEDDAVEEQNDSARRGKKRTREEGENSGNGGEASLPTKRSKGGPSYNPNAVFMEGVPNVTLLQDKALIAKLQDRVRMMCGSKMQGFSGAQPVSMDMGNLRFLTQMPYRVSWKADGTRYMMLIHREKEIYFFDRDNSVFAVEGIRFPSLEDPNRHLADTLVDGEMVIDKYGDQLTPRYLVYDVIYFQNREVRTLPFHPDRLTLIDRELIASRTRAIQKGLIDRSIEPFGVRLKQFWDIKQSEALLGPKFTKTLGHEPDGLIYQPSIDPYTPGVCKRVLKWKPHHMNSIDFRLVIQEERKLGMVPRKIGLLYVGGMEQSYGEIKLTKELRKLNNKIIECKYQEGLGWVLMRERTDKSFPNSYETARSVWESIRRPVTMEILLTLIKNEGYRSDSERMPPPNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2K7</accession>
    <name>A0A084W2K7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012237</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019626">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2K7"/>
    <dbReference type="STRING" id="74873.A0A084W2K7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012237-RA">
        <property type="protein sequence ID" value="ASIC012237-PA"/>
        <property type="gene ID" value="ASIC012237"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012237"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011548"/>
    <dbReference type="OMA" id="ERETTHH"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012237-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="470" mass="49540" checksum="81AF86952A2C94D8" modified="2014-10-29" version="1">MPLPTSDFHTTVCLEMRMMKNSMNSNCVVPPMQFGPSTISYPYPYMDTPIKHANTGNTGSPAGAAAAMAGVDSSDTYASCQTHPFLSQADLTSDIVDMSFDLDTLDTNNLPGAPLGAPPAVRSQVKKSASGDTALRSLGASPMDDEYRQFQTAFDAADRGSHVSLNETPVPKHRKTRFQQSAASAALVAAAARPKTRFENLKSSLESLEDSSAAAASASAAVPGSSNGTKKSRRSSFMPAKSLASATKLINQHLFGIPNPAPKDSIETSPQLETHRRSKSILKNKSEASRLLSDPESERLLADNMSGSGVSDNGANMGSDSNTDYSGSTMIATSITPLVQRHRLTHQRSTPASLGATAKLPASKFSQPRYSQEEVARQAKPQLTRGVGIGTYVDHLTGDRRLDTGTRESSTESETAFSTYLAASNSNSNKDKASFAGSSLTSSDESKTTTSRGNSVENHGGSSGYGASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2V0</accession>
    <name>A0A084W2V0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012423</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019701">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2V0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012423-RA">
        <property type="protein sequence ID" value="ASIC012423-PA"/>
        <property type="gene ID" value="ASIC012423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012423"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16621" checksum="8826CC59ECE040D5" modified="2014-10-29" version="1">MSLHLAAITDAGTDAAPDKDNGRLCCPLPCSEARKPKSEVSRNVCFGSSLLLSVGAQSKPNEWNIRSKKGCACVCMWPLYVATMGDCFEFTTSKHGLGGELRFRWHVSAARLRQLYASRKHASFRFSVTNTLTVVGSLGSRVTGQRQCQAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W329</accession>
    <name>A0A084W329_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012507</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019797">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W329"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012507-RA">
        <property type="protein sequence ID" value="ASIC012507-PA"/>
        <property type="gene ID" value="ASIC012507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012507"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012507-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7414" checksum="697E4F77B866970F" modified="2014-10-29" version="1">MPSSAAISSFLQFPPGGSRRDTRQSVGSRANTDLADDDLRLPEVISGCRTVEVPDATHSARVRRLEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3H2</accession>
    <name>A0A084W3H2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001362-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012668</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525289">
        <property type="protein sequence ID" value="KFB44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3H2"/>
    <dbReference type="STRING" id="74873.A0A084W3H2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012668-RA">
        <property type="protein sequence ID" value="ASIC012668-PA"/>
        <property type="gene ID" value="ASIC012668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012668"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022832"/>
    <dbReference type="OMA" id="IWKEYND"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000990">
        <property type="entry name" value="GG12984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001116">
        <property type="entry name" value="GM10830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000085">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="910" mass="102049" checksum="97B4E3F2AEDC2163" modified="2014-10-29" version="1">MEFSQPPPSVDAPVQHFANPPPINRILSYQNPQPPKQQFNFYHHKPYHHFNGFRGGGPMSQDDFDGKRLRKSVMRKTVDYNAAIIKALEYRTWQRDHRDRRALQPESIYIPELLPPPSYMDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRLITGASSGEFTLWNGLMFNFETILQAHDVSVRTMVWSHNDNWMVTGDHGGFVKYWQSNMNNVKMFQAHKDPIRGISFSPSDAKFASCSDDGTVRVWDFLRCQEERVLRGHGADVKCVHWHPQKALIVSGSKDNQQPIKLWDPKCGQALATLHAHKSTVMDLKWNDNGNWLVTASRDHLLKLFDLRNLSEEVQVFRGHKREASAVSWHPVHEGLFASGGSDGSILFWNVGTNKEVGSIDIAHDSIVWTLAWHPLGHILCSGSNDHTVKFWTRNRPGDQMRDKYNLNTLPASLAGLDECELEEHIVIPGMGPEDKVDIVESIATKETGPIPGLDLNVNNFNDKLRDKKIPYSKPIPRKFQAQWNELKPDEQTAAEEIKEVISQIVDGGPSAPKKPAPTAISLYERTIAVIPGSPLEEAIEAGTEALTRFIERGGIKELHHLFPPLPADGDPASNGDPSKPPAKRFRLDVEPKFFYGPQPFMMDPQLSMPSRDSEQSRDSAASNEDAASKGDAFDPKLPSLLQLDINPPPNVQFTTDEHADEVVLRGTWKGREREKQREREKRDLEQDKKIWKEYNDRNWDEDEDETMGDSSNRPDSPASQNTNSNGPWGAAFENEMPPGPPQGISWQTDKGGGPSMPPGGPPPFGVGYGDDDGAPSLDGFNCQRPPPPIGVGQPPPFMNQPHHPSAFAMMGGRNDDDGGFHNNIHNPGDHRGEFNRNDDWGRNDGGMHRGGGHRGGNRGGGRDFRDGRWERGFRGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3J0</accession>
    <name>A0A084W3J0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01020054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3J0"/>
    <dbReference type="STRING" id="74873.A0A084W3J0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012754-RA">
        <property type="protein sequence ID" value="ASIC012754-PA"/>
        <property type="gene ID" value="ASIC012754"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012754"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015996"/>
    <dbReference type="OMA" id="WESFPHL"/>
    <dbReference type="OrthoDB" id="8048957at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012754-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="338" mass="37540" checksum="6ED9EA80DCCB286F" modified="2014-10-29" version="1">MDSILSKLCIGLLIVVVLAIIFICVAFVISYENEEQLVATIELHTVDLPPEQSVWFETNLAELRNAFRVPKNNRRAKNVALFVALGRVESSGAQQSPIWESFPHLALLRASQDRWPKLNPTALFCGIETRPGTIGLDSGVEPAGECIDVEHNVHQTHEVESIVQWAQAVGRRTALVTNGEIVMPFPAALYAHTPNEGWMFTSPEPTRCPSVQTQLLRSATGKELNVIAGSFDCLTPACEDNFVSAWEKQKMLDDVSYRVSADMNDLLNSEDESEYVLGLYNRSELEKPGAFQNLTLGALHSVHKSEGFLLVAIADSMKDISLQELDATVRSTLWKLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3U0</accession>
    <name>A0A084W3U0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012794</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020140">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3U0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012794-RA">
        <property type="protein sequence ID" value="ASIC012794-PA"/>
        <property type="gene ID" value="ASIC012794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012794"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17421" checksum="6F6505328404A5D0" modified="2014-10-29" version="1">MRKHLHGALFVRNQPSLEYPSLASEARWKLHNVRAAGERVPGKELPAWPHRTTESVAGASVERFRSRLDSKPRRPLTLESPGYGDGGMTSASSVRPVWSHGTRRTSSQREANESENETIASHVTEACERRKQKESETNSLTGDVTEGKETVNYGKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3X1</accession>
    <name>A0A084W3X1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00012828</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3X1"/>
    <dbReference type="STRING" id="74873.A0A084W3X1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012828-RA">
        <property type="protein sequence ID" value="ASIC012828-PA"/>
        <property type="gene ID" value="ASIC012828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022798"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="363"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="693" mass="78836" checksum="3A15BA1DB38F1327" modified="2014-10-29" version="1">MPIATQYCHVVIVRIFLPPQSSRVNISRLNYTENPEDFCLDTIRQTITIEGLTVDDAGTYKCAVVDHVNGFNSADFKLYVLDLKGINHRSNRTTRDVESDEFVFFDTANNPTTVNVSHSSDRPVRMVLGYESYPSLTSVEWYKDGRRLNIAQDHRYQATETDTELQLVISNLSLYDIGRYTVIARTDTAQDSYNVSVFIYDKPTLKMGSINTTVGKMVEFVCESHAFPQPEFDIGFLPCHSLEWRTCMENRSQYKNMKSEESIISIIEVHHTMKFQANVSGIVLCDAANDYGKAEAEGYLIVVHSSLQFAVEGVIISLFVVLTVVVVIVVRRLRRFVRYRKPPIVEDEELIISEQYEFPRERLRLGSLIGSGQFGVVLQAVADGIVTEGEETTVAVKLVRDVNERNVISVLIAELKVMIHIGHHLNVVNLLGAVTQNVPKNEMMMIVEHCKYGNVSDFLITNRTNFVDELDPVTGQYTSTRNFENLDLNDTLVGCTFRTSHLCSWATQIARGMSFLTARSVLHGDLAARNVLLCPDNVVKICDFGLARTLYRTNVYKKTSPDPLPLKWLALECISDRTFSTHSDVWAYGIVLWELFSLGSVPYPEQGNDAELVNALRQGYRMKKPSAANFEMYNIMLNCWRQEPTGRPSFEQLYQWFYNFLPQNIQMHHDQQLLTIDNNDGKVTILTDSCKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4X1</accession>
    <name>A0A084W4X1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Trehalose 6-phosphate synthase family member (Tps-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013190</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4X1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013190-RA">
        <property type="protein sequence ID" value="ASIC013190-PA"/>
        <property type="gene ID" value="ASIC013190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013190"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8480" checksum="7DA9F33A23E4328A" modified="2014-10-29" version="1">MTRTVVQTIRRDGTPTALSVDAPSPNPPDTVRGHLHRAGQGVCRKWRRDDDYLSATVMSMMIVEGFGECLQFVTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5B3</accession>
    <name>A0A084W5B3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013337</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5B3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013337-RA">
        <property type="protein sequence ID" value="ASIC013337-PA"/>
        <property type="gene ID" value="ASIC013337"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013337"/>
    <dbReference type="OMA" id="PYQSHYQ"/>
    <dbReference type="OrthoDB" id="7746285at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013337-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="453" mass="46585" checksum="5A08877972578E51" modified="2014-10-29" version="1">MVTTIKITGDGVFIQSNSFNGGIGGPGGGGRLQQQQQQQQLTEAALGSPALGEPALPGSARNGNGSLDTVDSAGVSAASLLSDTNNNHKGYRNFNHRRYQSDEGPGFIGVGLKNGLPEEGSSDCTEVPVGAEADDTIGPDSGRKRDKFTISFLNTHRSPGGSPHGGKSLLNHKFIVYNSKKPKTSSVLHQQFYQQQADTGSSRGGSPPSPSPYQSHYQQYLYNRLRPSLSTSVLSSPSLLGGTVGAGPNLSRADQQHLLQQQQQHQQVQRDRDQQHLYQNSLFHQQHRALLGTPPAAVPGWAKSTSCLVTSSSAGSSAYNRSITGSPLLLLTQSSRSTPPQPTSIGTNSAPGIGPNSSSISSLSSPSTSSGSSAGGSSTPASGASSSSNSPPPPEDRASPTSPTPPTNGAAVPTSSSSTSPARQVSPLTPAAPSTPTQSPPSPTSPAPANLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6F9</accession>
    <name>A0A084W6F9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006829-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013781</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020792">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6F9"/>
    <dbReference type="STRING" id="74873.A0A084W6F9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013781-RA">
        <property type="protein sequence ID" value="ASIC013781-PA"/>
        <property type="gene ID" value="ASIC013781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013781"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002955"/>
    <dbReference type="OMA" id="HAHVSHY"/>
    <dbReference type="OrthoDB" id="7789829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF80">
        <property type="entry name" value="CUTICULAR PROTEIN 62BC, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784542" evidence="3">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="21286" checksum="F7706A1B800FC968" modified="2014-10-29" version="1">MAFIKSFVCLAVLGVAAAGLVPLAQEYSHDGDYYAHPKYSYNYGVHDSLTGDVKSQVESRDGDVVKGQYSLVEPDGSVRTVDYTADDVNGFNAVVSKSAPSVHAKTVVAHAAPAVVAHAAPAVYASHAAPAVYASHAAPAVYASHAAPAVYASHAAPATVLKTVVSAPAQAVYASHAAPVYASHAYAPAHGTVEYHGKAAAPLAYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6P9</accession>
    <name>A0A084W6P9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Solute carrier family 22 member 8 isoform 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013856</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6P9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013856-RA">
        <property type="protein sequence ID" value="ASIC013856-PA"/>
        <property type="gene ID" value="ASIC013856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013856"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="12035" checksum="9D07E0D434581657" modified="2014-10-29" version="1">MNQPASPQWASDILSYFLPTPHPPRQTFPPPAHRFGPGDILSDAVKLMQPESHRLIRNTVTVIGIAIARFAPFSPHVKRRETYRRRSSRWQWSTKSLNSGFGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W988</accession>
    <name>A0A084W988_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP010996-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014786</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W988"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014786-RA">
        <property type="protein sequence ID" value="ASIC014786-PA"/>
        <property type="gene ID" value="ASIC014786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006421"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022972"/>
    <dbReference type="OrthoDB" id="7739148at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="252" mass="29561" checksum="29AB7E5D1415864B" modified="2014-10-29" version="1">MDKVLYNKKIDFCAFLQRPNERIIKMIYDEVKTHATPPFPSACPLREMQTLHVLYTVRRGTVNNVLYNRKIDFCTFLKRPTERIIKMIYDDFKRQTRAALPTSCPIQPRRILFTNISLNNVKLPAFLPQTDFEFQINIGLWLDVASGVLRTPLYNRTVDFCNFLRNPGVHRLGQIVHREMKNRGNMPTRCPIPPNLYQFRGVSLSHMRMPPFFVETDFVLDVNVGVENDRCFHSRWFGAIKKIKCSKSERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H7</accession>
    <name>A0A084W9H7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin maturation protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin aminopeptidase ACTMAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014897</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + N-acetyl-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:74579"/>
            <dbReference type="Rhea" id="RHEA-COMP:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:18395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64720"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
            <dbReference type="ChEBI" id="CHEBI:193599"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:74580"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ACTMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525323">
        <property type="protein sequence ID" value="KFB46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9H7"/>
    <dbReference type="STRING" id="74873.A0A084W9H7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014897-RA">
        <property type="protein sequence ID" value="ASIC014897-PA"/>
        <property type="gene ID" value="ASIC014897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014897"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001656"/>
    <dbReference type="OMA" id="CFLNRVC"/>
    <dbReference type="OrthoDB" id="198816at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040043">
        <property type="entry name" value="ACTMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631:SF1">
        <property type="entry name" value="ACTIN MATURATION PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631">
        <property type="entry name" value="UPF0692 PROTEIN C19ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="291" mass="32469" checksum="7A0D8E9A5BF31A17" modified="2014-10-29" version="1">MSNSPTTPPPPPPPPTGTPCQQQSKTPLTERNVVDVINNNGNRIGKPHHNVILSSGECAWATQYPEIQKACFLNRVCQYAPPRELRVQNVEPILQNGPTCGLTALSMIFDGAPSAKALLEQAIARGYSNNGEMFSARQLNELFEVVLEENRHLVEYKPVTHTLISGWMDDPNIQIKLRLGAMFLVPYDPDKNHTPCLNRGHRAHWALVVGYLIDQFEDFYVFARHGKTKNLALWSLRDLAKSNANLVEFCQPVGHPNETFILPEGGMGGCNGLLCKFIMIENYKAKNEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9W8</accession>
    <name>A0A084W9W8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015026</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9W8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015026-RA">
        <property type="protein sequence ID" value="ASIC015026-PA"/>
        <property type="gene ID" value="ASIC015026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015026"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="11276" checksum="F08A6A8B9EE48271" modified="2014-10-29" version="1">MRVTFSQTFVRGKLCPSPRGAFFNMEQQFHKHTGVRRLSQPYSFVCLRTATRRQSARSLLESHLDVYMLLSDQRFALPRQSVSTPTRWSTGLAGPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAW7</accession>
    <name>A0A084WAW7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Alpha-toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015603</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015603-RA">
        <property type="protein sequence ID" value="ASIC015603-PA"/>
        <property type="gene ID" value="ASIC015603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015603"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7227" checksum="9F83CE2F988E9E75" modified="2014-10-29" version="1">MISIINPPPAIDSVSVLEAGEHLELLQRRGQNWALEAKTTGFGWCVATSCQSIGQLPGVDCCECLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAY4</accession>
    <name>A0A084WAY4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015623</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015623-RA">
        <property type="protein sequence ID" value="ASIC015623-PA"/>
        <property type="gene ID" value="ASIC015623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015623"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5669" checksum="5E3E313D4A55F63A" modified="2014-10-29" version="1">MLLVIAQACSIPLTPGLLFVSVPVEGLFFLPMVPLGPEIYYQTSDVPGGCRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCX5</accession>
    <name>A0A084WCX5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6-interacting golgin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016039</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GORAB family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016039-RA">
        <property type="protein sequence ID" value="ASIC016039-PA"/>
        <property type="gene ID" value="ASIC016039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016039"/>
    <dbReference type="OMA" id="MMHAPED"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007033">
        <property type="entry name" value="GORAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470:SF2">
        <property type="entry name" value="RAB6-INTERACTING GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21470">
        <property type="entry name" value="RAB6-INTERACTING PROTEIN GORAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="299" mass="32863" checksum="77AA910D540EB856" modified="2014-10-29" version="1">MSKQFVGFSDDDIFKISRQTNGKDSAKDPPRPHKLPKAPPGAVKFVPPPATLDTGAVSYVDSSIYPNHQIQQAVAFKPLPVMMNAPEDESILVLPGQQVGNQVTAPTAAIATSTPGVAGLRPVLAEAVTPFKGMSLKDFEHQRRLMEEQNRQKREILHKAIEQHAQKTAAEASKIQEIKSELTKLDSELASDVAILRKQIDAASLHFSNVEKNYLNIENMFLKAKVELHQALEKKEMLTEHLCAIISHNEERKAQRLSELMERVGISVTGESDDTLNGNSSYAPDTTSAPAEPDTPTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDD3</accession>
    <name>A0A084WDD3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Beta-glucanase/Beta-glucan synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016347</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022991">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016347-RA">
        <property type="protein sequence ID" value="ASIC016347-PA"/>
        <property type="gene ID" value="ASIC016347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016347"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016347-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8216" checksum="384D9CBA79DE7126" modified="2014-10-29" version="1">MVRGNAISKQKGRTIASNVLHAAIASPLVDPVISPNPFAMLANAPMDQLDGPEINGKIAVSGMPTTTVKRTERIPPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDJ5</accession>
    <name>A0A084WDJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP005795-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016266</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WDJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016266-RA">
        <property type="protein sequence ID" value="ASIC016266-PA"/>
        <property type="gene ID" value="ASIC016266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016266"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016147"/>
    <dbReference type="OMA" id="ESCAKSM"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF39">
        <property type="entry name" value="GH10366P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784708" evidence="14">
        <location>
            <begin position="27"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="656"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="711"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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            <dbReference type="EMBL" id="KFB48289.1"/>
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    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="789" mass="84693" checksum="F2C55004507DE517" modified="2014-10-29" version="1">MAIGGRMYLVAVVLIALTSAFQPAVAQEETDDETSRSFTAYDYVAVGAMLVISIGIGVFYGWFEKKGSSGSAEDGGATAGASSDDFLLGSGMSLFPVTLSLTTSFITAIELLGNPSEMFFNGTQFSLIVISMVLVVPVAVKVFYPIYYKLEVTSCYEYLGMRFDKRIRVFGAVLYILQMLFYTSVAVLAPAIALSEATGLNRYIAVVLIYFVCIFYSSQGGMKAVVIADTFQACVLLLSLILILALGSHYSAGLPDVFSRASEHDRIEFFNFDPNPTTRHTVFSVIIGGFFYWTSLFCTNQASVQKCMSLKSLKTAKRALYFSLLGLIAVFLMNFYTGLMTFAHYSDCDPLAAGQITAKDQLLPYYVMDVFGHIKFMTGIFVAGIFAASLGTVAAALNSLAAVTSEDLLVTGMQVKIPEGKGALYAKWMSLGFGLVSFGLVFVVERLGGILQATLTLNGLIGGVTLGLFSLGIFFRRANSKGAMFGGITALVLVIVVGVLAQLNNEDPVPLPTSVEGCSAGGSSWDNRQSLGYEVHPMGESVSLALKLNAGADQHGAVESLLKIVGHGDWSGRDSEQHFYRLSSEESPVQSTTDYGEDVKALARQNGDTDDDSSWFAAVYGISYMWYSCLGTLLTLLFGIIISLATSDEPLGCCSSRNSSSLQSELPTTVVPNSVSSKDAMESPDKKRSKLSVGSMAPLAMMMRTSVTLSPCASPRRLQPKESPSNGASVDSSMASVFSVDQQTISSELGSYTEEDRREDVRRAATGLSSAPGSTFPSTVSMKVESERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDT9</accession>
    <name>A0A084WDT9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Arachidonate 5-lipoxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016505</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016505-RA">
        <property type="protein sequence ID" value="ASIC016505-PA"/>
        <property type="gene ID" value="ASIC016505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016505"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016505-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7436" checksum="998FAEC679E07DAF" modified="2014-10-29" version="1">MTNFATGQKIHAAFVNNELLGASSGCGLPACPSEGWLSVSVGKLTTTTTTTTTMAKFGLRWRLTTSRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WES0</accession>
    <name>A0A084WES0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007214-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00016716</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WES0"/>
    <dbReference type="STRING" id="74873.A0A084WES0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016716-RA">
        <property type="protein sequence ID" value="ASIC016716-PA"/>
        <property type="gene ID" value="ASIC016716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016716"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002504"/>
    <dbReference type="OMA" id="EYEQCKP"/>
    <dbReference type="OrthoDB" id="538817at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="5">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="454" mass="53112" checksum="E5CD5AC9E6DBBDC3" modified="2014-10-29" version="1">MFWGFCEALDLVEEYKKILPKDTPLPDTLDILLFGSGDPRHILATAATLWRNPQVKVNFYIVEGCIELIARHMLLVAIALEDPEHLSIRGKTHLFMDLFGNSLIRPYSTAYLNSKAKVLTNIVTDPEYAERYSPIFNYEALKYKERDQLEDVFRFWTNAREHVFNISRYWEDRTRTQLGVRYDHRNGAFDWDLQMRLRENGAKQICPQEYKHWRETGIAFTFPEYEQSDPNKTFAVGLVRKGKTFHHRGSVGDNSTGPFISFGQRCPEERLTRSKHGVNDFRSTDITERNIMQIMYEIKERQAYQFDPKDIHQYGPHKLDTGKNLNKHEARSEVLEAARYDGPMIGCENLKIFFLSVEDVLRVQVDVKYAGKFDAVFVASNYFRLLKPGFRANWKPDCLLCFETRQLTTFSKDEIAEHNEAIKTFAKHEVLQPVTNFAINKNYSVHFYKQVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG84</accession>
    <name>A0A084WG84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Vacuolar protein sorting 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017233</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023462">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023463">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC017233-RA">
        <property type="protein sequence ID" value="ASIC017233-PA"/>
        <property type="gene ID" value="ASIC017233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017233"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023489"/>
    <dbReference type="OMA" id="IEFVMDQ"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14306">
        <property type="entry name" value="UBA_VP13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="2648"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="domain" description="MH1" evidence="6">
        <location>
            <begin position="4441"/>
            <end position="4509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1166"/>
        </location>
    </feature>
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        <location>
            <begin position="1248"/>
            <end position="1273"/>
        </location>
    </feature>
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        <location>
            <begin position="1846"/>
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        </location>
    </feature>
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        <location>
            <begin position="2616"/>
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        </location>
    </feature>
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        <location>
            <begin position="3815"/>
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        </location>
    </feature>
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        <location>
            <begin position="4258"/>
            <end position="4280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
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        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
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        </location>
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            <begin position="2628"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3835"/>
            <end position="3845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="4509" mass="499893" checksum="3F87E926B3C20E02" modified="2014-10-29" version="1">[encoded data, 4509 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGB1</accession>
    <name>A0A084WGB1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC017365-PA"/>
        <property type="gene ID" value="ASIC017365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017365"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018740"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784991" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6824" checksum="70518C89E3C9EFC0" modified="2014-10-29" version="1">MRGVLLQMTLCLVLLEMPNVWGKLASYKGIVPPAKLGRSDEMAKYAVVNYDDYPVRRHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHD2</accession>
    <name>A0A084WHD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007734-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023802">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHD2"/>
    <dbReference type="STRING" id="74873.A0A084WHD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017642-RA">
        <property type="protein sequence ID" value="ASIC017642-PA"/>
        <property type="gene ID" value="ASIC017642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017642"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013742"/>
    <dbReference type="OMA" id="EQRTHNY"/>
    <dbReference type="OrthoDB" id="5832575at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039139">
        <property type="entry name" value="CCDC170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863">
        <property type="entry name" value="TSEC-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="774" mass="88734" checksum="3DE859BF00E9C20A" modified="2014-10-29" version="1">MPKHHTPHSPVHHHHHAFINVSYVSLQPPPSCNDHLAHSIDLATTLRSELAASTYKRDRLMAELSDVKSSLCAKESECESLRAQSARQTSLISSLQQRLAATEQREKALHSRSETVVHTLNRDKNHLEEKIKELGGKIHRLQCELTKEEGLRDQARCQLQDLIRRLCLVLGIDVCDGTHLTPDCVLSKTGETVSEVQRLRAKLAGTCENLSSTEAELINTKTTASAEKTRLHSQIEGLQSLSQGLEGRCRQAERDLQVTRDRLAECEVNGDKLREELRGFESRCCRLQNSYDRLQTERLQFLRTIATIVGVSEPCENNIRDKIRDLTNHNQALHDQVAQLRDQHHQEVAKHREHQESSACRLKSEEQHRMNLEERLEKACHELQHFRAEHTTLSDYLLRLARALCWSECTEPPAPGSDTTILSETLLERAERLATHHEHHLHGSCDKSCWESINHHHHHAHTHSHSASKLRRERSCTDLPLKESSTLYHMQRKVRVLKEQIQRRDLHLELLRRKIALLEDNARGKATLQTERDEAMHKARKNSKQAERTTHQLAEVKSQLAEVKMQLNEASEYKITALERARKCDELQSRLCELETERERLVGQLAAYKSRARSAVETSHDRRVRDEHAMTHLRDELSRIKSQLADTNHRLSQLQVFRSSVAKLLHVSDCSDSEILQKLQSVCSNHSHHHHHRHSHSASNLSRRYDSSSPLAGDLHTTSRYDDFTTGAGGGGGSQSLACRPLSSSPVHNRRYIDSGFNDHDHHYDDEFDYHKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHG5</accession>
    <name>A0A084WHG5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHG5"/>
    <dbReference type="STRING" id="74873.A0A084WHG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018384-RA">
        <property type="protein sequence ID" value="ASIC018384-PA"/>
        <property type="gene ID" value="ASIC018384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018384"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009790"/>
    <dbReference type="OMA" id="EDNYEAR"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000028">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="9">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17515" checksum="48286F304548EDA2" modified="2014-10-29" version="1">MGKIKTEKADVSDAAANESLVKDEDDYEEKLRNASAIAHPMASKKLTKKIHKLIEKASKQKTFLRNGLKDVQVRLRKGETGLVVFAGDVTPVEIMCHLPAVCEEKNIPYCYTPSRKDLGSAMGVKRGTVAMLIREHPDYKDMYDKLKVELSTLPVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHP2</accession>
    <name>A0A084WHP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018390</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018390-RA">
        <property type="protein sequence ID" value="ASIC018390-PA"/>
        <property type="gene ID" value="ASIC018390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10242" checksum="5BA76D4E323C474A" modified="2014-10-29" version="1">MFASSESKSPSPRSVVSLLHQTHLRMDQSPVWKVWEGELLITIQLTARPNDKGSFETRIPPSCAKKDSGVGEVPKGRPLSLVVSYGAIELGPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIG5</accession>
    <name>A0A084WIG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP011943-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018051</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIG5"/>
    <dbReference type="STRING" id="74873.A0A084WIG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018051-RA">
        <property type="protein sequence ID" value="ASIC018051-PA"/>
        <property type="gene ID" value="ASIC018051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018051"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016146"/>
    <dbReference type="OMA" id="YLQDAHT"/>
    <dbReference type="OrthoDB" id="6506757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018051-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="676" mass="76998" checksum="8BB85D209A3AB041" modified="2014-10-29" version="1">MKNERGPTAAQAGVQCLELLSHTYFHMSESIQIENIVIFYLRNLSSPAREILLGYLQDHHTGYDEEPEDGEDGHSMFQLKLMSDDTSLESARRAQFMDHKKIDYYVLVIDDYAGLRRAMMYVASTAAFNPRGKFIVLYNNPNDRDSDQRLANDVLQLMFIGHHSVNVLFAFAFDATGYSIYTGDPYHGTKDCGQMKPLKVATVVNGSFTNGALARAMINIPKVPPEMEACTFLLCTRVAPPFIDMDCQHGLELQIMDLLQQSMKFKVNVSCSEMDRGELLDDGNWTDLLGLMRADDCDIIAGGFNPDFDVHDEFGSTTPYLQDYHTWFVPMAGTDARWKLLVLIFDLKTWELFAFVLLISALAWRFVGQFLPEAAPHKQLAMCFLNTWCVFLCISSNNRPGCHALRIFFVALALYGLNVTTIYTSILFTILTDPPRAYQVDSIEEILASNIPIGGRLDSEDWFMNNFDDDRLVSERYNSSPDFQPSLDNLDAVVAGKRSLLMSRLYVRNTKYHGLVHGLSTDVFATQIEMIMEKGFPLLPKFNRILSNLIDMGLMEKLWNDFLYNVTILNHIKRNRQLSEEEIRAASPEVVLTLDHLQSAFALYAIGVALCLVIFLLELISKTAWIQQVLEKLDSRWDRTLIHLQLREQKSGKVKLRSRDLSRGKKAKKVTRKPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIK2</accession>
    <name>A0A084WIK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Rho guanine nucleotide exchange factor 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018094-RA">
        <property type="protein sequence ID" value="ASIC018094-PA"/>
        <property type="gene ID" value="ASIC018094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018094"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10462" checksum="794DFD3815BFFAF1" modified="2014-10-29" version="1">MAATKPRLLTGPIYSRETQMDESVAASRKVRGGWIIVAHQRPTPTTPGSMARPKVPGDPSVSWRSLHKFHKCAHNESFADRRRRQLGKGKVVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIZ6</accession>
    <name>A0A084WIZ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00018255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01023957">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIZ6"/>
    <dbReference type="STRING" id="74873.A0A084WIZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018255-RA">
        <property type="protein sequence ID" value="ASIC018255-PA"/>
        <property type="gene ID" value="ASIC018255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018255"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008818"/>
    <dbReference type="OMA" id="MENTGHW"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB50190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20528" checksum="A1256432C5B4EC8F" modified="2014-10-29" version="1">MSEGLTDKEAKELLKLPDAETKDFLFQQTMYRIKDPRASLPFYNEVLGMNLLCKLDFPEAKFSLYFMGFEDIANQPKDRKECMQWAMSRKATLELTHNWGTENDPEFKYHNGNSDPRGYGHIGIMVPDVKKACERFDRLGVEYVKRPDEGRMKGLAFIKDPDGYWIEIFSASTVQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJC5</accession>
    <name>A0A084WJC5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004879-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018586</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024011">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJC5"/>
    <dbReference type="STRING" id="74873.A0A084WJC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018586-RA">
        <property type="protein sequence ID" value="ASIC018586-PA"/>
        <property type="gene ID" value="ASIC018586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018586"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014506"/>
    <dbReference type="OMA" id="TMVVIYY"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF167">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="173"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="413" mass="45590" checksum="7FA8C0261824AB66" modified="2014-10-29" version="1">MAPSPACSISFDENHHGVFFAGQRLSGVVDIELPKQKKVKGVLLKITGLGCVKWTETHGTGTTVPFSGREDFLMHTMDLVRAESDDPIELPPGRQIYRFSILLPKTLPTSFEGDYGYIRYTVRVIFERPWKFDLTYKIAFTVVNQLNLNSVSPPLNVAVVQEHIKTFSCGPCRSAPLTINVMLPMTGYVPGQFILVTVDVSNQSGKCITEMKLKLRRQVKYRSKCPYEEEKSVYCTLAKYQCSGVDARGSAGYERRFLVPPEPPTRNDTIIRIGYFVEVTARVVGMACSPSVRVPVTIGTVPLKNLNQTQQRASIVEAHLTTASTISRKSMHGSVQSLKILHSFEKATGGKEVSIHDDDVPPTLGADSFVPRYPMFQFDADNKPISHGKPIATVHAPPARNASGNDNTTEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJL5</accession>
    <name>A0A084WJL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005750-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018436</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024038">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJL5"/>
    <dbReference type="STRING" id="74873.A0A084WJL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018436-RA">
        <property type="protein sequence ID" value="ASIC018436-PA"/>
        <property type="gene ID" value="ASIC018436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018436"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012402"/>
    <dbReference type="OMA" id="EERQRMF"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000144">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785038" evidence="4">
        <location>
            <begin position="27"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="499" mass="56541" checksum="7846BF77494AED10" modified="2014-10-29" version="1">MGQNGFLRFALAGLAVLSVCVELTHSVNILCIMTVPSPSHHIWNRVIMEELVSRGHNVTVVSQDGDKSRTNLTYIMLEKVYSTLYEEDGMDLIEISKETPLQALFTFKDFFLGMCRGALKSDGLNVILNYPDSFQFDLVLYDFGCGPCLLPLLHKFRYPPLVSLTAFGNPPYSIDVAGGHKQYAYAPHYALPFGVQMTFIERVDNTILHLLDAGFRKLYTMPQLDRMVRDHFGYADMPSLAEIEQRTVVMLLNTHPTIDSPEPLPPNVIPIGGSHIKEPAPLPSDLEEFMVSGKKGAVLFSLGSNVRSDMIGEERQRMFIEAFRQMPEYNFLWKFESDLKIPLPPNVIIRPWLPQNSILNHPNIKGFITHSGGLSTQEASWFGVPLIGMPFFVDQHRNMKRSLIAGVAEKLDFSSLSTRKIKETVLKVLETPSYRENMLLRSMYFRDQPDKPLDRAIWWIEFVARHPAPEHLRSPTLALGTTLSATRVSFVQNSLLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKE4</accession>
    <name>A0A084WKE4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006277-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKE4"/>
    <dbReference type="STRING" id="74873.A0A084WKE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018727-RA">
        <property type="protein sequence ID" value="ASIC018727-PA"/>
        <property type="gene ID" value="ASIC018727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018727"/>
    <dbReference type="OrthoDB" id="10031887at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018727-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7896" checksum="27228CC0BA4C40A7" modified="2014-10-29" version="1">MTKVRTLQSLFASVLRRTQNLSKDNKSILANTDWKKLWVESGQLGSSGGRIDNHLDSSDSTLIDDGETGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLM0</accession>
    <name>A0A084WLM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019173</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019173-RA">
        <property type="protein sequence ID" value="ASIC019173-PA"/>
        <property type="gene ID" value="ASIC019173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019173"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16219" checksum="2BBEA97488F4771F" modified="2014-10-29" version="1">MDICLLEAQFMSLDRLGFLGGKFFPTEATTNGNAGNRKRNQSVIAVSFLDGCCGHGSSFSDPPVARGLTCFQRCNHNSPVRHGTAERPNHRDTFVIARTAPVIIKLDKLRRVWHGTPSKHLPDKNGTVAAFSTAKLTRTGHSCRDTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLW2</accession>
    <name>A0A084WLW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019470</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019470-RA">
        <property type="protein sequence ID" value="ASIC019470-PA"/>
        <property type="gene ID" value="ASIC019470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019470"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="26799" checksum="AB8D4B1721EC9611" modified="2014-10-29" version="1">MQHAGVRWRKSQFQEESFKTALLFGRFASAAVTPKGQSTPDTEPEGRRARSADHLLLRGQLHQLRLRMRMEVLLRVSSAHSDAMLCEGCRWRTALKGSPGPGMAVTLVATASVMLSGTPTVASAREVEMTGPDDPPCHQMRRRRSPRQPPLGASPVPWSPGKVVKEPRAERPLWQQYERFHQQRVRRKFAPTIDRYLHQAVHVVLLVSTCRRRQLPSTAYPASKSQRAHITGLGTTPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMM4</accession>
    <name>A0A084WMM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101299090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024485">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019522-RA">
        <property type="protein sequence ID" value="ASIC019522-PA"/>
        <property type="gene ID" value="ASIC019522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019522"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21285" checksum="33F51739D53A616B" modified="2014-10-29" version="1">MPSSTSAFRHEEELFWTHSSAPTPCRGVSATLDGSQHRSSRREHLHSLDSLEGREKLPPSPTASNSTQLQVPPTDDGLPNAHRNGGRLPRKSLDAQEIRPLAHRPEWPGSVTSSLFSTKTKLKHSTQRRGLPRLKWSEEDVGLGEAKRGHFGHFDVSPRGVEPRRFQVSRFHGTCSKTHPAPFVVCFRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN04</accession>
    <name>A0A084WN04_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">FCH and double SH3 domains protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00019670</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN04"/>
    <dbReference type="STRING" id="74873.A0A084WN04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019670-RA">
        <property type="protein sequence ID" value="ASIC019670-PA"/>
        <property type="gene ID" value="ASIC019670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019670"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020639"/>
    <dbReference type="OMA" id="DECEENM"/>
    <dbReference type="OrthoDB" id="10065861at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051495">
        <property type="term" value="P:positive regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902905">
        <property type="term" value="P:positive regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11761">
        <property type="entry name" value="SH3_FCHSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000107">
        <property type="entry name" value="FCH and double SH3 domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000039">
        <property type="entry name" value="FCH and double SH3 domains protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000155">
        <property type="entry name" value="FCH and double SH3 domains protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035460">
        <property type="entry name" value="FCHSD_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="12">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="688"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
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        <location>
            <begin position="901"/>
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        </location>
    </feature>
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        <location>
            <begin position="915"/>
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    </feature>
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        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023329"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB51598.1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019670-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123300" checksum="905BEBA99192E326" modified="2014-10-29" version="1">MGKALHFSGSMPNLPLPPERTRRRQKLMNRYYYRQGNYTKFLKNLHTEQLAKLALKNQNECELLEDIRQFTLKRSAIEKSYSEALLKISSAYLNKKQACIPEIKMDGAEEKWNMWSVWQTVLEENEKLARARLAAVEVFQQQIADEAKVLRNTKLNSSKRCVENLSVVQKELQNSVSDVDKTKKIYFDEEHSAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKEQLEEKSTGARNDYILSLAAANAHQNRYFTIDLQTTMATMENYVYERVADYLALIGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLYYPVLKQHIQYEFEACDNDPVRKITADHESAAETLSREGKRWAGRVARESNVIRECARKLAVCTALREAGHRTDPNDQNGPDLETKIDEFRENIRKSEIAKAKAEARLECLRIGGINVDEWIQEAETLSVQEMPRSASSLSMRTDASGQGENPSSDSFYDSDNAEQDQPVSESSPAPKQPEPPLDEFVADSDEDEDFGVEQERQKIEQISHGWDDPTQVDWGAEEAAAAAASQAAEAAAQQQQQQQSQQAASQTFKCTALYSYTAQNPDELTIVESEQLEVVGEGDGDGWLRARNYRGEEGFVPHNYLDVERDTPVDTHTPAQLSTQISFSSVDYTVDNEDQDPMQDSGQSPDQISVISAPRKVNNQLYCVALYDYDATAEDELTFEEGQIIKLITKSPHGVDDGWWEGELMGKIGNFPSLVVEECDENGEPLTDAEDESPPPSAPPTFAAPAPPPPMILHEATPPEGESPKSANNGPAIDKFEFEMNTNQHEQYGTQFSAPPPARPPPGKCRAMDFHPQLSECGRKQSFISAEEAATMQEESRQEAAAAATASGAGSGGDSNQLNFAQIIVTAATPMHEEPDKKFPPADPVDTDDEEYEEPGAVGAEIVEKQEQETQELSSKQKSQDAQEPTKPASPPEEKPPAKSSAGRPEKPTGPPPKPAKPPSPPKPEKPATAPKPTNVAPKTQAKKPDRTRAAPDPEPEADLSSDEVAPVEDPIAPFGEPFGGEAGGFEANFEANFDANFDDAFGQSASQPELPKQVVGGRASIPEELEPHQLARLQNLKESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNC3</accession>
    <name>A0A084WNC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007500-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019806</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNC3"/>
    <dbReference type="STRING" id="74873.A0A084WNC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019806-RA">
        <property type="protein sequence ID" value="ASIC019806-PA"/>
        <property type="gene ID" value="ASIC019806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019806"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024372"/>
    <dbReference type="OMA" id="HITVNYA"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF220">
        <property type="entry name" value="LACHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="61"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="22107" checksum="40D6B63D39F64A5C" modified="2014-10-29" version="1">MCGLCCPCFGENREGGATYSGNVLNIHAVSKEDRGTYYCVADNGVSRGDRRNVNLEVEFAPVVTIPRPRVEQALQYDMDLDCHIEAYPPPAIRWLKDSVQLSSNQHYQLSQFATADEFTDTTLRVITAEKRQYGEYICQATNKLGEAEGRVEFTESVIPVCPPACGQARYGGDASTVTVSSFLLLVATILAVVAAAQHVKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPR8</accession>
    <name>A0A084WPR8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP000065-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00020322</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WPR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020322-RA">
        <property type="protein sequence ID" value="ASIC020322-PA"/>
        <property type="gene ID" value="ASIC020322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020322"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000682"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014391"/>
    <dbReference type="OMA" id="YAKHHEF"/>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
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        <property type="term" value="P:synaptic transmission, glutamatergic"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein unc-13 homolog B"/>
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        <property type="entry name" value="protein unc-13 homolog B"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="C1-like_sf"/>
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        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
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        <property type="entry name" value="Munc13_1"/>
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    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
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    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
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    <keyword evidence="5" id="KW-0106">Calcium</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="1315"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1422"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="10">
        <location>
            <begin position="1722"/>
            <end position="1837"/>
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    <feature type="domain" description="MHD2" evidence="11">
        <location>
            <begin position="1948"/>
            <end position="2114"/>
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    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="2133"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="279"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="563"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
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        <location>
            <begin position="902"/>
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        <location>
            <begin position="1070"/>
            <end position="1114"/>
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        <location>
            <begin position="1142"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1244"/>
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    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1878"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="551"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="906"/>
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        <location>
            <begin position="939"/>
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            <begin position="1232"/>
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        </location>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50004"/>
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    <evidence type="ECO:0000259" key="9">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    <sequence length="2263" mass="249848" checksum="F39F6484D9E727D8" modified="2014-10-29" version="1">MDENEVMAAFLWSKQSQEMYSNQGLKDLHHLHQDFIINDYTDKIATNIDLLDTELKFAWAALNLLNEEYTKMSEKVFKLQSLNISQQRIVQNLQFMEENRKAYLDMIPDYAKHHEFSLQEQSRLRKDLEYRDRINEALLNSGMIPLQEEQEEFMHRHQLQQQAQHQENLFHQQLVNSAHMYHAGMQLQHVGQHAMYDGKHALEQQRLQLQQQQAQMPFENEFLMLQRNLATVPEVLQEQFVKLIPQAGAHMHKPQLESGGGGATLQKPEPTRISTNPFLSAGEADRGLLRNIEPADSAAIIEEQLRTSFLNHAKQIELEFGTPKSKRFSAERIEKMQSEEVRELINKIMSEEDVASLSSEEMDKVRCFMAKNCSELMDVFDDDLQQVVHPVKTAELLLARHKQAPGVSPKKDLLPKYLPEGIATLTKDDLLTVENGTITIQDSASESDFRLNLNANTLDVGLVNGEGTSPKKLIEFSPFGLQATGMMVAGELVAHTEASTVAELNKVPSQSKQAPLPVDYHESGHLVNHYAVSEAAYVEAANQRTSAAKQPTTTTVEEPKTTIPPTFACSNLVGLTNGKPLHPSLRPNITEALEMTTCVASQSLPPTTSIVETMDVRKLSGAGIICSETVVTSSSRKASVSEVVVKPPVSDTTDTAAIIQAIISRRSSVAEPSTSPPTFQPLPGQTSITDSPEMQAIYDSLSRKSSIPTLSDTLFFPSLDITDSGFADTSDSLALFSQLPLTVPVGEAPVSLPDFSTMSAISNMPDNSDCSSFLHMSMNSSGISEASDSIAFSQPTLASTDHPPKDSMAPSLTGKLSTLPAILATPTPTLTALAESKPIAEATAPLAPTTLTAVTTAAPTAVTTSASGKVVVASGKPTPAPVTAAMSTSNAKPAVTAVVSEKEPFTRTTAQASSTTTSVVSSTPAGSQAVSQPPPTKPTLPATTSAAKQPPPAQQPPSGQSDQKGGFFQATTVNLGSFFNKVNKNLTHQESSDSTIGLKSKSFFASMKSSFSLDSSKASVDEVEPQPVQSSASAAPAHLDSTQVQLPELSPGAEKDVTPGAESAFHEPVLDMYPNGAGQNQPLPGQQPSPPREAHGGSYEVSPTMPQQSPMNEQGVEESFGYVADGELGYNGATAEDALYGANGTQPETPVALEKDAEPASQQRRQSLFRTQGSEDGEGGSKWKLLKTLKEKRIEEKQKVVEVGESFDDEPGLFKKVDVSGKNEEPEKRNGTVDSGRNNGLGDNTFYSNIDSMPDIRPRRKSIPLVSELTMAATKRNAGLTSAVPRATLNDEELKMHVYKKALQALIYPISSTTPHNFVLWTATSPTYCYECEGLLWGIARQGVRCTECAVKCHEKCKDLLNADLCFAGASEKSSKHGAEDKANSVIAAMKERMKQRERDRPEIFELIRKVFAVEEKSHAGHMKAVKQSVLDGTSKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFNFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENVFHYLCEEALGAVNLPQTKGDDGWKIYFDETPEEIVDEFAMRYGIENIYQAMTHFHCLSTKYLCAGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSQEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYEFSEHALFSNSVVDVFTQLTQCFDVVSKLDCPDPEIWKRYMRRFAKTIVKVLLAYVDIVKSEFPDIMHEERTACILMNNIQQLRVQLEKMFESMGGDKLEEDAANILKELQQNLNTALDDLATQFAKSLEPRITGSVRELGDLLQQVKQQSSLFHAPPADDANLIAIEADEVLRPLMDLLDGSLSMYAQSCEKTVLKRLLKELWKIVIRTLEKTIVLPPMTDRTMVFKHLTDNAKNLAANAKIEDMSRLIKNHMSGKQDAKSVLGGVMDISKEMEKNLSPKQCAVLEVALGTIQQYFHAGGNGLKMPFLEKSPELQSLKYALSLYTQTTDTLIKSFVSGQGASEEGVSHDDASVGEVSIQIDVSSNPENGEQKIFVKVIAANDLKWTVPSGMFRPFIEVNLIGPHLNDRKRKFATKSKSNNWSPKYNDTFHFIIGNEEQLEFFELHICVKDYCFAREDRLVGVAILKLKDVVDQVCYWVCVSEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQH6</accession>
    <name>A0A084WQH6_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00020712</name>
    </gene>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025615">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020712-RA">
        <property type="protein sequence ID" value="ASIC020712-PA"/>
        <property type="gene ID" value="ASIC020712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020712"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11186" checksum="E8089C5E9E1E5BD0" modified="2014-10-29" version="1">MFATTKKMTKMATCSARRGHSPLAGATQWMVKPVGSIKEAPGRFLFGDRKAARSAFPLAQRSSSNPFIAVSDRPSTTLEPLQSESSRTLAPTSCLGPPTRVGASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQK0</accession>
    <name>A0A084WQK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00020738</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01025637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQK0"/>
    <dbReference type="STRING" id="74873.A0A084WQK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020738-RA">
        <property type="protein sequence ID" value="ASIC020738-PA"/>
        <property type="gene ID" value="ASIC020738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020738"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019019"/>
    <dbReference type="OMA" id="SFRLMRD"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000013">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013706">
        <property type="entry name" value="PDE1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08499">
        <property type="entry name" value="PDEase_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="503" mass="56100" checksum="3238CF0BA0C49033" modified="2014-10-29" version="1">MFETQSRYELWNSRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRKKSDEKPKFRSVAHAIRAGIFVDRIYRRVSSTALMQFPPEVVRVLKTLDDWSFDVFALAEAGNCMPVKYLGYDLLNRYGMIHKFKVPPATLETFLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQTGLMHWLTDLEIFATLLAALIHDYEHTGTTNNFHVMSGSDTAMLYNDRAVLENHHISAAFRVLKEDDCNVLQNLSRDEFRELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAEPQVDKSKALSLVLHCCDISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPFSPLCDRNNTLVAESQIGFIEFIVEPSMTVCADMLEIVLAPIAPIACNAGSGSEEKGDGPEPAAPGSAGSAKNGGDPNEKPNRFKIRKPWITCLAENKKIWKEQAVRDAEARAAAAAAEAAAAEAAAAAAAALEAADSSEGQAAADDGTDEGKGEEAETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS39</accession>
    <name>A0A084WS39_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00021333</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01026321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS39"/>
    <dbReference type="STRING" id="74873.A0A084WS39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021333-RA">
        <property type="protein sequence ID" value="ASIC021333-PA"/>
        <property type="gene ID" value="ASIC021333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021333"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001062"/>
    <dbReference type="OMA" id="WQSVCFR"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="518" mass="57374" checksum="ADCD1C6407A06AB4" modified="2014-10-29" version="1">MIGAVDLEPELYINKNLETEGSETIPLSEDIINPGGRIKLGPQDFELKKVLGKGGYGKVFQHPFIVELVYAFQTGGKLYLILEYLSGGELFMHLEREGIFLEDTACFYLCEIILALEHLHNLGIIYRDLKPENVLLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILMRSGHGKAVDWWSLGALMYDMLTGMPPFCADNRKKTVDAILKDKLNIPGYLTPDSRDLIRRLMKRQVSQRLGSGPTDGQAVRAHPFFKNVNWDDVVARRLDPPIKPVLASEDDVSQFDTKFTKEIPVDSPDETTLSESANLIFQVSDSGPGNVPTLNGFTYVAPSVLEEMQTRVTTPRSPRRMPRHHHGHHLLHHNHHLGGSSTSSGPNSLGSGGRMMPGGVAGGSGMENGNIPPHHLLHHPHNQHHHHQQQQPPHHQQQPLPHHVHNIPPLTQRTAVPAPHHPGQGPQPHPAQPQTSATASGSRPFGAASIARRTPPHLQPFAPRPSPQDEMMDVYPEMSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSL1</accession>
    <name>A0A084WSL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021511</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026615">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSL1"/>
    <dbReference type="STRING" id="74873.A0A084WSL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021511-RA">
        <property type="protein sequence ID" value="ASIC021511-PA"/>
        <property type="gene ID" value="ASIC021511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021511"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023458"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="438" mass="49093" checksum="84930534182E9954" modified="2014-10-29" version="1">MGQNQSAGSGGDKKDDKDKKKKYEPPIPTRVGKKKRKAKGPDAALKLPQVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQERLKPQEEKNEEERSKVDDLRGSPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFNIHTARMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVLYRKKEGTPEGLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT64</accession>
    <name>A0A084WT64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00021739</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT64"/>
    <dbReference type="STRING" id="74873.A0A084WT64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021739-RA">
        <property type="protein sequence ID" value="ASIC021739-PA"/>
        <property type="gene ID" value="ASIC021739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021739"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000817"/>
    <dbReference type="OrthoDB" id="5846619at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037645">
        <property type="entry name" value="KCT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16502">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16502:SF0">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17818">
        <property type="entry name" value="KCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785186" evidence="3">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB53408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021739-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="453" mass="49331" checksum="D9D35B920F7ECA5C" modified="2014-10-29" version="1">MEAIPLALLLFGLVTVVLTAPPGQKPVITTVQNTTSVVARDAISLTPASPIDRLKRVQQGCQDKNVDLGNDCLAFNQLVLEMAQHSVRSNDTEAIFIQELSRTVTADEDICTNLTEVVKNLPPPLKRDELKPFATAKHCVNSCYDKQGKDDTKDSCRLLYAGYKALVDKRPLDKLPIQASEPHQQQPDSKPSGALASNQETSLAKDKPYNGTLGGGSELAGPKIVPTVDGENIVKAGNKRLDKSESAAQPAVPAPQPKQEVLEKETNDGDTEQEGVDDVGNNFEDDAKDLDNPTQDGKDQSYPDESGERSAETNKDNANQDDQFPKPGGNPIVNDVVQQKGQLKEDELQDHVEMSRTSEIMQGSDPFYNQNDSNFFSYFLFAMFSCVVLYVAYHNKSKLMALVVEGRRTSNGRGGFSKGRKHTAAYRKLDSNLEEAITSGSGSGGHASSQIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTL7</accession>
    <name>A0A084WTL7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012977-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTL7"/>
    <dbReference type="STRING" id="74873.A0A084WTL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021795-RA">
        <property type="protein sequence ID" value="ASIC021795-PA"/>
        <property type="gene ID" value="ASIC021795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021795"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022098"/>
    <dbReference type="OMA" id="CRIGTNG"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="505" mass="56405" checksum="A7D323237B7FCAD4" modified="2014-10-29" version="1">MSSKLAVTLADKSPVCYQACPFRVSSQVTVVDDSDKFVPPENPLDQLASVSDGPATHAVSTIEWYRSRSHAFGTTRFTCIESLLKAAELQASETIKLDFNRCGYTNLHVQIALDTLLNRIRPQCLTELRLCRNRLFNPSLAQVLGNVLQEFQTIAYLSISFNTLDDDCIGILGDALSNSGVRTFEANHCQITDKGGSLFFTAMTYSDCIESIQLNWNHLGMASGVAIGKFLSVQRSLVELSLSGNHLYPESQSIVPLLQGLIGNEMLEGLELSWNGLRGEDFGRALVKAVPQSKLKRLNLEHNLLASEEMMFLVRMLKKSETLLELRLGGNSFEEESSQEIVRTAGRHTSLVLLSFGRFHFVSQRTAKLCEFFKRKTPSKQFTYQGVLLANPPRPVDLQEMLLERCRFLAMKPKKAKLKRDVGHLMLQFKGQQNAVLTRDEFLLAMKQFGAKLDRALIDALMDAFAAQKGYVDTGTMAEKYLSRHPTDPPEKAPKATKGKSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTW5</accession>
    <name>A0A084WTW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004530-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00021906</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTW5"/>
    <dbReference type="STRING" id="74873.A0A084WTW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021906-RA">
        <property type="protein sequence ID" value="ASIC021906-PA"/>
        <property type="gene ID" value="ASIC021906"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021906"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014529"/>
    <dbReference type="OMA" id="ESEWNLC"/>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="371"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="745"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB53659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021906-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="819" mass="91456" checksum="36E5D29C8B200519" modified="2014-10-29" version="1">MVAPEHRGHCAPKPMIGLSIAQASFTGTLKSRREQKRISDFLNRQSTSSGLGVGSSGASSLTLVAGSTREPPSESSLRKAHFENIREIFEKNNSKTAAAQQQQHQYPKVKLSTPQLTTPSAAMTSNAPSAGEPGTTGGSASTLGIPIDDKPPKIQACSGILGKGKQVIRPIAFKPVPYKCNTPNYGAPIGGRLTELSDRYGSTPSLGPTMSLHMMSSSFHQHYHPHHQYSTLTRKGSSTIPFKTYDSLESILKLPDSMVASYPNPSHSDIILTKYSFAYSLYHQQDGLDMAPSPSDSGISELEAALRDRDSELAYLRQTMEHNEQDKEKHWEQELNRLKAIHESRLRAGAQKVHKLEQLLMMQTFQLRQDKKRLQEDNARLHSDMALAKDQTEQQKSELCQLRLGAKELKDQNGDLLDEIQMLRRVISDLKERLEESEWKLCQKNGEIALMKTQLKEAQAEMAAKDHEIVQLKADQKLQNYDEISLKKSEIKKELDFDLEISQLNRIVIFKDQIIVLMNNEIQKLRKELSDISILRGYEGAPPGRYARYKKKLELVAQKFEEAERSDSNNNNNQTSNSGSNRPTEPPSTEKKESKSAVVPSAVISSSDIIRNYFNSKLEMDKKLFLSSQICNYSDEDKSNIIDAYGSGKQVGMADITLDLSSLLPGTLPVTAKSTADEEVPAIIATQETYHHQSSSDDDYKSMTPTPEHENEDEGSEAQPKEPPALKGSGKMVAHKAPLGTDGELERLQGELLACRENFEQEKAKWADEKEKVLIYQRQLQKNYVDMCKRTQQLEEQLKALQMKSTGDPARAEAKNNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTZ7</accession>
    <name>A0A084WTZ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022065</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTZ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022065-RA">
        <property type="protein sequence ID" value="ASIC022065-PA"/>
        <property type="gene ID" value="ASIC022065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022065"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022065-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="5774" checksum="72B409BED05B4176" modified="2014-10-29" version="1">MPTASMPSPCADVGKGSGKKEANGGGVGGGRKECAECICTGWVESCWKDGASPEWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUN6</accession>
    <name>A0A084WUN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022175-RA">
        <property type="protein sequence ID" value="ASIC022175-PA"/>
        <property type="gene ID" value="ASIC022175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022175"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004634"/>
    <dbReference type="OrthoDB" id="8191482at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785218" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12192" checksum="64AE9FCF09FA826E" modified="2014-10-29" version="1">MSVLNTVCFLLALVVVGCYGGNEDSFEYGLKASTPDRDQFQYKVLGEDDLTYGCYGYVDPEGKSHSTFYTSGPRIGYRLLKQDGKALDNPDLEAKWENFPKECNERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WV07</accession>
    <name>A0A084WV07_ANOSI</name>
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        <submittedName>
            <fullName evidence="1">AGAP002121-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB54051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WV07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001871-RA">
        <property type="protein sequence ID" value="ASIC001871-PA"/>
        <property type="gene ID" value="ASIC001871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001871"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000815"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB54051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6045" checksum="0A3DADD2CF56379F" modified="2014-10-29" version="1">MQFCPNGAPPCYRAKNGESVIAAEDKIRLKIVGTRVDATGIFAIGTLMDDYLGLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA13</accession>
    <name>A0A084VA13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative scaffold protein salvador</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000226</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01001015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000226-RA">
        <property type="protein sequence ID" value="ASIC000226-PA"/>
        <property type="gene ID" value="ASIC000226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000226"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7561" checksum="F8B65AD60B6771BD" modified="2014-10-29" version="1">MPTDTDWKCLSNARPSYQPFGRSYSNTTHSEMIDRKYTEDRASSGHRYGENEPRDNIPPERRGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAD7</accession>
    <name>A0A084VAD7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000617</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01003064">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAD7"/>
    <dbReference type="STRING" id="74873.A0A084VAD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000617-RA">
        <property type="protein sequence ID" value="ASIC000617-PA"/>
        <property type="gene ID" value="ASIC000617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000617"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021460"/>
    <dbReference type="OrthoDB" id="8046894at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000617-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="20990" checksum="55B382747976D5F7" modified="2014-10-29" version="1">MSHQQSTRAQYRVTREVKQASGDRESCKAYCGNLRIAHELQDTLAAIRRSSTKRQTKPILGERGVKTECYSGRSASCAEAEAGPAAAEEIEPVFYPFRPSASASAVKTDHPRGAGFDPVFSMLTDMSPSAGAQFYGAQIPAMGMNITNITTHMQKPSGRGPRDRTVPFQVDCLLTCSLKSLQSRTSVKTSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBM8</accession>
    <name>A0A084VBM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Interferon-induced very large GTPase 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001888</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524467">
        <property type="protein sequence ID" value="KFB35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001888-RA">
        <property type="protein sequence ID" value="ASIC001888-PA"/>
        <property type="gene ID" value="ASIC001888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001888"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001888-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8652" checksum="9EC39CE2BD77241F" modified="2014-10-29" version="1">MADDMHPFARSPTVRSSLSISSHHPWKPFGKATRKARKRTAQPRPGQPDECGASGRKMNPPDPSRSIRSVLRFAVNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBP8</accession>
    <name>A0A084VBP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524494">
        <property type="protein sequence ID" value="KFB35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002018-RA">
        <property type="protein sequence ID" value="ASIC002018-PA"/>
        <property type="gene ID" value="ASIC002018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002018"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002018-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="147" mass="16264" checksum="C43E18545E950B3D" modified="2014-10-29" version="1">MLIEQFFWRQHIVTKGFANESLPMVPTMMANLFSFCSVPHATQTRFHSRHHRRKRCHYRCQYFHLFLVFRSPSAPSSPPEVQMYALEQIRPAPAGQAGPAASPAGGVIPSVAPTTTLGLGARLPPSAQHRPENAACPGVPIPRTQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCD3</accession>
    <name>A0A084VCD3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein on Y chromosome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00002487</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524596">
        <property type="protein sequence ID" value="KFB35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCD3"/>
    <dbReference type="STRING" id="74873.A0A084VCD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002487-RA">
        <property type="protein sequence ID" value="ASIC002487-PA"/>
        <property type="gene ID" value="ASIC002487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002487"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022217"/>
    <dbReference type="OMA" id="WHIVNYW"/>
    <dbReference type="OrthoDB" id="5980302at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF6">
        <property type="entry name" value="EF-HAND CALCIUM BINDING DOMAIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="709" mass="80442" checksum="7321E75B7547552F" modified="2014-10-29" version="1">MIIQSLETPTEQTKFIVPQGATCFAYEPSKELLVSGGPDCDLRLWDIHRPEKPTVTLVGHTASITFLFVQDAGEKIYSMDQKKILKVWDVRNRVLLQTFSQFSTVLAKALPACAYYNERDRELVVASNKLFVVACCPAIALDRTDGDSHTKPVSVLLYNSLYKLIVSCAFDSFIIVWDHKMNRKMTIISEAHTQTKNGVQIPVEITAACFDEKQQLLLTGARDGSLKIWNISARTCVRSFHMEEDSEVTAVFWQGNRILAMGWNHRVVEFAAFSENDDYPRGLQWRKLHSDDILCAAVSGSLPGVMATCSYTGELVLWMLETGQPYRRYDAANPRSRIPIQLHPEESVGQKTRKIAPRRSIFQLSADQFLQRRLSRIVMPSGLEQMRLLSIQALLFLPTRPMSASFGTLLGSLDNGIVQVWSHHPDGEFVGQFNAVHMAGDRVLAMTSDAANRFLFTGTALGYIKTWYIENRWIPDEETFRVNKPWLRILFPFLLHDVIPGRAKRSVRVQPKPWLVNSYQGHRSCITGLVYLDGSELLLSSSSDRTIRLWTLGGRYIGLLGSPVHWEPLSASLPPSDGYRFRVPPDLQREVSFTTVKVLNGGNDDHHGHRLKTTIPRVGTKEHSKHTQPMQTYGEALREPILNSGVLKLPSKEPILRDIKLERFLPRIPVHGHMVDFPVKPLVYDRKVESILERTKSLKFMEPPTEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCU1</accession>
    <name>A0A084VCU1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002166-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00002702</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524621">
        <property type="protein sequence ID" value="KFB35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCU1"/>
    <dbReference type="STRING" id="74873.A0A084VCU1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002702-RA">
        <property type="protein sequence ID" value="ASIC002702-PA"/>
        <property type="gene ID" value="ASIC002702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002702"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008481"/>
    <dbReference type="OMA" id="PINGVWY"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20407">
        <property type="entry name" value="Tudor_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047367">
        <property type="entry name" value="Tudor_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="448"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="588" mass="64856" checksum="7BD5D60E1A849A58" modified="2014-10-29" version="1">MIAGRPLLFLSLPSLALIVGLVWYRRKFKPDAGDRGGEKSKECESMITSRSNTTADLEPDVKQTSSLPIQQSGNNNNGAENWDNCSGSGHSSAGSSRSAPIDIVPNKSPSKGDDMNNLLGRSHMLDNDQEELSFSPSIDLPGTVASRYPTNLMKFNQMMEPVKEPVIIRPTKTASLQSGYFRVPDENAKTTTQQQQPSPPPIQPEMKTHQQLQSSSQPPAEQNERLTESDSTNNNNNTSCEGNDAAFNGKPEETFDERAEQTGSPPLSICSMRSEDSGKGSSPPHSVGPSLTTYEFLVPAFLVAGMLGKQGVFVKHVKKETGANVIIKRNPDTHNSKICTLEGSQQEIKDALALIRKKFPQRRFPALTLKRIEISRVEAVIPISLMKDTCSSLPLVEGINNDVAVSCIINVGHMFVHQPLHPTYLSLSSMQKSLNESYTKSEAPHMPEIVPNAVCVVFAAGVWYRAQIVQLDQDSNMVLVKYLDYGGFSLLPPQNLRQIRTDFITVPFQSVECVLSNIQPVDESQNTWSEEATELFRRLTSNTMMQAQVAGYTAEGIPEIYLFSSIAKDNVVFINKEMVARGYARWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD92</accession>
    <name>A0A084VD92_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00002893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD92"/>
    <dbReference type="STRING" id="74873.A0A084VD92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002893-RA">
        <property type="protein sequence ID" value="ASIC002893-PA"/>
        <property type="gene ID" value="ASIC002893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002893"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023560"/>
    <dbReference type="OMA" id="NHPFFAI"/>
    <dbReference type="OrthoDB" id="5786980at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15186" checksum="E3B79B21A09D4BE9" modified="2014-10-29" version="1">MSPSETSACEDLKAFERRLTEVIACLQPPTLRWRLLLGVTSLVTFVGAFYWLTDPRTSIVPLIESLLNHSIFTISTIVLLILFMFGIHKLVIAPQIITSRTRNVLAEFNMSCDETGKLIVRPRPTNNARYMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD98</accession>
    <name>A0A084VD98_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002900</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD98"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002900-RA">
        <property type="protein sequence ID" value="ASIC002900-PA"/>
        <property type="gene ID" value="ASIC002900"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002900"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013018"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002900-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="213" mass="22831" checksum="86F5AC7192F6C6C2" modified="2014-10-29" version="1">MSFLLTPVLRSFPGVSSAVLLVLYVGCVCGQGFHDDMMEPEMSSMLAYSSFGHQDSEQPGEAIGYNLPVEVDEEDAPISIVPTAYAPVSPPFFGDTNQTGVSNATEQRMPELRHRTEMKSHKASIPGAMPSSHSEFQGSAIGAMTGPAGPPGTQADIGLAAYARVPNHPGNPIHQPQHSNQQSGQSSWTMSFDTTPIPIVQHMPPYQGTRKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEE9</accession>
    <name>A0A084VEE9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00003521</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012275">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEE9"/>
    <dbReference type="STRING" id="74873.A0A084VEE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003521-RA">
        <property type="protein sequence ID" value="ASIC003521-PA"/>
        <property type="gene ID" value="ASIC003521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003521"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014099"/>
    <dbReference type="OMA" id="DGEWECQ"/>
    <dbReference type="OrthoDB" id="10039395at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="151"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="261"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="348"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="609" mass="67517" checksum="139D8AAC6C3FAE51" modified="2014-10-29" version="1">MLIALFWPRWPILYHFPFFIFLILILSLSLVFRTVTIGLQRFAEQPKYTEVNPGQDALLVCKVIDKRGVCSWQKDNKPVGIYPKKYEWASQYGIGQTAHVGGDCSLWVRAAQLEFDDGLWECQVTASDFTTQDALTSQPVRLVVRVPPQRPRLEYEGVHVPPGHNVTVDSGAVATVKCVSHYGNPPAQLKWFLGDQEVSPLHPQTNSTEPDNPRTWSAASVVQVPANKERHGTILKCLALHESYAARSVAVEGRLDVKYAPSVRLLGAPQIDLEEGKDSLILRCVADANPPASIVWRRAGRSEIASLQESLQLRPVGRRDAGMYTCQAQNSVGTSETMSVQLDVKYAPKILSAGPDRLTTAPLFSPAAFECVAEGNPAPTYKWVQRISTQGKPFLDRGRESRLVIDNVTYDYQGEYECRATNFINGQERTATSDPIALQVVGAPQVLRTTSASGGAVGHSVSVRKGDSATLSLIVCADPRPRHVAWEWGSLRLEAGNGIGRYRVDDVTQDSREDCYLATLHIADADLQDQRPYYLVVENDRGTDRHAINLRVEGMFSVVEPLELSYLLGIAGGCLAAFLILICLCIYAVRARKCCFRNRNNYKTSEKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFA3</accession>
    <name>A0A084VFA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003703</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012369">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003703-RA">
        <property type="protein sequence ID" value="ASIC003703-PA"/>
        <property type="gene ID" value="ASIC003703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003703"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="22463" checksum="78850218AE37375E" modified="2014-10-29" version="1">MDVQIEAWIDGTQTSNRPPIAFFPQAWNVCPVPVWTSLNARGRSIKSTQSDNRLPSLEHDHGSKTIGDSFCGTCGNRRHIPGGDHFEEAAMAVGALRAVLWLDLNLYLCPLMVVEEAWRAKGKDVTFFARGTSTATIILYRSRFSATGTTNGVQSGAICKSESFVKSLLSEPTQLTRAPKESNACQLLASELEGNSIALRSGTGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFL1</accession>
    <name>A0A084VFL1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase Suv4-20</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00003912</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01012443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VFL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003912-RA">
        <property type="protein sequence ID" value="ASIC003912-PA"/>
        <property type="gene ID" value="ASIC003912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003912"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19186">
        <property type="entry name" value="SET_Suv4-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044426">
        <property type="entry name" value="Suv4-20_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="418"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="737"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="809"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
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        <location>
            <begin position="1094"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1173"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1280"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1345"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1831"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
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        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
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        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
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            <begin position="841"/>
            <end position="871"/>
        </location>
    </feature>
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            <begin position="873"/>
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    </feature>
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        <location>
            <begin position="921"/>
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        </location>
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        <location>
            <begin position="973"/>
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        </location>
    </feature>
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        <location>
            <begin position="1121"/>
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        </location>
    </feature>
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        <location>
            <begin position="1175"/>
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        </location>
    </feature>
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        <location>
            <begin position="1354"/>
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        </location>
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            <begin position="1840"/>
            <end position="1855"/>
        </location>
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        <location>
            <begin position="1856"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1969" mass="212108" checksum="77782CE1DAEE648D" modified="2014-10-29" version="1">MTPKELSDNDDLATGLVLDPILGFQTHKMSLKYRPLKANNDEIKEIIEEFIRTQNYSRCYQRLISGHWMPRSLLNKNKLALKRLEAHIYRYLRVFDQHSGFVIEACYRYSLEGQKGAKICSTRRWAKNEKIECLVGCIAELSEREEEMLLHPGRNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFVATGRDTACVKVLRDIEVGEEITCFYGEDFFGDNNCYCECETCERRGTGAFEARARLLFNAAAAAAIDGTGNGAVDGLGGANGTIGAGGCAGVELSAGADSSGYEARLSGVVSGGVANGGVPVMGSAVGVNGGVRYRLRETDNRLNRMKSKGQSGLVGAVDGGGTGVIVGALGQGGGKTAVGKEPPSALRLLTMKELREKGMTKYDAEMLLAQQPKAPYCSVTAPAVGSSEQAAELPSTASQNQHGNNSAPKADAHTKRATRNSKGAPAACDKSGTSNSSSSSSSSKAKQPNSKVDEGAKPPAAARPLRRNVLRRHSCYDARAMPEREGNAPRGKATARKSREKEGPPEPILLGVAGRTRSRSKDPSDSFSVYDECSNQSSCASKSSYDAPGSGARKLQLRRASMHSSVSYASGRRSVFRFNDEPFDDEVVVVPDEPDDVLRSDDSTLNKSSRSTSSSSHRKHQSTATTEGKRKRAAEAPQPEEKRPASTQRGKTSYGIVTRRASQRYTTAASSPLTGGTHSSPARTDPETAEDEICPRVTRRMLRQMEDTSSNGGHDHSLVDGAADDGVPSRRTATKTPPPEGFSVPANRGSRRKQKLQTRTLEDDDDDIIQLLDVDSPTTTTTTTTNTTNTTNTTIANKKDPTKMVGCGRGTSQRLADSTAQDPSSGSSCRMPTRSLQAGQEPSGVGSSPVIISSASSTSSMNSAIDCRSSARALRKARGSERTKTPPPATATTTTTATATSASSSSLAEPTTSTSMMRTPERRLKLTLRMKRSPVIDEIIESGNSLSDGGAENGSSPGTAFRREYEILRVEGVESLHDPEDDPDGATSSAARHRHRKHLLTCDSISSSDSAIGGAKRKLLLDAIPTGDHQRNASSSPSTTMIVPPVVDKHQQQQHLLLAGDHLPTEVPSSHSSAVPGVFGFPRNQPGSAHHQHNHHHQQHNHHQKTVILQSSALTSKPPEGTDAGGGGSTTRCGEVYPLARTASSSSSCSSTTCSVPASPGSTSSSSTDKGPPMKRLRLIFGNETHTRDIPPMFAIYQTDPGTVPPAVAEQGAAKGQQRASVVAINNTPGVIVSPARTQSVGLVGLGTQPPSLHHQAPGDPRSLCPVQSSSRGVIARGDAQSTALDSNHVADVGSTSVAGASQPQQHILPHSRTMPLYLNGGSQQQQQQQQQQQQPVPTTTTTSTTTTFPPEQPSQRSGGCVGQQFVIQHTGQQSARRALGSHIYAVMSAIRRITQLLPAHFRPAVACDGEDSSDAGSDELLVGDNWTDCLPALCTEAVAFNRSTLHWIRTAVPKDEGALAARLGNCATEPYVKALVGLLARLATEQEVFGERLAWLQQNLQDGGPVSRERLAEDSTTLQHLAQSIGRLRSEFKQSVEAGGIWGHRAAHLRKEPSGGGGGGEGGSGDEARAADVSLSAIDSLGDLEAHEATTNPELAPLFRAMPRQVGLRLMLHIYQVRGWTMSIIKMLPMDFRPDIVTEVCGGVGSCDEEEAASIANLMPLCAATRVMNWSTVNWIRDATPLAPGREHERAVDILGRRAGKCSRAYGRALVSLLWRLRSSLDTFDEKLAWLQWSFDTLQELAGNDRHDVTMRAGWVEACSALDGIAQGINGLRRDFEQTEEGNWWRWWRWVNQLQPLDGEQERRRTQPPMSTVTSGSSTEVYNQSHQLQGQHEQGQQPLQQQPVQQNRPPHLTVEQQRDIIDQFLLHSMSSNPQQKQRRQAKKPQWQMKAPRYELLLNPMPDGRTQIVVNPPDVLNLTYSRAASSKVDGTPSGLPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG94</accession>
    <name>A0A084VG94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012729">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC004170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004170"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759821" evidence="2">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="15201" checksum="B1056F2AF89CB74E" modified="2014-10-29" version="1">MIAVHVCFTLTVFPIAGLERNHPGSKGDLGWQNPLPVLGGEKKKRSPNGHLHNPPRNVNCNCQSDKVGSKLKSAVARRAFRVAVDHTVPLVGLRATIESLKVTGIQIEVNMFSDVADELRRLVIVFDCRSVSIQQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGB0</accession>
    <name>A0A084VGB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004179</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012753">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524812">
        <property type="protein sequence ID" value="KFB37004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004179-RA">
        <property type="protein sequence ID" value="ASIC004179-PA"/>
        <property type="gene ID" value="ASIC004179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004179"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6276" checksum="2A17E8D427CAC14D" modified="2014-10-29" version="1">MAVSNVVPANRNRSGFTTQHVVIASILPLFGLRSPCPSWMVIKRLSADVRHGGMMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGM0</accession>
    <name>A0A084VGM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP003769-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004316</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524833">
        <property type="protein sequence ID" value="KFB37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGM0"/>
    <dbReference type="STRING" id="74873.A0A084VGM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004316-RA">
        <property type="protein sequence ID" value="ASIC004316-PA"/>
        <property type="gene ID" value="ASIC004316"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004316"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021377"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004316-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="940" mass="105882" checksum="1461FF63ED30B046" modified="2014-10-29" version="1">MAAGDQDNFQQLMSSLLSTDNEIRTKAEEVYNALPRETKVPHLLGTIQNPAMSEEARMLSAVLLRRLFSAEFTEFYEPLPPEAKEQLKQQILMTLQQNEAGSMRRKICEMVAEVARCMIDDDGNNEWPEFLQFLFHCANGTNVQLQEAALRIFASVPGIFGNQQAQHLPLIKQMLIKYLDASSDQEVRFQAVRAYGAFILLHDKEEDVKRQFADLLPAVIHITAESIELGDPQNLMQLLIDMADGVAKFFRPQLEPIFELCMKVLSTPDMEDNLRHLALEMMVSLAENASAMVRKRADKYVAALVPLILQMMTDLEDDDEWSVSDKITEDDTSDNNVIAESALDRLACGLGGKTVLPHIVNNIPNMLLSPDWKQRHAALMAISAAGEGCQKQMEAMLENIMQGVLKYLVDPHPRVRYAACNAIGQMATDFAPIFEKKFHEQVIPGLLQLLDDVENPRVQAHAGAALVNFSEDCPKNILTRYLDAIMAKLEMILTTKFKELVEKGTKLVLEQVVTTIASVADTTEKDFVAYYDRLMPSLKYIIQNGNTDELKLLRGKTIECVSLIGLAVGAEKFMSDASDVMDMLLKTHTEGDLPDDDPQTSYLISAWARICKILGKQFEQFLPLVMGPVMRTASMKPEVALLDNDEMQGVENDANWQFVNLGEQQNFVIRTAGLEDKASACEMLVCYARELKDGFANYAEEVVRLMVPMLKFYFHDGVRTAAAESLPYLLDCAKIKGPNYLEGMWLYICPELLKAIDSEPEADVLTELLHSLARCIETLGAACLSNEAMEEVLKIIDKFMTQHFQKEEKRAQARKEEDYDDGVEEQLAEEDDADIYLLSRISDIVHALFVTYKETFIPSFHRVVPHFVKLLGATNSWADRQWGLCIFDDLIEFAGPMCAQYQGFFLQPMLEYIKDEQPEVRQAAVYGCGVLGQVGKFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGP5</accession>
    <name>A0A084VGP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">AcylCoA dehydrogenaselike protein putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004345</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524836">
        <property type="protein sequence ID" value="KFB37139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004345-RA">
        <property type="protein sequence ID" value="ASIC004345-PA"/>
        <property type="gene ID" value="ASIC004345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004345"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759826" evidence="1">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="19997" checksum="DABC38921EC8E164" modified="2014-10-29" version="1">MFVWAVAPSNVSLARSLALFLAIANRPCAPQQFNLPSLSLPSPPQYFMVPTITGWRPAVQNAVRRARQSQLELGASSKQRPRSGTNFLEHYKRNRSSIFPCVCDCVSLWWENDSGHCQTSLGGSSSSAYDIREFWCRLLKTTKARPSEANAAEQHINIHHHQQGDLPPVAMSPASYYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGU0</accession>
    <name>A0A084VGU0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Clipb17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004393</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524839">
        <property type="protein sequence ID" value="KFB37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGU0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004393-RA">
        <property type="protein sequence ID" value="ASIC004393-PA"/>
        <property type="gene ID" value="ASIC004393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004393"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004393-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10677" checksum="304DEE8F1A16B395" modified="2014-10-29" version="1">MQEISIDQRIVTDMYDDALRRLTNTPEVDGSMVRPICLPLSGVPVYANHRMSVSKTSHLLSKAESPVVLSEENHCSQSYKLCICRETVHTNCVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHA5</accession>
    <name>A0A084VHA5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004642</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHA5"/>
    <dbReference type="STRING" id="74873.A0A084VHA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004642-RA">
        <property type="protein sequence ID" value="ASIC004642-PA"/>
        <property type="gene ID" value="ASIC004642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004642"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009094"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="210" mass="22688" checksum="3CAABE05999AB65D" modified="2014-10-29" version="1">MAASGKFTVLARQLSTSSAAAQLVKPPVQVFGLEGRYACALYSAASKNKVLDVVEKDLKALQTQLRTDSKVRDLLRDPTTKRSLKATALKDVSDKVKYNAATGNLLQLLAENGRLARLDGIINAFRLIMAADRGEVVCEVKTAKPLDDGQRKQLENALKAFLKPNETIQLTAKVDPALIGGMVVSIGDKYVDMSVASKIKKYTEIIAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIA6</accession>
    <name>A0A084VIA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011652-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIA6"/>
    <dbReference type="STRING" id="74873.A0A084VIA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004960-RA">
        <property type="protein sequence ID" value="ASIC004960-PA"/>
        <property type="gene ID" value="ASIC004960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004960"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022786"/>
    <dbReference type="OMA" id="CAERFIT"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001440">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000038">
        <property type="entry name" value="spermatogenesis-associated protein 5-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF194">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="223"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="491"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004960-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="735" mass="81601" checksum="892660CEE09A9B18" modified="2014-10-29" version="1">MEPYRLSLDRDPKLEPAFSAPQTCCVWPKKSDRTEWKMFPGTPAICRLEDGRQFLWHIYGKLDRNSLHREAYFAYEAVELVEDVNDRKPICSSRLMEIYPIQDAITDFQKVILDVQLDCSRLCVELLLTKDCLCEMLGSLLMTTFFARNTRFDFSFLQHRNMGISAAFVRETDGPSFYGRIGADTRIEIGRILYHPGITQSTKLKPLGGIDCAQRQLEEAVSDRTSILISGPSGSGKYSMVKSLAVSRNLPLFEIRGLNFVRSLPGETEAELRKTFLRLQLFGELTCGETPVILLVKDIDTICPKIGSKKGEDVANVARIASQFVSLVDQYRESMENLIIICTTSMIENLDNRLRRPGRLGKEITLGIPSKVQREEMLRCFDSSQKLSEEQLTEMASRTAGYVAAELELLYCNVAREMARSNVPSFEDVLVEVQKKHRPSSLRNATGLIGRDLTLSLDSFAGMEKLKALLRLCIIEQLKDPARFHRLGINPLKGILLYGPPGCAKTTLTKCLAAESGMTFLSLSAAELYSPYVGDAEKLVTRLFNEARANAPAIVFLDEIDSLVGNRGAVGLKGAPAPVNMGILSTLLMEMDGIGQAEQTANALSGDAKRVIVIAATNRPDMVDDALLRPGRLTKLIHVPAPDADGRVAILKKLGETIPFADDVDVTLVAELTERYSGADLTNLCTQAALVAATEDLAVKTVSMAHFKEAFKDVRPSLTKEQIELYHNYEANRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ09</accession>
    <name>A0A084VJ09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cullin-associated NEDD8-dissociated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005122</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005122-RA">
        <property type="protein sequence ID" value="ASIC005122-PA"/>
        <property type="gene ID" value="ASIC005122"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005122"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005122-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7048" checksum="D131F44656D5D002" modified="2014-10-29" version="1">MGYEIDRLGWIARGWIEDIPQRVPTVIDRRRQSDAGEPGRLPSKGPRSEEIALAFNIVPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ10</accession>
    <name>A0A084VJ10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ubiquitin carboxyl-terminal hydrolase 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005123-RA">
        <property type="protein sequence ID" value="ASIC005123-PA"/>
        <property type="gene ID" value="ASIC005123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005123"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11674" checksum="CA719EA75EF39361" modified="2014-10-29" version="1">MGTPGRPRVGNRKSAGTHQLRAKKQTRSGRQWAPGERARRLHAVFRHRSLGSARPGDEALVRSCASGADVRAAAGSTVRTQRQSRWNMCSGRNGLLGAGCVRGGRSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJP4</accession>
    <name>A0A084VJP4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005499</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524901">
        <property type="protein sequence ID" value="KFB38188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJP4"/>
    <dbReference type="STRING" id="74873.A0A084VJP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005499-RA">
        <property type="protein sequence ID" value="ASIC005499-PA"/>
        <property type="gene ID" value="ASIC005499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005499"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022911"/>
    <dbReference type="OMA" id="CRIVFIE"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000370">
        <property type="entry name" value="GM19574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783467" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="8">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="25048" checksum="40BFFB7812155602" modified="2014-10-29" version="1">MAFFTSCLLLLGGLLLVRLVQLLIAVRRSQRATDVTPRTKPARTMIVMGSGGHTAEMLRIVERLDSDRYSPRQYIIASADKTSVVKVIESEIRRQPDPAQQTYEIITITRSREVHQSYISSVATTLMALVNCVPIVLKARPELVLTNGPGTCVPVCLVAFLARLLFLNTKCRIVFIESFCRVNSLSLSGHILQYIVDMFVVQWPELIQHTTATRDDVRCFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJS1</accession>
    <name>A0A084VJS1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005529</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJS1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005529-RA">
        <property type="protein sequence ID" value="ASIC005529-PA"/>
        <property type="gene ID" value="ASIC005529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005529"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11806" checksum="6F78A9ECB9DB4940" modified="2014-10-29" version="1">MESHYLGQYLPDGILLTEAARRPSSPHRGSMKEFERWEKPLPPAIVETTTTTAHVIPGETPIPTLELDDVGGGFLTHVHRNEIHKALHFREPAFFRVADKNGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX4</accession>
    <name>A0A084VJX4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dpse\GA10537-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005589</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005589-RA">
        <property type="protein sequence ID" value="ASIC005589-PA"/>
        <property type="gene ID" value="ASIC005589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005589"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8770" checksum="223BA6B6A8E03291" modified="2014-10-29" version="1">MHLFSPRDSDYISSPDGGTVNASANGGLHHGMQSTSILAAAQSLAMALQQQSSSFHPSPDPITADIINTWLDTHIPLLNTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK49</accession>
    <name>A0A084VK49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Type VI secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014111">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005696-RA">
        <property type="protein sequence ID" value="ASIC005696-PA"/>
        <property type="gene ID" value="ASIC005696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005696"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14570" checksum="97CE7E5D17F583ED" modified="2014-10-29" version="1">MLLVRGEISFTDLRILSPFWKQRPFVIASEQTPSAKGQPFAPGCPTAPPKDGYAVTTVGLPTRLRVTCEYASDHESQKRPFRFRPFAGRLLRGDFTLNERSPNPASSLSRVSGPVSPAGRNPLEIGVASLFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKN7</accession>
    <name>A0A084VKN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011225-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005807</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKN7"/>
    <dbReference type="STRING" id="74873.A0A084VKN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005807-RA">
        <property type="protein sequence ID" value="ASIC005807-PA"/>
        <property type="gene ID" value="ASIC005807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005807"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018137"/>
    <dbReference type="OMA" id="ICARYDE"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="277" mass="32308" checksum="1FE7C51B448479A9" modified="2014-10-29" version="1">MYAIEETLKQSVKTSEDNTREKLEDLRNHVISKMDSIVQQQVAETKTIQETTQVELMKLMPLIKLVPLRSCRQAPKNESDKYMIKPGINTQPFEVLCEQTKFGGGWTVIQHRFDGSVDFRRKWTEYRNGFGKLDGEFWLGLEYVHQLTKNRPHELLVEIKDFHGNYGYAKYDEFEIGSETESYALKKLGTYTGTAGDSMLINWDEKFSTFDRDNNYWRCSNCAENQFGAWWGWHLSNSNLNGRYQNTTGDASAMYWNHSKNDHGGLSYSRMMIRDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLM9</accession>
    <name>A0A084VLM9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP000235-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006364</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014527">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLM9"/>
    <dbReference type="STRING" id="74873.A0A084VLM9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006364-RA">
        <property type="protein sequence ID" value="ASIC006364-PA"/>
        <property type="gene ID" value="ASIC006364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006364"/>
    <dbReference type="OMA" id="PDKEAIQ"/>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14433" checksum="C3C5551CDD135FB6" modified="2014-10-29" version="1">MESAGQEAAPASYPRVGADFKSELESFRPETLAKADTQEKNVLPTAADVKCEKAQRSVIEGIEGFDASRLKHAETKEKNPLPDQEAIQAEKGVQRFIEGIESFDPSRLKHAETLEKNPLPTAEIIAEEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLZ0</accession>
    <name>A0A084VLZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP009385-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006594</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLZ0"/>
    <dbReference type="STRING" id="74873.A0A084VLZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006594-RA">
        <property type="protein sequence ID" value="ASIC006594-PA"/>
        <property type="gene ID" value="ASIC006594"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006594"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020887"/>
    <dbReference type="OMA" id="HQFISID"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006594-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7796" checksum="B54EBEA9F6C198B2" modified="2014-10-29" version="1">MLVFIIYFHGNDLAKFHQFISIDKLPADFGGNLPAIDYTGLDWYPCVAAQIEHIEKYQRCGFVDDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMW0</accession>
    <name>A0A084VMW0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014631">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMW0"/>
    <dbReference type="STRING" id="74873.A0A084VMW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006658-RA">
        <property type="protein sequence ID" value="ASIC006658-PA"/>
        <property type="gene ID" value="ASIC006658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006658"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020923"/>
    <dbReference type="OMA" id="RSPEWFN"/>
    <dbReference type="OrthoDB" id="2378895at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006658-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="153" mass="16751" checksum="475F665E0A3234C0" modified="2014-10-29" version="1">MGSTAVEQENRLAPPMELSEDERKFRYRAGAFLATVGAASAIAGFSKAIMSAKKSDPKYFDKGLHGSIALHEAGTSLALRALGWGTLYAILGTGTICFGIWKLSGAKDMKEFRESVGRVFPRIPKNDPPKSRTEFEGLTDLMQYLSTWGKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN68</accession>
    <name>A0A084VN68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP012753-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006918</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006918-RA">
        <property type="protein sequence ID" value="ASIC006918-PA"/>
        <property type="gene ID" value="ASIC006918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006918"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7252" checksum="FB8817CD84CDC083" modified="2014-10-29" version="1">MVEKSDEVGKLCRFCLSREGLIALSNVTSTVVALEDVIYFTGVEKTLNVVRKLRNLQTLFGAMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNG7</accession>
    <name>A0A084VNG7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI/MSF1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006852</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014743">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNG7"/>
    <dbReference type="STRING" id="74873.A0A084VNG7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006852-RA">
        <property type="protein sequence ID" value="ASIC006852-PA"/>
        <property type="gene ID" value="ASIC006852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006852"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012139"/>
    <dbReference type="OMA" id="YCPWNEK"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="24149" checksum="D4F98C4FEB2F2DBF" modified="2014-10-29" version="1">MKIWTSEHVFNHPWETVAQAAWRKYPNPINTAVIGTDVVERRVVDGVLHTHRLVSSKWYFPQWAQKLIGSPNVCYASEKSTVDPRERLMTLKTINLTFGSFLSVYETLSYVPHPTDPSKTLLKQEATVQVEGVPLNRYMEDVLTKNISTNAGKGRQGLEWVIGKLNAEMKELANSAANSTNEILTHTKKSLDDITDQARKSMDELSATAQKIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNM3</accession>
    <name>A0A084VNM3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006405-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007007</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524985">
        <property type="protein sequence ID" value="KFB39567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNM3"/>
    <dbReference type="STRING" id="74873.A0A084VNM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007007-RA">
        <property type="protein sequence ID" value="ASIC007007-PA"/>
        <property type="gene ID" value="ASIC007007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007007"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009160"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15011" checksum="D958B8C9863C21C5" modified="2014-10-29" version="1">MLPARNRLPAAEIAPQQGPALLGAAACALGLVLVVGLIASAMYVRARKQIRQDSLHTSFTTAAYGSHQNVFIRLDPLGRFRSTPSPSPYATALLPLGAPNGTTAMGTESVYAKPESVCPSRVSYYASSQLTQDNRFTLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNP0</accession>
    <name>A0A084VNP0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013498-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007033</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524989">
        <property type="protein sequence ID" value="KFB39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNP0"/>
    <dbReference type="STRING" id="74873.A0A084VNP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007033-RA">
        <property type="protein sequence ID" value="ASIC007033-PA"/>
        <property type="gene ID" value="ASIC007033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007033"/>
    <dbReference type="OrthoDB" id="7766426at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10900" checksum="27228267368DD775" modified="2014-10-29" version="1">MVLPCRYEDRIHYPVNGTALHSAREFSTSILGALRINMTSPLPLLRSFSTENQNRDWSKRFSLRIKQKSSNDGKLVSLGRKGEQKYTHHRLRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP37</accession>
    <name>A0A084VP37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007923-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014974">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007423-RA">
        <property type="protein sequence ID" value="ASIC007423-PA"/>
        <property type="gene ID" value="ASIC007423"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007423"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009356"/>
    <dbReference type="OMA" id="ATHGERY"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="573"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007423-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="815" mass="89832" checksum="AB39B2D5A140B3B0" modified="2014-10-29" version="1">MFWKLVPTYHSLCGSCLGCLQDFRNPTGPTENAGPTGSPPKRIEASGGGSTTCNNNYSIEGVKNVSGVGEIMTNGFHPDHDPIGPPESESVYRRLVRTHPDLVRMCQWCFFKRRKQTPATPGCPELTEITNVVPFDSASVFQTPQKKIIARDGGKYVREGLGIFESTPTNGPSSTSSSSNDAFISPNGYNETNGKQLVTAHAQKRDIDQQSHATPSKCYNNQTATGEPNNRSNSATHGERYFGDFVNGRRGSAGGGGGGAGTAPSTPSRARFLGDDLSNDVPVINQESYIIQRDEHYDSEQDERSSNDSTSTRIISNSIFNLRDRDRDRVTVLDDRGSFAPSVASASRPQSVSSHKSIGSGALKQQQQLTDGRLSRTSNVSYARNHSASDNVSLKSNRSATGKSPLANEEGEWYGERAATPITSEIDGISSNQIQYESDYDVEDDDARKEDSNGQVARPMGTPKRYPTPSPLPLQGSYSTENLSMRNAFHHEAHDDEDEEIEEEIDTLPRSRGQSASLGNLRHLPNDEDRTGNDEPPVGLRAAPKKKKPFLVRRSSRVAPVKEAASGVKTKNKLNEVIFQKTLRKFDKPKDALNNCLSHLESPNWEQNISGLQFFVRLIRHHPEVIDTQIHLLSVALAKQVRNLRSQVARAACQASGEFFSTHRRCIEGEAEDIATHLLHRTADTNKFLRADATQALESMCDNISIPKVVHIIAFKGATHQNAVVRTTAAKLLDKIVQKIGSEKVFALPKETRDKLILTGAHLLLEGSLETRNFTKSVFRQLSDHPNYSKVLLEVIPSRTYRNIEKSLNSIRQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQQ5</accession>
    <name>A0A084VQQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP007302-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007785</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQQ5"/>
    <dbReference type="STRING" id="74873.A0A084VQQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007785-RA">
        <property type="protein sequence ID" value="ASIC007785-PA"/>
        <property type="gene ID" value="ASIC007785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007785"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009563"/>
    <dbReference type="OMA" id="VHWNHPR"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF76">
        <property type="entry name" value="FI02861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007785-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="571" mass="64675" checksum="AAE606762A7B4FD7" modified="2014-10-29" version="1">MNTEEFRKYGKQMIDYICDYGQTIETRDVAPTVDPGFLRQLLPDEAPQKGEDFKRMLDDVETKIMPNMVHWNHPRFFAYFPAGNSYPSILGDMLSSAIGSIGFSWASSPAATELETIVLDWYAKALDLPCFFRSDAKGSRGGGVLQGSASECALVCMMAARARAIKELKGNHHDVHDSVYLPQLVAYASKEAHSSIEKAAKMAIVKLRALDTDCRGVFRGDTLRQAIQEDMAQGLTPFFVVATVGTTSACVFDNLVEIGQVCREVRSIWFHVDGAYAGNSFILPEMRRFKEGLEYADSFNTNPNKLLLTNFDCSAMWVKDVKSLTTALAVDPLYLQHDHSSAIDYRHYGIPLSRRFRALKLWFVFRSYGIVGLQKYIRNHIALAKRFETLVNSDDRFEVRNDVNLGLVCFRLKQQDRINRDLLARINQSGKFHMTPAMVRGKYIIRFCVTYEHATEEHIDYAWEEIKNYAEETLAAECPEEITEPVVTAAAKKPPKKLTRSMSTRFSFTRSVSREIFERQNSRSQLTDGCTPIVIIDTDDILESLQRASRMNGERNSNDTYDSDSTDEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR40</accession>
    <name>A0A084VR40_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">c-Myc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007930</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007930-RA">
        <property type="protein sequence ID" value="ASIC007930-PA"/>
        <property type="gene ID" value="ASIC007930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007930"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7808" checksum="CEBF001E43842FD3" modified="2014-10-29" version="1">MAHLAPPSLLQFLKHHPLCVQCKYLRVEAYQVKAKWRGCRTISENKRFGEERQDGCFIGGVQMDREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS37</accession>
    <name>A0A084VS37_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00008212</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015797">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS37"/>
    <dbReference type="STRING" id="74873.A0A084VS37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008212-RA">
        <property type="protein sequence ID" value="ASIC008212-PA"/>
        <property type="gene ID" value="ASIC008212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008212"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004285"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000062">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 11" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="13">
        <location>
            <begin position="578"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB40781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="691" mass="76577" checksum="B68652EFD1E80E52" modified="2014-10-29" version="1">MSKAEAKEATIRQLYTELNKHCGSAEYDKALKAANKIIALDSSEWKAAKCKLVCLIQNGKFEEVLKFLDRGTSIPDTTFEKAYSEYRLNRAEDAFRTIQAVAGSAGASVEQWAGLAPNLKELLAQVLYRLERYDECFELYRSIIKNTHDDYDDERRTNMSAVAANRCIVAGANGDQTQLPEDSYELAYNAGCALAGRQQYGEAERKLRTSEKMCREALEEDGASEEDIIDEITIIKVQLAYCLQMQGRVKEASALYADALRHKTNDAALTAVVSNNLVVINRDQNVFDSRKKMKVATSEQAEQKLTSRQRKTIAFNNCLLAYFASPAECGLLASRLAVAHPELEFQSLLIRVAQLARDKKYREAIELLESYAQKLPRERTVELLQVRFAIVQLQLVAGNRRAAIETLEALGDARYRPGVVSALVTLHLGLDNKQAASEILKSAVDWYKRQKGGISDADLSDMWRQAASFHLRGGEPATAAKSLEELLRTHPNDMKLLAQLVIAYAQFDPAKAQQASKRLPALETLTTVSEIDALEATNWMMIAKAVRRKQPLPGGGASGGGARGTGADQSPGAGTPAEQRRQKRKKRKGKLPKNYDASAQPDPERWLPRYERTGYRKKRDRRVKEVIKGSQGTASGQADQYDMSKVYNQAKQSPATPGAGGSGQHEQTAAAAAATRQLPRKNQHKKKKGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT07</accession>
    <name>A0A084VT07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008559</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008559-RA">
        <property type="protein sequence ID" value="ASIC008559-PA"/>
        <property type="gene ID" value="ASIC008559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008559"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="12829" checksum="A12FFE35CFFDCB7B" modified="2014-10-29" version="1">MQSERRSLFRFAQPPHDDDRAASNEGRNSNDVKTLNIVGDLRANRRDVCGNLEPTESCYAGSDETAPLDGEKMANQCCAEVWGYSFCCEPTVGAAGTLAPWHPEDDGDDQGDYDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVQ1</accession>
    <name>A0A084VVQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP000874-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009627</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVQ1"/>
    <dbReference type="STRING" id="74873.A0A084VVQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009627-RA">
        <property type="protein sequence ID" value="ASIC009627-PA"/>
        <property type="gene ID" value="ASIC009627"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009627"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001260"/>
    <dbReference type="OMA" id="RNKMHIL"/>
    <dbReference type="OrthoDB" id="10069059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="744"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009627-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="798" mass="84383" checksum="8B0ADE00D5F5606A" modified="2014-10-29" version="1">MIDNGYSYVTRDNLRYTDLNDGRSYIQMGTLSSPMATNRGLVEYDTSVSHLTNHRPYEPAPQTAFERYDTAYAPQRSNLYPSAAAAAAAYGYGQPSIIDDEQKYLTADSTPHPEVAAQQQQQQQQQHQQQQQQQQQQQQQHQQQQQQQQHQQQSQQSQPPHPHHHHHHLGLVSPASDSRPHHTMMKVEMDETTGPIYPRPMYHYDPSACATTMPPGFSAINLSVKESSPPLPPYKANSGSPSPNGRRPGDERVNKLAPASPEPEPSPVQRRNSSPPSSLDLSSNTSGGTSPQFQTNRQSAAPTNGNNPATAPAPNSNGNGVYTSEVSDSRAPPDVNGNDYNGGAERPLGMGFARPQPPSAPYSRESTPDSGGSYYADSYRDQSGYSPHASYGMVVQPDYSNGYPGYAPNAYQYSGPYASSLGTTVYPPSVPSAYPASSSASFVAPPSLGQHIAPHDNLLKAGLTGYQRLERPQFPSQSQELKCPTPGCDGSGHATGNYSSHRSLSGCPRASKPKSKPRDGQESEPLRCPIPGCDGSGHSTGKFLSHRSASGCPIAFRNKMHILENGGTIEQAKAAMAQAAAGKFEPFTCPTPGCDGNGHVDGTFSTHRTVASCPTAQGQQAPSSKKPRYADTDTVLGGLGSATAKSFNDLASGYNPGVKMAGPGPLLVGPPHPALPPQPAPAPAQSTVLPGLGHPGVGVGGHGVGSQEHASPAPVGSTPAAAVAAATDSSSGAGGSADSGAEDILALDEEITELKRENARVELQMLRLKSNINAMESQLNNNVGHEPKLLEIGTRGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWP3</accession>
    <name>A0A084VWP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001799-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010080</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017680">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017681">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWP3"/>
    <dbReference type="SMR" id="A0A084VWP3"/>
    <dbReference type="STRING" id="74873.A0A084VWP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010080-RA">
        <property type="protein sequence ID" value="ASIC010080-PA"/>
        <property type="gene ID" value="ASIC010080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010080"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017646"/>
    <dbReference type="OMA" id="HHARESE"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="32470" checksum="B58D22E918E705E2" modified="2014-10-29" version="1">MDAIKKKMQAMKIEKDNAQDKADTCENQAKEANLRADKIMEEVAELTKRLEQVTQDHEKFKTTLEQATKDCEDKDKLLTSTEANVAALTRKVQQVEEDLEKSEERSSAALSKLLEATQSADENNRMCKVLENRSQQDEERMDQLSNQLKEARMLAEDADSKSDEVSRKLAFVEDELEVAEDRVKSGEAKIMELEEELKVVGNSLKSLEVSEDKANQRVEEFKRQLKTLTIKLKEAETRAENAEKNVKKLQKEVDRLEDELGVNKDRYKSLADEMDSTFAELAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWU9</accession>
    <name>A0A084VWU9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Structural maintenance of chromosomes protein 6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010143</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010143-RA">
        <property type="protein sequence ID" value="ASIC010143-PA"/>
        <property type="gene ID" value="ASIC010143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010143"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="25967" checksum="231D3577E0CDB06D" modified="2014-10-29" version="1">MMMAQMAGSMDNAGGRMRDRSSMVRDRGGIVGDRGSMMGNRGSMMVLDGGVSYRSMGVAGHMDGLSDHFVHWLGDLHSSGFTTDDGVESGVVVGVVVDDAVVAVGVQQRVLAMDLISVARLVLALDVSGVLVMDGVRELVVGRSMVVVVVLMMSIGLQDRGLSDGLDDGGLVLVHSRGGVDGSNVVDRGGSVVLDGGVRRGNGSMVSSRKQTSAGGGDQSGQENELKNGRTRINIFPMFTDMLLLEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXN2</accession>
    <name>A0A084VXN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">(NiFe) hydrogenase maturation protein HypF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010467</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010467-RA">
        <property type="protein sequence ID" value="ASIC010467-PA"/>
        <property type="gene ID" value="ASIC010467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010467"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8034" checksum="D540D874ECDCEB99" modified="2014-10-29" version="1">MIKRINTPPQNPPRGDVDHTACLWPRSITFIGVPRCQEPPPQQDEIGSYSDLSHPHNPVPITFAEDAETFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYU3</accession>
    <name>A0A084VYU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010908</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525234">
        <property type="protein sequence ID" value="KFB43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010908-RA">
        <property type="protein sequence ID" value="ASIC010908-PA"/>
        <property type="gene ID" value="ASIC010908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010908"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="14916" checksum="1EE0A1BC17250377" modified="2014-10-29" version="1">MVRPVHESVFRSVGVVLLNEMIVQMKGGRKHASLHPAGFQASEVRLGETRVAVGKYCQIRQKAIAFHRTGAQPVSHLQAGRPSACQVARSGAVAGSVPVCFLARGQPYAIWYGHWAARATNHRRRTERICSSPEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZW8</accession>
    <name>A0A084VZW8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dihydropyrimidinase</fullName>
            <ecNumber evidence="7">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00011374</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01019006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZW8"/>
    <dbReference type="STRING" id="74873.A0A084VZW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011374-RA">
        <property type="protein sequence ID" value="ASIC011374-PA"/>
        <property type="gene ID" value="ASIC011374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011374"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005932"/>
    <dbReference type="OMA" id="RSSIKVH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000076">
        <property type="entry name" value="Dihydropyrimidinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="147"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="473"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="729" mass="79821" checksum="22F1DA902531AA88" modified="2014-10-29" version="1">MSKGAQDSVTTLEDVSTPLVEGKSSHKLPSDKALSSEKTDTGTQVVAVTTESSTNTVEETESVKYIAPGKVTGKVLKGRRMEPEVEVKKEAKSAQNRLYIKRGHVVNHDGVQHADVYIEDGTVRYVGSGADFVVPGGCRTIDATGMLVIPGGIDPHTHFQLEFGGTVSVDDFYKGTKAAVAGGTTTIMDFVLPKKGESLLEAYDTWRSRADPMVVCDYGLHVGITWWSKSVRDEMRILCRERGVNSFKCFMAYKGLYQLNDSELYEVFETCKELGAVAMVHAENGDIIAKNVTKLLADGVTGPEGHELSRTEEVEAEATNRACVIAHQAGCPLYVVHVMSKAAGIEVARARRRYNCTGIFGETLAAALGTDGTHYHDKCWHHAAAHVLSPPLRPDPTTPEFMMKLLAHKLAAEQLSQAKRRGVVVYGETLASSLGCTMTNVRPQALVYYTTSPPIRKDPETPRHLLKFLALDDLQTTGSDNCTFNRNQKELGLKDFSKIPNGVNGVEDRMSVVWEKGVQTGLIDAQRFVAITSTNAAKIFNLYPRKGRIAPGSDADLVIWNPKAVRTISASTHHQACDFNIFEGMKCHGVPEFVIVRGRVCLENEHVRVAEGQGSFLETPVYPAFVYDALNGRVHTEEESDDKQARNGLQNLDLHHKPGYENDGHDPYPLPEKYIPGPALSVISGDSQVSTPHSILGHRPDGAKNMQESTFSISGKEKLSECPTSRFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0B0</accession>
    <name>A0A084W0B0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011598</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019110">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0B0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011598-RA">
        <property type="protein sequence ID" value="ASIC011598-PA"/>
        <property type="gene ID" value="ASIC011598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011598"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10412" checksum="C7386CF886AF31D3" modified="2014-10-29" version="1">MVAKASGTIFGVSSIDPVSSPRASENTNARLRMGTGSDAQPSGVSACIQATMAGSAKGHHSLKMGTANPVVRLPRIRTKRESPCYALQQTVQDAPVDACVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0H2</accession>
    <name>A0A084W0H2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001171-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011449</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0H2"/>
    <dbReference type="STRING" id="74873.A0A084W0H2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011449-RA">
        <property type="protein sequence ID" value="ASIC011449-PA"/>
        <property type="gene ID" value="ASIC011449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011449"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="21685" checksum="D077C7272EB03572" modified="2014-10-29" version="1">MNMTVNFILVVLYRAEHIYRQINVRAGKIMQDTKTPIEIVKLYLQHTDTTVTVHCIIRILSIPVLLLNLWYFFVIVFAVRLAAKCTTDHGVFYTYTSVVQDMRSGGNFNVVNPIAFLVSEAGQLYYVVEASQKFTESASSFIQSLSCSTNKIVDDMNDQAVELLTIEYLSRDYAVRIKGLYTIDNTMLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0X8</accession>
    <name>A0A084W0X8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP005976-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00011605</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0X8"/>
    <dbReference type="STRING" id="74873.A0A084W0X8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011605-RA">
        <property type="protein sequence ID" value="ASIC011605-PA"/>
        <property type="gene ID" value="ASIC011605"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011605"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015482"/>
    <dbReference type="OMA" id="XQNEGTI"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07653">
        <property type="entry name" value="F-BAR_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11619">
        <property type="entry name" value="HR1_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11911">
        <property type="entry name" value="SH3_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000203">
        <property type="entry name" value="Cdc42-interacting protein 4, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
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        <property type="entry name" value="F_BAR_dom"/>
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    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF12">
        <property type="entry name" value="CDC42-INTERACTING PROTEIN 4, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="16">
        <location>
            <begin position="344"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="531"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB43872.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011605-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="596" mass="67003" checksum="EC9261CB6A41F4ED" modified="2014-10-29" version="1">MRLDVDQFDNLATHTQKGIDFFERFGNFIRDRSAIEVEYALKLRRLVKNYQPKKSKEDEENEFSTLIAFKNVLKEVTDLAGQREVVAENLQTQVLQGILLLSKNLREERKKSLNQGALLTQSLHTQIGTLERAKRSYEKAFREAEKALEGYQKADADFHLSRADVEKQRVNMNIRNSQSEDAKSEYANQLQITNKLQQQHYQTALPEVFNRLQELDEKRTRGMKEFIKRSADVEYEVSPIIARCLEGMVKAADSINEKDDSMIVIEKYQSGFQPPGDIPFEDLSKPDPDAANNSQTHNSSTGLNHMTGKGTTKDKLKKRVGIFGIFTGNKNNLSTDGLKEDFSDLPPTQRRKKLTAKVQELQQKVAQEQAASDGLMKMKGVYEANSTLGDPRTVEEQLNESINRLDRLRIELQRYQKLLDQANSQTCNQHSPQANRVIQNGQRASRHSNGSSNHENNHDDNGEDHPDDAGSLSRSASESSVQQAQNGLNINNNGSASPESGLGTSHTSLPGSGQGSTNEQPLNDEYYDADQPLGTCRALYPFDATSEGSIPMSEGEELQVIEVDQGDGWTRVRRFSSKGWEEGFVPTSYIECTLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1J0</accession>
    <name>A0A084W1J0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011918</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019349">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1J0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011918-RA">
        <property type="protein sequence ID" value="ASIC011918-PA"/>
        <property type="gene ID" value="ASIC011918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011918"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11737" checksum="641112ED4B8CDEED" modified="2014-10-29" version="1">MACVGAAAGWCETRTATAHTEPRNRTPFLAGEEKRERTPHTPPASCCVAPVPHSLPCPLSLTRPGYGGLALYILQPLTPTKPLEEYPYYLSLTAFVAFVVVVKLKAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Q6</accession>
    <name>A0A084W1Q6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP003522-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011988</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019405">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W1Q6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011988-RA">
        <property type="protein sequence ID" value="ASIC011988-PA"/>
        <property type="gene ID" value="ASIC011988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011988"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014790"/>
    <dbReference type="OMA" id="FFTKGFE"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="704" mass="79978" checksum="49C930E71D3CFBCB" modified="2014-10-29" version="1">MNQEDLYWFTFILVTLLGFYTYKLLTRNRSYFRVLRVPHEKPHFMYGNLSDVLSGKLTTMEKLAQYYQKFSTHGFFGFFNYMTPALYLRDPKLIRQVLQQNMDHFGSHGYFLDENKDRFLGSQLHLVKNTEKATQLSYFLLPLFNCSTTLGGMEGVVKKNCKALVDFISSRADLELEVKAICLKHLLNLFAGCSFGKEINAFEDDSDRFCTIASGMAYGTNPMQVLKTIAFYVAPGLMRSMNVQFSDPQEIEYLVKQFQTAASTANGHSMPRVLAKANEKLANPQEQLNDEQLTAHCATFFTKGFEPTLNLLSFAIYELAQNQQVQSKLYDEIKTIVKETLRKWPPHPLLVRECTKPFTIPASENGDRAAIPLKVGDKVYLSVWALQRNEEYYPEPEQFRPERCFGEDGTNAPANTFIPFGIGRGCLGQEFVKMVVKASLVSIVQRFKLTPGERTSEPLKLIETGSSVEARDEYKXXXXXXXANPQEQLNDEQLTAHCATFFTKGFEPTLNLLSFAIYELAQNQQVQSKLYDEIKSKASSGDISVDFICSLPYLEAIVKETLRKWPPHPLLVRECTKPFTIPASENGDRAAIPLKVGDKVYLSVWALQRNEEYYPEPEQFRPERCFGEDGTNAPANTFIPFGIGRGCLGQEFVKMVVKASLVSIVQRFNLTPGERTSEPLKLIETGSSVEARDGLWIRLEPRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W208</accession>
    <name>A0A084W208_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009876-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W208"/>
    <dbReference type="STRING" id="74873.A0A084W208"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012147-RA">
        <property type="protein sequence ID" value="ASIC012147-PA"/>
        <property type="gene ID" value="ASIC012147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012147"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002308"/>
    <dbReference type="OrthoDB" id="6372059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012147-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8238" checksum="DD31C2504914BF79" modified="2014-10-29" version="1">MASDHLLAYLSVAQGEYSYTAPDGQLIRVQYIADENGFQPLGDHLPTPPPIPPAIQRALEYLATLPPSDDASRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W284</accession>
    <name>A0A084W284_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012227</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W284"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012227-RA">
        <property type="protein sequence ID" value="ASIC012227-PA"/>
        <property type="gene ID" value="ASIC012227"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012227"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012227-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="16038" checksum="85092A96932FBB7F" modified="2014-10-29" version="1">MHRRWAVANGRPVCPFRCTLGAECLGALAEAIAFRILANGERCWRAMAKREDISNRAEVIQETIPKAAPNTSCPRVVGFSELTLIKSNTLADRVVPVPVCSAPFRPSCSERQAKPQQPITKPCEESLTYVDGIKNKIDVVFASRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W318</accession>
    <name>A0A084W318_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002767-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00012495</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W318"/>
    <dbReference type="STRING" id="74873.A0A084W318"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012495-RA">
        <property type="protein sequence ID" value="ASIC012495-PA"/>
        <property type="gene ID" value="ASIC012495"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012495"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018579"/>
    <dbReference type="OMA" id="LYMWFLT"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="39"/>
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        </location>
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        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012495-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="291" mass="34322" checksum="5F9EBBF5DD2A2B6B" modified="2014-10-29" version="1">MDFYEPVPLALAYGNGSREWFVERWNTLLDTIGDDIDTLYVWFLTAYTYGFFWLVGGLFVLMDLTNKPRFLRKFKNQPGANEPLQWDRFVNLVKTIAYNQLVFGVPTSYLSYHARKFIGADIPDPRVLPSPYIIVRDVMVCIVAWEITFYYSHRLLHSTFFYKHIHKKHHEWKAPVAWSAMYAHPFEFIISDLLPVYVGPAIMTSHVFTIVVWFTFVMMDTLVDHSGYHLPVLGSSEMHDYHHLKFNQCYGLFGWLDGLHGTDSEFRKKKQYQRHHRIFALKSARELVPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W381</accession>
    <name>A0A084W381_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP013081-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ZHAS_00012581</name>
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    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084W381"/>
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        <property type="protein sequence ID" value="ASIC012581-PA"/>
        <property type="gene ID" value="ASIC012581"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012581"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015651"/>
    <dbReference type="OMA" id="TPNIHDF"/>
    <dbReference type="OrthoDB" id="7482953at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="1518"/>
        </location>
    </feature>
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            <begin position="173"/>
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        </location>
    </feature>
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            <begin position="240"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W390</accession>
    <name>A0A084W390_ANOSI</name>
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        <submittedName>
            <fullName evidence="1">AGAP004113-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00012570</name>
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    <organism evidence="2 3">
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        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Diptera</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="8355" checksum="408FB8A66EF09F07" modified="2014-10-29" version="1">MMVLPNGATININYHEPRRIIKLPLDLSLLSEAERKARIEKRKPKQKIRIEDDVEDTFNANKYLKYMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4D3</accession>
    <name>A0A084W4D3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011987-PA-like protein</fullName>
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    <organism evidence="1">
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        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020317">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W4D3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013048-RA">
        <property type="protein sequence ID" value="ASIC013048-PA"/>
        <property type="gene ID" value="ASIC013048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013048"/>
    <dbReference type="OrthoDB" id="6262731at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11561" checksum="C881E85EDA04A588" modified="2014-10-29" version="1">MLNGGDILPNVSSALGGKDGHHQHREVVARWRVPMYGKVYEIEFEHGTASGKRVLWIDKQEVFRRDWMFKLVGEDMFKLEDKRCIIRVXXXXXXXVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4I6</accession>
    <name>A0A084W4I6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013152</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020335">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4I6"/>
    <dbReference type="STRING" id="74873.A0A084W4I6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013152-RA">
        <property type="protein sequence ID" value="ASIC013152-PA"/>
        <property type="gene ID" value="ASIC013152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013152"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="15104" checksum="F7B7AF4711B5F584" modified="2014-10-29" version="1">MNPAPMGYGKIIMQRTNYNKLRSGTVRQIGTFAYHLLKGKKKKLRSGGVNMQVYINSSGPITKSILQQYDDDVESSYFRRKPTSFLSNSSGASGGGGGGGTGPGSGGAGLIIGSSATLPAGDSKRYGGSWLPAEDEAVRLEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4K6</accession>
    <name>A0A084W4K6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00013105</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="ATLV01020345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4K6"/>
    <dbReference type="STRING" id="74873.A0A084W4K6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013105-RA">
        <property type="protein sequence ID" value="ASIC013105-PA"/>
        <property type="gene ID" value="ASIC013105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013105"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008994"/>
    <dbReference type="OMA" id="TDEHLCL"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF118">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="17">
        <location>
            <begin position="147"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="519"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="664" mass="77086" checksum="D27E6F111A641824" modified="2014-10-29" version="1">MMFRLRVKIFYVYIIISCVFSVYLFYLISKYSFEKIMKYHRHARSNKFPDRPRIPQIVGHYVGVGSVGNLSKDFMNSNNFDPIPGVGENGDPVVIQAKDLLRMQQLFQINRYNLLASDRIALNRSLPDVRKPKCVSKQYPSKLPTTSVIIVFHNEAWSVLLRTVWSVINRSPRGLVREILLVDDASDRRFLKHELDSYVQRLPISVTILRLSQREGLVAARLLGARMASGDTLTFLDAHCECSPGWLEPLLARVQANPKKVVCPVIDIISDDNFSYIKSFEFHWGAFNWPLHFRWYTLSDEELTERRKDTSTPFRTPAMAGGLFTIDRKYFFDIGAYDERLKIWGGDNLEMSFRVWQCGGEVEIAPCSHVGHLFRKSSPYTFPGGVSGILNENLARVALVWMDDWAKFFFKFNKGTEEFKNLNVSDRIALKRSLNCKSFDWYLRHVWPQNFFPAPNKFFGRIQPIDLTTNFDYQEYLTLMKKINLIVKNLNPELKWKFLIKYLTENVKRIGDSMKAAKHSPYCLHKPKTNPAINQPYGQSYLHKCSLLINTLDEQFVIDDYGRIMTDEGICLDSYRKTSIDGEELVEGVRKIKMVTCGSQKPNQRWVYETDTYHLKNIGDGAECLERSATLVRDEGEDKYELFLGPCDVRNELQKWMLFPVAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4L6</accession>
    <name>A0A084W4L6_ANOSI</name>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4L6"/>
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        <property type="protein sequence ID" value="ASIC013116-PA"/>
        <property type="gene ID" value="ASIC013116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013116"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14037" checksum="338C1A7F7DD4A818" modified="2014-10-29" version="1">MRLIDSCQCTPSVDSADGCPPLTNDTETFGRSTAVRYVNSPCASFPPARRYGHSTVARRRSSASKSVLFRPLPSSSQKKSAKNRITPFCPSNESEVRDTDDTHLRPKKAKPPTCAPAASKPAAGWSKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="gene ID" value="ASIC014481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014481"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KFB46492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14014" checksum="88B5AA39796C6F25" modified="2014-10-29" version="1">MAEGVKQFSAADEMPMKAACVAENGKKEPPTPHTFTDNTVINEPERRVSIAWEIVDHLCRNSILSATLTTVSAASILKLILQTVGYGKGGPWRLGNYHHPFYIKLAEKYTYHAWLNEALYPCECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8J8</accession>
    <name>A0A084W8J8_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">CxxC-x17-CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014645</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC014645-PA"/>
        <property type="gene ID" value="ASIC014645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014645"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759970" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014645-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="12994" checksum="D52E5BA62E870B94" modified="2014-10-29" version="1">MFPLVTTALLLSGSGFGILAQLVPLLSEHTVDSEAGHLAQLVDGIERICPERRSSSILVLFYVAGDVTAEHALVALSQRYPIMVQNSNFSGVKQPWFTKCIVGFFSTAESFKVCNRYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8L6</accession>
    <name>A0A084W8L6_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00014596</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8L6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014596-RA">
        <property type="protein sequence ID" value="ASIC014596-PA"/>
        <property type="gene ID" value="ASIC014596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014596"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014596-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7238" checksum="03B55EC4392FED3D" modified="2014-10-29" version="1">MTAKQDIHPQPVAWLRSLGEKERPKAIEKQKKKKKHEEATLMNVASKPARLVVVPLAFLFIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8R2</accession>
    <name>A0A084W8R2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014647</name>
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    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8R2"/>
    <dbReference type="STRING" id="74873.A0A084W8R2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014647-RA">
        <property type="protein sequence ID" value="ASIC014647-PA"/>
        <property type="gene ID" value="ASIC014647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014647"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012485"/>
    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
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        <property type="term" value="C:intracellular organelle lumen"/>
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        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="term" value="P:aggrephagy"/>
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        <property type="term" value="P:endosome organization"/>
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        <property type="term" value="P:mitophagy"/>
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        <property type="entry name" value="Next to BRCA1 gene 1 protein"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="44"/>
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        </location>
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        <location>
            <begin position="640"/>
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            <begin position="187"/>
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            <begin position="265"/>
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            <begin position="336"/>
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            <begin position="398"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74704" checksum="9B03B89EBF3482CE" modified="2014-10-29" version="1">MLAEDNEKGRLYVEGKEMTEVAASPPQVQSVPEPPVADGSRPQHVHVVCDVCDRMIVGHRYRCLMCHDYDLCMTCESKYRHKDHIMLRIPRATDTRQSHQVLAKMEFYAGQLKLEEENPSQVPLVDDGKREERTNPQGHSKFYQNSFMGRRNCAMRTANAAAAAMVQDRAQARFREVLSRYIDPANISGPAASSSSSTSVKANAPSPSTTVHDELLTEAQRSMKIASDAAKVASAAATASWNTFMGCAGMFVPPGTQNTTPKQPSPTGTGATTPSSSNGSVVAGLVDGVLKHTPPELKEFIPTEDEINRLSEKLSSMLSSLGIEFTGESSTSSCSARKETEQKTPEQEKDSLPSSMNSGKEEKQEQVAAAVNLPEVSAEGKQPLLETDNVVASSSQDDDGKLTVEEKGQTTENIDCSADTSSASMLTDDDEDVVEAAQVSEQNTSPQASSNQRKVPWILVDLPDDHEEEVKQAVANTTSSVPVASSTPSSSPEKVDDKQTPEETSPKEQPEVEEFYANTFKTMIDLVKQLTVDPNGAEQKVSEMIERSQKEMNKHAQDDRYKAHLEKAAKELQKHLLEVKMRERIERQTEALQQSAKDKKSVAQASTSARVLSPTTSPLPSTSASPKPPNASNTIYSPRPHVNQAIHTMMTMGFSNNDGHLTRLLEALDGDIQRALDMLMQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8T5</accession>
    <name>A0A084W8T5_ANOSI</name>
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        <recommendedName>
            <fullName evidence="6">Transmembrane protein 268</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014676</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021514">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084W8T5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014676-RA">
        <property type="protein sequence ID" value="ASIC014676-PA"/>
        <property type="gene ID" value="ASIC014676"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS018368"/>
    <dbReference type="OMA" id="CCGVNCM"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028054">
        <property type="entry name" value="DUF4481"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN C9ORF91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14800">
        <property type="entry name" value="DUF4481"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61190" checksum="E54F604DC3A9649B" modified="2014-10-29" version="1">MLFGSLHPSACATSHQRSSSTAVAGARGGLRVCLARVDGTLFPKGNEANGSAEITVESARKMEPSAKGNSNGNGGDVGETSDRSASPASLRQNNATGMGTSSTVSNGTPSVPIVGDGLKTSSNWVKFEEDGEPATSPSSSLPPPPATGKHHPGAGSSRQSTTTSPDTAPPAVLPTETVHVHLDTRSPSTPKQPQSQNLPQSTTSPAASTSKPSGKIGGPASAGQGAPVTSGLSKTSQPAVIDIPKQSVNVVQPIQSMRTIELSTGRVREGFANGDVIVTLLPTNTRWPWITPAVFRPELVPEELMAQGLTLTVEEYVHAMETLVNDYRFTLYNICYKRVLVVWILFAFFVLIGLLFSGIYGITLFSLGVAWLFLNAAAIFLCMWVKLKLARGLERCMARVNKQLIRHKILLALDDRGHISCHKVNLCFLYFEPSQCISYLNEFIERSEQNGNTIEPGWEGRLDVTTNDIVIQGANTTRLSRKQGRAEGIFLRYLQRWGKDYLRRRLDWTIEENAIVSAPRHLPTAYCPCQYAEEVLLQKKPKEDPRLCCATLRQLMARVGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W995</accession>
    <name>A0A084W995_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010990-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W995"/>
    <dbReference type="STRING" id="74873.A0A084W995"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014793-RA">
        <property type="protein sequence ID" value="ASIC014793-PA"/>
        <property type="gene ID" value="ASIC014793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014793"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005568"/>
    <dbReference type="OMA" id="GKYHQMM"/>
    <dbReference type="OrthoDB" id="6664669at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784720" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="20319" checksum="D51819289938CC7D" modified="2014-10-29" version="1">MLLGNWIVLVVGLSCAMLVDASVRITNYTDEWDPKYLDVDLRVRRLDKTTSIDFDLDLKQELDKNVEYDVRLCKRTAGKYHQMMYTGKQQLCGKDLRRSRNLLDRYIASELVKHSNLTTRCPIRTGHYEVRNFEIDDRHLMMSVVPSGEFLIEVGVYHRGKEIKMNRWFVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA88</accession>
    <name>A0A084WA88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP005934-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00015182</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA88"/>
    <dbReference type="STRING" id="74873.A0A084WA88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015182-RA">
        <property type="protein sequence ID" value="ASIC015182-PA"/>
        <property type="gene ID" value="ASIC015182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015182"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015312"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="243"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB47132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015182-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="391" mass="44032" checksum="B385A7C212C4F891" modified="2014-10-29" version="1">MHKVDENALGRMLSSYRDPTCTKKDVLNVLRIYHGLQHRVEEYVFNDGSTKHLLNLNGTIPVKFKGNTYNIPICVWLMDTHPRNAPMCYVKPTPEMRIKVSAYVDFNGKIYLPYLHEWNPKSDLLDLIQIMSVTFGETPPVYSKGPETNYTPQPYVPPTSATSYMPPYPTQQFPQYPMPGAGYNNFVPPSSGPAGAMPGYGMPTYGMPAYPPVPGALGGAGTGTITEEHIRASLISAVEDKLKRRVQEKVNQCQAEMQTLKRTQQELTEGQSKIKEIMSRLERDEKELLKSISLLKDKEKELQRSLDLVSTVDSIDVDEAVTTTAPLYKQLLNAYAEEAAIEDATYFMGEALRGGVIDLEVFLKQVRQLSRKQFMLRALMQKCRQTARLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBX7</accession>
    <name>A0A084WBX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP009127-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015786</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBX7"/>
    <dbReference type="STRING" id="74873.A0A084WBX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015786-RA">
        <property type="protein sequence ID" value="ASIC015786-PA"/>
        <property type="gene ID" value="ASIC015786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016622"/>
    <dbReference type="OMA" id="DPPVEWW"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF225">
        <property type="entry name" value="MALTASE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="198"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="642" mass="70605" checksum="FD516FAEDA2FC6B2" modified="2014-10-29" version="1">MNHLQISTDPTLLGADLLPESLTTSPSVSTFLPEEDASTCLLLPETPSPPLDFSHPLTPSMGNPGDNLPHDSVTGGDDPAAETSSSSGSSGIGMVGPVGAAAGNLFSHNTYQHLRKKSDVAKAGQDGSMHHAAILGIAVTKDMPGFVHWNWPLIRKCTFFAFLAVIVAMVGIVVAMIATLPKFCNPDTAWYKGSVFYEVFPASFQDTNEDGLGDIRGLIGRAEYFKSLGIGAVRLNSIFPSKHYPDHFQEITTLTDVDEVLGKVEDIQKLAATLHERNISLVLDLPIYPFLDRLSPSTIDLDRLPNRTDGDMVTSEFLRLSRSVEARSEGTIVSDVVRFWLTRTGVDGFYVKGLEHFAEDPLLVENVKEWKYLLGPERVLIVGQKLVEKLPASVVHDVLSQVDLVDVYLDVSNGTDGIGKTVQDAIQGRLLRGEDHPWIHWSLGSVSERRMTSGLSPNATLAATLMELTLPGTPSIFYGDEISLEEVHDPKGEHGDSQHLHHLATMVWDGSQNQFTSRASLPWIPRSASASLHHLDYVIEAIALRKRSPSIYLNAVVKEGKRLPNADVKSNQNEILVVQRWYPRRNSFATIANLGQKRVSLDLTAMFYSGEIVAGSSLKHERVYFDHFEINPLETIVVKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCB7</accession>
    <name>A0A084WCB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP012416-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCB7"/>
    <dbReference type="STRING" id="74873.A0A084WCB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015914-RA">
        <property type="protein sequence ID" value="ASIC015914-PA"/>
        <property type="gene ID" value="ASIC015914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015914"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016715"/>
    <dbReference type="OMA" id="WRHERTE"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12254" checksum="8BA6488761A6FD79" modified="2014-10-29" version="1">MPAELKPSFKRVKPANNTQGKVKISRTVEDIDARLNALERKESSGERMEMVKKEKSDSEDEKDREDQEEEVPDDEMDDDNDYGNNYFDNGEAYNDEDDNLDDGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCD2</accession>
    <name>A0A084WCD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003434-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WCD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015931-RA">
        <property type="protein sequence ID" value="ASIC015931-PA"/>
        <property type="gene ID" value="ASIC015931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015931"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004360"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="288" mass="33524" checksum="1635EEAA3E9EBD90" modified="2014-10-29" version="1">MDLPTSKEHEDSNIFDFERLDTPKQLVEFEEKLGKDAAFADYMLSLAELKAQYEEEDKQLQELRNQLVEQDTKMKAVEEEWEEIVVQMYPSVTELFAKEPEDIESATDDDVKQLSERVVSLLKEEKYPELVRLVQRADFALGNRDERQEMTFEHQCMYYIMLLKNYYVHSHVDNTLNEEFQKKENSVNFLHDSIRFSELISNAVPKLLEMLMSKAQTDVHGAIDFFTSAYLFGIKGTEQGMQQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCI9</accession>
    <name>A0A084WCI9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00015995</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WCI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015995-RA">
        <property type="protein sequence ID" value="ASIC015995-PA"/>
        <property type="gene ID" value="ASIC015995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015995"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006558"/>
    <dbReference type="OMA" id="IMKQYNV"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057042">
        <property type="entry name" value="Beta-prop_SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24017">
        <property type="entry name" value="Beta-prop_SCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 20" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="23">
        <location>
            <begin position="434"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="960"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="20">
        <location>
            <begin position="1370"/>
            <end position="1409"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1116"/>
            <end position="1194"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
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            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="72"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
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            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="1118"/>
            <end position="1133"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1148"/>
            <end position="1166"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB47933.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1492" mass="165024" checksum="1C91D8C6CAD16B2C" modified="2014-10-29" version="1">MTASGSVESLFPSTPEQQHNNHNHHHNHHQHPTASTTTTSTSQQPVRRSQPLNSLSSPKLSTMSGGFSQQHPSLMVGSQKPPRSSGGGPPVAAGTGGGGRTGAKQSDRRSASTTLPSRVSQMYYKHGLFLSSYPTTATSIALAIIIFCCYPLLNIPLPGTIPTKVIFPHTESISENLHLSNANLSSEFYNPFSFSGGNMFNIYNISMETPFPWARIDPLLYVQQVIMRTSVVPWEDDLLLTDAFRGPLYEVFKLVEIIRNHEDKSKITLGHLCLHVENVKRSSQQTLFPEYNCLLLSPANLWQQNMQNFNKDSNLLNTIFVNHNLQKSKVSNAEMLFGIPLRDTGVKRYPMRTRPRIIQYAVTLILRENNPAYIESLRAKLVRAYPLHQKNVAGPEDATDGDGEAATETNAKEQPIGQQSIMYIFYPGEFNWKEVLPQCVAFVLLFIYVYFSVRKIEAIRSRLMLASCAVLTVLGSLMMSLGLCFFFGLTISFQSKGVYPYLVILVGLENVLVITKSILTTDNNLDVKIRVAQGLSREGWSITKNLLTEITILTGGLATFVPVIQEFCIFAMVGLVSDFLLQMLFFATVLALDIKRVEYSTEVRRLPKMLYYNSEFRRGAGNVTVSGSTLETRNGAVGSINRSRSHPKLTGLDQAAGHQKSAASLSGGTGSGKDAKIPKRLRIVNFWARTRFFQRGFMIWMVLWISNIIYNAGLIEELFVIDKNLTAYGDMSSVALDSSVTRFELPPGSHEPHEVSSESVSALEMDRLNFQKLPDGLPAGGGATPALNVTEQLNRLKHPDYETVYQLSNFHWSSILKQYNVSLSGRYVTVLPPIKLSHAVSPQTALQLRNVDEKAPHHFQWKALAVALDPLDFNDADTGDGSPVPIGNAPFYPKTPMEILLTCMLLAVSTFVLTYTMIVLYRCVCTRNYAEWRASWHESDSETDVNRPEQCLLEGVPIQVNGHAHRIECLVTDGNMIASSCLQGQVKIWDVTNGEQMAEIDRWRYFEMQQRRGSTASPQTQPPSPSDTTSVGVLLRNDEANSITGMQEAFLAATDNNSASSASSPPAGASFKLKKKLHFNFSNTPDTSADGKIASDSKLFDFQTQYERFFTPCPAVQRSVSNDNSSPVSTTGGSDLRNRFAPNGSHLVGTTNGAATASSSEQNNHWQARPTVLSNECPRPPGPPSPKQQQQQQHQHQVSPIWCLDFLDNLIVIGCADGRLEFWEGSSGNFKCIYEAENSHNNGVTNIKLTGDRVIAARLSGRIDFFRLETYTQGRQIDWGFTSAYRRSMYSGGVTCLEVAGNTVMTGSQDHTLKVFRVDNHQLLYTLHSHCGPITCLFIDHWQSGMAGSGSQDGLLCVWDLTTGACMYKIQAHDDSIVALAGSPSYVISLGLDERIRVWDRFQGHPLNTITVSHAYSALVMLTPSLLVTGKPGALVVWDARSGEVAREVKLDCSNMQLCPKIMLPACGSVICDYGNQMRVVRFPLVAADKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCQ9</accession>
    <name>A0A084WCQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005063-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016117</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022832">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC016117-PA"/>
        <property type="gene ID" value="ASIC016117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016117"/>
    <dbReference type="OMA" id="YGQQLRM"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000011">
        <property type="entry name" value="RAN binding protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="54"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="638" mass="69410" checksum="503271B371CEA670" modified="2014-10-29" version="1">MADNAPAAAASSVKCSDGGRPFDSSLKSLRKMFNPNNVQSGSGGAAGGAAGGSNAAATAGPVDRLKILYPNVNEAVDPLPRSWSLQDKCSTIGLTQNNLRVHYKGIGKSHTDAASVRTAFPIPAACGLYYFEVKIISKGRDGYMGIGLTHTNFKMNRLPGWDKQSYGYHGDDGNSFCSSGNGQPYGPTFTTGDIIGCGVNLVDNTCFYTKNGHHLGIAFRDLPPRLYPTVGLQTPGEVVDANFGQEPFKFDIEDMLKELRAGTRATIYNFPLPDDQGDWTVILHKMVSSYLVHHGYSSTAETFARTTGQALQEDMTSIKNRQKIIKLVLSGRMGQAIEQTIRLYPGLLESNQNLLFMLKCRQFIEMVNGSDFDLGTPSSRTSPVQTSVIQSTKSYQNGNTILPEAAGDNQGYLKNNVLSNNTTNNNGNCIEDDYSNDVEMENGHSNSGPTNGYKNGGPPAVNRTTNPHESVEEVEDEEEEEEDDDEDGHDAGRDEDMDVDSSLSPNCKSANAAAATTKSGVERMLEFGRELFQMSQRLEKEHGVNETNQKMLEDAFSLLAYSNPWASPLGWQLCPSRREAVCAALNSAILQSMNYSWRPPLEVCIAHACELLRLMSSSSLGACAFVSVEDILAQHQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCS0</accession>
    <name>A0A084WCS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016131</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016131-RA">
        <property type="protein sequence ID" value="ASIC016131-PA"/>
        <property type="gene ID" value="ASIC016131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016131"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016131-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9237" checksum="9DDB07E0826C8D0E" modified="2014-10-29" version="1">MAKGVAHGVPRLLALGEWRFGPGASLDESSVTFYDPPRSRKPNNHGGAHTVELLNHGPFSKDLHRLISSSVGRTILVPGPAGDCRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDV8</accession>
    <name>A0A084WDV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004996-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016526</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDV8"/>
    <dbReference type="STRING" id="74873.A0A084WDV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016526-RA">
        <property type="protein sequence ID" value="ASIC016526-PA"/>
        <property type="gene ID" value="ASIC016526"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016526"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015371"/>
    <dbReference type="OMA" id="CTIDNTA"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784644" evidence="3">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="67"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="317" mass="34591" checksum="74A78B556DA29BF3" modified="2014-10-29" version="1">MRTFFLVLTLALALIETLANGTAATGKSINDQLSLASANSIRELTVNQQSLMSKTTESILEGRQGEPEGDIINTSCDDPRITETGTYLVQDSFDVPTKLICVLEFGPGAYTVIQNRQDGSTDFYRGYNDYKAGFGEFDGGDYWLGLDRIHNITASGDYELFVLLEDFEKNVSFARYDSFSIGSSSDFYPILKLEGFSGPAGNSFDVVGGVLFSTYDLDLDNSEINCAVNNRGGWWYTECGDSNLNGLYLKGLTGGTTGMSWRTFRGPNYSLKKSRMMVKRKGPLKPSSTLQPDPTDGPVTEPATTLPPTDTTASVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE66</accession>
    <name>A0A084WE66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016744</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023169">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016744-RA">
        <property type="protein sequence ID" value="ASIC016744-PA"/>
        <property type="gene ID" value="ASIC016744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016744"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16598" checksum="0AA0EDA6999E0E16" modified="2014-10-29" version="1">MLQDSNNSPLYTRISSALSSPHEGEGGGKTFASGHSDWSFRSTCHCLAMVHEMNSPSRRQHFYIECLPLDSMALKCRQGRVGPRLGLSLPLFPRACLVQRSPPPDECPLGHLSMSMVDVFQQDSHHIYAPARRVCCAPCHVVSLAGVAPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEK4</accession>
    <name>A0A084WEK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Protein kinase C inhibitor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016641</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023220">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEK4"/>
    <dbReference type="STRING" id="74873.A0A084WEK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016641-RA">
        <property type="protein sequence ID" value="ASIC016641-PA"/>
        <property type="gene ID" value="ASIC016641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016641"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019075"/>
    <dbReference type="OMA" id="LAFMDVM"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14644" checksum="416E33AD76628F63" modified="2014-10-29" version="1">MSDEVAKAQAADSAAEDTIFGKILRKEIPCNFIYEDDKIESLSVRRFQRCESAGPVHFLVIPRKTIPQLSKASEEDEALLGHLMVVGKKVAAEQGLEEGFRVVINDGKNGAQSVYHLHLHFLGGRQMKWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WES1</accession>
    <name>A0A084WES1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00016717</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="ATLV01023246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WES1"/>
    <dbReference type="STRING" id="74873.A0A084WES1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016717-RA">
        <property type="protein sequence ID" value="ASIC016717-PA"/>
        <property type="gene ID" value="ASIC016717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016717"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020254"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="183"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="302"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="375"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="503"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB48715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="550" mass="60825" checksum="A420BF72D6E0A592" modified="2014-10-29" version="1">MSVNLRSVFAFAKEYHQKKESQKDIQYGTAGFRSHADNLDYVMYRMGVLAALRSRAKASQAIGVMITASHNPEHDNGVKLIDPLGEMLEQRWEKLATDLVNVPDGELEAEVARICEQEKIDNNEQAKVFVGMDTRYHSPQLSRAVVNGVLALKGTVTEFGIVTTPMLHYFVTCTNTQNAYGLPTEEGYMNKLITAFKTLRGDSTENGNYKNQLFYDGANGVGSLKMLGFIKKLNGSLNVKVFNSNGKINFKCGADFVKTNHRVPEALPEDALPNGRCVSVDGDADRVVYYFTDSDGVFHLLDGDRIATLLAGYLKDLIEKCGVKLEMGLVQTAYANGASTDYIVNQMKIPVSCTRTGVKHLHHKALDYDIGVYFEANGHGTIIYSNKAKDLIRAASKDESLSEEQRETAKRLLQIVDLTNETVGDAISDLLLVETVLHAKGWSLNDWLASYTDLPNLLEKVYLADRNVITVTDADRVVVTPEGLQDSINEIVAKFPKGRSFVRPSGTEDIVRVYAEADTRANAVQLAYEVANLVFDRAGGVGKRPEKMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFK7</accession>
    <name>A0A084WFK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000108-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFK7"/>
    <dbReference type="STRING" id="74873.A0A084WFK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017007-RA">
        <property type="protein sequence ID" value="ASIC017007-PA"/>
        <property type="gene ID" value="ASIC017007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017007"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001712"/>
    <dbReference type="OMA" id="YIYWSLA"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010850">
        <property type="entry name" value="Neuroparsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07327">
        <property type="entry name" value="Neuroparsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784965" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="15550" checksum="3AF9CD7395E30D6B" modified="2014-10-29" version="1">MSSGSVLLLTVLLIGYIYWSLAQPTNIFEIRCKLKKPVKDAHIVCPHGVFIDPCGMEECIRGPGDLCGNTKYDIVLYGQCDHDLLCCNSRCRGCTAQGVCFDEPCHPPKQHGMQHRSDPYMPLRNPNPLYALLDYYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG89</accession>
    <name>A0A084WG89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017239-RA">
        <property type="protein sequence ID" value="ASIC017239-PA"/>
        <property type="gene ID" value="ASIC017239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017239"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14044" checksum="8EAEFCE387E90345" modified="2014-10-29" version="1">MLPGCDTTARDKFMTPAHVRAARINHHDKRPPNRFRWLRFDILFATVGKTVRSGGAIGTPQDAFSRAFGSQKPKTVDPNFPPDPQKKSCPFDVWRPKIGSLILDPHRSLDTESLEEVPWQGVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIB5</accession>
    <name>A0A084WIB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017996</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017996-RA">
        <property type="protein sequence ID" value="ASIC017996-PA"/>
        <property type="gene ID" value="ASIC017996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017996"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="11949" checksum="6BFBF76C221EE8C7" modified="2014-10-29" version="1">MTVGLEGKGRARRLAVATTVAVRFRHIISQHQATTATRFAHIQSTCFFSTKPGRFFLPRVGSRFAGSNDDGTPVLEPPIPPNANANECCKKDGDVQQESSSNSSSRQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIV2</accession>
    <name>A0A084WIV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018207</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018207-RA">
        <property type="protein sequence ID" value="ASIC018207-PA"/>
        <property type="gene ID" value="ASIC018207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018207"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5633" checksum="F365907E224A2B07" modified="2014-10-29" version="1">MKKEASSLCLALQRNYSCPFPHTGSSTSVCPVLVSSSRLNPLDSAVPAQARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIV6</accession>
    <name>A0A084WIV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP012390-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018211</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIV6"/>
    <dbReference type="STRING" id="74873.A0A084WIV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018211-RA">
        <property type="protein sequence ID" value="ASIC018211-PA"/>
        <property type="gene ID" value="ASIC018211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018211"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021078"/>
    <dbReference type="OMA" id="MIFSSHA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF85">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="13491" checksum="5B7E4CAAFD18DFF2" modified="2014-10-29" version="1">MVSCRYKWLDKTFPGTAKRIIIKKLLLDQFILTPPLLVIFFTGMSLMERQSSVIDECRQKFVPTFARSCLFWLPAQTLNFVLVPPKFRVVYVGSCAFAWVNILCWVKRQRLDNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ30</accession>
    <name>A0A084WJ30_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00018295</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 20">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023968">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ30"/>
    <dbReference type="SMR" id="A0A084WJ30"/>
    <dbReference type="STRING" id="74873.A0A084WJ30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018295-RA">
        <property type="protein sequence ID" value="ASIC018295-PA"/>
        <property type="gene ID" value="ASIC018295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018295"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012895"/>
    <dbReference type="OMA" id="QMASHTE"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000037">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="19">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB50224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="763" mass="84440" checksum="905C832853A3648E" modified="2014-10-29" version="1">MALSRIYTAKLACATNKNVLPAIATFVRNASDSTDLKAILTEKVPKEQERIKNFRKQHGGTKVGEVTVDMMYGGMRGIKGLVCETSVLDPDEGIRFRGLSIPECQQVLPKAPGGQEPLPEGLFWLLITGDVPSKAQVDALSREWANRAALPSHVVTMLNNMPATLHPMSQLSCAVTALNHESKFAKAYSEGVHKSKYWEYVYEDSMDLIAKLPVIAATIYRNTYRDGKGIGAIDPKKDWSANFTKMLGYEDEKFTELMRLYLTIHSDHEGGNVSAHTVHLVGSALSDPYLSFAAGMNGLAGPLHGLANQEVLVWLQKLRKELGDNASEDKVKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFGLVSNIYKVVPPILTELGKVKNPWPNVDAHSGVLLQYYGLKEMNYYTVLFGVSRALGVLASLVWDRALGLPIERPKSMSTDGLIKAVGANPAAGNLQMASHTEKVLQWINELSNPETRETALLELSKKRETVSDLAPMLWHSFGTTAALLQEIINIYPSINPATLTAHQSNRVCNALALLQCVASHPETRSAFLSAHIPLFLYPFLHTTSKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDSGLSYICHTYDRFSHVAIILGKMVISLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLRDGTFSACLQEDKSTKHWLTLLLKNLDTVPGPGGDPRQVGIQPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKX0</accession>
    <name>A0A084WKX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004903-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019208</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKX0"/>
    <dbReference type="STRING" id="74873.A0A084WKX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019208-RA">
        <property type="protein sequence ID" value="ASIC019208-PA"/>
        <property type="gene ID" value="ASIC019208"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019208"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009052"/>
    <dbReference type="OMA" id="DFVHLMG"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019208-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="242" mass="26901" checksum="FF218D7C7AEE556A" modified="2014-10-29" version="1">MHSIKLVLPRCLAVAQSSSLIRSTVHPISKHRLCSIFPGPTRTASAIRTLCSKPPVAGTVSDYAQQNKKEPDEASKVYYGTLTPQIRAVKVFSLATSIGGIVAQPILLEQASKIGGMPMIVAVCGFAGFFTFVTPILLHLVTKRYVTELHYDPAKQQYTATTITFFLQREKTNFKIEDVTVPEVGGLFTTFLVRDKAMFVDPQLFPDPTHYIKIMGYDKPINFKFEEARQTASSENPSKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL44</accession>
    <name>A0A084WL44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006184-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018977-RA">
        <property type="protein sequence ID" value="ASIC018977-PA"/>
        <property type="gene ID" value="ASIC018977"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018977"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021743"/>
    <dbReference type="OMA" id="SSYKHHE"/>
    <dbReference type="OrthoDB" id="6372047at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41156">
        <property type="entry name" value="AGAP006184-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41156:SF1">
        <property type="entry name" value="ZASP-LIKE MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018977-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="509" mass="55462" checksum="003FA0589AA1BFFB" modified="2014-10-29" version="1">MESILDCCKYTPNEPGTKVIKTTTTYTTAGGGGGGKPVNRELVFDSPNSYEVRQSRSRHRSPSYENQSTTVKNVSYSSDSSAGIYGGINRSATPQRSMTPARSEEYYTETRTVSPNSDLLPARNVRYNESVHVDSAANVLQNIPLSDDILPRPNTKVTTTVRTYTYELPPDGTGSLNQTIAYTNQAVNQTTSTLPAPVGYPEHPAAHVNPGTKTVLVKNETFNTSNNVQEYPVPTILNHPLPPNTAKTIYYKKDTKHSTTNYYPDQPAEPGPYPNNFRAIEAPPPTVPNGGGPVKYTVEEPGYPPGNNTTYIYREERTNTNTNNRYGSPVPVPVPVPADQLYPHPHGPGGVPPPTTVTYKYSSTTTNATRNLYPPPAEREPLLQPFPTDGIDRTDLDGNPPKRLDDLMATFGEDGQVTYQSRVVNTSQTDSAGPKRAGPPANGTGPKPVDETMDDKSAPNQVASKNIAGPPVYYPPGHEMFAKKEMEASGWRAQVGVKSHCCTIWGRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLZ7</accession>
    <name>A0A084WLZ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP011134-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00019284</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024329">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLZ7"/>
    <dbReference type="STRING" id="74873.A0A084WLZ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019284-RA">
        <property type="protein sequence ID" value="ASIC019284-PA"/>
        <property type="gene ID" value="ASIC019284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019284"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003746"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010918"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012792"/>
    <dbReference type="OMA" id="TNQHNIG"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09367">
        <property type="entry name" value="LIM1_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09375">
        <property type="entry name" value="LIM2_Lhx1_Lhx5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000120">
        <property type="entry name" value="Insulin gene enhancer protein ISL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000075">
        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000046">
        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049618">
        <property type="entry name" value="Lhx1/5_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049619">
        <property type="entry name" value="Lhx1/5_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF105">
        <property type="entry name" value="DLIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB51241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="494" mass="52089" checksum="0EF72820A2B3BA8F" modified="2014-10-29" version="1">MAFGSVLQHNQHNIGRGEPPSGLGDPCAGCNKPILDKFLLNVLERGWHAACVRCCECHQPLADKCFSRESKLYCRNDFFRRYGTKCSGCGQGIAPSDLVRKPRDKVFHLNCFTCCICRKQISTGEQLYVLDDNKFICKDDYILGKGPHPMTDSLMGSASEDEDEEDQMRPGVLAGLVGGGTGAAGLHHGDGPLGASDLSVQSMSTDSKTGHDDSDQGSLDGDPDCRGDSQAENKSPDDGGGSKRRGPRTTIKAKQLEVLKNAFSQTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSKERRLKQLTSMGRGPFFGGARKMRGFPMNLSPGGLDEPGFPYFATDGKFDFGYGGPPFHPHDAPFFGGHPGAGPMPFGGPGGPMDHPGPIPMVGDFGMGGPDGGPGMMGPGGPGGGPGGGGGPGGFMGQQPPGGPGSNQQQQQQQQQQQQGPHGGPDGVGGMLGGGPRPGGGGSPVEFLTSGNFSESQNMQNEGLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM17</accession>
    <name>A0A084WM17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NADH dehydrogenase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019307</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019307-RA">
        <property type="protein sequence ID" value="ASIC019307-PA"/>
        <property type="gene ID" value="ASIC019307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019307"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="19083" checksum="89581DC9D3A8AC82" modified="2014-10-29" version="1">MHRSNFRLSLTTAITMTSRDDGDYNGRENPSGGPSMPTGTERQQSITRTRLVTRRKVDRVSAIITHRISLEGGEGEATGWPMYRRHVSGTFHVVRCPLVLCAEKLCPGKPLSHRQKGHTGCLAEVRPSSHTSDHLCIASVYVLGRMVDILSPFPRGIWRKEEGSTMEELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMV6</accession>
    <name>A0A084WMV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024520">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMV6"/>
    <dbReference type="STRING" id="74873.A0A084WMV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019616-RA">
        <property type="protein sequence ID" value="ASIC019616-PA"/>
        <property type="gene ID" value="ASIC019616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019616"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017057"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9176" checksum="351C15F89CA36DEA" modified="2014-10-29" version="1">MACATLKRSLDWESLNQRPTKRRRCHPFGSPSQQSASMAASASVMSPSSSSATSATSAAAAAAAASMRVMEPKPSPFAEATCSKLTPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN13</accession>
    <name>A0A084WN13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007373-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN13"/>
    <dbReference type="STRING" id="74873.A0A084WN13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019680-RA">
        <property type="protein sequence ID" value="ASIC019680-PA"/>
        <property type="gene ID" value="ASIC019680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019680"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020329"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF478">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9651" checksum="48DFD4B602A1DB24" modified="2014-10-29" version="1">MFITVGVISFVIAFFGCCGSWFQSRCFLVIYFTLVVLLFLSEFLLGSLAFVFRGGIGRMLAQELKYGIEKHYNVSDRGGFLTPSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNE9</accession>
    <name>A0A084WNE9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase 36</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Deubiquitinating enzyme 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein scrawny</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-specific-processing protease 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00019836</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01024593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNE9"/>
    <dbReference type="STRING" id="74873.A0A084WNE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019836-RA">
        <property type="protein sequence ID" value="ASIC019836-PA"/>
        <property type="gene ID" value="ASIC019836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019836"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012250"/>
    <dbReference type="OMA" id="VCAMAKT"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000085">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="107"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="535"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="911"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="538"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="781"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="922"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="973"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1087" mass="115339" checksum="6AA46B19A319F3E9" modified="2014-10-29" version="1">MHFVRLVRLQFRYFCQVVLRLLIPLWSSLRTTARRRPIRRWQRASSSACLSQIIEDGVTSSSTAASPAASASKKDTATLPTAKRTLFPRENVQIGWKTTGRKWNVGAGMINMGNTCYLNSTLQALFHVPAIANWLLSDVQHRERCDDGGSGGSCIICAMAKTLIESQSNQGAIRPHLVYSKLRLVCKHLVPGRQEDAHEFLRYLVEAMEKSYLGRFKNSKELDQYSKETTPLNQILGGYLRSEVKCPTCCHISTTFQHFEDLLLDIRKANSIDEALEVYFARERLEENGYKCEACKRRVAATKQFSLERAPFALCIQLKRFSVMGGKINKHVELRSRLDLTPYSSPALRGGSNGKLLYRLTSMVTHLGSTQHCGHYTAIGHTDAGGYHVFDDSSVRSIGMHNLTTTNAYILFYELESPVGSAGLPNGVCRTKPSATVGQPSSTATLTSMGHLNSDGGGSSGTPGKGTTTSSSPLRVLGTGGSGGIFPSKLEQKSTFIGPVLPAAASSASSQPNTAITATSNGSVTAAGQQGTSFSLVSSSQKSEPSGSKHTVDASFSSPSSTASTLSNASPLASPVKGMQPQSSQAGSGQPNSKTPKPSSSNGSASYTPTKSNGALKDEKKMSTAAPLLPSMPKLVSSSNKINSPLVNAPTQSSVVSLVPYETDDSSSSDDDDDDGSDKRTAVLIANGGPKRPKQTPAAAGGVYQNGLKPAKVLKAAVFERSEDNDENDDEHRRTDAADERQEMAASRSPQLIKTKSGLWKVSPSSTADQLSFPDSGSSGGSAPSSKASSPATSAGSSPASSPGGGQQPKQQQQQQSHQRNGIDASKSTVLTNGHRNNGSNHHQPTFNGSVGDKRKPMAVNGYHQENQSNGGGVGGGGGGKTRTTNGEMTTGSGGSTVQMLLKLSHRGYGAPVKSWDGQETAMDRELASERREERKRQIEDDRETEMDRGRVKKSKGTATPNGSFGSGGGGSSNPFQSYQNGGKWNGNRNGGNNSHYNNHQNNYHRGGGSYYANGNGQRYHHGGSNSNGFRNNGRRFGGRNGGGAGGGGNFHSKSYHHHQRSESSGGGGGGMASGSGNNGSNGFHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP38</accession>
    <name>A0A084WP38_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020162</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525363">
        <property type="protein sequence ID" value="KFB51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP38"/>
    <dbReference type="STRING" id="74873.A0A084WP38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020162-RA">
        <property type="protein sequence ID" value="ASIC020162-PA"/>
        <property type="gene ID" value="ASIC020162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020162"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010589"/>
    <dbReference type="OMA" id="HCTNDAF"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000217">
        <property type="entry name" value="Gram-negative bacteria-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785274" evidence="2">
        <location>
            <begin position="24"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="388" mass="43223" checksum="B542C3EF26441A88" modified="2014-10-29" version="1">MKRLSSLIVASLLVVTYFSGTKADLTTTESTCVPSVTTASGSLIDRGRTFCSGELIFEDNFDFFDFEKWEHENTLAGGGNWEFQWYTNNRSNSFVEDGALNIRPTLTADQFGLGFMTSGTLSLQGSYPTDHCTNDAFYGCVRVGNQQHIVNPVKSARIRTISSFNFKYGRAEVRAKLPTGDWLWPAIWLLPKRNVYGSWPASGEMDLMESRGNEALMLDGVQIGTRQVGQTLHFGPGPAYNGYPTSTLTKNAAPGQEFNRDYNTFGFVWTPDNITVSINGENLATIEGDFWKRGDFARHNLENPWRHGTPMAPFDQEFHFIINLAVGGVAFFPDAATNPGGKPWKNNSPQAATDFWNGREQWLPTWNLDKDGGKSASLLVDYVKVWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ66</accession>
    <name>A0A084WQ66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004363-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00020602</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525379">
        <property type="protein sequence ID" value="KFB52360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ66"/>
    <dbReference type="STRING" id="74873.A0A084WQ66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020602-RA">
        <property type="protein sequence ID" value="ASIC020602-PA"/>
        <property type="gene ID" value="ASIC020602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020602"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010291"/>
    <dbReference type="OMA" id="IESKHDY"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="652" mass="71038" checksum="C785A2C451DFE18E" modified="2014-10-29" version="1">MSSIEDVINHYQTSINKSLNDTARIVHCIGKLYKLPISVRHLQETGIGRTVNSLRKYDGEVGVAAKALVTKWKAMVAAEESDDDNHHQNHHNHHHSKSSEVKASSGHRNEHHSRSSGNKEQQSSGSSNHHNHHSSTSKQSNSRHHHRSKDGEKSTGSSKRHAEDGEDGGELRTPSSSSSKRSRKEHRTEPGSSTSVESPSSSHSRKSSKITSSTSSSSSKHRDRHEKPDERHSEKAGDSSKSKRKEKVSATSTGQEEDGNDESEPEDVADGLDGSGGASFADALAMIGFPGSSKKKSSGSSKEKEKVTITKRSPSSTSSSSGGHSSRAKLGGGPSSSRREGVSTIPSASELLSQKIKLEPLPEASEIVEALPMISPHYRPMPLNQTVMDCVFMGGRGGGGAGGGGQRRPLTEEEALGQSMQSKNLRTKVYSGMKTNAKGVIPTLYELCIRLLQDHLDEIGATGGIPFYILKPVLERANPTQLLHLEHFNPHFVEDSDVLWEQHCKRTFRAKQRNEEELETWREMFLRCSEERDAKLKSLTQNIKLAQEQAAAPIRKTQLAYVDSAVKPPRSVINKQARYGTARAPVVSPAARVAALAQGGNVAQVGDTRLRVAPGARDNAQAQVFQPTKPRKAPMMAKVLSSMKGFKTSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQE1</accession>
    <name>A0A084WQE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020683</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525394">
        <property type="protein sequence ID" value="KFB52435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020683-RA">
        <property type="protein sequence ID" value="ASIC020683-PA"/>
        <property type="gene ID" value="ASIC020683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020683"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020683-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7389" checksum="C362ABA82F1C1D22" modified="2014-10-29" version="1">MGKNAAKEGFVGGEVSGERRWDVKNGQRRWTMENGSASDQTCTALDVGRCRPAWWTYVCVFVCVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQI1</accession>
    <name>A0A084WQI1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQI1"/>
    <dbReference type="STRING" id="74873.A0A084WQI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020717-RA">
        <property type="protein sequence ID" value="ASIC020717-PA"/>
        <property type="gene ID" value="ASIC020717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020717"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008516"/>
    <dbReference type="OMA" id="HAPAYVS"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="20810" checksum="7637E88157DD7E98" modified="2014-10-29" version="1">MFVTFLSPPKCTVRQQVFVVLAAVAVGVNSVAIGVAAPATLVKTEEYDAHPQYSFSYDVQDSLTGDNKQQHETRDGDVVQGQYSLVEPDGTRRTVDYTADPVNGFNAVVSKTAEHAVVKTVAAAPVAHAVVAHHAPAVAVAHAPLAYHAPAATVAYHHAPAVAVAHAPLAYHAPATYVSHAPAVLSHAPVLSHTLYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQJ7</accession>
    <name>A0A084WQJ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQJ7"/>
    <dbReference type="STRING" id="74873.A0A084WQJ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020735-RA">
        <property type="protein sequence ID" value="ASIC020735-PA"/>
        <property type="gene ID" value="ASIC020735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020735"/>
    <dbReference type="OMA" id="FKYSSIC"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="252" mass="27332" checksum="F76ACC12793319C1" modified="2014-10-29" version="1">MKWTPKSIRSSIDIVCRNSFPFFLLKACTFAWLYGTLMQSSWSTMYFVEVHSNVAQSTTTTVWLQLKQSCQQGSLTIVRRTNSRKNTNIQQQLQYQEALDESDYQQPPFGSDSGAEGSGGGGAGGGGQGAAGDSGGPEAEFGQQHPPLSESELAFVNSQLSRELESMQPTSGAAIVAANRTDSTTGDELDTVDLATDNLPAVDTPDACDKAAVRLRCLLRQLQRGEISAELLQKNLHYAARVLEAVFIDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR22</accession>
    <name>A0A084WR22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003714-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025893">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WR22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020921-RA">
        <property type="protein sequence ID" value="ASIC020921-PA"/>
        <property type="gene ID" value="ASIC020921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020921"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005102"/>
    <dbReference type="OMA" id="HEDVCFR"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF109">
        <property type="entry name" value="CHORION PEROXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="875"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB52666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1274" mass="142049" checksum="F7EDED979C9F5FB6" modified="2014-10-29" version="1">MGYGTTPGRRLLREPPIPPNIMHAPANTAGPLYVNFPWGCEKENANTSAPNTGYENVSLQAKSKRFDGCQTVTNCSRLXXXXXXXTPSPPLSPPYLAAKINACRERAVDEKEKKNLHMGGGETEARSCAFCGVGRLNGLHRTNVEYVAIGRQAPPKISLKRTPLEKLCPSRETPRCVPASLRYRTHDGTCNNGQRPRWGSSQMPFHRFLAPEYQDGVEGIRRSLTGANLPSARFVSLVVHGSRNEEAPVTMMLALWGQLIDHDVTATAQPRSLNGSTPRCCSGGEESTHPSCLPIKVPQDDPWLSHLGVRCLEFLRSAPAQRRDCLLSWREQTNQATSFLDASPIYSSNPRTSDNARIFRSGLLLFGRGPPHEDVCFRAALANQCIRPGXXXXXXXLFQHITYREFLPLVLGREVCRLFGLELETSGYYRGYDPAVNPTIANEFSAAAFRFGHSLIQNTYMRADRNHRFIANNVSLHEDTAEGDFGGPGSLHRLLRGMVNQRALKRDEFITAELTNHLFQTKSFPFGLDLAAINIQRGRDHGLPAYVNWRGPCGLSTVKDWLDLDRIMGPASMNRLRKAYRTVDDIDLFVGGLAERPVLGGIVGPTFSCIIAQQFSNLRKGDRFWYENGGFESSFTPAQLESIRQVAFSQVLCRALGGGGTLQPFVFLPPDFGQNERLPCESRLMAPIDLNPWHLVTNGNTGLQSRPQLTIGPTVIISDKLDLKPTTSTATTTGAQVSTAIDHKLDLRPTTKPTSKRKPTRKPTTKRRPTNQASLVSNNLDFSGTRATTNGTRRPDGQGVNKKKKGSRTRRTVEEQEGRGNGYYQAPEPPTDYNDYDDDYYDAPPPYLAYGYHRPTTTTTTTTSYYPYGGGGYYYNTEPPPPPPNPYFDTRRPQPLRTTTPRRRLSDKLTQVDRDPQRPRATTARTPTQKPPPAHHPSHTSVFSVDFKSLPHDAGRSLVALGDPSNIRPLNDSANALFTGTNGSSTISSFASASVSTPSSTYRVVSSTPSSTSSVGGSSPSVTRTFLPTGDLPMKLSESFSTYDYDNADYDETRPDRLTNRPNSHAIEGTDLVQLEDHDGYLRPEQTHFEPLVRDRDLTGTHTYRDYWTPDRTKTRTYADQLDTNVRPLYADLEPDTDLYRRYAPGHDEQLLLDEYSDQFVGQLLDATGRDRQVTKRKRNRPEPRSIRDDTDRERTTLTKLKDKRPNNRPKVPKKPAAISLVPFVLLTSIDRPDNWVMYNSKPSKRRKPPPAVPLLKSDTFSLSEFPSPIADPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR62</accession>
    <name>A0A084WR62_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002942-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020966</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025933">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025936">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR62"/>
    <dbReference type="STRING" id="74873.A0A084WR62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020966-RA">
        <property type="protein sequence ID" value="ASIC020966-PA"/>
        <property type="gene ID" value="ASIC020966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020966"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010489"/>
    <dbReference type="OMA" id="MGASLCH"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB52706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1060" mass="111253" checksum="F4427F63D4723A65" modified="2014-10-29" version="1">MHATNEESRHRNERRSTRARSRNSEDRHLFICFVNCQIRSGVENKDEILSFAQLEARQQLLPEEAEQCVSGVEPHNTAPVAAEENCAVPSSGAEIVTTEQTIATIPVRSGINQTPTVKLGANNNNNNNNNSAEELVELFSGGVASAGKVCVKVAAESEPASNRILRELNVNNSSSTKPGSVAAALPSVGRPVSVTASIFTSLPNGGSGGGGSGVQSAEKPKPAVKQLGTAVQPQQPSPALLQSVTAKLFVTLPASGGASGAGGCNGVSGGGSGAAGSKPQHATEKIFAPRTEDMNKGFLMFSEEEPGLTMLKDEPDDLTHLAPTAGDACIPLEESGTFFNDEMFGDFIIPDSYTLLQDELCSLDSQDTRLDGTSMVVQSTPSQNNQTSPGSLSSSASSCSSSSPVPSSPSRSLSSHPSSPSGTSGLGSSASSAVSVSLDHNSATGRSIGSQHNATSNDPFINYRDETSEVSPSPHLLSPGISKSPESSSLPSLCSPNGSLAEDDLAFMSLNMDEIDLTMRAPYISMSEVDDLPLLTSDDLLWGAPAATIDGSAHGGPFGLSGKFFIKDEFGALEQTRQQQQQQQHQHQMLIGKQSHSLITDITIGATDSSARTNEGNNDSKSTQQSPPQPPPSQPSIESSLAALLCGGNVISIQAQETQPNASGNNASNQILIAQQHHQQNEPETQCQQNGKRMKLLEESLLQHPMVVLPASLKLCDGWKFDDLLQLNGAATVKLGQQQAQQQTKKPNSPTNGTSHKRSLSGIDGVEPTETGLSCKRHKAAGSTSSSSSAPQLLQQLMAPSPVPQKLKGRGRSGQDGIGGRWPNGQLGGAGGMQQEQSGNSVLMNLLVSGCDDAIPLVPPETLIDDTGSNTEAKPPNDTTEDVLMNLGDEDDSDMLFSSANPLIGGQALLDESIARPLTIRTDHDVLPTTLSGASGRFLGSEKPSAFPGPSTQQDAEFSMTVSPSLLTPTDLEIWRAIQAGQLDPKKLTPIVGVSRSDRGLLDELDPVEVNLLAALADPGGLQLSDQQQQQHRDGAGLPYEGTFRTIAGPEEETLQRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR90</accession>
    <name>A0A084WR90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Asparagine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020996</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525404">
        <property type="protein sequence ID" value="KFB52734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020996-RA">
        <property type="protein sequence ID" value="ASIC020996-PA"/>
        <property type="gene ID" value="ASIC020996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020996"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="297" mass="33773" checksum="714320FEFF86BBAC" modified="2014-10-29" version="1">MRTIHFGRWNDPTGRIKLCRLRRVSVLQDFLRLNRGTQANCQTGEPVLRYQTEPFDDRCQTDRRYTVFRFELNLTTKLQYGFFVRRYPTVTMHRLDSSKHLVTLITDRYPTLQMETVSFLMKYTYLCLPNPLRSGFLLINARSGAAEERLGWFFVERDSILAFSPLLSPGAGGALRSTTKPGSGGLVTVEGAVELPRLDTFETSERPEMEDVPGTATVIGRLNGLWLDTDTICLSNSDSTDLSDGARLMFTKGTAAFNCAEVIEEFLAIFTWFNRFLLIFAVRFPTPFNGAACKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRB0</accession>
    <name>A0A084WRB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021034</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026008">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021034-RA">
        <property type="protein sequence ID" value="ASIC021034-PA"/>
        <property type="gene ID" value="ASIC021034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021034"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="17923" checksum="ADA0EAD829EE9AFB" modified="2014-10-29" version="1">MLAFLLRPSALIEGKGWRKAKPAAALSKAKLKQAKTHCYSEGAREARGSCRAGCRGVWEVFGALSNGGGHTATPPRHRIQHAKRGAGNEGQGGGGKKPAHTAPKRRENAVCQLCAARVTDGVETHSSRTRNEATTTRFDRTPDGALSRAATAWDGRGREWAAAKEAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRD7</accession>
    <name>A0A084WRD7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP002462-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00021047</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026021">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRD7"/>
    <dbReference type="STRING" id="74873.A0A084WRD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021047-RA">
        <property type="protein sequence ID" value="ASIC021047-PA"/>
        <property type="gene ID" value="ASIC021047"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021047"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020216"/>
    <dbReference type="OMA" id="NAFTMVY"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001735">
        <property type="entry name" value="Opsin_RH1/RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00576">
        <property type="entry name" value="OPSINRH1RH2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 17" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="5 17" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="66"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB52781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021047-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="373" mass="41773" checksum="4979C8BBC40B28F0" modified="2014-10-29" version="1">MPYYGPMQQAGLWGQPISNLTVVDKVPPEILHLVDPHWYQFPPMNPLWHSIIGFVIFVLGVISIIGNGMVIYIFSTAKSLRTPSNLFVVNLAMSDFLMMGTNAFTMVYNCWFETWSLGVLMCDLYAFTGSLFGCCSIWTMTMIALDRYNVIVKGLSGKPLTNTGAILRILVCWLIGVFWGILPMLGWNRYVPEGNMTACGTDYLTEDWFHKSYILAYSFFVYYIPLFTIIYAYVYIIKAVSAHEKNMREQAKRMNVSSLRSGDDGKSAEMKLAKIALVTISLWFMAWTPYTIINYTGVFKTASISPLATIWGSVFAKANAVYNPIVYGISHPKYRAALYRRFPALACNDVPAGDEKSLASEASGITSDANPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRK7</accession>
    <name>A0A084WRK7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00021124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026140">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525406">
        <property type="protein sequence ID" value="KFB52851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRK7"/>
    <dbReference type="STRING" id="74873.A0A084WRK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021124-RA">
        <property type="protein sequence ID" value="ASIC021124-PA"/>
        <property type="gene ID" value="ASIC021124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021124"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004998"/>
    <dbReference type="OMA" id="ISIQMAT"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="14648" checksum="19336D0031C7F743" modified="2014-10-29" version="1">MTTYFNYPSKELQEELARIAKQIVAPGKGILAADESTATCGKRFADIGVENNEDNRRQYRQLLFTADQRLQEHVSGVILFHETLYQKGDDGTPLVKLLANKGILAGIKVDKGVVDLMGSEGECTTQGKFVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT43</accession>
    <name>A0A084WT43_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00021701</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT43"/>
    <dbReference type="STRING" id="74873.A0A084WT43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021701-RA">
        <property type="protein sequence ID" value="ASIC021701-PA"/>
        <property type="gene ID" value="ASIC021701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021701"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008309"/>
    <dbReference type="OMA" id="GPWVNSE"/>
    <dbReference type="OrthoDB" id="10055808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785322" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB53387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="18406" checksum="5802165837B24262" modified="2014-10-29" version="1">MFKFVLATIALTCTVLGFAAATSCTNPQVQTNFYSTSDATIVSQIGFVTEFTLKCSNAGAEKLPLFAEVVGKLAPVVRLGENKYQVSWNEEIKKAGSGTYSIRLFDEESFAAVRKAQRAGEDVQSVKPLTTVSVHFSGAYKGPWINSEILATGLVGFVAYVAFTTRSKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU49</accession>
    <name>A0A084WU49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022123-RA">
        <property type="protein sequence ID" value="ASIC022123-PA"/>
        <property type="gene ID" value="ASIC022123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022123"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="288" mass="31990" checksum="E648FFCA11F28B39" modified="2014-10-29" version="1">MPNVETHTHTETEWSGLLNRRTPLLVTLPVRQTSKHTTKQSGPPSILRCLSFQPTLVVPQPETRIVGRPQEGRAKEQQYHLLMHPNNIGTGIKIFTFGVRLRSVWPKCVRLRMRTEPSLPPFPPAKPPLMERRANGNGGSRREDLHRSPTERLGPEVEAEACKLMSTSAGTVFGRFVSDAPDPRSFPMVPAIPSHSLPNGETRPDVWGKERSCGCVCVGVCVSTCFDEEVPDDDADVMMAVMIVTAMKLMLIGYGSAIFRPPSPKVLPTPKGDRTKRHLGDRSWPFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAT2</accession>
    <name>A0A084VAT2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000967</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524214">
        <property type="protein sequence ID" value="KFB35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000967-RA">
        <property type="protein sequence ID" value="ASIC000967-PA"/>
        <property type="gene ID" value="ASIC000967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000967"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000967-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8204" checksum="09B91EAA6FDE59C2" modified="2014-10-29" version="1">MKIVETATVAPVSIVTPPSVPSSTASLWKPDVLAEPAFLPDTITLTPSPWRLKNARNPPFTPTPTSEGEKRSFSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB75</accession>
    <name>A0A084VB75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002705-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006052">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524335">
        <property type="protein sequence ID" value="KFB35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001365-RA">
        <property type="protein sequence ID" value="ASIC001365-PA"/>
        <property type="gene ID" value="ASIC001365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001365"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022891"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12004" checksum="A7053999D700641B" modified="2014-10-29" version="1">MITSISSNKILPHDNFPTKLCYPCAELLRNAYGFLQTCSSSYITLLKCVQQPNEENDCKVQVESVQVSEDTSQESTDPDDGRTEENGEDLMDARIPDSGIQMPDNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBP4</accession>
    <name>A0A084VBP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC001969-PA"/>
        <property type="gene ID" value="ASIC001969"/>
    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001969-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6964" checksum="E2B47E1CEDD15110" modified="2014-10-29" version="1">MEERSSDIVVHNHRRGHYEIVRRNANRKPAIATNVQPKKGNQPTKSQGKNKIKPRRVEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBS5</accession>
    <name>A0A084VBS5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00002086</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC002086-PA"/>
        <property type="gene ID" value="ASIC002086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002086"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7958" checksum="6605B6726CD49DC6" modified="2014-10-29" version="1">MLKPIFDARKVVFRVPCVSSEVPGELDRKVPAQFHSLTPDGVSVTRENSHPTRWGKPSEEITGEDYETFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC35</accession>
    <name>A0A084VC35_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP012949-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524565">
        <property type="protein sequence ID" value="KFB35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002333-RA">
        <property type="protein sequence ID" value="ASIC002333-PA"/>
        <property type="gene ID" value="ASIC002333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002333"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011071"/>
    <dbReference type="OMA" id="MVTCQKW"/>
    <dbReference type="OrthoDB" id="7741378at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783304" evidence="2">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="30766" checksum="6A64E5568D1C6092" modified="2014-10-29" version="1">MVTCQKWLTLLLSVQLLVVGILAIPSVPNKVDPGQNNDDASVTPLDSDTGDDRELKSDDDGYDFLSIDQLFLNNPQYRQLISDLQAHTFGSNWRRKRDVSENELPEALRSEEAQSSPRTSTVASSTTTSTMTSSTTTTTVGSSTSTESLTSEVATNRDITSAAPSSDLPRAEALTSTSTKSEATKPSTTSAATSSTTVSTSTPIRGSTISTSASHGSSGSTEVPTARNATLEMTTAAAPIRASTPRRLSHKNGSNKNKNKLSSAAAAAQAQAANKPTTNAGLLISLRRYYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A084VCR3_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Bromodomain adjacent to zinc finger domain protein 1A isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002660</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002660-RA">
        <property type="protein sequence ID" value="ASIC002660-PA"/>
        <property type="gene ID" value="ASIC002660"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002660"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002660-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10800" checksum="118C8A38215A42F6" modified="2014-10-29" version="1">MGATVQLQPPNGTEKLVLINKDVIMLEKELSGKNVYGWQRVERGEYGIGTGSAHHTLSKNRGKITYGPARDTGSAEGSFQRKPFVSLLSSHQTRRIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD05</accession>
    <name>A0A084VD05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002791</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524641">
        <property type="protein sequence ID" value="KFB35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002791-RA">
        <property type="protein sequence ID" value="ASIC002791-PA"/>
        <property type="gene ID" value="ASIC002791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002791"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="5620" checksum="CC3B4154B1050D26" modified="2014-10-29" version="1">MIGTPFVESYEKDNGGNSILCINYQQAKVSGFTLTLTPSPQLHCRCVYSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD76</accession>
    <name>A0A084VD76_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002874</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011187">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002874-RA">
        <property type="protein sequence ID" value="ASIC002874-PA"/>
        <property type="gene ID" value="ASIC002874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002874"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023674"/>
    <dbReference type="OMA" id="SHANWRG"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF103">
        <property type="entry name" value="RE10370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24593" checksum="CB7FFDE72A09EECC" modified="2014-10-29" version="1">MNDYKSQIGDASLMQLFIPGTYHSAAYFTKLSAANFEVVNKYSITQGWEDVRSQLRLGARFLDISISQNLTPEEQFWTFYNVVQMHPLRIVLEQVRKFVEETNEIVIFDIHSFPTGFNSTDDHHGLIQFIRSEIEDFMVSPSVGWDGTLNQIWATGKRIIVCYANAEVVNLYPYHLWPTTHHRLADVDDKTRLKNYFYNKQFTYRLFSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE45</accession>
    <name>A0A084VE45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acyl-coenzyme A thioesterase 5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524774">
        <property type="protein sequence ID" value="KFB36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003360-RA">
        <property type="protein sequence ID" value="ASIC003360-PA"/>
        <property type="gene ID" value="ASIC003360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003360"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9146" checksum="3088F31CC7B88DF0" modified="2014-10-29" version="1">MASAKVSENPASQQIRSRCPGKTPDSGRWVPQQTPELRQKASASGKRRDPIRNGKIQMSMAHQSGPLQPVPAVPDVAPVSGCINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE86</accession>
    <name>A0A084VE86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A2M_N_2 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">AGAP010831-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003400</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003400-RA">
        <property type="protein sequence ID" value="ASIC003400-PA"/>
        <property type="gene ID" value="ASIC003400"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003400"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016169"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003400-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9971" checksum="D65F3CDFDB0B6D58" modified="2014-10-29" version="1">MDTPIDFTITCTEKTSFIVYYIVSKGYIVDAGYRTLNKVNNFQLQVKTTINMLPKSTIIVATWDKQKWAFDYMDITFGQLRNNVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VED6</accession>
    <name>A0A084VED6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003454</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524777">
        <property type="protein sequence ID" value="KFB36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VED6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003454-RA">
        <property type="protein sequence ID" value="ASIC003454-PA"/>
        <property type="gene ID" value="ASIC003454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003454"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7683" checksum="E935EF31FE3C73E2" modified="2014-10-29" version="1">MEVPTEPHRELVPSKCKFESHIPPHENRSLLAKDSSGEQIFFTVCRSTYGAATVIMCKLRSDNDCSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEZ5</accession>
    <name>A0A084VEZ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007568-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00003795</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VEZ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003795-RA">
        <property type="protein sequence ID" value="ASIC003795-PA"/>
        <property type="gene ID" value="ASIC003795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003795"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013641"/>
    <dbReference type="OMA" id="WAIKCGT"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="615"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="960"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1311"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1360"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1388"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1462"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1486" mass="165621" checksum="C543911BB9D8827B" modified="2014-10-29" version="1">MAPRKRKVVVAAPVPSPEKVKFSTAVMQTMLNAQAKETTHPKLINQLKRLYTSVPHDSFMKSFIQVIKRQMQHEESNEYANNVLKFCAKFVAEPEYSEQSVTHPVMESIFNWLLSTISGAPLVRFRICQLVNLILNALGSDATLDDTICDKILRYMLERMRDVSQQVRVQAVLALQRLQDPSSPEDTVVRAYTYHLDKDPSAKVRQTIITCLGRNYRSIPNILERLWDVDDRVRRHTYMQMSSFPVRQYKVAQRLKFLEQGLNDHSESVRKVVRNVMIPQWIESYQRDCVAFVEALKLDADEQEMDRFRKTSKMALSEIFSKNGVKEMTEILQFSDENRTVALDQLTIERAICWQAMLEHIQKTRPDELEDYMPELSKFCEYLKLLVENPGQAAFMKCTNSNTPNISNQTSPGQSDGMDKLQQLYYQYILLTLLEIVTMYDFGDVFGCDSLKLVLSAILCNETLNEMNVKSIMQTFEKLLPNVETRLKFFVDLVNSILEPSRQDVSNSSRVLVESYLERHPEQTALKLKISSLRLKILDLKEQETLLVQKKDYGGAQCVSEKLNQCNEEFANLVKPLLQEMTMSISNTTGDSSSALVFRDSMLKPRRMTQATIVKCLQVCFYLVNSPTVRGLDPTVCDLYKSFISRYVQSSQLHTRNWALRASTAFSMLYDGLSKDTFQLLYQQFLDTASTRLWKTAIEGVFELLDRYGFEHFDLDKDDTAKDDTSRTNKSSRQLFNRHSTGHPDDLSSSSTSCNGNEFYKMSIHFMDTCDDNVICSTIVEGFCRLILHGHCTSPDIVSKLLLRFFNPTTDPETQQVLGIFFEAMIRKKRQELLQKALLRTLFAVLEAPNESPLAEVHPETVVKFVINSTQPVFCSPGVNPHNAIAVTFLRVVHDNLTLKDLLRILSNQLLVLDITEDPVLRGDLASAVNGILQESNLDPKIVKKLSTFREMMLGKIREPLSFSSSRAPTMTTTTSATELGDDGIEEPTPNEKEAAEADQDEEDDDELREEGEEEDEDVEVDRSSDRPQINKSILQEDSDVDLLASPMRAAAGPNTPSTPAPMTTPPQLERSDSTMKSLRRSLCFGSCPPPKGQPRETGTTLTAPSSEGTFKVPDASALRKIRGRTKEPSASSAMKERVMQQAPKESEQAEEFEIPATQEDGEDDHSSGNSHVSDSDSEIPETQPSPVAVGSRKSITGRTSARRNAAASKRSDSTSSTTSDSTSEGEAVDGSPNVTVIRINRSARPMNKVAAKTLYERSIATPGTMPRVTRHVSRQQTINGKVMTRKSLSAIGAASPKLVAVVNEGERNSRAGQSNAKTPTRSSQRSTKVAEKSVSTPDRPTRSGSTARRSKNGADDRSPSPSASTSKTRTSSTPSSSLPKTPTRTSARANVTTQPAAVSSPGKRSRDRKTPATGANSSSSSNSGTSTSSPIRLKRAAVVLTPLSVASHRHSKHREVTAGAISGTSTPIRTSSPRSRPSRKAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG06</accession>
    <name>A0A084VG06_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002067-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004069</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG06"/>
    <dbReference type="STRING" id="74873.A0A084VG06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004069-RA">
        <property type="protein sequence ID" value="ASIC004069-PA"/>
        <property type="gene ID" value="ASIC004069"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004069"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001702"/>
    <dbReference type="OMA" id="WSTVNRV"/>
    <dbReference type="OrthoDB" id="6501018at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF69">
        <property type="entry name" value="GH07286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="504"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004069-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="573" mass="63327" checksum="786E226FE3C74095" modified="2014-10-29" version="1">MMSLRRISRSIGFCLSTRGYSISTGATAAKVLTVDANGDRKKVQPNLTRPAPGVTSVSSVPKSNKTRNNPIVAAAFASLRNDDPPGKDETVAVDHKQDIQIDEMILKANTVTELLAIADVTKVTRKQALKIVSILAEWSSIKKANLSEFESDPRFVDLCSLLGRTGQQRSTSSKPSGQAKQRDLHVDDLQTVLGITANDEAAKLIAGLTLPQMIKVMSSLAMKKKRSIPLLRSLSFNIASNPGQLNLKECGDMLYAMASLNYRDVVLTARICSDLEQELAKNTDKIAPIVSILTSLGMLRYRDGTVLDNLTGWIAAHHELCKPTQLGSLLLSLATLNYEPISMDAIKSKLVVNVTENDFIRSTDWLNTVWSLTILNSVTGDQLSSVLNPEFFHRLQEERRGSVQPSMKMKLLNLAAAAKRVPGAKEMLLATHQVDLFVPFEPTKEKRVLITGMLDALKSLIPSESMVKINQATTMGFTIDAECVLDKKCLPLPVDKEHEHGTRIALLVHDYHDMCQGPHAALNGMQILYMRLLEQRGYTVLSIPYSEFNTSDKLLKRVEYLQKKFKSIVTSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG44</accession>
    <name>A0A084VG44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">High-affinity iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004111</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012632">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004111-RA">
        <property type="protein sequence ID" value="ASIC004111-PA"/>
        <property type="gene ID" value="ASIC004111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004111"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009046"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10644" checksum="37CDA48B2BEB631A" modified="2014-10-29" version="1">MQLCSMAKAGCTRTLFRFQPKEHSLPAEVCLSVIALIYIFLLLLLLLVMPSVCDARIRFIMLPAGSFEAHGAGQGVVDFRSNSVGGGFPARSMKDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGF1</accession>
    <name>A0A084VGF1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004248</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524821">
        <property type="protein sequence ID" value="KFB37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004248-RA">
        <property type="protein sequence ID" value="ASIC004248-PA"/>
        <property type="gene ID" value="ASIC004248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004248"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004248-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7945" checksum="9AA08CD92DC499B6" modified="2014-10-29" version="1">MTSLFFTIMHSRYHSISVGLGSTTPTTTMMCKSRPNARLVPGNMHPDLEEDSFVRTKDHKSTAATFGYHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHA0</accession>
    <name>A0A084VHA0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Large ribosomal subunit protein uL10</fullName>
            <ecNumber evidence="6">2.1.1.319</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">ZHAS_00004637</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01013150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHA0"/>
    <dbReference type="STRING" id="74873.A0A084VHA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004637-RA">
        <property type="protein sequence ID" value="ASIC004637-PA"/>
        <property type="gene ID" value="ASIC004637"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004637"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018294"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018336"/>
    <dbReference type="OMA" id="MAPSQCK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 22" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="11 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="27">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="25">
        <location>
            <begin position="278"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="28">
        <location>
            <begin position="397"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="26">
        <location>
            <begin position="624"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KFB37344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004637-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="828" mass="92511" checksum="9D3384178D60FBB6" modified="2014-10-29" version="1">MSDEDDCPPLCEMDTADSNGEDDEWEVAEEQNEPVKCLFCDSISPTMTVAIRHAKQQHDFDLAGVRRRYHLDEYSYIKMINYIRREKPSAEQFKVAHTGSSLPWADDRYLKPVENETWLMFDLDELDEIMLNNGGSNGGNGSLGEKENGTDIGETMTLTTDQYRKLQGIINDLTAQLREKENLLQHAASSMEKMKQSFRNVMEEPTPSKEKVKGVGGDQKLQQIKKKLEHCVSSVSVDDDQGYFNTYSHFGIHHDMLSDEVRTSSYRDAILRNADIIKDKVVLDLGCGTAILSMFASKAGAKEVISVDQSDIIYQAMDIVRSNNIDNIRFVKGRLEDTELPVEKVDIIVSEWMGYFLLFEGMMDSVIYARKQYLRDGGLILPNRCNISIAGYGDLERHNEFIGFWKNVYGFDMSCMKKEVLREATVEECKPEHVITNANIIANFDLMEVDVDCPNFSYEFTLSVKRDSHLTALVGYFDTFFELPEHIEFSTSPYTRPTHWKQTIFYLEEPVPVSEGQSIVGKFICRRDPKDQLLDEYPKCFIVGADNVGSRQMQTIRMSLRGTAIVLMGKNTMMRKAIRGHLENNQNLEKLLNHIKGNVGFVFTKGDLAEVRDKLTESKVRAPARAGAIAPLHVVIPAQNTGLGPEKTSFFQALSIPTKISKGTIEIINDVPILKPGDKVGASEATLLNMLNISPFSYGLQIQQVYDSGSIFSPDILDIKPEDLRAKFQAGVANLAAVSLQIGYPTLASVPHSIANGFRNLLAIAAVTEVEFKEAETVKEFIKDPSKFAAVSAAAAPAAAAAAPAAKVEEKKEESESEDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI08</accession>
    <name>A0A084VI08_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00004844</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI08"/>
    <dbReference type="STRING" id="74873.A0A084VI08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004844-RA">
        <property type="protein sequence ID" value="ASIC004844-PA"/>
        <property type="gene ID" value="ASIC004844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004844"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012837"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="52"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="240" mass="27435" checksum="3AA92997B545F4A7" modified="2014-10-29" version="1">MVNKVINFHKQPPQSRALTNAITVPCVLCVNFHESSIDVLVMRCCWLADGVGIDINHKWDRKVRRTKPKSLDVYLRLLVKLYRFLYRRTHKKFNKIVMRRLFMSRTNLPPISLARVAKLVKLRSEKGKNPIAVVIGTVTNDDRKLNIPKLRVCALRVTEKARARILKNGGKIYSFDQLALLAPTGKNTVLMQGARTAREAFTHFGRAPGVPHSNTRPYVQSKGRKYEKARGRRSSCGFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VID4</accession>
    <name>A0A084VID4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005040</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VID4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005040-RA">
        <property type="protein sequence ID" value="ASIC005040-PA"/>
        <property type="gene ID" value="ASIC005040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005040"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008512"/>
    <dbReference type="OrthoDB" id="6758171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005040-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="330" mass="36387" checksum="4F2DDF12E35B7203" modified="2014-10-29" version="1">MSSERRWKDTFRVDFSAWASKPTREEVITLISKMIMAKECVVRTHLSQVNQTVYVQMSSLEQAQEVVERCRGKHGKKINGVFTPYDIEMEDAAHHGVPCRTNRQELAVTYATTLTRTSNVQERLHKEKPTRTQQAGVSEKPAPTKKAPEITISKSPSPARDPVAAETSAQNVSVPVHTPAQPPPADNSVLEPMADNATEDSAMQTVPGGLSVDDIVFDIPLDSSSVSPTTDETITLAGVKRPGDGLDNDAAKRAGLDAELVVKRGPGRPKKTPVVAPVGKVNVNFHLVETQEKRQLSPKGKPQKSRSDRLYRFFQPAKRNHIKRVTMARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIM0</accession>
    <name>A0A084VIM0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">(Mt)TrpRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00004981</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01013369">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIM0"/>
    <dbReference type="STRING" id="74873.A0A084VIM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004981-RA">
        <property type="protein sequence ID" value="ASIC004981-PA"/>
        <property type="gene ID" value="ASIC004981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004981"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005473"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB37814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="351" mass="39258" checksum="C3890402DE40FEBF" modified="2014-10-29" version="1">MLIRRTTSWPRKVFSGVQPTGALHIGNYLGAVKRWVELQEAGEDVTYCIVDLHSMTIPPDPDTLRHNTLQMTATLLACGIDPNRATLFLQSAVPQHAELSWILGCLTTMARLTHLPQYKEKSANMKEIPLGLYLYPVLQAADIMLYKATHVPVGEDQIQQLQLAQSLARAFNNKYGKTFPLCETLVNDGSRLKSLRDPSKKMSKSDPDSKSCIMLMDPPDLVLEKVKKSVTDFKSEVTFDPAERPGVSNLVTIHSLVSGKSTDEICQEAVGKNTGQYKLAVAEALIEHLRPIRELIEQYSRDGGYLSSVIEEGSERARATAERTIDEVKEKIGVDCFNVGRLRRHVRRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJB3</accession>
    <name>A0A084VJB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002132-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013500">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524866">
        <property type="protein sequence ID" value="KFB38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VJB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005346-RA">
        <property type="protein sequence ID" value="ASIC005346-PA"/>
        <property type="gene ID" value="ASIC005346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005346"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003331"/>
    <dbReference type="OMA" id="MELRCKK"/>
    <dbReference type="OrthoDB" id="10053467at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF-9 ANC1 homology" evidence="2">
        <location>
            <begin position="648"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005346-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="710" mass="73294" checksum="B04B03084A41921E" modified="2014-10-29" version="1">MYLIGSQLLSRHTKEQGXXXXXXXNNPTVPTSGSSSSSNSHPTGSSTGVLSGGAKNSDTGGQKRSSSEKEKKSSKKEKKSYEKEKDRTVDASSSGQRKVERSGDVKSNAPQSSSSSGQQQQMGFSKGGDVPPGGSTKSSSASSSGNKSHPPNDGGQQTQKDMGGKSSASTNSNASGSGGYLKEKKIHGSVESMRQDPTLNTSSGAAAGPPISSQKTGEKSDKLDRDKDEARKHKHKKKDKSKDKEKDRASTGKDKKERKEKDKAVAGGSGSKGSSFSTPTREANDALLPSKASKPHAGGNEPAVKPTGHDRDKGHHGFSTGGGGSVARHQQQTSTKSSTPMAALIGEISGEDNSNDSDERTGDGDSRAPSTIANEKDSEASNSSIADMMLGTNSSMAPGQQRPPSTTSSSTTASSVRDSTEKYHHHKSKKEKASSRAAASSAPTQPLSPVVSEAKDAPPASASSSRSSAPTSEPTKKRKRKNKDTEGPDKMPPRDSTGPELATRERRSLSPPSPPAGTASGSSLMEPPAKVPKKDDSYGGPPGPGKLPDTSDHTNNNNAINNNNIRHSGSGSGGSTAGGDDSSNGNNSYFGLNNIPPSIAGSGGGSSSLSAGGVSTLLNSSNSTATLSSGIGGTGTGSSSANSLTGDYMSELKDLQHKIMTLQDNSELQRVVEMIAATGCYEITSATFDFDLCALDRLTVQRLQEFFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKQ0</accession>
    <name>A0A084VKQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein LOC101240316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005821</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
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                <person name="Zhang D."/>
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                <person name="Shi L."/>
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        </source>
    </evidence>
    <sequence length="2121" mass="232487" checksum="12CFAD54D21F28FE" modified="2014-10-29" version="1">MCTPAPASPPSPSTTTTTTTTTTTTTTTQNRVLEQTNRDRTKRGDGSNNGGGGGGYASVAPQPPASAVASAGGQQVASGSGAFFQSTSNASTTISTTSSTTAATSTLGGGGGGSSGRGSQRPSEKAGESSRAKKYRHQQFSKNIYIGTKNAEKWDTLRNVLLFKNDVEFVSFLLKLAESNCWKKELLNGFHDDTMAQPKSSATGGKGVDEGGAGATPLAYRERGLGRRGSGDEYVGEAMAEEDGGDEEEEGEEEDVEEDDEEDEDEEDEEGETDGVKKAGVVVVPLVQRKLAKQEEDDDVEDEEEDDEEEEEEMEDEDRRPKCTELQPGAGVADTELSVGSHASYLMEDIVKKTLRKVPTPGPATSSQQQLPQMQPPQQSNEVQQDSISSTMGSVSEDSLNTETEVLDYRIAEKIKTELEEKQKLERRSLNSEELPTTSNFYEQGDLDGAGAPPDEKPPVPLGGTKKGQLGARGAAGDTGPYTVGVRKRGKRAHPAGDGGRSVDLHIEYEEQEYRPVGRGGSGEPPEKAGFGGPDGGKQLSLHHPSQHQAPTQRRGKGAGMAKNKVCTGCNVKHGLDLCPLNAPLLTIKNKIELNQWLEQNEELIKKHKLLATGATAATAGADSDTFPKSRTTAGHGLSIYTTTFISKYTKIGPLTGQVVRETEIQDDSTMRFIFETFDGSKSTYTSTENKNLSNWLRYIRPARTRDQKNCVLQVYDGSIFFTTSRDLEPGTELLYWSDDSNSAWGKKKMEKTNCGGCNLKFDHPIYYRTHCSVFHDPGFSLTIRKYHCKVCGVAVLGKENIMKHAEKLHDGKGAYQCQFCQKFFLRLNYLEMHRTYGCSANPQRTRPLCDFCGRKFCQPQKLKVHIKRMHSDMADVLRDFQCKLCSKLLGSRAALQRHSKEVHSRNSAVVSCPRCQKLFQNRSNLKIHMLTHSGVRPFKCAENECTAAFTTKQCLQFHYKKVHGYTQEQMPKIERSVAYTFDAYSGGLNDGMIDEVQRRQRHKSSASEDGAYGSEKVERKKRSRHHLNHFDEVSLHQAQFQAQLELPQHTTDQSQNVNQEPTEQPKKTPQHLQSPQLDYPNTPPSQQRLSMTHQSTAQHHQLGQVLHDPDGLSKDVELQQQKLLRQHLVAQQSDGHLETDTEPGIGEQHPNHQHDLHSNHEHSPLENAQAAMHKSEHDEQSLHHHHHHHLHHQNQPQLARLPSPFSNNLLKTKNILESFNDLCRNESNLSLLSTKITSILNNNLKDMAKVAGIGSAVSSNGGSVEDIRKSIMDQQGHIDEGRGDGRLDDMQHLVAPLADEQTKANSGSLNVGQLHRQLNISNQLDVNASAGSLQYKAHNNDEGLKGVGEVDDSFVDMASLANSLKYKEYINGGANSGLVISKGSKKWISDADQLPSDGQQGEQAGVMLSTVTSRDFLTKLIMNGNVNTPPPNVADDEEEDDDNSTILDVVDSNNQNQQQQQQQQQQQQQQQQNTHSQIQQYTSNFTGLNLPDLPSFQSHAFQGHFNHQTLLGSFYNGSNAAVGRNSINTIPTSASMLVEAALNSVSNIITEAEISTNNQGQGLHLSHIDPGSGADTDNNLSANSAFSAGNIDESVEEMKLLKSHHFSMQINSISGQYSAQSPADAEIISIRGAGTGTGNSNTTPVGRPKSREKITIYEENEMLSYETPHISQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQLQAGNQQKHLSSSVDSVRSALSPEQTGDFSYSASAAAAAVASGRQQHLATGSPVRSSSRQIYAEHDLISPASTPSLPRYDFGTTDNNYGGTRRPDANKTISSLTLDTFDSNLKGAQHHMQHHLSSDEDNSIVIAENLSVGAAQAEEKLKLAASSSSAASSGSGAPEFIQHPKYGDNNGRTAIVGSSLPGTADMRIKYGNDSTVDMVDFQQRNSIGDSSDFQGLDMSSRTSVAAYHHSNFQLSVQPGSNSPPTPAISYSAHHHPDMIRMVSLDLSSNTGSHHSVNNGSHHASRHASFISSQIQPGDHHRLLAGDQLSVTNHRLLVSDPATHLIFEQNNRLLSDATGQPAPPPPPPAPRHVVSPTRGFGAYHHHHHHHHHHQVSSSNYHHPMKQNIASPPINQHGSSAAAYHPFPTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN20</accession>
    <name>A0A084VN20_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-acylglycerol-3-phosphate O-acyltransferase ABHD5</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Abhydrolase domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">ZHAS_00006788</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26 28" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37455"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:74941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37443"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74928"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37444"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:37132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37143"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:37144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37147"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74552"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:37148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:33187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:33188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37163"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:37164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37451"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:37452"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01014674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN20"/>
    <dbReference type="STRING" id="74873.A0A084VN20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006788-RA">
        <property type="protein sequence ID" value="ASIC006788-PA"/>
        <property type="gene ID" value="ASIC006788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006788"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021950"/>
    <dbReference type="OMA" id="ARDPIMD"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000019">
        <property type="entry name" value="1-acylglycerol-3-phosphate O-acyltransferase ABHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="25">
        <location>
            <begin position="87"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KFB39364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006788-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="375" mass="41934" checksum="A904EED677366E9B" modified="2014-10-29" version="1">MASEVTATQAGFHKATNNSDCSHCAKDRSWFYWWTGSSCDMLRTLEKRILSYLKTPFRGSFVDIGDCVGEADKLWTISLNTNSQNVPLVLLHGLGAGVALWVLNLDALARDRPVYAIDVLGFGRSSRPRFSADPLVVEKQLVKSIEEWRRELNLPEMILLGHSMGGFIAASYALSYPDRLRHLILADPWGMPEKPKDFESNVRIRFWLKPIFAVSKMLNPLWAIRLAGPYGSSLVDRFRQDIVQKFSSVISDGKDISGYIHQCNSQNPTGEGAFHAMMQDFAWAKHPMLNRFGELKSTVPVTVLYGSKSWLLHTNPPDTLKQLGEKSNIRVRIIDGSGHHIYADDAESFNQMVNEACQTVDGDACSPSSVAEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP30</accession>
    <name>A0A084VP30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP007928-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007415</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VP30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007415-RA">
        <property type="protein sequence ID" value="ASIC007415-PA"/>
        <property type="gene ID" value="ASIC007415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007415"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015756"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017964"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021716"/>
    <dbReference type="OMA" id="IFIWYES"/>
    <dbReference type="OrthoDB" id="6234674at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000733">
        <property type="entry name" value="Turtle, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000830">
        <property type="entry name" value="Turtle, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001453">
        <property type="entry name" value="Turtle, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001149">
        <property type="entry name" value="Turtle, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF92">
        <property type="entry name" value="PROTEIN TURTLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="962"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="278"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="369"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="465"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="561"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="657"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="778"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1271"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1477" mass="163243" checksum="42C218DC4C47CD2B" modified="2014-10-29" version="1">MGMCVDPGVFRWCQALSRSRSCATITTPKSTASWETSPYVGQTTGGRKGSSSEKEGERCRSCCRRRQNATINGTDSKAKTVSNYTRSNSIAGDILEDTLHCQQSSSTLLVGLDIDSKVRRNVFDASVRNSDRSLHRLISSFLLVLCFTLGCCTINPPQDAVHITAILGESVVFNCHVDFPGDHPVPYVLQWEKKVSEKGQEIPIFIWYESYPTHSGEGYEGRVSRVPPNSTFGAASLNLTDIRESDQGWYECKVVFLNRPPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSSTVGIFNDGTELRISTIRHEDIGDYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVQFTCEAKAMPGNVTVRWFREGSPVREVAALETRVTIRKDGSLIINPVSADDSGQYTCEVSNGIGEPQSASAYLNIEYPAKVTFTPTIQYLPFRLAGVVQCYIKANPPLQYVTWTKDKRLLEPYQTKDIVIMNNGSLLFTRVNQNHQGRYTCTPYNAQGTQGSSGHMEVLVRKPPAFTVEPDPLYQRKVGESVEMHCDAQEAEGTSKPTIQWQRRDGQPLQKNRVKINNGNITIENLRRSDFGYYQCVASNEVATIVSATQLVIEGTQPHAPYNLSGSATEFSVTLSWMPGYSGGPDYKQDYTIWYREAGVSEWSTIPVTPSGSTQVTINRLSPGTTYEFQVIGKNALGDGMMSKVITIRTLDAQKAKKPSTTTAAPNEKEFKHASDELGPKPGQPRNVTVVEIPNGFLISWQVPLERAHLVQFYTIKYRTDAQWKTLNRGQIRPEETSYLVKNLVGGRTYYFRVLANSLKSYETSEEIKFPVPARVKHKAITAGVVGGILFFIVAIILSICAVKICNKRKRRKQEKELNMVTARLTDRNALSQPIPLRSDWIANGWRFNSFPSLSYRFMQGESKASRLPGLNILIAILHWIWPPGRCQNCDSIYSNKYTGDQAMNVGQIHRAADGRFVLSQDLVDGIVSLRNSIVSQYSSSDDGGFLPKRLPTMTKASWRRPLVSYPSQLSLQIEEGGGGGGGSNGGGGMPQQAQPQQSLYTNTMPGNVMISSVSANVPMMMAAQSLYTTPSRVSKVVASSPATSSPQVVNSPWSPLYFSDLSSVHHLSSAERSFPTPQSMHSVQRYYNHELPVLQTQEQTQHQNLYQNVPPWGYYGGGATGGTFPYSNRPKLFSRYYPRSMPRSLNRTIRELRSPMLNLNLSTTPLSAGGLENSPQSYSSSSGFGSKNTSSNNTQPSAAGMAASANHNLLREWRYLPPYRPPPPPPSLHHAAPLSIGGGRFDNPPYSMSHWLELITRLNIASEKANINNTADVGSVDGHYEFDPSTPTPTASTPTGMMRDDFHHLMTLPSTSSDLLWSATGLAGVVSSLNGGRKRGQSRYDNIDARVQAMKEEFYEYRKRQQLQAVSGGPNVAELESAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPL9</accession>
    <name>A0A084VPL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007292</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015012">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007292-RA">
        <property type="protein sequence ID" value="ASIC007292-PA"/>
        <property type="gene ID" value="ASIC007292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007292"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8601" checksum="EBF1AEB883B9AFAE" modified="2014-10-29" version="1">METFTKRPHPDPLSSRPARSKGLSCFDFDLCESLFIATAWVSSCGDDGRHHYRLRQRANGRPGSDCIPTVGCRFVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPR1</accession>
    <name>A0A084VPR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP009459-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00007339</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPR1"/>
    <dbReference type="STRING" id="74873.A0A084VPR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007339-RA">
        <property type="protein sequence ID" value="ASIC007339-PA"/>
        <property type="gene ID" value="ASIC007339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007339"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021532"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07861">
        <property type="entry name" value="STKc_CDK1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="298" mass="34471" checksum="79FE1481B5D7BBD8" modified="2014-10-29" version="1">MEDFQKIEKIGEGTYGVVYKGRNKITGQIVAMKKIRLESEDEGIPSTAIREISLLKELKHPNIVTLEDVLMEENRLYLIFEFLSMDLKKYMDSLPPEKMIDSELVKSYMYQITAAMLFCHKRRVLHRDLKPQNLLINKEGVIKVADFGLGRAFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILRTPTEEIWPGVTSLPDYKSTFPCWTQNNLASQVSNLDSSGIDLLQKCLIYDPMLRISAKKILEHKYFEGFEQCNIPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPX0</accession>
    <name>A0A084VPX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Tyrosine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007493</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPX0"/>
    <dbReference type="STRING" id="74873.A0A084VPX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007493-RA">
        <property type="protein sequence ID" value="ASIC007493-PA"/>
        <property type="gene ID" value="ASIC007493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007493"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12026" checksum="A97FE99E06761919" modified="2014-10-29" version="1">MVKRDEPCRNLEIPTKPKLVTTRANQSLKSRNVVYPRHHLVCMPFQDRMASLPRQVYSLSTMARSIHSNGSNTKDKLRKIAVTPGTIIQKRETYGASLSQVAYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR00</accession>
    <name>A0A084VR00_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007868</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR00"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007868-RA">
        <property type="protein sequence ID" value="ASIC007868-PA"/>
        <property type="gene ID" value="ASIC007868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007868"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10300" checksum="CEFDE47E3656059D" modified="2014-10-29" version="1">MTTLDIGDSTWEFALCQQSHHIQNPFDGCRSTHHQRYTALQRTAKDHRSGPGISVCMAPGNIVDPEPKTTLLPLRLLLTIKLLKPQRSGGTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR27</accession>
    <name>A0A084VR27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIG-P domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525013">
        <property type="protein sequence ID" value="KFB40421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR27"/>
    <dbReference type="STRING" id="74873.A0A084VR27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007899-RA">
        <property type="protein sequence ID" value="ASIC007899-PA"/>
        <property type="gene ID" value="ASIC007899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007899"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021783"/>
    <dbReference type="OMA" id="IVRCQYQ"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007899-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="22704" checksum="0775BF4F94B8367E" modified="2014-10-29" version="1">MPEHTPAPTPSRAVYGFALFLFFKTLFVMYVVWAYVPTAVFNRLGLTYLPDKYFALFIPILLLVAVTMFAFLVYPSLALAMTPDVDDRVTISDSYTIYRCEHTFPDGQSCNQRIDDACSTGWYAKRRCEKHIGRISSDQQQRTVRVANFCDCPYEAQCLLRKDPEYLPTLRAKDPIPAVSDISVSKVSRTLYRRRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR91</accession>
    <name>A0A084VR91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007973</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525019">
        <property type="protein sequence ID" value="KFB40485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007973-RA">
        <property type="protein sequence ID" value="ASIC007973-PA"/>
        <property type="gene ID" value="ASIC007973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007973"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007973-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13356" checksum="B593B2006997A2CC" modified="2014-10-29" version="1">MRYNLFPKPNKDNVNQNSKSIPALGKLPNDDGEASQRPANRAKKPLYLVRSAKGIRSHHPGLRRKTGNPIPIIENNERDLDIPTCLLWLPCSIGGRHQAAMSLPCSTARLPFQVQGVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRL0</accession>
    <name>A0A084VRL0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MEIOB-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008114</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MEIOB family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRL0"/>
    <dbReference type="STRING" id="74873.A0A084VRL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008114-RA">
        <property type="protein sequence ID" value="ASIC008114-PA"/>
        <property type="gene ID" value="ASIC008114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008114"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021062"/>
    <dbReference type="OMA" id="IYLKFVV"/>
    <dbReference type="OrthoDB" id="9937820at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056880">
        <property type="entry name" value="OB_MEIOB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24903">
        <property type="entry name" value="OB_MEIOB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIOB-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="476" mass="53244" checksum="01EA98AF362099C1" modified="2014-10-29" version="1">MTTGVIVAKRIAQISDDNREFVLAAVIIAKSDPRFFTGTVRSASNGSSDRTSLVARGVLTLTLRDSEKDTINCTIWAKADVITHYDHSFDVGDVVDVQKPQVSSAVSCRSEQYSPTVSSLYWLTINEQSPSSQIVHHEGKQQPELKLLLKVPPVRPEETIPLADIVASGTSCRGETFNVLVVVRAVRPRKEIRINRTNEMKSFREVVVMDQSHTGVVMKFWSESLIKKIDAWVPLTTVLLIADVRIDFNEYYKTVGLTMDRKTIITQDPNVPQVQNLLRHAKNIPIQDVDIVCSLSSGTVDPATISTVMTVQQILDRTEGDLVSEEDQFTALCYAVITRLDLDGSSKTVSQRCVHCRTLLRSQEQSCSKLDCMGHKTPVLEQFFDLSVDLTDHTGTLQGCRMIGATVETVLRCDVKTFLAKTDTQKTELKWMYLLDRCTVRLVVKRRSAVRFQNLFTIVACALADPTEVEAKLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRS0</accession>
    <name>A0A084VRS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013198-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008281</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008281-RA">
        <property type="protein sequence ID" value="ASIC008281-PA"/>
        <property type="gene ID" value="ASIC008281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008281"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016865"/>
    <dbReference type="OMA" id="LTQNVRC"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="213" mass="22090" checksum="4C6F7756D9841998" modified="2014-10-29" version="1">MILPIELPPEVQPSIGEPREGSRSVFRVEYPAERKPGGAGKLTADMDSGSTMAGKTNSDGAMLGSISQHHSLRHHPHHPHPHHHHQLPAVPPQHQLSHPHPHLHHPSDGLTEVSVVDINASLAASAPLISHVSPSPQIIPAAPGTTTMGGTGTGGGGVVGSTSISGHVPGFCNILNASNSSDLQAVAYNSLTQNVRCKSPPTLVDNLKNGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS31</accession>
    <name>A0A084VS31_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008205</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015792">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008205-RA">
        <property type="protein sequence ID" value="ASIC008205-PA"/>
        <property type="gene ID" value="ASIC008205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008205"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008205-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8762" checksum="C4BD4D4A75EA4B9D" modified="2014-10-29" version="1">MGSCQLLSSFRNKLNESDKQDASTQWEVKHGTHRRATERIEAGPNPCRMERWVRKACFEEKNSVGGSLKRRARKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSH0</accession>
    <name>A0A084VSH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008445</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015991">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525048">
        <property type="protein sequence ID" value="KFB40914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008445-RA">
        <property type="protein sequence ID" value="ASIC008445-PA"/>
        <property type="gene ID" value="ASIC008445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008445"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6248" checksum="716E2B53D287309E" modified="2014-10-29" version="1">MDVYLRYSWGHLCLYRLDKDTDQCRSEPARKSTDSHADANGGGNIGQKVPSSSFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT10</accession>
    <name>A0A084VT10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Conidial pigment polyketide synthase PksP/Alb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008562</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008562-RA">
        <property type="protein sequence ID" value="ASIC008562-PA"/>
        <property type="gene ID" value="ASIC008562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008562"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15532" checksum="D5D8C210118B7702" modified="2014-10-29" version="1">MGSVPNTRTKANESQPPGHPPGTLLEALRLYHVIFHGTSGCSELAVVRKAGKIGDKSCARKRRLQRRQTIIKGFRWERVADGMGSLLKGKRLPSHGVFPTSNATGSYLISTGTSSKQRHPSKTNGCRAFASRKQYFKIPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTB9</accession>
    <name>A0A084VTB9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00008778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016291">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTB9"/>
    <dbReference type="STRING" id="74873.A0A084VTB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008778-RA">
        <property type="protein sequence ID" value="ASIC008778-PA"/>
        <property type="gene ID" value="ASIC008778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008778"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016359"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="242"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="351"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB41213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008778-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="449" mass="49296" checksum="1F99D9C252B1904C" modified="2014-10-29" version="1">MFSRTVAADRDREYRGGGGGGGGGRGGGGGGGGGGGGRHRSRSRERRRSHSRSRDRRRSRSRSPYRKHRSRRRKPSLYWDVPPPGFEHITPLQYKAMQAAGQIPANIVADTPQAAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLSGLAQAAGNPVLACQINLDKNFAFLEFRSIDETTQAMAFDSINFKGQSLKIRRPHDYQPMPGMTDNAAVNVPEKFSGVISTVVPDSPHKIFIGGLPNYLNEEQVKELLLSFGQLKAFNLVKDAATGLGKGYAFAEYVEYPTTDTAIAGLNGMQLGDKKLIVQRASVGAKNSNAAVVAPVQIQVPGLSLVGSSGPPTEVLCLLNMVTPDELKDEEEYEDILEDIREECNKYGVVRSVEIPRPIEGVDVPGCGKVFVEFNSIVDCQKAQQALTGRKFSDRVVVTSYFDPDKYHRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU12</accession>
    <name>A0A084VU12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Signal-induced proliferation-associated 1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009064</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009064-RA">
        <property type="protein sequence ID" value="ASIC009064-PA"/>
        <property type="gene ID" value="ASIC009064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009064"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7636" checksum="F17F25FCF7B9FECD" modified="2014-10-29" version="1">MAKLPPGECIDILPQAEASLSQRFPVALSSLRGAKRTTVDMVNRKYAFPAFFKQTPGRRLSLVDKKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUS3</accession>
    <name>A0A084VUS3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001012-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009378</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525142">
        <property type="protein sequence ID" value="KFB41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUS3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009378-RA">
        <property type="protein sequence ID" value="ASIC009378-PA"/>
        <property type="gene ID" value="ASIC009378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009378"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="181" mass="21261" checksum="D56BBB24ED5C7F0D" modified="2014-10-29" version="1">MVSLVMFLKKFYRTLYTEQDFFGPFELLLKLQGFSMRCERQNRCVRIIFGAMRALLFAQYLLWANRFVLALWNASVEPEKALHYSHTFGVLSTMAVRMLVFKWYMADVERLQKYIRRQRAVSPPATGSFRKIINIAMSFQLTGLVDRLAFSSTYRQELYEMPSNVSSFGWPAELLVQRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUZ4</accession>
    <name>A0A084VUZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009432</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017134">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525156">
        <property type="protein sequence ID" value="KFB41788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009432-RA">
        <property type="protein sequence ID" value="ASIC009432-PA"/>
        <property type="gene ID" value="ASIC009432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009432"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="174" mass="18960" checksum="6DC19FE3FB367FDD" modified="2014-10-29" version="1">MHQNKLPPPCGTEGTNAGHREGTMQRHPRRVRGQCIAAAKRSTRIRVPSGLSMSRHSLPPAGPHQHVEFRAQQLCATPLSTRDVVGWQQVSKGSKRVTGANKGGRGRAGLGLGGSIFAQNCPSLSPAPQHGQWWPVLLPLTEANLPSPKPFSYLKLPNPIPPTRPRSACERWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW04</accession>
    <name>A0A084VW04_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009812</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW04"/>
    <dbReference type="STRING" id="74873.A0A084VW04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009812-RA">
        <property type="protein sequence ID" value="ASIC009812-PA"/>
        <property type="gene ID" value="ASIC009812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009812"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017382"/>
    <dbReference type="OMA" id="VNTSKNC"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784113" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="63"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="323"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="608"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="916"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131775" checksum="51691B3FAC229B87" modified="2014-10-29" version="1">MSSAQDRTRLSSLALLVIVVCSAGECREYQNVITVRQAAIFLSLTPVEIKYDVYNCTSEVKLIVGGEAANYGEFPHQAMLGFPQEDDPQKVEFLCGGTLISERHVLTAAHCFAEKNATVVRLGEYDTKLHTDHEVEIPIDGIRKHPHHRNSASYHDIALIRLKTPVKLSKHIRPACLWDSEHRNTTTVIATGFGLEDFTGKPSTVLRKVQLVEYPVEDCAEKFKFLRRFRHGINDGQMCVGSIGDNITDTCSGDSGGPLQVLNFAKSCTYHVVGITSTGNVCGVECNEYQNITLVSGRVAPLQLYSTPIVFTIHNCTHVEQLIVGGEPARHGEFPHHALLGYPKNGMEHDYEFPCGGSLISDQHVLTAAHCFKNKIPTVVRLGEYDTSQVSVDELQINIAGFILHPNYSNLKSYNDIALVKLAEKVEFTKFIRPACLWVTEHRNTPWYIATGFGQYIPYEGQTSKLLRKVKLQEFPTGDCTETYKNDKKLKEGVRDSQLCVGDTVEGRDTCEGDSGGPLHTVNTSKNCIYHVAGITSVGRSGCGIGIAKAIYTKVSYYIDWIEDNVWGAKCNEYQRITLASGRLFPLTIHSEPIRHEIHNCTNADQLIAGGEPARYGEFPHHALLGYPKNDSMGDYEFLCGGTLISDQHVLTAAHCFKFNSPTVVRLGEYDITQVSKDEAQINIAGFILHPKYSNLKAYHDIALVKLADKVEFTKFIRPACLWDKNVPNTSWYIATGFGMYDNIDIKQSSIMRKVKLRVFVHDACKKPYKHDMRLREGLHDSQLCVGDTVEGRDTCKGDSGGPLQMINTPNTCIFHVVGITSRGPKGCGVGKTKAIYTKVSYYIDWIEENVWGPNAENPGIYSSILKFPGGQRLAVRKCEEYQKITLVSGRLAPLTLHSSLIAHENHNCTNVDQLIVGGEPARYGEFPHHALLGYPKNDSTGDYEFDCGGTLISDQHVLTAAHCFKFDVPSVVRLGEYDTSQVSVDELQINIAGFILHPNYNNLKSYNDIALVKLAEKVEFTKFIRPACLWVTEQRNTPWYIATGFGQYIPYEGQTSKLLRKVKLQEFPTGDCNETYKNDKKLKEGIRDSQLCVGDTVEGRDTCAGDLGGPLHIVNTSKNCIFHVAGITSVGKLGCGIGIAKSIYTKVSYYIDWIEENVWGPNAENPGIYSSILKFPGGQRLAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWB0</accession>
    <name>A0A084VWB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009933</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWB0"/>
    <dbReference type="STRING" id="74873.A0A084VWB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009933-RA">
        <property type="protein sequence ID" value="ASIC009933-PA"/>
        <property type="gene ID" value="ASIC009933"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009933"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001680"/>
    <dbReference type="OMA" id="NCYGTAI"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF10">
        <property type="entry name" value="GH05617P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009933-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="33081" checksum="05C63C072DBBC3F4" modified="2014-10-29" version="1">MPNKELIPIPIEDLPELQRMFLRDWPKHETPYNVVENYIKWYRIDCRLKDVAILSLDETWRKSGTFIVQDRFQLYFYSLEDTNCTLIRALELVDWDYSWKIYACHPKHWTAFCEVQEKHSIELQWKSTTETRYMSKEQALCVNIKLPAGVRLGTLSAEHVPTINAMWPNASVGSEFLVKRLILWNETVALFDESSNELLAWCLRAPTGAHALLQVRDKHARKGYGTIVTIAMAKKIANMGQNSYAYVIDTNEPSKAMFDKAGFEKIGTMHRARTVPRKLVEWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX76</accession>
    <name>A0A084VX76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000266-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Chitin-binding type-4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010284</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX76"/>
    <dbReference type="STRING" id="74873.A0A084VX76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010284-RA">
        <property type="protein sequence ID" value="ASIC010284-PA"/>
        <property type="gene ID" value="ASIC010284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010284"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023725"/>
    <dbReference type="OMA" id="WGTCSNG"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="39211" checksum="11CAB738EABB45C3" modified="2014-10-29" version="1">MPEVMCNLRCRAVSLLSLLTGVVLLCYGPLPVRGHGRMMEPPARNAMWRFGFPNPVNYNDNELFCGGYAVQWEQNQGNCGVCGDAYHLRTPRPHEAGGEYGKGIVSRRYVAGQEVEVEIELTANHMGRFELYLCPNNNPRAEATQECFDRYPLYLSGTKEVRFFIPPDSKKKDVFRYRVQLPLYVSCTQCVLQWTYFTGNMWGRCDNGTESVGCGRPETFRNCADISIVSNTGGGRPPLFVGNNNPFLLYYRDFRDPKPDNVYPLIIRDQVCLPTATYRSFIGMEEWCQNNCLRYPPNCPESVCHCPQTCEAIGELQGREGADVYCLDQCLNYKSSCPADRCRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXV5</accession>
    <name>A0A084VXV5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001308-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXV5"/>
    <dbReference type="STRING" id="74873.A0A084VXV5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010549-RA">
        <property type="protein sequence ID" value="ASIC010549-PA"/>
        <property type="gene ID" value="ASIC010549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017266"/>
    <dbReference type="OMA" id="PRQFGQY"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="559" mass="64555" checksum="D6BDDEA01FBDF192" modified="2014-10-29" version="1">MDAHSKLKPTLEDYILEMETRPPDSGQVAEKDVWAQLHQKEADLLLAAELGKALLEKNEELKKQQDKLIDDYSAKVENLEQEKYILKRQLEISSSENEAVILELQADIKQFRQKLEAQEQIMRQMEREKNMLIEELTAQNTRLSNELQKSNATEMQLTAQLQEIKEQCNRRTLSIQDHVNSLESLKNELRMILDKKNELESRLHMTTNERENLSIALNEASERIHILERSTKEQDTKYQMTVQTLDRLERENGTLSERLESFDSQRSLHSELNHHSSLLQEMNGDEEDTGMKDEASQLVLKEAQSVYKQLKTLCQTLRSTHHDDDSGLHSDMSFSSLDNTMASVSMPPQHSVTEATSASMTVNDKFSRGMLSSAADELVHIIMNLDAMQFKTMFEQTRSMLIEQEEELKKKNDIIMQLESKLSVRDVELQSTIEERNQAREDASHSSLAQDETVVQARKDRDAAIERRTKAEIELAKNRVELMQANSQLLEAIQQKVELLQQLEQWQIDMHELIEEQMKNKLIESSTKPQHQQQQSQQSSGGSATGGRKSRLLDLFYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY80</accession>
    <name>A0A084VY80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cysteine-rich receptor-like protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010792</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018326">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY80"/>
    <dbReference type="STRING" id="74873.A0A084VY80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010792-RA">
        <property type="protein sequence ID" value="ASIC010792-PA"/>
        <property type="gene ID" value="ASIC010792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010792"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6819" checksum="C0B29096E9CC4E76" modified="2014-10-29" version="1">MATIFSELQLLRCIMTGKFGCCPKNPVSRCSVASIAPKYSVDSSVGPRIVLRTGVFGYVCLCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZR8</accession>
    <name>A0A084VZR8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00011263</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="11">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01018954">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZR8"/>
    <dbReference type="STRING" id="74873.A0A084VZR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011263-RA">
        <property type="protein sequence ID" value="ASIC011263-PA"/>
        <property type="gene ID" value="ASIC011263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011263"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <location>
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            <end position="263"/>
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            <begin position="294"/>
            <end position="447"/>
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            <begin position="502"/>
            <end position="695"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W006</accession>
    <name>A0A084W006_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">CLIPD6 protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">ZHAS_00011363</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC011363-PA"/>
        <property type="gene ID" value="ASIC011363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011363"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011363-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="100" mass="11464" checksum="B07B6FD7B7D74EB3" modified="2014-10-29" version="1">MAQTTSTPVAFGRWFASVDIRPNITVTVKSSSAAPLATRYLIVEPQRTRQCRRWYEAHPMYDKKDGHTDLAVLFLEHEVQFNGKCLFNRIYKPESGGMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0S5</accession>
    <name>A0A084W0S5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00011663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084W0S5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011663-RA">
        <property type="protein sequence ID" value="ASIC011663-PA"/>
        <property type="gene ID" value="ASIC011663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011663"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019523"/>
    <dbReference type="OMA" id="GHADTIP"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquinone biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="420" mass="46301" checksum="C42B9C8136B6BB96" modified="2014-10-29" version="1">MASHEGGSRPRYNSTTSGQLQEKLATRSVQKHDWNRAVSEAEKIVGYPTSFLSLRWLLSDEIANVALHLRKLVGSNHPLLKTAKTLIYNDKNQQAWGLIVLLVSKAAGHVANIPDMEQDKSAGVLHSQRALAEVTEMIRTSHLVHQGMLNLQSFDNAGNDLSGDSDMIFGNKIALLGGDYLLANACQQVATLRNQDLNMLISSAFRDLAESNYIGERDEQNNPLPTKPHPSAKDFATDVNSLEDLGFGDLEDNTEPMKIDGVVGNPEKEWSLRHILGGGSLLGKSCQGAMMLGGHPEPLQKQGYLFGKHLSLAWQACIDLQPFLLPKLPMGAQFSLVSAPVLFHLEHDETLYEEIEKGRKSVDNIDYTKVYQAVVQGPGVEKTKILMRKHSIAAMKVLNELPVNDARMALQNIILAMQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0V5</accession>
    <name>A0A084W0V5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005990-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0V5"/>
    <dbReference type="STRING" id="74873.A0A084W0V5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011698-RA">
        <property type="protein sequence ID" value="ASIC011698-PA"/>
        <property type="gene ID" value="ASIC011698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011698"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023419"/>
    <dbReference type="OMA" id="ICTDSYN"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="23981" checksum="8FF349C5144D792B" modified="2014-10-29" version="1">MSVEKFDLHKVHEKFTESLAGDDDVYVDQYLEAFKELYKFFQLMGTVFGFVSSDVKEKVEILEKLRAKENAESFLTIRTMMEYERESNLLSKKDYVSGSRTLLRLHRGLDFIQEFLRRLGELEGDGKTNGVCQAAYNDTLAQFHPWLIRKGANVAMYALPNRDQLLDKVCMDATVAIKLLPDMLSVTRDVYNRTQDLYTKYDLHGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1P5</accession>
    <name>A0A084W1P5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013414-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF4776 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1P5"/>
    <dbReference type="STRING" id="74873.A0A084W1P5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011976-RA">
        <property type="protein sequence ID" value="ASIC011976-PA"/>
        <property type="gene ID" value="ASIC011976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011976"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023163"/>
    <dbReference type="OMA" id="MNPLKDS"/>
    <dbReference type="OrthoDB" id="7883086at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031949">
        <property type="entry name" value="DUF4776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39079">
        <property type="entry name" value="FI08034P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39079:SF1">
        <property type="entry name" value="GH11706P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16003">
        <property type="entry name" value="DUF4776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4776" evidence="2">
        <location>
            <begin position="489"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="876" mass="97422" checksum="55AB07C49EE12F7C" modified="2014-10-29" version="1">MAFDSEANGWSDSNNFSLTLFIKLLELTDPKAGDEGTRFKLFLNCGKTSVNASGTLESLNEKKLANIIGLHTNAEQFVRFLNESNVEVTLMRDSCTVGRGQLRLKDTGAIDFDPKRVGGDPVLEKFPLLNENEEPIGLVTMVLRAERNEAPSVESVSEAKINTNDLLYVVNDERRRTREQQDSLERQLLVCNKCNILRSPDDFSCQYELIDGILHSKAVNSTEKEIERIKQKLNDVKLDETIGHRESVSVMGDVSGGKICGLCRGITITGVTCGRTEPSVTESKPSACNKRHVHRRSSEGNLGECKKVKQNLKPSARCCVRCKTSLNWMPEVCRCPKCGHKAQDPRNADNDAINRKKEFPNFTFDDGIASDKTNSPMMSGTNTLVASSNSCSICHIRRCRCVDCAYRTHHSEAGSSMIGTSEILNPGYGTAVRPLTRRSSTVRERQRREGEGLPVRPPSPRRSEQLRRVYTAKQGPKGGPQPTNGKGRLSGAQIRRNYNAFMRKVRQQNKNLYSYRFGRRHPGISVGHKSCMKQDHLVPAHMGWRWNTCIEGIGKRRPGWRPGAVRKPIMQLMQHFLKCYPMDNVPVSGPRGTHHRSPANKDHPADQKPTLHITKQYGEYSITMNPLKDSETLKIATDPYLPCKPIKFRLSKDPRLTKLYMLRDELKKKGLTLCGCRELENCEHRSEREKRILVEEIRRTAKRLGLPLDTTAADMPSRSESELDVEFTPPSAIIRPDLRQPDVIFAETQYCEDDFKLKPSFGKRQDPQNAAGNSKVPASRGSKTTGSRTPGHGKGDGVMHTPTETKAKQPPTRGDGVTRAPKETNAKSSPGSTVQGRKSIPPKGGDAANKGKPPVSEAKSTGVRISVAKAKVAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2U4</accession>
    <name>A0A084W2U4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Pupal cuticle protein 78E, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012463</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2U4"/>
    <dbReference type="STRING" id="74873.A0A084W2U4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012463-RA">
        <property type="protein sequence ID" value="ASIC012463-PA"/>
        <property type="gene ID" value="ASIC012463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012463"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020821"/>
    <dbReference type="OMA" id="THILYFS"/>
    <dbReference type="OrthoDB" id="6343684at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF237">
        <property type="entry name" value="CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759952" evidence="4">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012463-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="14927" checksum="E7D58966B392585B" modified="2014-10-29" version="1">MACSLNAPRFVIAALAAVAVAQNPDADAQVVNSDSVVNPDGSYAWNYETSNGIRAQEEGVGGQSASGSASWTDRDGTPIQLTYVANEGGFQPQGAHLPREGPVPDHVLKTLEFIRANPPKDDPNFNIQALEAEIARLQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W441</accession>
    <name>A0A084W441_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP006047-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00012921</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020274">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W441"/>
    <dbReference type="STRING" id="74873.A0A084W441"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012921-RA">
        <property type="protein sequence ID" value="ASIC012921-PA"/>
        <property type="gene ID" value="ASIC012921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012921"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005885"/>
    <dbReference type="OMA" id="INETAMG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF105">
        <property type="entry name" value="CYTOCHROME P450 4P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="382" mass="44096" checksum="2909841FAFB3A81E" modified="2014-10-29" version="1">MVRGNAISKQKGRTIASNVLHAAIASPLVDPVISPNPFAMLANAPMDQLDGPEINETAMGIKLDSMTMANEYRSRIEGIGTMLLERLMNPWLFEDFNYKLTGLQAKFNKLLQPVHAFTRSIIQQRRELFHQNVRNLGDFSEENIYTNIKQRYAMLDTLLAAEAKEQIDEEGIREEVDTFMFEGHDTTSAAIIFTLLLIAHSPEVQERLYDELQQVALSRTNPEEEFSQRYYNELKYMDMVLKESLRLYPPVPFISRNISEDTYFGDRLVPKDTLFNVHIFDLHRDPAVFPDPERFDPDRFLPENVERRSPYAYVPFSAGPRNCIGQRFAILELKTVLTAILKNFRVLPVTKREEIIFVADLILRTKDPIMVKFEHRPGDHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4G6</accession>
    <name>A0A084W4G6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013031</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4G6"/>
    <dbReference type="STRING" id="74873.A0A084W4G6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013031-RA">
        <property type="protein sequence ID" value="ASIC013031-PA"/>
        <property type="gene ID" value="ASIC013031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013031"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012845"/>
    <dbReference type="OMA" id="QCTPTHE"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="415" mass="48328" checksum="A434825DB5D03F95" modified="2014-10-29" version="1">MYAGSCLDWHLDPADDDVCLLPLITANDSSVIAKEVTFESEYLPPALELPLADFGLLEQEERFRSPVDETEVPLTPNPPSQPRLRNKSEVKLQDAKDKARKAFFSCENCTLIFQCKTQLVRHQLLHHEKDVVDLKCANRLRNRCRLCREQFATVKQLATHLTMQHPRSPVCDLCLTTFHDRATLEWHRKHHLYSVGDSDNRPANGYVCDVCEKRCASSSHLHLHRKVHLEKKPYSCVYCDRTFTSSGNRQKHITRVHTHERRYQCTKCSESFIYARQLKIHRDIKHTSFIDGDRNSGKWVTCSTCNESFPSQVSLRNHQNQEHRKEQRAFVCGHCAKRFKQATHLRNHILTHTGVRAYECEFCTKRFAMAGDLRVHRRIHTKEKPFRCELCPAAFIMGKQLNKHRSTAHHQQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4L5</accession>
    <name>A0A084W4L5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013115</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4L5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013115-RA">
        <property type="protein sequence ID" value="ASIC013115-PA"/>
        <property type="gene ID" value="ASIC013115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013115"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7719" checksum="D2D53F24D4A18AB9" modified="2014-10-29" version="1">MPNSVEASFVDGEKVSKRTLACGPERSCLGSSNPRLAGDNQNSVREKCPKPEVVNSRCEAFRCGMSRVSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Q2</accession>
    <name>A0A084W4Q2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013159</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4Q2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013159-RA">
        <property type="protein sequence ID" value="ASIC013159-PA"/>
        <property type="gene ID" value="ASIC013159"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013159"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013159-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="15426" checksum="4AEF6592232C7756" modified="2014-10-29" version="1">METTTTATPPTTTAATASGGGAVPPPSGSGSPTGVTSAEIPSTTTAVGSAGSGSGGGGGTPTTPAPTAASSSSTTTTATAVIDTVASTVSYHRRPYPDAALKLDEAVRKVLKRLLNSNDFPDQQRINIHKLAEELFKAGKNVSYRDKCYISVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W552</accession>
    <name>A0A084W552_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020489">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W552"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013296-RA">
        <property type="protein sequence ID" value="ASIC013296-PA"/>
        <property type="gene ID" value="ASIC013296"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013296"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013122"/>
    <dbReference type="OMA" id="ICYSGCK"/>
    <dbReference type="OrthoDB" id="7838071at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013296-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="16102" checksum="3924AABA89843C64" modified="2014-10-29" version="1">MMQYNAIKLAPFILRVVVVLCCTASLTAGRIVHRISDFNAPMAEPVRQCRAICLALHLQDEINNIIVTDECTDRPNCFMCWDYCKILHEEKRIVRNLMCSDVICYSGCKTACKYYGDFYRDLKLTSLDSLLPAVGASKEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5Z8</accession>
    <name>A0A084W5Z8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP007985-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013636</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020709">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5Z8"/>
    <dbReference type="STRING" id="74873.A0A084W5Z8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013636-RA">
        <property type="protein sequence ID" value="ASIC013636-PA"/>
        <property type="gene ID" value="ASIC013636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013636"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015746"/>
    <dbReference type="OMA" id="MASMYSP"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF579">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="10">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="36168" checksum="D2CE238108C7F0F6" modified="2014-10-29" version="1">MGISDEGKLPEDIGPHEARPPQGSPHERAASTGQLMGSSGGDPNSPHSDPHSDDGGDDFAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQGHPYNPYLAGASQVPSATVVAPSLPPNPFSHLGFNLRKPFDAASLAAFRYPSLGASHVLPSAYFNQFHRAPPPPLLPPGVGTLYTPSASFQTLLANISAAQRAPPPPAPMPSKPGPGTDYMTPGGPGMPPGAIPPSPTSPPISPTALPPVMPVPQTALPPPPPPPTGSASPPQADRRSSSIAALRLKAREHELRLEMLRQNGHSDILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W670</accession>
    <name>A0A084W670_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010834-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00013663</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525306">
        <property type="protein sequence ID" value="KFB45714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W670"/>
    <dbReference type="STRING" id="74873.A0A084W670"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013663-RA">
        <property type="protein sequence ID" value="ASIC013663-PA"/>
        <property type="gene ID" value="ASIC013663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013663"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006805"/>
    <dbReference type="OMA" id="GDYRRGC"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="155"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB45714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013663-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="724" mass="81712" checksum="8665497E5B629275" modified="2014-10-29" version="1">MASESDIRAILTRALDADEAGRKEEAIKLYGQAVEQILRLDDREKKDKLSKFAKQALDRAEELKGIKYTGHNPVPSASLTPTASNPVVRSSANLASPSRSGPTLAISGSKHAYTSEEKKVLEHTSHINAKVYVPFMDIDLLEKFHFPMPYTDKDGYLELAPKQKRDFVSWVRVSELSENPQLIVGDHADFYSIRQTVVSDCSFVASLAVASQFEKKFKRRILTSIIYPRNSKDEPIYNPSGKYSIRMHVNGIPRKVVIDDYLPLGRYNQLLCSYSSNKNEFWVSLLEKAYMKLMGGYDFPGSNSNIDLHALTGWIPERALVKSSEPDFNADAVFARLQEGLSMGRCLVTVATGELSDAEAERTGLVSTHAYAVLDMRVVDGVKLLQLKNPWSHLRWRGNYSELDAIHWTPELQRTLGYDPKLAATYDNGVFWIDYPSIINFFDVFYLNWDPSLFQYTYCIHQSWSAGVGPTKDAYNVGDNPQFSLTVPAGRGSVWILLTRHITSIEDFRENHEYITVLVYNSGGKRVYYPTDPPPYIDGVRINSPHYLCKIRLDPSSERRYTLVVSQYEKTATIYYSLRAYSRTKFELKQLGPRYQTVENLNGEWKGKTAGGCPNHPLTYRNNPLYRLHVGPADTSDLVIELRGPKVYQVGLELTVASLEDATVTAPFVAEKTGVYRSGFCVLDLANIPAGVYQVRPSTFLPEQESPFFLKVKSTTNVVIEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W750</accession>
    <name>A0A084W750_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005022-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021107">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W750"/>
    <dbReference type="STRING" id="74873.A0A084W750"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014017-RA">
        <property type="protein sequence ID" value="ASIC014017-PA"/>
        <property type="gene ID" value="ASIC014017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014017"/>
    <dbReference type="OMA" id="YFESRAR"/>
    <dbReference type="OrthoDB" id="7735899at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0563">Paired box</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paired" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="25177" checksum="AD9DFE16A56FB608" modified="2014-10-29" version="1">MAEDQAKRRRPVSDADRERIIQANDNGETPKAIASMLGLKLYTVYEILRQYWKHGKVRASKRGGVRNRKLSPAAIADIEKWLDEDCSISLRSIASKVLSAHSISVSTTTLSRLIFGFRYMFTRITTTRQESRRATATELKNYADQFYELPARIADSGIVYISAADFNICLRSSTNIDNCVGIHGGRSATRLSNICNFCQKCGRKTHRIQSIGDYFESRARLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7V4</accession>
    <name>A0A084W7V4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein LOC101996081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014286</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021315">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7V4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014286-RA">
        <property type="protein sequence ID" value="ASIC014286-PA"/>
        <property type="gene ID" value="ASIC014286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014286"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014286-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9792" checksum="952F8441E95A7872" modified="2014-10-29" version="1">MGEALCSRLCSIEHWLLFQLPNAVSVERRDKDVAKEWRKCSREADGYREAQGGVLSSGRKPFTNRRTHQYRLPSARRWLGEICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8U4</accession>
    <name>A0A084W8U4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009839-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014543</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8U4"/>
    <dbReference type="STRING" id="74873.A0A084W8U4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014543-RA">
        <property type="protein sequence ID" value="ASIC014543-PA"/>
        <property type="gene ID" value="ASIC014543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014543"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017522"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="326" mass="37753" checksum="7753397F85E2A84A" modified="2014-10-29" version="1">MSSNEEQQRADSPTVEEEERPPGAGVVPENEIVKMEDVITIDPETTEVDLNHGRIAKIENLEPLTRLERLYLRWNLIKKIENLDHLTSLIELELYDNQITELENLDQLVNLEMLDVSFNRLQEIKNLSALTNLRKLFLCANRISLIENLDHFTSLTMLELGDNKIRKIENLDNLSNLTHLYLGKNKITKIQNLDKLVKLECLSLQCNRLTKIENLDQLVNLTELYLSENGIEKIENLDQNTQLETLDLAKNRVQRIENIEHLGALEEFWMNDNSVSDWACVDKLANNKSLATVYLERNPVASDVNYRRKLKLAVPWLQKIDATLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9L2</accession>
    <name>A0A084W9L2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005116-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9L2"/>
    <dbReference type="STRING" id="74873.A0A084W9L2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014915-RA">
        <property type="protein sequence ID" value="ASIC014915-PA"/>
        <property type="gene ID" value="ASIC014915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014915"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005952"/>
    <dbReference type="OMA" id="EPTYIAK"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000029">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="7">
        <location>
            <begin position="137"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014915-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="336" mass="37844" checksum="713F70C7E5985429" modified="2014-10-29" version="1">MLQVQERLKSLKSLVCEIETERKRIEPNINNMIRLTKMASEDKSPALNHKLKTLYKIGLQDALQEETLIRQALSKIQDIRNIRNERRIQARNAGNKETIRRGALMKMLQISAQTLPLFVSKPGEKIPHLCGSIPADTSYIAKPGDMVAALVKSEEGEENWILAEVVQYVSLTSKYEVDDIDEEQKDRHVLSRRRIVPLPLMRANPETDRQALFPKGTTVMALYPQTTCFYKAIINQLPQTANEEYEVLFEDPTYPDGFSPPLFVAQRYPQQQHTQSISHGSAMVNAAANSGIASSYASPNVAGTNTATITSHTFSAQSVHTKEEPFTDNFHQDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9V6</accession>
    <name>A0A084W9V6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP009844-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00015060</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9V6"/>
    <dbReference type="STRING" id="74873.A0A084W9V6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015060-RA">
        <property type="protein sequence ID" value="ASIC015060-PA"/>
        <property type="gene ID" value="ASIC015060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015060"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013217"/>
    <dbReference type="OMA" id="EIRTHAF"/>
    <dbReference type="OrthoDB" id="9981647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000078">
        <property type="entry name" value="Serine protease H137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB47000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13511" checksum="625D16837DF60DCF" modified="2014-10-29" version="1">MTQNSQPSFFTVTGWGETEKGTRSELQLHVVIPGLDNSVCNSVYKVANATLSHKQLCVGGLNGTDSCRGDSGGPLMRRVSNIWYLAGAVSFGAKVCGTAGLPGVYTNVEKYLGWIEDVTFVDQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAN6</accession>
    <name>A0A084WAN6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015309</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01022222">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAN6"/>
    <dbReference type="STRING" id="74873.A0A084WAN6"/>
    <dbReference type="ESTHER" id="9dipt-a0a084wan6">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC015309-RA">
        <property type="protein sequence ID" value="ASIC015309-PA"/>
        <property type="gene ID" value="ASIC015309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015309"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023593"/>
    <dbReference type="OMA" id="TSHYPFD"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF12">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="10"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="552" mass="60868" checksum="EDEDEE027598866B" modified="2014-10-29" version="1">MANASVEESSPIVTLSELGALQGSTSTTAWTGRKLYQFLGVHYAQSTAGENRFKPPKKVQPWQGIKDATRHGLPCPQMKLISSFQGKAFVPDLEDCLTVSIYSSDLAARRPVMFFIHGGGFHEGSAKNQTAEYLLERDVVLVVAQYRLGPLGFLCTKTDSIPGNVGMMDLTLALEWVQEHIERFGGDPSNVTVFGQSAGAAAISALMYSPKVADSLFHRVILQSAGSASPWVWDTDPVQSAFDIAIEAGLEDSASLEEVEQYLRKLDVWTLLRSFIDLKAEKSVAQGLDHVGGNRLVVGDYHGFLPQTPWECMKEGKIRQHLPMMAGVTKHEGTFLLTTVYDHFKRTGQLDDPAFVKYFLVDAVNKFLGASDSTGALGGYEMRTLFSQKDLESGSFGEMADGLIDLSGTILIKAPLLREAQASARMNPTGTFLYSFDYVGEKTRFGYGNDTSHYPFDGGVHHSDDKLYLFPYPPGNPDALNKEDTEMAKLMVDLWTSFAVDGVPKSDRLSVEWNPMKTYAGPYLHINDPPTVGENFYEEFTVASDEKRLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB16</accession>
    <name>A0A084WB16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015658</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
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                <person name="Chang X."/>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
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                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
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                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
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                <person name="Shen B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1324" mass="151754" checksum="5C5446A33F544B39" modified="2014-10-29" version="1">MDFRAIWIRDRLCKILGVFEPRYIDTVLNELYDELVAFLDDAVLDQRDEHKRILFAYRTFYERLIEEKVTAFEPATAGASQTSDQPEQTQREKKGKKAKENLRVERVRWELAFSSVQEMNKDVSSAAFHILQAAHADHEITGDAGFLGASNDNELVEVTKIVPTSIKTPIVHICFGIIPEEKIDPNVRYVYMVRRLCTPIGTFQKLEDCMAEMPRKVIVGCIRGNLIHNAKEMLERIYRPGVEFQFREPDTKRPRPEKSASADEDESAVVRASSRISVGLIDYSRPSDFRMKAIQAKKLAPSAAMREESALENSSRQSLADTPSSESNLTQTKASESTTGDSDAKAGAPPLQSPSERWSVLLEESKAKVRAGERPQMDGEKTKLPEESPMKQNLETNLEKFIDTLQWTIDHVECAFSLPTQYNAPHQENITVDEDKHKIKVDIARTAFEDLTTLQLEEIVEGWSIYIGKVLRESNEKEPTDSTPMAEYNLWVERELLYNSIIEQLKAPFVIQVFDALKDNQSNIMKAWPDRFRKLKEALSLARENVEHLAMLQNYLEKIKTGDDFKFILSVIPNITIILRHIWTMSNYYSLDENMLSLIGKISFVFAEKVKILINVDTIFKHSASHIHQCATNCATLLQAWKQSYMETRTQIELSGIGSRWEFDKNVLFREIDHMTRISRDMAHIAQVFLDFENIFDANFKAMITDPEEADNTLSKVYRLINHIISVDYDIFASSNLANWEATLDYFHKGVEQVEHEAKVALDRCIPSLRSAELGLELIKNLDRIETRPALAKHLSSKYENIMKQFLAEVGMVEHEFLKHKNNPPLQRNEPCHVGAVFWVRSLLEFIRKSMTAFREFEASKRHGETSLQRTAFGQYMQLVKEFKEYEKDNFQKFTVHGTKTVNSVLKRNILKLDFCDTMIELQKEKKTSKSKKDQPSTRRPSALMAGKDRSRYTNIATAVRWLVNRPEAPDPQLALAQKLVRAARYTPSQVSSGSGTQTPASEFKINQAQLSQKKIPTWREVIGESVLIEYKLKFALNFSYDIFDVINEGQQFEYLGFTLSPTIRMAIMRKDQLFCDVECVSNMVDKYNDIVLNLSTPELMKSLSSLVSQIGYISNDIKARIERLESYAMFELEADKPREVRVAAADVHHPQQQDTRHDSVTPTDGSALGSVIASGRGEDGTDAEKRQKRPKKVSIKETDDSVKPCREYFDALEKDRNAKTIKLLQLYDSIGPILIKLESLVLGTFTGECREMKYYYNHWEKQVFGCFTRFAAKNLEKFMNNLLQNQPLFEVDAILTVPEILMRPSSSDAYSIMINSVKDFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCF1</accession>
    <name>A0A084WCF1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NERD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015952</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022664">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015952-RA">
        <property type="protein sequence ID" value="ASIC015952-PA"/>
        <property type="gene ID" value="ASIC015952"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015952"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015952-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7234" checksum="E95E6EA25A304E54" modified="2014-10-29" version="1">MLGKPSGLPLVLICPKTDANRLKITAPSGCGFGTETSVKIDASRARTSEKMNEEVISESILDGREGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCL8</accession>
    <name>A0A084WCL8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016014</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525336">
        <property type="protein sequence ID" value="KFB47962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCL8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016014-RA">
        <property type="protein sequence ID" value="ASIC016014-PA"/>
        <property type="gene ID" value="ASIC016014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016014"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10786" checksum="3AEB2527E4C00BA1" modified="2014-10-29" version="1">MQSAFRQQRSRRLVAQASWTVKEQDSPEEMSLRIHLVQDLPDECSRTLRGPWEPAIQHNPTPRSRHQRNTMIEPAPGPRSRQLSSERETEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCT7</accession>
    <name>A0A084WCT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005055-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCT7"/>
    <dbReference type="STRING" id="74873.A0A084WCT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016149-RA">
        <property type="protein sequence ID" value="ASIC016149-PA"/>
        <property type="gene ID" value="ASIC016149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016149"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007635"/>
    <dbReference type="OMA" id="HETFGNC"/>
    <dbReference type="OrthoDB" id="6365952at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2010.10:FF:000001">
        <property type="entry name" value="Ion transport peptide isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001166">
        <property type="entry name" value="Hyperglycemic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000346">
        <property type="entry name" value="Hyperglycemic1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00548">
        <property type="entry name" value="HYPRGLYCEMC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784796" evidence="8">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12953" checksum="6EC9C36D95BFAE70" modified="2014-10-29" version="1">MCSRNLVISLALIIALVPLSTVALPHHSIAKRSSFFDIECKGQFNKQIFYRLDRICEDCYSLFREPQILSFCKKQCFTTDYFKGCIDALQLTDEIEKFKPLIKVLNGADPNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF94</accession>
    <name>A0A084WF94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ribosomal RNA large subunit methyltransferase M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017151</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017151-RA">
        <property type="protein sequence ID" value="ASIC017151-PA"/>
        <property type="gene ID" value="ASIC017151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017151"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="20216" checksum="41ABE2225B732F18" modified="2014-10-29" version="1">MHSGVLDRNSASSRSNQPSERQSIFEANSKRRTKNRISLLVFPFPWNLVDFIEFGEPPTPTCAVRDGRYPSNAGYPLSADLFRQVLDGCDGKCGTSQANEGEKPSRITPTGRLLVEEPQEGTRWDGPSQRPEVSRQVRASDAESSPIVQELPHVLCTLPSNRQDFTSVGPSHSADWPGSGTSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGA8</accession>
    <name>A0A084WGA8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017361</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGA8"/>
    <dbReference type="STRING" id="74873.A0A084WGA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017361-RA">
        <property type="protein sequence ID" value="ASIC017361-PA"/>
        <property type="gene ID" value="ASIC017361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017361"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008313"/>
    <dbReference type="OMA" id="EWERDGY"/>
    <dbReference type="OrthoDB" id="6363432at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="41078" checksum="A93EB50E92F5873F" modified="2014-10-29" version="1">MQHEQQEAMEKEIVRDTVGTAAKLDRPPQQQPQKEQQTGLPRIDIPMKQDNTANMAKVPKDMVSSVTTFFSDICKFRKHLKKPVTSAERKKIGRERKARRIRSLRKWLIPKNAIVALHELQGPGMTEFVFSTVDHQTKAEIVINNVKYEAMGSNKNQAKAKVCEKALRDLAISHMNRIKQQQEAKVAIKTEPPTSSPAPTMSETDPDGDWIMHDLEMDSDGDDTPDALPMEHLAAFALHKLFSEWENEGFEVPILKPTGQQKPKPVAPLAGTGTVSQPSIPKVAKTVADLPAGAATYHPTVLLAYMRPQVAFQDLGSVDDPLYHEFIAGISVDGKVFIGRGRSKKLARKAAAIDACKTLFGVEFDSSVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGJ1</accession>
    <name>A0A084WGJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006608-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017338</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGJ1"/>
    <dbReference type="STRING" id="74873.A0A084WGJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017338-RA">
        <property type="protein sequence ID" value="ASIC017338-PA"/>
        <property type="gene ID" value="ASIC017338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017338"/>
    <dbReference type="OMA" id="HVRDWEF"/>
    <dbReference type="OrthoDB" id="3246549at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="698"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017338-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="751" mass="83310" checksum="44CA3F10E3B9A95B" modified="2014-10-29" version="1">MGGSVSQVFRSGSALLSNRDGHKVSETTVEKVNTIYDALRANPKISIHRLEPLLLQIPKYENILAIHDETGYNLLQKSVGLNHVELARWLLQRHRPDVNRSSCSLPLHIACLKGYEECVELLLKHGARIDTEARMCFPGAHSHNCEESGKYKNQGDDVVCERPNTKLQNAVCYAIDGDQINVLNILAQKMEEPWMPFRVRKPLLHIACERGAWKCVQHLVQTRSDEINLIKDEYYPIHQAVLHDGRFLELLIQHGAITTVRTCTQQMTLLHVVILAARKSAEDTLTTIRILLERGCKELINSPDSLGNTPLHAIIVRYALEEARYGYDKWNKWDVLHLVRFLLQNGAKSSINQAGNSALACVFRHIRDWEVCYELLNMLIKEGGDPNIVGRDGSVPIMVCLVPLINKDPLHHFTHSMKVCYLNCIRILLQNGANPNCSYRSNLTPLHVLIFTVSENFTLNCDIQKRTNFDFIKNILLLLLQYGLDCNITTQHILQSVIDMIVNVRTCPDILCVYELLLLLIQYGTDPNISLSNKLMANGASSASSSIIFVNDFINFGGGIRGAPGGGGGDAAPAGGAVVVGGNGGAGAVGGGGVGGNGGGAEIASGSGGGGGPGAGPASASGSENLRSSFRNNARSYLLFYYIMLITRKEFILLDREQTYQRIIYLFYYSMKHEPLFNCLKTLHNLLIAQVPHRSIDNLRHLIITLYKKPRSLKQLCRVCIYNSLGKKLAPNINRLSLPGPLKEYVMNFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH02</accession>
    <name>A0A084WH02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017698</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017698-RA">
        <property type="protein sequence ID" value="ASIC017698-PA"/>
        <property type="gene ID" value="ASIC017698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017698"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9648" checksum="9E1BF05F433C4DC4" modified="2014-10-29" version="1">MIPSSIALLEGLAKDRRESDDLLESTVSVPYRFSYLSRFSPHSVLSLQHSVLPRHESVNSDGNYLPTREREVLYVGKTEPIKASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHZ3</accession>
    <name>A0A084WHZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP012266-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHZ3"/>
    <dbReference type="STRING" id="74873.A0A084WHZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017858-RA">
        <property type="protein sequence ID" value="ASIC017858-PA"/>
        <property type="gene ID" value="ASIC017858"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017858"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003284"/>
    <dbReference type="OMA" id="QESWHIR"/>
    <dbReference type="OrthoDB" id="8092994at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF424">
        <property type="entry name" value="CALPAIN-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017858-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="153" mass="16424" checksum="EC0AAC15DC4A3908" modified="2014-10-29" version="1">MAGDGGPKLRGWTNGAMQDHQSTLSRPRSAEVITANGNGNGTLPNGRHVNGVVTRGPGGLHEDLEFPPTPRTLSKKKQIVWMRPHDMCGRPQFRIAPPGTPLTARELPEPVGPGDPSLLAALGCLSQLPRLLERVVPPEQTFDTANGYCGMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI96</accession>
    <name>A0A084WI96_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Miranda</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017974</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI96"/>
    <dbReference type="STRING" id="74873.A0A084WI96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017974-RA">
        <property type="protein sequence ID" value="ASIC017974-PA"/>
        <property type="gene ID" value="ASIC017974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017974"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007578"/>
    <dbReference type="OMA" id="RYLEMYE"/>
    <dbReference type="OrthoDB" id="419631at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="114666" checksum="61C2B9C160335919" modified="2014-10-29" version="1">MGNGQLALRTGYELGSHKLKCRKVARLALKRVLLTSVQTSGSTRLKDNASDVVRTIKAKAYTIHRAAVSSPSAFAEPKEKDVPKKSKKEDKIKVGGSMDAESIKTTRSALSLFRTPSLPRRLKFKHISDLTPKKASGKEEKVNRLATEDSLKPSSGASGEKCIESGISKLPPIVQLYNKIDVNKEALGKAREENEELKGKIRELRAEQYRAEVERLNLLAEKDHQIELLERELTSITKADELLQNIAEGCLEKVKEYEREIQGLHQSYEKQLCEMHDAKVELEIRYDELLESHRLLRDDLDVMEGENLFLNEETVALREILEATDMELQRKGDEMQAMQDSLDELIVEGRDLKEQVRYLKAQAEEDMMRYVEEGRNTIREIDQLKQENARLLASLSERDAIVAGMQEELNERQFEMDDLRADIRNEFSKELAATVKKYEQQIATMTELNEMKIRECESIFVLEKSKLIKEHSDRVKQLEQDHLREIERIGEQAEEKIRIADIQNEERVKALELSIQGSISAALASEKQHWQKELDKCQKIAETEIMQCEFEKRDLRTLWEASNEVIKDNECKIAELERRLQLELQVPGGKSRDELEAELRELALECSRVKTEKYNYQLTLNNTRSTVNILMERLKKSDSDVELLKAELEQVLRNKTDMETDNNKLREEITEYQRVLGALRASSSLLEKEMREKEVVFEKLMNSEEDAILTVSQIGKLFSDRMEAGMGRYLEMYEELKKKHDAREAYIQDLKALLDEFANGIELARIELDTKDKKIFELENENKNIKLENMTFRFKCEQFEKYNNQNENHSPQSSSEVQPEDDERLVPNFLIENIINQLEQEGVCSTVSDNSALETIHELMVDGNELSCKSVINDKLKQPEQTLRIAEDNGKENQNNRQNVKNVDSSKDQQQLKAKIAKLQELNRKQENTIINLQQQLSSFDSPQKLNTSSKFLSATASPKTPKKMIVSPFPGKENRSPAQVGVYSPRTNVLRARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIL6</accession>
    <name>A0A084WIL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP011908-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018109</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023937">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIL6"/>
    <dbReference type="STRING" id="74873.A0A084WIL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018109-RA">
        <property type="protein sequence ID" value="ASIC018109-PA"/>
        <property type="gene ID" value="ASIC018109"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018109"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017803"/>
    <dbReference type="OMA" id="QCSTDNF"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785013" evidence="4">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="153"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018109-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="42233" checksum="2C579D37E9FDBC47" modified="2014-10-29" version="1">MKCVLLVVVVLLLVAFQTRADWFDSCDRQFQLTNIADVTLNSPFFPSNYPAGSSCRFVVRAPPGYTIQASCTLNMGNTGSCTTDFLYISTEGFTSPVGSEYFCGKGTVSRQSLFNKLTISYISASSTNSGSFTCRLVVQPQACDCGWSKETKIVGGSEASINEFSSMVGLLDTLTVNVFCGAVIISSRYVLTAAHCTKSIPSVSRVQALVGDHDYRTGLETPYSAIYNIEQIIIHESYNEQTRDNDISILKTTTEIDFNRAVGPVCLPFAYNSYDFGGLLIDVVGWGTTSFGGPMSTVLRKATLNVVPSGTCTAPYINAQKICTFTIGRDSCQYDSGGPLYLRGSQRLYTVGIISYGSACGAGSPSVGTRVTSYLNWIRQKTSEVSYCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK90</accession>
    <name>A0A084WK90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018666</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018666-RA">
        <property type="protein sequence ID" value="ASIC018666-PA"/>
        <property type="gene ID" value="ASIC018666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018666"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14229" checksum="9FA735DD3691F7F7" modified="2014-10-29" version="1">MFVVTLPFINPLPASGNRYRVEREFSSVSAKRQARCKVNATREVLDAASAEREMNGARFHCLIASHALAGSVAKSSTVERWRACEASVGCTSGPARQSGCCSQRVRLPRMVAFWPQHGPQHTHGVSEFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKK6</accession>
    <name>A0A084WKK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018797</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018797-RA">
        <property type="protein sequence ID" value="ASIC018797-PA"/>
        <property type="gene ID" value="ASIC018797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018797"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009058"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="233" mass="24427" checksum="4FD26A37C64B52CE" modified="2014-10-29" version="1">MERACIAAAAGRHPERSEVQVRFCPPASSARATQTSVSPFNAFTPTAHAFTSDAPYAASAPYGQLMPRAMPEQLRPRASFTRSMAGTPAAESTIAPAPTLPRTMDAATRMPGRSTIYGSQVIAVPSQAADPSASRVMTGLLLDPVFAFDMAGPSATQMMAGLSVNPAMANPMMADAATYAAMAAPQVPAQGQPFNAHLGDIGTQPQYWAPATPQMPTHEQHFTAHPGHHNTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKM4</accession>
    <name>A0A084WKM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005564-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018817</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKM4"/>
    <dbReference type="STRING" id="74873.A0A084WKM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018817-RA">
        <property type="protein sequence ID" value="ASIC018817-PA"/>
        <property type="gene ID" value="ASIC018817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018817"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005945"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016995"/>
    <dbReference type="OMA" id="QGVYQTS"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="8">
        <location>
            <begin position="657"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018817-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117766" checksum="0C891B849EB7B95D" modified="2014-10-29" version="1">MSSSPEMQHHQQQEGGAPLSVDLKSANADGTPSPELATMTNVSVLDLHKDYNGGGGGADGGGGADGGGGGAGGVGVTSPHIVHDGATDMSLPDDGTTEKVYDKETNTVYVYTTAAGAGGGHKLTTNAHQHQLTTIVHGQQQQQQQQMGSPDQMHQSDHHVVNEQNLLHARLIQQQSVEEQQHLQRMSPVDPHQQHHQHQQVHPSEGGIIDGHRMIPATLEANDQHQHHLERLSPEAHQHDGVRLLEDSHIQRLLGNQEIISRDIINGEHHIITRNEHGETILTRIAISTAEQLLSRMDNNIIYTTTTPGGAEKHQPSNQQHAHNHHQHHQQLSPHQPQTIYTTAGPVSDTSPQVKPIVYTIGGGEPKNVIYGDPKAAMPHFEAAGGGNSSGGGGGGGGGGPGSVDVEKPQIDYVYNEGNKTVIYTDQKGLESLYANNELGLMDGTQIVVQGNLQYTQQQGPDGTTVYVVSSDMNPDDMTGLQASQGGSTFITEPYPYREYFENQTYAPPRNMYVTAADSEGPPPATTYEGRFNKTNYKTITSAGLTVDLPSPDSGIGADAITPRDQNNVQQQFDYAEPCQAPIGMLDPNASGHIPASVASLQRNLVVNGSQQSPTTSLGGTTAVAVAGAAAAPRSRPWHDFGRQNDADKVQIPKIYSDVGFKYYLESPISSSQRREDDRITYINKGQFYGITLEYVHDPDKPLKNQTVKSVIMLLFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLAGCIEEVSHNAIAVYWNPLESSAKINVAVQCLSTDFSSQKGVKGLPLHLQIDTFEDPRDTSVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVVERSEFYGMSDMIKPPVLFSPSEDIDKLTSMDMQFYGHDADSLSGTSDNVKSPFLLHANKPATPALKFHNHFPPDVPTDKKDPSIIMDASLVANSMVDFSPQIKRQRMTPPLSERVMLYVRQESEDVYTPLHVIPPSTVGLLNAIENKFKISSSRINTIYRKNKKGITARIDDDMIRHYCNEDIFILELQRYEEDLFDIMLTELPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKN8</accession>
    <name>A0A084WKN8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018832</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKN8"/>
    <dbReference type="STRING" id="74873.A0A084WKN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018832-RA">
        <property type="protein sequence ID" value="ASIC018832-PA"/>
        <property type="gene ID" value="ASIC018832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011429"/>
    <dbReference type="OMA" id="DANMGMA"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="7">
        <location>
            <begin position="258"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="751" mass="85367" checksum="8D7E99129FEF1559" modified="2014-10-29" version="1">MSKKEAENACFWLSNQSTSKMDVLTPHKMVVVFLIQEYMRLKKSPDSGTTEEQPPAIELSYADRKRFCMLLLKLIQYPDMPYKDLHGLLVSPTYGLHPVHLEEFTKLMKLLKSVGIDVLFDLYNDIDKLIMDNSVLIGIVGLHLRKVFVTMDKMNFQEVMELYQATIAYYDKGMEAMEAEKHEASEIEASLQHSQYKPIEPCDHGTFAAKWSVKQSELFVAQQTALLKENEVKALPPNELQERLDEIIHDRPQYSQAYFLQYLNNLRVRDVNNAIQALHRSFDRGTTASSAAVANGGSSVPAASESYTKEYQYCNLNLAILHSHFGHQQHALKSLQECITLAHDNGDLTCLHLAQSWIARLNNHDTPIPEKNSSISAIHATSLGVLAGLQSSCRAGDAVPSKLFGLLMLNDHLNCQRSMMDLVANGTAVRAALWTVYGKHEMASLCAQILMNADLKSLDKIYNGEGICQVICTIAVRLAFLGEFNLAIVMVKHAKDRFPRYPHTIAWSVTDHYITLTRAIYRGHWAEAIGECQKLHSFDKPLALLQFAHVMLAKLDITTAKTIILRLLKNSDALEPLIHVRALILYANTFMPAHHAGALSELGKAQDLARKYYLEYEDAIIDLHIGYIYLVHMHVPRQALVPLKSCLETILANGPIYDKSRAIFTFARALVEAEEKQNRLEKLVTLMPMLEEAMENFEKLECYSKAKDMYIYLAKTFHSLGQHDEQNRFAYRYRVLQEQFPTELQYLNIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL39</accession>
    <name>A0A084WL39_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006183-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018972</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL39"/>
    <dbReference type="STRING" id="74873.A0A084WL39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018972-RA">
        <property type="protein sequence ID" value="ASIC018972-PA"/>
        <property type="gene ID" value="ASIC018972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018972"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019709"/>
    <dbReference type="OMA" id="YLMRFIF"/>
    <dbReference type="OrthoDB" id="8400687at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785019" evidence="4">
        <location>
            <begin position="29"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="404"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018972-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="499" mass="56211" checksum="20499D245F39F957" modified="2014-10-29" version="1">MPSRNALWTWIKLLGLALTVLDLALVTAQSNSPQTCPPGSDISPCLCQVKKNGLDILCEATDVQHITKAMSALKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLATIEETSLSSLGRGLTQLDVSQNQLMTVPTSALKNLHYLLILNLNHNRISQIHNRAFEGLDTLEILTIYENKLTLIEPDAFRGLDKKLKRLNLGGNDLTAVPQKALSMLDNLRKLELQENRIKTIKEGDFEGLENLDSLILAHNQLTEVPARVFFHLTLLNSLELEGNSISYIAKEAFEGLEENLQYLRLGDNNLHIIPSDALRPLHRLRHLDLRSNNISVISEDAFVGFGDSITFLNLQKNDIKVLPALVFENLNSLETLSIQNNKLTRIPEEVMEPIMDSLRVVDIMDNPLVCSCELVWFPNLLRDLKNRDDEMTQKKRPMCTMPNEHREYYVQNMPLERMNCVGKKYHTSSLSGNGAPCKVTLMTSLVSFVTGTALIGHGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WME9</accession>
    <name>A0A084WME9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019843</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WME9"/>
    <dbReference type="STRING" id="74873.A0A084WME9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019843-RA">
        <property type="protein sequence ID" value="ASIC019843-PA"/>
        <property type="gene ID" value="ASIC019843"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019843"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013929"/>
    <dbReference type="OMA" id="QGNCWLY"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000111">
        <property type="entry name" value="Solute carrier organic anion transporter family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019843-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="698" mass="76638" checksum="821155C5B213D65A" modified="2014-10-29" version="1">MNGSLANGLNEGLNAPPKKIAFDRSVSAYSERDVQCGFWVCRGPLWQRLASKKLYVLLFGVIGCVFQSTTSYFYGTLTTIEKSIQISSKTVGIITAGSDLSFVLASLFLSYYASNRRKPLWIAMGIVSMAFSCFVNALPHFLFAPDRDELEQSLGNWTQTKATDNLCREDRTPPDCSLDLGNMKPQMVLFFASFLSGIGTSLYFTLGLTYLDDNVRKEKVPFLSSLAAFGRRMGPLVGFSLASLCLRYFVYPGVDPGYSSSDPRWVGAWWMGWLVLGSTLLFISPFFASFPKVLPRTAERVTLSRQASRASQANSTAGNGGPDYVVEEEEDLDKKVSFSDMLVTIRRLVTNKAYVFNNSASIFYFFGYMPFFLFQAKYIEIQYRLTPSQANMVTGSVSLVFSALGILIAGFVIQRLRVTSRQLAGWNVITSILSAAGIVGYAWFGCSALNNADIVANSQNASCSLNCNCDFVKYAPICGSDGQTYLSPCHAGCQDQFKTILGTMMYSNCSCIPGPVGDGEIFTSTFGSATPGSCPVDCWTPFYLFLIVMCANKFIGGTESAANFLIGLRCVEPRDKAISMGFSMAINTLFSFLPAPIIFGAIIDRTCVLWGRTCAKQGNCWLYDGEALRASMNYTAAVFVLIGTCFDMGTWYYSKNFKIFDDAPGDTTLPDGPLVEKEMVALVGKDKERSTLSDGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMK1</accession>
    <name>A0A084WMK1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019926</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024475">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMK1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019926-RA">
        <property type="protein sequence ID" value="ASIC019926-PA"/>
        <property type="gene ID" value="ASIC019926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019926"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7579" checksum="E77C37E26493DA3B" modified="2014-10-29" version="1">MEVLDVKKPGRAGGPLGHTRKLVCAPSRTKLSRTCTDAGRGKVSHFDELSKHVTGTVTGFQRTETKIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMN5</accession>
    <name>A0A084WMN5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019535</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084WMN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019535-RA">
        <property type="protein sequence ID" value="ASIC019535-PA"/>
        <property type="gene ID" value="ASIC019535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019535"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000958"/>
    <dbReference type="OMA" id="HIDFWND"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="412"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="536" mass="63753" checksum="49404E85AEF8BE9C" modified="2014-10-29" version="1">MWGDHGEKAAPFYISRRELEALNRKTQLENVIELEKIKKRRLEREHQQQQREDDMYLMQRSKEAAQFDEWQRQEESFHLEQAKLRSKIRIQDGRAKPIDLLAQYISEQNLEESIEMQMHEPYTYLNGLGLDDLEDLLVDIKVYNELEKGKNLDFWTDLTIIVDDEIHKLRKVEAEKQRIATGRREGIHQSVAKDVTEIFRGKTAQQLDDLKKKIEEKINSQQDGLDIGYWESLLSQLKAHMARARLRDRHQDNLRSKLELLKKEQEIQIKKEEQTDDEEAGPSGMGSKTAEQADESSMDSAAAHSESEVPSKASDHHETDLLDECFEAYKKGGYEPKYLQAADIEHGIEIITEEKDEEILDTLRQKVLGINQEEELYSREEMLLRKEARRGMDHDEAEFSVETRVDSQVYLWSDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQGYKFNIFYPDLINKNTTPQYFLTPCSDNGDFATLRFHAGPPYEDIAFKIVNREWEFSYKRGFRCQFQNNIFQLWFHFKRYRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN00</accession>
    <name>A0A084WN00_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006777-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019666</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN00"/>
    <dbReference type="STRING" id="74873.A0A084WN00"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019666-RA">
        <property type="protein sequence ID" value="ASIC019666-PA"/>
        <property type="gene ID" value="ASIC019666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019666"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019524"/>
    <dbReference type="OMA" id="FQFAHAN"/>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18318">
        <property type="entry name" value="BTB_POZ_KCTD20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="105"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="431" mass="48112" checksum="9928F6717F0FD3FF" modified="2014-10-29" version="1">MELQLQRKQGTPASGTLQQRGNDSAAGNGTASASSANGAIGKNDSYDSSHSSSNTEDTTETDDRRRKMMKNRARNNRLMQQQHQAQQNTTDSAKVAAGKKLADGERITLIVDNTTFSVNVSMLTAQPQTMLGRMFGSGLEFTHPNERGEYEVADGISHTVFRAILEYYLSGVIRCPPTVSVQELREACDYLLIPFNADTIRCQNLRGLLHELSNEGASIQFEAFLESLILPLMVDAARQGHRECHIVVLSEDDIIDWDAEYPPQMGEEDCQTVANTAMYRFFKYIENRDVAKQVLKDRGLKKIRLGIEGYPTYKEKIKRRPSGRMEVIYNYLQRPFIHMSWEKEEAKSRHVDFQCVKSKSVTNLAEATADPALELDSAGNPLPQRHFEISHEPDAEPFMRNPDALLDGEEGAIGGLANADEIGNLGPEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN55</accession>
    <name>A0A084WN55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019728</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024567">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019728-RA">
        <property type="protein sequence ID" value="ASIC019728-PA"/>
        <property type="gene ID" value="ASIC019728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019728"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11740" checksum="F836CBE3AF3896B4" modified="2014-10-29" version="1">MASKPLKLGHISKSVGKQAIVCRVQSKVSKSIVHSRKAKQTASLQQAAVKREPGLVPVSSVEIDLPLENSEPHPARAGFRRANRSKSRFTRSNRTCAIVFDYGMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WND8</accession>
    <name>A0A084WND8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019823</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024590">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WND8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019823-RA">
        <property type="protein sequence ID" value="ASIC019823-PA"/>
        <property type="gene ID" value="ASIC019823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019823"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5452" checksum="4A890F178EC5BD38" modified="2014-10-29" version="1">MVVTSCRQVNRGRSIYTSSSSIKTTTKTTVSRSAGAFNHQRRLCDSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNN1</accession>
    <name>A0A084WNN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Regucalcin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019981</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024642">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019981-RA">
        <property type="protein sequence ID" value="ASIC019981-PA"/>
        <property type="gene ID" value="ASIC019981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019981"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6414" checksum="FACD77F23B564AF7" modified="2014-10-29" version="1">MHRILFPGPGTVQGHDAPHRWPAPARKVCRWGPGSRRRNCFPVRFPIGTTPLLLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNQ6</accession>
    <name>A0A084WNQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020027</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525356">
        <property type="protein sequence ID" value="KFB51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020027-RA">
        <property type="protein sequence ID" value="ASIC020027-PA"/>
        <property type="gene ID" value="ASIC020027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020027"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7675" checksum="9E206B1B6B216BF8" modified="2014-10-29" version="1">MKRCVALMLCLRHRPTAAKPASTQQQAFKPACTFLLLRALVDRSIVRDPVRAVVAREIEWLGVQNASDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP48</accession>
    <name>A0A084WP48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101710489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020187</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB51992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020187-RA">
        <property type="protein sequence ID" value="ASIC020187-PA"/>
        <property type="gene ID" value="ASIC020187"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020187"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020187-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16596" checksum="8AB5449597F5F55A" modified="2014-10-29" version="1">MVALKSHNSTPSAGHFSRSGLSGARGLRNSSFTPVRMLAQHQDRQQDPPPPAYGASREFSNGRERCWSRQSRPSGIFRAESKDATVHQPQGDKLSSPRFARRLRQPVIGSAKINSLSHHEPISPHERTPGAPQLVTLAGGTEGNSRSVNVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ87</accession>
    <name>A0A084WQ87_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004344-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020593</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525379">
        <property type="protein sequence ID" value="KFB52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ87"/>
    <dbReference type="STRING" id="74873.A0A084WQ87"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020593-RA">
        <property type="protein sequence ID" value="ASIC020593-PA"/>
        <property type="gene ID" value="ASIC020593"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020593"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005452"/>
    <dbReference type="OrthoDB" id="10668967at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020593-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="29007" checksum="53969FD72CC8B5FA" modified="2014-10-29" version="1">MYVINPAPGPQDLQTTASSYASAAVVGVTHRTESPVDSLEHQQEQQKRKELLSQILTKCTVDMSEEVANFSSPGEKESSRTVAAAPTEGGTNQSPSAPTVEAAGSPLRSETDESVRNGPVEATANGAAENATRGTPSPASLRAAVSPDRSPARSTASSSNTSLSPTSLTETTKASDAGEQPLSAKPTPVSNFASVVHPKERALKSIAAAAAAAAAAAAASNVPSPTSERHHSSTNGADGATAPVGKVKPPVASGGRALLNGANCISPGNITGAGAAVHGGRLQFFKGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQH7</accession>
    <name>A0A084WQH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020713</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025622">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020713-RA">
        <property type="protein sequence ID" value="ASIC020713-PA"/>
        <property type="gene ID" value="ASIC020713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020713"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12372" checksum="851A545F2FCD97AD" modified="2014-10-29" version="1">MRCNEAPSETADPYYHYYTGAPVGVLQNVVKSRTRECPFGSFLPSPPLSSPRLQRTPGKKNLPPSDRPPDRPLGCKKARKGHRAAVAAGKWITTEMALKDDDDDDERRVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR07</accession>
    <name>A0A084WR07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020952</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020952-RA">
        <property type="protein sequence ID" value="ASIC020952-PA"/>
        <property type="gene ID" value="ASIC020952"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020952"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020952-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="14010" checksum="69F42824F77FF7D0" modified="2014-10-29" version="1">MTQGVASIVREASRYFSTLLASSHLGLASPIALNGTVVVCGDGTPSARMAFGGGAWWTSELIICINLRLTKPAAAAAAKLLSEGFNFPFKCRRGFVRLPKFSRHNVEHLLSVLRGMRIRLNDTHLAAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRR2</accession>
    <name>A0A084WRR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021185</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021185-RA">
        <property type="protein sequence ID" value="ASIC021185-PA"/>
        <property type="gene ID" value="ASIC021185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021185"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021545"/>
    <dbReference type="OrthoDB" id="10070859at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37002">
        <property type="entry name" value="AGAP007005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37002:SF10">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021185-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="561" mass="57240" checksum="DB32F6B732941679" modified="2014-10-29" version="1">MLKPDAHPASGSNVGDLHLAAATSSIGQPSSTAQLQHHRWLHRKSASTCLVVAQGGTQTADDGRPGQDAVDPIARTPVQPGDEGGEKEPVEPCALLSGLSSVRQANGEASSSSSSSLSLAPSWTTTSGSAQKDRAVVVVDVASSGGGGGTEGSYGRSFPEKRPEVMRLNVPAAGLAEGSRTSVYIPSSQVSTSGADGGSGLQALTIQVNRLDPNNQQQNDVVNNPSSGVSIVSCYRAAASVGQSGDQSVGEEHPSGLKSSGVQTQPEGSVRADIGVRGEQHHVLEPVLVGGDDGRVTGGSVVLEKSAVNTSVVNSTGSAEQMVQVSSGPEWPTVRGKAEESPAPAVVGEEQKEAGGGGGVSSVSAGPGAPPRTYTSTEAQTDDTIQVQPQPLQQAPVLQMHAGAVAGVGPYGGPDPTTMLGVHVGGALLMGASPPALGAVPGLPPGGSEFSTREHRRRERRERRMARNRLQHIHPLEPPPPPGGPGLHHRSPPPIEIIPDILHSHLPPPYTTLPMGASLIPQMIPANSAAAAAAAVAAASAIPVRAADDCRYTFPIPIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSE6</accession>
    <name>A0A084WSE6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008309-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSE6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021515-RA">
        <property type="protein sequence ID" value="ASIC021515-PA"/>
        <property type="gene ID" value="ASIC021515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021515"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004707"/>
    <dbReference type="OrthoDB" id="45313at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070073">
        <property type="term" value="P:clustering of voltage-gated calcium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007270">
        <property type="term" value="P:neuron-neuron synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032751">
        <property type="entry name" value="Fuseless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35270:SF2">
        <property type="entry name" value="FUSELESS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15993">
        <property type="entry name" value="Fuseless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021515-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="281" mass="31645" checksum="37E3F2DB7A5BF736" modified="2014-10-29" version="1">MMSTRDTESVEERSPLDEQSSPFGPVVVVPSREHRSTPGSGGRCRKRLLHFGDTLLSLFVITPLAVAHWRGTWGYMDLHRPHFPGWLCFVLGATLHTTFALLREPLNAGLALAQSAPRSRTGTIKRWLVNRLYTYAFSMGCLMHWRGGWEVMVSYFAFNPWPALTVSAICLIGLVLLKSVRNLLAPPFVILTDRKEAMFSFPTRFRMKVNICSTIKSITKQDRRPRERTVVLGMAVRCSLFGSSFVRCSRGTLKLLPDIDFVLGEMMMLMNGSLSCVTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSM0</accession>
    <name>A0A084WSM0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00021521</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="ATLV01026618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026620">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026622">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSM0"/>
    <dbReference type="STRING" id="74873.A0A084WSM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021521-RA">
        <property type="protein sequence ID" value="ASIC021521-PA"/>
        <property type="gene ID" value="ASIC021521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021521"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009284"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="381"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB53214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="863" mass="98042" checksum="24EEC8F0C79B960E" modified="2014-10-29" version="1">MIHPLQIDGLRLESFLNSNLERTPFLRKTLLKEGVFGVSNTRVPTESRPGHVALLGGVYEDPSAVFKGWKENPVEFDSVLNRSSVSYCWGSPDIVNMFSHGAIKGRVHTATYHSGREIFSQTANTSLLDIWVFDRVRQFLVSDEARKEVFSRKKVILFLHLLGMDTAGHVYKPHSKLFSRNLMILDKGIESIVQLVERTTGSDGRTAYIFTSDHGMTDQGSHGSGHPLETETPFLAWGAGFGHWKTTHSLQQKQRDVLELDGNQIPVHQIQQADAAPLMSTVLGIGVPKNSIGKLPRAMLNVSEEYGAWAMRNNADQLLQQYYRWQKETEGKMLQWLTLPKQTNLKDEINNLLDKIETATTRKDYVEVQNLTETLMDVTIEAIQYFQSYYKPHLFLSLTLTMLGWLLILAKETFVVSINDSSAVERTKTRTVTYLALSFASIVLIVNIAQNTPLPIIIYFLVPIALWGYIGGKWSTFKTLFKWNAFVNYFNFVCAVEALVLGFLYRMPLVPLLLFHSVLLMKSHYPQNHMEWGWITVNVFLGSFLLIPVGNTIFANVYSLYASIAIWTVANATILKKSSSLLLFKLFALFMHLLQTANFLFIINCIERSHAVPQLSRTLCWVFSALGILSPFFASSSVTERMLAIFSGLSGPYMMLSLSYEPLFLFCFCFTLYSWIYLEQNHVQRWKPRGTSSSITFKPSGVEDVRRILAFMLFLLTSFFGTGNLASISSFDPNSVRCFVSTFSPFTMMGLIVLKLLIPVLMVVCSLKVILSIHSIPKGRTFTLILIVCDGMCMNFFFLVRNEGSWLEIGTSISHFVILECTTIVVMVLYELARFYLEWKFVRQGSHTKRKPDLPLINKERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU05</accession>
    <name>A0A084WU05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022074</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022074-RA">
        <property type="protein sequence ID" value="ASIC022074-PA"/>
        <property type="gene ID" value="ASIC022074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022074"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14071" checksum="C9186B52B6F5891F" modified="2014-10-29" version="1">MPLKIEIRNGSEKLPQHKAKWEGAVLRRSTKSQRKIVPNRETPPGDETNLGKMPFRVVPGANALGEVRGSQLTSTGSTYEPSRTKDECEIKLLRKVQQSVGTAENTEALGGEHSRPSLLLLRARITTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU12</accession>
    <name>A0A084WU12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022082</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022082-RA">
        <property type="protein sequence ID" value="ASIC022082-PA"/>
        <property type="gene ID" value="ASIC022082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022082"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="217" mass="23545" checksum="8C09F3828EF99285" modified="2014-10-29" version="1">MLGNSHQLKALPTVRVECIALKATPPTGQAVRKAVPNRLPNRGTSFCGATRATYLTGLGQTALTQQHFPLSVLHCLFNAREKPGLTCPTPPTPQVNNCHPSRHGKIGGSDYKLTTPIAVSWGAARLFGFERASGRHFGPSGWPPGKMVCVACVFQLYWVSTNLLDDRGRYCVTSRGRTFPGNGMKPFFNQDHTPPGGHPTCTSGVIFSNHRYATNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUI1</accession>
    <name>A0A084WUI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022319</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022319-RA">
        <property type="protein sequence ID" value="ASIC022319-PA"/>
        <property type="gene ID" value="ASIC022319"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022319"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022319-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="153" mass="16737" checksum="800871791AB35A5E" modified="2014-10-29" version="1">MARLIRIDRQNLPRGKASSIPCTNVEILTAIYSRKRPAENSNCQLSLSLLIDRTTSSSTHGFVPLKTGSLTGAQETWMARVPVFGSCLSSQDASLALLSVSVAQRSPRMGHVEMKNEKDSGRNRKNPRSRDTACDQMAGPGSSVSWQKVVDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB02</accession>
    <name>A0A084VB02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001067</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524242">
        <property type="protein sequence ID" value="KFB35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001067-RA">
        <property type="protein sequence ID" value="ASIC001067-PA"/>
        <property type="gene ID" value="ASIC001067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001067"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8837" checksum="4CB5EBD7251656EE" modified="2014-10-29" version="1">MQSSHFGHGAVHAWEPGLATAQPTDRRVIDLGVEFLASIPLWPSMVERLGTGGRGPTVVSIISAVCSRASTAHGVHRQFGWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB12</accession>
    <name>A0A084VB12_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00001072</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01004845">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524243">
        <property type="protein sequence ID" value="KFB35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB12"/>
    <dbReference type="STRING" id="74873.A0A084VB12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001072-RA">
        <property type="protein sequence ID" value="ASIC001072-PA"/>
        <property type="gene ID" value="ASIC001072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001072"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003822"/>
    <dbReference type="OMA" id="FSFMPEF"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000916">
        <property type="entry name" value="AGAP003548-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="565"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001072-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="968" mass="108904" checksum="B526ED563C7E5554" modified="2014-10-29" version="1">MKFPWSHTTIVDMIKNDHKVEEKCHKVTADIIAGKLTIAEFVEELGPALTHTDASVRAQGTLLLSNVLKDLPPDGLTGEQLEFVSAFYCDRAKDHNAVTPMVLVGVEALSRMTNLSDAAAVRLLRSMFELITCQSQKKPERTLYFQTIVTLSERKTDALKEWGADFIYGVIGAMEGERDPRNLLYLFEQMPTFIRAYPMHHLAEEMFETFACYFPIDFHPNPNDPVPITRDTLAEKLADCLCATAEMAVFAVPLLVEKLDSSLKVAKLDSLALLGRCLAVLDVKEVEEHHAELWSALKRELFPTGPSSSADKELQEAGYGAMQALAKNASTDESAAKTFLDQILLGVMGSLTDASSKNFEASLQIELACARASSFCAVYVIEKLVPMLLAQLNVDGFVEMRLQNILVDSLQRLMVPCAQWYCWAELDPTLLGQVQKKFIEILMQQPNASEQKRSALKALAAVPEMVTSENRYVVYNTIVNDLLASVDKVPQTDAVEDCLYAFATRNQQEVKTVVLNKLITHDFSTTEQAVTERTFKTLGKLILYHGYMEKMVNFFLSLVFAKPPPADDRLAIVAMDTLTDVVETGNLSQFAKAELYLQYKLLDRFFEYVTDQLTSDYLYSMSRLIAAVVKQLPTDEQKDLILKRLPTLQLQRRSHLYLASGLLGYLDESVPLVDHFESLVNDLSKLALETDDERVRQVCHRLLCSLFNRMPDDDHHRGVLKRLLAVLKAELKKHNHQAVLILGWIGKGLMARGHAEAGEIIDDVAELLDHPTLSHMAALAFEILSLEFPQLHLPLLKSLFKQKLFVWVMKKLEGKMEQYAVAHLKALVFVFKATPHAVLKMNLSKVGPVLLKCLAQDDDHTVVEALTIVGRLIRELDVFVQDHLQSLIPVLLKLVTRQSSMKVRIGSLECLLYICKYPTFLLLPFKQTALIELQKPLDDRKRLVRNAAVAARLQWYLVGSTEEAKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBA5</accession>
    <name>A0A084VBA5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Headcase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00001414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01006235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01006236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01006237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524347">
        <property type="protein sequence ID" value="KFB35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBA5"/>
    <dbReference type="STRING" id="74873.A0A084VBA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001414-RA">
        <property type="protein sequence ID" value="ASIC001414-PA"/>
        <property type="gene ID" value="ASIC001414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001414"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017802"/>
    <dbReference type="OMA" id="HRECFEH"/>
    <dbReference type="OrthoDB" id="10012848at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054537">
        <property type="entry name" value="HECA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15353">
        <property type="entry name" value="HECA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase middle" evidence="3">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="483" mass="51121" checksum="19DF15BDB34BC8E6" modified="2014-10-29" version="1">MAPRRSAGGSVAVGGGQVPSQQQLHQQTTASLVANSGSSLYDPFGWGGASGDSDHGFESSHSADGSGSEGANMTRCCVPVGECLKPKTGNLLADFGAMINVEDLRDCVRVLCSNDSCTVGQYMHRECFEHWEDEILGYLKSIGRARSWSDKQRQQNLWTKKGYDLVYKMCGCKCGRGHLKKDLDWNAPTTASMFGRALVGSGGGGGAGNGGNSLGPIGSGEDESMKKKKKKNRHNQKSAAAALLAISTNATSGSTTSSANSSATNSPNNQMQMVQQQHHLQQQQQHGGGPNHQQQQPAGGVAQNALSVLSNLKISDHFATCLQLSGLNPNGIINNHVIAMSTAAAVATARLRANSLSSISNGSSTPPASASSIGGSEQSISPIHNQPPSPASIAKLPLTPKSKVELYSERVRATSGANGIFSRRLDFSSFNVLPRQRINSYSIKLQRNSGLSPGLCPFLKPLHRVQPRLTSSLRAMENVPWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD01</accession>
    <name>A0A084VD01_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01011083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524639">
        <property type="protein sequence ID" value="KFB35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VD01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002784-RA">
        <property type="protein sequence ID" value="ASIC002784-PA"/>
        <property type="gene ID" value="ASIC002784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002784"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004946"/>
    <dbReference type="OMA" id="VGDITHE"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF81">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="220" mass="24578" checksum="844E567606A357D2" modified="2014-10-29" version="1">MGDLGCVSDADGAIRKFYRNKTVLITGGTGFIGKVLLEKLLRCFEVNKVFLLVRPKRNRTVTQRLEDVFEDVVFDNLKASPGGGKPLLSKVIPIEVNFQADKIISAESQRVLAAEVEIVFNVMASVKFNEDIETALDTNVLSSRKLLLMVEHFPALQSIVXXXXXXXYVTVYYRAVNTLRRSSAKAVSCGKYPSSPERKTLRMFSTCRPSLHCRMCSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDV3</accession>
    <name>A0A084VDV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003199</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011803">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524723">
        <property type="protein sequence ID" value="KFB36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003199-RA">
        <property type="protein sequence ID" value="ASIC003199-PA"/>
        <property type="gene ID" value="ASIC003199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003199"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="10231" checksum="2E4F3A7F9F53E32A" modified="2014-10-29" version="1">MQMMMMMERRPLQRCMLLLKCAATFGQTAAGERKKIFPMCKQTIQPVLRRRDVPNNSIEGSFVVHRLEQNARVGMMIFSIRIGAFVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE99</accession>
    <name>A0A084VE99_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP010807-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00003414</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE99"/>
    <dbReference type="STRING" id="74873.A0A084VE99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003414-RA">
        <property type="protein sequence ID" value="ASIC003414-PA"/>
        <property type="gene ID" value="ASIC003414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003414"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017175"/>
    <dbReference type="OMA" id="YFGWEYN"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="444" mass="50838" checksum="E646C54D38DCF1DA" modified="2014-10-29" version="1">MIEGFGGLNLWVPLDKELVEKIQQLGAHNKQLKCIVQKNLKPGDVANGKASKKRPFDFCKCFKRLILLRFYYLGWDYQGFAAQEDSVDTIAEKPQNYNRCGRTDKGVSAFHQVISLDVRSKFPPEEQLLDENVAAELDYCAMLNRVLPEEIRCLAWMPMVNPSYSARFDCRSRTYRYFFPRGNLNISAMEEAARHMLGSHDFRNLCKMDVGNGVVNFVRSIEEICIRPSQADTTDDRSYDMMYLQLRGKAFLWHQVRCIMAVLLLVGQGKETPAIVQELLDVEKNPCKPQYSMASDVPLNLYECQFNEKSGEPSDRKTDDKSDLREWIYKEDNLSRTISELQTLWTKHSVKTTMIREMLATLHGVFQENFGAARSISNQADSLTQGVRSKEYCPLLQRQRCESLENRIEHYSKKRRIEVSAKSIESNAARTDGSGPSTQTVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEE1</accession>
    <name>A0A084VEE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003460</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524777">
        <property type="protein sequence ID" value="KFB36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003460-RA">
        <property type="protein sequence ID" value="ASIC003460-PA"/>
        <property type="gene ID" value="ASIC003460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003460"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6501" checksum="E21E9BE79BB0F56B" modified="2014-10-29" version="1">MYQCAIDYKGSRLAAALRIARPEASSRLCLCFGVPQEVDLFDRQGFPIGPSRAGGTIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFK9</accession>
    <name>A0A084VFK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">KN motif and ankyrin repeat domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003910</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003910-RA">
        <property type="protein sequence ID" value="ASIC003910-PA"/>
        <property type="gene ID" value="ASIC003910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003910"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="13898" checksum="9E5ABB9234AB72EF" modified="2014-10-29" version="1">MSSSYRMMVGSGGSGSSSSSGSITRQRHRLTNSSSTGTATAPRPAVPSTASCSLPLERPSGVRESSIDAGQPKQSEENLLINHVISWKTGWKLSRQQYVTHFLLECLDTRLPVFPGPIRHLLHRSSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG58</accession>
    <name>A0A084VG58_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004126</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012666">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG58"/>
    <dbReference type="STRING" id="74873.A0A084VG58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004126-RA">
        <property type="protein sequence ID" value="ASIC004126-PA"/>
        <property type="gene ID" value="ASIC004126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004126"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004416"/>
    <dbReference type="OMA" id="HEAYMQI"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004126-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9520" checksum="9574243F4F32A320" modified="2014-10-29" version="1">MGAALDHAWLPGGRELLSTSAGKFCVGDEVSLADCCLVPQVFNARRFHVDLRPYPIILRIDRELEGHPAFRAAHPSNQPDCPPEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGB3</accession>
    <name>A0A084VGB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004183</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524812">
        <property type="protein sequence ID" value="KFB37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004183-RA">
        <property type="protein sequence ID" value="ASIC004183-PA"/>
        <property type="gene ID" value="ASIC004183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004183"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004183-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10498" checksum="C53B73679FE685A5" modified="2014-10-29" version="1">MTDAIPGLAFRTAGAVGAPCRKNLFAIHTAQSAASARYATDLGFPASFDVRISSDRTLIAGPATNMGAKWTCEKKTTGNTLSTQVSLTDDEFMKFAQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHH5</accession>
    <name>A0A084VHH5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP001997-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHH5"/>
    <dbReference type="STRING" id="74873.A0A084VHH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004551-RA">
        <property type="protein sequence ID" value="ASIC004551-PA"/>
        <property type="gene ID" value="ASIC004551"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004551"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015652"/>
    <dbReference type="OMA" id="LEPEIHM"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000058">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="8">
        <location>
            <begin position="31"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004551-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="399" mass="44093" checksum="2B2E03D9FFD938A6" modified="2014-10-29" version="1">MVRPGLMRGGGRGGMGMGMRGVRGGPFMNKKTFLPRHPFDLTLAEMAFPRVQPVPDDTVLTNALLKRSQDLTPTAQEQTAISNLVAKVQGVLDNIVIAPGDFTKCQLEEVRQVGSYKKGTMMAGNNVADIVIILKSFPTKDCGEVLGKKVEEDLKKSMKTEVVPKAEALSLSYSEKGFEISNSLAKVRCLIATLPQNMRKLEADKHLDFKIIQNHLAAIRHIRWFEENAHHSTIKVLIRILKDLARRFDGFKPLNPWICDLLAHSAIMNNPSRQALPVNVAFRRVFQLLASGLFVPGSAGITDPCEVGHYRVHTTMTLVQQDECCMTAQTLVRVLAHGGYKHILGFVENSTVAKEMSVWDGVVVSPMEPAYEKPSEKKDGEDDDMEGVDGDTIDDDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHW5</accession>
    <name>A0A084VHW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011183-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004794</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHW5"/>
    <dbReference type="STRING" id="74873.A0A084VHW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004794-RA">
        <property type="protein sequence ID" value="ASIC004794-PA"/>
        <property type="gene ID" value="ASIC004794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004794"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015777"/>
    <dbReference type="OMA" id="CINTYEL"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783405" evidence="1">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="31003" checksum="0544FEC4FA130EA9" modified="2014-10-29" version="1">MRWQTVALVALLGAAGVLGCDVPLRHYKTLGCNPIGKLSSGCPERYECPSITAHDNEKCYFNGKTYKIGDTLPGDQVAQFCQASCFCAAEKPFAKFICAQIDCPEFFRRFDHEHCMRTYKKGSCCSDGSVCGAERDNLAQCKVENEIYKEGQRFSIDKTCQSCICTADFDANVTDKNPNCYETTCGFELYSGRKVYGGGVPVYYKEERCCPSQWRLPKESDKVIQGSSAVSNDPNLQCKYGKLTLNVGDKLEIQQEDEEYQKTSCTCSVPPLLHCIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJF6</accession>
    <name>A0A084VJF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000321-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJF6"/>
    <dbReference type="STRING" id="74873.A0A084VJF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005375-RA">
        <property type="protein sequence ID" value="ASIC005375-PA"/>
        <property type="gene ID" value="ASIC005375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005375"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010331"/>
    <dbReference type="OMA" id="HTQESRT"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055121">
        <property type="entry name" value="HTH_69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22979">
        <property type="entry name" value="HTH_69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn-helix" evidence="2">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005375-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="671" mass="73371" checksum="D06BAC06057DD460" modified="2014-10-29" version="1">MLSPKAKRAPGAPPPPPPPKPEKPSGRIAQDDDGGGGGVTNNNSVAPNGHGATVPSRIPDEEQVVMTPLGKTNTSTVLLVERKLIEAVGERTHVAGGDHRGIIINKTTEEPSSRQRDPAQLSLEFRVFLVSANTGQHSQESRRIKFWFRPWLTSDDVQAQVAQDFFRELVSPKEFPRDYVGFIKKIMKLLQKGYNEIQAIEIELRILEQTSAPPSRPSRPGHVIICYGNCHKRAPNSNDSGEHKTYPGGGGGGGDVSFEDEQFEVVPLTPEKILELIEQAYPNPITPDDLAKDHGWEEEEVMAIMLVLKERGLIKSMEYNSYTRIHHDDQAIKIVKQMPTIASNKQPTIAIITAQYCEKLAVDAMLENKETFVRYTTVGESNVYTLGNIGAHRIVSTKLPSVGSTREAMTAAGNTTTRLLGTFQKVDHVFIVGVAGGIPHYTDYRRHVRLGDVVIAAAVPDAAIQKPYCYVYSGPGEVKRYYPIDDGLQAIARTLAHNEDGKRPWVRYVQEGLQQLGGGGANGESHHQHDFARPAPNTDKLYMNIGNRNVIEVAHPVATPSQDDPDGNDGTDGAPTTRLHAGPIGSGHELVRSDSARTEYAQAYNLLATDVEMNSVLDSIVGNCRESFILVKGIADYKDGTTSRKWQNYASLAAAAVMKTIVCAMDAPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK16</accession>
    <name>A0A084VK16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005657</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014041">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014042">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524931">
        <property type="protein sequence ID" value="KFB38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK16"/>
    <dbReference type="STRING" id="74873.A0A084VK16"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005657-RA">
        <property type="protein sequence ID" value="ASIC005657-PA"/>
        <property type="gene ID" value="ASIC005657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005657"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005249"/>
    <dbReference type="OrthoDB" id="6431884at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="238" mass="24763" checksum="627F05AB779B35AC" modified="2014-10-29" version="1">MYRRHASKNTTKKLKPTKSAQLTSTPDCQLDATVHHQTHDPNGIQTPLVDSGGGGGGGGLGGSGGIGGGFGGPLGRRGSPTMIGEPPDGDETDPDVIPNQYERRPPKTTLPTPLFRSPSARLIQRNGGEHLLHEDERHCDGSSLASLTGSHTESYATLGRANNSSVTSTLSPLSQQPSTATLPLPSLPSMSVTSVGAVGSLLSSPASQSSGLVTSTLNEYRFRPEVVTTSNRIQESCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK24</accession>
    <name>A0A084VK24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Rapidly hydrolyzes choline released into the synapse.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014075">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524938">
        <property type="protein sequence ID" value="KFB38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK24"/>
    <dbReference type="SMR" id="A0A084VK24"/>
    <dbReference type="STRING" id="74873.A0A084VK24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005670-RA">
        <property type="protein sequence ID" value="ASIC005670-PA"/>
        <property type="gene ID" value="ASIC005670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005670"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006877"/>
    <dbReference type="OMA" id="LYGLNKW"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005670-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="361" mass="41028" checksum="9AECC447846946D6" modified="2014-10-29" version="1">MEVSAIRLAEAVGCPHDTSKLSEAVECLRGKDPHVLVNNEWGTLGICEFPFVPVVDGAFLDETPQRSLASGRFKKTDILTGSNTEEGYYFIIYYLTELLRKEEGVTVSREEFLQAVRELNPYVNGAARQAIVFEYTDWTEPDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMHGDEINYVFGEPLNPTLGYTDDEKDFSRKIMRYWSNFAKTGYVPKEKEICGESRSDDVFQTPNSNPNPSQLSTDYPEWPKHTAHGRHYLELGLNTSFVGRGPRLRQCAFWKKYLPQLVAATSNLQVAPPPSAPCESSAFFYRPDLIVLIVSLLSAAAFTYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKT6</accession>
    <name>A0A084VKT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">DEF1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00005962</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524955">
        <property type="protein sequence ID" value="KFB38580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKT6"/>
    <dbReference type="STRING" id="74873.A0A084VKT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005962-RA">
        <property type="protein sequence ID" value="ASIC005962-PA"/>
        <property type="gene ID" value="ASIC005962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005962"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022755"/>
    <dbReference type="OMA" id="CATIICA"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.10:FF:000005">
        <property type="entry name" value="Defensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0211">Defensin</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759854" evidence="10">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="11">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB38580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005962-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11742" checksum="9036E537E8D66711" modified="2014-10-29" version="1">MKCTSIVLTVAVVLAVTLNDNASAEAPVEHQHQPDGSLPLESNAALNTLFDELPEETHHAAVENYRAKRATCDLASGFGVGSSLCAAHCIAKRYRGGYCNRKRVCVCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLP8</accession>
    <name>A0A084VLP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP000225-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014539">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014541">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLP8"/>
    <dbReference type="STRING" id="74873.A0A084VLP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006208-RA">
        <property type="protein sequence ID" value="ASIC006208-PA"/>
        <property type="gene ID" value="ASIC006208"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006208"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010732"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011812"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013134"/>
    <dbReference type="OMA" id="AADCESY"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048749">
        <property type="term" value="P:compound eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070983">
        <property type="term" value="P:dendrite guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008347">
        <property type="term" value="P:glial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000289">
        <property type="term" value="P:regulation of photoreceptor cell axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03579">
        <property type="entry name" value="NTR_netrin-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000081">
        <property type="entry name" value="Netrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000048">
        <property type="entry name" value="Netrin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000098">
        <property type="entry name" value="Netrin-A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783792" evidence="10">
        <location>
            <begin position="27"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="13">
        <location>
            <begin position="52"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="355"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="475"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="578"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB38892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006208-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="745" mass="82159" checksum="02C0D64E922C475D" modified="2014-10-29" version="1">MCGVGVSVASLLVGLLSVLSVTPVSPGALDGTLDGGVFSKHASYDPCYDEDRPRRCLPDFVNAAFGMPIVASSTCGQRGPERLCDIASGQSRPRCLQCDMGSARKRYPPVALTDVNNSNNVTCWRSEPLRSATSINDPPDNVTLTLSLGKKYELTYVSLTFCPGATKPDSIAIYKSADFGKSWQPFQFYSSQCRRVYGRPNRATITRANEQEARCTDAHRHGGVEPGGSGVSRIAFSTLEGRPSAPDFDSSPVLQDWVTATDVRVVFHRHQMPPDDSSEESWFRQNGSPQVPPSFRRQPRDLLLPETPSSFAEGSSTTSDYLLQQPSTAGQLRAGSLSRLFHHYAVSDFAVGGRCKCNGHASRCLPTGKEGELSCDCKHNTAGRDCERCKPFHFDRPWGRANARDSNECKVCNCNGHARRCRFNMELYKMSGRISGGVCLSCRHATTGRHCHYCREGFYRDATKPISHRKVCKACDCHPIGSSGKTCNHTTGQCPCKDGVAGLTCNRCARGYQQSRSHIAPCIKIPRVISMVHPQNTAPEGHQPHHQHHYHKPAGGGGSSSQHDPDATSYRTDAGRECGKCRIGTKRLNLNKFCKRDYVIMAKVIGRDIKSDNGNLKSSPGSASRYQQAPAPHQHQRYRDRATEDAAVVRFRLSVQKAFKRSRNPASPLASATKWASVPFIVSARDLECRCPKIKVNRSYLILGRDAEGPPGALGVGPRSIVIEWRDEWHRRLRKFQRQASRTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLS0</accession>
    <name>A0A084VLS0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006234</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01014548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLS0"/>
    <dbReference type="STRING" id="74873.A0A084VLS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006234-RA">
        <property type="protein sequence ID" value="ASIC006234-PA"/>
        <property type="gene ID" value="ASIC006234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006234"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006714"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="227" mass="24843" checksum="F1CF7414535CB2C0" modified="2014-10-29" version="1">MAWRSKGLNNADLIRQLQEFNIIKTESVAQAMIATDRKHYVPENLSPYVDSPQRIGFGATISAPHMHAYALELLLSHLKPDSKVLDVGSGSGYLTACFARFIHQNPAATGYVVGIEHHPRLVELGRKNIGNDDQSLIDTGKVILVEGDGRQGYKEHAPYDCIHVGAAAPEMPQELINQLKLGGRLLVPVGPDGGTQYLQQIDKGLDGKVTHTKLMGVMYVPLTDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMF6</accession>
    <name>A0A084VMF6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein inscuteable homologue C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMF6"/>
    <dbReference type="STRING" id="74873.A0A084VMF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006484-RA">
        <property type="protein sequence ID" value="ASIC006484-PA"/>
        <property type="gene ID" value="ASIC006484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006484"/>
    <dbReference type="OMA" id="CEPEVMC"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="574"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="979" mass="108319" checksum="3099F7AE2E22BA44" modified="2014-10-29" version="1">MSRSNFQRSQSKVWFGNEPDGGGGGSFGGIIGGAFAGFRPYGAATGSYQYHHGFGGAPLLASRMGYPSFHDLEEEDELIEEEQQQEEKQKKQQPARNNDWAEANRQGSPASHKSQDSGFSDTETSPNAVGGHSKGNVSSSLSINDSQNATGEKLTPKRSVDEELLFQRSPSLNSGAPTPPTVIRRPLAKQESVNPSQQTTNGRRLSFSEPTSLTSSIDSEAAKGESSHRDGEGSVRSGGSTSLKRGRVITKNSRVKRNLNEQLSHSSEEMISLDGSELSEMLNQTNCSPGEQLSLHGSYVSVPGTPKGILKPKEEASQSDANNNLHQDEAFKREGRELPTYAQLYPAGTSTPIKHQSKLYRSLPLSPSHRTASPRELQHVKPASSPSGSTTTVVENFYDEPDHLRDSTTASEHAFSYTIYDNPLLNGHTPAVQSWLDGLRFACQSEVMSILQTKSIAAEAGRTTRMTSAVAVKIIRHLQTKVTTLQGAFERVEKLFAAIKRYQAQQDNDEDDEEDEKEIYQKVAPKQKGNDYFGREQVEKDDRRKFLENAQSLVDMTSDLRAAAANADEFDYRSVEEEVQIVKRYFLITVRLIFKNLVKVIVDTVETAKCDLILRSNLSYVAMLSNLDYNGLASLNDAFIANYTVRALLLVCVESKFSSIRALALRALATVCSTTETIRQLERADGLEVLRDILVVDQKQQTNGTGTNERTEPELRETVSVLTQITAPWHGEDHRLEGLKQHVHSIVEAITEIIERTTCCQTLLLCSACLNNMTRIEPTAVYSLMAQDTVAKLKTAAEQRGPGTSIFLYEQFTSMLYNMSANWKCHHHLASRPLVAFLVALFSQKFYEKLPSRTESEAQRKTIKNVLHVLSRLMSGGSLVASSPATLELLESTLVPVFARIERTLDGASEHYRDISSINRWFNESVTSRHGSSPTVVVPVGEMAKDRPVAPHITRLTVRRDPVNGAVITLDKNRQESYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMN9</accession>
    <name>A0A084VMN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transmembrane emp24 domain-containing protein 7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006577</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006577-RA">
        <property type="protein sequence ID" value="ASIC006577-PA"/>
        <property type="gene ID" value="ASIC006577"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006577"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006577-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6131" checksum="35D035CAC6E69FEB" modified="2014-10-29" version="1">MNILFTTERRLLHNEITGGHGHVWCTLHSEAKGAFNSLRFLAGRQSDSRFCGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNB9</accession>
    <name>A0A084VNB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006956-RA">
        <property type="protein sequence ID" value="ASIC006956-PA"/>
        <property type="gene ID" value="ASIC006956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006956"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="17839" checksum="C1EB698ED013D4C3" modified="2014-10-29" version="1">MSTQGSSDQIRRVRDIPTGVWTESFTATGNPSRKTNPIVGVSADLVHAPFGDDDEESCIHTHTHRHITFLAPVVIDTRAHVFRVDVAASLTYQRWQTVLGIPGRTPLDHPDRDDTIKVNKTPQHNNDDDGDDYGADAPLLPTAKLSLPVCSRPQRVRTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNF9</accession>
    <name>A0A084VNF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007000</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007000-RA">
        <property type="protein sequence ID" value="ASIC007000-PA"/>
        <property type="gene ID" value="ASIC007000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007000"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11495" checksum="5F36599FF90DE53B" modified="2014-10-29" version="1">MLPFSVSLFWWNKLSHPSTFRASPPGAFSGYDEKDTKKEDLGRRFYAPSNVANIVMPDALLERAYVKYAESRDKNRTLHGSLDNGSNRINYPLCHREEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNK8</accession>
    <name>A0A084VNK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008502-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006897</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNK8"/>
    <dbReference type="STRING" id="74873.A0A084VNK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006897-RA">
        <property type="protein sequence ID" value="ASIC006897-PA"/>
        <property type="gene ID" value="ASIC006897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006897"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011982"/>
    <dbReference type="OMA" id="KGPYFLM"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="242" mass="25559" checksum="D79A735A472CA976" modified="2014-10-29" version="1">MECSLKGKTIVVTGAGQGIGNELCRTLDQLGAKVIAVSRSPGPLEALKKDCQKIEIVQVDLSDWSATRSTLGALGKVDGLVNNAAIAIIKPFPELTEADFDSTFNVNVKAAFNVAQVLVPKMEAGASIVNVSSLAGLKAINGHCVYSMSKAAIDGLTQNLALELGPKKIRVNSVNPTVILTRMGRDNWSDPAKADPLKAKIPLGRFGEVHEVVEPIIYLLSDRSSFINGHSLPVEGGFLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP10</accession>
    <name>A0A084VP10_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Alpha-1,4 glucan phosphorylase</fullName>
                <ecNumber evidence="14">2.4.1.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Reticulon-like protein</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00007327</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="14"/>
    <dbReference type="EMBL" id="ATLV01014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP10"/>
    <dbReference type="STRING" id="74873.A0A084VP10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007327-RA">
        <property type="protein sequence ID" value="ASIC007327-PA"/>
        <property type="gene ID" value="ASIC007327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007327"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015520"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020361"/>
    <dbReference type="OMA" id="GIEPCRC"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000149">
        <property type="entry name" value="Glycogen phosphorylase, muscle form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2480:FF:000001">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="16">
        <location>
            <begin position="156"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1150" mass="131282" checksum="04E55FF64CA9A3DD" modified="2014-10-29" version="1">MEKKLEDSLFSGAAEADYKAKDSDVFDECIPLVQSTYSEDQLNDKEEPFSVVEQFTTSQPVKSTNNVVLEDEVESDYMNPYVSIRQEKEKSYIHEESAATALTREPVQPTPEAEEISAAPACNISNVVESVSVPSMPDAAKECIQIEQIFKDYGLVESLIYWRDVKKSGVVFGGGLALLLAMSLFSLISVFSYLSLLLLFGTISFRIYKNVLQAVQKTSEGHPFKEYLDMDLTLSQEKVQQLATVAVAHVNSVLTGLRRLFLVEDLVDSIKFGVLLYWLTYVGAIFNGITCVMIGDYRKVRHEAYSCKMSKPQSDVDKRKQISVRGIAQLEDVNEIKKDFNRHLHYTLVKDRNVATVRDYYFALAHTVKDHLVSRWIRTQQYYYEKDPKRVYYLSLEYYMGRSLQNTMINLGIQTACDEAMYQIGLDIEELEEMEEDAGLGNGGLGRLAACFLDSMATLGMPAYGYGIRYEYGIFAQKIRNGEQVEEPDDWLRYGNPWEKARPEYMIPIHFYGRVIDTPEGKKWVDTQTVFAMPYDNPVPGYGNNVVNTLRLWSAKSPIDFNLKFFNDGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIVRRYKASKFGSRDAVRTSFDDFPNKVAIQLNDTHPSLAIPELMRILLDDEKLSWDKAWDIVVRTCAYTNHTVLPEALERWPVSMLQSILPRHLEIIYHINFLHLQEVEKRFPGDFGRMRSLSLVEEDGEKRINMANLSIVGSHAVNGVAAIHSEIIKKDIFKSFFEMTPEKFQNKTNGITPRRWLLLCNPGLSDLIAEKIGDQWPVHLEQLQQLKKWSKDPTFQRAVARVKQENKLKLAQLLEKDYGVKVNPASMFDIQVKRIHEYKRQLLNCLHIITLYNRIKRDPTANFTPRTIMIGGKAAPGYYIAKQIIKLICAVGNVVNNDPIVGDKLKVIFLENYRVTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGNENIFIFGMTVEEVEDLKCRGYNAYDYYNSNPDIKQCVDQIQGGFFSPGNPHEFQDLANVLLKYDRYYLFADFESYIKTQDRVSAVYQDQPKWLEMSINNIATSGKFSSDRTIAEYAREIWGIEPSWEKLPNPGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP60</accession>
    <name>A0A084VP60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007879-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007448</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014978">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP60"/>
    <dbReference type="STRING" id="74873.A0A084VP60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007448-RA">
        <property type="protein sequence ID" value="ASIC007448-PA"/>
        <property type="gene ID" value="ASIC007448"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007448"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006522"/>
    <dbReference type="OMA" id="PFGVECQ"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF9">
        <property type="entry name" value="MIP25013P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783705" evidence="5">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007448-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="319" mass="35430" checksum="58B24584F93392EB" modified="2014-10-29" version="1">MLCSLLTFFGLYSLACWLYENIRTPVLLVVNGIQELIHGNRRSLSQKYGPWAVITGGSDGIGKGYANFLAGQGMKVALVARNEVKLKKVAEEIRNKHGVETKVVVADFSKGESIFDHLERELISLDIGILVNNVGVINEKPVRLERMEKRLLWDLINVNMGAATLLCRILIPSMKQRKRGLIINISSLASLAATPYLTVYAATKAYMTSFSDGLREELRPFGVECQTVSPGYVRTSMTEYFASAEGEPSELSKRVISVSDMIRYAGFTISKADTTTGHWLHGIQTGILKAFPPSLRLKIFSKLYTQLLAEYSDEKPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPD5</accession>
    <name>A0A084VPD5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007199</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPD5"/>
    <dbReference type="STRING" id="74873.A0A084VPD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007199-RA">
        <property type="protein sequence ID" value="ASIC007199-PA"/>
        <property type="gene ID" value="ASIC007199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007199"/>
    <dbReference type="OMA" id="GLMFFTR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="205" mass="23032" checksum="924C8D411A00269D" modified="2014-10-29" version="1">MADLKRDLDEYLLLQENQKKNFKLEMPKMPTIPTPGLVGKLFGRNQEPEANSWLKDTQDTCCPKLSRIQRIVGFVTCMGLGMFCMIVSTFYIPVLILKARKFALLYTLGSLFFIMSFSFLSGFGAMFRQMFSRERLAMSISYSCCMVATLYFAMVAQSTAFTVLFAVAQIITLLWMILAAIPGGMSGVKFFGSMFRSSVSNTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPX4</accession>
    <name>A0A084VPX4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006407-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007476</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPX4"/>
    <dbReference type="STRING" id="74873.A0A084VPX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007476-RA">
        <property type="protein sequence ID" value="ASIC007476-PA"/>
        <property type="gene ID" value="ASIC007476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007476"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004279"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="17047" checksum="22EC7393840EAD4F" modified="2014-10-29" version="1">MVRPREFVQLPASCCARIHTLRRAGYIIRTHEYWDEEVGRRQLYILPGSLSRISMSYLLGPNFFFLNSFELFILHVYDSGLMAQYIQTQREFVALLERNYVSKGWLTLVDLFPLFLLLVFGWCSSFVAFWLEYVSLRVSRNMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ79</accession>
    <name>A0A084VQ79_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">IstB-like ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007657</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007657-RA">
        <property type="protein sequence ID" value="ASIC007657-PA"/>
        <property type="gene ID" value="ASIC007657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007657"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12066" checksum="35FBB52B52670BA4" modified="2014-10-29" version="1">MVGVDPVCASSGADEAIIRKRNRSNLRLRLGVRLAKLPMSEEPDGHGFEFNPSDANEVCKLWGIPTRSREKLPYGKRKPWTGGEGGGFVNHVATTTEGQISAATTYCPTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQC3</accession>
    <name>A0A084VQC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007707</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007707-RA">
        <property type="protein sequence ID" value="ASIC007707-PA"/>
        <property type="gene ID" value="ASIC007707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007707"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9598" checksum="8FA7D68895AB4A9D" modified="2014-10-29" version="1">MVHARNSNRCRNAFVTPCIGDVPSGDLVRLLVPCDSCHGNEQTPIGWIVKLIRRSDLVLLGDSSPADGSAWSQGSSSSGGGLCKQGTVMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR42</accession>
    <name>A0A084VR42_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007942</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007942-RA">
        <property type="protein sequence ID" value="ASIC007942-PA"/>
        <property type="gene ID" value="ASIC007942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007942"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10152" checksum="EFB99B9FF8686FC9" modified="2014-10-29" version="1">MVRNECTGIETLGYPRIRLGNAVSNGSDDEQSIHRTAFPLALNLAQAKEAQPQLALYSHKPNLNHGVQINIPSSRGTFTLFIVESRPAARAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRB7</accession>
    <name>A0A084VRB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003012-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015595">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRB7"/>
    <dbReference type="STRING" id="74873.A0A084VRB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008003-RA">
        <property type="protein sequence ID" value="ASIC008003-PA"/>
        <property type="gene ID" value="ASIC008003"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008003"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021561"/>
    <dbReference type="OMA" id="FHHICKQ"/>
    <dbReference type="OrthoDB" id="5775605at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008003-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20050" checksum="9067370AD109C13E" modified="2014-10-29" version="1">MAKDSKSTFQIIDDDGCPVDPTIFPAFTQDGNALQSIYEAFRFTESYGVIFQCNVKYCLGPCEPAVCEWGRDSVESWGRKRRSVTASNDTVEEEEDMNISQEILVLDFGDEKNRDFLRSEASTDFGRDKTVTIIEPCPTKTSVLALAVTCALMVLVYLSTLFCYYMKKWMQPHKVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS49</accession>
    <name>A0A084VS49_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosol aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.13.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinylglycine-S-conjugate dipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Leucine aminopeptidase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00008225</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-cysteinylglycine + H2O = L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:28783"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:28784"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-benzyl-L-cysteinylglycine + H2O = S-benzyl-L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145802"/>
            <dbReference type="ChEBI" id="CHEBI:145803"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:62569"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:60444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.13.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60445"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.23" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01015810">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS49"/>
    <dbReference type="STRING" id="74873.A0A084VS49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008225-RA">
        <property type="protein sequence ID" value="ASIC008225-PA"/>
        <property type="gene ID" value="ASIC008225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008225"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024391"/>
    <dbReference type="OMA" id="PLCELMP"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF25">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="16">
        <location>
            <begin position="44"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="15">
        <location>
            <begin position="212"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="547" mass="60254" checksum="C15F48A1352B33BC" modified="2014-10-29" version="1">MSFRALQKFFRPSLKSFHYLSIRNIQHNVKIKEQCSNPASRGLVLGVYADENDRLDIGVLTPTAAKYNEAYTSGRLLELLRLAGPMPKRGEVRILYNLEPTYSAVAVCGLGSECLGYDDVEKMDVSKEAIRIAAARGCQELQNLEASRIYVEDFGHAESAAEGAHMGLWVNQELRSVDQRKFVPQLQLYYEPELPCDSNGWRIGLAKAEAQNLARQLQETPSNLMTPTTFAQNVVQILCNSGVNVEVKVRGWAENQGMASFLTVAKGSCEPPIFLELSYYGANTNERPIVLIGQGNTFDSGGLCLKPLEALTDMRADMTGAACVVATCRAVAALKLPVNIRALIPLCENMIGCNAMKPGDVITVKNGKSIEIVKTSNEGPLTLVDALLYAEHFGPKYIVDVSTMSKAVLESFGKVCSAVFTNSEDLWQRMQNASIHTGDRVWRLPLWDYYTKQICSADHVDVQNIGLGEGANSCKAAAFLREFLPCGPWLHIDALNVMKTKGTDFPYIRRGMAGRPTRTLIEFIAQSVVQSTNCGKGSTTKEVQPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS57</accession>
    <name>A0A084VS57_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001453-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008235</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015820">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS57"/>
    <dbReference type="STRING" id="74873.A0A084VS57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008235-RA">
        <property type="protein sequence ID" value="ASIC008235-PA"/>
        <property type="gene ID" value="ASIC008235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008235"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017957"/>
    <dbReference type="OMA" id="PFISCCF"/>
    <dbReference type="OrthoDB" id="8195041at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="957" mass="108146" checksum="C97F9A3C7B09B9E5" modified="2014-10-29" version="1">MNKRESDKLLRLLTKIAKGYGIDDSEEKATGSRNSTESRKRKKTTEQKEAGGKRSRPVEWVNPLLKPLVQSLTSNPNITHQQFHLHHTVLQVPLQPNVLRNDTLFSHFEIKTPWTVRLPVPLYCTPGPGPTPPDPMVRQVLAKYNYKRELASVHRAYKLIETHRSLPNLDLREVEEDDTVKNSAAVIYAGLLDREPDRYLLLESGYDYHFTGGSMASIVTPKGSRTLATVFAAGGENLEEVNIIQLDHLDSQESNKIEAKKSANCLTEDLDGPVLEITADVAGRCVLIRKRHTIVVLREVPSRRSRQENDEEPSTISSGDTEWRATQRIHSNVPFASVCIMNLSLLVKRTISICTTDYRRHMRLWQIDRKADPVEKCSKKLPRNKSRIEMQTEEIPKEDKWSAVRCVDGRSLIACLNRHQIHLYSIREETDRNDSDEEVESPKVKFVFRGSSDVSQWTIACERASALEVAPSERLIFIATCHKIIVANVESLECDEASSSSSSSSNDESMLRVNVLIVFAHNLRQRPVFMSHVAHSGDDDESDEEGGEHHFLLFGSHLPMSYGVCSFTKSCIKGSASEQPQYYTRHLPLHPSTFHDAYRIAQASGHCLSADEPLKRRFYACQSGMVLLPAKGNGSEQEDGYPHIILQTSGGDLLHQKIVTKRLEQDSSSASDLTQSREEHSNVTEELHRWHEKLLLDYSIKPKPYKATDFRTLKRFRDVFNCTYDPDDLKDFLFHPPAKKRPKRRPKKRMGRESSPTRSISSVSDTSLSASVAGDYAAARPEVSNGRRQRPEPLAWRQTIEELQQYKDVLAPGMLAVWGYGGPDFAMSVGTTTGAQSFTEQIPTKLPPYQNVNEFVGNWVAKTLPVEQLGLDTAEGHINEIQDEIPYDEFGLQPWQEPKTNKVEEEDKLPNQFQRLRELAISQNGMAPLSRAGCEVQTVPKPPTSTRPAKKKYVKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSF1</accession>
    <name>A0A084VSF1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP013241-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00008424</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015933">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSF1"/>
    <dbReference type="STRING" id="74873.A0A084VSF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008424-RA">
        <property type="protein sequence ID" value="ASIC008424-PA"/>
        <property type="gene ID" value="ASIC008424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008424"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017132"/>
    <dbReference type="OMA" id="GMHINAQ"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000035">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF203">
        <property type="entry name" value="CYTOCHROME P450 4D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="933" mass="105644" checksum="1D545169F79326B2" modified="2014-10-29" version="1">MVVPMVAVVAALAVAILLGAFGLFRRFGEMLRHAGKLGGPPAYPLIGNGLLFLNKTPAEFLRTIEWLLKKYGNSFRVWLGTQLVILVQDPKDIEALLGSPKYIDKSTEYDFIRPWLGEGLLTSRGRKWHTHRKVITPTFHFKILEQFVEIFDRQSSTFVKVLQPYAEAGKSFDIFPQVTLCALDVICESAMGTKVDAQLNSTSSYVLAVKEITNLIQLRFYDFLIRYDFFFRLSANSRKQKKVIKALHNYTDSVIRGRRQQLEQRATGGSDAGESVGDQDFGIKKRMAFLDMLLQATVDWRPLTDLEIREEVDTFMFEGHDTTTSAISFLLQSLAKNPDVQQKVFEEVRSIVGDDRSQPITLAMLNDMSYLDLVIKETLRLFPSVPMIGRKMLQTTEIIRSGAVQRGTVGREDEPVPVHSVQCGPTELHRSIVDAMFLTVVAGLAIAVAVYVYLAKFSNSLKYSGKLGGPPAYPLIGNGLLFINNTPADFLPTVGRLLQQYGNCVRIWLGTQLLIVILSSNKYIDKSIEYNFIKPWLGEGLLTSTGRKWFAHRKVITPTFHFKILEQFIEIFDQQSSTFVEVLKPYAESGKSFDIFGPVTLCALDVICETAMGTKVNAQLNSDSKYVQAVKEITALVQVRLFHFLIRYDFFYRFSDNRRKTQEALKVLHGYTDSVIRSRREELNRAAQRGGTEIDENANDLGIKKKVAFLDMLLQSKIDGQPLTDLEIREEVDTFMFEGHDTTTSAISFLLQCLAKNPDVQQKVFDEIRSIVGDDRKQPVTMAMLNDMNYLDLVIKETLRLNPSVPMIGRKMMENSNINGKIFPAGSNIIIMPFFLGRDPKNFPNPEKFDPERFNVERSAEKMNPYQYIPFSAGPRNCIGQKFAVAEIKSLVSKVLRNYEILPALGEHKESYVSELILRPGNGVFVRLQPRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSZ4</accession>
    <name>A0A084VSZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011223-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSZ4"/>
    <dbReference type="STRING" id="74873.A0A084VSZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008544-RA">
        <property type="protein sequence ID" value="ASIC008544-PA"/>
        <property type="gene ID" value="ASIC008544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008544"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005181"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="302" mass="35703" checksum="308B3C388A3BB22B" modified="2014-10-29" version="1">MQEMKVSLKKRVETSELNTCTKLEDLKNQFISKMDCMQLQQNIEKKTYQETTQTELNKLREHKKSLDMLIDSVRNMSSLMEKGKKILETQFIHPVRSCRQVTKLSRKYLIHIEEDSKLFEVLCEQNNFSGGWTVIQHRFDGSVDFYRNWTEYRNGFGNLEGEFWLGLEYVHQITKNRPHELLVEIKDFHGNYGYAKYDGFKLGSESEKYELKLGTYSGTAGDSLSYHKNKKFSTFDRDNDALAGNCAESYHGAWWYHLCHYTHLNGRYQSTTNDRSAMVWNRFKNDLRGMSYSRMMMRDIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTJ5</accession>
    <name>A0A084VTJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004039-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008882</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC008882-PA"/>
        <property type="gene ID" value="ASIC008882"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS013471"/>
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        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CBD_Afadin"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AFADIN"/>
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        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
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            <begin position="734"/>
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            <begin position="1058"/>
            <end position="1143"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="KFB41289.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008882-PA"/>
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    </evidence>
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    </evidence>
    <sequence length="1971" mass="216127" checksum="EA9653E0D9372E4C" modified="2014-10-29" version="1">MSLNEKRMFDRETLRSVIQQWNTVRLDIFALSEPNENLEFHGVMRFYFQDEGQKVATKCIRVASDATVSDVIETLIEKFRPDMRMLSLPNYALYVVHANGEERKLNPDEKPLLVQLNWHNDDREGRFLLKNCAQKTNTLDSITDQPSFKRKLSKREKKEQKKKEKLNKLQSGGGAGGPDSENHVAEKLYTELPETSFTRSISNPEAVMRRRRQQKLEKKLQQFRSRDGGPDTGGTLKIYGESLCRDVPYKTLLLSIRDCAQAVVREMLSKYGMDKVDPLHYCLVQVNSDGSEYILDDDECPLSILMNHPTSRGSIMFHVRRRPADSQPRRRKKKPLGVANGGNNIGGDREGPMLIEITHSGDGGRRVKLGSEPIEVGSANTNALQLFGPSIQARHCLISMHDGVCTVTPLHADGTTFVNGHHIQQPTILHNGSVVMFGRVASYRFVDSPSDGRYNLALSQSQLDSACLYESRSPTSPTSWNEEESRPISPISSVQTGPPAVGGSAVGSSFLDNAPPPTGAEVGQSAQQQQQQHHQQHLFAGAVSQQQQQQQQQHQTHSHMHRHHHPSGLLVTALDGPDAVDEAGGGSSSKMHSTGTTEHGEGDLGAGSGGPNGAGGAGNGGETETKSISSYKSIGSTTERTSTFPKLQPSHAATSIAGEPGGQEPILPAVLEFPEQNQEPFLQSVISELDVNSPNFKLAPVYTLYLCARYRASTHYRPDLQPTERAHKLTVFLYHVANLIQNVVQEQYTDAKILSFWMANSSEFLHFLKSDRHISAFSVQAQEVLAESVQTAFRNLVSIFHVELSQTLNQFLSENIDHDSAAGLVLSVLGSAMALLRRCRVNAALTIQLFSQLFHYINVVCFNKFVTTSHMCTSAWGKALSERLSLLELWAEKQGLELAADCHLAKINQCAQFLQAPKTSVPDVQQLACSCFRLNSLQMAALLSQETIPRNLIDTAVRMAESVADELSRADGREIRLEESPELPLALLLPDDGFSCDVVRGIPAGLVDFLNPFQMAGWCRLASQPTSIGLWTVYMHQFNQGRSPSVMSSKLPQPEVQIIKLHKNANGMGLSIVAAKGAGQERLGIYIKSVVGGGAADIDGRLQAGDQLLEVDGQSLIGITQERAADHLVRTGPIVTLKVAKQGAIYHGLATLLQQPSPVIQREMENEFNCNVYDNDGNHRYHFGRSNESLNFYGSGGGSRQSRRGSLRQPLSSTPMINQPYSNSFLTQNDASYRRMSNPDICHQRRYSLSLSNEDILSNDQLQQIHFDPRYRDCRSSTSLNSIYYNHQQQQYRHRSNSLNSIGRIGAGFVMPPPPPPVLRYDTPPSIYVEDYDTRSNSHSSREMIKIEEAAEPETPVAERRSSTACVFEIRVEAPSTESNLSFVADVNLDDIPFIDEDDGEVEDAPGSRSRGTNTTGVDNQQPVAPPPPPPVTVVPSGTSLPSIMINAASRRGSNASCRKTVSFDIINDHHPYDDSDESEGAEQTGKSNIDFGDGDECTVVGPSASLASRVANRLNNNSHSSEQYSGGIFQQRRYSDIGSPSAAVATSEPLSSTTYSNNSNNNNSNSNNNNYGITDAPEYCNNNDEKQDVGREPQKSINVTAPEPKPKGSVEPRAAIDTIRDYVVRHFSGTANINVNNNYYCSNNTADRRKQQQRSVKLDSEASVPCPRGHPLHRERPCREATQQQQQHFATDSNNERPIISATPDSDDDHCKLLRNIQLLKADGTAADRQHYFHPRQHGQAGGGGEGALATSSGSGGGGSGGTKAEDTSIGNPPAERSRLHAHLGVLKSPTIERKPENHRRPPSSSMANNFHAALHGLNPHVLPDAFMLRKVQRCRPDCSNIENQPVALSFLYGARLSSPSSSSASCPDLGTSPGVRQTTPRQLKKQHNILRLLRQINGKLDGNVDTTAPTAAVVDDDESSSANKSRSIHNLAGGGGVVGAAANSQDQGFYQNLSVYRAQNQSHPNLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTR9</accession>
    <name>A0A084VTR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NAD(FAD)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008943</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525091">
        <property type="protein sequence ID" value="KFB41363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008943-RA">
        <property type="protein sequence ID" value="ASIC008943-PA"/>
        <property type="gene ID" value="ASIC008943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008943"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8793" checksum="5F27ED74A238F829" modified="2014-10-29" version="1">MVWTIVERPACFRRDRPIGDGSKKPTVNDVRNRDTYQAAYLPVCSRQEQDDGNGKTRRKFLRLPETPDLAIQTCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUA1</accession>
    <name>A0A084VUA1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009142</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016711">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUA1"/>
    <dbReference type="STRING" id="74873.A0A084VUA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009142-RA">
        <property type="protein sequence ID" value="ASIC009142-PA"/>
        <property type="gene ID" value="ASIC009142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009142"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007790"/>
    <dbReference type="OMA" id="TITAMSC"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009142-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="163" mass="18476" checksum="DB42A46EB7C541DC" modified="2014-10-29" version="1">MPAKKGGQAGTEDAEQKDNSGYYALGGVAVVILYLAFGYGAQILCNVIGVAYPAYISMKAIETRTKEDDTKWLTYWVTFGVLSVFEHFSFFLVQIIPFYWLLKCIFHIWCMVPIENNGSTIMYNKVIQPYFKKYENVADNFISETTDKLKQTAGEMISKVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUV2</accession>
    <name>A0A084VUV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008570-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017026">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525143">
        <property type="protein sequence ID" value="KFB41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUV2"/>
    <dbReference type="STRING" id="74873.A0A084VUV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009403-RA">
        <property type="protein sequence ID" value="ASIC009403-PA"/>
        <property type="gene ID" value="ASIC009403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009403"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018099"/>
    <dbReference type="OMA" id="NINMMAV"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="327" mass="36377" checksum="98B7DBEB87F07EB1" modified="2014-10-29" version="1">MMIPAMLALWGLALIGVYALTCWLYDNFKSLAQICIALLAPYFAPAEQKSLTERYGKWAVITGSTDGIGKQYAFQLASRGLNVVLVSRSTDKLIAVAREIESKYSVKTKWIAIDFSSGREIYDHLRKELDSVPVGVLVNNVGANVDYPDDLDHIPEDKLWQLININVGAVTMLTRTVLPGMKKRGQGAIVNISSGSELQPLPYMTVYAATKAYIHNFTLAMQHELEPFGITCQLVSPMFVTTKMNNFSTTIMEGGLFIPNAEMYAKFATFTLGKTKQTTGYWSHGIQYGVMKLAPEWLRTVIGGIMNKQFRKEYYDQQKLGAPAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUW4</accession>
    <name>A0A084VUW4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008563-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017050">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525143">
        <property type="protein sequence ID" value="KFB41758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUW4"/>
    <dbReference type="STRING" id="74873.A0A084VUW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009392-RA">
        <property type="protein sequence ID" value="ASIC009392-PA"/>
        <property type="gene ID" value="ASIC009392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009392"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004860"/>
    <dbReference type="OMA" id="SEPTICQ"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009392-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13031" checksum="1EA18DD6AD47DBC8" modified="2014-10-29" version="1">MIRGFGATGSRGSQNSSSDRLSEADDEVDVDVEECSDSEEPKSSDSGRVTHSRATETPNSVSVSDEERLSPEPAQKRPTIVGSCNSDDLRPVQCHLETKELWDKFNELGTEMIITKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV01</accession>
    <name>A0A084VV01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP000136-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009690</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017139">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VV01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009690-RA">
        <property type="protein sequence ID" value="ASIC009690-PA"/>
        <property type="gene ID" value="ASIC009690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009690"/>
    <dbReference type="OMA" id="NATCVRA"/>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000197">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="6">
        <location>
            <begin position="10"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="5">
        <location>
            <begin position="269"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="9">
        <location>
            <begin position="773"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1336" mass="151061" checksum="EF4B1258B02C7BE5" modified="2014-10-29" version="1">MDEHDYRSVIIYHARNRYYHTMQRTVLEAMAKYTSEVSFRFFNGLALVLDGIRIQEGIRELNQLRNDRDLGMAVTLCLMYTHKRCHIVDKEELISLDGKLKEERKRLTAQSAYYSALFLHLSGKTEKAKEYADKALRLKPDHVDVLSLKGWSELLLGNTSNHTLELFNRALEGGGKHLDASLGQVRFHQLNSDFDTAIAVLNRLAVRFAESVIPLVEKMRTHLSNWHWEHTTEIANRILVEEPANLEALTVKIMVLLVKDGNYGAGVSALQYLASSLDKIEPANGELFLRLGQLYAAVCGRHPGILTETFKLVEKAVKVNGSNADYLTELGYQAILQRRYKEAVAYFKSATKVNDSSVYTLCGLTLCQMLEGGISDQVTQQLEFLTEIQDTSANPLLLFMTAKLHAANSARAIELLSAASEAHFKNLKALAYGPEYLRLFNPDFLLQLIRELLAHSPVKGVVSVGSSFAATGMLQQQHPVLLQAANLLESVVKACPGLVEAVYLLALVQRLGGEVAAASATLNRILQELDPAYPDAHLLLAEINIDQKQYQRAAQNLEICLSHSFKVRENPMYHLLYGIILKNQQQHEDALKSFMSALNLSGTNTGATTVVPGGNAKSSALGNVKLNSTDRLTLYLEMIGTHQQLNQSTEALKLLEHVSSEFGGTSEEGRLALAMADFYIQQGNHAKAIELLRKMQPDHQYYIQAKTKMAYIYLNHRKDRLTFAQCFRELVANCPNASSYLILGDAYMSIQEPDDAIDAYREALRQNPRDSLLASKLGRAYVRTHQYRKAITYYQEAIANPENYPLKLDLAELYLKLKQYQNAEQTLADDVNDTRADMDDPTVLQMRTKQLLLLARIREKAGQLSASLQTLKEARDNQLKVQQRLLLDHTSGVATEQNKMLSKICVLMAEQSQAIRDNEQMIHHYKEALKYAQSDTVIMAALARVYMQLNRMDDCQATCAQIVQIDPNNEMALVMMADLSFRRMDFESAAYHFSQLLLNQPNYWTALARLIEVLRRSGTLPDAGGFLQRAEEEASRLDGEAGLSYCKGLYEWYRGNPNSALRLFNYCRRNPEWGQQAIYNMIEICLNPDGELPNEGSIADIGADDLEIKDSRAMALRTAERLLNELRPRPGVLDNEALNHRLLENFLLVASRQKYNVERALQNFTSIASQDEYREHIGVIYGMAATHVILKQGQRAKNQLKRVAKNAWTFEEAEYLEKCWLLLSDLYIQAGKCELATDLLKRVLQHNKSCTKAYELGGIAFEKEQNYRAAAAYYDSAWRYCGKSKPNIGYKLAFNHMKNKRYADAIDICQQVLKLHPDYPSIRKDILEKCRNNLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVA7</accession>
    <name>A0A084VVA7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000915-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009461</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVA7"/>
    <dbReference type="STRING" id="74873.A0A084VVA7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009461-RA">
        <property type="protein sequence ID" value="ASIC009461-PA"/>
        <property type="gene ID" value="ASIC009461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009461"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004072"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009461-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="24177" checksum="B9CED1FE997FFEF4" modified="2014-10-29" version="1">MLPHRNTYTTTNLRIRYQNVIISFPAGKRAVSSEAFLADLDPAEIGTIDVSRRVHHQVVELPLELNKYSYELVQLENHHNNAYITMKSNPRPPRKAYGRLSGDSDDVQALQQLRYDASTSQMPPPPDGGKLIDLTGGATTPPDGLGPYQPTASASTKVDGGKGTGYNEDVNQNHSNYNETDSEFELDSKIAEQRLEEQALSRLHAMALAEEDDYGEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVG4</accession>
    <name>A0A084VVG4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00009526</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01017176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VVG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009526-RA">
        <property type="protein sequence ID" value="ASIC009526-PA"/>
        <property type="gene ID" value="ASIC009526"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009526"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020465"/>
    <dbReference type="OMA" id="CLCGRIC"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06624">
        <property type="entry name" value="STKc_ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000054">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000487">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="682"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="985"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1029"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1446"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1119"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="985"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1368"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1454"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166729" checksum="0EC1DAAF6ACD7DD0" modified="2014-10-29" version="1">MAHMSCWPQLWNKNQGNAVNTHVTVVAPGIKTGGSMSNLSDISGSTAVAAASGHGGHPSRPRMDIAVVIDCEQSAFLSHRKAALEEVRQACGQVGANLQLLQFEVLDFGHLETLATFYNADVVVVDLSVRTQQSTLCYQLGVRESFEMNENIVIYNDTENEATLRMKISCGNYQFVSYRLHESGNVIITSPLKGISEDLAGQHLTVAAPQLAPGQQPAPQGGGMSAPPAPPQHTTAITLLTALRKLFQDVEIQSKAHLREKFLADLRSARDQHAGNVEELQRTLRNMRKRLDDPHVLSKEIVQTYMLSLRDVQDYDAMVQLVDDLQTIPNKQNYINTGHMHYLYAFALNRRNKKGDRDRALSTCTKALEKKENHFPDMLCLYGRIYKDMFVESAHQDRESLKNAIIWYRKSFEVQPNEFAGINLATLLVIDGKDFSDSELQYIGMKLNNLIGKKGSLAQIKDYWNVATFFEISVLAENYAKAIQAAECMFKLRPPKWYLKSTIGNITLIDIARKRTDEAGGGGGGGSIERQIFQFWMEFFFEATAAEPSSTVRFPILILEPQKIYMPSYVSIHMDAEQKSIDITNICQQHAKGNCLKLHDFNFLASQIKSVSLYKRDERCAYLYVHQNSDDFQMFFPSVQCRQTFYDLILQMTADQGSGFIDLSSAETTADELKYEYETDDQGRRIILGKGTYGVVYAARDLTTQVKIAVKEVPERNTHDVQPLHEEIKLHSQLRHRNIVQYWGSKSEDNFFKIFMEQVPGGSLSALLRSKWGPLKDNETTIAFYSRQILEGLKYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPATETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTVVEMATGKPPFIELGCPQAAMFKVGFYKSHPNIPEELSTVAKNFILRCFEVNVDKRATASELLDDPFICEKHKKMRPSFSSTSTISGLPPPVTAVGEFARSVSMPADRLVTKTLTSQQSSASCNTPTISSETENLAETPSLEIEAAEQTPTAFQLNRRSSSGGLLSPEVDLATSTSSKSPLVGDASESDGFYLLKKDSQRRTTLDKVLSHDVAKICEVWLGRIEYDRKEKVVITRAHLETLLVALRKYIAEQRKETLEQAIAQLKEQLDFDSTAIDHLHLALYSFQDAVITVLRSHNIKPHWMFALDNLVKSAVQAGIMILSPELGANLAGQAVNDDEERDCIDGGGGGGQGLGGGGGHLGGVGGAPHQSTIVGGRKGGACYYDAGRCRLPTANSKPSASAAAPSGANRRPTLREQLALLRAENSRLKEYIIESQNSYHRAFRAVLESGAFARSLTDQLSALMERCLNERPPEATNEGAGSRPTKDETDAADQTLPEDRPAYDNEASGDRRLAGWLTAQGIDRLACRQRILREGFRYDDFLYDLERSDLRRLGLKMGEELRIWSALKRHRKLHPLKRTHSNDDDDDDGNDSDSDAPNNGKYYLNHNSCAVEPVQDGTERTTVRLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXA9</accession>
    <name>A0A084VXA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011513-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010314</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525196">
        <property type="protein sequence ID" value="KFB42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXA9"/>
    <dbReference type="STRING" id="74873.A0A084VXA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010314-RA">
        <property type="protein sequence ID" value="ASIC010314-PA"/>
        <property type="gene ID" value="ASIC010314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010314"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017939"/>
    <dbReference type="OMA" id="WGVSASI"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784237" evidence="1">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="444" mass="50833" checksum="C60D2AD8CC0983E4" modified="2014-10-29" version="1">MHPYKATLALILCTLSAIALHRPVDGMLLGPPVRNRISRERGNILKNITGTQEYENHIVTSRLDASEPVRMMYRGIREVYNRLLGPTGMRDEGVSLQARVPPNVPFPCDVRGYRSAKPPTSVHQLRPGDFDVVAALGDSLTSATGANSRVFWELLIDNRGLSWCIGGQGTWRTHLTLPNILKEFNPRLFGYSFADSYNVHLPSQFNVAEIIATTSDMPYNAASLVERMKSDPRVNWHKHWKLLTIMIGGNDFCSDVCYQTNATEWINRDQEKYLMTTLHYLKKTMPRTLVNLVPSPLINLSFSIDKVQAPLTCQFVRPIECSCLYGPKYSANRNLYRSLERRFVKIMERVSHRPEFHSDDFTVVYQPFYRDASIFYRRDGKPDLSVMAIDCVHLSQKGHAVSANGLWNNMLEPTRHKTTVLRELFEDFKCPTPHNPYIQTYYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXX2</accession>
    <name>A0A084VXX2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="9">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00010568</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018209">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXX2"/>
    <dbReference type="STRING" id="74873.A0A084VXX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010568-RA">
        <property type="protein sequence ID" value="ASIC010568-PA"/>
        <property type="gene ID" value="ASIC010568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010568"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013448"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="227"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="642" mass="70450" checksum="91967ABB5B747606" modified="2014-10-29" version="1">MASGIIPTLALRSAKGVEVWKLEQQQQQLEFIPVSGFTPDQSKSCRAIVYSPNGRFLAWANGSTVQLCRVSENWKNIASLPRPKACYLQFSPRSTYLMTWEVYTENPKETPKEKPNMFIYRAETGEEVFSIIQKRHQDWQMHWSSDESIAALLVGGEVLFYDHSPTGPGFKQVVKRFGGLRNGGVSVAPGPSPPHIGVYIPGTKGAPSMCRLFKYPNLEMNQPVASKSFFQADKVDMMWNRKGNGLILMTSTDVDASGVSYYGKQALHYMTPKGDSCAIQLTAEGPIHDVAWSPKSTEFCIVYGFMPARATLFNLKCDVVYDFEPGNRNAIYFNDFGNLVVFGGFGNLPGYIETWDLVRRKKLTSFKAPDTTLLEWSPAGDKFMTATTAPRLRMSNGFKVWHYSGALLGEYNWAGELLEVIWQKFESGTFPEVSISDKKVTGIVSTTPVASKQKYVPPGARNSIVVTSSGQTIDLRPPIPGLPPGYRSATQIKNSKKKEKKSKPAEGAENGTTGQAKDPAETKPQAPKKKAPKAAPKKESTGDGDVANGNAKSSGAAAAANATNDQEDNDSTTAGQPKPKPSLTGDPEKDKKIRAINKKLKDIKLLKEKHERGEKLVATQVTKMNSEEQLMKELSALKVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY13</accession>
    <name>A0A084VY13_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010610</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY13"/>
    <dbReference type="STRING" id="74873.A0A084VY13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010610-RA">
        <property type="protein sequence ID" value="ASIC010610-PA"/>
        <property type="gene ID" value="ASIC010610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010610"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003315"/>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010610-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="475" mass="53183" checksum="10B206C0AB1233B9" modified="2014-10-29" version="1">MLPSEVRMRNFRSPQFRDSISDSEEEDLGVLAEPYVETDPDIVELFDGDIQLVIGNVYEMAHDADTSDSESQGSHYSPGMSESDNDSSDISSRPKKGTSDETEGASTSEEKAPHRAIDDYDEEMEEDEVVKAIIAEIKKPRSKPPDIKTDDYVVDISFHPDEDILAIGTSVGDVLIYKFANEENTLSATHELHTKAIRGVEFTRDGSGLISTGRERSILLSDIETGKLKWFVDDAHEEPVYTMCIIGEHTFATGDDDGTLKLWDVRQKDAVFSLKPVEDFISSILTSQQQQKYLLLTSGDGFLTTINIAQRKLYVQSEPYEEEMNCMATFKRDSKLVVGTSKGNFYTYNWGQFAYHCDAYVGPLACANRMVPVTEQIAVTAGEDGIIRAMHVVPGRVLGIVGQHQMAIETLDISGTGELIATSSHDNDVRFWNIKYFEDFDDIKYNSKPDKRALKHNLPSSQRTNVKDFFADLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYD0</accession>
    <name>A0A084VYD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Enolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010849</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010849-RA">
        <property type="protein sequence ID" value="ASIC010849-PA"/>
        <property type="gene ID" value="ASIC010849"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010849"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010849-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="9975" checksum="3F5000B513AA542A" modified="2014-10-29" version="1">MHPVPLSEVCIVTIKGTIQQLLAREKAHKPAEDAGYVIDRSNCAIGPSVANSDRFPEDAVTIRGSKRNRAQLLAPYTPVALCEAFKISSVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYG2</accession>
    <name>A0A084VYG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008842-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010677</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYG2"/>
    <dbReference type="STRING" id="74873.A0A084VYG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010677-RA">
        <property type="protein sequence ID" value="ASIC010677-PA"/>
        <property type="gene ID" value="ASIC010677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010677"/>
    <dbReference type="OMA" id="LCIRRHV"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF291">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6175" checksum="F3617FC9560BEC5D" modified="2014-10-29" version="1">MWSTCPAGSRAFGHVSGCHINPAVTIGLMVTADVSILKGAFYIVSQCIGAIAGAAVIKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYS2</accession>
    <name>A0A084VYS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Abdominal-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010884</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018425">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525233">
        <property type="protein sequence ID" value="KFB43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYS2"/>
    <dbReference type="STRING" id="74873.A0A084VYS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010884-RA">
        <property type="protein sequence ID" value="ASIC010884-PA"/>
        <property type="gene ID" value="ASIC010884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010884"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020073"/>
    <dbReference type="OrthoDB" id="7743872at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="180" mass="19887" checksum="5AAA989E7BCE5100" modified="2014-10-29" version="1">MIGPIHIPAKRPPAFDPDTRLRHSYPWGYDSAADSAYHAQYPPYALATDIKPMYYPSYPTDANFQPHHYYPKYEADAYIAASTERSRGVTGDPPSLQSSYESYNSSGLRSYPGETYPNPGSSLSVGVSGVGSCTPSNPLEWTGNVTPEDDDQLKVELCDVPTAPMCSHIPHPHLVNYHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZH3</accession>
    <name>A0A084VZH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cell division protein FtsB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018817">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525249">
        <property type="protein sequence ID" value="KFB43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011167-RA">
        <property type="protein sequence ID" value="ASIC011167-PA"/>
        <property type="gene ID" value="ASIC011167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011167"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8837" checksum="5B41308BC096E107" modified="2014-10-29" version="1">MRYTFITFAGSDLGNGGKEGIRNRSRNHLRVTRFGENLIEHQHYKKLPSTGSIRQMAPGGHVNTRRASPANGPPGRFCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W138</accession>
    <name>A0A084W138_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011758</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W138"/>
    <dbReference type="STRING" id="74873.A0A084W138"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011758-RA">
        <property type="protein sequence ID" value="ASIC011758-PA"/>
        <property type="gene ID" value="ASIC011758"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011758"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013890"/>
    <dbReference type="OMA" id="ASWRTEY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011758-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11833" checksum="3BF8ACABE6715526" modified="2014-10-29" version="1">MASSTGVVVPRNFRLLEELEAGQKGVGDGTISWGLENDDDMTLTHWTGMIIGPPRTPYENRMYSLKVECGERYPDEPPTLKFLSKININCINSQNGVDGSSAEQMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W149</accession>
    <name>A0A084W149_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00011770</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01019208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W149"/>
    <dbReference type="STRING" id="74873.A0A084W149"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011770-RA">
        <property type="protein sequence ID" value="ASIC011770-PA"/>
        <property type="gene ID" value="ASIC011770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011770"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013216"/>
    <dbReference type="OMA" id="NRHMISR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="116"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="671" mass="77547" checksum="5DD778C9E636E141" modified="2014-10-29" version="1">MTRNGRRRSRSRSPRGRGGPPASRYEIGKLQSLRPVQWSQVKLEPIVREPYRSKATYRRTEREVSEWRRSKEITTKGRDIPDPIFTFEESGFPAEIIDELRYAGFTSPTPIQAQGWPIALTGRDMVGIAKTGSGKTLSYLIPALIHIDQQPRLRRGDGPIALILAPTRELAQQIKQVADDFGRALKYKNTCLFGGGKKRKQQEDLEYGVEIVIATPGRLIDFLSANQTNLRRCSYLVLDEADRMLDMGFEPQIRTIIEQIRPDRQTLMWSATWPDVVARLVKDYLKDYAQINVGSLKLAANHNILQIIDVCQEYEKESKLSILLREIMAEKECKTIIFIETKKRVDDITRKVKRDGWPARCIHGDKSQNERDTTLNSFRSGRTPILIATDVAARGLDVDDVKFVINFDFPTTSEDYIHRIGRTGRCNNTGTAYTFFTPNNAAKARDLIDVLKEAKQVINPKLVELANMKVKNRGNRHMISRYPRERRASRSRSRSKSRSPIASRGRAARSRSRSPLRRSSIDRRSPARRDTRTRGGSVGRRSGSRDARRTRSPRRSRSDSRRRMLPVTRKASRSPPPSRSPVASRRNGRDRDQRNGRSVSRDRERDRERDRERDREQRDRDRERDRDRDRDRDRDRRRRSRSRSRSRSRSGGRRYGTGSNGNGRASSYDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1I2</accession>
    <name>A0A084W1I2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011909</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1I2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011909-RA">
        <property type="protein sequence ID" value="ASIC011909-PA"/>
        <property type="gene ID" value="ASIC011909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011909"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="8965" checksum="97E3B9592C37D55B" modified="2014-10-29" version="1">MVANLKLPPQLTQATNPYLASMPASTYSPYFQPGHLVPTLLGPVSDPSSVSQLGPVVQQAVVSTQQKIPRSDRLEVSVRGVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1X4</accession>
    <name>A0A084W1X4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP008443-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012110</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1X4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012110-RA">
        <property type="protein sequence ID" value="ASIC012110-PA"/>
        <property type="gene ID" value="ASIC012110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012110"/>
    <dbReference type="OrthoDB" id="6150133at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012110-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="217" mass="24289" checksum="6FE2106B19485717" modified="2014-10-29" version="1">MPAISAMCQNVNTRTGCHGCGARQEVGAGREIERIAFVFPLPFFLDNTHEIQSGNGGLVPLLKRSVCAIVRQRTELTLPGFGRPSGQVFPVLPIIRPSDYKPQQLSCATATHLATLDRLITVSERTTDRPVPQKELWFSSGVNLPRVTAQLEKLMGTNVVRLTDRKYMQELQRRIQEDYNVTLEKRISERELKSTCQRTPDDVSCSYSDANVGTEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W253</accession>
    <name>A0A084W253_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Serpin 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00012166</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525273">
        <property type="protein sequence ID" value="KFB44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W253"/>
    <dbReference type="STRING" id="74873.A0A084W253"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012166-RA">
        <property type="protein sequence ID" value="ASIC012166-PA"/>
        <property type="gene ID" value="ASIC012166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012166"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014719"/>
    <dbReference type="OMA" id="GMRWVEL"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="167"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="534" mass="60185" checksum="FEC66A146074C8B9" modified="2014-10-29" version="1">MSVPEFRVPPFGVNQVCCIASLCGKFCSTGNTSIDRNDLLIMKRAHRTRQFPLVGWILKVAQFWAHAAQSYNARYWDEALELSIFFRTLVVLVVAALLCTFQQPGVYGNPQLRTINSQPYPGFPRQVVGSRFQPETPDYAIQFPSPYYQEREVEGQKPNDGPLRFAFDMLKTYVLPQQTNAAICPILPQTLLASLYDVADNEARLELLSALKATPQILQPIVQKQLLATNRSGVNELDYAMAYFVGADTKIKEDVYRRGLENGVSFQKVDFRRQNEAAGIANRWVSEKTRGLIREIVAPGGLDPATRLMMASVIYFKGRWKYQFTDTKQAPFETAPEGQRTQQVPMMYQYNKLRYGEVDFRDGNGMRWVELPYEGTNGLSMVLMVPKQRHQLDRSLSMLSLSDMSNVMEQLTTPRVANKVHLYVPRFSVFSSSSLVPVMKSLGLRSIFDRSTALVGLSNEELVVRDITQRTFISVDEQGTTATSVASLSFVALSAVTPPPAINFTVDEPFLAMIVDKLHSYPMFVAKVSVPEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2B8</accession>
    <name>A0A084W2B8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005169-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2B8"/>
    <dbReference type="STRING" id="74873.A0A084W2B8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012302-RA">
        <property type="protein sequence ID" value="ASIC012302-PA"/>
        <property type="gene ID" value="ASIC012302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012302"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001417"/>
    <dbReference type="OrthoDB" id="7733414at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9492" checksum="CD733F2DE0DF862A" modified="2014-10-29" version="1">MFLGVGLEEANISSIMYGMLGGALAIHVLAHVVFNVLEYLTVRKGPELDVNKDASFSRWRKTTLMVQMVALYAFTIANVVFVWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W392</accession>
    <name>A0A084W392_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP004116-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00012573</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525281">
        <property type="protein sequence ID" value="KFB44686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W392"/>
    <dbReference type="STRING" id="74873.A0A084W392"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012573-RA">
        <property type="protein sequence ID" value="ASIC012573-PA"/>
        <property type="gene ID" value="ASIC012573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012573"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006461"/>
    <dbReference type="OMA" id="ASWEWID"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012573-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="40198" checksum="48E2140C7CF5BE13" modified="2014-10-29" version="1">MQNVTLRLHGTLVARVTVNFTQTNVTTGNEYVKVIPSSIDFDPIPSNVIDRSERVSLVGLRAGIFDLLAHAFPASDLLDQSQAFVRVTVAKSWKLITLSSTIGWAYFLAWTWSFWPQIWENRTRASVVGLSFDYLALNLVGHTMYAAFNCALFWNGSVQEEYLRRNPRGLIPVLANDVAFSLHAVFATTLIIVQCFFYERGQQKVSYTARALMVVFGLVVFISGVLVATGTYQWLDFFYDLSFIKLAVTLVKYIPQAVLNYRRKSTVGWSIGNVLLDFTGGSFSMLQMLVNGYNYDDWASIFGDGAKFGLGFFSVLFDVLFIVQHYVLYRNSNYIELRGENYPGPGSVTTAPRNGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3E1</accession>
    <name>A0A084W3E1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004402-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019937">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019938">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3E1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012653-RA">
        <property type="protein sequence ID" value="ASIC012653-PA"/>
        <property type="gene ID" value="ASIC012653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012653"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004444"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9862" checksum="F4281B1CCDE004D0" modified="2014-10-29" version="1">MANIVDIAPNLAGPVLAFAQTIHMTASFLQPLVTGFMVTDSQNLTQWLHVFGVSSVVAISTYVIYXXXXXXXXPADDQGEPGLKFDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3I7</accession>
    <name>A0A084W3I7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011198-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012725</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3I7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012725-RA">
        <property type="protein sequence ID" value="ASIC012725-PA"/>
        <property type="gene ID" value="ASIC012725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012725"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011075"/>
    <dbReference type="OMA" id="VQDIQKH"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="231" mass="26856" checksum="76745D15C93C6385" modified="2014-10-29" version="1">MEDVHGSYVPDILEHPLVHFTQRWDWDCGLACILMVLDRRQRQTFLSQFQQICDEGQFGKSTWTIDLCYILKDFNVPHKYLTTTLGANPSHRGNDYYKSYTLDMLRVNNKFRFADQNGVDVKQCSVTYRFLIDHLGTYGNIILLTSASLLYCDLCKLNKLSCEIRSCLSITPSYMGHYIVLCGYNKRLQKFMYRNPACKDKVCYISYQALDKARKANGTDEDIILLYDKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3N9</accession>
    <name>A0A084W3N9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011197-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012744</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3N9"/>
    <dbReference type="STRING" id="74873.A0A084W3N9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012744-RA">
        <property type="protein sequence ID" value="ASIC012744-PA"/>
        <property type="gene ID" value="ASIC012744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012744"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009553"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
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    </dbReference>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_C-term_domain"/>
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    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
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        <property type="entry name" value="FBG"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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    <feature type="chain" id="PRO_5001784224" evidence="2">
        <location>
            <begin position="26"/>
            <end position="360"/>
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            <begin position="150"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="360" mass="41159" checksum="4EA143F6D09D290F" modified="2014-10-29" version="1">MYLTIRLVSLLCGVVLLWQFSISTANSSVNSTTDNSIAGYGFEVMMAKLDYLQYKLYEIELGLKERDEEVKEKLTKLEDSIDGIQWAIHRHDRDAGHNLTSLNAQSRKILAQQTACANHEQMRKEIAQLAPKSNVTSYMQWFTKQTSSNSRVKGPFKSCKEAPANKSGVYSIQLSEEGNTFDAFCEQNSFGGGWLVIQYRYDGSLDFYRNWTEYQKGFGSTDREFWIGLEKIYRLTSSRTHELMVELIDFSGSYKYAHYNKFTIGNESEHYILKTLGTYNGTAGDSLRSHHNMKFTTFDRDNDNDSSQNCGVARHGAWWYYSCTSSNLNGRYSNESDAKSITWGGFSSALAYSRMMIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4A1</accession>
    <name>A0A084W4A1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005677-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012988</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB45045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4A1"/>
    <dbReference type="STRING" id="74873.A0A084W4A1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012988-RA">
        <property type="protein sequence ID" value="ASIC012988-PA"/>
        <property type="gene ID" value="ASIC012988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012988"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013859"/>
    <dbReference type="OMA" id="YIVAIND"/>
    <dbReference type="OrthoDB" id="6613906at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB45045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="379" mass="44052" checksum="317EFD9F59E582FE" modified="2014-10-29" version="1">MTFLHNISNIRNAYQVRIMVRLEFPYLLYNATKVQGVYRFFFAMFCKLHNESILFVSNPRQATNHTVTQILYKKDGFKLVPTGEFTGDCLVVPKHTTQGLLYYLLHPFSWPVWTLYVLFAVACIIASRMRFANNLLLTIIFGNQASPEIYSNFERRLVLFAELALFFLGEAYCARLMSLFIASLGEPELHTVQQFVESDIRFEIVNRYQIERYEELRDRAVNVGLQEHIENVQQGSCAFLMPCNNAQLLLNTVLPEKGIPSKYYILKQHIGWHMEGLSVGRFSPITADHLQQLVGLVQQAGLWNHWKHRYIHELDAIIRKNIVPRHSLTWTELMSLMYLLAVGYGVAFFMFLLEFALKSARSRYQVRTQPMRSVTSVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W516</accession>
    <name>A0A084W516_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013256</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W516"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013256-RA">
        <property type="protein sequence ID" value="ASIC013256-PA"/>
        <property type="gene ID" value="ASIC013256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013256"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8413" checksum="0C4F0BFEE6628BF3" modified="2014-10-29" version="1">MGARKSAIRVWNITADSRYPFSNVQPSRCNQNHARWCRFTSHAVLRRRAKDAPSNLDNPEDSPLSALEATDGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W538</accession>
    <name>A0A084W538_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013281</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W538"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013281-RA">
        <property type="protein sequence ID" value="ASIC013281-PA"/>
        <property type="gene ID" value="ASIC013281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013281"/>
    <dbReference type="OMA" id="ANCAPYQ"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784369" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="13153" checksum="B9FD6CD70C33D34F" modified="2014-10-29" version="1">MKAMVCALALAAVLAVANCAPYESESSVVLGVSLPVAYLIPEDATVVRVARSPQFSGSAANAGAQSFNAGGFPGFGGFSGSAANAASQSFSQGGGHGGFGGLSGSAASAGAQSFSGGAGGFPGFGGFSGSAANAGAQSFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5H4</accession>
    <name>A0A084W5H4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase greatwall</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microtubule-associated serine/threonine-protein kinase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00013406</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01020640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020641">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5H4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013406-RA">
        <property type="protein sequence ID" value="ASIC013406-PA"/>
        <property type="gene ID" value="ASIC013406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013406"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020359"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000550">
        <property type="entry name" value="Serine/threonine-protein kinase greatwall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000484">
        <property type="entry name" value="Serine/threonine-protein kinase greatwall, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="70"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="723" mass="81022" checksum="21B655B5A22D8FEE" modified="2014-10-29" version="1">MAQAESASRKDNFVMHDHQTTPKKKVAIPLGSCGSGNNSTMGNDSIFRTLENFTAPNGTVSPKLPTIKDFSILKPISRGAFGKVFLGYKKSDQKQLYAIKVMKKTEMINKNMVSQVITERNALALSRSPFCVTLYYSLQTLSSVYLVMEYMVGGDLKSLLTMYGFFDEPTARFYAAEICLALQYLHGHGIVHRDIKPDNMLVAASGHVKLTDFGLSRIEMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSHDKRIGADAIASYPTNAPIREQTSDQESDCSFDRERQQNDTKISGVSPFFSAEQNISSFEDVKGRPTEATVVEERFDSSAYYTCNSSEDVKTTSEEGSYESVKNVPIMVVKEETQADEKENVESTNRMNEIRGTTAVKDPFECLLVSKKLHRNYTEDSGVSSRKSDMSNIPCEISAIEKVEQHNNSNQKDEYFSSDFSRSYSMSNITESSHHSPVRNGTRGFKMPEYFRGIKRGRQLMNRVDSLASDVDGSSVASTGLTQEIDVLDICGDVHRSTPKKRKATSPIKGVLKVRSLSXXXXXXXHRNYTEDSGVSSRKSDMSNIPCEISAIEKVEQHNNSNHKDEYFSSDFSRRYADKWNATVKGILQHEQHNGIITSFSSSERYPRVQNARILQGYKKRTPTNEPGRFARVGRGRQFGGKHRPYAGNRRAGYLRRCAPEHAEERKATSPIKGVLKVRSLSDDELQTTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6I6</accession>
    <name>A0A084W6I6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013693</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020805">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6I6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013693-RA">
        <property type="protein sequence ID" value="ASIC013693-PA"/>
        <property type="gene ID" value="ASIC013693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013693"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.70">
        <property type="entry name" value="Designed single chain three-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784351" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="318" mass="36654" checksum="4F9C03DCC3566DE5" modified="2014-10-29" version="1">MNIKSFFVLLLVVLIPNQSLCDSVEANYDIGGFQFELLLTHLADFQTFLEDRYESSLSQITSILEQFESRMEKRIGQLEDKIDAFNHNTEYRYESSDKILQSLHKKVDTLEYHIENNTSRIITRIEQYEAKVDGLESRIGKRVEKLEDERDTFKALMEDQLNGKFDTLESHMGKRFDNSTSQIMARISQTESKVGGVESQVKNRIEQVALKIDALQTLTEDRCKTSSNILGRWEGKVDTSKLYMENRIANSASQIITEVSQNESKVDGFESRTAQRISQSSSQVIDTFDRQIKVSDSNVAKRGWENILEQRETRSTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Q0</accession>
    <name>A0A084W6Q0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013857</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Q0"/>
    <dbReference type="STRING" id="74873.A0A084W6Q0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013857-RA">
        <property type="protein sequence ID" value="ASIC013857-PA"/>
        <property type="gene ID" value="ASIC013857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013857"/>
    <dbReference type="OMA" id="VHKLCEE"/>
    <dbReference type="OrthoDB" id="7739596at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="417" mass="47192" checksum="A564FAA45B539006" modified="2014-10-29" version="1">MVDILARNVLLDVEQAIDLFDQLIKAGPDEVEPSSPRSILSAVVHKLCEEELGHVLEIVRFLRSYHQAGVPSEQRIQVLIVGIEELLRYLESLVPCVPKTGCTLLVYGVVDELFASGPDLLDMEEQLQRMYNLKHSLEYVVRDVASAIAHPLADDDCASLAALFEQVSYELLKRIVDEAYADYMHGLQHICDFVEHLPCIDQQISACQVLYRRMNMDANRLRGGATVLAYRIRKVMKYTDFGRSKHADEMRKLKLKLPEGVYGITWTYVNVAGPRFMAPKAKYERVGELKCKPAGWIETCSKTAKHEFQTDDRGVTFAVKNTHTGLFLTDLEGVGFCYVETTPDRWTVEVIKRGEDVWYKITNPRTGNALVPTGEVHIGVVGDDQCDGFNLVDFNERSLVVVQKFELHRKKQACVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W733</accession>
    <name>A0A084W733_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013998</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W733"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013998-RA">
        <property type="protein sequence ID" value="ASIC013998-PA"/>
        <property type="gene ID" value="ASIC013998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013998"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013998-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5611" checksum="8AA17305501153F8" modified="2014-10-29" version="1">MILPGLALYRSWFFHPAKPFEMKRMNRCVPPVLYWGSFALRSAPGVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W867</accession>
    <name>A0A084W867_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP008143-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014409</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W867"/>
    <dbReference type="STRING" id="74873.A0A084W867"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014409-RA">
        <property type="protein sequence ID" value="ASIC014409-PA"/>
        <property type="gene ID" value="ASIC014409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014409"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023440"/>
    <dbReference type="OMA" id="GLTDHYF"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="798"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="806" mass="89599" checksum="CFFB4161490D8813" modified="2014-10-29" version="1">MDVTVEDFCEETNFADSPCPSPFDAAKLLNVGFLQISGRFTPHSAPPSGCSTRTCSLATTPVPPEEDDCGGADGDGGCGTADGHLTVDGADGGERMRKWSLPNLPTEATKFVLSGRATPVFTWNPVPTASNVIYSMNEKNQQIVFSQLEQEIVTESSVSEVSSVSDSEDLELEEEEEPVEEDPEGDTELEGMKKKAKDATGKTGPEGPEMYPNCDVNVWLRSCEQEIVDPIEGTVQGTVPEWLNGSLLRNGPGSLKVGDMMFNHLFDSSALLHRYEFPLLPMGRGQIALIILFSTNRFNIDNGKITYQCRFLKSDAYKKNNAARRIVVTEFGTSAVPDPCQTIFQKIAAVFNKPGVNNSDNAMISIYPFGDEFFAFTESPIIHRIDPETLDTEAKLNVSDYVGIVNHTSHPHVMSDGTVYNLGCSVTRTGPAYTIICFPHGPGMFENARIVASVPARWKFHPGYMHTFGITENYFVIVEQPLSVSVPTMVVSQLRNRPMAAALKWFESQQTYIYLLDRDTGELRHTYHSDAFFYLHIINQYEQDGHVVLDICCYKDPAMLNCMYVDTMRNMQNNPDYATMFRGRPLRFVLPLNYGDGLKRSGGKRSGSDDPATSWADMWQYLGPDDDGDALDRNRKPPSTTHTTDDGLVLQNLVQLAGTKATAYVMPNRTIFCRPELLCDLGCETPRIYYECHLGRPYRYFYAISSDVDASNPGTLIKVDVVDKSRRTWCEENVYPSEPIFVPAPDPQSEDDGVVLAAMVWGREEQNRVGLLVLDAKTFTELGRCEFTTPGPVPKCLHGWFQSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R6</accession>
    <name>A0A084W9R6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014974</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9R6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014974-RA">
        <property type="protein sequence ID" value="ASIC014974-PA"/>
        <property type="gene ID" value="ASIC014974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014974"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014974-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="236" mass="25220" checksum="FB1EEA03763EDE77" modified="2014-10-29" version="1">MECQGVPKGQQGVVLESMVHYGFVSRLFPAHTGSDEHRNPEPRFKISRWHVKLQQQVQYRSCSRHAIANTGKDKLATESCAFTCAVNACVLSCESTTCFTRRSIPARRGKVEEHTIAQNSGTGTRFHSSNRCVGVDDDGGEMVVSMRPGSNGPQLDAERSTACAARASGFSFVTAVPSGGGFHGTSGPVVIREICAASAVRSNEVLDVSTSVLAVGCCGLGIQCVRELAVLLVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA29</accession>
    <name>A0A084WA29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002331-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00015116</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA29"/>
    <dbReference type="STRING" id="74873.A0A084WA29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015116-RA">
        <property type="protein sequence ID" value="ASIC015116-PA"/>
        <property type="gene ID" value="ASIC015116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015116"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018542"/>
    <dbReference type="OMA" id="ARYLMWI"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="100"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="341" mass="36375" checksum="D044517C9484D736" modified="2014-10-29" version="1">MKTQIHTISVPSDGSYDNEALSCSTLDISTHNGEPHGGLRGSNEFILSDSGQKINSDDQTGQLHLWLQRKAKSAFSEKMIKKRLPILRWLPQYNSTDAIGDLVAGITVGLTVIPQALAYSGIAGLPAAYGLYGSFLGCIVYIVFGSCKDVPMGPTAIASLLTFQTAGGNVGRAILLCFLSGVVELMMGILGLGFLVDFVSGPVSSGFTSAVSLIIVTSQVKDVLGISAKGSTFIEIWRNIFNDIHNVQLWDTFLGITCIAVLLIMRIIAGLKVGPADDELKSKNHRIINKIMWLVGTSRNAILVVVCGAIGYSFQASAAAPFKLIGDIPPGMPTFKAPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAN1</accession>
    <name>A0A084WAN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">tRNA (Uracil-5-)-methyltransferase Gid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015303</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015303-RA">
        <property type="protein sequence ID" value="ASIC015303-PA"/>
        <property type="gene ID" value="ASIC015303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015303"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12020" checksum="2E83BE453E1CB5B5" modified="2014-10-29" version="1">MTNTPMEPVDGGEGKKKWLVFRMERKKQPKATEWNVVGLGNQRRVFIEIPRFACASFSVESSFCRSLFQRGVLGNVCVSVCILYRGLETHLVKHTPGRARDCFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB84</accession>
    <name>A0A084WB84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012173-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WB84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015430-RA">
        <property type="protein sequence ID" value="ASIC015430-PA"/>
        <property type="gene ID" value="ASIC015430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015430"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008587"/>
    <dbReference type="OrthoDB" id="7739966at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015430-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1758" mass="202635" checksum="E08B4E8A5F1F589E" modified="2014-10-29" version="1">MTEQAKKTVEAKCDKDAGKTTTPSPQDGGLKNSLHGVAYQLKLLLMVVLQAGRMMQEDANFTCTISTEDPDEGKFDDIVFRYRFQGTPRILSIQAKHKSSPEQKLSWQDLANSSPNAPFAIAKYFTSFLEQRKRDEEAEQKLVLCTNAVLDECVKRVLKEHNTEMLKETDLCHIFKRIESSCYSFGAAERKKSKELRRIVDLLRESSDCYGLGKLLASTVYNGTRLDLNTRNVQRAPLLVNYRNAIVQHILGEKREKTVHHLREEFCKGTLPSGGSNLRKVFESEYQKLSGGNSDVWDDARAKGITLKEGLKPSKDLQGDDHPGDSSLPENLVTDEIINEFFDRFLLVCGSRSEDQLSQTVMDFWKQTNTEEHPLKDTDDGDKTAAYNEMLKVVFDWMKEQKQPPTPLTKVDIEKLFERIAFGIKYPELRCVGRIFEESLELDKYFIKIQPESVAQLPLFNFLCQPYEEAVFRVRSPYAKTNVSMVVQQFLQSFQALQKNEGRYEVLFLDSAIFKKIKKSIKAVLRLKNFRIILVILCNGGHPELLDKLAKYNQSHPGICCSKKIILIEESSSKDEDLLLVSDLSAESKEELLQGSNACLKLFGTETLLRHLIDESDDLACLLEVLDSLTQLTAEPILLEERYDTIRDWYIQRNVRPYQSRLSSMWAVRRSLDSTHFREGERMEFGTFFNALKRALGIKLFDDWHIKHIIDWHEQGEAIHPPGLLEDSDDEAKVHIVLDEAGFGKSTYLTWLGWYLRKERTSWWIVRFNAIEYSTDFEQILKSGYEGMDDTQALRLLFQLVHLALFVRDINRRSIEESDRERAKAEQCASLMRLEAGQLVLDETKAKCIHLTTIQRIELRLFREKFNGKQLVILFDGFDEIVPYYKEIVYRLFTCWQAFEGIHKIYLTSRPYELKGEFDRVFGERVQFHQLLPFNKESRLISIHIFLRSHVPLYGVCEESARNDLLGSLEAIVRCYLFELRNTPLFIRMGLEIILPLVQEYVDFTEGTISGRILDAINTSLEKLRMVETFIEQKLLIASVEKPQMTEAAKKTAYALDNAADLNRWAHRMHSTLALFAMFGTSERKRLLSETDELEALEYMEKVRQGSVKSGLIEGIIGQVPLFIHRVFVEYFAADWIYRHKRGMLSETLTVVGPRWFGGSRCEVAEFFDRMLIRDGGSKPIHLATINRSLADIRSLLKADRQRALETDAGGRTFLHLLTLYTDEGQFKRTPGQFFDVLQLLDTVCVDSRDRLRGWSALDYSLMLHYTTLTRYLIKRGATVNTDTLFQQIVTNGSNVEEVLHQAASYEHQLWNFRFSEGSRRYLSEVPRKIAEYLVHEQHLDMQENLPNAWGCHRTALGYCVEKDAAGMFRSLVKLAGGHRKVPVDRLLRKAFLDQAVNVIQYLMVECSCSPPVNLLGMGLFPVLTRAIECHYMELFAILLRRFCVLKRNPVKQFLSQLLSPVDDKQPDEYYETQNFGPWSFEDILPINSYFVRLLCTAVVSGSRYAVRHILRFTRTSVSSRLIMIIMTAVADQQIHTRCLDPLGFLISKCQDLHAPDHDGRTLLQVAITTGWTSVGRYLMERKGFDSQHALHWCVSQDSFRLHPWVLPARLKLFRYLMRKYPGREAHHIRDRNGTAVLYLAVLNRHFGMAKLMVEAALGSVEGQEQRSVAFCNILKDANLADKQISHGFLEWLIQECEQDDKEDDDLLWKAVYQATFKWIESEQTLEAINPASCNTSEFPGMWLPVEEKPMDIYSTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCP8</accession>
    <name>A0A084WCP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP005219-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00016103</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022807">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022808">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022810">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022811">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WCP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016103-RA">
        <property type="protein sequence ID" value="ASIC016103-PA"/>
        <property type="gene ID" value="ASIC016103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016103"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009339"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009892"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014592"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022675"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023394"/>
    <dbReference type="OMA" id="ELIITWQ"/>
    <dbReference type="OrthoDB" id="6429135at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1666"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="354"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="435"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="535"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="630"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="724"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="813"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="915"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1445"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1540"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1819"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1914"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1819"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016103-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1988" mass="220206" checksum="CBC9B4D55772ACA9" modified="2014-10-29" version="1">MEVVKTSLSRLPALVQYLTLAILIKETLASENLQMPNFLHELPSTILFSNDTGNAQLVCQAYGGPQMIIQWILKDGTLVNSVPGLRQALPNGTLYFPPFAGHLFRTDVHDTTYRCRISYSYYVLLSHDIRVRAVVRQPYEVKVESADVTLGNTAFLKCFISPHVREFVHVSSWFSEKEMLLPGRSDIGTRYVVTTPGGELCIRNVNEEDRLKRFSCVTADRLTGERKTSEAVLLTLKDNTPNMAPTTNQKSLSELSVGKGTSVQLPCNVQGNPVPSFSWFRISDTGSLYTVPSSQRIVPSQSLLFIRSVDERDAGRWICKAFNQFGEQKLEIHLTISSELVAHIQPQIQIINSGSSALLNCSIFGSEVHKIEWFHNGQELFANGRTERSMSLLAANTLQIDRVSKKDQGIYQCIVSNARSSAQGSSELKLGESPPEISYGFVVQNVRASAYVSLKCSAAGSPPPTFVWLLDYQPILDVSSLHRYTMDQFLDINSHVTTHLNISHVHSDDGGLYTCRASNSMGSASHKARLNVYGPPYVRAIGPITAVAGEPIEMHCPYSGHPIQSVRWIRGGNELVSGPRYSVADVQRGGFLKIHTIDPAQDRGPYTCIVTGANGDEGRRELQLVVHSPPVIEPFSFPKTMKVGGRAQLTCSVSAGDMPIYFSWKKDGAPIAQDLHVSEKKEEFFSLLVLKDITARHSGRYTCFATNTAAQTNYTAELLVQVPPSWTHEPHDIAVVLGHPIVLPCEADGFPQPRITWFRGKGKLSTDFHSIASKNNSLSINYATSPDAGYYMCEASNGIGNSLKKIIHIDVNEAVHFDTPVKNVSARRNDAVMLECLALGDEPINIIWTHKHQRIDFNNYRYNIIEMKEAVGVRSQLSISLTERYDSGKYVCTAENLYGTSEHVIYLAVQERPDAPSDLEVMEVSSRQIRLSWKRPYDGMSPVLSYLVQYQPVRMGREVLAPDSPVGPSTVAVWDSALTVNVTFSKVNMIKSIDGGVRDETTVGGLLPATQYLLRMLAINEIECSSFTNPLVVRTQEEAPSEAPGGLKVKAGAMGELVLTWQIPNRASWNGELLGYTVGCVEERTNINFIASPSVSVANTTHTVHGWATTKTSVGGLKKFTRYALRIRTYNSIAPGPWSPVVYGTTSEDAPEAAPQNVSCASLSSQSVKVLWQEPPPQFHNGVLQGYKILYRPLTKNNEFVYPFEIKRTSNLETYLHALLKATNYSIQVLSFTLSGDGVASVPIYCATEEDVPEAPGGIKALTLTADSILVSWLPPAHPNGVITHYTVYGKDHGKKGSAKHNIVRVDERGRPSMHEVRGLSENNKYDFWVTASTAKGEGDPTPVVSQTTSTRAPAKIASFSRLLKVPVGVELVLECVAVGNPTPRTRWLTKEQAVTFSQYYVISQGFLKIHSVEPPIAGNFTCSAKNLFGEDEIHYTLVALQTPNVTQLSVQYTSFDSLRVTWEVASDGGAPIQGYGLYFRTTGGPWTSVPIPSDQVAYTLNGLKCGTQYLLKINAHNKVGVGPFTEELAVRTKGKAPHIPEERELFSTNATCLSLFLTSWLNGGCPISHFSIEYRRLHTPFWTIVSSDLSGTDQHTNGSISFCDFVPATWYELKITSNNDAGKTMAQYNFATLTQSGEKIPPPEYKAMPEEDRDTDLLQQEDFQWLQSTVMVVTLIVVVLCLVVVAKYRGILCFTNHSDRYSTQTLSADLSLKEQSENVRNQQVYSASPVKVINKEENAEMYEISPYATFNASTGRLCKEPRNLNPSNIDYSLQFRTFGHPECDLNATAYPLLEATGHMPGHIKGKSSWHKQQFYNTDETPLNMPNTTKAMGGKWDDGALRRMGQRSFGPSNYSESDSSSPINEFSNAPTFRIPSKTPCPTSILHHESSTESIKELSPVRDHHRANTPRHVQATAAKGHFGHPLRTKDNHCLDMQPSSSTHRYHNKTYVTAAEFSETESDRERALDLEVQRAMEKAIRQDECKSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDN2</accession>
    <name>A0A084WDN2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sensory neuron membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016308</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDN2"/>
    <dbReference type="STRING" id="74873.A0A084WDN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016308-RA">
        <property type="protein sequence ID" value="ASIC016308-PA"/>
        <property type="gene ID" value="ASIC016308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016308"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009342"/>
    <dbReference type="OMA" id="QYRQKDN"/>
    <dbReference type="OrthoDB" id="195015at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF109">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB48326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="541" mass="61444" checksum="5317BEF1D6DEFACF" modified="2014-10-29" version="1">MRTHQLRQGTDQYKRWEALPQPLDFKVYIFNVTNPYEVMQGRRPKVVEVGPYVYFQYRQKDNIRFSRDRSKVYYSQQQMYVFDPESSYPLTENDELTVLNMHMNSILQIIDNQAKETITNFRSDVNNTLEKIPVVRVIKRIIERTTPIQSILQIAEDETYDSLRLINAELNRIFGRPDTMFLRTTPKQFLFEGVPFCVNVIGIAKAICKEIEKRNTKTIRTMPDGSLRFSFFSHKNMTDDGMFTINTGIKDPARTQMIELWNGRTTLDVWNNRSSGLPSSCNKILGTDGSGYPPFRTGVERMTIFSTDICRTVDIKLTGSSSYEGIPALRYEIDGNFLHDIGPEYGNECYCVNKIPKSIVKSNGCLYRGALDLSNCFDAPVVLTLPHMLGVAEEYTALIDGMDPDPDRHQIFVDVEPYTGTPLNGGKRVQFNMFLRRIDAIKLTDRLQPTLFPVIWIDEGIALNEDMVKLIDDSLMKVLSLLDIVQWVMIGVGLLLAVLMPIVYFVKRCGGDGSRTVSPAVTATTSAASLSMAGVTGERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDR5</accession>
    <name>A0A084WDR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016479</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDR5"/>
    <dbReference type="STRING" id="74873.A0A084WDR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016479-RA">
        <property type="protein sequence ID" value="ASIC016479-PA"/>
        <property type="gene ID" value="ASIC016479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016479"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003426"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005669"/>
    <dbReference type="OMA" id="CCVGFPI"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF197">
        <property type="entry name" value="FI04477P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="189"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="376" mass="42083" checksum="7A3074C196360506" modified="2014-10-29" version="1">MSHDANEAPSEATPLQRETQQYQTVLHRDSSHNNAIPPSSSVSSSNTSASSVLPPSGAASSEREPIVSTTNGRKTARTNTKMDDTKKVLLKVGFDFLILCCVGFPILIFFVAGDPFKRGFFCDDESLMHPFHDSTVTNWMLYIIGLALPIIVILLTEVIRGRRKTSEAHPLKVWNYDIPFWVVQAYKSIGMFGFGAAVSQLLTDVGKYTIGRLRPHFFDVCQPKMRDGTFCNDTINQGKYITDFECTSLKSSTRMLKEMRLSFPSGHSSFSMYTLVFCAIFLQARMNWRGSKLLKHFLQFLLILLAWYTCLSRISDYKHHWSDVLSGAVLGATVAIVVSNFCTDLFSMARKRAQGPIASSLPQTRYELSTNHANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE47</accession>
    <name>A0A084WE47_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00016864</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01023139">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE47"/>
    <dbReference type="STRING" id="74873.A0A084WE47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016864-RA">
        <property type="protein sequence ID" value="ASIC016864-PA"/>
        <property type="gene ID" value="ASIC016864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016864"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018449"/>
    <dbReference type="OMA" id="PGMGAPF"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="518"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB48491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="699" mass="75679" checksum="1F89C0659EE0C1EE" modified="2014-10-29" version="1">MRTLGLSVISMLLTGLVIGNAYYQKKQFYPSVVYITKSNPSMAVIYIQSLVLVLMLGKLMKKIFLGTLRAAEFEHLMERFWYALTETCLAFTVFRDDFNPKFVALFTVLLFLKSFHWLAEDRVDYMERSPVIGWLFHVRVAGLLLCLGLFDYELISYAYQSTISKGVTVQLVFGFEYAILMTMVINTAIKYIFHAAELRSDTPWENKAVFLLYTELIIGFTRVVLYVVFVILMVKIFTLPMFAFRPMYYTMRNFKKALNDVILSRRAIRNMNTLYPDATPEELQMSDNICIICREDMVSNSKKLPCGHIFHTACLRSWFQRQQTCPTCRLNILRTPITAATTAANPAPNNNANDGSTGAAGAGTDASRPTTGVTGAGGVAGANATGSPLPNGMAPSATNALPLFPGAPLMLPPFPFVGMPPYTMPLPPVPPSLDTLTDEEIRAMEGTERRHIEERIKHLRNIRTLLDASVALMNQYAAITARLPPEAVAHLQAPPPSLPGQPSTVIPATATVPLTAVPVVPGEPSPSTSAATVNTGTAVVDPTPATMDVADGTTTPGSSKGASSEGSSKSSNLISDSNSSIVTNANTGKATSLAKLEDLGPISSDEDDSSVKLKKEPLPSTSKAFLITPDQLLDGDSSIEGAISSSSITTTATTRPQTTVNGTGGPSVNRPESSAMSELRRRRLEKFATQPSSAGSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFR1</accession>
    <name>A0A084WFR1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00017068</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFR1"/>
    <dbReference type="STRING" id="74873.A0A084WFR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017068-RA">
        <property type="protein sequence ID" value="ASIC017068-PA"/>
        <property type="gene ID" value="ASIC017068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017068"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005350"/>
    <dbReference type="OMA" id="ANFCANG"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="696"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="837"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1112" mass="119647" checksum="769CEEF77C8F3954" modified="2014-10-29" version="1">MASGSESSDEFYDAMDDSLVAKTLDETTISNSSSKRRSGRPHDTEFTPAFSALHLEQPNHSRHGQPAEESGAHVSSKEPSKSPKLGAATGFATSVAEHVFKEPKSLRSQRFHEFRQAMQNDEDENPGNILTPDSQNSSVEGVYVAPRSNYPFRVIESDVTSIHSICSLGIVGRIMAGGSIDASDSSTKEPTVSAKTNEMLSAVISTVSMPLAEPRPVAPPRRKKKMRKLSSSSSDQCTANETGGGGGAGTSDQQPTDSSSSEVLMVKSAQSQPMIAKLSTDDLGSGSGEAMAGGTNGGSIVSSGSDGTTTTGGADSYSGKTLPSPATLESITREIENSFEEAASAVNGGTGSLTRLASTSAAAVTSGGVGGSAGLSRCTTTQLSPTGSMKSVSAMARASWTDNSQGLISRVTKGQYVVKPTDGVFNKAEGPSGDEIARIGRIHKEFLSNISNSGSIGGTGAPGGGGGGGGPGRGSLGSHRKNYSITGTNSLEGGMRTSLMAKQLHVKERRKSAGDEDMLKQLNMYVRTRTSSGKQLTDMEILEQVPVKNLDTGENFPLSAVEEKLPQCINPLSLHIMRLTSHIPETDEESVGPGQPGDSDSVQPGYEEELEAEGLEGGRLKRRTAAKLKRFFRTTAKKTVSKAKSIASEVSHARHKEDVADIQDVSNPEQNIKIKASSTNKGPYDFAKLQHVQDLTGVHTVAVWCMKFSSCGRLLATAGQDRVLCIWVLKDAYPFFQALRTKYNAADQKSSPTPSEESLNSTLNAAHGVAAEDGAALPEPPDDVSPGPFMPHSFCTYSGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPEKKVALWNEVDGQTKLITAANFCANGKFAVVGSYDGRCIFYNTDQLKYHTQIHVRSTRGRNAIGRKISGIEPMPGEDKILVTSNDSRIRLYDLRDLNLSCKYKGYFNSSSQIKASFSHDGKYIISGSENQCIYIWKTHHEYTKLSSVRRDRSDFWEGIKAHNATVTCAIFAPHPEAIIKPDPDESTSADNISVNQSFAEQSKKACRGYVMVSADFNGCIKVFINKTKPKHSSLPYTAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG60</accession>
    <name>A0A084WG60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Sulfonylurea receptor/ abc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00017206</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WG60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017206-RA">
        <property type="protein sequence ID" value="ASIC017206-PA"/>
        <property type="gene ID" value="ASIC017206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017206"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001721"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010042"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012240"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012420"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013625"/>
    <dbReference type="OMA" id="FFWIGHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000161">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002459">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1613"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1691"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1802"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1827"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="664"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1566"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1910"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1424"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1486"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB49204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2158" mass="237732" checksum="C8E52F493034D4CF" modified="2014-10-29" version="1">MVAEWGNDGGGNPFPTVIGPAERLQPPPAAVRTLYHLNLWSLLVDALVLAGSLLTLGYAVWKHGKRRHNLLALHNLRSIVLLAALVVALGEIGHQWLAVGRLEPVRTGSTTDPDRPDPEAHSAQSEAFGTTMTTTSDRPIGGGGAVDADADAVGWKMATFGFGAAWFGLLAPVGLAMLIRAIERRDKCGLLYIALASEGAQSIVRWCKFKYINDVTDTATGPTAGSSIVGSPEVFLTLAGALTATTLATVDGFTLYLEQNSGRRHVSSIMSGEKRLGYKTPHSPFLSKITFHWIVPLLWRGYREPLELESLGSLHEKDTSRYHYDQFLFIYQSYKSVRASLWRCYVRNGWRMFLVGGFLKLTGDLCALVGPLCISNIVDYIAATQGRFSAVASLILANDTASREGRQPTTLGDGLGKSNQSPGTQTVGLESDLGPITWSTLLANGWVVAVLVLVASLAQGTLSQASTHLMDAEGIRLKNALQGLVYRKTLLLSSSCFHSVQERRGALVEGGKPQQSNKPRTKSLDEGEEQAGKESRRTVNNRAATVADAERIQTDAEVMHHKTLPSDKMAAQAEEVGRGSVSGRRDAAIDVNRVQQFADGSEAHTSATHKTSPESEAEENSVRDVPESATPASEQRPGNAPSRDTTEPPGGTSMGGPEPARSFAHDAGTITNLMSDDAFNVMSFVKMVHYVWAIPLKIAVVMYLLYRQLGISTVIGSVVCIVTMTPLQILIGKLMAANSKKASECTDERLRRINEVLLGIKLIKLNAWEGVFKDKISQARQQELRHLDLDSIYWTLMMLLTHISSVLITIVTIAVFLALENNPIELTAGRLFASLALFNQLTVPLFIFPITIPVTLSAVVSTGRLEAFLAQPEVERGSLEGIRTMAPDREPADTAPLSGEGRCTASQQSSVSSGRSEKCTQPERDRAGGGRPKKYQKSTGPNPRVKLKKNSQLSVSARLEKCRQKQKHLAREMRFGLPDDVAVLLKDARFRWVGGGGRKAEPTAETADPAIYTLYVEQLTIPKAKLTVIVGRSGSGKSSLLAALLKEINHLSGELLWNKYSSIAYVPQKPWLQNATIRENVLFGESFRPKRYDRVLRACALKPDLDLMPAGDGTEIGERGLKLSGGQRQRIAIARALYSSANVVILDDPLSALDNEVATYVFEHGIDRMLSRQKRTIILVTQRVQLVHRADNIVAMERGAVSATGSLTEIENNYPHILREWNAIIAKEQQQQSSEAQSSPGRTARERWKLFKNISRIGFQRSHAVEENDFMEVSNRKSNSFIPRRFLLHQRTFYLSRTLANRGTLFGSRFAAHDFPLPIEDCHEPNVALRRHFSSRLRKDSPAATALAIQREPLAVIGNAVAHGHQSVFRTLSLQTGVGTGSGSTQEATGTEPNTVQRQPAVVVRHVSFPTALTAFGAVRPFRPSNAGNDGNQFRAGDQGISSNDELKRSSIGFRIPEFFRRMSFRGRRFSNPTEFGRPYGERNATRGSSSRKTSSLKSIPKERHRSIRRLLSTISRHSQDTEESSVDCEGEVSNRLLYDDERKYGRIPTRLYWLYLKSCGPKMVAVFFLSALAQQALKVYTDFWLQEWTDQTSATVATTRLVRAPANIEHHFHIYVTLSAVCIVLAAISVPAGQRAGSNARRRLHRELIASVLQNSIHFFQSVPLGRIMNRLSVDIAVVDKKIAATSQKLLQFILLCLCAVLINSVVTPYFILLTIPICGIYYVVQKFYRASSRELQRIESITYSPILAHFSETIEGVTTIRAFGQEARFMEVLFRRMEANNVAQIVLNCSNRWLGIALDYLGAVIVFVAILTALITASLRPQSTSSSLIGLAINYAMLVPIYLNWVVKLFAEMEMYGGAVERIQSFIETDIGSGRLRAARTGDDFPRWHRPFLRDKSVPISWPLKGDIVFENVSLRYENQKENIIANLNLTIPAGQRLGICGRTGSGKSSLALALFGALEVTGGRILIDDVDIAGLHTDELRSRLSIIPQEVMLFGGSVRENLDPRGHFSDLELWNCLELAQLKSIVHALPNGLDTKISDDKHYFSSGQRQLFCLARAILRGSVCLVLDEATSSLDTDTEKLVLQAAKKAFKGRTVITIAHRLHSLFDYDRVLVLEQGRIVEDGCPRQLAGATGSKFGAMLKANDHQQHSILEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH66</accession>
    <name>A0A084WH66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP008389-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017568</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH66"/>
    <dbReference type="STRING" id="74873.A0A084WH66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017568-RA">
        <property type="protein sequence ID" value="ASIC017568-PA"/>
        <property type="gene ID" value="ASIC017568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017568"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011619"/>
    <dbReference type="OMA" id="VIYLYHQ"/>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052792">
        <property type="entry name" value="Thioredoxin_dom-contain_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="798"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117622" checksum="D3D934F71289AE58" modified="2014-10-29" version="1">MNTLTQDLSAEDCSSSNFQQASSGSVATSSTQTIRHPSTRRQQLNTVPSRKVQQQARTAGGQSTVPQRRGPAYGDDTSDCSSAVSVGITGHPVPESEHSSKVAEDDNVAAGVEDESASDNSQLSGGGGALDEKTRRYNRISMIIVYGREALCILALILTTYATIQNSPPKISKAPPAVPFFPKGSLVHDWPTGALGTTQTRVSVSELSFVLYYAPWCAESQYARQAYELVAQLFYREAHFAAINCWQPGGECRQRYSKVQAWPVLMAYQSNGLAVQYHQAWTATAISRFVQSLMLPLHRFSNPSDLLDHMTGKDAVIVAFLEMANESKLYQRYYQASLKWLEKDPFQELSFGVVTGQSSKMFGVETVPSIRLYLWNETIEYVGNSSWTPQELIAWINKHLHVASMWLAPPGATKSATIAPYLQQGPVLMLFSPRPLYDDSSDAYMMLRQLSMQYYNCPGDAWILEMAREYIAEQRTLNAERFVQRREQCVRVLGRHPSQDDDEEDDTDGSGGRKYRRNRCKDGFKSTVSVSFVNVLNSSKFVDGKPVGKPVVDEYCDIAPAMGCGAHECGAFGPERRPSLRWNGGQDGCPAGSGKPVDSQPRTVTSKWDSEHDYRGPKRLAKQNQRRQCELLRLAETDGANVYYSEPAPSKNQSAEYYTTIMGLSCSQNKSLTFLSMDSNLYHAFGERLGVNVLQEPNRTVAFIIDHQDESTYVLRDRINLNTLAKFVHDYHNGTLVRFQRSGSIHYQHTHPFDGINAKKQSKQNLEKHYEQLERVAESKAQSKPSKKAEQRANSSPLPPTETNEQQQANLDATGKTTTSTKPNRNREHHSVREIYSSNFRRVVLDSNRTVVVSFYSTQCAFCNILSHHLLTVSRLLRQQPALEFVRIDGDRNELGWEFTMDVFPSLIIFPNGRKSESRIFPHTLKVNVPNVVGFVLSNLTPAERLHANFLLCGAVNKASRTDCLQMLKRELTESIRLSLREWRRRVSNTCERDRIVRRLQLLKQSYLGTLRCLSHSCDLTQLVVNERKLIQQLWTGSSSSPACVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHN8</accession>
    <name>A0A084WHN8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018386</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHN8"/>
    <dbReference type="STRING" id="74873.A0A084WHN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018386-RA">
        <property type="protein sequence ID" value="ASIC018386-PA"/>
        <property type="gene ID" value="ASIC018386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018386"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019671"/>
    <dbReference type="OMA" id="NCVSANI"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018386-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="379" mass="44284" checksum="36EBD18FA205BA9F" modified="2014-10-29" version="1">MTDRYQTLQDRVAELEKNRTATDDAFQELVERSTQEKYESLQSKLIELENNITTRDDSLQEIEASVKELERSIKERDEANEGKLIEIEKRAMKKDTILQEMMLNITRSAEKVTEIEKNLHAKENALQEVMRNMTRLEDKSKVRYEELEVNLNKLQNESKNSFDLQTAFIKNYNILRPCKETPTNASKIINLGNRQSVIVHCDQAPFGKGWIIFQYRYNGKVDFYRTWAEYRDGFGTLDGEFWLGLKYLHQLTTARKHELMVEVKDYNGNYGYAKYDHFEVGSEAQKFVLKLGSYSGTAGDSMTYNIGMKFTTKDSDNDDSSSTQCAEDRNGAWWHQSCTYANLNGPYGNLSGNKAMYWYYLKKDYRAIVYTRMMLREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI59</accession>
    <name>A0A084WI59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP012016-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017933</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI59"/>
    <dbReference type="STRING" id="74873.A0A084WI59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017933-RA">
        <property type="protein sequence ID" value="ASIC017933-PA"/>
        <property type="gene ID" value="ASIC017933"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017933"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019743"/>
    <dbReference type="OMA" id="KNWELRH"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06759">
        <property type="entry name" value="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055287">
        <property type="entry name" value="IL-16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484:SF2">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="762"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017933-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="885" mass="95623" checksum="D91971C71E1BAA9B" modified="2014-10-29" version="1">MPEVFSINKLWNEEERKTRLDGTNSNSAGILQKWSKLRRRCASFKSVSGPASLDSDTNFILAEHPGHYQIISTATGSPVQPRAAHVHLPPAVSHPGHNNNSPSQHHLLQDSPAPGYDPKNWELRHSSSSSASASSSSTIGAPPPLAASPPDYWQHYTPHEPSDVKLWRLGAHQTYAHRIHVNPPQRRSAHSIDWEYSVHRYESMCEQLPPPRIFRTEKLQYYDELAEVKVKPTVAPTAVGNGGPQPCATDGTPPGVKVAKEIKLPSLKTFKSASMRLPGQKSSIHEVQQLLRSKFNRIHAGLRKRRALSVQEVFQLPTPGGAAQATPTKPTFYVPSPLVSERTPHRNHHSVPRFSEEDEVNGRVGSPYDGEEDGADDALPHEEDLPGEDDGPVSLPYISESMLVTEPVTASKVNLRHADHCPSPRKERTKTWYRSIDFNGALQKLDAQRNSLDTGAKCTPKRPPEPEPATAPSKPPTIQPGDGVGALKPNFSIGGRVSLRERVENMNLSRLRPSKGGDRGSPTPSTPVAMVKKISDGRKIRPRSHSPLKNIKINLTPVKKGAGTNSQANEKPSKRESIGLFGRINRMMHQHVLVGGLSSGEKGDSSPRKTSNGKSPATGTPKNGTDDGSKEVKATAAVSGTPSTAVKGIGTGVGVSAIGGNVSKQSTIQKLTQLSSCNRREQQLQQSKTETAQERDRKSKQVSDSSLSNGHTKSNGSITFADTSGKLCLINPPDEDEGEDDEDSIEESKFCTLPRHGPNAFTIRQARFSKGNGAKVLGFSIVGGKDSPRGSMGIYVKTIYPNGQAAEKGTLHAGDEILSVNGTAFQGLSHQEAINVFKGIKAGEVVILIGRRNNRRKLETPSPTDSGNGTAPSSSPTNTITCNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKH5</accession>
    <name>A0A084WKH5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP006260-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018762</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018762-RA">
        <property type="protein sequence ID" value="ASIC018762-PA"/>
        <property type="gene ID" value="ASIC018762"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018762"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018762-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="10637" checksum="276BA9AC0EA14179" modified="2014-10-29" version="1">MDIDRHQFERPAFWRLPQTKTFELPYGRKRVHFSEQVRIRLLDEACLVYVLVYVLDVFPPWGKRKTCQLLPTDDAECTECKVVHRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKV8</accession>
    <name>A0A084WKV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019178</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019178-RA">
        <property type="protein sequence ID" value="ASIC019178-PA"/>
        <property type="gene ID" value="ASIC019178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7340" checksum="1BA96F6B35ECA1CA" modified="2014-10-29" version="1">MEHFNVLGVFFRGGCGEKVMGLPAVRTSHSHFGRLGDHPELMKNSFGPTRLAHPGLMVNRQVRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKX3</accession>
    <name>A0A084WKX3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019211</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKX3"/>
    <dbReference type="STRING" id="74873.A0A084WKX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019211-RA">
        <property type="protein sequence ID" value="ASIC019211-PA"/>
        <property type="gene ID" value="ASIC019211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019211"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002910"/>
    <dbReference type="OMA" id="PQQFAIC"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13476" checksum="8DEA61E0028D5558" modified="2014-10-29" version="1">MSRIYQAVVTTADKFVPGALRPLWNHAAGPKTVFFWAPVFKWGLVVAGLSDLRRPADQLSISQSASLAATGIIWSRYSLVIIPKNWGLFSVNVFVAGTQVLQLYRAWDFSRKNQKAAVAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL12</accession>
    <name>A0A084WL12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative TSD2 protein, required for DNA replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019254</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019254-RA">
        <property type="protein sequence ID" value="ASIC019254-PA"/>
        <property type="gene ID" value="ASIC019254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019254"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10073" checksum="9EDF769AA7E8F4C9" modified="2014-10-29" version="1">MLNSFIVRPECAPRATPEAIITNLIPKRADAASSGGCTGCTLSKVKQRGKPQANKHRARLRSKCKSCRTLRIYGTLGGPCEWRTALWRCWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM03</accession>
    <name>A0A084WM03_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00019290</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024337">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM03"/>
    <dbReference type="STRING" id="74873.A0A084WM03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019290-RA">
        <property type="protein sequence ID" value="ASIC019290-PA"/>
        <property type="gene ID" value="ASIC019290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019290"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003298"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB51247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019290-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19540" checksum="A08237FD582749B7" modified="2014-10-29" version="1">MASRRIAQSSINWAALAERVPPNQKANLAAFKTKSDKYLRSVVANPETAPKIDWAFYKKNVPVAGMVDKFQQAYEALQIPYPPDNVTKLVEAQEKEVQQEIAKFVKESEARIAEHQAQIATLKSLLPFDQMTMEDYRDSFPEQALDPINRPTFWPHTPEEQEPGAPNAEPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM72</accession>
    <name>A0A084WM72_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019369</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM72"/>
    <dbReference type="STRING" id="74873.A0A084WM72"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019369-RA">
        <property type="protein sequence ID" value="ASIC019369-PA"/>
        <property type="gene ID" value="ASIC019369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019369"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002788"/>
    <dbReference type="OMA" id="VACCDPS"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785216" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="332" mass="35823" checksum="E055D7C35B57B349" modified="2014-10-29" version="1">MKPVLMLLVGGLTMVVSGQTAVPWNCNLCPVGACVNDQRCPVVNNPLGPTFLPHPTNCNQFYKCSHGQACEYSCPAGLHWSQALQRCEWPNVACCDPSIECRPGCPEVCPAPPTTTTPVPTTTTTTTTTTTTLAPVTVTTTPAPIPTTPCSPCVECITDARCPLTDNPMEPTLLPHENDCTRFYKCAFGQRCLMQCQPGEHFSVALQRCEWPQYACCDPMIPCQQLPTPGDPCSPMPCPVLDCRPDNGCPLGDDPLNPLLLAVPGNCGAFYKCRDGDACLIACPPGQHFSRTLQRCERPEVACCDSTVACCVACAASRRHELNHLFGIKSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMC7</accession>
    <name>A0A084WMC7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019598</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WMC7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019598-RA">
        <property type="protein sequence ID" value="ASIC019598-PA"/>
        <property type="gene ID" value="ASIC019598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019598"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023242"/>
    <dbReference type="OMA" id="YDDGQMA"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000092">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1363"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1166"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1427"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1500"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1744"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="680"/>
            <end position="697"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="751"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="767"/>
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            <begin position="816"/>
            <end position="832"/>
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        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="950"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1012"/>
        </location>
    </feature>
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        <location>
            <begin position="1028"/>
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        </location>
    </feature>
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        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
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        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1430"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1749"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1793"/>
            <end position="1809"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1810"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB51371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1830" mass="192326" checksum="EE007ADC74106963" modified="2014-10-29" version="1">MNRTEKDTTRPAASSSSSSNSSPSSYQFLDLTDAGENDASTLMGILYPPHGPPPTSVGRPVGADDAGFGSASASSSATTERRAATAGAEEQPCTNGLNPNAQAFDPLLVLVMDESSGKARSRLVEEPLQMGGVPTVPFVAVRKPPRMPAIPNRPLILLDQPPPPIAAGSVLQHHLPPVPTFASQQQQQQPSLQAPPQQMHQHASFGHRSASIASAPTASAPLPTLGAGDGPGGRNSDRDSNGNQLQQQSLPPVSNHQQQVMPHVYTPIPASAYMQPGPHGMYPVQMLPQTVPNNVYVSNLTANVNVHGYMSHAISPYLATATPPGAYMSADVAGGQDLQLVQPSPVPMSTRGGMRRGGRNSRGGNNSRSRGGYMVGGAGQYGGFGAPYYMLSPHPAAQHATGAPLFMTTPHMPMYNYTALHGYPSMMVSYIPPEYSMYDDKGDDQSGGGQPGHDEGVLHAPGQMWPPGQMSLECNPEMGEYLPAGMYEPQQGMPPPMAHHHVLDPNVPGFTMQMAAAPVQMQDEYESLQQGGPPQPDDYNGNIHSSNSSMHSPVGVVTSVAQQQQHQQHNMAYMVQPQQDLGGQPMMNAVQMESEVLVEPDQQQPQQHHHQQQHQHQQQMMEQQQALPPMDASGGVNNNYVEQQQYIQSHPPPHFAGAAGPPQHAALQQQEQQEQEHLQHQQPHAVQHHQQQAAASAAINVTESPPVAFQHQAQQHCLVDADGNDGNNNNRKHEATSPQHAESVFITNTTPLPLAAVNMSNNPPPSSNQSTPQNQQQQQQQTAGAASNASGKGLTQHATNAANKMQQQQHLNVPNQTSQQQGGAYQQQQTAQPAQSAPIAGYAASVAAQDPTKAMEKLSLKEDRRAAVGSVAAAPPSGGEGGNAQRSGGSTVQQTPPPVAAGGSAWVANSGGIGPKKSTASVSVSAIPNKEFPGSAGGGHQQHKNGSPVPFTALGATATPPAPKQTTTAAGQKNFPDNHHQQRQHTTVSGAAGQQIVSSPAGGQQNTSSTAAPPQMESKKVEAIPQRSVSTTASSATSSTASNVAAPEAVTTSGKSTTQHHPNHSNDVVIVPTPATSNMVKSADNKPTVVINHPLNIPPPDHLLNIPPPIIVPPPQIPSGGPPPPQPNKTWASLFNSSSSSSSSSAASVMSSSSSVAVNTAASTTGLSSGAATSHHHPYSGPAQQHQQQTGPGGVNFAPPVNRAASAGGPALGPIVGQSAASTPVASSLAGSGSSPATDGGAGGSGSKKPVAKVQPYERGNLSATTGSGPMSYSSAAASTPGGAHTNTSASASVTASSGKGGKGGGSSGQAASGASKNTNSVSSSKDIGGATGGDQKDEYSLKFGDFLSAYRIENNNVSLTPRGLINRSNYCYINTILQALMACPPFYHLMRTIRTLHAAKNTKHPKPFIDAMCSLVGEFSQLPLRSKAQQREKPKKDDTPEIQVDTPFEPVGIHKILNGVRSDIFQVEGRQEDAEEFLGCVLNRLNDEMIEFMKLNKPDQAGVNGEEPTNGEVHGEDDDDWMVICGNRNKGTVTRTTDFGRSPISDIFGGKLRSRVQRDGVPPTYNIQPFFTLPLDIEKAASVKEALEQLVGRDELEGVTCSKTKQEVAAWQQVTLEQLPVVLILHLKCFDYKMDGCTKILKAVDFPIELKIDSKLMSSKGKSYSAKQKQYRLFAVVYHDGKEASKGHYITDVYHAGYGSWIRYDDSTVKPVPEFNVLRPRTPRVPYLLYYRRMDTHFLDTAAETGGRRGGASGGDGGSSGGRGGGGGSSHSSGGPERHNSHHHHANDHGRGGGSGGYGGANSYGSGGNHYANSGSGYGHSNSGHYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNB7</accession>
    <name>A0A084WNB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007494-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019800</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNB7"/>
    <dbReference type="STRING" id="74873.A0A084WNB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019800-RA">
        <property type="protein sequence ID" value="ASIC019800-PA"/>
        <property type="gene ID" value="ASIC019800"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019800"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002281"/>
    <dbReference type="OMA" id="AFQIQDI"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="67"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019800-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="421" mass="46596" checksum="A0808B69C3286E94" modified="2014-10-29" version="1">MCDASDGCQNVDKLAGCCHMKPLISLNTMTLQVESPTVYTSQGVPISVTGIAQVKIQGQNEDMLLTACEQFLGKSEAEIQHIALVTLEGHQRAIMGSMTVEEIYKDRKKFSKQVFEVASSDLVNMGITVVSYTLKDIRDEEGYLKSLGMARTAEVKRDARIGEAEARCDATIKEAIAEEQRMAARFLNDTEIAKAQRDFELKKAVYDVEVQTKKAEAEMAYELQAAKTKQRIKEEQMQIKVVERTQEIAVQEQEMQRRERELEATIRRPAEAEKFRLEKLAEANKLRVILEAEAEAEAIKVRGEAEAFAIAAKSKAEAEQMAKKAEAWREYREAAMVDMLLDTLPKVAAEVAAPLSQAKKITMVSSGNGEVGAVKLTGEVLQIVNKIPELVKSITGVDISRAVFDIASIDAVMGLHPEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPI5</accession>
    <name>A0A084WPI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP000662-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00020452</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPI5"/>
    <dbReference type="STRING" id="74873.A0A084WPI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020452-RA">
        <property type="protein sequence ID" value="ASIC020452-PA"/>
        <property type="gene ID" value="ASIC020452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020452"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017558"/>
    <dbReference type="OMA" id="NYHNFIG"/>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20026">
        <property type="entry name" value="FH_FOXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF7">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="479"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="479"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB52129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="702" mass="74203" checksum="60FB0C0FDE5996ED" modified="2014-10-29" version="1">MSSAAQECMTAPHGGDVKLVVRQEAVSPSPASINIKPDPNDFPSSGSSNNRHVLIAGGAATNYQKHQQQQQQQAAGPVPSSNNNYHLPSNASRARRMSPSSPVSSPSPTPPPGPSKLSNGAGKPAAAMYTIEGGAPVPAAAAAASSTINSATMMATGGGGGQGGGASNTANYHNFIGRLISKDNMLLISEDVIEVGRNSSKSQVDFHVGKNSFISRKHFIIQHDMNDEFTLFCLSKNGVFIDNVFYRKSDEPYKLPKLCSIRFPSTNIKIQFENLIDQANNGIMVDLNEHTPVVGGGAMGGVPLHAGSVAGAAIANHHHQQQVGGAAGASIGGAAAAAAAGHHHRRGGGKLPSSNVIYAPLKISIPSEQGAGSSGGAAGGASAAGGLLGDVNVRGQVRVGAGGGHGGVGGSGYPSPTGTISAANSCPTSPRQNTHDFPQYSSAHHHHHHAGHSTGGGGNNNNNYNEFQAPATQSLESDKPPYSYAQLIVQAISASPEKQLTLSGIYSFISKNYPYYRTGANKGWQNSIRHNLSLNRYFIKVPRSQDEPGKGSFWRIDPSSELKLIDQSYRKRRQRGSQCFRSPFGMPRSAPVSPSYTDNSRDGSPINEELLLSAPGSPGHNNSEYIPKKPRWSVAFPFANLHSFSYAYVTLVPPTGTQQTSYQNQYTAYASAEHVATVTFEDDEQLEYESDDYEPGHKRQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPR9</accession>
    <name>A0A084WPR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013381-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020323</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020323-RA">
        <property type="protein sequence ID" value="ASIC020323-PA"/>
        <property type="gene ID" value="ASIC020323"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020323"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008740"/>
    <dbReference type="OMA" id="YCYSDFF"/>
    <dbReference type="OrthoDB" id="7744853at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020323-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="723" mass="77114" checksum="D2856999830150B9" modified="2014-10-29" version="1">MPSKKRSPSLAEKECARKSISGPIDDDSLKRLNSNIFGNSINYFCDLSQNKENFITTSSFYVNDDDTDDYCYSDFFMTSSITLSSRKIKKLPKIQNIANHPRSSQSMSFIAADVNAAYRNFSLVAEAPYNDATTQQQQQQQNHQLSSGQQALTYYPELDEYGSASTTDRRLLPAGRHDSYADTNSTHSMSYGGGSGRKQQSAYAGSGSGQSGSNAFCNHNPIYSDQLDNNNSTNVGALMLLNGELGKAATVGTKKQLPVIQPPSSGGGGHESLGYPYKPQLYPTSSGSGGATSGGRDELGGSSSLQNGYGKDLQGYTTSGGLYDAGPGEMSSKRPTLMNDRVTALKSRSRSSTPVSSSGGSSSRSDYSTASKQQSAYDNAYQGYDAMNHVTACTGSVASSSAGSVYTSSMGGAYGSSAASSSGGGYGTTTTTTTPKLLPKPVPSSGGSSHKSNNYLSSPDKKPPLRRSPDRVAENMYYDDHQDSFLMASSEKDTYGGTGAGDEPRRSSYDQHRNDRAPYDLMDDVGESFGGAYDDDHYPDDDHLPIDTSNTHSSKKLPKVGHGSDGISKKQLHFFDEREECFDEELEELEQANAAKQQQHQQQQQQQGQQQEQQTGQQPGQQSTNGTAGSGVLAGASASTNALLEHGYDVKADKLDQLNGVTGSGANGAGGAGLTPGTGAPGDGAIVTDISKDITQQQGKRENFNARDKWLWAYDQIINNQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPS7</accession>
    <name>A0A084WPS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Homeobox protein onecut</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00020331</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPS7"/>
    <dbReference type="STRING" id="74873.A0A084WPS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020331-RA">
        <property type="protein sequence ID" value="ASIC020331-PA"/>
        <property type="gene ID" value="ASIC020331"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020331"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013617"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016561"/>
    <dbReference type="OMA" id="GNCTESF"/>
    <dbReference type="OrthoDB" id="10068888at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020331-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="524" mass="56050" checksum="A6170E614DF58E3C" modified="2014-10-29" version="1">MQQINMCLGSQNPGSVDSMMSSDFQTLSPMHDRDSPVSLSTNTSYATLTPLQPLPPISTMSDKFAYSIGGNICEAFPGIGSGSVGVNIEINSCYNLEKLGVIHSPVHLGSELDDGKGECILVSRASPLPSSLDDPRFLGGGSSGGGGGGKSSDHGRHPKDDSDQYTVGTVQYLDQHSDVVLHSGTNGSGPGGGGGGGGGGGGSGLGSVLAGGGKEHHQHHHHHQAVFLNKSFSSKTNNISDLNLCKEIVIDDVYDESELDHVKLEEKKLEESCNQQLANGIGGGGGGGGSSSSGGKSSSCVSLGGDVGCINGDIEEINTKELAHRISSELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWIQEPEYQRMSALRLAVNSKKPEEPEPHVMMGHTKKPRLVFTDLQRRTLQAIFKVCGGCFLASTLYRRCSSIRSWFKLLALLALGSLLKNLFSFFICCTFLGCRIAFSQLTLSPLAVPSLKEKKGLVLIGCEQLKIKGNCTESFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQM8</accession>
    <name>A0A084WQM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nef-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020770</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020770-RA">
        <property type="protein sequence ID" value="ASIC020770-PA"/>
        <property type="gene ID" value="ASIC020770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020770"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9582" checksum="7F1FE9FA0941E1BC" modified="2014-10-29" version="1">MWTKKAKPTWRSSAPFHPVRPTRRTPGSKAIAPIVRLPVSSTSSSHRRPEMDERWGMGGHFRHQPGRLAKRLGGQFPNGTFFDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRR0</accession>
    <name>A0A084WRR0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">3-hydroxylacyl-ACP dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021183</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021183-RA">
        <property type="protein sequence ID" value="ASIC021183-PA"/>
        <property type="gene ID" value="ASIC021183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021183"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021183-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8325" checksum="7A6BB69FDB46D0A2" modified="2014-10-29" version="1">MNDGKRPATKIGFLLGHRSNRAHEGKPCSDPGVDLPIHVTEWNADSAGLSDSLSLRGQALREDIGLRPQNPPATVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS34</accession>
    <name>A0A084WS34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007336-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021327</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WS34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021327-RA">
        <property type="protein sequence ID" value="ASIC021327-PA"/>
        <property type="gene ID" value="ASIC021327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021327"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022889"/>
    <dbReference type="OMA" id="MPSICEY"/>
    <dbReference type="OrthoDB" id="7475679at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="690"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1435" mass="153627" checksum="6385B770D941D87D" modified="2014-10-29" version="1">MEDVSIPEPVESVGPTEGCEAAGEEPQQQSDANETEQLEKILALQDGDSTKSSMESSFTVTDCNCSSLIERTDKLDANELQLDAKVSELIEDLIKPHAQELEQCGEKLRALTIGETTVVACTTGGGGGAVVGGGDGSDSGVEFGAGSGSLTDTGVLQRALSNNSAGYASSCCGLDGEPNGMSMSCNSSMLSYSSDIYDKTGSTVLCGRLSTDYCASEGGSESSSVTGGPVSSLRKAGGGCAVKKKVAVKEPPASRSPRKSTESVSSSGRSSSRSRGSSLGRSVSLNLKSTPPASALSVAAAARERARSRDKSVSSTGTTASSSMSGSVNRIQQTPSKPMPPPRRPLKPDSLPTGIKDSPSGQRVTVSRTPSITRGRTPLGTPTDDGRWPSVGGRGGPSCGGGNTTPRSTRASSVVPEGLSVKTRVGPLALDGPSKASTGSTGSPISLPSGVDKFATLPRRRKERSAEDLKAGAGSGAGSRSNSVTREQVSNRMAMSLYKKGPSATTTNKSEQQGVASNKSISSSHSRLGSMAASLSSSSAAAKKLFQKTKIYHETSVQTAITCQDVEDAFGGNARNIRIDAVETATKQTQSDIRDKEMERLEEKLKKITSEYTTLMSKLSEKSQLVTSLEQKLLVEREEKLAAQRELQNNTDRVLGMLESMQAIPNNADTGDCDSLLMLESQLQLSGTVLEKKQDEIVRLQSICRALQMDMERSLKNQEELLRQKTELEEESSEMQDFLQVEKQSCMDALKEAEQEVALLRQSLQQRENSIERQQEECRHLVRISEQRRQEYLGMQAKYNALESRSKDILLQQGAAVSGASVALSGLGSRLDNLVEQLIASYNISEQDLEDVIYHNEAYTNSASSGDGSPEYEQTSDKYPSDSKHQQHLQHQQQSQQQVAPLSPQRGQSFIAAVISAIKNATSKTTSVKPAVATNGAGAGHVTKECRESNGHESDSTEMLDSETEPCLMMDNVLEDVTMPDSHSHNMVSSSTRISQIEMPSSMESGVCANAPGGNVMMAHDESLDNLSQAIANRQQIELQSNMIASGRSSRFHHSTSSDQQARNSAATMASSVAAGGAITTATQDHTTASHSSSLDDDENSCCAEASMAEMPSICEYCNAQSLVDQVIDVDNLITKLLKVLRIVQMDNDHCIQELINHKNKLAISNEEIHDRVKEYEELNYKLQDDLKDAYHQLQLRGSELNSNKVELVKHRKEIDKLNEDICQLSTLCSDSKQAKKIVIDREEILNAFKLCNEDEAVPEQELSQFIVQACTEIPKLKTMLYEKEQQLAKMASNASNSPNIVMTASWHQALSEAKRQYEAIDRALETLDSVKSIVQQTPALMELQRDLEETNFASASSFPLVTAAQLNHLNCAGANGNIAGGLNGNGNGIIDLNANETTTMGDNVAGGVAGAPAAVAGLQLSQGADASCYIDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTH3</accession>
    <name>A0A084WTH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP004377-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00021745</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTH3"/>
    <dbReference type="STRING" id="74873.A0A084WTH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021745-RA">
        <property type="protein sequence ID" value="ASIC021745-PA"/>
        <property type="gene ID" value="ASIC021745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022574"/>
    <dbReference type="OMA" id="CFMNYKM"/>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="408" mass="46529" checksum="334E86FFEA35CE40" modified="2014-10-29" version="1">MGGCRCTFRNCENGTASRKELHYFRYPIRDPERLKEWIQLANREEFLNLPKDKLGNKVVCQEHFERRMFMNYLCDRLTRFAVPRLMRQSDGTVLNLKTGNIQLNEDDNDTVELTGDLLKLYTPASQREQIKFETVQTLDSWKESSPEPAPKKIKILNSETLVPGKSDTACKLIRISTTPTQNERHIQVTRVPGYRAAFQLKSKSAKMIQKIEPTSDSDSHTYLEAQDDSNDPDEPQSEKPLSTNPDGDQDLSRSTVCVQVPAQTPVVDPLLAEKMERNSNEIMELKQMVKELLDRPPPKPQPITMVAPPAAPQKVVMAKGPHLTKAQLFSSIKRYLNPTMVTLLRMELFSGPSERQWKPDEKSLAVDLLNIGENVYDHFTEEFRFRLPPKADAQEWKAAGELDADDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUA9</accession>
    <name>A0A084WUA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022041</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022041-RA">
        <property type="protein sequence ID" value="ASIC022041-PA"/>
        <property type="gene ID" value="ASIC022041"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022041"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022041-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17560" checksum="621387D6AD5B7974" modified="2014-10-29" version="1">MFCLRVFRRKSYASDPKTAAPAQTSLGKAASVCFRCRAATERRKAPLDGTESEVDHRLFRKPRASHTQRKAAPVENGEHLGTFGRMFRGRQKPKHNAVVVCAVVYTSINSFRNRKRNLTGCEKTASHYSLVNSLSGNSIQVKGENFEREKTAAFSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUG1</accession>
    <name>A0A084WUG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010680-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00022295</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUG1"/>
    <dbReference type="STRING" id="74873.A0A084WUG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022295-RA">
        <property type="protein sequence ID" value="ASIC022295-PA"/>
        <property type="gene ID" value="ASIC022295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022295"/>
    <dbReference type="OMA" id="RRNSLYW"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="982" mass="112205" checksum="A2979B9F732184FF" modified="2014-10-29" version="1">MQVTVSPANNAKENLSWLTNQSFIPLFASNEEAKDDSSSEDIREENVSQGRDDTGSPSEKDRLSKKRKKKHIKKHKKKRGKRRSRSASSSEHSESSSDTPSVGQASVRISEAEYYTDVDPLKIYLTVEKLHRPACPRYRLATKRPLGAKDFNRKGTSLERHRRYYRVSRKETSKEGAKQSQEEILSREETLERSLRTDETVDKWIELIRYRQEHPIHLDSYQNHKRELSLVERARRHFPADDRLLHLYLDAIVRVHPTDEVLDLIRRAIVKDETNVTLWGALIRNKQCAMAQCIVPDVLKLYEKSTRSLFMARRSDETMLQLFKNCATFCRQAGLNELMFGMVQLAVSMNVGGRFASEGGGLFSSPEHFPQLIEYEELILRSGLPMNEIWLRVELLRSAFQYLPFAGTARLTSDPQRMVLNDDVIGFVYPLINKRYSFELTLTVLRLLKFPFASSLPAEDLECFREEPYESDYSEQLLPLLLDVYRNCALDHELYALIKQLSVAPSYIGANLAHESYVELVQQFLTIAIDHFEGTQSAIFLILYLQLQRMLVASEKIGARELGEGKIKAIRARVKNVLKHTHSSNQNNLLVYAEYGLLEYEMTGITSGTCRKIFTTSVQVYCSNREEGQNNSTEDDIDTDLFALVLTMVDMLLVTGRKVEAVEALTNLVLSPDKLNFEGDKRETSTMEPPDTVKLSTLQKLNERVNRGVRKETELGAAPLTVEQHLQPNGLLGSIKAYVIYLALVRSSLSEAIKQLETFLYLFNEPTNPRHRYLRNGLYRIYLQLFQIGQVCGNRAGPTHQESIRTFLDVADRTLGEFPSCLYILQSVIFNPHLPWFSLRHVVGQRLTPKGVLLLVVAARYRASLANQADQTEEIPYKRRILNLLGGAVKSPVSFLHQNALLWRLYLRELFDQPNAPPGVSVLDQCRRTLYAALEACPWNKALYLDGSTCAPQELSALLDLMMEKQLRVHAIPEELAILRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUI3</accession>
    <name>A0A084WUI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00022321</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUI3"/>
    <dbReference type="STRING" id="74873.A0A084WUI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022321-RA">
        <property type="protein sequence ID" value="ASIC022321-PA"/>
        <property type="gene ID" value="ASIC022321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022321"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016666"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06741">
        <property type="entry name" value="PDZ2_FL-whirlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000167">
        <property type="entry name" value="whirlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB53877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="210" mass="22710" checksum="D4E5361E57C8D1E8" modified="2014-10-29" version="1">MTVRAPPSAASMLNSSAPLHGFGPPPGVPGSRVAGDLVPPPPGIYPPPPNRQTCSWMDRQGRPASPPYEYGGRRPERRDRVRRVDLLIEPGQSLGLMIRGGVEYGLGIFITGVDKDSVADRAGLMVGDQILEVNGQSFMEVTHDEAVSQFKFHKRMSLLVRDVGKVPHSCTTVEPEPWDAYSPTGDAKEMSGVGDGRRKSQILITSSSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUK0</accession>
    <name>A0A084WUK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00022340</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="ATLV01027094">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUK0"/>
    <dbReference type="STRING" id="74873.A0A084WUK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022340-RA">
        <property type="protein sequence ID" value="ASIC022340-PA"/>
        <property type="gene ID" value="ASIC022340"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022340"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021800"/>
    <dbReference type="OMA" id="KVWECRL"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000373">
        <property type="entry name" value="Neural stem cell-derived dendrite regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="381"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB53894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022340-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="686" mass="77254" checksum="B6302D5399BC5DB9" modified="2014-10-29" version="1">MPALRLFGRKWLAASDDLVFPCVFEICFRIVWLGLISCVTSTYWNVTEECGEDGLPVRIYLVGTIVLISVNIVLLVLLVNRSAQGSITEVHKRRLVAPLLVIKILLILPETGLNVLGTMWAFCGTFQCRSNDKVSRTVIEAIVLFNWVVFALIIFGLAIVFDPLGSAKYKNGRDTNDNGPTESAIHRKVSKLWFRRFRWAFCCLRRDEFGHEAFTQVASLLSALFRGTDLVPSDIVAGCVLLRVRQKRETREMRRIRMLNDDGPRYSTDITRVFATSPAWMTIKNARHFLRFALAAYGWPMVCYLNCCTGPYRLIPKMTCCACFRRKPQIIIDDNCCLCHLAGVRYTSRLRSEDVLHASFKNHVFELPFCILADHSTKSIVIAIRGSLSMRDVFTDLVANAERFEAPGMPPDSSAHRGMVAGVDCMLKRLREGNILERICATFPDYTLVLTGHSLGAGVSILLAAKLRPRFPDLRVYAFATPAGLLSREAARFTESFAFTIGVGDDFVMRLGVDSIENLRTSVIETIRACKLPKWRIMLNGFGYALFGVPSRDLETTWHDVTEITAKKASESPLLSSERPIQTVATAEGALLSSEISQRRFAKTRLYTGGRILHIVRRKKTELEKKSNSGGPTYEMRWATAEDFTELKVMPRMLLDHLPDNVFKTLTTILEDQKTHNGSILSLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCI0</accession>
    <name>A0A084VCI0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00002574</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01010759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524612">
        <property type="protein sequence ID" value="KFB35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCI0"/>
    <dbReference type="STRING" id="74873.A0A084VCI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002574-RA">
        <property type="protein sequence ID" value="ASIC002574-PA"/>
        <property type="gene ID" value="ASIC002574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002574"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006170"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
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</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Neoptera</taxon>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783386" evidence="2">
        <location>
            <begin position="28"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="661" mass="74521" checksum="4B3561F158512BFD" modified="2014-10-29" version="1">MAQRSGCSAVLRVVLILVICTASEVLGQLSVLNQIPYGLLEHLKQAPQRWNATSATDQVCLNQLGTFANSFDAGELWALSMFDSWGKNPAGVLYGNVFAFGNFDQCRAIDHQGALSKVRGQHCTLYVDLSRVGVPVPAPLQYGVCVPDTCEPALVAQLTNAYFMANQMFVGNGQMLDMFCYRDEDRPFPAVTIVAIVLFSVYGGLLLLATVVELFFIHHKQDTPSIVKRFSAYTNLGHIFRINPRTEGKDSGVLECVNGIRALSMLWIIVNHVHDSALGIPTFNIPVRHEYTESYFGALFHRLGGKAVDIFLMLSGMLVSMKMLRELERTKRLNVWELWLHRIVRLTPAYAALILFGIAFVELVGEGVLAKLVADELQSACTKSWWSALLYVQNYAHHASMCFPHTWYLSVDMQLYIIAPLLIYPLWRYGRRFVPVIVLLALLSISCVFATFMVNEYRLNRSAPRGDGLMPRKTYHPTHARMSVWLFGVLFGYLLHRTRATRVKLSLPALGLGWLITAVILVATGYSLKQLYTGDYTRIEPIADAFYESLHRSFWAFAVMWVIFVCINQQGGIVDRFLGSPLWQPLSRLSYSMYLVHIAIQAVTLTKAIRFPVEFTVVNVFYTSFGLIGISAVVGTVWCIAFEYPFFGLERYVFRRKRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEK8</accession>
    <name>A0A084VEK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003568</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003568-RA">
        <property type="protein sequence ID" value="ASIC003568-PA"/>
        <property type="gene ID" value="ASIC003568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003568"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="13033" checksum="1D84B8C36F07FDCE" modified="2014-10-29" version="1">MSDFSPTRYVKPFAMRSELKSRKRLPVLDGSCSMEAMDLEASLTFAHFCVAECVFPVEGKAQQRAEESAEKTQHLMKWISMVSYPPGERLWSRGPVRFRSNNGGNVEQQQGQEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEQ5</accession>
    <name>A0A084VEQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP004303-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00003487</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEQ5"/>
    <dbReference type="STRING" id="74873.A0A084VEQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003487-RA">
        <property type="protein sequence ID" value="ASIC003487-PA"/>
        <property type="gene ID" value="ASIC003487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003487"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004585"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006196"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021797"/>
    <dbReference type="OMA" id="VCAPRFI"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001422796" evidence="13">
        <location>
            <begin position="28"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="402"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="464"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="659"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1116"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB36449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125816" checksum="C01D7FEB77F3E715" modified="2014-10-29" version="1">MKSPTRITSAVTLAALLVAFFLGTTGGFNLSPMPNYVFQEPTLQMFMEKVRSSYFGFSLNLRPGGVIIGAPRAQSDLATQRKVNETGAIYRCRFDDGVCAPYYFDKQGNTFAEQSDFAYNSEKKDYQMLGASMDGHGSDGDRFVVCAPKAISELVDYYLLHGICYITDGTEPMYNEPKEVRKIIPLRAKDKQLYKLGPVQFYNYMYGEQGVSVHVTDDGEEVLIGAPGVFNWRGTVVRYKKRVSDDMGGLSRRDALEGGHRHSNRHRRQIVQYVSDVPNPYFSTLQDDSYFGYAVSSARFLGDAEKTLYVASAPQSAGQVGEVFIFDLINADLFVETQIKVYYTFPGQQQGEYFGYALLTEDFNADGLPDLAIAAPMHSRTGDHDNGVVYVFLNEGQLNFQLQTKLSSGYDLAGRFGTALAKIGDINRDGYNDIAIGAPFEENGAVYVFLGTADGLQSKPSQRLTPPANELLTPQPMFGHAISRGSDIDANGYNDLAIGSPNDEKVYVYRTYPVVRIAPEVSSSKRELTLEDTSFELAICLEAQFSAGTPFDVQLRYSLSVDAQLGRVTLPGGVGGRRNETVTVTSTTECQRIEVRLKATAASIYKPVIVELVYELVSQPPTGDSGERGEFCPNCALLDPTVPNRVFQKISFKTGCLGEVCVSDLRLTSRWLDITPVYVLGSTKKASIEFEVYNAGENAYLPQLNVTLTPARLKLARLTSECRQTETNDFVNVVCDLNNGLPLRASHTAKYTLILDMTRLEGTSAEIRAEALSSSEESAQDDNFLEETLTLQEFSDIEIIGKTSISELYLEQQSGVQNISYEIQVHSNGPSMFRNLTFTLDVPLVYHKPSSGKSYKIINFNEIVVQGLYSYKTLEYEWTQNDVTLLPNPIEHSSVRPGTVDVDALHRQPSDFDLLSNGGGMDHDSMSLRRRRRQTSDFNRYSGQVEEHSRVRRSLAPMNNAILQGLPGNRTLFFSCSDDDSIAIECARLTVLVDLFRPTNVPISITINFPLDLDAIDEAFLEREDIFALVMLADVQKKDDPSGSTFQLTRSNPFTVVYRYSDSSTPIWVYIVSALGGLLLLGSITYGLYRAGFFKRATKEEMEKLHRESTRLNEPEPTSQSPAEPTTELQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEU8</accession>
    <name>A0A084VEU8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003622</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524780">
        <property type="protein sequence ID" value="KFB36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003622-RA">
        <property type="protein sequence ID" value="ASIC003622-PA"/>
        <property type="gene ID" value="ASIC003622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003622"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9411" checksum="CDC0035E08BA74AC" modified="2014-10-29" version="1">MNVNAMHISELLERLLLPSVAFAPSMQLQNPELWLGVLANPFSCSVACLLLLRSLSVATMTCPCVPKTTINIETQSKSGRYLYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFI0</accession>
    <name>A0A084VFI0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003891</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012409">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524791">
        <property type="protein sequence ID" value="KFB36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003891-RA">
        <property type="protein sequence ID" value="ASIC003891-PA"/>
        <property type="gene ID" value="ASIC003891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003891"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="15958" checksum="4C04439020352A71" modified="2014-10-29" version="1">MVYQKRTQPPLRTDSSVDARSASFLDDGKAKPNSEFEYHPHALKCGVITWKCVLRRGTDQPKSGHSAGSACGQQPVSTEPGSAVGYAAKKPIMHRCCTRWSFTGNGLAGYTIWRPNGEHSPLGSWVRFLICSPVPPGPRGWWMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGZ5</accession>
    <name>A0A084VGZ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000342-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004454</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGZ5"/>
    <dbReference type="STRING" id="74873.A0A084VGZ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004454-RA">
        <property type="protein sequence ID" value="ASIC004454-PA"/>
        <property type="gene ID" value="ASIC004454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004454"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009629"/>
    <dbReference type="OMA" id="YTLWAFT"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="7">
        <location>
            <begin position="203"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB37239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="341" mass="38649" checksum="D89CDD1C130D79A9" modified="2014-10-29" version="1">MDGTMRVYNATLWIRLELKLKAKKANKGAAITGNDNHWIHGANKALVLWVFRIINGSKPAETMSKEEEFSKHTEMIAKHTIPLESGLGWQQIDLTSAVRQWHGEKRNDSLKLFVDCSGCGNKIRVHIFEHASNHHHLHHFSRVGLYDSKRQKPLVMMNGAPRSMVKTKYPKSQEGKAAYREVTDDDYNRPHLFVSIATTQVRRLRRRALDCSGAPNEQCCKQKFYVDFKALKWDDWIIRPHGYYANYCKGSCHLADKFSTEYHYVIDQYRRQGNSGNRGLSKMHHKSGSGANGGGGSGLAGIHQCCAPVKYSPMSLIFYGPDGRIIKQDLAKMIVEECGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI96</accession>
    <name>A0A084VI96_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of split malpha protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004940</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013337">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524853">
        <property type="protein sequence ID" value="KFB37690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004940-RA">
        <property type="protein sequence ID" value="ASIC004940-PA"/>
        <property type="gene ID" value="ASIC004940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004940"/>
    <dbReference type="OMA" id="ADRDLCY"/>
    <dbReference type="OrthoDB" id="8190494at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029686">
        <property type="entry name" value="Malpha/m4/m2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254:SF0">
        <property type="entry name" value="BARBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254">
        <property type="entry name" value="ENHANCER OF SPLIT MALPHA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15952">
        <property type="entry name" value="ESM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21212" checksum="3CA50CD39187EECA" modified="2014-10-29" version="1">MHSYAVNSNNFAANMAASSNNSINENLYNNEKLAKSSAVYKLKKILKPLVTLLKSKKELSGKQSTAAQKRLARDQRKSVISYIDEYDCDYDNSANERLEAQLIAELEDCRAQNAAIFVYEDQQLQLQPVQPEELYVPVHFARTEAGTFFWTAMPVREVDEDLIQPAHCYSEEQHAQQAYADRWAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIF9</accession>
    <name>A0A084VIF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011685-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIF9"/>
    <dbReference type="STRING" id="74873.A0A084VIF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005067-RA">
        <property type="protein sequence ID" value="ASIC005067-PA"/>
        <property type="gene ID" value="ASIC005067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005067"/>
    <dbReference type="OMA" id="PENMSSK"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF11">
        <property type="entry name" value="PROTEIN UNZIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783421" evidence="2">
        <location>
            <begin position="35"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="516" mass="56454" checksum="43FF23C3F265547F" modified="2014-10-29" version="1">MTNVRWQMGSRQRAAAVILAVLSCVLLAPAPSAAFAHSVFKALAIGTSTQSVTSSTLTWEKFSGVEDHLQNAVRVAEPEKDSKEHVENDHVPPPSYVCRVLIEGMHTAGQTVKDESGTICTVAAQQAEVERHHAFEILINMGGGGRLIWQSWDRYHAGIFGGAVSSGTGKSNDYYVARVRPGHGAHQQHHHHGHNSYVVGNFDPSISLSGRIFAPLPDSKMSTIHEQGEILVEIEPVKYELHQIKLSKVKTIVKKNATVLGSTILSNTDDKTSQAETVITYDYKKEIYWGKHQGVVQGLNTKVFDSRAPQSTNVTWGMKNSERRFETKAVNTVLEPGTAINVTLFGNYTEMEAPYTATLKAYYDDNSDPVSRKITTTMVSRDMEDVKIEFSPVYWIENGTLVPTTTTTTTTTTTTTTTTTTTTSTTEATTSLRPVPINSTPTEGGNVIDEDGMSNEIGHAPSTSRDMKDIQSGPKADINKHADHSQPSAGVRTSAFTQPMSSLWLLLAVMLLFQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIP0</accession>
    <name>A0A084VIP0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005003</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01013376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIP0"/>
    <dbReference type="STRING" id="74873.A0A084VIP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005003-RA">
        <property type="protein sequence ID" value="ASIC005003-PA"/>
        <property type="gene ID" value="ASIC005003"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005003"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004027"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="420"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005003-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="670" mass="74793" checksum="226601DE44F008E2" modified="2014-10-29" version="1">MYNSACSAAAGGCSEPERHDRDGLITHETAVAPVEHDYSGFDIVKATQYGAIARVKELIEAGWDVNQPDSETVTLLHWAAINNRKDIIKYFLDKGAIVDAVGGELNATPLHWATRQGHLGAVVLLLAAGADPSIRDAEGCSCIHLAAQFGHTALVAYFIARGVNPDLQDRGGMTALMWAAWKISALDPVRLLLTLGANPSLADHTHGNTALHWAILARNATAVSTLVLKGKANMEVPNLRGDTPLTMLQPHVGSIWIGSKVSDRIRELTQQSQRRNPFVRMTLDKRFRWWTMIATPFLVFYLAGLIFCADTLIIIKVFLIGCLYGVAQTVGQHLFDENLMALLPLSVYMATKLWFYVTWLTYIAPTVSFLASLAFLTCSAGLWVCFLKSWRGNPGVIQPTQEQRFRTIIELSERGATGFEPAAFCSACLVRRPVRSKHCSVCDRCVARFDHHCPWVGNCIGAKNHKYFMGFLWMLLVMCAWMLYGGANFYVQTCDFNMDGGLWSALVAIGSCNPWVGWVMGNALLHMSWVTVLTICQSYQVVCLGMTTNERLNRGRYRHFQAKGGKSPFNRGPLRNLFDFLECSCCGLVQPQRTDWMQFFEFDKHVEHEPLLRPDNFHSNYYPNDRPPPPPSTGSRRRRRPPNPERELAALMKSQAISAMLKSGSKMKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ35</accession>
    <name>A0A084VJ35_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome c biogenesis protein CycX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005152</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013429">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005152-RA">
        <property type="protein sequence ID" value="ASIC005152-PA"/>
        <property type="gene ID" value="ASIC005152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005152"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11606" checksum="9E5AE3F27EF8997B" modified="2014-10-29" version="1">MGGVYVLRAESASRTISGALIRGNPAHAHTIMWSPDGETDESALSLPTTGGPTILGRNRGAGNRTRRRGRHRLKSPDRWPGRDRASSPSGAGTYGDIGVHSYYANYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKX0</accession>
    <name>A0A084VKX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Copper amine oxidase, amiloride-sensitive</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005993</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005993-RA">
        <property type="protein sequence ID" value="ASIC005993-PA"/>
        <property type="gene ID" value="ASIC005993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005993"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005993-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12352" checksum="06A5F8CBAACAFD71" modified="2014-10-29" version="1">MVLDHPIQCLHRIKFLTFGSVSYPKCRNVLAQGAHDWSTNTHEHGAYESTQKIEQVAIRHVPHILPVGGQKKLNNAGERYADVGTHLFPLDDDQSVGRRCPAGTLLCLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKZ1</accession>
    <name>A0A084VKZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00006023</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524960">
        <property type="protein sequence ID" value="KFB38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKZ1"/>
    <dbReference type="STRING" id="74873.A0A084VKZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006023-RA">
        <property type="protein sequence ID" value="ASIC006023-PA"/>
        <property type="gene ID" value="ASIC006023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006023"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012734"/>
    <dbReference type="OMA" id="WLFANEH"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783735" evidence="6">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="501" mass="56898" checksum="28CEC65CC793ADC7" modified="2014-10-29" version="1">MGRSALLLLAIVASVVIVLTSAKSLHPAKSLPHLLDLLHPRADHLVPRDYVSTRSEALRFRTRVDHFNVQNRATFEFDYLSNDEFYRPGGPIFIVVGGNSAINGYFIENGLFHDIARREGAWLFSNEHRYYGRSAPVEDYSTPNMRFLSVEQALIDLIEWIYYLRTEVVRDPNAKVILHGLGYGGAVAIWARQRFPNLIDGAYGSTASVIARVDFNEYGEDMGNTLRTFGHDDCFGLIWRGFRTAENLVDAGLYDRISEMFRSCEPLQGSDPLSVETFFFSLKGSLEAEMFGQATYESVTRLCAELEADPAETALEVLANFFERRYGAFDCVPYDFESNIESALYEEVGVPTNAEFGIRQRLYQLCTEFGWFLTSSTGDSPFGTRITYRYFIDTCRAVFGDWVTQEIVYEGVRLTNLHFGADDPRVTNVVFVNAEFDPTRFVSITNYTNTFANAFVIDRAVVALDWMAPTVNDPEAIQRIQREIEYYINLWVTDGFGPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL41</accession>
    <name>A0A084VL41_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP008460-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006082</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL41"/>
    <dbReference type="STRING" id="74873.A0A084VL41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006082-RA">
        <property type="protein sequence ID" value="ASIC006082-PA"/>
        <property type="gene ID" value="ASIC006082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006082"/>
    <dbReference type="OMA" id="YENAQYV"/>
    <dbReference type="OrthoDB" id="7744015at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031874">
        <property type="entry name" value="Cuticle_Acp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12336:SF0">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15955">
        <property type="entry name" value="Cuticle_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="174" mass="18231" checksum="D4F10802708535D6" modified="2014-10-29" version="1">MKVRKIIPVYHEEDIRGSLILSILSFPEQCIAAVVIVALVASVQAGLAYNPVYTVPQATVVQQNVVPKYVTAYSAPAVTYASYAVAPAVSYASHVSAPVSYAAHNTVIQAAPVAYAAPTAYAYENAQYVPQVYASVQKEASYVAATRGAVHVAPLAGHAVNQKSLNVEAAPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLC2</accession>
    <name>A0A084VLC2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006168</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01014444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLC2"/>
    <dbReference type="STRING" id="74873.A0A084VLC2"/>
    <dbReference type="ESTHER" id="9dipt-a0a084vlc2">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC006168-RA">
        <property type="protein sequence ID" value="ASIC006168-PA"/>
        <property type="gene ID" value="ASIC006168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006168"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004298"/>
    <dbReference type="OMA" id="GYNDAES"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010751430" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006168-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="562" mass="62578" checksum="333A40E0C7DD977F" modified="2014-10-29" version="1">MLKFAVILSLLAIAAHAQDASRPIINTSGGQIQGVTSSCGLFCSYFAFNGIPYAQPPVGDLRFRNPRPHQGWQGVKDGSEHRETCPSGGFLGGVSGSEDCLYLNVYTQNLIGSRPVMVWIHGGSFTGGSGNSWIYGPDNLVPEDVVVVTINYRLGILGFFSTDDVHAAGNWGMKDCVMALQWVRQNIAAFGGDPNNVTIFGESAGGVAVHFLVLSQKASGLFHKAIAQSGTALLPWAFQYRPRELAYQLADKFGYSHDSAQLVQSLRNTPIESLINAQNGWLDIPIPRGFKPFDFVPNAEPVNSPEETFLTQLPIDILNAGTFNHVPFIAGYMSMESLFMVYEHTIDSTVWQAFTQNPDYFVPHFWNIQHGTAASAAVSQGFRNAYWQDRPLNDNIMVEWLTFHTDQQFIYGIDKTVRLHAQRSTAPTYYYQFSFDGDLNLVKRLLLLGSWPGAMHADDIPYLWSVTDLTISPILPTNHARTVSNRFVRLFTNFARFGNPTPNAVDTLLQSRQWLPVTAATVNYMDIGHDLTTSVNPNGQRTSVWRDLESRYANDPFRFPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLW2</accession>
    <name>A0A084VLW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009405-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00006482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLW2"/>
    <dbReference type="STRING" id="74873.A0A084VLW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006482-RA">
        <property type="protein sequence ID" value="ASIC006482-PA"/>
        <property type="gene ID" value="ASIC006482"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006482"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018632"/>
    <dbReference type="OMA" id="GDETKCG"/>
    <dbReference type="OrthoDB" id="9991479at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF98">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006482-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20025" checksum="8C42D7B55E730FE4" modified="2014-10-29" version="1">MQRTSACVFLQDGEPKRQLCPDGLLFNDKASVFAYPCQYPIDVDCGSRTRTQPAIPTEDCPHQFGYYKVGDRANCGQFKNCAGGTAYVLDCPTGLAFNAATYQCDWADLVEDCDAEAFLGFRCPPQAPGLVQPVRFFRAPDDCRKFFLCVDDRPRLNFCGPDQAFNELINACDGVANVTGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM34</accession>
    <name>A0A084VM34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP009339-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00006738</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM34"/>
    <dbReference type="STRING" id="74873.A0A084VM34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006738-RA">
        <property type="protein sequence ID" value="ASIC006738-PA"/>
        <property type="gene ID" value="ASIC006738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006738"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002303"/>
    <dbReference type="OMA" id="PRQYNCK"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF79">
        <property type="entry name" value="ASPARAGINE-RICH ZINC FINGER PROTEIN AZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="787"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="902"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="973" mass="113127" checksum="965ADD676CF50710" modified="2014-10-29" version="1">MPKTGELMRCCICCKHKANDDLYDLAISVDMSNGKSSCTIAEMIETVASIKLKPVPQSICESCWSYVNEAHLIRDQIRRSKYLQRCSESEHDNDTIVEIAANFEILAEDSSVKFPDNNLPEEDYESEYLDEYLEPTKSDDHTYDNPRDEEAVHEEEEEVEEECANPKNIPSSKSILLDASVVQEKTVLGVPCPSDLHITRQFVEPRSQFILRDEYHTQYRLLEVTGERCCGCSFVAGNRKELLQHSETVHAIDITDIGDYCPMCFYKFATDRHLERHMEEFKSTLIYVCLQCNRFYNLRQKMFNHLLKCGESIDVLSPDESDAEENENPDNDEEYYEEIIEDTYSDMNSPVNDSLTEAYQRKMMYCRALFDEIVSNGTSFSCKLDEAELNVQDFQIIDQCSFETFKFVRLRGERCCGCSYTCATREQLMQHGKVMHVADKIIQDDLTCCLCGSQFHEESEMVRHLSFFTSKELFFCTICHESFLSRESLKTHQQTNESHIEMFGSGKFVELDMPLVMEQLDRLQAEKNINRPKYIRCIPMPEERFIQNITKYKNYSVLTVVGQRCCGCGKFFDTLTDLKQHSQQEHTTSIASSWISDQLQCDICYAVFDFERGLILHKSTRRNNKTNLYLCKLCGLLFTKKYCLARHMQFAPNHLSELIVHASGRGASESVEVEDEKGPEDTEMNDPPELDPRVSEALQLHKSVQRAGLEKVGHFVGYHCCFSKCTATFSNEEDLVEHSRDEHNGKRLENETERKSDKNVCPSCCKSYQDLAKLSWHRFHRFIPRQYNCKHCDKTFDKYPKLKLHVDTKHSESPSNYVCSVCDKSFVLNSRLKAHMKLHTTQKDYACDICGDKFRSNGLLKRHRRSVHSTERPYECKHCPKRFRVIEKFKIHQRVHTGEKPFECTYCQRTFSHFTDRKRHIMTAHTGERPFKCSYCPAAYIRNRELTLHMQKHKDIVQNEAGVMKQESCYESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNL2</accession>
    <name>A0A084VNL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101248303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006901</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006901-RA">
        <property type="protein sequence ID" value="ASIC006901-PA"/>
        <property type="gene ID" value="ASIC006901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006901"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006901-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11762" checksum="2E50F8EDA5F391FB" modified="2014-10-29" version="1">MLLPIEPERATEEGDERKPAEEKYYGVPAIATTSNEAERTRKVEDLCASLQIARRSRRVHREGQAGAVHTFLLTSLHSPGPYDVPNVLRTLTRRTSSGLVFASVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNN1</accession>
    <name>A0A084VNN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002040-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007023</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524988">
        <property type="protein sequence ID" value="KFB39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNN1"/>
    <dbReference type="STRING" id="74873.A0A084VNN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007023-RA">
        <property type="protein sequence ID" value="ASIC007023-PA"/>
        <property type="gene ID" value="ASIC007023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007023"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001311"/>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="25796" checksum="B2D62A95E06981CE" modified="2014-10-29" version="1">MEERQRGTPRQRAAIDQHSRGTPSHHNAERCRQRGCHRFQRIAASLVLCLALSNHLFPPTVASPFPQSANGAHHSHHHHQHQHHHQQSAQHTPGSGASGPSGHPYSGSSRSSGGSGGSGLGVYMIRSPESTIAPADDEVLFECELNLVPERLDWRFRAQGTPGMRKDYVYIGKNQAGYNVSTVDSRYKLRVSVSAATIGEYQCVAWFGASAIASIPARLTLATIGLEADQPPAAGGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNZ2</accession>
    <name>A0A084VNZ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007902-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF3402 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNZ2"/>
    <dbReference type="STRING" id="74873.A0A084VNZ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007451-RA">
        <property type="protein sequence ID" value="ASIC007451-PA"/>
        <property type="gene ID" value="ASIC007451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007451"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017713"/>
    <dbReference type="OMA" id="HITVESH"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="618" mass="69399" checksum="EDB6B3ACA7E21F5B" modified="2014-10-29" version="1">MLAIYNFNENEMLDGNNALEFPDLDFVYADADSHTNEIAELYSYTELAEFQQNVKGLIKQSSLDEQEQLGLEMEASTAENEEDITDYFRQYEDPINGTGSTNPDETNADNAEEGKDPKNSPPPVVPVEELPQEITNRLPWAPKIRRKDIDLFLNNSRSKFIGYTLKDDHETLAGLPQPIQEGFKTLKKHMYVSLADVQIRREEEITRNPLSTSEGEIQLTPTEILYQAMLPNLSQYMISLLKILLAAAPTSKAKTESINIMADVLPEDMPMTVTQSTKLGIDVSRHKEITVKAVSAILLLYLKHFKINHIYQFEFMSQHLVFANCIPLVLKFFNQDIMSYVGSKNVIPIMDFPSCVIGEQPELTSETMIIGDSAPFSWRNVFSCINLLRILNKLTKWKHSRIMMLVVFKSAPILKRTLKVRHALMQLYVLKLLKMQTKYLGRQWRKSNMKTISAIYAKVRHRLNDDWAFGNDLDARPWDFQAEECALKSGVDRFNNRRYLQVNNGILVGIEGLDYDDPIEGIGVGVGGTIGVGGGVGGDGMNGGGSTVGGGAMCTNGGGVSALGTSDRVNACYGGLARKAEEIELSEEFKQNYEMWLQQEVYNNNIDWDALLSVEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP59</accession>
    <name>A0A084VP59_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome maturation protein SBDS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014978">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP59"/>
    <dbReference type="STRING" id="74873.A0A084VP59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007447-RA">
        <property type="protein sequence ID" value="ASIC007447-PA"/>
        <property type="gene ID" value="ASIC007447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007447"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012741"/>
    <dbReference type="OMA" id="TIISAKC"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="253" mass="28823" checksum="D67AA93F15FC9B37" modified="2014-10-29" version="1">MPKIFTPTNQIRLTNVAVVRMKKGGKRFEIACYKNKVLSWRSGTEKDLDEVLQTVAVFNNVSKGEVAKKEELQKAFGKDDVTEICKEILAKGELQVSEKERQDQLESMFKEIATTVADKCVNPDTKRPYPVSIIEKSMRDIHYSIKPHRNAKQQALDVIKVLKESIPLERAKMRLKVTLPAKEAKRLKDRIGKLSSTVTEGEEWEGERLMLTCLIDPGHFREMDEIIRTETKGAGALEVLNLKEIKEGEEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPA9</accession>
    <name>A0A084VPA9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00007170</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="ATLV01014994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPA9"/>
    <dbReference type="STRING" id="74873.A0A084VPA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007170-RA">
        <property type="protein sequence ID" value="ASIC007170-PA"/>
        <property type="gene ID" value="ASIC007170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007170"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014355"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="27"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="21">
        <location>
            <begin position="567"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="672"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1035"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB39803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129465" checksum="59D37F978F50CF08" modified="2014-10-29" version="1">MKQLPELTNLRPKYKQIPEKQNELLANLGRPHIDSFNYMLREGIEDLLYRLEPLMFEMANQNRIKLSVSDITIAKPSVPISLVEGQERRIFPSECRQKGDLYGGMCTITLNWELDGIKQPSVTREMGRIPIMLRSDACNLSGLSPAELVERGEHADEWGGHFLIGGNEKLVRMLITVRRNYPVAMNRKSWKNRGKDFSTTGVLIRCVREDQLATNNVLHYIQNGTAKLMISIRKSLNFIPIMLLLKSLTNYTDNTIYRKLIAGYEDDQYYKRCIMGMLRDLHAENLHNGQQCRQFLGSLFRIRLGLGFMPKWYSDEQAGDYLLDTCLLFHLHNNQDKFNMLVLMMQKLYVVVQGKAHAESIDSAMMQEVLLGGHIYHLLLRELCISTLSNVRQNLLKLCPDQDSLTVTSHEVMQALKNSSGFQAAMTNFFATGNLARAREMGMTQESGLVIIAENINRMRYMSHFRAVHRGSFFLTMRTTEARQLTPDAWGFICPVHTPDGTPCGLLNHLTSDCTISVTQAPDKVKNIEKHLVLLGMHPIEFVGESALGAALPMREFYSVLLEGKVLGMLPRDNASQVVQKLRMLKIDGVIPTTTEIVFVPARVGGQFPGLFLFVGPARMMRPVKNLTYNRTELIGTFEQVYLDICITPEEAYPNLTTHMELSKTSFLSNLAQLIPMPDCNQSPRNMYQCQMGKQTMGTPCQNWNKQCTAKMYRLQTPAAPLFRPVHYDNMDMDDYAMGTNAIVAVVSYTGYDMEDAMIINKSAEERGFAAGTIYKHEKVELGDDSFFARDPRDASLAISLDNDGMPFQGAELTFGTPFYCYFDVNDHQYHVVKYKSSENGIVDSVKMGSPYDTMRSGKLSYSEVKKQCIITYRIPRNPNVGDKFASRAGQKGICSQKWPAIDLPFTESGMIPDIIFNPHGFPSRMTIAMMIETMAGKTAACHGLVHDATPFRFNEENTAIDYFGRLLESSGYNYYGTERMYSGVDGREMKADIFFGVVHYQRLRHMVSDKWQVRSTGPIDQVTQQPNKGRKRGGGVRFGEMERDGLMSHGAAFLLQDRLFHGSDKVTALVCRRCGTLLGPLDSVTKRLASNSNEFQHLPATCRLCQDDKEIGHVEIPYIFKFLVSQLSSMNINVKLQCSFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPJ2</accession>
    <name>A0A084VPJ2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit g</fullName>
            <shortName evidence="10">ATPase subunit g</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00007263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPJ2"/>
    <dbReference type="STRING" id="74873.A0A084VPJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007263-RA">
        <property type="protein sequence ID" value="ASIC007263-PA"/>
        <property type="gene ID" value="ASIC007263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007263"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011765"/>
    <dbReference type="OMA" id="KSGAWKN"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016702">
        <property type="entry name" value="ATP5MG_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017835">
        <property type="entry name" value="ATP-synth_g_mitoch_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10778" checksum="0F4A7BB1BF7E2950" modified="2014-10-29" version="1">MASVANKGSSLVSALLTQARPKLNVFMKYAKVELTPPGPGDIPAIRDGIARLVSGARTGAWKNLTVREAWLNTLITMEVCFWFYAGEVIGKRHLVGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPQ5</accession>
    <name>A0A084VPQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00007332</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPQ5"/>
    <dbReference type="STRING" id="74873.A0A084VPQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007332-RA">
        <property type="protein sequence ID" value="ASIC007332-PA"/>
        <property type="gene ID" value="ASIC007332"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007332"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023223"/>
    <dbReference type="OMA" id="DRYRYMS"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF61">
        <property type="entry name" value="SD03967P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="87"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007332-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="691" mass="77651" checksum="D9CFBEE08E21E301" modified="2014-10-29" version="1">MASPATTTTTTTTVGPTATTTSGSSGFSCCPANGESSSIDDSIELNDGQEGGNNNTVYHNGLLEKQDYRFPKRPPVDLVFRDIRYDVKRFNISKAKFESKEILHGLNGSFKSGELTAIMGPSGAGKSTLLNIMAGYVSSGVSGMVQVNGKSRSHNSESFRKLSCYIQQHDALRPWLTVNEAMICATHLKLGFGISLDEKRKLIEKILFMLGLEQKGSTPTMGLSGGQKKRLAIALEMISNPPILFLDEPTTGLDSSSCTQCISLLKRLAQDGRTIVCTIHTPSALLFEMFDQLYTVVQGHCFYQGPTNEMLPFLGDLGYHCPSYHNPADFMMEIAVGEYGADVGKIIKAALKKYYEISSRCIDLDSTFDDNVKSIESYSMREKGEEMCTLRKEAESMETSSYEEEDIFSKTKPASLVMQFLLLFYRNLLMTRRNYFLLSCRILAHAVIATVFGYLYTGVGPNANQVLANYVYLYGSMLVMVYTGKMAVVLSFQIEMESLTREHFNRWYKLGPYFLSVLVLEIPVQICCSMIYVVISYHLTGNYVNFERFCVFALFCIAGSICAQSWGFFVGATLSVKLAVFIGPILAVLFSVFGFCTRYVDITPVFKWMWHISYYRASFHGILNSVYGMNREDLHCPETQIYCHFKNPVLFQKDMDIEHVDMQSNMVLIILIIITMYISTTFVLWYKLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPY2</accession>
    <name>A0A084VPY2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Puromycin-sensitive aminopeptidase</fullName>
            <ecNumber evidence="14">3.4.11.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosol alanyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00007484</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.14" evidence="14"/>
    <dbReference type="EMBL" id="ATLV01015079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPY2"/>
    <dbReference type="STRING" id="74873.A0A084VPY2"/>
    <dbReference type="MEROPS" id="M01.A24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007484-RA">
        <property type="protein sequence ID" value="ASIC007484-PA"/>
        <property type="gene ID" value="ASIC007484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007484"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017596"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="23">
        <location>
            <begin position="237"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="21">
        <location>
            <begin position="454"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="22">
        <location>
            <begin position="751"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB40026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122424" checksum="972A0FC8B83A4632" modified="2014-10-29" version="1">MKTPWFDSASVRFAVLGCPGFGPVFRGLLSPVCRLSRISLDSRTSPQAPRPSVSVSSNSVIVNSLGLLRSVVSQLVTTARTITSGCSSESIARFERQRLKCCLPSSVTSPKPTRPAAAAQWKISLREKSTVSSTVSNNAAWRQSPLCTAISVRSNSSSTAFDTVVSVKLSPLQPWPFGARDKEVTVLHRSNDCLLQQRRTITTNSSPASDVSETSESKMSTATGKPEFQRLPNNVLPVHYELSLKPDLTALTFEGTTTVQLKVNTPTDRITLNALDLKILKATVTFGETTLDSQDIQFDAGQETACLVFGKELPVGEASLAVEFTGELNDKMKGFYRSKYFTASGEERYAGVTQFEATDARRCFPCWDEPALKATFDITLTVPKDRVALSNMPVREESVGGDGLRVLRFDRTPIMSTYLVAVVVGEYDYVEDKSADGVLVRVYTPVGKKEQGRFALDVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLITYRETFVLVDPENTSLIRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVDHLFPGYDIWTQFVTDMYTHALELDCLRNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHHYIGDEDFKRGMHVYLTRHQYRNTSTEDLWQALQEASSKPVGAVMSTWIKQMGFPVVRVLSSTDLPGNKRLLKIAQEKFCADGCQPSEPCRWMIPVNVSTPKSANAVSTVLEADTADITVEGVGPDDWVKVNPGTIGYYRTQYPAEMLDQFLPAIKDQSLPPLDRLGLIDDLFALVQAGKSSTVDALKVIEAYRNESNYTVWASITNCLAKLQLLLAHTPVAEEFNAYGVRLYRPVAEKLGWDVKPDESHLDTLLRSLVLGRLVSFRCPKTVAEAKRRFAEHAQNKSVLPADLRSTCYKAVLQNGDLETYNEMLRLYRATDLHEEKDRISRALGSIGNVDILRKVIEFAMSEEVRAQDSVFVIVSVAMNPKGRDMTWEYFRERWQVLLNQYEGGFLLARLIKYLTENFSTEERALEVEQFFREHEFPGTERTVSQSIETIRLNADWLRRDLDAIQAYLKQQQQQQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ27</accession>
    <name>A0A084VQ27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007533</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007533-RA">
        <property type="protein sequence ID" value="ASIC007533-PA"/>
        <property type="gene ID" value="ASIC007533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007533"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007533-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="17512" checksum="62E25AA183646F72" modified="2014-10-29" version="1">MSFISARAPPTTAASKARVPNELTGYAADAETHRTRMSHMALFGEFSSTTNGIPRGRMFPVGITHTPSSPVEIRTDRLVKETDGIAWRTAWKASEECCTAAAAAATMPWWKFARNGKWPRSVRKKLKNKINPASLCAAGCKQMENETLQGISEIEERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSM0</accession>
    <name>A0A084VSM0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525056">
        <property type="protein sequence ID" value="KFB40964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008511-RA">
        <property type="protein sequence ID" value="ASIC008511-PA"/>
        <property type="gene ID" value="ASIC008511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008511"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004508"/>
    <dbReference type="OMA" id="KCCCCAS"/>
    <dbReference type="OrthoDB" id="8190053at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053077">
        <property type="entry name" value="MARVEL_domain_protein_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34609:SF17">
        <property type="entry name" value="GEO08273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18801" checksum="75E9390463901FF7" modified="2014-10-29" version="1">MAQPMVNSCCRCFSLRSGSIASGILGIILSIISIILIFTVRIDFKTILMDWLPQNVVKIIYALNLVMTILISLLMIMGVVKKNHYFMMPWVVLGLMLAIGLLISVIYNAVVYYIDGFVLGGTLWLVVGLLTVVIYVYMWIVVYSFFVTVKNENDRGRYSKQPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT73</accession>
    <name>A0A084VT73_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lateral signaling target protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00008728</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of epidermal growth factor receptor (EGFR) signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lst-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016263">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT73"/>
    <dbReference type="STRING" id="74873.A0A084VT73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008728-RA">
        <property type="protein sequence ID" value="ASIC008728-PA"/>
        <property type="gene ID" value="ASIC008728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008728"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006071"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15733">
        <property type="entry name" value="FYVE_MTMR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000073">
        <property type="entry name" value="myotubularin-related protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046978">
        <property type="entry name" value="MTMR4_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="257"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="408" mass="45199" checksum="72B46842EE059DA9" modified="2014-10-29" version="1">MTHQNQQQHQWESDKESLECLEVPCTSLLIFSDEEEDEKEHEFPGADGECTPTLDEQQLREEIRKHQRLFTHTARVCRTVRRFLERTKQKKNGPIGEDLFARDFHRYTRFPRETPMIRDPLGSATEEMVLDGTFLKRYFSESSEEEDDDDDEDGSVFGGRTQMLRRMEETRARTFSWGRGSSDGGGGGGGGGGSGHKIDADVSFPHQLMIDSMNENASNCSWEAVDDRSAPSSGANSSQQMQYSSGVGSSSVLWVPDHAVTRCTTCQTEFWLGLRKHHCRSCGQIFCANCSEHSAHLPDERLYQPVRLCGPCYQRISSTVAPAANSNTTTTTSSCAPGNIANGSASFYRATSNSSASNLSRSAGNNHPSVHSMMTEWKHEGNTLRGSSEPPRVNESCCKQNVTAAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTH1</accession>
    <name>A0A084VTH1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">HMG (High mobility group) box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008856</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008856-RA">
        <property type="protein sequence ID" value="ASIC008856-PA"/>
        <property type="gene ID" value="ASIC008856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008856"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="19317" checksum="8835F499821920FC" modified="2014-10-29" version="1">MENSDVLMFHCHWLIDKQHRPNWNGNHSALVGNRKRAHPQGGRLSENTGGKPNLSDEGSSVGANASATWRGNPHPKPRATRAKRVQPKRQQGVELESGQHETHFRRLALRGAASGCRLYGKERGRKNSMGCLEMAGMSDDARRTIRPQRPKSEKRKDEMNLWGHAMFHNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTQ9</accession>
    <name>A0A084VTQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008964</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525091">
        <property type="protein sequence ID" value="KFB41353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008964-RA">
        <property type="protein sequence ID" value="ASIC008964-PA"/>
        <property type="gene ID" value="ASIC008964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008964"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008964-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10699" checksum="BF2338AB68B6E0A6" modified="2014-10-29" version="1">MSDIAVVVSVCKSGNRRRSSPCQVLRTDKKRVSGIGWLKSETRYSYPMPYIGVEPAAPPVGDRPNPVAKRGNGRWLATSVDDSVVLVRLQASLSWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU92</accession>
    <name>A0A084VU92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004823-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU92"/>
    <dbReference type="STRING" id="74873.A0A084VU92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009133-RA">
        <property type="protein sequence ID" value="ASIC009133-PA"/>
        <property type="gene ID" value="ASIC009133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009133"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011515"/>
    <dbReference type="OMA" id="TLCEACY"/>
    <dbReference type="OrthoDB" id="10038884at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF7">
        <property type="entry name" value="PROTEIN SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="583" mass="61367" checksum="7615B990EF91FF75" modified="2014-10-29" version="1">MERRNGGTSLAPPRPPKSLPRHQHQPPPPHHHHRPVTPPPAPHLHSHNHPHQQSNRSIGSNSSTLSSVSSSSSTAALLRPQIAPLVPLHSSHRSRSPPPPPLPPHHAASRPTSPAPPAGSTFTRRARLSPVTTHTATTTTVAAPLHLHPSPAPPPLLLLPVDQPAIVAPSSNPTTPVTLAAPRPENERLANEYVDTPASPLLSTRVVGTTPTGQPRPTTRGGDLVDTGLPTPMETKAHPTRTTTTPDAIIPVSRPATAANAVSAAAVITKQPLASGKKSAKEGSDRHELLELELQAHHHHYLHGGRHTQLVATVGGGGGGALIGGSPTGADGLTGVGSITCPRCRKCRCEECLRPRPLPTRWICDKSCLCSAETVTDYASCLCCVKALYYHCSKDHELEREVDGPDGAPETDTISCADDPCSCVPHRRTTRWACLGALSLVLPCLWCYWPMKGCVALCATCYAKHSRHGCRCAQAPQSLSSSAAASPLAGGITNASMLLGTGTGAGGGSGALMRSPTAADAIDGEHGRSAKGDPALDSELHLHHHLHHHLHHHHHHHHHAGGRGAVTASTPEKRLLDMSPDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUS8</accession>
    <name>A0A084VUS8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">N-acylneuraminate cytidylyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009353</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017009">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525142">
        <property type="protein sequence ID" value="KFB41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009353-RA">
        <property type="protein sequence ID" value="ASIC009353-PA"/>
        <property type="gene ID" value="ASIC009353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009353"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="17427" checksum="027347414660B0E1" modified="2014-10-29" version="1">MHHPLVIDLSFRGSEILENPGKVDGRTDALFAISERVPQSRGFILLGPVGRCSGLVRSLSETIGRTGDLILSSPNHRVSVLRASIKSRREGLNSLVIDFVASRKVKGSVDGKRRSVPGRDKGKKENLEPSSSLTSRPPCSVLRDGFFPEKPKPDEVDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV79</accession>
    <name>A0A084VV79_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000382-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009718</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009718-RA">
        <property type="protein sequence ID" value="ASIC009718-PA"/>
        <property type="gene ID" value="ASIC009718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009718"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9394" checksum="B739E91B7A36F973" modified="2014-10-29" version="1">MPLPLSTTRPLLPMPPRLSTTRPLLTTPPRLSTTLPTPPIVKAAYPAAYPAAYPAYPAASLAYKAPLAAPVAAVHGGSVVQFAGLGASYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV85</accession>
    <name>A0A084VV85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000383-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009725-RA">
        <property type="protein sequence ID" value="ASIC009725-PA"/>
        <property type="gene ID" value="ASIC009725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009725"/>
    <dbReference type="OrthoDB" id="5975336at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="9735" checksum="A04C1C43BF248EAE" modified="2014-10-29" version="1">MEGKEGFRFRNINDFITRLSTGCQAGGGGGTGGSTNPASTTSASASATLGGSSRTYDLYDAEADVNREKRTQRHLGAMASSQVLCVCPLMILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVE8</accession>
    <name>A0A084VVE8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013084-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009506</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017174">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009506-RA">
        <property type="protein sequence ID" value="ASIC009506-PA"/>
        <property type="gene ID" value="ASIC009506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009506"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009499"/>
    <dbReference type="OMA" id="FIQIPTP"/>
    <dbReference type="OrthoDB" id="8197466at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="21111" checksum="9F7E0A2287F82320" modified="2014-10-29" version="1">MADAGPKRMAAAGKIPIVSWIPCHSYFFIPNFFSSPSDAIGEDVYRAKRKFRPEEWAAANAILDLLAQLKSARQGQLTTQAARRITTTTTTTTTTTTTTTARPIVQVKARADRSPREDEDVPQFNPDGTIMLQLPGKLFGNATNFVLAAAKLFGDFITNTAIRTARFMQLFQPIAGRHLYIQIPTPSPPGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVW3</accession>
    <name>A0A084VVW3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017315">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017316">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017317">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVW3"/>
    <dbReference type="STRING" id="74873.A0A084VVW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009768-RA">
        <property type="protein sequence ID" value="ASIC009768-PA"/>
        <property type="gene ID" value="ASIC009768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009768"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000512"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007565"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017157"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018511"/>
    <dbReference type="OMA" id="FAAHINI"/>
    <dbReference type="OrthoDB" id="10055806at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784111" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123015" checksum="B1CF70F40E11D52C" modified="2014-10-29" version="1">MSQIVHCFLRFCFTVSTVTVEAVLGKTATLPCDIEPEELNDRVYMVLWFRESAGKPLYSYDVRGRQFSKALYWSETSAFGPRAYFVTISKPAALSVDNIQLDDEGVYRCRVDFQNSPTRNHRINLTVTVPPHQILVYDASGLDVTGAIGPLQEDDNLVLTCEVRGGRPEPTVTWLNGNEIMQTGGGVSMGRHVTVNRLEIPKMTRSALNNTYKCQASNTKLVPPAERSIRVDMLLKPLSTALSSKPKQLIADQEYVLACNVEGSVPETDIKWMQNNRPYMKGKIKTINNSSMVSSVLSFRPHPDDDGTILKCEGSNPRLQNSALEDSVIMNVLCNIMIVGASLDETVPVPCHVAADPLDVSFDWNFSNSGERFEVASGQFNLLQEFHSTEGITQSRYDADEDNSETIYELLYTPKSEREYGTLACWAKNSIGKQKEPCLFQVVPAAEPSPLRNCTLRPYSTLLPPGNHGPHGTQNTTSAASAGSAYSYYAGEPSGTRAGQHYRDTNYVGPQFVKDRNVPSANGTTTSTSTSTGRRNVTKFNQKNPSSALGRRTSNRTAGGGGGFSPGRDSDLARLTADEELGTVEGHASGSKQIPPLVPEQQRRRASGKITPGSRSSASSSSSNSEERNSRMNLLNTATAVLLGEGGSAAVLASSATGDDPAGQQRGNRLRRYAASDGARNDSLPGSVRPDVGSNQRDRPMEEGQRPRRGGNNYRTTAASTAPPPIASQLKSKAIRYQSGPSPYSSGSYSTGWAHHDGAGVRRRVRRWSAAALFLEAYDSRTRKLRLNITSALNDVPLFRIDLTDDTDGFAILPIAALLTGALFTIGIAVLLVVVLAIRRKRDGHGTGLCDGKEKHIGMDITVTTPLEMGMGQQKYVVAYTLKQGVEKQPDILSAQKTGSASVQSIKDMGGGKPGGAIYATQGYDPPQQKSTPSSRQSTLKRTADTANSYSLLQQQQQQPTGTASKYSTELLEYEKPYPNYQPTLQYNHNPPPLVDPYAYKSSPLGDTGTTGYRLTGGMGGGGEYQQSQGVELSSGNPLDYRNASHSSSSSNLKQSCLNSASSSGTPSTGTATSGTVGRMGGTTGNPEYRYSGSEFVTDLLDFGSAPSPSSGSSNVGATLTKNRNRQHIITDTLPGPESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWC2</accession>
    <name>A0A084VWC2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009946</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017552">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWC2"/>
    <dbReference type="STRING" id="74873.A0A084VWC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009946-RA">
        <property type="protein sequence ID" value="ASIC009946-PA"/>
        <property type="gene ID" value="ASIC009946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009946"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="150" mass="17628" checksum="599A08A3F8A8EA7B" modified="2014-10-29" version="1">MGSPAKLQDLPPKGGYQNIPFARVPAKTYFKGWQMIAGYAGISTVGLFLYWLNVKENHRNEIEMRSARNVIYPLLLAERDREYLKQLRRNRDEEAELMKNVEGWEVGTWYGEPVFKTLPKDKLIEPTFQEFYVHTDYKHMANRADVKLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWQ1</accession>
    <name>A0A084VWQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010089</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010089-RA">
        <property type="protein sequence ID" value="ASIC010089-PA"/>
        <property type="gene ID" value="ASIC010089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010089"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14300" checksum="B033B41B80C90001" modified="2014-10-29" version="1">MLNREHTARDGPQGSFWGRRSFGGLRWGLSSGCLPFPNSSASLADGAVDDRESLGPMDVEFGRRRNSSYLWERSPSSNGRSACRGSPDRSNPSKWSIKSPEQIEATAAERLCENVSRSWPPLGKDIKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXD4</accession>
    <name>A0A084VXD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP011297-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010355</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017988">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525205">
        <property type="protein sequence ID" value="KFB42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXD4"/>
    <dbReference type="STRING" id="74873.A0A084VXD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010355-RA">
        <property type="protein sequence ID" value="ASIC010355-PA"/>
        <property type="gene ID" value="ASIC010355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010355"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024474"/>
    <dbReference type="OMA" id="HREAHYP"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000149">
        <property type="entry name" value="serine/threonine-protein kinase unc-51 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10219" checksum="0632D6F7C8632671" modified="2014-10-29" version="1">MEIVGSFEYNSKELIGHGAFAVVFKGRHREQHYPVAIKSITKKSLAKSQSLLGKEIKILQELSALKHKNVVKLLACTEKDHNVFLVMEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXH9</accession>
    <name>A0A084VXH9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00010407</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01018074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXH9"/>
    <dbReference type="STRING" id="74873.A0A084VXH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010407-RA">
        <property type="protein sequence ID" value="ASIC010407-PA"/>
        <property type="gene ID" value="ASIC010407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010407"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004887"/>
    <dbReference type="OMA" id="CITINYM"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000007">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11489" checksum="1BE7ECF040CEC376" modified="2014-10-29" version="1">MPNIKVFSGSSHPDLASRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXW3</accession>
    <name>A0A084VXW3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="7">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ZHAS_00010558</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="25">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01018208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXW3"/>
    <dbReference type="STRING" id="74873.A0A084VXW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010558-RA">
        <property type="protein sequence ID" value="ASIC010558-PA"/>
        <property type="gene ID" value="ASIC010558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010558"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022189"/>
    <dbReference type="OMA" id="HMEHVEA"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <sequence length="344" mass="37176" checksum="E3CD77000E047AA9" modified="2014-10-29" version="1">MLAKFRGTLLGALVGDCCGAPFEGQLMDSGSKLILRKNLDKLEGPAFKAPYKKYTDDTAMTLQVTKTLLDPNGFSQKLLAKNFVVEFFKESNRGYGAAIGEVFRKLRLTKVSDPTGPAMAQFNGSGSYGNGAAMRVSPVALYCVNKSVSELVKLVTDTATVTHTNVLGVNGAILQALAIRQSLLLKPDEPFCWKAYLEALKKDIAEVEKENDPDLDANPNAYEMQLKNMEKLLDNTVEASDENVLNLLGHSVAALYSVPTAIYCFLRHTKATAEDPTGKPFRNTLEYAISLGGDCDTIGSMACAISGAYYGDSVISPALLKHCESADNISSLAEQLYKVVESKS</sequence>
</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
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                <person name="Lv Y."/>
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</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010859-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15511" checksum="A7509A3A5145167B" modified="2014-10-29" version="1">MKPNGLSATVNRARNDTQQDRDDGGGGGGGGDAWRCHFTTANNATRSSSTTNSTVKHYMSWRTDGDGAEEDSTDDDDDDEDLHNNNNNGYCNNKLINNYKTTDNNNGNEYTLSNGNDINPCNNNQLLMRAFLQHNASGRHH</sequence>
</entry>
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    <accession>A0A084W013</accession>
    <name>A0A084W013_ANOSI</name>
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        <submittedName>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019068">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W013"/>
    <dbReference type="STRING" id="74873.A0A084W013"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011371-RA">
        <property type="protein sequence ID" value="ASIC011371-PA"/>
        <property type="gene ID" value="ASIC011371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011371"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012511"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019569"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="431"/>
        </location>
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            <begin position="536"/>
            <end position="598"/>
        </location>
    </feature>
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            <begin position="26"/>
            <end position="41"/>
        </location>
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            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="598" mass="60728" checksum="81340CAFCB78899A" modified="2014-10-29" version="1">MAAPSPKSALRKESGRPPRKKKKDSSSPMPSTSLNLTSAPATATTLPAALAQMLPSAAASNTTTTTNTTTNNNNTTLTSLPSAVTGGAAVAAAVAGVAGGVSQHHPQANVLNPTSLANQQQQPQQAHMQQASQQPIIAPLPPQSSSSSSSSSSSSSSSSTSSSSSNATTGSTLTTTMVGGGGILGSGVSTNNTSSSIAAVSSGYGVGGVATGNGSSGGMLQHPPTSTGSREQWVDHQYARSAGFLAASDEFGRNEQPGQYGRWHTLNSFEQSIKSEGLGMNLLNDIPAALKQDLTASIQQGLLPQLTTNMDLCMAHLQNMQQQQSSNGFVNEFNGNGPLNGGMGIAGMNQMVMNSMASTTNSLMSNVNVMSSIFDPLQSFIRPGGGGGGGSGAYHQPNAGIGAGGAGVNPPTSGSSNNGGGGLTGGNNPSAAMHLERSIDLTQAASGNNSGAMGAAGMMAGGGNGGGSAMSIKKEEPGGAGGGKFMLTPKPIEDLLINPNEKKMGTTPPPADAKGNFVHAFNKGHDQNLKNAWSSLASAGSPQNTPTSNKPKPAMDSFQAFRNKAKAKEEQKRSQAEKEMKRQLEQQKIKQEEMNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E1</accession>
    <name>A0A084W0E1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glypican-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011413</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011413-RA">
        <property type="protein sequence ID" value="ASIC011413-PA"/>
        <property type="gene ID" value="ASIC011413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011413"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="16192" checksum="0CD95C7BAB6A6D21" modified="2014-10-29" version="1">MQRFIFGATKQKSPFWRTQHTSRSLTPEVVKPTVKVEENGQPGDGESIAVATARSCDLFSARTRSSDDRVTRRSDVHHVIDHASPVAALAAPLEKRTPTINRANRLQLINKREERLRNPNSSNGMKKTNPGMIFPAMLVSVCNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0K0</accession>
    <name>A0A084W0K0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone deacetylase</fullName>
            <ecNumber evidence="15">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00011479</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="15"/>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0K0"/>
    <dbReference type="STRING" id="74873.A0A084W0K0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011479-RA">
        <property type="protein sequence ID" value="ASIC011479-PA"/>
        <property type="gene ID" value="ASIC011479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011479"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014532"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10005">
        <property type="entry name" value="HDAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000004">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="20">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB43744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="432" mass="49083" checksum="822890D13B13DF21" modified="2014-10-29" version="1">MGTKKVSYFFNPDVGNFHYGPGHPMKPHRLSVIHHLVMNYGLHKKMQIYRPYKASAQDMCRFHSDEYIEFLQRVTPQNIQGYTKCLSVFNVGDDCPVFDGLFEFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYVQVFKPVISAVMEFYQPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKDLNVPTLVVGGGGYTLRNVARCWTYETSLLIDETISNELPMNDYLEFFAPDFTLHPDIPSRQDNANSKQYLEAITRHVYDNLKMCQHAPSVQMFDIPEDALPEELKVKTEEPNPDVRMSQDDEDKLVEPKNEFFDGDNDNDKSENEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2B6</accession>
    <name>A0A084W2B6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Dihydrodiol dehydrogenase 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012300</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2B6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012300-RA">
        <property type="protein sequence ID" value="ASIC012300-PA"/>
        <property type="gene ID" value="ASIC012300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012300"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012300-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12776" checksum="3EEFBF94247FF7FD" modified="2014-10-29" version="1">MCIRRGPLQKLLSANAFALSRAFRHHSGQHCRLQRVGWAIAIDRRDGTNRKASLIAIPRPASGERALKADKVRTTCAIRMSVLQDLAAVETFDKQALTKAIGISWVLSSLHNQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2J5</accession>
    <name>A0A084W2J5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00012224</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="ATLV01019621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2J5"/>
    <dbReference type="STRING" id="74873.A0A084W2J5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012224-RA">
        <property type="protein sequence ID" value="ASIC012224-PA"/>
        <property type="gene ID" value="ASIC012224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012224"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007164"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="505"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="601" mass="67574" checksum="987193C0CEEDE1BF" modified="2014-10-29" version="1">MNYILMTEDNNVTIPLLESDDLWMNELFNKSCDTVVLVTGWTSNVNEPNRAIDTIYNAYKARGGYNFVVIDTAEYVDTLYTWSAFNTNDLGKGLADGLKGLIKYVPLERIHLIGSHKRAWELYAETVYPENEKSLLAVKCNSLLSLKTGGCIGNPIPLGFAFAPQNNDHLSKRWNHLRKILERSGPFCHPNFAASSETLEFLLNTCKILVIGAGGLGCELLKDLALMGFRDIHVIDMDTIELSNLNRQFLFRRTDIGKSKAQCAASFINNRVPGCVVTPHFCKIQDFDSSFYRQFHIIVCGLDSIVARRWINGMLISMVEYEEDGSVRNLHHSVDRRRNRRVQRERPCDSTRNDGLHRLYVNYPLCTIANTPRMPEHCIEYVKIIQWPKETPFGSEVALDGDDPQHVTWVYEKAQERADSFNITGLSYRLVQGVLKNIIPAVASTNAVIAASCATEVFKIASSCCEPLNNYMVFNDVDGIYTYTYEAEKRSDCLACSQVPRSVEITDPNTMTLQDLIQHLCDNPEFQMKSPGLTALLEGKNKTLYMGTVKSIEEATKGNLTLSLTELGLKDGQEVMVADVTTPNTILIKLKILPTEVEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M9</accession>
    <name>A0A084W4M9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013132</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013132-RA">
        <property type="protein sequence ID" value="ASIC013132-PA"/>
        <property type="gene ID" value="ASIC013132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013132"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10276" checksum="730FCCD569F04738" modified="2014-10-29" version="1">MSRSIWMQHDDLAAKPNRVALQLQQNREPSDFLLAHATRVEEWLRPAIAIASTPLSCFRVCFDYLAAVASEGSCLDLFHFASRATLPAQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4V3</accession>
    <name>A0A084W4V3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008271-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00013084</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4V3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013084-RA">
        <property type="protein sequence ID" value="ASIC013084-PA"/>
        <property type="gene ID" value="ASIC013084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013084"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015548"/>
    <dbReference type="OMA" id="YPIGRTY"/>
    <dbReference type="OrthoDB" id="6160832at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="247" mass="28027" checksum="5E439B968FF7A71F" modified="2014-10-29" version="1">MLCVFESCSTNKQSRRKNIKDGVQFIPFPTTDYSNEELRRLAKKRLHWWCRIAGVDYTDTLLNQLHVCSLHFVKGTAAQLWDTFSPDWIPTLSIPVGTVNRLHPLPGESCDDFIKSEQHSEETIANPLLDETPDPIALRTELIDELIAYPIGRTYHLLNDESETASATPYDVKNLANTLKGCLTRTSNVGRMVFETNAPHVPERMFSGNSSITSVDLSTEPRWETERNIMKLQNSVLGLIAMFDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5M1</accession>
    <name>A0A084W5M1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01020673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5M1"/>
    <dbReference type="STRING" id="74873.A0A084W5M1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013457-RA">
        <property type="protein sequence ID" value="ASIC013457-PA"/>
        <property type="gene ID" value="ASIC013457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013457"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016911"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.430.10:FF:000002">
        <property type="entry name" value="Dihydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="185" mass="21303" checksum="389F6433E422ABE9" modified="2014-10-29" version="1">MSKFSCIVAACENRGIGINGDLPWKLKHELKYFSRMTKKVRDADKRNAVIMGRKTYFGVPETKRPLPERLNIVLTRNSASYTFPSDVLVCKSLQEALHKLDTTDYGKDIENIWIVGGGSVYKEAMESARCHRVYLTEIKKHFECDAFFPEIPKSFAIVANDEDVPSEVQEENGIQYEYKIYEQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W678</accession>
    <name>A0A084W678_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein C14orf166B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020754">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W678"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013730-RA">
        <property type="protein sequence ID" value="ASIC013730-PA"/>
        <property type="gene ID" value="ASIC013730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013730"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9414" checksum="ABF7152ECE55C98C" modified="2014-10-29" version="1">MSEICGIPLWPPTRGDWVRGVFRAKGGKRFRSFLALRIHRLPAGGGGDGGSQGDSQKCGPKSVRLWYSVGHPFYIDIFFSTTTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6A5</accession>
    <name>A0A084W6A5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich venom protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020766">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6A5"/>
    <dbReference type="STRING" id="74873.A0A084W6A5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013722-RA">
        <property type="protein sequence ID" value="ASIC013722-PA"/>
        <property type="gene ID" value="ASIC013722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013722"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759966" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9325" checksum="1063405CD3FD4171" modified="2014-10-29" version="1">MHKFTVLAVALLVLVLHVHAQTERRECTGRRETYQECNNSCKEPKCNGPANPTCPDVCIPGCYCRPGTLRNKKNVCVPPSKCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6W0</accession>
    <name>A0A084W6W0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP004320-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013937</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W6W0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013937-RA">
        <property type="protein sequence ID" value="ASIC013937-PA"/>
        <property type="gene ID" value="ASIC013937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013937"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017209"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="10">
        <location>
            <begin position="480"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1742"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1802"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1980"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1744"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1812"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1834"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1861"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1877"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1980"/>
            <end position="1992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2018" mass="229656" checksum="23D8002B8E75ACC6" modified="2014-10-29" version="1">MPDGVNSEKKPGDDIWGERCVLNKQRRSFVAKANYSAPNKQHHIDVDVGDTVVIEQESSHWYYGHNCYSGERGVFPKAYVHRVDSKTSRDGDLVIQRSEIVEEITTVLREWQFLYRQLYLSTHPSFKRIQSKMLELIRLRSQLLSGNLPVDEMKNIKLKATSEIDTGNKILNLDMVVRDESGNILDIERTSTTQLYEHHLNAVDRIKRANTSTNKSRNPDIVNRHSHNLLLSVHNFVCRLSEDTEILFTLYDGDEMRAITENYVVRWSRQGMAADLDQFNNIKVLFTDLSGNDLSRNRIYLVAYVVRIGAMDGKDTDLRRSSMANSTGAGSYRSHKNHLTQQMSTPSSPGPGGGGGSGTPSSTSLSSIGGANEYHMRRPFGVATLDLRPIIKRSEDFKSDTQLKMPFIPCEKEPLETTLRKLITNKDLGEKSDAAIWISVDILYGDIKQVRDEYPHLVLGNVAFARKMGFPEVIFPGDVRNDLYLTLVSGEFSKGSKTSDKNIEVTAYVCNRQGVAIPGVISNGGGGGPLNEYKSVIYYHEDRPKWSETFKIDVPIEEFKQCHLRFTFKHRSSNEAKDRSEKPFAMAYVRLMNDDGTTLQHSRHTLLVYKIDHKKYDEETQYNYLSLPSLADDLPTGGSKPSIAGFSLASKDSFIIATNLCSTKLTQNGEDGGIAERADELRCEEVVKFLQDILDALFNILVSNDDPDKYDNLVFKCLLRLIEIVYDLKYQHFQSVLDLYINESFSATLAYEKLINVVQTHIRNAINNIAKDRVTSNIYHQPNDNDEALYRTTKYLQYIMKFIIRSRLLFANLNHDKDRELFEASLEELLNSFSELIKYQNDLLKSQGALLKYLHIIASDLMEVYDPVKLSQKIVDIIMSVPTGRLNQSKMTCIKDVVDSKLFKLPQCRAILLPVFCRQIKDKLESKEEGDFMCDIRQHEKNLTKAARVLGESKSQLHTRENTAKTKVSECVNIMNNMLELLFHSEEDIGSVDNDVRDIMLILLRTVIQSSIAMDRSNPLVGNLVAIMLGIFRSMTEAHYQCYVRSFLTTFDLLDFLTEILLVFQELVSKPVFPVDWLDMIMHQNTVILGSLRHFAAIIMDQFFSPFEWQVWSNYFQCSITFLTQPALQLNQFSKTKQSVIRANYRDIRRETVFEIRKMWFNLGEHKIMFVPRLVGPILEMSMIPEEDLRRATIPIFFDMMQCEYYSSRYATESYGDTKRNTAHIKGNFNNFEKEIIEKLDHFIEGGYGDAEYKDLFFEIMHESCSNHSTLQTHGVQCVQVLTQLMEKLLEYRCLIHDESKENRMACTVSLLQFYSDVNRKEMYIRYVDKLYELHMEFDNFTEAAYTLKLHSNELCWDETPLSMLLKSKRHYLACQTHRTLKEQLYRSMIDLFDKGKMWECAIDLCKELAQQYENEVYDYLSLAELYKKMSQFYENILRTTRYESIYYRVTFFGAGFPEFLRNRAFVYRGNEYEDAGSFNMRILSQHPRAELLTTLTPGPEIQQCEGQFVQIVKVDPVSRDIRFGGKNTQTIAANIVKFYKSNNVSEFQFCRPIRENGVGGDDIAGTSYERTIMRTTDPLPGILRWFPVKSTETVMISPIEMAIETVDAKNRAIRELVLEHQNDPRIPVHSLSAVIKGVVDAAINGGLPIYEDAFLTPEYLDKHPGDDHLVARLKDLIASQIPLLEVALLLHKMKTPAILLPFHEQLERCFATIQANVEAKYGKRVTDIKIDRDAEVTLRRHISTNQPQISMDSSRLSETSIGSSDSGISKNQNSRPTTTSSGGFKNTIANLANFNTVNLARTSLGTSPGSKTKKDKTLTKRRSSRKLHPKRPLRSEVEKEKRLSRPPSIATPTMSNKSMAGATNANGGTLAGDTHSIGSAESSSNRNSIITNGSTTSEEDSTVPPPLPLKTRNDADYSNIAGKGATTVLNLTDQQQRHQFQSSYSISSPQASNASHYITFKTDHDSRGDHRVILINSSSVSSTVCSPGGCSSPPPGAYDDRKRPPTPPPKPARNSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W761</accession>
    <name>A0A084W761_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP002642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014031</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W761"/>
    <dbReference type="STRING" id="74873.A0A084W761"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014031-RA">
        <property type="protein sequence ID" value="ASIC014031-PA"/>
        <property type="gene ID" value="ASIC014031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014031"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001808"/>
    <dbReference type="OMA" id="HYFVQDC"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="796" mass="89385" checksum="83231537F6E6CF62" modified="2014-10-29" version="1">MELGDSNSSVSSGPDKILSLCWNAGALGASYYDIDQLELFAIQQAIEPRPQYALLRELVRRYNPLFYVLSGASCFLDDCTELLGLPPRTTTGAPDSSRASESTATNVKIYEFHAKAQATAKNRLLALKVSGMPLESDERECRTFLESMLPFEQELLVHSVGNLLLLLDSAGDMVPTERLVTKVNLTTPSTQLIIDGLTYEALQIFDASRHPSGFKCGTDTRGLSVYSLFNRCSSKNGEEWLSRLMTQPIRDSSELKRRHDTVQWLLENVRYGNQFDLCLKHLSNVGLLYRKILQATARNREWKMLKKNLYYLYSLCKVCTMALEVPATAGTLVEDLGRYSRNPDNALKHVLYTVDKCLDLEKGEEENKVVIRAGLDPEIDQLRDQYDGLRRLVLETSRLEMENLQLDMGHVCVTYLPSFGFVISTQIDDQLQRSGIFNNASFDLVFQADQTAYFQINLCKELNTEFGQLIGRMIEQELALLTRLTTYVGHKFPEIMDVFKLAGKLDALISFATVAKMHRYVRPIISEGKSLVVQAGRHVLLEHQKTYRPNDTNIGETNHHYVSVLAADTSLGKTTYLKELAIICYLAHVGSFVPATHAQIPILDSIYTRLDHPESIFSGKSSFMSELYQMSNVLQHASSKSLVMIDEFGKGTNYVEGKSLLVASVEHLLKRGIHAPLTFVTTKFTGIEEFLPRSHQFLSLKIHREAQGNSRDGCNDSTMNMTAADPDDPSEALKTSYQLASRAVAFAMIKYHQSCGQSPGTETVRLLMDGTPITRVAERCLEISHPPSDHPRQRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W870</accession>
    <name>A0A084W870_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014412</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W870"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014412-RA">
        <property type="protein sequence ID" value="ASIC014412-PA"/>
        <property type="gene ID" value="ASIC014412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014412"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005679"/>
    <dbReference type="OMA" id="ACFTTIA"/>
    <dbReference type="OrthoDB" id="7742345at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014412-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="509" mass="54035" checksum="06DC9A19AD50518A" modified="2014-10-29" version="1">MKAFCFSLAFLCLVQTILALPRPDFGINGDVGNSDKVDAGALSLNGEFVLTGQKDITLTAGYTLLATLRTKLIDIGDAIVLKGTAFATQLKTLSTDDTGPYTPAFGLVETKLNELETLFRTGLAADITAIVTPLGRNSIKLQFEDAFADVLTIIGTLRTSLTTLKTDVGKAQRAAGTSATVSTAIIRKNIPAKSVTDVVTNVRTLRANVQLVTFIINSSLENIALADEFVVEITADAEENVDLYDDSVSAFQTFLTVDEAATLTAEVDDNEPETVAELLTEIDADLTAAAGYSSSTLQAELTSFGDALVNGLSSAKTSFGTSLTTYSNKVPNYITDLNVGFGNALCLPIKTVSVALAANAPYSDFCFSKYSPRVVALLGLTISAFDMCFQREVDKFATLEAIVAGIVVQLAYNFEDLYGNLAECLLLDDPDLTSCFTTITPYYVVLTAQITEHTTTLEELVDAETVASSNRLGACIISSLYVTIAQGYEISTDVTTCMTSGPQAPASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8P3</accession>
    <name>A0A084W8P3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tox-SGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014626</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W8P3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014626-RA">
        <property type="protein sequence ID" value="ASIC014626-PA"/>
        <property type="gene ID" value="ASIC014626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014626"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021871"/>
    <dbReference type="OMA" id="ANGNHKH"/>
    <dbReference type="OrthoDB" id="5426877at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050708">
        <property type="entry name" value="T6SS_VgrG/RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028901">
        <property type="entry name" value="Tox-SGS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305:SF15">
        <property type="entry name" value="PROTEIN RHSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15651">
        <property type="entry name" value="Tox-SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2761"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2798"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2822"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2903"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2941"/>
            <end position="2962"/>
        </location>
    </feature>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="5">
        <location>
            <begin position="2637"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="domain" description="Tox-SGS" evidence="4">
        <location>
            <begin position="3185"/>
            <end position="3259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3140"/>
            <end position="3165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3146"/>
            <end position="3157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3406" mass="388735" checksum="69A180B0BDAB72CE" modified="2014-10-29" version="1">MAETPADLHYKLQLPVKLLIEADPHDVVEVKQGKDTKRTLFIRKNRLLLIYNRAAVSEDWTESHRVPDFFSVREVNPNYPWAVYDGGLIVLRTVRGLEVHKWSDQKLTRQFVESKYNDAFGYGVATNTFLFGKIYPSEEYLGIITRVASHVQFRSIALTQSDFKLKALKQDPTLSATWTNNTNIISLIDNVANDGQLSITLRTASELQLFRFDEQYSLKELTTVHEFPPLDSEYDRILFAKFNSTQCNDLLHFSTEGLTMYRFNETLPGYQKLFYSTAFSKHRGWNGGTISTIATHDTDRDGLHELVYSGPNGLSVTHATSDELGFDLHNVLDEVSGNQAVRFALPKQLLRNDGPSGIMEIILHTPRGLTWAEIVRYNQGLELEKLHPTNQTTEENVIESSSNKVIPEIVSYRHRTWWLHDQLDLASLLQPLNPHTGSVELTLPLIDLRTPFGIPMRKIFQYKNVDYSNELGQGWSFPLDYIALDRYESAFPQDHVYSLVKDNQRIILTRVNGPEDTTAQPTHEGTRFTIEGYPDIKIRHLEKRNLWEVTIDKRTLTYIVTSQFMTNLVCSTWPLCGSRSLNNRSHPTRWYLSQERDDAGWTANYFYKLVKNGTDIRLESIDLPDYSMVNLGYVDDRISSLEILTMKYKQIVQFHYDRTKNQLLSITQDDRPLFEFEYDEMHRISKIVYPNGVEWTPKYEVLQIDPSALKKRIDFQHDGTVFNGPDYIVIVDAKLADGVLTLHIRDPLGGVGYSGKTNATETVIAVENIKRYLVYALADLLVVTVIYDTSKDVAILQYNEGYGWEQRQYYSELPLESTLTTGNTFVLFADTKTLRLLAVKDGQLTTTEVRSGLPQNFVVHAFPHGYATYDGQLKIFVLQDDGHWITLHSKPEASYFDHLDRFLNSFEIKPELRQSIRRGLLADMLGSYRQAIVLKVPVMRGPVLDILVRFFTMDFKETSEIVDYYTVHVPYANMTEFGYSVSTEDKDTFVLGYRLQANKYHLYVKQSSGPHMVAFEEELKKVHARRNRLLNGRYSATLDKTKKAIAVEYARICKAVTEAIVFAIDLSLFGILVNREGVLTGSHLVTYDGKHWNKQRLDENTLRLRVVNKTLNEHYRLVKVSARDTFKIMSRTNGTMAFDAHTTKPEQLQLIMPYYAQAQASGNPVRMYFFNGDRKETALPADEQLHSASNQMVIITTVRVNETTPKMMLFRCVKYFLNPTITVLGGQTLKPPADLPIVTGYQYDPNDLRVSVDGTMFRRIRILPGADTTRFGWYEQTVDLSTGKTTRRAFSATGQPVIDRKLLEQERKQRESEQEPEAKASDLDKMILDRGGRVQIVDLGPYRLVDEMVSYYGFETYEANHFGKENRWIFNNTLIQREEHNRFLRLSNQMHTLTGQFMPLEPNQYFVVSCWMRTTNATKKGDHLNTLSVDVLIDKTDGNKLNSKTVEVKQRIGDWSYVEMILNTTHIPPASKPIFVVIVAPSSAHPTIDIDHIRFSPLGVPFQANIYEPITGDLQAVLGENGLLKSYLHNTKGKKSILFGEYGEVLEFTMESKVVYARTVTGAHPSLIEMKPRQSFFNRFDQTTSSWRKTGRGWRSNKGSIAFLMTGESASIEKTITGSWTTLALRFLYSLAKSDVVLKLAWGTKEFHLPCGTESQTACPPLPTDGEILVCITAIRISIWVDGVLMQEASLADGSTTGLRDRVFRLHATGGFEIGEFIEMYDPRIKVTYHNLSGQPTQLLVYEDPETVRVREILYDRIERPILQTKWTKIHRKDSDGFFAFYDGFITGFDNDTLVLNGTVAELNPACEGYPYTYTVYDHDPSENKCLQGLPGKQFGVRGKYKREYRSTPSNILLDNLFPSKDGFNQQTTIHPGGAIRVTVEDSRGNKVARYSKVGNYEDRLSTFRYGQKNNKIEQELPPMYHSLAETASMVDFFEFGQQTQRKELQKQWEVRYNYDEQNRVIRKRTPDGGIYQYLYDRYGILRFTLHKDANETLDRVLHFMYASDGKITREALVNLTETECTHLLDGSKVPESTNFIDTLYGEQDTDPNLRYRSKLASRHIDDDQMTEYLVYDQLDRLLKKTFVVNTINTSYSIDYEYENDKLRSIKYPIGQGAKPYKFIFGYNGHGEVTTIQESATDEPLFQFTYNADGMMETMKVRTGTARFFQRNFTYNEPGFLVKLADDFLTEDVSYVETDSYGQDSYTPIYEGLISRTIFTAHWQRTTSSLRTTLFPEDLISNSISRKQAIVCFDVLKQKGYLNEINEVNRTFYGERDDDLPFICGDVIPLNHLSAVLSSGSFPHLYGHRYDYDDHDQLIKAKYFHGSDELQLTPLTYRSFAKEIEGVKESDSKNIWDALLAERFLSSDCTNPNLCHGRPGPKSMFGDFIRQHRYHKHLQTLFSKAIVERKALTGDEFDSRCKRWIEGSNMGKNVCRDIKNSLAKRNLIGNSPQNSLDSLSETFRNALKRYKSQVPDIVRVLSHHFATALGRSAGDVQSYEIDANGNHRMFYTGFSRYRLEYREGTNQITKLHRLYFDRDQRAEEHFNMEHNSDGAVVKAEHKGIKHMEYDRILHRVTKMEMTDGRKLIFQYDVRAERTFKQVLNPDGTVSHEKYYIRDANGLVLVDMELTYLAKDQPPDVRVTSYIYKDQQLVGFVRNDKLYGVISDHEGSVRLIVRDGEVVAAYDYLPYGQIFRRYGTDLDGQISYLYTGQEWEPETGLYNYRARLYDPDIGRFYQMDPKEQYPSPYVYAGNSPVSLVDPDGEFAFAIACLIMSIVGAYIGASSAAKSWNPLQWNWKSRSLWLGLFGGALTGLSIPFNITASVGYFVGLGLSLTASISIMVCSGITFGYFALAAASGSWDPRNFDFASPGTWNALLGGIATSAFIVTTPNSLLTTFRSISTTLGRALFVTVTASLGVTFAYLFGVIRMGGQWDVSKWDFTDPGLYYSLFDGLVTTAFMAVIVRNIPKDLQKWNRKIESSLDRLAETQIFFRARKLMRGDWSFKLSNVRLFISANAQSIARLQRGLLPVAFYSFIVTLRMAESFQNSPVPGISVFLNIISTVMTTRGFSNRVVKPLVGKAVNAPLALRLEGSSTSEDSAHRYITSGSATLSSFISGFRLPHFEWLRFMTSKDDRHNEDINYAKTQQHDLSHKRKHQRKHSQTSKPGHIKNCYRVANGDSDGYFVKCFSLDSTTSIHPKPDAILEAHDTYRRCLPLTYDGTPAISCDGERSSLLSAGVVTPKLIDLVDGWLLLAHITPAAVREAGRILSHIFGGGSSVPTIDKPATRERHRDRLTGKLMHLQTLSGQLHNEWKMDWVAAMVEDVYEDVYEYLAHGRGNSTILFERLEAIETDIQEEMDLHRTKQSVQCLLDRISSSTLRFTESASAVDPLATESRSLWLGSPSALIPRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8P6</accession>
    <name>A0A084W8P6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014629</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8P6"/>
    <dbReference type="STRING" id="74873.A0A084W8P6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014629-RA">
        <property type="protein sequence ID" value="ASIC014629-PA"/>
        <property type="gene ID" value="ASIC014629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014629"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005162"/>
    <dbReference type="OMA" id="EAMKRTC"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014629-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13578" checksum="DF3E368C7A06E589" modified="2014-10-29" version="1">MFAQHFRARVLYAAKRTTAALLSLSNIRQLPLVAKRTKKVGIVGKYGTRYGASLRKMVKKMEITQHAKYTCTFCGKDAMKRTCVGIWSCKRCKRVVAGGAWVYSTTAAASVRSAVRRLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9B4</accession>
    <name>A0A084W9B4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011974-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014814</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9B4"/>
    <dbReference type="STRING" id="74873.A0A084W9B4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014814-RA">
        <property type="protein sequence ID" value="ASIC014814-PA"/>
        <property type="gene ID" value="ASIC014814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014814"/>
    <dbReference type="OMA" id="MAVEDMW"/>
    <dbReference type="OrthoDB" id="6107927at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="81"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="282" mass="31716" checksum="314711C93CB95DCE" modified="2014-10-29" version="1">MCHAVFPKRECENQEPWRESGCTTLPNVASGSVLYKPNKVAARLSCFDATELAGSRDTYCNGTHWDRPLGVCRKTGQGTARDCDFEAETMCGWTNDMLHDFDWKRSDGTLNPRALRTGPKYDHTKMQPKAGHFMIVDSAEQFTNETARFISPLYEPELSIGACFQFYYHMYGETVGSLKVYVKPMTSDLYDLKPSLVLEGNQKNVWHEANIQIPKQSKRFQIVFEASIGMPYKSDIAIDDVSLLQGDKCEDGLETPDDAAPADPEVEPVKITSCKNRCAQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9W7</accession>
    <name>A0A084W9W7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005398-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015025</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9W7"/>
    <dbReference type="STRING" id="74873.A0A084W9W7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015025-RA">
        <property type="protein sequence ID" value="ASIC015025-PA"/>
        <property type="gene ID" value="ASIC015025"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015025"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022594"/>
    <dbReference type="OMA" id="CNACDEV"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09414">
        <property type="entry name" value="LIM1_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09830">
        <property type="entry name" value="PET_LIMPETin_LIM-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000093">
        <property type="entry name" value="prickle-like protein 4 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="78"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015025-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="30547" checksum="990C23C0509663C8" modified="2014-10-29" version="1">MLDLQRHADCPLWDALASPVVPWPGMRYACVKVLHAYCKVFNKQELYDLIVRKTCQECKCPRETHAVYHEQLTTVRDRLGFKHDTNTSRVDPRQMGYTWVPPGILTSAKIQRYFDVIPPEKVPKIGTQGERFRDKQLVYQLPKQDLALDYCKHVEEQHRGSYEDFVAARNEIALDIGYVKDTPQTTKCAGCSDTLNQGEMAVTAPKFREQTLWHPRCFKCTTCDELLVDLTYCVHDDQIYCERHYAEMLKPRCSACDEYTNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA66</accession>
    <name>A0A084WA66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP006674-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00015158</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA66"/>
    <dbReference type="STRING" id="74873.A0A084WA66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015158-RA">
        <property type="protein sequence ID" value="ASIC015158-PA"/>
        <property type="gene ID" value="ASIC015158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015158"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015308"/>
    <dbReference type="OMA" id="ANTEWRW"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784698" evidence="7">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="57"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="31638" checksum="9C542DB9013BCECF" modified="2014-10-29" version="1">MKFASALVIAGLLAVGAAEWIDIDWSQVKPIDEFDHYWTRLPAEVQYLRHARPSARIVNGAEALPGQFPYQIALLSTFAAGTGLCGGTVITNNYILTAAHCVVGGNGALATGGTAILGAHNREVVEPSQQRIAFSQAGISVHPGYDASTIRNDIAVVRLNSPAVFNARVQPIALPARSDARTFAGMEGTASGFGRTSDASPATSPVVMFTRNPIQSNAQCNGFWSTALVQDQNVCLDATGGRSVCNGDSGGPLAVQDGGNSLEVGIASFVSAAGCASGAPSVFVRISFFRDFIEQNSDFVFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAT2</accession>
    <name>A0A084WAT2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015604</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015604-RA">
        <property type="protein sequence ID" value="ASIC015604-PA"/>
        <property type="gene ID" value="ASIC015604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015604"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8244" checksum="7EADBDE24DC1B076" modified="2014-10-29" version="1">MEPFITREKNPGPEREKSIKVKVRPVQLFTFDWPVVELVFKDSSRIRLLPGKQGPNLKFLLPYEEQFNAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB59</accession>
    <name>A0A084WB59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015400</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015400-RA">
        <property type="protein sequence ID" value="ASIC015400-PA"/>
        <property type="gene ID" value="ASIC015400"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015400"/>
    <dbReference type="OMA" id="CWTTIDR"/>
    <dbReference type="OrthoDB" id="8197936at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015400-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1226" mass="131402" checksum="B1224923D4B9515C" modified="2014-10-29" version="1">MWRHRQKTLNGSGTTTTKYSNSSSKESASGLDSSEENHTHEPVDTQSGHRTDTSASGSECPTNGTTASERRTSGAYHRRRPPPYHTRSGWAGGGTGTVATNGRGTYNGGNRSGYYNGGGGGYYGRRSYYDSHSRRPANKTSTSGEGGGDGGGGTTVNDDEYTRITTPRQDVLFKKGYLSRPKPTTTATAVSTSNENTASSSIAGTTSEGSDGGNGGGSNSISTTESITSEYGGSFAADGSPLFDYPYPLLPCGYFTENGVLVMNGFAVDNNGYSYFNGGQTYIYPPNFNNCQQQPPSTVEPTDSMPYPANDETNTNNPEDPLTSTMAEVVVPEGSVTPAADSCRVDVGAGGDGVGNPSLPPTTTSEDHCEPVADLPASCSELQEEAPIDPNAVGDGGLLRREVSDYENGFYQFNDGYDFAQFYSSIYYPSWLMEQYRLYDDTGAPIYCPGEYTMPNGDVYTHQTSFKRRKKRFRHFEEAEGNPPSDALPGGVTPVSGDSTHEHQLNVDVQEFLPSTTTAAPVQNGGSVSSDSEVAKLDKNHSPRVTKKPPPAVKHPKSSSKSSPTGSTAAVGQTNGTATAARPAAAMSHKIRKKDLIESTLAFAEQNIDLTRSKALANGTSSLESELDCWTTIDRNGRKRKEQVAIVKEKQVPTHGEQRPVVEKVASPPVSAPSPTEAVLSENTGTAGSVDTNSKKDQQSTKNKKKTKPNKRQQQRMSASGLHRQHKHEGFQLIEPEFPSTVGHRARGGGAGCDSVGKDDQLDTEDSQEEQHLDEEIPNEESAEEEKKDESVVPENVCPLEVIAEQSKEEESFKSVELNCDKVNETVPAEAPPMTQVEVIEEQQEAQEMVLLATPPQPSPTVSAMEVVEEPIIVKKTETDLHQKPQLEQPMCEEEPSSVQCSLSSVVVGQEEQAIKEDPIVEQPTPRSVAEPVPEDEKLDGTQSPVAIDDQTIGEIYSNKNVLTSAAKQLALGNRRSLQLLQEKDNDVGEEEHGDAGGLEGEDDESRGKRGSVSGVGYTESIDSGLQSPVSPCGGVSSPEASAMVSSLASDETTPGTPPSEEPPKPLTQTVATWLLRKLEVHDLEEVFVLPSDPHLLQRLERFQLLQRGDNRLRTGTFSSDSEDVDDLEDEDSDSDYMSDGQGRQDRAAANGSFNTPSLPVNTEPGASPTENDASLANAKIQLPSEEPAPTKSPVLKPSDSRSINSQAGAPRGAASSGDSKRCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBG1</accession>
    <name>A0A084WBG1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00015519</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01022351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBG1"/>
    <dbReference type="STRING" id="74873.A0A084WBG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015519-RA">
        <property type="protein sequence ID" value="ASIC015519-PA"/>
        <property type="gene ID" value="ASIC015519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015519"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003333"/>
    <dbReference type="OMA" id="SHYTERP"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="404" mass="45035" checksum="917018C8B21A5B93" modified="2014-10-29" version="1">MTKDLALASKPGDTVRYDQGGPGGSSTGYGNFEEIGPLDRTLHERPHTWVNDYHVLFVDSPVGSGFSYTEDPSLLARNSSTVVSDLMAFLKDFYRTIERSTSVDWEATVPLYIASESYGGRTAVEFAYALEQAGRAGTLRCRLRGVFLGNAWLSPLDSIGAWPDYLHRMGYLGEGGRKRVDRRVAAVREKVDQRQLGKAMDGWHALQDAILEETGGLNCYHILKPSGKETFRKDENSDEVLEYGETDWWKSPDASRQLSSLEALMQGPVTHKLGLTSRPPWGAQRNAVFDALAEDFLRSSIGTVERLLNETTIELILYNGHLDLITCLPGTLAWIRRLFDQKEKAFHVTREPFSGDDMDSVVEGYRSAYGPRFTLYTVLRAGHMVPADNPTAMAHILRAHIAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBL2</accession>
    <name>A0A084WBL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015576</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022367">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015576-RA">
        <property type="protein sequence ID" value="ASIC015576-PA"/>
        <property type="gene ID" value="ASIC015576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015576"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8141" checksum="7EA6B618A143342E" modified="2014-10-29" version="1">MVAGEGATGSDREGEFGSVYGSAILEIELMLHWRGLHATGARRAGLEARTPLMMRACNSSIRCRSPSPPEESHITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBT7</accession>
    <name>A0A084WBT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015727-RA">
        <property type="protein sequence ID" value="ASIC015727-PA"/>
        <property type="gene ID" value="ASIC015727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015727"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015727-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="7993" checksum="0370205B12ACE11A" modified="2014-10-29" version="1">MLLPRSSRFARFAESPSCRRCADDSHPPDAAMHREAANFSCSPAYALSVPAPSGLRATGTSSRISAKGRETGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD20</accession>
    <name>A0A084WD20_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016090-RA">
        <property type="protein sequence ID" value="ASIC016090-PA"/>
        <property type="gene ID" value="ASIC016090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016090"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7186" checksum="821E661FF4F14762" modified="2014-10-29" version="1">MPCVNGKSDDDCWHVTAAAAECPEGLCTSSWAACCTCFPPPAPSEPVPSGTVTSHYESSGPIRMGKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE03</accession>
    <name>A0A084WE03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016428</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016428-RA">
        <property type="protein sequence ID" value="ASIC016428-PA"/>
        <property type="gene ID" value="ASIC016428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016428"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10508" checksum="FB3A0B0CD577579E" modified="2014-10-29" version="1">MTNCIHTHTVSRGAEENCNREVLNHEFALVKNVALQSPEEVPVAWSQDLASSSDGECILQLFNSRWLWRIPEMLLPVEPGPKGPPHHAVSLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEK9</accession>
    <name>A0A084WEK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006349-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016647</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023221">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016647-RA">
        <property type="protein sequence ID" value="ASIC016647-PA"/>
        <property type="gene ID" value="ASIC016647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016647"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018867"/>
    <dbReference type="OMA" id="VWKSFEN"/>
    <dbReference type="OrthoDB" id="18814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="488" mass="54249" checksum="9E9CCBCF0AFB0F30" modified="2014-10-29" version="1">MQPWLRVSLLLCVFGFFRELRPSEPFVTEFLSGEWRDIEPEQLNRDVYPIGTYSHLALLVFMFLLTDILRYKSIIIFSACLGIVIWSLLLWTESLAALQVVQVLYGTYMALEVAYYTYIYAKISREKYQQVTGNTRAAILLGRFLSGVISQVLVSTGAMNVRDLNYITFGAQTFSLLWSFVLPPVRTSVYFYASSDDEQKPGQHQQLENRQSDGTVGNGESGSSTPEPAETVQNTPGATQRQQTDADKGGHAVKPAVVSFSAKRAVRLLWHHLIAAYRQIPVVQWSLWWALAMAGFIQVQVYVQLLWHEIDQDQGTLFNGGAEALLTLLGAASAMVAGYVANRIFERWALWILTVCSGLQGGLVLYSGFATNIWVAYVLYILFGALYLFMITMASAIVAKYLEEDSFGLIFGINTFVAIGMQALLTLATISERGLMLDPREQFKVYGGYFLVLSVIYLIAAIVTGIRQLLSGAAVEGQEGDGTPRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEP4</accession>
    <name>A0A084WEP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006165-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023241">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEP4"/>
    <dbReference type="STRING" id="74873.A0A084WEP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016687-RA">
        <property type="protein sequence ID" value="ASIC016687-PA"/>
        <property type="gene ID" value="ASIC016687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016687"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004495"/>
    <dbReference type="OMA" id="SQLYTQD"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1167" mass="122513" checksum="8A5C31224E894603" modified="2014-10-29" version="1">MERMPMWCPPTPPQDDNDLYVDHSLTFLYDTSDIIPEAELPPVYVKKDHKRSRSEAGFCPEGRRPPKIRREDTYYAPRSLFDRPTPQIAKLRKEYKLQRYKGIIKPFPPMLAVKPNTVPMKPPVEPEGLPEWTVYEDMAILNVVQNLQGLPLNLMVISPGHTPNWDLVADIVNQTSRTHRLPKQCRYRYESVIMPREEGKLLESPKKQKKNKNPLKQGTNGSGGVASIGQSVPPKQIRSMRTGQLYTSDANSSFIKLMRQKFDNIKTAFAAKKPAPVKPSLSSALPTVLKNPKHALVLAQNGITNYDNPLTPATIVVCSVPTNATSTVATIVQASTLQAAAARAGGSVVNICASPNQAQSQQQHIVKAIVASPASQNLLSQQLAQVAAAQQQQQQNSNLQQQQQGGQQQVSVVLTTPVTTMSGVSTVQLSSQPQIVSIHQPVSSQQQQQQIALQTSSTASAVSQASIVQTLASQSMPQVVSVAQLASSATTIQPTQVATLTTSALRAQRIVAPPGTLHEVVLQRSGSQSPTVVSLGGGLTQAQLQTAQLRLSMAGAQQVSGVVAKSISVGTVTTAGKPINTPQIQFYRQQPIRQQLKVLHPGTATQVGGGTLQSGGPGQPTIVSPAIIQGNIIQTGGTVGQTVATAAGQKVLPGGVVSSAQVTQVVSAAVNVSAGTQQQQQPTPTVASVATVQVAQGQPRMQYIKQLGGTKHMITRPVTENEMQLMVKRQIISQQQQQQQQQQQQQQLGKQQLIPQTQIFAPASLQVQQATAAGTSTGQQIATLVKTSGGTAVAATGMTLSHVKPGQLKTISSQQQVRQLHLQQQILAQQRKGAAKMTQITQVAGKAGQPTQLFVQGPKNLGGGTTTMTMQQIQQVIRHANPASLASGGQIVLGKTGVGRMIPVSVSQQPNQGQTIQVGSIRAQMPRQNIGTIKVAGGATTAQQQQVILNAIQSQQHAAAAAAARSNASPVRLQTTSSGSLVAVTVQQSPQQLQQQQQQIGVSVSGPSSVTVATTGATSLGGGAGVEAVSQSSQTTSGANSVTGSTTVQSIIGVPQVVTLQQQPSGGQQQPTAQLMTTTATIVQSAAGGTTSTSEGLTSSTTTAGTVASATSAGGGTTGGSVVAVASSGGSAAQQSQQQQQQQTATNAQQQQQVSMIKKKQSPNVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFN7</accession>
    <name>A0A084WFN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011197-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFN7"/>
    <dbReference type="STRING" id="74873.A0A084WFN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017041-RA">
        <property type="protein sequence ID" value="ASIC017041-PA"/>
        <property type="gene ID" value="ASIC017041"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017041"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020530"/>
    <dbReference type="OMA" id="CKEAPAY"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784655" evidence="1">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017041-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="40896" checksum="A318E7D963601E84" modified="2014-10-29" version="1">MYHPNAGRLVTLLSGVVLVWQISSGSAEEVSVAESVAGYGFEVMMAKLDFLQYKLYEIELGMKERDEEATERLTKLEDAISGIQWAISTHDRDAAHNLTVLHAQSQKILAQQTACANHEKMRQEIAQLTKNAAILRNYTSIAGNSRKVTTFKSCKEAPAYKSGVYTIQLAEMEDKFDAICEQYSFGGGWLVVQFRFNGSVSFYRNWTEYQHEFGSLDHEFWIGLEKIYRLTSRRPHEIVIEIKDFDGNWRYACYDEFEIGSSSEQYVLKKLGAYNGTAGNGMFKGKGMGFSTYDKDNDKDSGKNIALTYRGAWWYDYTLDTNLNGKYMNATDMSSMSWFHYKGNFQGLAYSRIMIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFQ4</accession>
    <name>A0A084WFQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017060</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017060-RA">
        <property type="protein sequence ID" value="ASIC017060-PA"/>
        <property type="gene ID" value="ASIC017060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017060"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="18864" checksum="F5D4F2FCE17A5307" modified="2014-10-29" version="1">MSENELDKTLAHAIQPHDKVHRATSPQQLQSQFPNLEAAVHYQSNIDPNPAGIRQNYYRIPRNFQPPQSTTNKDGPRVCTSLPLYLTKVFRISNIIELTISTGFDTEETSGPPLECNIGHRMRQPIFVSRHCRQDAPRCVSSSACRKKLLLLRPAAADGLLMSFKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGC4</accession>
    <name>A0A084WGC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Arginyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017380</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017380-RA">
        <property type="protein sequence ID" value="ASIC017380-PA"/>
        <property type="gene ID" value="ASIC017380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017380"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="231" mass="26226" checksum="156636ACA1290FDA" modified="2014-10-29" version="1">MRPPFIILSALIPTDFEQQQQQKMQTVGTSFLGQPLSFTFHFRRGAYQPLQQQIAPIVTVYDLLIHESADGSKFTSPNVPIYRIRKRERWRSSGSAEDMEPHEVSSTAENHSIIMLQVDSVRKRKEVVFRSIKCRCGKKETQQPTAKVAPKGNENNIIPTFLYPTLWKELGVGCVRPRRKEAYGSPPTNPILLPGGCNCIVFLRSRHERNGVRAAHGSGFSLSRFELNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGP0</accession>
    <name>A0A084WGP0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023648">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017483-RA">
        <property type="protein sequence ID" value="ASIC017483-PA"/>
        <property type="gene ID" value="ASIC017483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017483"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="8918" checksum="012D68BCDDBAAE03" modified="2014-10-29" version="1">MVGSSGGSSTFEGKQVKIPLPSPSNSQGHPSCVGCARGNPQLMASDVAVWLCSFYSRKDQQRAARVKSLSLIPGNNRWKNPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHT8</accession>
    <name>A0A084WHT8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017798</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHT8"/>
    <dbReference type="STRING" id="74873.A0A084WHT8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017798-RA">
        <property type="protein sequence ID" value="ASIC017798-PA"/>
        <property type="gene ID" value="ASIC017798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017798"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017106"/>
    <dbReference type="OMA" id="KWLMDGI"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF24">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017798-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="20392" checksum="87DD5277F36BF38B" modified="2014-10-29" version="1">MALERQVRMKIAGKRDLEKDKEAQYWIEEVLGEKFPAGVLYEDALRDGLILCKLINKLEPGAVAKINTSGGQFKMMENINLFQQAIKKYGVPDLDVFQTVDLYEKKDIAQVTSTIFALGRACYKHPEFKGPFLGPKPADECKRNFTEEQLNAGQTIIGLQAGTNKGATQAGQNIGSGRKIILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIL5</accession>
    <name>A0A084WIL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP011909-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00018108</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023937">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIL5"/>
    <dbReference type="STRING" id="74873.A0A084WIL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018108-RA">
        <property type="protein sequence ID" value="ASIC018108-PA"/>
        <property type="gene ID" value="ASIC018108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018108"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020240"/>
    <dbReference type="OMA" id="NTPEWNY"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035008">
        <property type="term" value="P:positive regulation of melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160032">
        <property type="term" value="P:Toll receptor ligand protein activation cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000015">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="166"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="408" mass="43761" checksum="02C7C72383DA3A1E" modified="2014-10-29" version="1">MLPPRKRNRNSQKDPPGTVLLLVCTTLTPALIVQAQYSGCDYSIDVASGQSYSIYSPYYSGFYPAYTQCRWTLNTTPGSRIALYCSDISLPTSNGCSTDKLIISTGGQSNLSDGNTYCGAGVLNTESSSNKMVIALQVPGTTNGGRFYCTATKIDCQCGMRKRKKIVNGEETLVNEFPMMAALVDGSSGEGIFCGATIVTNYHAITAAHCFMGRSIGSLALLVGEHDITTGADSPYTALLLLASVKIHESYNPTTRNNDIAIVRTRTEISFNAGVGPACLPLKYDGASFVGITLEAVGWGTLDYGAPKSNVPMKVGLAVVAPAQCTAVYPNFSTTQQLCVLTANKDTCQSDSGGPLFYTDAYNQRVYLLGTIGYGIACASDNPSVNTKVLNYMQWIMSNTPEWNYCYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIP3</accession>
    <name>A0A084WIP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP011883-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018139</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIP3"/>
    <dbReference type="STRING" id="74873.A0A084WIP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018139-RA">
        <property type="protein sequence ID" value="ASIC018139-PA"/>
        <property type="gene ID" value="ASIC018139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018139"/>
    <dbReference type="OMA" id="LNRMINQ"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF141">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="212" mass="23086" checksum="D7BFA08EA444BB83" modified="2014-10-29" version="1">MENLSKVLSMNRQPLSGQLYKYTNVVKGWQYRWFSVDAQAGLLSYYLCEPSGDDSSSSHIVSGPPRGQVHLAGAVICPSDEDSKTFTVNCASGDMLKLRAVDARARQEWVDGLRAIVESHSNSTGTALPPRDQLAAHDAFGAARQQLQQTELSNAALARAIENLNSPLSHTDPDLLVVKALSAASTHCLLQCLGLLQRHQELAPDSRLEQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ57</accession>
    <name>A0A084WJ57_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011772-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018328</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ57"/>
    <dbReference type="STRING" id="74873.A0A084WJ57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018328-RA">
        <property type="protein sequence ID" value="ASIC018328-PA"/>
        <property type="gene ID" value="ASIC018328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018328"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007100"/>
    <dbReference type="OMA" id="PSIDAHK"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:midbody"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
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        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="707"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="964" mass="106543" checksum="20B4A68834EE8F0C" modified="2014-10-29" version="1">MDELMELFDNFIGDALQLEKAMEEEFKEFEKKLNDCVAQANERGTPVQNKKRPKRQVSISEKDESTNSSTRQEEEGTSKQQPVKSMASATSRSTVRMLDVFGNGNNAPVPGSAQQSMETAPIEASFARPSRSAALKAQEKLKEPTLNSKMRNESFTAVIVKKERQSKIEADGKNSAVGSGKPVPQNDQYDEMETENDANYANRNIQHDTQHRKDEGFGSTNESSEKDEPAMATAKPTSHEASIMVVPLVVPKVEVLSDEEMPPPKLPPPKMPAPKVRTKKKATAKDQKLADEQASSSAVSSAESSINGSSSSLNDTQQGARRGRGRPTKASKVVPPPMEEESIEPVRIKTEKLSIVDSNQQQKQESNTSSKSIYEDAQEQMEQHQIRPLQVVLEKIVFPPANRSRASDMNGTFTTGKSQANETYALPPSIQDGTFTVNSPPNTAPCNETFNLPTQGIAHQPQTGTNDTFVIEKTGSASKEHDAAANYHKTLVNASIMTEDDSVVENSPNQAPMLPAMKPKPVVAGPSAKPKKSSASTSVSKKGSSAFPSSSKQQQMKDNNELFNPCIMSPIKSRIQAFEKCASTTTGTLTKATTSIGTPQPRVGRVLKTISTPSLATTPQFSSLESLGSAAHSAQPKETVYTPNCATQPLVKAVSASKIHQMQSKALHSKFGTNATTGCGGTARSLSRESSSDRAQGQGGGSGGGTLSAASSISSLLDEKKKKREEKQRLAAQQREAMEREKREHAERLLREKEEKYRKLVQEKQEKIRLDACRKAKKLEEFEKRRQLEEQRALADQKREALAKQLEQQRIDRELLETLKQSQMKETQETKLHKQMVQQKLRQQQLQQEQQQMAAKKKAAATKKETFKFEMIDTDDTTDDDEAEDVAARKKKRPPTPEWCQNTAEFRKTLTLQAMVDTKVVDRLFSVQPMTPDLRILFPSIDAHKLKRNSSAIWRTPPRQSQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ85</accession>
    <name>A0A084WJ85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP011817-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018358</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018358-RA">
        <property type="protein sequence ID" value="ASIC018358-PA"/>
        <property type="gene ID" value="ASIC018358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018358"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003437"/>
    <dbReference type="OMA" id="RFKQLIF"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB50279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="448" mass="51570" checksum="2A52BD8DB8253BD0" modified="2014-10-29" version="1">MTITSRKYQRTNFVTTSNTLQGSYGGSSTNNDTNNGPTTGSGGTGEENADSLYTPFPKHVPYPNVDHSSELLNEFIIFFFTIIACMTQFVHLYRTIWWLPNSYNRKSMNFYLIDWDLAIFIDIMVSRRLLYCCILKFIDANCPELYVGLCKKVAKYTFLTFMVVSSIFCGTQIYQKTSYFHLLVLCYPLVLYLVIFGINLEQFLRTIVDTEPNCINGMPLHSCSSNAGSIRTEVEALKADLNNRFKQAIFTSLLNAYYAGLVPCVLASKHLYYNKFWTTQHLVCMFIGGFTMCITYCFPMRYCDVFHRAALHLGQWNRVNSRTTNFPTVTWSKTGIFPYGTYVRHLGEVYRAVGSCTSAIPANNSHYRFFAIFRNPIIIYLVLFVVQMFMIVVQLAMLVMSREWQNGLSIGFVLLTNFFTLFRIARDYFIARRVYASEMLSHSKLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKI6</accession>
    <name>A0A084WKI6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018775</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018775-RA">
        <property type="protein sequence ID" value="ASIC018775-PA"/>
        <property type="gene ID" value="ASIC018775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018775"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="10156" checksum="3E4C56FD688923A4" modified="2014-10-29" version="1">MTKLSHMFPTPVLSNTCMRMVIIVPAEMFPRRLFLTNSPEFCPDRDRSALSWSVGHLRLFVRSRECTSLSGLQIINGSRVVSTESQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKR0</accession>
    <name>A0A084WKR0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00018856</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024134">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKR0"/>
    <dbReference type="STRING" id="74873.A0A084WKR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018856-RA">
        <property type="protein sequence ID" value="ASIC018856-PA"/>
        <property type="gene ID" value="ASIC018856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018856"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011910"/>
    <dbReference type="OMA" id="DYAMQNT"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="237"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB50804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="385" mass="42867" checksum="85CD0ABDA83B3A3B" modified="2014-10-29" version="1">MDASTESAKRTKFEHLVVDTSAFIKNVQLQHTAENCYTVPGVIQEIKHDRQLKALAVLPYSLKVLMPDPDALAKVIAFAKKTGDFATLSLVDLEVIALTYELEARYVGVGHLRTEPKPAIMLTEPNDSLALMDTAETAGFFKPKQANLEEPDNEAAQDEEDPSDREYDGGDNKNEYGEDDDEGWITPANIVQANRGYGMNYIEEKPSSVACLTTDYAMQNVLKQLGLQLATMDGRVITQTRTNILRCYACFKTTPDATKVFCPRCGNQTLKKVTVSLDANGQQVIHINNRRPLTAKNKNRPVAKFAGGKYATNPLLYEDQPLPQQRISAKARNKTNALAEDYIAGSSPFVMRDVNSRSAVLRGSTNLKQRIRNLECDNKRRGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL64</accession>
    <name>A0A084WL64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018999-RA">
        <property type="protein sequence ID" value="ASIC018999-PA"/>
        <property type="gene ID" value="ASIC018999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018999"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="22749" checksum="78D85D4DD0C38D9E" modified="2014-10-29" version="1">MAMKVVILKQSVSPFGRPGDELRYEAGGCVRRLCCTGRPGAVHNHVPPRTSEPDQNPPDVPTGRACPPIIDMNSTITISPARRKNENHRRYLITRTTLRSMHSVGLLPPPSPPPEANALHPVACFSFLFHSGGFGCLSQNVVHCSLALGKNSLVPDFHPKPRGRTVPDKNFTITSVHLLQLSSTLQGGWAAWVENTEPYRFSNSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM78</accession>
    <name>A0A084WM78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NAD kinase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019376</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019376-RA">
        <property type="protein sequence ID" value="ASIC019376-PA"/>
        <property type="gene ID" value="ASIC019376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019376"/>
    <dbReference type="OrthoDB" id="6763155at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="9134" checksum="8F952200D6773A37" modified="2014-10-29" version="1">MREEDLILARAIVAQQQDASPGASPAPLRRTLVTNLQDKTKQFRPYQGADLSIDRYGNKVGEAIYGLIDRYLSDAASARNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMN7</accession>
    <name>A0A084WMN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019537</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019537-RA">
        <property type="protein sequence ID" value="ASIC019537-PA"/>
        <property type="gene ID" value="ASIC019537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019537"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022932"/>
    <dbReference type="OMA" id="HERLMGR"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019537-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="22237" checksum="21B82F7EEF117BC3" modified="2014-10-29" version="1">MLNRETGEMEYDTVGGYDRERIYLDKETGEVSSYPAEPTTSGHRRRSKFLVPKQYLRNQSGIVARRPASATVGCAAAISNACKQKMIPMTKEEITVGYNSAAHLLYLLPLLFMTPKLFALVISFVEMILHVWAHRKTGTNGNPSVYYRSPMHVVTRNFCEVCRHERLMGRVGKLQDVRMKQMQNYFRKVTRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP69</accession>
    <name>A0A084WP69_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006437-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020192</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525365">
        <property type="protein sequence ID" value="KFB52013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP69"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020192-RA">
        <property type="protein sequence ID" value="ASIC020192-PA"/>
        <property type="gene ID" value="ASIC020192"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020192"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014833"/>
    <dbReference type="OMA" id="IECKNDI"/>
    <dbReference type="OrthoDB" id="7742987at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020192-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="41776" checksum="6807A7AE9D90CFDF" modified="2014-10-29" version="1">MEEVAATIDVSDAMLGADAAAADDAPVPLQEFKWTRESCLLLLHEYELLKDKFKDRKNKKKDLWAEISMKFKKIYACDLEWDVAYKKFRNLKQTFEQVRVKLNQQAMLGQVSNRPKWPYYDKFVQILDDSPASYSYTTEQHQLPVEHHLQQHQEQLDHHSQLVEHHQQIVESVEQHHHHHHLQQAHHHHHQQHQQQQQQLQQQQHQQQQQHLDPGSVGQMIAGEEEFTETLVTAFPMGEELEIPSHPPEDTPPDVISKTEEDEIVGQMPAAEEEYAEEEDEEPEEEVVQDEMEPPHRKRYRRRTSYQQERLEIEREKLHTLREIQRGIECKNDILQGILHVLQAKVWQAHPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP81</accession>
    <name>A0A084WP81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP002195-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00020206</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525366">
        <property type="protein sequence ID" value="KFB52025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP81"/>
    <dbReference type="STRING" id="74873.A0A084WP81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020206-RA">
        <property type="protein sequence ID" value="ASIC020206-PA"/>
        <property type="gene ID" value="ASIC020206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020206"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024479"/>
    <dbReference type="OMA" id="MCINEAM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB52025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020206-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="362" mass="41384" checksum="AB90B7982E6BF6F8" modified="2014-10-29" version="1">MLASFVDTFNEKDFIMVETLKKYVGKGEIDLHLHVAKCNIDAFFSTSFGKDLNSQSHNEADAYLNSLETFFALIFKRVVSVHRYPMWLYSFTDDYKTETKCWDDIRAMSKRMLQERKQHPRQKEVQHNSDVFGRKPALNFVDNLFDAAEHNSSLTDEHIMDHINTIIAAGHDTTSTTVSNLLLMLAIHKDVQEAVYQEVMSICPDKSKPVTTEEANGLVYTEMVCKETMRLFPVGPIIGRTCTAEVKLDEKHTIPEGCSVVVGIYQLHRDPATWGPEPDVFNPDHFLPEKVAERHPYAYLPFSGGPRNCIGIRYAWLSMKILIAHLVRNYRFSTSLKMEDLTVKLAVILRITNGCMVSIENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPG9</accession>
    <name>A0A084WPG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Lipid A 3-O-deacylase (PagL)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020430</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025076">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020430-RA">
        <property type="protein sequence ID" value="ASIC020430-PA"/>
        <property type="gene ID" value="ASIC020430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020430"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020430-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6376" checksum="452EC7E7DE03A1E4" modified="2014-10-29" version="1">MWALPQRPVDRKDLSLKTPENGVRCVCLPQLAFFYYPRRTVPAREGEGFVGEEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQX8</accession>
    <name>A0A084WQX8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525400">
        <property type="protein sequence ID" value="KFB52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQX8"/>
    <dbReference type="STRING" id="74873.A0A084WQX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020872-RA">
        <property type="protein sequence ID" value="ASIC020872-PA"/>
        <property type="gene ID" value="ASIC020872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020872"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016321"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="95"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="312" mass="36275" checksum="5DF4AD9BB8916B7A" modified="2014-10-29" version="1">MLRRQARLRREYLYRKAVEGKHKAQQDKKERIKQALEEHIPIHGDLRKEALALQEKLKWTDQGPKRAAEIGGESGGANTVDSKDDEYRFAGCEDPKIMITTSRDPSSRLKQFVKELRLVFPNAQRMNRGNFEMKQLVHACRANNVTDFIVVHEHKGVPDNLVISHLPYGPTASFTLSGVVMRHDIPDIGTMSEQKPHLVFHNFKTKLGERTMSILKYLFPVPKEDSKRVLTFANHDDYISFRHHTYKMVEKQLELTEVGPRFQLKLYQIKLGTLDELDAADTEWVYRPYMNTASKRRFLSDDDGWQQDDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR01</accession>
    <name>A0A084WR01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020898</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525401">
        <property type="protein sequence ID" value="KFB52645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020898-RA">
        <property type="protein sequence ID" value="ASIC020898-PA"/>
        <property type="gene ID" value="ASIC020898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020898"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10270" checksum="DBB251214850411B" modified="2014-10-29" version="1">MSLCGTQGHNNYRSDALSRSYRHQWQRPIVVSRCLITAHFVSLPGLKSNAVKCPETCRCTSCTIMTSATAPRWPAGGGNRHDFEDDSFEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRK4</accession>
    <name>A0A084WRK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021120</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525406">
        <property type="protein sequence ID" value="KFB52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021120-RA">
        <property type="protein sequence ID" value="ASIC021120-PA"/>
        <property type="gene ID" value="ASIC021120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021120"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6636" checksum="CF4E88B67F38EBED" modified="2014-10-29" version="1">MWKRNNAVQCRANPHVNNLRSIPPLGTADLSTEDMTRHFRHPAVRFPLRSNSPGALDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSH6</accession>
    <name>A0A084WSH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002090-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00021472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026551">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026552">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021472-RA">
        <property type="protein sequence ID" value="ASIC021472-PA"/>
        <property type="gene ID" value="ASIC021472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005065"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009785"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016959"/>
    <dbReference type="OMA" id="RTYVRNT"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="206"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB53170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="859" mass="94914" checksum="3C4E415B6AD21354" modified="2014-10-29" version="1">MPTLVNQSEDCLYLNLYVPHADETPHRLDHLKPSIVYIHGESYEWNSGNHYDGTTLAMNGNVIVVTINFRLGVLGFLKTGAKGSAQGNFGLMDLVAGLHWLRENLVAFGGDPAKIALMGHGTGAALANILAVSPVAGDLIHRVILLSGSALSPWAIQRDPLSVKRKVAEQTSCAGDVVNEDLAPCLRTKSLAELMNISLSSPSPPNEYTNWERSPRSAYGYRDAVLELLSDGLTAAPLVQLSHLHSLQGGRSYFLHFKHQSHEWKFPQRSGSVRGEDVPFALGFSPSPMFPLTLTRLDMQVSSAVMRYLCNFVKTGNPNGLRSSRMDVFVNSNNKRSWNPAKKPHNETLMRQLVTSFRGQTVAAGAGASATGSDSSERPQELLMQQQLQQYYHKDRQQKHSRKKRKYANDLQRFNSRESDDGYGSSEEVGGDQDEQEQGGGESDGRGEPESSYYSVDSDFVYSGFTAIKYNLPFWGHYDTTNQVFMEIGSKVVPKSHYRGHKLSLWLSLIPQLHSSFNIPELSMRHHHFSEENPVFYDGLVREQIVEPPLMHIGFVTSTTSKMHKTETIASTILQSISTECPPNITFIQTASASWPLHNSALPAQHGDSNRSLINRLTNSYHRSYSTALAITIGVGCFLLFLNVLIFVAIYYQREKRESNSRMKINLLELESRLNVVESSSAAVAAAGKVAAASANDDNSSSSDPAVPPLQLQDTEQPSKGSGPTISRAPSKVSSGGGIQTIELALTPHYHGHATHTMRRSSTSAIKHSHKCELQQQHHLAHHHXXXXXXXVVVGFYLEMTVDSSWFHGLSGRFSPALVVQFSRKPNPHPPLRATNLSFSSEEKDEFHSSYKAVVLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT53</accession>
    <name>A0A084WT53_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Dentin sialophosphoprotein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021714</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021714-RA">
        <property type="protein sequence ID" value="ASIC021714-PA"/>
        <property type="gene ID" value="ASIC021714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021714"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10889" checksum="8154EEAE22407125" modified="2014-10-29" version="1">MFPPTALGEKSSLVAKSCRDKLSLTLCTGTVAEATSGQTCSDHVRHVVCFADNMRLRGNRRATNKKHLLRYYTTNPCLVVGVKRPHLTRRPTPAMYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTE6</accession>
    <name>A0A084WTE6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polysulfide reductase NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022000</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026885">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTE6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022000-RA">
        <property type="protein sequence ID" value="ASIC022000-PA"/>
        <property type="gene ID" value="ASIC022000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022000"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="17488" checksum="604206B9AA15D731" modified="2014-10-29" version="1">MFKSTHVIALPSLTPLCQRIEERSPNVQSLYAKFAICGKRTLARPNRSSCSVATSSPTSAEHQCFVSARQQHSLLTFSGKSYVNLTVTVNHCRQSASELLAVAFSVSTNVGNTSLHPKCSSPMVGSHFAQSEWVHVVRHKIGRIISSHSFEVRSVATYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTG4</accession>
    <name>A0A084WTG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021735</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021735-RA">
        <property type="protein sequence ID" value="ASIC021735-PA"/>
        <property type="gene ID" value="ASIC021735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021735"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9350" checksum="7A930C5BC5B0263E" modified="2014-10-29" version="1">MLKPIAAVCDARQVLCDPDVLLNKRRKRRPCMSGSTSETAKIQHRSGDDRFGRSSGSDSGCGCRLGKWSSSKKECWSERDVGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTJ3</accession>
    <name>A0A084WTJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004167-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021767</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021767-RA">
        <property type="protein sequence ID" value="ASIC021767-PA"/>
        <property type="gene ID" value="ASIC021767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002184"/>
    <dbReference type="OMA" id="VIAEMNI"/>
    <dbReference type="OrthoDB" id="9970076at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="381" mass="44036" checksum="01D62524BB76C500" modified="2014-10-29" version="1">MYESDLHFDDLPFELMCEIFDYLPLRDVKNAATVCRRWNAIIFSEVYIHRFRLLLNLDQSLPKLKQMVQLLESSEREYYSVVLRANLGSPLTDARLRVVKLMIRLLAHCAESLYFNMADFRIESCVSERLLRGRKLQIIDTRAKYIPLGMGLKESMLGAICEYAVELVDLVIAEMNIVNPRALEPLSSLRCLKLLLISDYYPYVKPPAPPIDLPNLENLSLIKVTDESCHYFRVNNLKRFFIHSTGTDAPRTMDFITQNITGITRLCLHFTARSIQAEVIFGWLDRFPHLLALELAGVALPVDVLRLLSPTNRIQKLIFVSCHLEAILMDELPAKLSRLRMLCFDGCSLFHKQSGFHPIHYDDIEQLRQALPRCQIMLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTJ6</accession>
    <name>A0A084WTJ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00021770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTJ6"/>
    <dbReference type="STRING" id="74873.A0A084WTJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021770-RA">
        <property type="protein sequence ID" value="ASIC021770-PA"/>
        <property type="gene ID" value="ASIC021770"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021770"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011111"/>
    <dbReference type="OMA" id="CPQRVMV"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB53540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021770-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="201" mass="22719" checksum="55B642743CC4C85B" modified="2014-10-29" version="1">MDFYYLPGSAPCRAVQMTAAAVGVELNLKLTNLMAGEHMKPEFLKLNPQHTIPTLVDNGFALWESRAIQIYLAEKYGKDDKLYPKDPQKRAVVNQRLYFDMGTLYQRFADYHYPQIFAKQPANPENEKKMKEAVGFLNTFLEGQEYAAGNDLTIADLSLAATIATYEVASFDFTPYPNVQAWLARCKANAPGLRAEPGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTM3</accession>
    <name>A0A084WTM3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021801</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTM3"/>
    <dbReference type="STRING" id="74873.A0A084WTM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021801-RA">
        <property type="protein sequence ID" value="ASIC021801-PA"/>
        <property type="gene ID" value="ASIC021801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016585"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000594">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000017">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="210"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB53567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="503" mass="56987" checksum="F87B6F0C9D851574" modified="2014-10-29" version="1">MSSTTEETNHKTAAPAATAVAGENAPENPLQAKADELGVLGNEFFKEQNYERAIALYTEAIETCPNERFYANRSFAHFRTESYGYALSDADKAIALKNSYTKAYYRRAAALMALGRFKKALADLEFVAKRCPSSKDAQDKYSECKKMVNKIAFEKAISVQHQEKSVAKMCRDLEFVSIENDYNGPKLENGKVTLEFMKSLLEWYKNQNKLHKNFAYRILCDMEALLKTQPSLVEITVPDDAKFTVCGDIHGQFYDLLNIFEINGLPSTTNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLSRGNHESFNMNQLYGFTGEVVSKYSQNMADMFTLVYNWLPLCHLINKKVLVMHGGLFSKDKVSLDDLRAIDRNCQPPEEGLMCELLWSDPQPQPGRVPSKRGVGIHFGPDVTDEFLKFNNLDYIIRSHEVKAEGYEVDHDGKCITVFSAPNYCDQMKNLGAFITLKGNDLKPKFTTYKEVPHPSVRPMAYASPLSLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTW8</accession>
    <name>A0A084WTW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021909</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021909-RA">
        <property type="protein sequence ID" value="ASIC021909-PA"/>
        <property type="gene ID" value="ASIC021909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021909"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="251" mass="27974" checksum="8F530242FD5B0CEC" modified="2014-10-29" version="1">MAKAIANQAIESTSNCYVVSPCTARSAVTLSPSSDAHDRADPAVRNLMAASKVRFLRYFYYMLFFFAPFLPAQPEESPELGDRPQTPRTSSGKLQQKEIHFIEIIYHYQTINDLISLHPYGTDAVWWRGRLTGLRKTRARNESCPVSLNSLRTLPVSCGVSGVRLDVGKHCHCRSPLDEICPRGHTLHNDGSPPSWYPRGAREHMPRIAPTPTPRRGAVLMREAQGLHGAVGLHHHCTKDGKSLGRLLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU29</accession>
    <name>A0A084WU29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP009745-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00022101</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU29"/>
    <dbReference type="STRING" id="74873.A0A084WU29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022101-RA">
        <property type="protein sequence ID" value="ASIC022101-PA"/>
        <property type="gene ID" value="ASIC022101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008698"/>
    <dbReference type="OMA" id="PSNRYRI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="567" mass="63134" checksum="D187F8FBA4BB5E1B" modified="2014-10-29" version="1">MALLVKNTFQGCSGWRRRRRPIVHGRPLRRCCRTAEKAKEKIENSEQHKDDAFREIIASCRSLSKYETNIKSALPQILSAIVAASFHIVIGISLAYSAILIPQLEMPGSDIQITKGQSSWIASIIVIMVPIGSLVAGVMMEFLGRLNTIKLAAVPCVAGWVSIALAENFTWIMVGRVLTGFACALGTSPAIVYITEVARPDMRGSLISSGPTLASLGMVIAYAKGAFLHWRLVSWICIIYTVVPVLLIQLFVPESPVWLVSKGRIEDAARSLRFLYKKYPQPEHTERETKIAEAEKNVDRHGVQQSKLRGFLRPTGYKPMIILFWFFLIQQFSGIYITLFFAVTFIQDVGTEVNAFTASIFVGLTRFTMSLLNAWLLKRFPRRQLVMVSTTGMAICMFVSGLFTLWIKEGTTTLTWIPVVGLLLYVCSSMIGLLTIPWTMTAELFPTDIRGIAHSISYSMANLLMFFAVQSYRTITDLLGGAYAVQWMFAVVSVIGFFFALFFLPETHGKSLAEIEAFFAGKAPTTQRTPAAERAAKPSVTEHLIRSPSREAKLKEVELMLKNKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9U9</accession>
    <name>A0A084V9U9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Molybdopterin converting factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000098</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523882">
        <property type="protein sequence ID" value="KFB34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000098-RA">
        <property type="protein sequence ID" value="ASIC000098-PA"/>
        <property type="gene ID" value="ASIC000098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000098"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7287" checksum="84BC4CD2B7CA8FC7" modified="2014-10-29" version="1">MEVKNESEEPMAVKEEYDSDDQTLQCGGFESFSPTEDVLNNAEKSCSSNANELHLNPSMSTVEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9W9</accession>
    <name>A0A084V9W9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002100-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00000152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523906">
        <property type="protein sequence ID" value="KFB34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9W9"/>
    <dbReference type="STRING" id="74873.A0A084V9W9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000152-RA">
        <property type="protein sequence ID" value="ASIC000152-PA"/>
        <property type="gene ID" value="ASIC000152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008172"/>
    <dbReference type="OMA" id="AFQGPWA"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="3">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="2">
        <location>
            <begin position="321"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="840" mass="94660" checksum="C9F4F1DFD175E756" modified="2014-10-29" version="1">MATEEENGTFIESFCLKTRNPDRMVRQRALKDFEANYLATVSSSECARIFDETYLDILRCYSDRFESVRILAVTTIDTLLEKLPANEYYLGYIVPVLAKRIGRAEIVEESEELRLQLLEQLARLVEKYSDCDGQRGDPLLKVFDDIVDIMIKTLRDPFPAAQKKSCEIVLAMAGATPSLHYRAEALVAPTKTVLGHRHAANRIVAVEALGELSLHILTNGDRVSEIIMAISPLLMDDVPFVRRACGRAGCLMLLKLRDRYSFFHRILPLVLNCLTDDTAEVRNDIEQRWQEAGELYYKENETELAKVALIEKLPVGYPVDRYTRPTLACRAIVQRSLRVVNLVLHEMEEWKEDIRLHATKLLKQIVLHSERAFSTQFLEVNPVLAKTCMDSEKTIVTEALNVCELMGILLDYETWSKHVLAEFRKFPSIGQLRCMRTLYTHSVQCEEKRNDIKKFAALLLDPDVCHNLKETYQQELLEFCSVLASDGQKRELSAALEEISVSEQETVENQSLERTLYTVILKVVAFCYEEKELIREKGLEVLRLLDNDIDKLHAHHLASVLGSIEHLESVNSDASTNILLLCGIVSVCGFQESYFDTLRVTLAKALTNASPEGKVKLFSAISVAMLTWEEKNKQSKEVQVALLKPFVDELIAPSLVWSAGRSAESIRAMATACFASMAQGVTAEVYMPLLSGYLNVLAGLIDDNNIATRAYTLKALVRLDQGLDLELLKLIAFPILSRLDDPSSEVRELAAICLGRLKLSKACTGSGDGTEPVDSASQRWEDILKQILPVMFLHLENPEIKLRKAISASLQRLYLDNRELMTSLAKLSNVTEDNFVGSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAX7</accession>
    <name>A0A084VAX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001026</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004740">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524237">
        <property type="protein sequence ID" value="KFB35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001026-RA">
        <property type="protein sequence ID" value="ASIC001026-PA"/>
        <property type="gene ID" value="ASIC001026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001026"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8958" checksum="AFFEA8B9519392DC" modified="2014-10-29" version="1">MILTIHHPYDGHAKRLSASYLFVCIRVCVRAFLPRRTKEMIFLTPPDRWKSLLAGREKPFAPSAHRSYERTSERSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBI2</accession>
    <name>A0A084VBI2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00001633</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Rapidly hydrolyzes choline released into the synapse.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01007054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524393">
        <property type="protein sequence ID" value="KFB35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBI2"/>
    <dbReference type="STRING" id="74873.A0A084VBI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001633-RA">
        <property type="protein sequence ID" value="ASIC001633-PA"/>
        <property type="gene ID" value="ASIC001633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001633"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006877"/>
    <dbReference type="OMA" id="THPFCIS"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="13">
        <location>
            <begin position="147"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="385" mass="40890" checksum="F4BDBE8367BD98E3" modified="2014-10-29" version="1">MEIRGLLMGRLRLGGRQVAPLLSLCTLALLAPSLLVPVVHGRHHELNNGAGSLGSHQLSAAGGVGGVGLSSSQPADSISGAAVAGAEEDVGRIAALSKDAGHGESVRIIDPELGTLEREHVHGGATPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGFTAEAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAPRPRPKNAAVMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQNLALRWVRDNIHKFGGDPARVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBV2</accession>
    <name>A0A084VBV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002148</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01009555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524536">
        <property type="protein sequence ID" value="KFB35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002148-RA">
        <property type="protein sequence ID" value="ASIC002148-PA"/>
        <property type="gene ID" value="ASIC002148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002148"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="282" mass="31456" checksum="5179F4B00EF7C4FF" modified="2014-10-29" version="1">MGQKKRAEEGKSTVQPAVSTVSRGGGIGAKGNMESMEEEEDVCFLAAGTEKKTKNNRSRHNMRIIRRTNKEREEEIDWVERKATERVWKVDGTSLAQYQHDVAKTIQKEIFENKQRGDMKEAERQTIAQGKEEKATKSRRRSGDRHAAGSETRIPSAIWRCVSSLLGGAPGEGGGLERGIMNESIAGKRKRGSADKRKGGKDGKINRLQYRESTRSSRGVVKKKPIGSDPDAMDFPSTLHLVYTDAIVAVQERNGPEREPVSRGGGRGGWKKRKVTKRQIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC08</accession>
    <name>A0A084VC08_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00002294</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="ATLV01009969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524560">
        <property type="protein sequence ID" value="KFB35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC08"/>
    <dbReference type="STRING" id="74873.A0A084VC08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002294-RA">
        <property type="protein sequence ID" value="ASIC002294-PA"/>
        <property type="gene ID" value="ASIC002294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002294"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023337"/>
    <dbReference type="OMA" id="NAMELFA"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="446" mass="51430" checksum="D8E69C677EF05D32" modified="2014-10-29" version="1">MAKRNVWSGEETMELLEIIKEKNAMELFANSARGKNEMNVYKMLEDEMKRNGFDGKDASQIYHKWKNLKRSFYQTKKMNKGRATCEFSEELAEILDQTYHPKKEAPVKRRSNNQSKTVRSQIISKLTKVQVENSEEFAKKYNELYDYEFKLYKRKEKEQVALFNQMIEQSKATLIERCRQIFLTPVVDESTDVVDDSNVVEIETTQINIESSEMAAKEPSPIVKAYLILYNGAQVLGWSYMLYQLLAYYTVDKGTDKTLWDYLGFTVILFQNAALLEIVHAFTRIVPSNPVITTFQVLSRVMVVCGVVMATPTGKVSPGLPLAILAWSITEIIRYGYYALNLVDAVPQLLIFLRYTTFIALYPIGVTGELLCFYWAQSHVAETKQWSVEMPNKYNFTFSYFYLLWMVMLLYIPLFPQLYLHMFAQRKKILGAAPSGGAASAKQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC48</accession>
    <name>A0A084VC48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP001348-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00002370</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010369">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524580">
        <property type="protein sequence ID" value="KFB35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC48"/>
    <dbReference type="STRING" id="74873.A0A084VC48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002370-RA">
        <property type="protein sequence ID" value="ASIC002370-PA"/>
        <property type="gene ID" value="ASIC002370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002370"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014807"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017452"/>
    <dbReference type="OMA" id="PRLYAAH"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07164">
        <property type="entry name" value="NR_DBD_PNR_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000058">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="172"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002370-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="370" mass="40024" checksum="40E93F7A8E53AAA3" modified="2014-10-29" version="1">MNDISSMQKMGGGGGPGVLCKVCGDRASGKHYGVPSCDGCRGFFKRSIRRNLEYVCKEGGKCVVDVSRRNQCQACRFAKCLQANMRREAVQHERAPRNCAGPLAAVNALSAHGDYYASRASFSLPQTNLFFPLPLHITASATGGGFAPLSESGRSILSLSSAKENEVSSTGEEVPGGSPTGRAREGTEPTTAAFVKSETDMLLESAAKLLFLAVKWAKTVPSFLQLPASDQKVLLEEAWAELFVITAAQWGLPIDNEFIARNPLAVKLQSAIQQFGAARIDYREAACLKALVLFRPDQPRLYAAHEVLLLQDQTVALLHEKCGGVRLGHLLLLLPAIKAAANPKVLQEMLFRKTVGEVAIERLLLDLMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCD2</accession>
    <name>A0A084VCD2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4 14">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00002486</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 14"/>
    <dbReference type="EMBL" id="ATLV01010660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524596">
        <property type="protein sequence ID" value="KFB35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCD2"/>
    <dbReference type="STRING" id="74873.A0A084VCD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002486-RA">
        <property type="protein sequence ID" value="ASIC002486-PA"/>
        <property type="gene ID" value="ASIC002486"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002486"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013376"/>
    <dbReference type="OMA" id="AKQTCLG"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF69">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="16">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002486-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="29965" checksum="78CFB65A75C0EE97" modified="2014-10-29" version="1">MSTKRDLSCEAVGFIGGGNMAIAIASGLLNKGVLQPEQIYVSATNLANLQSRWSPLGVTHTTTDNLEVLSKASIVFICVKPQILPRLKDVFASAKNLPNCERKLIVSILAGVTLARLHTDLSVLLPTTFVRTMPNTPMQVGVGCTVFCQAADSSSYTEPLYEDLKYMLGTLGLAFEVQESQINAVTGLAGCGPAYVYEFIEALADGGVKQGIPRAMALQLAAQTVMGAAKTVLDTGKHPAVLKDEVCSPGGATIHGVHALEQGSMRGTVMNAVEKATKRASELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCH1</accession>
    <name>A0A084VCH1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP008661-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002549</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01010732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524607">
        <property type="protein sequence ID" value="KFB35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCH1"/>
    <dbReference type="STRING" id="74873.A0A084VCH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002549-RA">
        <property type="protein sequence ID" value="ASIC002549-PA"/>
        <property type="gene ID" value="ASIC002549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023287"/>
    <dbReference type="OrthoDB" id="75950at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="24107" checksum="3431EE04235B145B" modified="2014-10-29" version="1">MSCADQAYDYELEQKRERLRTLLQSEEELLDREIMQKIQEEEASRLRAKQNALLTAKQDQERQRAEFVKNKMIQLKLNNCDEIRCFIQQKYHEESKKCQLAQIEDKMKLKQAKMDEERMWMDVHVRKYKMDLEKELSEKRERKILEQKTLQNIQNQIKEKSLRAAQEKIDLQKLVCASLPFPDYDPKLKVMDKIDLAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCZ5</accession>
    <name>A0A084VCZ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002771</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011039">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524635">
        <property type="protein sequence ID" value="KFB35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCZ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002771-RA">
        <property type="protein sequence ID" value="ASIC002771-PA"/>
        <property type="gene ID" value="ASIC002771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002771"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13523" checksum="E72BC43B49D408F3" modified="2014-10-29" version="1">MDGGARDRPCRIRSRQRLRCPATSGHGRDGPWGRERTLRCGASEQTLVRARPQGGWKCVCAFVCALVDGVCEKGGQLRRCGGRSDTSHRMVHQWKSTALFECPNVPDGFQELHFSRHFPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEV6</accession>
    <name>A0A084VEV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP011039-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00003640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524781">
        <property type="protein sequence ID" value="KFB36500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEV6"/>
    <dbReference type="STRING" id="74873.A0A084VEV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003640-RA">
        <property type="protein sequence ID" value="ASIC003640-PA"/>
        <property type="gene ID" value="ASIC003640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003640"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011394"/>
    <dbReference type="OMA" id="IGFVKFQ"/>
    <dbReference type="OrthoDB" id="78437at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12366">
        <property type="entry name" value="RRM1_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034203">
        <property type="entry name" value="RBM45_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF6">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003640-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="31328" checksum="1F90AA214ACB456F" modified="2014-10-29" version="1">MTNEQPTVPDLNSPPFSRLFVLCGRQVTAAALEECFSPYGTVEQCHIVQDQSTGQSKGIGFVKFQKTSQAARALKEADGKYIEPEPKPIRVEIATSTIESKPLDCLRLKVKCPAELDADAVKAEFSKISAVNSVQLVPDKKSPGNNVAYLTFESFLDAALAYETAKPEHRAKFAKIKPRKVSLESQPQEAKAFFRPFTRRRSSALLPPTKLTVLCSSTLTQNQIWRLFDIIPGLVNCSISHDGGSMGTATVTYNNSQSAKYARDKLHKFEYPIGEKIVVRDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF31</accession>
    <name>A0A084VF31_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00003768</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084VF31"/>
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        <property type="protein sequence ID" value="ASIC003768-PA"/>
        <property type="gene ID" value="ASIC003768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003768"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021733"/>
    <dbReference type="OMA" id="APNDIMM"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36575.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="620" mass="69251" checksum="ABD361FF63B3D4FB" modified="2014-10-29" version="1">MSSWEDVHAVKVKRNSLREKLEKRKKERQDLLGNNSPSGTGGVVGLIKLEAGSSLGDDKGKHLLTTIKREHGGSADIDAEVEKCLVQVLADQSLILPTNSAQITERVERSIQKPVQRDSIAYYLHKLAGQNLVNIKEVSIGGTVGYEVISVEHTNLQALHNDMGMNHVRMASEDRETGGRSEKRRAPRETNRARWPAVPASDIMSLLSLPSTREKQSKKVGEEILELLSKPTAKERSLAEKFKSQGGAQVMEFCPHGTRVECMRSIEATNEAAAAEEQKRKDASEEADKDTDDEVTIISTEADACKNGVLEVKKEPESGGVPVQAVKVKYQCNKLHFKKIIQNHTDETLGDCSFLNTCFHMDTCKYVHYEVDTVVGQAPSSVPAKCEPTDERTVGQKRPNTDPCATLYPPQWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRQLGVPALQDDGLIFLWVTGRAMELGRECLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPPNLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIRLVDPELISSFQKRYPDGNCMTPGKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFJ1</accession>
    <name>A0A084VFJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003889</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC003889-RA">
        <property type="protein sequence ID" value="ASIC003889-PA"/>
        <property type="gene ID" value="ASIC003889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003889"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003889-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="7981" checksum="E34CD91D1C524679" modified="2014-10-29" version="1">MAAEKKITNNNKSGKNCPITGRSPNAVRDCAIVPATAAHTATFLRSTILRGRPGQMDTAGQRRERDRANMAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFS4</accession>
    <name>A0A084VFS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000356-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003981</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012459">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFS4"/>
    <dbReference type="STRING" id="74873.A0A084VFS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003981-RA">
        <property type="protein sequence ID" value="ASIC003981-PA"/>
        <property type="gene ID" value="ASIC003981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003981"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003575"/>
    <dbReference type="OrthoDB" id="10577518at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783330" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="15052" checksum="B29B9F46ACF5195D" modified="2014-10-29" version="1">MRNLVACVIVVAHWFNIYAVKCALNDFNEGRTTTVDGHDFQATSTQALFEEYTQTEATTTAFDTTSELTWSTDSQLNATSYTDDPEWTTANLYDTYCRPDLCLRYDRFGQLVSKKHVACGFNGSFSDTCHQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG29</accession>
    <name>A0A084VG29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004094</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG29"/>
    <dbReference type="STRING" id="74873.A0A084VG29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004094-RA">
        <property type="protein sequence ID" value="ASIC004094-PA"/>
        <property type="gene ID" value="ASIC004094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004094"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022837"/>
    <dbReference type="OMA" id="LCAFNMI"/>
    <dbReference type="OrthoDB" id="10051975at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="851"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123154" checksum="2952D2F9A3A2174C" modified="2014-10-29" version="1">MMMPSPAGEGECGVGDACGGGSSESSNSPGASSSSNSSLASSSSSSSSSSSMAGGASSPIAAQVVYMPVGLANIKEELPEPEIQADSELSLDEGHALAQVLEDIPNDEAPPPEPEVQIRAGKVDDSFRKITSDGGYGAKAVMHHVQLGKVAYQLPDQLLKAGALAALHNPHLLSKDQLEKMITEKDPELEYRKHHNNNSTWQRYMPMFYKGIKQNYVRCLECGWLVLHKASTGTGSLLRHRCKIKLPSGVEVKLEPKVSSNWNSGGGQGKTTAKSAAAIAGVQATVPSQAHKYPQPASILPQNVKDDLIRQQACVLYKDIVSADLFELPSFRTLAQMLVNIGVYYGQQENLLASREVLLDTILPAMYHEAKGQLNKVLADCDLTFSFSLFRNALERRSYVAINAYTVASDYYFRQINVKTLEVTGQEGSYVEHLQRIIEDSLARTFTDPIKVVFGGMPLDSSDEALRESAERTLLCHPGQYETIPCVVTMLWNIMKMALGAYGCDSTRYFERVFYQTPDDDETPLSPEVAALYRYLDAFREPIRSLISDTSVTISEVILWRKKLELTLRPDDADTEAEVRTVKSYLLHELREHFLLHNYHRIAVFLDPKFKGLRFLSDEEREETIAAVKAHLHSDLEGIERVKSQYSAGEGGGGGGASVGPNGTKKRTNGSLAPTELKFYEFMDSSLKLECDDVVDDEIKQYIDVKLESAVDIMSYWRTETAFPLLKRLCRRILNIPAACDEMKLLFGQTGQRDVQKRRLMLSEREMDMVMYLHQNSPSRDRFLESSQQIEALVERFARETPIPEAPINPIGSGKIPLAYGKPGELKVWGVLYLRLLAATFSCGYAGMKALFLRLLALPATMGLLWMFYSQTGDDSHGFFSKSGLIMNVLGLSYGVGIWTTITLFPPWRKRFCQEYAEGLYTGATMLIAYNTVSIPFSFISSAVAACVLYPLVLDPSAPDGMTFMYLLVAIWTCFMLAEQLCIMFLLVMKSQLNAAIAASYILIICLTLGSGTIRSTKGLLGWMQDNAKGVHTKYASSLLHTASFLGRKMNCTPANGVVCPLPADFLMERIGHSSAQETTDIAASIAFALGLCAFNMILYLLPMPRFVKRKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH63</accession>
    <name>A0A084VH63_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004624</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013145">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH63"/>
    <dbReference type="STRING" id="74873.A0A084VH63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004624-RA">
        <property type="protein sequence ID" value="ASIC004624-PA"/>
        <property type="gene ID" value="ASIC004624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004624"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000521"/>
    <dbReference type="OMA" id="FRHIETH"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_eS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_eS6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="840"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004624-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114323" checksum="F3724AAAC2EF658A" modified="2014-10-29" version="1">MGKSKKRPRPTSPTTNDSPGKKIKPTTHDPPESATVETAQSSLATEVKQSEEELNARVREWIEAREDGEATLPPPEDESDAEDEDEARINQLWVESITGSFKHQLLKMSEEEKRKSFKYECEWKECSFMTGKDHRYFRHIETHAAEVQIEGDLFKCRWDLCSFSTTKQSIFDAHVHVHGYHTKLKVHGASLSRLANLPKCGYDSRTRNDISKISLSYTCEWPKCGETFDKIMQFIYHVVYHYSDQLPRGKKSTKETISCLWPLCDGSFTHLSHCLKHLRKHTQQREVACFNCGALFFERTIYRNHCLRQVDLRYRKFKCDECDKYFTTERLLKNHADHHVLHVPCPKCPGRFPTPSAMTNHLRRVHLKMRPMECTQCEYRAYGAAELKKHMNRHSAKRLFRCDEFGCNATFRCENTLKIVSPVPYTTHIIKHYNLPPPHYACHLCEAGYASGWLLSKHLNFEHEVKPKPGTFRYRYRVDPDDGFYKLDVYFAKKKQEQERARREGSDWSEDDDDDDDNDGNTEQNIKPAEAKTTINEIKMIGEHAIAIELGMELSKEGNTDQTEEQTTVTDGVTIKKENVSPLKNKEKPGTAELKEDKKTNKSKKVQEFTLNVSFPATGAQKTFDIPSDDHSLRFFFDKRMGAEVLADPLGEEWKGYVLKIAGGNDKQGFPMKQGVLTNTRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDQNLSALALIIVRKGEKDIPGLTDTHVLRRLGPKRANNIRKLYNLTKEDDVRQFVVKRPLPAKEGKKPRHKAPKIQRLITPVVLQRKRHRLLVKKRRTEARREAEAEYSRILTLRRRQERVRRRSRLSSMRDSRSSLTSEKDKKELAAAKKKEAAAKKEATKKDAAEPKKDAGKKDAGKKDSAKKDSTKKDAAGKKDVKKDAAGKKEAKKPAAAAAGGKKEGAKPDAKKGDKKPAPKTEGKKTAASADKKPAKDAPAASKKEAPKRKPEAAPKGEASAAKKEKKQQPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHF6</accession>
    <name>A0A084VHF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002005-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHF6"/>
    <dbReference type="STRING" id="74873.A0A084VHF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004699-RA">
        <property type="protein sequence ID" value="ASIC004699-PA"/>
        <property type="gene ID" value="ASIC004699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004699"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000812"/>
    <dbReference type="OMA" id="RKEYSHD"/>
    <dbReference type="OrthoDB" id="7738694at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783638" evidence="2">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="449" mass="52173" checksum="C092CC823BA681A4" modified="2014-10-29" version="1">MRHLQLLLFGTVLFVLALVAFGEPIHSHHHNHHLLHHKKKHNHHHHHHKGVYGFGDPFASNGRWLPEEDATCNCGLLMQKIKRLREKVMTVLNKFDKLLKVQVDLRQIKNLLKNIDLSLTTLGGFLASSESQLDVLGEQTWLISVAFSRAKAGAVQLITKENLVDYLGSVKSSTESPTLEELEEITYPSCQDKRIVKTGVYKISVNVTKSMYVLCSLDFGNNAWTVIQNRFDGTENFFRPWNHYKQGFGYYGYGEYWLGLENIHSMMAGREHELLILLEDFDGKFAYAKYKYFRVDSEKDGYKLSKLHHYVGTAGNSLQDSEGMMFSTYDRDNDKSDENCAERNHGAWWYKACGDTNLNGAYRKEYSHDQSGLFWKEFRGVNYSLKRTRIMIRSRKDHHHHHHHRQQGWDPHKGYHRLEGEYDAADEFVEDETIDDDDDFVPTSFEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHN7</accession>
    <name>A0A084VHN7_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Multidrug resistance-like ATP-binding protein MdlB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004702</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHN7"/>
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        <property type="protein sequence ID" value="ASIC004702-PA"/>
        <property type="gene ID" value="ASIC004702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004702"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8088" checksum="2437E25B95A127A8" modified="2014-10-29" version="1">MAAGLDIAPSGLRRSLHPNKGSCKKNVCEGTDTKIKRHHFPTTRLGERLENPHPVDIGEEERQSLEPSIFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJZ8</accession>
    <name>A0A084VJZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005635</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524925">
        <property type="protein sequence ID" value="KFB38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005635-RA">
        <property type="protein sequence ID" value="ASIC005635-PA"/>
        <property type="gene ID" value="ASIC005635"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005635"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005635-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7391" checksum="DD36A0657F3196DB" modified="2014-10-29" version="1">MECIVDDSSPFGVHKPQTRASLSFQNLCHRRASLPFQPQFHPWRKVNERRNSMPTLARGRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK18</accession>
    <name>A0A084VK18_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Sidestep protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005659</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524931">
        <property type="protein sequence ID" value="KFB38312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK18"/>
    <dbReference type="STRING" id="74873.A0A084VK18"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005659-RA">
        <property type="protein sequence ID" value="ASIC005659-PA"/>
        <property type="gene ID" value="ASIC005659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005659"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005249"/>
    <dbReference type="OMA" id="NIACVEG"/>
    <dbReference type="OrthoDB" id="6431884at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF28">
        <property type="entry name" value="SIDESTEP IV, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="39186" checksum="846C51F929ED4441" modified="2014-10-29" version="1">MPIVTLKMGSSLNPDDIKEGDDIYFDCHIQSNPKPYKLAWYHNGNELHHNVTAGIILSDHSLALQGVSRSLAGDYTCMAANTEGRGTSNHVTLRVRYAPVCATDREELLGALKHETLQLKCEVDASPPAESFHWTFNSSGEQTELPSRLHSSETGLSRLNYTPTSDLDYGTISCWGRNAIGVQKSPCVFQVVAAGRPFALQNCSVSNQSADSLHIECIEGFDGGLPQMFLLELVEVPVLRLVRNLSLQHPPVQFFIDNLEPGSSYRIILFAANAKGRSEPVIIDDITFKGVARQLTGKYSLGSQAKKETRAHRTSRNQSISRSKEGCLYYPLLYLFWRNQPHLTVSHTRKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKJ1</accession>
    <name>A0A084VKJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Kelch-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005890</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014226">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005890-RA">
        <property type="protein sequence ID" value="ASIC005890-PA"/>
        <property type="gene ID" value="ASIC005890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005890"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005890-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10460" checksum="ECF72D864E7BCB8E" modified="2014-10-29" version="1">MPLKLTVINLDNFDPCLPPSSVSSTGPKPRPINLRTSGCRLRDCVSLTPSDGRSARRRRPVWIGGYDRAQSRVTLTTTEQQTEFPRPARHRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLF9</accession>
    <name>A0A084VLF9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 H</fullName>
            <ecNumber evidence="8">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00006286</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01014489">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLF9"/>
    <dbReference type="STRING" id="74873.A0A084VLF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006286-RA">
        <property type="protein sequence ID" value="ASIC006286-PA"/>
        <property type="gene ID" value="ASIC006286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006286"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018128"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006286-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20613" checksum="EC04DA4EFF71B34A" modified="2014-10-29" version="1">MSSPSAGKRRMDTDVIKLIESKHEVTILGGLNEFCVKFFGPSATPYEGGVWKVRVHLPEHYPFKSPSIGFINKIYHPNIDEVSGTVCLDVINQAWTALYDLSNIFESFLPQLLTYPNPVDPLNGDAAAMYLHKPEEYRKKVADYVRRYATEEALREQEPVESSDSESSMSDFSEDEAQDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLI0</accession>
    <name>A0A084VLI0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00006309</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLI0"/>
    <dbReference type="STRING" id="74873.A0A084VLI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006309-RA">
        <property type="protein sequence ID" value="ASIC006309-PA"/>
        <property type="gene ID" value="ASIC006309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006309"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016751"/>
    <dbReference type="OMA" id="VMHQHWG"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000017">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB38824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="18343" checksum="92146A65DE873A6C" modified="2014-10-29" version="1">MANCILRRACSKPALVFARSLALGNATSKTALFSGSLLAPPHKQQILTSAVRQFAVSPVRNSSGGSHVTLWNAERALSLALLGVVPVGLMFPSQVGDTLMAVSIVMHQHWGLEAIVTDYVRPILFGTTVPKLAHGLLLVVSAATLGGLFYFNYNDIGIAGCVRKIWTTKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLY4</accession>
    <name>A0A084VLY4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLY4"/>
    <dbReference type="STRING" id="74873.A0A084VLY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006527-RA">
        <property type="protein sequence ID" value="ASIC006527-PA"/>
        <property type="gene ID" value="ASIC006527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006527"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002883"/>
    <dbReference type="OMA" id="KGQFDMK"/>
    <dbReference type="OrthoDB" id="8179031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25744" checksum="0F137E6D6F788889" modified="2014-10-29" version="1">MHPSATTIKVCSRNDPELSRCVIESVNDLKPRLATGKISDDFKIPPLEPLALSTVNMDRGAEFKATFSELLVSGPSKFKVDNLKVNIEKLIFDFNIFLPKLSFKGKYDLKIKLLLLNIAGVGDLTGVIENNQARVKLLCENYTKDGKEYIRVKKLLVRIQIEKGRFDMKDLFRGDPVLSQAGNQFINENSRLFLDELTPGLERSLSETFKNTANEIMQQATFDEIFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQS8</accession>
    <name>A0A084VQS8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007811</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007811-RA">
        <property type="protein sequence ID" value="ASIC007811-PA"/>
        <property type="gene ID" value="ASIC007811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007811"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9158" checksum="13B09F3064DE2FC0" modified="2014-10-29" version="1">MRECHGKGGAKVDGKLHWADEDATQQASERKRASFQRAATERNPVCNDSDRPTDRPTDVKPTPTPRSRDGGAGSFVQYTVRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRC0</accession>
    <name>A0A084VRC0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate synthase</fullName>
            <ecNumber evidence="4">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00008007</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the argininosuccinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01015601">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRC0"/>
    <dbReference type="STRING" id="74873.A0A084VRC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008007-RA">
        <property type="protein sequence ID" value="ASIC008007-PA"/>
        <property type="gene ID" value="ASIC008007"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008007"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000724"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="16">
        <location>
            <begin position="178"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB40514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008007-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="424" mass="47763" checksum="AB3D81CB2127EF6C" modified="2014-10-29" version="1">MSKEKVLLAYSGGLDTSCILKWLLEQEYEVICFMADVGQTEDFAAAREKALRIGASDVVVKDMKDFFVEKFVWPAVQMGLIYEDRYLLGTSLARPCISKGLIDVAVQRGCSFISHGATGKGNDQIRFELSCYALNPSIRVLAPWRMDTFCQRFQGRSDLLEYAKRSNIPVSATPKAPWSMDANIMHISYESGILEDPSVAAPEEIYQLTQSPTRAPDTPSVAEIVFKAGLPVRVTELVSGRTMEKPLDILAFLNKAGGEHGVGRIDIVENRYIGLKSRGVYETPGVTILHCAHRDLEIYCLDREVLRVKKYLADRMADYVYNGYWYAPEAEYVRKCILESQKNVSGKVVVEMYKGNVMVTSRESINSVYNQELASMEVHGNFTPYSATGFIEINAVRLREHHRVFGTANMTKHFSRTDSDMKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRE5</accession>
    <name>A0A084VRE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003033-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRE5"/>
    <dbReference type="STRING" id="74873.A0A084VRE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008034-RA">
        <property type="protein sequence ID" value="ASIC008034-PA"/>
        <property type="gene ID" value="ASIC008034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008034"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006787"/>
    <dbReference type="OMA" id="IISNYPH"/>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130125" checksum="C1D65DD256674BC4" modified="2014-10-29" version="1">MNFAPVTAKAFNAMQNLDIAQLATCSQQEIRPLLPCLVRMSLLSPLDNTKSWAEARKQILSLLVGIEVVNNIVSLLQVNYHELEIDVKKEQQIRQKIGYTTQDSAQFHSLPNGIVMGFERADGTNKVRVVLSELFYLQAQINELAAQASLQKSSSSELTIRPSELFDNEIYLEEIADIICIALAELPSLLNLQEVIETLLYVRNGCKIVCWIVANMPDCFREVVTALITNSDEDTTDGKVKLAALYELSEMNPSQALSMRTICVETVKMPSLMIKLSLKDPQNLVAFVSGLLLGNDLNIRSSFALYIRTSQKRKGDVLHQLREDLLKQLQNSILQSVNGSLPEELVVQAAAILRLYCALRGVSGIKFFDEEIQLLMQLITSKPPPTPAGIRFVSLGLCMLIACPSLIAHQSHEAKMIEWIQWLIKEEAYFENVSEVSASFGEMLLLMAIHFHGNQLTHICELACATLGMKFSLRPNTITRMKLIFTQEIFTEQVVAAHAVKVPVTPNLNATIPGYLPVHCIHQLLKSRAFSKHKVPIKSWIYRQICNSVTPMHPVLPALIEVYVSSIILPNQKAGMQQEQHTHKALSEQEIQQVFQNAAGLWNKDLHNGKSVPAATATGGNVEKVKKDHSARNETIELDDTGNRQPNLTPQLLLLYYLLLYEDVRLSCMPQIIVSGRHVKSYSNEFMSELPIKYLLQQAQKNQHEYSALFSPLLRLLVTHFPHLSLVDDWIDEELIPFNDSSTGLFIGELTIVEAFEEIELNPARVIKLLRRMMRKSPTDLWPLAPTFIRYFKHTLNHTVPLLLQELYRQVWMRLNTIFPRRLWVMSINALMPSDAVTKNFTLTQENILLDPLQVLRCDERVFRCSNALTIVLRILQAILAASRSQLSRHMLDKPLIDVSGNQVKADNDREELKLALIASQESVGVQILLEACLEKEKDRTMPGRQWALREVRGVICSYIHQVFIAEPSLAKLVHFQGYPRELLAMTVRGIPSMHICLDFIPELLSMAEMDKQIFAIDLASHLSLQYALPKSLSIAKLCVNTLTTLLGVLSGDTRIEMFRAVLPCIVRFAEAFPPLLDECILFLLQLGRIVQSQSALGRSTSLPSLFVGQDCKVRSQSRRLQHAEKLVDEVRDTFAKLLDVAVLSPKIYSHSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS89</accession>
    <name>A0A084VS89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP001320-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008353</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525039">
        <property type="protein sequence ID" value="KFB40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS89"/>
    <dbReference type="STRING" id="74873.A0A084VS89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008353-RA">
        <property type="protein sequence ID" value="ASIC008353-PA"/>
        <property type="gene ID" value="ASIC008353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008353"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012451"/>
    <dbReference type="OMA" id="MMECLIE"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783971" evidence="11">
        <location>
            <begin position="27"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="392"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="530"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="718"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="901"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="967"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125735" checksum="378DCB139A1B283E" modified="2014-10-29" version="1">MIPENAASTFGLLLVTLSVLIVPSRSAEITASVTKLIDEEACSQLKTLCPKITPAAEDLKALECVQSLLPEQLDTIGPECQHLIWLHTSALMDDANLKRMIQKGCPKDFQQFPCSASEEPGQYLTCIINHRSIAKGNGCIGYIQRLEWVAFSDYRFIKQFLTHCTRDIEALGCGRVAAGNDREKVSQGETIGCLQNSLDSVNQECKREVLHLSEVQSEDFKLDRQLYVACSNDAFRFCQSNGPGGPPTLLKCLMKHRNDPEMSKNCQQQLLRRDKLVVHDYKVSRGLTRACKEDIKTYRCRRGVSDDKDVRLAQILLCLEAVQKNSTKLMPECVAEINDHRKMLLTDYKLSPEILTGCENDIEKFCSNLDAGGKTIHCLMEHARLKKKKERRVTDTCLRALETLVKVTDVGEDWRVDPVLRKACKPVVDVACSEADGGDARVMSCLMEKLGTNYMNVECESALLQIQYFVARDFKLDPQLYRNCKDDAIRFCKAKKTWADLDTAQMDPERGPLILPCLHRYAYPEKEELRLKPECLQEVKRVMRQRAKSVDLIPEVEDQCLDDLAYFCFDKTGKGEEMQCLQDNLEKLQENCKTAVAQYTEEEAAHVELNPIIMSVCGAAMEKHCANILKTGRDEGDMMECLIGAKNDPDMREDVKCRAAIEHFQIISLKSFHFTYKFKEACRLHVARFCSKCTTKYEVVTCLSEVMRNDTIKEAKHSIPKECRQQVRAQLYQQRENIDFDPKLKAACKEDIARHCPQIPHGSGQVLECLQTHNGDLTEDCRHQLFSVKKSELTDSATDYTLLNTCKEMIHQYCHDTEPSRMLHCLKLHKDESLFDDRCHLVVVNRMIEQNLDYRFNPTLQMACSKNIAEYCTPIIRSAKQNEELNGKVIDCLKIRFREGKLLPECEKQMTEVLHERALNYKLNPLLQSVCRDEIQVLCSASTDTETNEDHGAVEECLKQAFLEKKLINRACKVEVAELIQEGKADIYADPLLQRACSVDLLKYCSHIQSGNGRLLKCLEEILHGESKALEDDCKNKLLSRMEMFRNAAAFVPPAENFHQLYDQVVASPAKHYLLLVLFSFIGIIFIIGLLCGRVTNRTMALKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSQ0</accession>
    <name>A0A084VSQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Pleiotropic regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008606</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016136">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008606-RA">
        <property type="protein sequence ID" value="ASIC008606-PA"/>
        <property type="gene ID" value="ASIC008606"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008606"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008606-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="32463" checksum="BB6C809286E4A47E" modified="2014-10-29" version="1">MRPILANPPGVRIADPLMRMCDTRNYARLTGTARPVRCGFLHTAYTDGSGSGNQTRPPHFSAAFTREKPHHQSREPAPGPKWELRKASCRRKVEESGTKYSTYNKSSPTGTSVMLPGRTQITQSKEKEKTNPYAGEKRRQKRRSLLISFRSLEIAPLPGRVRVKDGVRSSAPNRSATMCVVSHSRRRWHSSTSKLPGFSDRFTCHGNRNTHHHHRKIYRHHRSLIRAAIVSVQAPSADRRQSAEKETASSHPKLLPQAGEDLATVGTGGLEKVNILNRHPLAGGPPSGRVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTB2</accession>
    <name>A0A084VTB2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008771</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01016287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTB2"/>
    <dbReference type="STRING" id="74873.A0A084VTB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008771-RA">
        <property type="protein sequence ID" value="ASIC008771-PA"/>
        <property type="gene ID" value="ASIC008771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008892"/>
    <dbReference type="OMA" id="SEFTCPH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000069">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="457" mass="48450" checksum="16980B8614DB5315" modified="2014-10-29" version="1">MEALVENTATTPRFYCHTCNIEISSISSEFTCPRCSQGFIEELPALPASSPPPLQDLGQPSGEYGNPLNEASQAIRLAGEIFTNTLLSPFFRNHNDPRDGDEAGASSSAGNGDHAMYTLEDIPIDGGSQPSGPSGAGGPSGLDGGEGAAGGSGSSGAGGVTLFGGDPRPSMRFPGRRGSRRRGMQNINHVDHILREILISVSGGANGGAAGGPMFFMGNPGDYAWGREGIDTIVTQLLNQMDNTGPPPLEKERIAEIPTVTINAEQVERKLQCSVCFEDFVIDESVRKLPCMHVYHDPCIIPWLELHGTCPICRKSLTPEQSQASPQSQSQQTQENSTGTPPEESSEPSQQPQEQRPQPQQLTPSSQNQQGVITFRIRPSMTNMVVEMGPSGVSSSSLPQAGSNVPRMVPTPGSAFTRRPNVPSAGAPSSRGSRTTNEPGNSNRDDDGNIDNTLDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTX1</accession>
    <name>A0A084VTX1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009001</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016526">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525092">
        <property type="protein sequence ID" value="KFB41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTX1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009001-RA">
        <property type="protein sequence ID" value="ASIC009001-PA"/>
        <property type="gene ID" value="ASIC009001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009001"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001790"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016574"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009001-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42385" checksum="13830F639E174BD4" modified="2014-10-29" version="1">MVDRENIYSLADPRQFGNILKPNSIVATYGHTPGDFRRVFTNEMEGICAMTAGLNKTTFFEAFMDPFDRYVWISWLVTSELMLIVWMLIRWKRRRIPSIRNIGQEYVDLHFHLIRFSILSPPNLRNASKLENMLTFCYLVAIFHIVTLYESIVTSNLSTTRYGKVINSIQQLIDLQIPIFGLESTIETLNASRSGFNLDGHGPNQFLATVCSYARLGSHISPNHVHVIREPLLNHYIVYLLHKESILQEVLEKYVALSYQADLYRYWDHFNPSKSIRLETARAELTANVIEFEELMWQFVILPIGCLLGAVTFLLELGWHKIELRWYKQRRNSSPNLFKRARKCPSSQSPSAKRRIGQGNAGNHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU02</accession>
    <name>A0A084VU02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009045</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525097">
        <property type="protein sequence ID" value="KFB41446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009045-RA">
        <property type="protein sequence ID" value="ASIC009045-PA"/>
        <property type="gene ID" value="ASIC009045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009045"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6728" checksum="33EFCF73683FD5A0" modified="2014-10-29" version="1">MYYAIAPSICGNWRLASGTSDNVADRAMITPRSSARMKDGKRQCTLSDDVMNEEVCRVTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU46</accession>
    <name>A0A084VU46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009084</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525098">
        <property type="protein sequence ID" value="KFB41490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009084-RA">
        <property type="protein sequence ID" value="ASIC009084-PA"/>
        <property type="gene ID" value="ASIC009084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009084"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="13631" checksum="0DB295D18EB11213" modified="2014-10-29" version="1">MFGRPMSPKGRKRSLRKNLPWSFGSESLIDQDGPQEREMDRFSNPTWTTHCRRKLMSIDPFRFSSLTIRRESAQSTRHFEPWTSFFFLVRMNMDGSIDQCSVQDHDHDHDHDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUD9</accession>
    <name>A0A084VUD9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP004845-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00009185</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an olfactory role that is not restricted to pheromone sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUD9"/>
    <dbReference type="STRING" id="74873.A0A084VUD9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009185-RA">
        <property type="protein sequence ID" value="ASIC009185-PA"/>
        <property type="gene ID" value="ASIC009185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009185"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009401"/>
    <dbReference type="OMA" id="NPRQEDH"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF50">
        <property type="entry name" value="GH19047P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB41583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009185-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="580" mass="65527" checksum="C4294BE8D5BFA823" modified="2014-10-29" version="1">MPESVALSGPATAVPVAHKPLQKRTSALNTLFFYLGLEKRVHKDDRKTQRLRILTLGVLSIVFVASAIGFYIMWWTNMYNESVLENLILRKNATATEWWAKPPVYPLLKVHIFNYTNTKEFLAGTDAKLKVKDLGPYVYKETAEKRNVVHNTDGTISYRDYRYIQYEPLQSEGKPFDQVVVPNVVFLSAVAKKRSETYFSNMMFNTAAAGLGAAPFMTQPADSFIWGYEDNLLSLAKRFFTDGIDSSTFGMLMSRNGTSAENFTIFSGESSLRDLAIIKQMDGKNRLDLWHTDECDLVGGTDGTQFPPHLMEGKQTLQVFIKSLCRKFPLVYDSEVTALDGIPAWRYKIPTTVFAHPDEHKPNHCFCHLQSGSCPPSGLFNISGCSMGAPIFASFPHFYTGDRELIESIEGIEPVQELHESYADIHPRLAFPIDGASRFQINIQVQKASGITGFEKFKDGQYLPVLWLEVVPGVISEELRSMIYHSTYSANAIQMSLRVASLVFFVLSLVMLLARFYCCSKATSSMKREEQERQFAQVRYEGKDQEPAQVVCENKLEQIKPLDNKPEHNPNTLYPALNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV15</accession>
    <name>A0A084VV15_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009556</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017144">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV15"/>
    <dbReference type="STRING" id="74873.A0A084VV15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009556-RA">
        <property type="protein sequence ID" value="ASIC009556-PA"/>
        <property type="gene ID" value="ASIC009556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009556"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009044"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000876">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CP-type G" evidence="11">
        <location>
            <begin position="27"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="146"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009556-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="318" mass="35842" checksum="7668A76A33C3206A" modified="2014-10-29" version="1">MQSFRATFPSVSRDLLNWFPGHMGKGMKQMQQKLKLVDCVIEVHDARIPLTGRNAEFKYTISGAKPHILVLNKRDLIDKRAEGTIIKRLQQDDYEAKHTLFTNCKSQSCSGLRKLMPLAQDLISGSDRFNRANQREFCIMIIGVPNVGKSSLINVLRNRHLNKKGASQVGAIPGVTRSVLNRIKICEDPPIYLLDTPGILEPNIADAETGLRLALVSCLQDHLVGEELIADYLLFLLNKQQNFRYVQVMGLKEPTDSIANALMESAIYLERTIRTKQLDGTEVIRPDVTMAAKFMIKSFRTGAFGKVLLDEDKIFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV34</accession>
    <name>A0A084VV34_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009667</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV34"/>
    <dbReference type="STRING" id="74873.A0A084VV34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009667-RA">
        <property type="protein sequence ID" value="ASIC009667-PA"/>
        <property type="gene ID" value="ASIC009667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009667"/>
    <dbReference type="OMA" id="CESMIND"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="420" mass="47831" checksum="ADE2B3F52CBB02BB" modified="2014-10-29" version="1">MSTFTGFIPELPGIAIDCFEDAQRSKSSMFFLSHCHADHMRGLERNAPLPGALHLSPISGVFIKHRYPQHADVVRSFNVGEQLALKVHPSTGEPPYELYVRSLSAEHCPGSVMFYFEGNATRVLYTGDFRLSSQKNFTTQSSGIQPAIVYLDSTFLDADYSYFPSREESTARVINLCTEWLAADQRNVVSLWLPANYGSEDLFLRLFDRLKERIHISDKQRAPYMHFSSLNDILTGDSSTRIHACTGTMRSSRNLTCETLCNEDSLSFVRTIRPSALRWRGLQPTEQFWKESNNLFYVCYSAHASCNELGAFLAHFQQHLCDIRLNVIADEDDRVRKEHLLESILGNGINRATNSNGTERRDKVEDGLSLNLNKIEYKTKRRTNHRAGETTESSESEDNDCDLSYRKLPKRSYVEKPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVZ6</accession>
    <name>A0A084VVZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009803</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009803-RA">
        <property type="protein sequence ID" value="ASIC009803-PA"/>
        <property type="gene ID" value="ASIC009803"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009803"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009803-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="6128" checksum="2544B317D899039F" modified="2014-10-29" version="1">MFVNGRSHTGAKNVRLEHRPLPEDEVHRTIPMAIREQQQLQQKQHQQRFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWT2</accession>
    <name>A0A084VWT2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010124</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017753">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010124-RA">
        <property type="protein sequence ID" value="ASIC010124-PA"/>
        <property type="gene ID" value="ASIC010124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010124"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022222"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10378" checksum="132777559735743E" modified="2014-10-29" version="1">MTNEEEPINYALQQARRVTGSDIDRIPSGTLPRGVSALTHFWGLMLTSLSTGHVRHSVDPQKSVRLTVDFVSYGSLIPPFEHRPISSSSGGGCGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY23</accession>
    <name>A0A084VY23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010621-RA">
        <property type="protein sequence ID" value="ASIC010621-PA"/>
        <property type="gene ID" value="ASIC010621"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010621"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010621-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="19359" checksum="2EE30D5F5921F7CF" modified="2014-10-29" version="1">MHGTIGNCGPVCREIDIDRTDECTNRRKNQRVFEPFRGLASGLEARVRRICQANVRTRLLTSGPVINSTGLIVRPPPQEPGLLRVTPQSKSPVHDTVFLCVLFRIHFWFSRSDSPREQQASRGTGGIMFPPTGGTHAHTSEPVEASPGERSGPSARTVVRRFDWFVRFGAHWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY79</accession>
    <name>A0A084VY79_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00010790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018326">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY79"/>
    <dbReference type="STRING" id="74873.A0A084VY79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010790-RA">
        <property type="protein sequence ID" value="ASIC010790-PA"/>
        <property type="gene ID" value="ASIC010790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010790"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008252"/>
    <dbReference type="OMA" id="VQTMYRD"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="9">
        <location>
            <begin position="160"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="833" mass="95373" checksum="9E679542B7DC7DDD" modified="2014-10-29" version="1">MTYRSHNVGPSRAFDHIYDPLYVASDRKDVCRANHAALAKSAPIGIFPVYQSMFSELPRLTRNHYVMHRNPLPYHPEVQVTSLRTYGTGYTAQTPDTSRVLGSERAKFFCHPNSGETGCNVRYAPEHHGGGEQETEYCGCDYDESTGDTGQPRFREVASQTVFRESSAQTQPWMPTAVLKENVMPAAEIVYVAEMLQHTRFPGVNEVEIVERARRKRTWEYALGACDSVDEWRQQKLVLQIFEWEEWVARERQIDRYQMLRLQLVAKIMEKRERDTHQATEGKMENTKRRINEARNQAMQKLEATFERNLRKLERKRHEQSVRHGAKDWRGMGGTGNSLALEPFSGGRKKYTKQSYDYDPNLIEVGLAKLEKKTAVAHKFVNPRDQRPQLWKPKEVCREFQKGFWSDNFLRKLYESLKQFRNRKDTERTAPQCLIVVSSPTESLVVSPVAMSPERENDSLYQQAVLLQKLIRGRATQLMIHRDYASEHDLMEDLIASHRLPVVEEFFPAEGLPAVAGGSVRERYLHILKNEQLLDAFIEGSSHGQMSSLMNTLERELTRLQQERNTQAFYLLAEQERYGRESSSMFESSSAFAPPVDRKSQGAQDELAIYLENALLEQAENIDEMREKIHQLVRKFDEEADRRSDGTSLLSACGPGLGTVGGREELVSIAGSLADEMIVPDLFRRAVRERIKFKQQTCLANVHDMLYNRQEDEETRVTTDGSNVHKAPTTDQKQPEERRVVDGLLEGIIDRAVQLPPAATAESAYSENEVEELPEDEEEMAGSDFYGLRFDGAEMEADEQEEEEEIGRMANDLIEDILSQVLDVSEEDNAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYT5</accession>
    <name>A0A084VYT5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Hemoglobin and hemoglobin-haptoglobin binding protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010898</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525233">
        <property type="protein sequence ID" value="KFB43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010898-RA">
        <property type="protein sequence ID" value="ASIC010898-PA"/>
        <property type="gene ID" value="ASIC010898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010898"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12046" checksum="39D5CA0230349D51" modified="2014-10-29" version="1">MRRAVCFAGLTALPFACRHMPVHVYGSLVSCVPSVQAGACPFFSGRSYNAALNLSNATRVGTVSRKGKRPANRTTHRPPERPNDSRRQWPGTNVPTNKSSNSKPRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZE8</accession>
    <name>A0A084VZE8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001738-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011135</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018748">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZE8"/>
    <dbReference type="STRING" id="74873.A0A084VZE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011135-RA">
        <property type="protein sequence ID" value="ASIC011135-PA"/>
        <property type="gene ID" value="ASIC011135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011135"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017412"/>
    <dbReference type="OMA" id="MWDKSSA"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000008">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="365" mass="40806" checksum="FF4F44F52A76CAC7" modified="2014-10-29" version="1">MLSLTSIGFIRWSTSPLLIGGGRLLHTTSLDLAARKGTREKARKAKVKKVVEKVGFIRHDLRKKGKLNLNVANKHIDDSWKQESKDDCWVSKYYKWRVYSVEEAVHCHRETHHPTVYNLPNAPLFAHVELNMQAEKATRFVDNFQRMVAVPHRFEHGENRNIIVFAKGQEPLKEAKDAGASLVGGMELIKEIQNGDLQLSEYPFVLAHPNILPELVVIRGLLKKNKFPNPRSGTLGVNLAEMIEKYAHGINYAATKDEQQKDFGSIVACIGTLQMDTKHLESNLAALLQDVNTMRPKREGKFVTRVLLKSPPSGENLKIDPFIYIPEEGTLGKKSSKANQLDAGTEEDDEQEEEPKAAAAVGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZM8</accession>
    <name>A0A084VZM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003746-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011234</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018885">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018886">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525252">
        <property type="protein sequence ID" value="KFB43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VZM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011234-RA">
        <property type="protein sequence ID" value="ASIC011234-PA"/>
        <property type="gene ID" value="ASIC011234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011234"/>
    <dbReference type="OMA" id="AFMMHEP"/>
    <dbReference type="OrthoDB" id="6162910at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052660">
        <property type="entry name" value="Erythrocyte_Invasion_ImmMod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021:SF23">
        <property type="entry name" value="FI18411P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021">
        <property type="entry name" value="MANSC DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1316" mass="141413" checksum="ECD47304E8690C8E" modified="2014-10-29" version="1">MFRIKKSKDNNFYFAQSQGRFVPSFENPRNGFFPSALQRQQPPPDSYQEQTLFVNNNNVDRGTGASEGTGSRGITPSYYQFTYTGRFVPSFENPRNGFFPSALQRQQPPPDSYQEQTLFVNNNNVDRGTGASEGTGSRGITPSYYQFTYTTPRSADIFEISPRPFSATPSSNSGFQYSRSPLRSDFFSNGLTPSRTFPATGRQTNAGSQRKSPFGSFSADPSTTEAPQRPPPPAAAPPAPASEPSSVRDRQLSYISNRARPFASEDRGEQSGTPTRATARQQLPRSPAATAVVTGGTRNSYSSSRSRQPDSTQATLSGQRQQTGRDASTGQQNGSRFGGTGTQSNSRTTLRPNRYRSTPTTTTTEAATERTTAAIDSAAVRNRFSGRTPAPNAFRQTFEAKRISATNSAAIAPRGSFVNSISKSKATTTTSTPTTTSTTTTTAKLPVLSRFIHQPAKPIIPSINITHNGSAKSAEVIYDYEDYESESKESTGFGGEKQEINDFQPTSVAKNNSIALGSGVAAEQEKTLPGVSTTVATKNELEDPDGRLNNISENEYYDTVRESGTAPGDSVGVEDHTVILTDNFYLPGGAGGSEETFEEGEEEDGGEELTSLQREINSTAELGVSDPQEKAYDEEYVYEDEEPGVTTTVRTPVKTVPVPPPVTQDDSADMLQFSDEDAKDVEEAQVQEATKETLSDGSPAPPTSNVSTESSTESSASPSTTTERVAPSSSEFEGATNATTESWVVVASVQTSRSVSGARFLPFPQVNQDEKKQPLADLEMKGSNESDDVEATTASGMVNDEQEGVTTVAPQEPVIAVTQDVADSVTTERTILAQSTESIIDKLDRVQSELSSGLFAGKFPVLKDPTVVEDQKVPGSTALPPVVIRKFQPNARATTTKKPRPGLTTTTTTPKPTTSTESLVKKIKFETVDDISALLPPDYKAKAGFKLKKPNAALEATTTTTKETPVEEPARSELVNRFRSANISRSYKSNVPIQELSSLLPKDYKLNRTEEDIRSTNNLKELISKVKVNGADKPNVTLDVLKKVQKVDVSAFLPPGYKPPETTTPASKAPASIEDDVSKFLPPGYKTFKTTKKPTTTPASVTIKDDISKLLPPGYKLPKASPETVTEKPKLVFSDDLSKFLPPGYKPPAEETDAKPVAEVIDPSELLKKIQFKDVSALLPPGFNASKVEEPVATSTAAPANVPTGSRGVVFASRPGVKKPPAPGAAGRSTTAKPAHAAEGPKVPEIHIRKGPPTRATTEFTGWPTPSTTPISIEKLLEQQKQQELLEKLLAASSSSTSTTTSTTTSTTTSTTTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZN4</accession>
    <name>A0A084VZN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011240</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525252">
        <property type="protein sequence ID" value="KFB43428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011240-RA">
        <property type="protein sequence ID" value="ASIC011240-PA"/>
        <property type="gene ID" value="ASIC011240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011240"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011240-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13076" checksum="29FE0165AB33E821" modified="2014-10-29" version="1">MLHPSSVEDTALTAITLRNGSRGHVDATGHPNLSSVGGPVWPKNRSQKPPVPVGRVDVTATRDKPERRVRRCCNSVLLPRAWPQSNGESEAVNGAGGLRLVEQASRKVHKSVVTGGAQARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZR1</accession>
    <name>A0A084VZR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004772-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011303</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018943">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZR1"/>
    <dbReference type="STRING" id="74873.A0A084VZR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011303-RA">
        <property type="protein sequence ID" value="ASIC011303-PA"/>
        <property type="gene ID" value="ASIC011303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011303"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008190"/>
    <dbReference type="OMA" id="ICYETHE"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07656">
        <property type="entry name" value="F-BAR_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000094">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="443"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="722"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126783" checksum="D3C6857F275CAFB9" modified="2014-10-29" version="1">MEAQIALVQELQDFFRRRGEVELDYSKSLDKLAKSLQLRHKEQRQKREQWPMFSSYSCWQQLVNQTKSLSRDHAAMSEIYSTHLVARLQTVWDDVQRIYRKCREIGFETHVEILRILQELHTNMKTYHTLQTEAKEADKKLRAAENQRIKLQQSVPKEKLERSKKYRLIEKEVLKRRNKYTDARLRALKAKNEYQLCLEASNTTIHKYFVEDLSDLIDCMDLGFHSVVSRALLMHVSADQGRCRAVLHNAEALSHIVNLMDSRADKQKFLEQHSAAFRIPKRLEFQGQDEEVEPELQKALHQEMESRLLQLEQRVNNLRMESEEIWKTLETAEINLLDILNTKDYDCTSAFGDGAIAVQKSESISLKLRSDKNEIEEFYITKIREYILATSRIARLDSKAEYLRNALTKDSACKTDTLTKPNVPKRKRIGRINKSGRPKLFGGSLEEYLEVSGEEIPLILRSCIRVINLYGLHHQGIFRVSGSQVEISNFKEAFERGDDPLAEMTDASDINSVAGVLKLYLRELREPLFPLIYFDHFIQLAQLESKQEIVSGIRKFFYSLPKSVVVVIRYLFAFLNHLSEYSEENMMDAYNLAICFGPTLMPAPEDKDQVQYQNQVNELIKNIIVHHADLFQKDLGGMQYEKFITSETFEDMCPMIGGKERGEERDKSEHLKSSSSEESVRKRRPSGNISLNSQLSICTQNSNITCGSEYTTSTISATAGAQNTEPIYAEPTKVSINREKSPATDSGTSSTSNDEESDNVELRASLLGGIGEPPEHSKSTLGLNRRSESMLSSNTPSADDEPPKAMSADDQSDRSKSVRKYHSKSFSLSDNKLVLMGNVGGATPAGTFNVFQQNRDLWQKRATQSSYQSLTTSRILSRNRIAPDLVMDLPPSAITKEGPVHASRESIDNELEDMTSAERFAAQNQCTLKKNERFSNESPVYENNTVKKEVKLDGSSALAVDKPKAEVKPQELSIKSSSNSISSTEVQKIDEEHANKEATMIECGNTSLSAAPLTVAEVEEESPAAETSNPVTHKDVSKSPIPAHNTQKFVSQFADLHLTGGCLVKSSEGIACASVTSLTQEQQAKSLSSFKPQVKVKPQILKKPQVLPPQTPEMQRRNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W131</accession>
    <name>A0A084W131_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00011750</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01019208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W131"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011750-RA">
        <property type="protein sequence ID" value="ASIC011750-PA"/>
        <property type="gene ID" value="ASIC011750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011750"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015987"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019771"/>
    <dbReference type="OMA" id="EGETHQK"/>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="94"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="1395"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="19">
        <location>
            <begin position="1544"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1264"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1322"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1483"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="451"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="564"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="786"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1294"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1323"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1339"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1377"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1483"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB43925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1907" mass="217450" checksum="AE9817549ECEB738" modified="2014-10-29" version="1">MSKQGKKEQLKIAARTARLNNLVVGRTNGGDGKDDSNLEVAISREGLLDSLFVLYDECSKDVIKKKDKNIAEFVSKYRPIIKETRSLRVNVDDFDVKCLIGKGYFGDVHLISERQTGQVYAMKKMRKDIVSSTQVREERDIMASRRSEWITGLQYAFQDSDYLYLVMEYLPGGDLLCLMRRVGIFDEEVAQFYLAEMTAALHAVHEIGYVHRDVKPENILIDRFGHLKLVDFGNATAINEDGSVTSMTPVGTPDYIAPELLQTLATVSRSTNRAKHDVTCDFWSMGIIGYEFVTEETPFHGDNVNETYSKILAHAEGRFAKKLSYPAHASISAHYRDFLDRLVTNVANRMSHAEIVRHPFFSDLHWDRLRYMIPPIIPTVSADDDTSNFEDADKVGGKRKSMVGGGRMPTYNIARMNDFSGHDLRYLGYGYVYEEPDVAGMYRDTDEHMKAARLAAKVKEQDRRLKEHSGEIHRLQREVLERDRKIATMGAHSKILDETKKELESMKDLLKEKTAELAAIRTDNKTLRNSLKIEKEQRQKNDAQIADVVKQTYKKWEKAKQASDQAYERQLAERKTELAAANEKLREVETELVARLDECQHLHASVENYKDLLKKSKEKLMADKESLDRSQQELIATYDAKIAELRGKWKVEKEKRAGMEAEVRELREKLQEQESSVQFVEETKQKLVDNIKRRMTMQLEENNMLREAKQFSDKMSEEMQRKCDNLRNEISKLQEQTIVTATANSSVDSSRRSSLVYEQEFRSANSSLQDVTAIIVERPNIEAQLRNDLIKARESENEQRKRAENLEEVVGRLEKVIDQLKTSGTGSSGAESLLEKQNERLEDKLSAIREQAILDKQSARTANLSLWKLEKELESLRGEKSILTRRMEQADERVTRIRHEKEELEFKMKQQRETIANRDKQIEDLRSDLAGLKDELKKERDLWSSSEKDRLAEKTELIECVAKIQSLEEKLKDSQQKHHQLNDRVRVLSSENGRLGRELHEALDELAEAKEASDDLEQRLAGVTKNFNLLKGACNITEAQLSEMEILLEKESKRNKECAEQMEALRKRLIEKDNEVERVRQELYEERSGKTLSESRSNHLLGEYEELRKKFEELQQQMVDQQRELIEKTSHLFEVQERIELLNHDAENLQKVVANYEQNHFILKEENARILTDLFLAKEHITRQQNEIKEHKNHTEQAMAELEHVKLVLQEQKTFYTERDIKSEATLAQHKKLIDYLQAKVEECNAHSKKKKTLAGLIFGTSSSTERKENVPPNIGTNGGGVGNNVPVESTASYRKLQEELQKERTRTNQLKEQLLRAKTDLIASQGSNNNTSMHKKQQKDDENMQVEKTHREERVPDRSTKDTPVEDTQRRHSSKETGSANKRSTGGANAPGKAHTFDMTIESTSSASKNPAILCAACDRLILAGHPYWKCTDCGLTVHRKCRSSVTSKCGDGGNAGTIVGRESEKANESLDDFAEELGMVDDEQDEEEGGDEDTDVDSLNRLHRPSGRKSPAFSMTSSAEEKAEEDRYVGDLLFKTKRLEPRLFVNDIYEVSEKAVLLGCDTGLYSYHLETSEVVHIRGISNVRSFAVSPVIPKAILIGSEGEYLYQCDLRHLQSRAHASSCLQPKLESFVLDLSIANRTHSERWHIVRMMENIPAGGSLSDAIAIAATSSRIVILKFDVQAGRFKPVRGLDTVLPVSSVLFTKDTAIVGSDKFFEIDLRTYAAEEFLDMSDASLRDIRNCAPLAAFRINSQEFLLCYREVGIFVDDSGWRSRPDNLSWLQDPVEFYYRESCLFIAHADCVQVMYISKSYTKDLACQQSHADDERRAFIGLRESPRLLAPLQFPKTSLYIACECQGADREQEIVLLDGMKALRTVGFSRSLETLSSLATGVGQSQDSLATLGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W224</accession>
    <name>A0A084W224_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00012046</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01019473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W224"/>
    <dbReference type="STRING" id="74873.A0A084W224"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012046-RA">
        <property type="protein sequence ID" value="ASIC012046-PA"/>
        <property type="gene ID" value="ASIC012046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012046"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022649"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045495">
        <property type="term" value="C:pole plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="260"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="404" mass="45657" checksum="E66419AD120745E9" modified="2014-10-29" version="1">MDDNRQEQTNDGPAGMNPDGVIESNWSESVDNFDEMGLREELLRGIYAYGFEKPSAIQQRAIIPCIKGHDVIAQAQSGTGKTATFSIAILQLIQTEIPECQALILAPTRELASQIQKVVISLGDFLKAQCHACIGGTNVRDDMRRLEQGCHIVVGTPGRVHDMISRNVLRPNSIKLFVLDEADEMLSRGFKDQIQDVFQKLPPEVQVILLSATMPADVLEVSRHFMRDPVKILVKKEELTLEGIKQFYVDVKYEEWKIGTLCDLYDTLSITQAVIFCNTRRKVDQLTEQMTEKTFTVSAMHGDMEQRDRDLIMKQFRTGSSRVLITTDLLARGIDVQQVSLVINYDLPTLRENYIHRIGRGGRFGRKGVAINFVTEQDKRVLADIEKHYNTTIEEMPANLADMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2D5</accession>
    <name>A0A084W2D5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012321</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019603">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2D5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012321-RA">
        <property type="protein sequence ID" value="ASIC012321-PA"/>
        <property type="gene ID" value="ASIC012321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012321"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10524" checksum="870975DE66A513D6" modified="2014-10-29" version="1">MRQEPLAISSRVKEEDRAAQNPEHERESDEERRTNGTVTVRLEKETIGVGRFSAPRYTLAKRDAMENSTKHNGTWKQSRFEPLLSVWGIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Q8</accession>
    <name>A0A084W2Q8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012378</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525277">
        <property type="protein sequence ID" value="KFB44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Q8"/>
    <dbReference type="STRING" id="74873.A0A084W2Q8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012378-RA">
        <property type="protein sequence ID" value="ASIC012378-PA"/>
        <property type="gene ID" value="ASIC012378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012378"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011476"/>
    <dbReference type="OMA" id="NFQDDIY"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000003">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="578" mass="61891" checksum="333537886FD9B7BA" modified="2014-10-29" version="1">MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGRIAADHALVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVYHQRRVGLVLWHPSALNVLLTAGSDNLIVVWNVGTGEVLVRMDCHPDTIYSACWNWDGSQLVTTCKDKKIRILNPRNGEVLNEALAHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALGDPIVMVDLDTSNGVMFPLYDPDTNLIYLCGKGDSVIRYFEVTPEQPFVHYINQFQTPDSQRAIGMMPKRGCDVSTCEVARFYRLNNSGLCQVISMTVPRKSELFQEDLYPDTLADEASISAEDWIGGADADPQLISLKGGYVSQAQSTQLTVTKKSNVLDKMAPKAGVGGGGGGGGGPKSALSGPGSAGASANGSPVTVNNGTSGGGSTSPANNGTQQITIGGVSEQQFGELRTKFEEEFRKLKAIIVKHENRIRSLEATVKAMTDRGLTDAVDGGLVPAAPSATSSSPAPPSSLPPSTDDATHQQQNADDGGHYHNTSVGLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2W6</accession>
    <name>A0A084W2W6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP005480-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00012440</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2W6"/>
    <dbReference type="STRING" id="74873.A0A084W2W6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012440-RA">
        <property type="protein sequence ID" value="ASIC012440-PA"/>
        <property type="gene ID" value="ASIC012440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012440"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019755"/>
    <dbReference type="OMA" id="HMMKSHS"/>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="564" mass="65406" checksum="9967DAFAF6D859BA" modified="2014-10-29" version="1">MSEKCRLCLQSSDSVFATSIHDGQFRAKLEYVFQFPIVADETLPKQVCQQCLSAVSDFHDYSQQVLANQEQLVVLSKEKGRRYEAMKTEPTNEPSYHRSNAHATIDSQSGVPIKHEPVENAKSHCDDLDGSEPFEMVKIELPNDDDFYDDEIEASFETDIPAKVKRKSARKAKPVLQDEVDTDELNSDDEDKDEDFIPKVESIDGKVTKRRRKILKGGKHAKKGEGTAKEEIASEKSDGEDLEKQTEDNKRILEFFKFECELCSKSLENLACLQVHYRRHHGTKGYIRCCDKVFYRRFQLLDHIAAHEGTIKCAICQKSYKSSRYLGLHMMKSHSREEDRPFKCDKCHQSFHKEHLLKAHQANHLSEKCPICEKVVSSKYALKTHVSRMHGSDRNQICDVCGKEFRTKPAMERHINEHLGVDVVQKVQCHVCQRWFHGKYNLRKHIRFMHTEDGQVFRCDICQHESPNSRALLDHKKRVHVEERFECEFCGKRFKRKLYLREHIASHTGKPLYSCEVCGATFNSNANCYNHRKSKHPVEWEARKQAYLEAQRKSPSSDKKPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3A9</accession>
    <name>A0A084W3A9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005668-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012595</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525284">
        <property type="protein sequence ID" value="KFB44703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3A9"/>
    <dbReference type="STRING" id="74873.A0A084W3A9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012595-RA">
        <property type="protein sequence ID" value="ASIC012595-PA"/>
        <property type="gene ID" value="ASIC012595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012595"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022651"/>
    <dbReference type="OMA" id="TIMLNSP"/>
    <dbReference type="OrthoDB" id="7741176at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="404" mass="45603" checksum="C0A087FC6194B381" modified="2014-10-29" version="1">MKCQSTCVIENLKPQKDGPLMLRHLSASHSSQVKFLNLRSTVVTKEFLDEMGQFVQGIQIVDSLGVQQIILSKQFNLLHLDISNSRLRFFEIEGHVRLLTLVVSSGLLKKIPPTFRYLHAATVIEISECPIVTLDLAPFCSTFSLRALKLTKNKIRYIVNSSTVPCSPQMKQIELDENHIQVLNLELFSTSSRLLRAGFVRKNAIELVVGRFTSSSLLTLALSGNYLTRLDVCQWNTPALSSLHIGSNRLSDVPRCLGNLSQLDFLVMHRNRFTNFDIRSVAKLKHLRFLNLALNNLSSFAMSDKEFPPSLNRLYLGYNRLESLDLSYVPVPSCEVYVSNNLIGELDIDKVSLNVTLLDMGNNPLDCSWDEKKSRRLVKCIKNPNFDPAEAYNGDSSKVLERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L1</accession>
    <name>A0A084W3L1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000631-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3L1"/>
    <dbReference type="STRING" id="74873.A0A084W3L1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012713-RA">
        <property type="protein sequence ID" value="ASIC012713-PA"/>
        <property type="gene ID" value="ASIC012713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012713"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020986"/>
    <dbReference type="OMA" id="EPCAREN"/>
    <dbReference type="OrthoDB" id="9449012at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 6-like beta-barrel" evidence="3">
        <location>
            <begin position="245"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="634" mass="72969" checksum="A1035A559F16EF25" modified="2014-10-29" version="1">MTIVLFVLDTSPLMFQRAFIDGKTMTYLDIAKQTVEKFLKARKTFGLGENDRYMLMTCEQSPNHVKSGWKASLETFMSELKNLQQSERQSMGLAIKHAFDFLNHYWLGRDIDRFGNGRCPFYHDPTMVIVLSHGAWTDDENLFNLMQTSSCDLMLRRYRWDQRLFIIALRIPGNYVEPCARENRLTKIPCDEVMNRTCCLTGGTLYSITSGGMLKQCILELVESLQRGVVLEFNCPPAISLLSEVCFVIETNRPHCGHWPIPESYWVELICETLPPREAHPQITIIFEPSNEPDIRHFPYDSYTLKTSELVMQIVSNAPPGKVLPVFVNTDTILDKPFGYLKLNVARVAVKLIVLAYDYPVLLPLMRDLIRKYRMNPPRGWLGRFQKYAFTIPKYYYSHMRLVFRDVMKIPEALIQRILPPCKDYMPLSAALHLKKTQMLAAKVQQQIEESMLQRKPAFPTPALAQVEVAPLMETVIHPCTFQSNIVVPSNVTKNVTVYNYRDPYQTPRRELINAMAKMRDEFWRNTPVETQQDNASRRLGASNYTSKSVMLHCTEEQTNETQQINNNPYHKRMTNQLKRKVGPISKDFIFERYPAPKDTNSRTLVSTDASGPSSVATELSSIVETDEEVAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4B2</accession>
    <name>A0A084W4B2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4B2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012882-RA">
        <property type="protein sequence ID" value="ASIC012882-PA"/>
        <property type="gene ID" value="ASIC012882"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012882"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012882-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9807" checksum="B5F04684247A89FC" modified="2014-10-29" version="1">MRQPAAEMVEADSAEAFQRRSKEVTSGHRQRADGHNGWTLPNPREVRESRERSGDRESLGDARDAIGITNSACICAGSAQAAYYRPTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W588</accession>
    <name>A0A084W588_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013176-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020529">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W588"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013222-RA">
        <property type="protein sequence ID" value="ASIC013222-PA"/>
        <property type="gene ID" value="ASIC013222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013222"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="150" mass="15884" checksum="2F42A0CF0EE08D5A" modified="2014-10-29" version="1">MVLPSPMATPERLVRQLPNVILPPRVLVVFLVVLLLLLVELELVVEVIATTMGGMMSAPAVVASHDAAAAAGAIGGGSIGSGGGTKSVQILTAGGPWLSIGEVSGPQLELISLRFAHRRTDHYDQHDEHGQQHQYTADRHGHHRTVTHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5T1</accession>
    <name>A0A084W5T1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013562</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5T1"/>
    <dbReference type="STRING" id="74873.A0A084W5T1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013562-RA">
        <property type="protein sequence ID" value="ASIC013562-PA"/>
        <property type="gene ID" value="ASIC013562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013562"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022008"/>
    <dbReference type="OMA" id="KEATRWE"/>
    <dbReference type="OrthoDB" id="7762568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19471" checksum="B891C21853A22E70" modified="2014-10-29" version="1">MAGRNRFHTAAIVGNLVTLKEATRWEANSTDGNLLTPVLLAAAYGQSVSLAVLLKRGGDLTKTDRSGNSALHLAATGGHRECVECLLEAGCSVFEMNTAGRTPLDVAKLQREFEVVEVLERYEADLLARDPRKCADQRKRAAKRYEKLKQRYGAVISLNLGASFRALEEHTALEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6E7</accession>
    <name>A0A084W6E7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Developmental protein FluG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013768</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6E7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013768-RA">
        <property type="protein sequence ID" value="ASIC013768-PA"/>
        <property type="gene ID" value="ASIC013768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013768"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7448" checksum="8A6E003FCFA24776" modified="2014-10-29" version="1">MAFIVIGRMTLAMRHASDGLVHHPIWLPTSRPPENAYLLLSVRPVIITVASEPSPWRNGGANHIHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7A2</accession>
    <name>A0A084W7A2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002838-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014073</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7A2"/>
    <dbReference type="STRING" id="74873.A0A084W7A2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014073-RA">
        <property type="protein sequence ID" value="ASIC014073-PA"/>
        <property type="gene ID" value="ASIC014073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014073"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001024"/>
    <dbReference type="OMA" id="FKMTEEY"/>
    <dbReference type="OrthoDB" id="10057854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048998">
        <property type="entry name" value="STPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21107">
        <property type="entry name" value="STPRs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STPR" evidence="2">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="STPR" evidence="2">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="449" mass="51748" checksum="4A7288E53EB01FB8" modified="2014-10-29" version="1">MNGFFQINTYYNEFKQEPGATYAPAPIQQPSQQQQQQQQQQQQQQQQPQQQDRLVGRVVIEQPPVSQQGKPETSAKNQQRFLHESEEARAKRLARNAERMRQKRAAETEEQSRKRMAENAERMRRKRASESEEEYRNRMERNAAFKMTEEYRRRLAENAERNRRRRQNETELEKSIRRARSAARERLRRAMETPEQRALRLAKLAERMRITRERLWREIETPEQRAERLAKLAERMRIARANETPEQRAIRLAKNAARARQRFLNESPEQWIERKRKKAEYARQKRAAAAALGANGAPSATSTTSNSQNPGIMQQHQQPSMDSCTFPGQAPATLPETILHTTIPLATGSTSNSAPASTYVMNVKDGSKLAISTKPEQTASLQLHPEQVYPPPQVLFSGVEFKPHELLNGQHLAMQTDPNCPSNLYKLHLLPYPFGSSASGDQSTNYKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7A5</accession>
    <name>A0A084W7A5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease III</fullName>
            <ecNumber evidence="5">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">ZHAS_00014076</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28 30" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01021178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W7A5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014076-RA">
        <property type="protein sequence ID" value="ASIC014076-PA"/>
        <property type="gene ID" value="ASIC014076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014076"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012057"/>
    <dbReference type="OMA" id="MGPWCAW"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10843">
        <property type="entry name" value="DSRM_DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02843">
        <property type="entry name" value="PAZ_dicer_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002580">
        <property type="entry name" value="AGAP002836-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000003">
        <property type="entry name" value="Endoribonuclease dcr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000015">
        <property type="entry name" value="endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="18" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="539"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="27">
        <location>
            <begin position="778"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="25">
        <location>
            <begin position="1065"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1690"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="2004"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="2211"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1286"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1345"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1663"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1849"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1290"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1665"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1859"/>
            <end position="1877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KFB46099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2287" mass="258473" checksum="8D9D818CDC0886E0" modified="2014-10-29" version="1">MTVFHWTDGNIHTTALTPRDYQTELLAMAREENLIVCLAHNSAKEFLVVKLIQSLRSERAQPGASGKTIYLTARMDRTQLATMVSNLTDLSVFSVDASLNEETTTEPADSRVAEIDAADVLFFASDCTLLDHLNRGIVRVEDIGLFVVDECHNIYSHRELWEICAKIEQSSHAQNKRTKILGLAGPLHGAGCAPERLSWELQYLERCLRARIETASDITSVLRFSTKPYELILECRPVRQSNLTRQLRSLVGRQMAFLREHCYDPLAMYGLDGDIDGTGGEIDTENDDEDAELRRELRSIPDPRAAPLNYLQQYLDLLDEFGPWGADRGALELLTTIEKEKIRTPYERHFLLLCLVSTVFVQVRALVASVFVRYATEMERIKHYSTPKVLRLLEVLGWFGEQRSRPKDRSQAGMFQHNQLQQQQQQQKFIPYCFCRQPDCNELGKHYHSFEGQVCDVGERIDRLMDHLRSVRQTTDRLIQKYRTSNTGTSEAGGTGGIHQSPRHGNEGRTGNFRRRRFAGGGTTVGGPHWAQHYHSGHKSSDATDALCGLIFCNNRSMARILYVLLYEVSRSQPGYEFINAQYTVDKMVDPQTDAQHAALEHRKQEEVLKRFRMHECNLLIGTSVLEEGIELPKCNLVVRWNCPSNYRSYAQCKGRAKAPGAYHILFVTPDVTHPESEESVENLAVISDEVIEDDTINSDAATMDTNVRELVERSTDAMIERIAIYREVEKLLLAKCRNGEPAESELKHADCFNHCLEIYRPGKDTDGPSGALWLGNAIQTLNKYCAKLPSDTFTKLTPIWRCATTDRNGQKLFQYTIRLPINSPWKEDILGLPMPTETLGRRMAAYVACRMLHAAGELDNSFQSFGKEAFRAFEADWENFELEESDAKILTENSDPRPGTTKRRQYYYKRIASVFNDCRPQADMCAYLYHIRMELICPIPEEQNTRGRKIYAPEDSPQGFGILTTKLIPKISSFPIFTRSGEVKVSLDLCPQRVRLTERQLEMVNCFVRYTFTKVLRLQKSLMLYDANATENCFFIVPTIKRSDMPNGDGALGPAGSDVTVDWEFVEKIATNVHRSGPTFIPDEARKGYTFDVGKFRDAVVMPWYRNRDQPQYFYVAEICYHLSPKSTFPGSNYATFEEYYHRKYNIHIQNVRQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTIHPFPASLWRAAVCLPCVLYRINALLLADEIRRQVARDLRLGRENVDDFDGGKFQWPMLSFGWNLADVLRKTKEQKVAQGQVANGPTKTSSNEVKENGVTSEDSQTVETDEKTEAAGGGEDESLLEIGMWSNEMAAGVGTGDVNDTGEVAGRGPSSPSFLRYDSDCASNSSGNYYSSDEYDDDEDEYLLDDPVTDEDVGAQPSGTVASIDAPTAVNGKANSVTQQDTTVSVVSRLKIEFKSETVAEAIDSERDLQRQRTQQSIIQRSRLNEQLYQSSKNAIDGFSCSPAIDLVNEDERRQAEEAFAKAKTHTKDIIRLHGALVRWDEPLSGRHWRAKVDEREAERLAALMDDMGGSPFVEFVPYIDEGELFELLVRNGSVGERWLRLSDLYRLNERFFPERYTVFRGGSRFDHFLVDVAKGTDGQPEAKQIVLTISDPFPAIAAGQTACNYKPKQSGVQERTVRSNLTDSSYSTDEGQDGGFSFDYQPDLEHHPGPSPAIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYCRYDNVHEGKLSHLRSKQVSNLNLYRLGRRKRLGDCMIAAKFEPHDNWLPPCYYVPKELEQTLIDAKIPACHWNLADLPDIKRLSCDEICQLVKERARAKRIEEHDVVQNGSEADQETKDDEDDEDDDSVDIGNEDGSDYYSCFIPYNLVTQHSIPDKSVADCVEALIGAYLIECGPRGALLFMAWLGIRVLPILDSNPTNNQTTIARRGENEPASSIMQYGHWVAPPSPMVRANITFGGIEAGASVTVQELARLLEGFEAFEQTLGYTFQDRSYLLQAMTHASYSPNRLTDCYQRLEFLGDAILDYLITRHLYEDRRQHSPGALTDLRSALVNNTIFASLAVRHGFHKYFLHLSPGLQEVIDRFVRIQQENSHRITEEEYYLPDEDDDLMDAIGGGAGDGDGIDGRSVGHGTGEAEDVEVPKALGDVFESIAGAIFLDSDMSLDTVWKVYRKMMGPEIEKFSSSVPKSPIRELLEMEPETAKFGKPEKLADGRRVRVTVEVFGKGTFRGIGRNYRIAKCTAAKCALRQLRKLGYSSHHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7G6</accession>
    <name>A0A084W7G6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008924-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7G6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014160-RA">
        <property type="protein sequence ID" value="ASIC014160-PA"/>
        <property type="gene ID" value="ASIC014160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014160"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018845"/>
    <dbReference type="OMA" id="ENPHIQV"/>
    <dbReference type="OrthoDB" id="7741578at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="304" mass="32675" checksum="2AA96CB400B8E8BA" modified="2014-10-29" version="1">MADSSGSGSPQKAHAKRLAVILLVFTLNLILFGVTPVDGKRAFAIRMRSKSNHNTGAALGRNSRKNYQHMHPEGMGGMVRNPPVPDIQPPRPIGWSVDGHSNSHPIGPPPAYPGLGHHAVPAGGAPPAYSHSKMNPPSYGEAVGHHPQHSSYAMAAAAPLVAPRHYDYNHNSALYGDSNAIGSSYGSSYGYHGHRASSSPFSMGSILTGAALWHVAHGIGHHHHHHHHHHGEHGGINSEEHYYHHNHYHHGEGETSTLPPEVENPHIQVNANFDFGPSPNPQEVPQSHDDSTTTSETIQTIVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W814</accession>
    <name>A0A084W814_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014406</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W814"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014406-RA">
        <property type="protein sequence ID" value="ASIC014406-PA"/>
        <property type="gene ID" value="ASIC014406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014406"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014406-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="196" mass="21261" checksum="E7A85BD854B5F285" modified="2014-10-29" version="1">MAFTCHPVRLPSLRIPPVHTPLAATVARKTQTPACVGCVCFGIRKGVGCLVEAEGDPSSGKLDRFFAGHERVNESETWAPPFAFSGFSFIKFIERARMPFGKAVPPNDVITRMGNHLRHRLLECTFAGRAGPNRAAFFAVPSSVGPCGESPARSRRNESSSEVKDRPAMAMRRTLIFALAGLKLALALKPGNRECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W844</accession>
    <name>A0A084W844_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP008155-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014383</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021359">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W844"/>
    <dbReference type="STRING" id="74873.A0A084W844"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014383-RA">
        <property type="protein sequence ID" value="ASIC014383-PA"/>
        <property type="gene ID" value="ASIC014383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014383"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007983"/>
    <dbReference type="OMA" id="AMMENSD"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20048">
        <property type="entry name" value="FH_FOXD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF402">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="7">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="638" mass="68226" checksum="5A01235E4210383B" modified="2014-10-29" version="1">MMHPALATPLDLRPSGLLSSSASANGGPNHHGSMNEPSGPPPLYQQHHHHHHHHQHQQGHNQSVGPSSSSSSSNRSSSGSRARHRSRSSSGSETGHQHPPESTDNRAGTPSAGSTGGGNGGGTTGGKSGNHRSQSLVKPPYSYIALITMAILQSPQKKLTLSGICEFIMTRFPYYKEKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRTTLAQSMAFPGVFGPFAPFWIRKPVPVIPMHQFGPAHAAAASAAVSAGFGTVDTGGGPLAGLGPGARGGDFLLDSKLNLFGAVKMDDLNVAMMENSDFLQRNVDSLKISSAMNKFFHGYHQGQGVGTGNVGPMAVDMYDEATHTPSGLSIHPCNGTLGRESYGPYGSHKGSGGMALHSTQDDAPNGDRRTGEYHDGEQINGDLDLSSDDRIDVESEDDYKSSTERYHELLLDGRRSIPTPVTSHPQHPPSSASPPPSVPASTPLGPPPLRVPSTNGPAGDFSSPHCSPSRAVRDSDDYYIEEDEQSDMASSSGGSLPEETRGPTKEFQRQLYDDLQGPALHEPSTGTGNAPEADRPPSGYGGETTKLFDSIEVGGFAARKRKYGNTKGFSIENLIGCNVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8B2</accession>
    <name>A0A084W8B2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014350</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021403">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8B2"/>
    <dbReference type="STRING" id="74873.A0A084W8B2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014350-RA">
        <property type="protein sequence ID" value="ASIC014350-PA"/>
        <property type="gene ID" value="ASIC014350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014350"/>
    <dbReference type="OrthoDB" id="7763238at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="19470" checksum="B987F1E16578FDDC" modified="2014-10-29" version="1">MSDSEGERFVAAKNERSTFVTERKKPKVDLAGLREQLSQMAKVLEKMTAGRDNTEKKSIEFAGRVPDMRFPTTKNEAYYPNWLTARKWRREESPIVYVYEMLAVGKKACFKEETIIMYIASGLHELWQKAKVTIGRAATVKDLLEEIRWVEGVEAVGATSSTKSVLPWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9C2</accession>
    <name>A0A084W9C2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP011978-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00014823</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021687">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9C2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014823-RA">
        <property type="protein sequence ID" value="ASIC014823-PA"/>
        <property type="gene ID" value="ASIC014823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014823"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010167"/>
    <dbReference type="OMA" id="HAFQRND"/>
    <dbReference type="OrthoDB" id="7729466at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="73"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="103"/>
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    </feature>
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            <end position="210"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB46816.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="420" mass="49407" checksum="18B048A8B92BE6DF" modified="2014-10-29" version="1">MASLFHLGFTLRQKFLERFFIFSDSVDYFNLFNTFGTLFALHYDAKGPRKLFWMAYRALYVLSYLSYCYKAGWMFNHWEYNTASANVLGALGLCSGAFLRMLLIEHHYPAIEQLQRFLNDRTYQGSDPSWARQRRSRMYRQNNRFLVILVSAIVLESLCFLARLLLTRREFMLQFNGEVVGGSMVQIVYGTITAGWGIVYVLSFILFYMLMEGFRLEMEILVRSFQHLEDSLFPKHGEFIRTGLPMCEQNELAFWSDLKLRLNERIGRHVELLQNLRKLRSIVAPFAFLQYYSTFGLIADSFFIVSFEGFSGYSMAYILFASFLILESFLLSRGVEQLTELNHQIGMALYEFDWPKLMRYSTRFRREYNGIRRTMLLTIVQTQRSLKFTYGAQGEISMNSFAELMQKSYSMLTFMLQLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAZ6</accession>
    <name>A0A084WAZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015636</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015636-RA">
        <property type="protein sequence ID" value="ASIC015636-PA"/>
        <property type="gene ID" value="ASIC015636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015636"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8722" checksum="6397BAAEC898446B" modified="2014-10-29" version="1">MHHRCFLPFPRHLCNLIRRLLGVENRLPRALDTPIPSSQVQANHLFPETGPSDHGHFLCGRKDGRTVAIFRAAKSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB12</accession>
    <name>A0A084WB12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00015654</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB12"/>
    <dbReference type="STRING" id="74873.A0A084WB12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015654-RA">
        <property type="protein sequence ID" value="ASIC015654-PA"/>
        <property type="gene ID" value="ASIC015654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015654"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006653"/>
    <dbReference type="OMA" id="HLYDTEW"/>
    <dbReference type="OrthoDB" id="5873834at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000027">
        <property type="entry name" value="Blast:Protein patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="401"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015654-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139178" checksum="7F3ED12F85B5FB2D" modified="2014-10-29" version="1">MRKLIQRNVTWQAEDDLIWCRGKARGRRSAVYMRSLFQSYLYNLGCSIQKHAGKVLFVAILVLSTFCVGLKSATVHSKVHQLWIQEGGPLEHELAYTQKSLGEMDSSTHQLLIQTPKDMDASILHADALLTHLEVVRKAISVTVHMYDITWSLKDMCYSPNIPSFDTHFIEQIFENVIPCAIITPLDCFWEGSKLLGPKYPVHIPGQTNKVQWTSLNPQILLKEIKAQNYQFPFETLEQYMKRAGISTGYTEKPCLNPKDKQCPDTAPNKKSGQVPDIGATLTGGCYGFAAKYMHWPEELVVGGAVRNRTHHLKSAKALQSVIQLMGERELYDYWSNHYKVHHIGWSTEKASEVLRAFQQKFRAEVHRITQTEVTPVSYYGVYAFSSATLDDLLGKHSSPNPVSIGVGIAVVLVYTAFMRIRWRDAVLGQSGVCVAGVLLIAVTSAAGLGFCALLGIAFNAATTQVIPFLALGFGVDHIYVLTHAYATSDTSEQTGQVLKKAGMSVLLTGASTACAFFAGTLIPVPALKVFCFQCAVLMVFNLAAALLVFPAMISLDLRRRRSGRADILCCALPALPSTTHDLGRSRYHYHQQSQHPPQQQQGQGQSPAVDSETQRPEEDTLIECQTQSWLNFSMSRHAAKHYAPFLMKSSVKVFAMLLFSGILGVSLFASMRLSDGLELTDLVPQDTNEYRFLSVQGKLFGFYSMFAVTQGDFEYPNNQKLLHEYHEAFVRVSHVIKNDNGGLPDFWLSLFRDWLINLQKAFDRDYREGRITQERWYANASNDAILAYKLLVQTGHVDNPIDKSLVTQVRLVDSEGVINPPAFYNYLSAWAWNDVLAYGASQGNLRPEPREWIHTPSDFELKIAKSAPLTYTQLPFYLHGLSDTADIKTMITQIRELCSKFEARGLPNYPQGIPFIFWEQYMYLRTNLLHAEFGAMFGAAIFTFMLLLSLWGTLLVLFNVLTLQIQLLGVMVLLGIKLSAIPAVMLIASVGLGVGYSANVALGFITSIGNRDRRVRLALEQSFAPTVHCVMTSVLSVSMLYTSSFEFVVRHFLWLLLSAIVIGAVNGLFFFPILLSLIGPGAEVIPLQHANRISTPSPPPKRINKLSSGKPIILNNRRSSCSRSCTKPHHHHKHNNVNLNNEPSLTTITEEPQSWKSSASSIPSIHEKANVASATAAPTSASHLGGGSNVAGVGGVYSHPHAHHYHHHHHQQAPELQSIVLQPEVTVETHHHGGEHQNTKGSNNCVGLISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBK3</accession>
    <name>A0A084WBK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBK3"/>
    <dbReference type="STRING" id="74873.A0A084WBK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015566-RA">
        <property type="protein sequence ID" value="ASIC015566-PA"/>
        <property type="gene ID" value="ASIC015566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015566"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015566-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6071" checksum="8E0C23A95C814B8A" modified="2014-10-29" version="1">MLRSPGHLIGHGPGAGAGGVMGLHSHASSPPHARPSLFDSCHRKIRLIGGGPVAFLGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBM0</accession>
    <name>A0A084WBM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015586</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022371">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015586-RA">
        <property type="protein sequence ID" value="ASIC015586-PA"/>
        <property type="gene ID" value="ASIC015586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015586"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005764"/>
    <dbReference type="OrthoDB" id="7741230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="300" mass="33367" checksum="0640C8D0A5CF3C74" modified="2014-10-29" version="1">MQTSKRRPVNSHNFTSNDVSQRKAAARRFSEEKLRQIIKNVRRAADNFIVPRNGDGESDGRKFSCQKARPPEVGGGCEPTATAEWTVSCRRPTEHEIDKLMQGLTSAKSCDEPDRQSFLAIVDEQQVELELKEEAAPATEAASEALSDGEIESEESEISTASSNASLDEIAELPADVEDNLTYSTTSDESRPSSSYKDIEAELESSFFSEPPAEEMERMTFAMRPIEPDSDGAESYCETLSVDRPIIQVRIRSLPASFGIRLARIYVPPSDVPNEQLIDFAQIERNTKLLHARHNMLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBS0</accession>
    <name>A0A084WBS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001668-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015708</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBS0"/>
    <dbReference type="STRING" id="74873.A0A084WBS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015708-RA">
        <property type="protein sequence ID" value="ASIC015708-PA"/>
        <property type="gene ID" value="ASIC015708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015708"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004540"/>
    <dbReference type="OMA" id="YSAPAYX"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784763" evidence="4">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="22818" checksum="22527201998729F1" modified="2014-10-29" version="1">MAFKFVTFAALVAVARAGLIAQPAVTYSAAAAAPAVLAAPVAKVAYAAAPIAKVAYAAQPEEYDANPQYSFSYGISDALTGDSKSQQESRSGDVVQGSYSVVDPDGTKRTVDYTADPHNGFNAVVHREPLAKAVVAAPVATKVIAQPAVAYAAPVAKTISYAAPVATKTVISQPALAYAAPVAKTISYTAPVATKTVISQPALAYAAPVAKLATPVAYTTALHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCV7</accession>
    <name>A0A084WCV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004917-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016174</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCV7"/>
    <dbReference type="STRING" id="74873.A0A084WCV7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016174-RA">
        <property type="protein sequence ID" value="ASIC016174-PA"/>
        <property type="gene ID" value="ASIC016174"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016174"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009454"/>
    <dbReference type="OMA" id="YTACHER"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="91"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016174-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="275" mass="30808" checksum="9E5C045B893BFC95" modified="2014-10-29" version="1">MGKKLTECSQFNFADRTINMANSPTNHLITLAAFFAVGVVRCEISPRSSAFPGVFSFEMIMTKLQVLDYNVDRMAKSIARLVETAQPLIAEHRGSNFTSCSKLPVNVSGIFQVQPEKPFKKPMAVLCDQEYESGGWTVIQQRFDGSVDFYRGWQEYKNGFGSLEGEFWLGLDRIHQLTASKPNELVVLLEDFDGNKTYARYERFSIGDESQKYSVANIDGYSGTAGNSMSGIKGVPFTTLDSDNDTWEKNCAVHFTGAWWYTACHSRLLAECVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD75</accession>
    <name>A0A084WD75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016235</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022949">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016235-RA">
        <property type="protein sequence ID" value="ASIC016235-PA"/>
        <property type="gene ID" value="ASIC016235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016235"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16485" checksum="24DF4FD54587BD00" modified="2014-10-29" version="1">MMFRIDFWPAAYRFRDHHHHHRLASHVAPWRLVAPARGQLVSARASEMPTLEITRDVCCGETDSGAKGRPASGVTMDGRMMAHVDCLRLRRLSIGRQPPAASAVCALFIRQQHQENNNNTEQNKKKGIENKDDRPNMISVGGASPGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD83</accession>
    <name>A0A084WD83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016245</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD83"/>
    <dbReference type="STRING" id="74873.A0A084WD83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016245-RA">
        <property type="protein sequence ID" value="ASIC016245-PA"/>
        <property type="gene ID" value="ASIC016245"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016245"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009814"/>
    <dbReference type="OMA" id="TFHIVEH"/>
    <dbReference type="OrthoDB" id="5982503at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028039">
        <property type="entry name" value="CCDC32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31800">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31800:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14989">
        <property type="entry name" value="CCDC32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016245-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18344" checksum="55805E90C0A6C6B4" modified="2014-10-29" version="1">MSFADPWIEQDRQANHLASETTAVAASLEFEDNFTAQQLPPLNPREPQDNRLPDSDNYLATLEKRLNRLKTNPSVLQQLVERREAFMQSLLGGSTTLRSEAELELEEPVSNIELLRFIRPEQALSQAEIVQLVQHDHLQLEADECDEGREGEESGTESSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEH7</accession>
    <name>A0A084WEH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016610</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016610-RA">
        <property type="protein sequence ID" value="ASIC016610-PA"/>
        <property type="gene ID" value="ASIC016610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016610"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016610-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9669" checksum="9404856987E09B81" modified="2014-10-29" version="1">MSSTQHPSPFGVVVVDAESAVIGKADDRCRSSRAKPLSTIVQTREPIDGQIMSLRSAAGKINFLPFPTATGNRSSPANNDSRHKPVQLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF30</accession>
    <name>A0A084WF30_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MARCHF5</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING finger protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Membrane-associated RING-CH protein V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase MARCHF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ZHAS_00016942</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01023287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF30"/>
    <dbReference type="STRING" id="74873.A0A084WF30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016942-RA">
        <property type="protein sequence ID" value="ASIC016942-PA"/>
        <property type="gene ID" value="ASIC016942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016942"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023718"/>
    <dbReference type="OMA" id="KRYCWVC"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16701">
        <property type="entry name" value="RING_CH-C4HC3_MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000262">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="24">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KFB48824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="374" mass="42082" checksum="6F0407B7D9490E30" modified="2014-10-29" version="1">MLSDELESGATDEQQGTSDEQGQPLPINSSSTATERVNQSSAATDEQEERYCWVCFATEEDDKFAPWVQPCNCRGATKWVHQSCLKRWIDEKQKGNPYKSISCPQCQTEYIIILPSMGSFAFMLERLDIIAKQLSPCVAAGAIVCSIYWSAITFGAVTVLQTTGFERGLLILEQAEPLALLVCLPAIPAALVLGRMIRWEDMVLRMLQNTQYNIRKYPVISFMLPVTNEPTPSYPEPFPNNSINASEPLSVTRIFCGALMLPTVSTIVGKMFFKSIKNDLHRTLLGGFAFVAIKGVLKIYFHQKKHNRAKQRNILDYTQENIRKYGFRSQHLQQLQQQHQHLHQMANERAAQQPQAIANVGDEAGSGDNQRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFN0</accession>
    <name>A0A084WFN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017034</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFN0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017034-RA">
        <property type="protein sequence ID" value="ASIC017034-PA"/>
        <property type="gene ID" value="ASIC017034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017034"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="19113" checksum="BECB2C5DA79750BB" modified="2014-10-29" version="1">MHTMQAGSFPEPEAVSVSCSGGWQWAKMHKFTFAPDPRLRHRHSGGVQSRRHKFAHRHHRHQICMTQPNRIANRIVPSSRHRHHQHRRCIQLPARELSPADVYWDPPPPPSSDYLRLSKISIVNSGYPLQLEDGVSVFARCCSQHTEVAKPSEGPPFRLISTPRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFY9</accession>
    <name>A0A084WFY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023414">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFY9"/>
    <dbReference type="STRING" id="74873.A0A084WFY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017287-RA">
        <property type="protein sequence ID" value="ASIC017287-PA"/>
        <property type="gene ID" value="ASIC017287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017287"/>
    <dbReference type="OMA" id="TRTQENT"/>
    <dbReference type="OrthoDB" id="10064156at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784664" evidence="2">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="460" mass="46181" checksum="7C78F4414FE02C94" modified="2014-10-29" version="1">MNHRTRALVGLLCIAGLATGQLNQGYRPEFFSPGQGFQSVSAQISQSNVQQQFKRQAAGGGAGGADVIPHDQKKQTTFWWVAPDTPFKATKIGGGVQEPPGSGGDGDEGAAGAAAAAAGGAGGVAGAAGVASGGATSSFQSSSSRTTGSQTSGQTVGAVGTTTSLQSTTASRTTGTQTQTQTQGAGGFQQGTVATGAVGAGAVGTAGTIGGTRTSVSRTSSSSSRTFGQGAVQPAVIAGTTRSSSTTSNTQVNTGTVQPGVGAGGVRTTSIIRQSQTQTTSGVAPVPVPPPPPPPPVASTITTTGVRTDSITSNVNAVPRTTVDVTKTTNVDTQRFNTVQTNLYPGQPGQPGQPGSTSTATVVGTATTGITQPNNYGGTTVTKTQERSDGSITNKVITTGTITRPFYKQTTVTSDGYNYPVPETIPCYEPNKICAPNQFCNDGFVDESQLNLFNTNNQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGA0</accession>
    <name>A0A084WGA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00017334</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGA0"/>
    <dbReference type="STRING" id="74873.A0A084WGA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017334-RA">
        <property type="protein sequence ID" value="ASIC017334-PA"/>
        <property type="gene ID" value="ASIC017334"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017334"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004936"/>
    <dbReference type="OMA" id="YQRRQTD"/>
    <dbReference type="OrthoDB" id="7743893at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017334-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="375" mass="39640" checksum="0CE158D599C4EB5F" modified="2014-10-29" version="1">MGRKKKKASKPWCWYCNREFDDEKILVQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKESIDKVPNSLPNRSNIVIEIYGMEGIPPEDIREHEKQKNGNRSESEEEEPAHKKMKQPEAPTVPQGMMMQNMIPPHLQAAYGMNPMMGAMGGMNPYMVPPGMQMMPTMMGAAPRPLFPAAAASVATVASTSKATFPAYSSATISAPPTTNSAISAAAANNNGINNGLGGGDASKAAASSVIPNAGTATSKIVHPPEDLSLEELPAVIAHAAQAAAANHHKQIEELNRAAMIQRFQAANAAVANAAAAAASRPGMPIGMVPVSLGGPMPLMQPMMRQGLALGPPGGGNLLLGGNMLRPGPPQMGLGPVYTYTTVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGH4</accession>
    <name>A0A084WGH4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017435</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023571">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGH4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017435-RA">
        <property type="protein sequence ID" value="ASIC017435-PA"/>
        <property type="gene ID" value="ASIC017435"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017435"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017435-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="10783" checksum="82902663CDA56BB4" modified="2014-10-29" version="1">MAPGGASADAAAAVMDHVGDRDESHPLGSHRRLTRSTETSGLPPTTTACCKCSLALAFNYTTSASSNLDGDIQSIVQHWVSGGEIFGICNRCMQMYLSLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIE8</accession>
    <name>A0A084WIE8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018032</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018032-RA">
        <property type="protein sequence ID" value="ASIC018032-PA"/>
        <property type="gene ID" value="ASIC018032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018032"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001405"/>
    <dbReference type="OMA" id="MHFESEA"/>
    <dbReference type="OrthoDB" id="7765477at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784772" evidence="1">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="387" mass="43720" checksum="9D79B4A6BA42A29B" modified="2014-10-29" version="1">MNVSTVLFCFLTSGMLWFQRVGSYVIVNKDSDVYPDTPSSYREREFVESYQEPMATPLQDLIVNSSQMKNLLELYYLVQVVRSYRRPAYQELATIANGLFEQLTREDLRNELVNLLADVDGFEEIFNVGEYAEPDPLKEQLTNDYRLLFPLVARTLSELQNPETNGVDVLQGKLRQAMPSMLNSLMHFESEAYEEIEQENLIDKAIETTEATPVEMNPTRLEEIIHVTEIPVASLKDVVNDYDLEETKPSQVPTYGKIIKALSKSGEDEENAIVFLPNGNEVVYEVDPTSEESSKGLEVGNENNSPGVVLLTEDENMEKNSDPATDMKGHLPKAVSVKDPEMVALVPVIVEQLRVGNVTPEEEETLAEIFGELWPLMVAEADRLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIF0</accession>
    <name>A0A084WIF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018034</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC018034"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS018827"/>
    <dbReference type="OMA" id="MRTHGTI"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="28"/>
        </location>
    </feature>
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            <begin position="268"/>
            <end position="327"/>
        </location>
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        </location>
    </feature>
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            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="388" mass="44080" checksum="82D439B2872C8188" modified="2014-10-29" version="1">MANLSEVSYAMLFVCLIALINSISGYAIDQSTTSESNAAETEALKELTNFRNKLADNNIQVAKEAKSVNSLDELDVLQMLPKVISHMRKDTLTTKEREAFMRFYGSIWELIVEESRRHRGEPRNPILAALLASPEIRHGKQDIRNELGNDVERNSVAKVYQAGASSKAIVFDDKELPERILRMAAVIVQKYYQRKAKANPGNKRQKAMQARRLRKMSAHVRQHSDSDSIRVTIEVPRFKRANALPASLIDQDDLDEDMEAKIMAAIQAQIGNPSLEEDDDDDEEEEEADEPVPQENDSEYLDDEADYMGVLGDDDDDDDDDDDDDDEDIQADLLKAHAHNFENPSFNELLLLAARHRATQQQRKLERQHLAYRKSAPNTPSSYEDYQD</sequence>
</entry>
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            <fullName evidence="2 3">Ubiquitin carboxyl-terminal hydrolase 32-like isoform 1</fullName>
        </submittedName>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760010" evidence="1">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018121-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9951" checksum="978B42AAD81B5BD2" modified="2014-10-29" version="1">MKFCSIAASRLLALDGLLGCVFFLSTARTERERCVSSERPLHRVEIGEIAREFLEREGRRGKNIGVSRTSRSRLVESRTPRFLHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJU0</accession>
    <name>A0A084WJU0_ANOSI</name>
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        <submittedName>
            <fullName evidence="8">AGAP007057-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018521</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024071">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WJU0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018521-RA">
        <property type="protein sequence ID" value="ASIC018521-PA"/>
        <property type="gene ID" value="ASIC018521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018521"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013398"/>
    <dbReference type="OMA" id="RSCRLIY"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="7">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB50484.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="625" mass="69312" checksum="FBF7FF657D78112D" modified="2014-10-29" version="1">MHASQGYGSGPPMAAVGMTRSHSHTVNLLSEDFIAGYMEQGRMSVVRRFFCLFVTFDVVFISLLWIICVVITGDNVMHALETQVVHYKIDTSLFDVVIAALVRFIFLILFYGLLSISHWLVIALSTTSSCGFLISKVFLYNWTATQQPVFEVLLIVVSFVLAWGEAWFLDCRVIPQERYARNYFVAITNPGSMDARTPLLDPFLRASAGGRTESIGNFYSPYDSIHNSDDDEEEDAQDEEFRKMGTECVRKAYTLLESDGWKIEKVTTKGDTIQSCQQEKIGKVYKLTAKIHYPARKLLQELFYKIEDVPNWNPTLLESKIIRKIDSHTDISYQATVGGGGGVVKCRDFVNLRCWHLCRDGRVIEGVDLLPNPLINLSPVTEEREGLGSVEQTDDDDDEDDDCKEERSLNGANGKPSKSVPKMSQSHGELKINAEDTESAAAGETRNKTAFKTLSKSLGAQDFALGGGVGGGGGGGGASDPEDVFSDALTDDQEVKGSSHESKDAKGPKRKREGLRDVRDSSKGGNVYVSAAISIDYPGAPATSKYIRGENKVSCWAMRELENQKDHCIFEWLLCLDLKGYIPRYVLDTAYTTLMQDYMTYLRKYVAELRKQGKVPGGHGAPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK77</accession>
    <name>A0A084WK77_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">CO dehydrogenase/acetyl-CoA synthase complex subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018945</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018945-RA">
        <property type="protein sequence ID" value="ASIC018945-PA"/>
        <property type="gene ID" value="ASIC018945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018945"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018945-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8765" checksum="63B60D8571259162" modified="2014-10-29" version="1">MANQWGQQGWHEQRAVEIRKLMWEPRNPVRISLPPAPIFTGKPGKSESFVQFRFSTTSTKINESPQYAGTCGSRECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKA9</accession>
    <name>A0A084WKA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018687</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018687-RA">
        <property type="protein sequence ID" value="ASIC018687-PA"/>
        <property type="gene ID" value="ASIC018687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018687"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015336"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10679" checksum="22FDEDBE591461CB" modified="2014-10-29" version="1">MTVDVGQNESELGALRTSVVMLRHERAPSSKTLSSERTVCDYGPFPETKPLSPKGLHSRSEAIFHYPQTTFIASGERDVYVLKLEKIKLSPTEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLD3</accession>
    <name>A0A084WLD3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019076</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024222">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019076-RA">
        <property type="protein sequence ID" value="ASIC019076-PA"/>
        <property type="gene ID" value="ASIC019076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019076"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002033"/>
    <dbReference type="OMA" id="NDDAYAQ"/>
    <dbReference type="OrthoDB" id="8067653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="347" mass="38224" checksum="9843E3D45FF77C86" modified="2014-10-29" version="1">MSPVRKKGISSMVGIVAENDGDDTVNEDDHANRLLEDLSAADGEEDHAQKTDIERRNERNSGNLCKRSCSPGKRLGGVGGGGGTTSDSKSLDHKFNRLLTEVNGLRDQIGDRIETLNRRLTQTNRLFLTHQDYGNRSSKAGDLLLVGIPAHEGENLRECFVRIARRLGYTESEIPMVHIKRLATGFGAPASPGPSGTPGHPTRPRPTHYNPAVLDNLLRPGRKPPAGGRKPANAPLAPAVQVQFVFRNARNEFYRRYLERGKTGTCLELGELGYEGPGRVYVNENLTRCNLTLKAEAMRLKRDGKLKSVFTVNGQIYVKRTIDHRPELVTSSVDLLLLDGSKMKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLS9</accession>
    <name>A0A084WLS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019433</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024276">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLS9"/>
    <dbReference type="STRING" id="74873.A0A084WLS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019433-RA">
        <property type="protein sequence ID" value="ASIC019433-PA"/>
        <property type="gene ID" value="ASIC019433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019433"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000157"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11114" checksum="6A8F85E6491793EE" modified="2014-10-29" version="1">MTPPPPPPPPTPGAPVAPLAPSSNTPVGVSPTTGTTKAQVAVPDHNDQLMAAIRNGINLKPTKTNDRSTPGFIKRANESHDAGQSEEFGERAAKRWDLRVVVTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLY2</accession>
    <name>A0A084WLY2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019492</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLY2"/>
    <dbReference type="STRING" id="74873.A0A084WLY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019492-RA">
        <property type="protein sequence ID" value="ASIC019492-PA"/>
        <property type="gene ID" value="ASIC019492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019492"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022084"/>
    <dbReference type="OMA" id="CVTMPIT"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="299" mass="33627" checksum="5720162C07835C16" modified="2014-10-29" version="1">MSINVDIKLRRANKVYYEGETVSGIVQIICGSESKHDGITLALEGSVNLQISNKNVGIFEALYNSVKPITLLNQHTDLAPSGKLLIGTNEFPFEFPLICPKEPKTLYETYHGVFVNITYMLRCDIKRSFLAKSIQKTQQFIIQYRPVVERPPKEIQFSISPDTLQKTAKERISIPRFLLSGTLDSTDCCVTKPFTGSVTVHHTEVAIKSIEIQLVRVETCGCAEGYSRDATEIQNIQIADGNVCPKVPIPIYMTLPRLFTCPTLITKNFKVEFEVNLVIIFGDDYLVTENFQILLNRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN38</accession>
    <name>A0A084WN38_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007395-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DIS3-like exonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019707</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN38"/>
    <dbReference type="STRING" id="74873.A0A084WN38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019707-RA">
        <property type="protein sequence ID" value="ASIC019707-PA"/>
        <property type="gene ID" value="ASIC019707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019707"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002447"/>
    <dbReference type="OMA" id="WPEAIFK"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="4">
        <location>
            <begin position="519"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116593" checksum="CBC19F896BB53D51" modified="2014-10-29" version="1">MHKKAIEKKEKRDAGSSDEDSDDSFDEKMEVQLDMNQQKLVQLKCMIEKIEEQIHVIKEDYHREAKPVVNRKEAHTASLGTSRKEDKPTIKEKKPKKMRSDSESSRQDTKRKEKKHEKVAKGLPKRNEQTTRHRWGSVLRGKLLLMLFTLSSSQRRKYIEKRGIELGLLNPHPFKRHAKNYITPTKIIEESPATKIIEESPATKTVEKKVNGKLEQKPFEEQVNFLLNNGKQGAAESNTPELTLTDVRDEAQMIVQDRLESFVHQLVEKNVGYLMEGLIRINARHNTQSFVDDTTREGNVYINSIILRRCAMEGDLVRVFVMNQPASPAEGPQTANGAETDTDCLDSTIESAADDTIVEQKQTFSQNNVGFVVKILEKRNKRQCVGKFSPFGPGKKHYRTFLPRDMRIPPMRVFKQDWPNALIEAQLTAPLEGGDGDGKKVPASTEITEVLYQAEIIEWQNDIPIGTILKSIGKCGVLEVENESILVEHNLDVTPYGDDILAQLPSLPYSIPQDEIVRREDLRGECIFTIDPATARDLDDALSCKVLPNGNFQVGVHISDVTYFLREQSELDELVKLRATSIYMVDAVYHMLPKQLCNTCSLLPGQDKLAFSVFWEMHPDGTVLSTRFARSVINSCAQLSYEHAQMMLDNPKGDGLVEDLFPEIMHGHTVRSLCIIVNQLQSIAVKLRQRRLDDGCLKINQPKLTFRLDPATGRPIEYGVYKLRASNEMIEDFMLLANTSVAQAIHAAFPSVSLLRNHKPPAENMMKNLVRTLASFGHTFSYASSKAIRESMDAIVTGAEHPDAACSVLNVLLSKPMTRALYYCSAFASGPDQFKHYALAIPMYTHFTSPIRRYADCLVHRVLAASLGIDDEPKRTPDELQKLATICNEKKYNAKLAGDASSMLYYRHWLESVKQHETVAAVLGYGAHHIEIVLIHSGIVLKASLKKISAVASVVFKPIDPVGSLQLIPNDSFIEPVKLTIFSKVRVTIKLVHDAITICSMLPMPAEVLPTAKEESKPPAGQKDINVNVEMKSARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPE4</accession>
    <name>A0A084WPE4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020480</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020480-RA">
        <property type="protein sequence ID" value="ASIC020480-PA"/>
        <property type="gene ID" value="ASIC020480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020480"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10082" checksum="D59BB7EE2BBDB917" modified="2014-10-29" version="1">MASWEKETNVTSKDRKASLYPRGVVGNTHGKYVVPKQTASITGERAFSREVHRTDAAAFVLATGSGYPQLPVPGSSSSIENFHAPIPYYGAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPF3</accession>
    <name>A0A084WPF3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020354</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025075">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020354-RA">
        <property type="protein sequence ID" value="ASIC020354-PA"/>
        <property type="gene ID" value="ASIC020354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020354"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7702" checksum="0164BFFCC0BB3022" modified="2014-10-29" version="1">MPPHVFSPGRKTFICVTHQFTLQFFPCLTLFFICSPAVAQFLPCEDVPRYIFFPPKHSGTVKQLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPH1</accession>
    <name>A0A084WPH1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020433</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025076">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPH1"/>
    <dbReference type="STRING" id="74873.A0A084WPH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020433-RA">
        <property type="protein sequence ID" value="ASIC020433-PA"/>
        <property type="gene ID" value="ASIC020433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020433"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004052"/>
    <dbReference type="OMA" id="FGRIRED"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30937" checksum="3ACF3229F72B0AAC" modified="2014-10-29" version="1">MVSVDLVGQKVLVTIDNCVRVGDLTHADEQLGVMRLENIREINTNLELNQEFYYASEIQGVKVVDGIVDAALTKIKNHVFINQTDAIYHEAIKYIRLQSEFGVHMECIEFGRHSESPSLLSIVTARCIFIFDILWIRIPKDLAELLSSDYYRRVVHDSRLIKDVLLYRYRITLGKCFDTLVAHVATEKKTEQNVDYKLASIDISVQDCVTKYLKLPEKFYREDAVLAFRMLEEKDLLEAAKNVAFLVDLKNHFLSEILLKDVFKRCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ51</accession>
    <name>A0A084WQ51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020559</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525377">
        <property type="protein sequence ID" value="KFB52345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020559-RA">
        <property type="protein sequence ID" value="ASIC020559-PA"/>
        <property type="gene ID" value="ASIC020559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020559"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10498" checksum="5475B85B5A0F09FC" modified="2014-10-29" version="1">MQLGKPSHSTTIDVHPWPVEKMRSIAAVGSAISSSATRISRLAVRIGATADAIAEQDTYGTNQSMADASCKRAALRCLRPTGSSLLISAKCRYEFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQS4</accession>
    <name>A0A084WQS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020836</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525398">
        <property type="protein sequence ID" value="KFB52568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020836-RA">
        <property type="protein sequence ID" value="ASIC020836-PA"/>
        <property type="gene ID" value="ASIC020836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020836"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5724" checksum="F074023EBC2BA7B7" modified="2014-10-29" version="1">MWASGRYLSRSPYAGRLQVYGSGEILDALIGLRFLARVGRGDGPNEIEFHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQV5</accession>
    <name>A0A084WQV5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025775">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525400">
        <property type="protein sequence ID" value="KFB52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC020879-RA">
        <property type="protein sequence ID" value="ASIC020879-PA"/>
        <property type="gene ID" value="ASIC020879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020879"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009491"/>
    <dbReference type="OMA" id="SKITATX"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="29402" checksum="8EB2DC80BC558293" modified="2014-10-29" version="1">MCDYLLKESKAHNAHQSKITATXXXXXXXHSGVLRERNVGARDDGDERRHRRTATVTSEPEDPLAACGSPHNGASQSESEVETVSIAGTSPVMTSRAANTTQQLPTITVAGSLKNGAPKGSLMPATLLANGSNIMSLLGSSSGLSLQQLIQQKKIVINSNGTVLDIVPITDESEGTDMKLENEKLLADGTVTNDNTESGNSSEGTADETPQVAAQVAVVQAQSPTSGTPQYITVTASPWSFFNHLRPPFSWGLSLDGKTTQTSGKTTTXXXXXXXNLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRS0</accession>
    <name>A0A084WRS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007005-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021196</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026183">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021196-RA">
        <property type="protein sequence ID" value="ASIC021196-PA"/>
        <property type="gene ID" value="ASIC021196"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021196"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009426"/>
    <dbReference type="OrthoDB" id="10070859at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021196-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="23768" checksum="91FD5A4E0FFCDE7D" modified="2014-10-29" version="1">MVMIASGHSPNGPPEHHPPNPYADGHSTLPPSYRSVHPGVETLHRQSPSSPQAQPQCSSRNLGHTTRDDNIQEGGEAKPNVPDGAAHHTPSIIKIDDRRHSMVPSTEGIGGTVGSLQEAPTKRRSSVPGTSLIDTRTESAAPRNDSDLMSAKTYNTGLKDLVTIVTISGTIEPSASAPGKAVYTTSNGSNGGSVPSASTGNGATCTLLNSNSTPLVATVIPVSKSSTGGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRY0</accession>
    <name>A0A084WRY0_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP005235-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021263</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021263-RA">
        <property type="protein sequence ID" value="ASIC021263-PA"/>
        <property type="gene ID" value="ASIC021263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021263"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6544" checksum="1BB0C2DF226E0F04" modified="2014-10-29" version="1">MGTSNGHDRKRAMKRSHKSGPKRSIRVHRAVHSTSRTVRQCRRRRWDGTSIFSTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT63</accession>
    <name>A0A084WT63_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013053-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021728</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021728-RA">
        <property type="protein sequence ID" value="ASIC021728-PA"/>
        <property type="gene ID" value="ASIC021728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021728"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000817"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785392" evidence="2">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="264" mass="29914" checksum="96879019F8B6FFCF" modified="2014-10-29" version="1">MPKEATLLIVLLLGLVTVVSPTPTEHPVITTEHTAIVEMVSNGATASDHLKRLKRICHESGVVEASYCLAFKQLQSHLGKNIIQEIDLLGQEQPKKVTATEDICSNLTELVKHLPSEWRSKELKSFAQDERCISVCSKTNGSEDDIQSDDCWLLFVGFQALIASHPERERIEQVQPKMNKEKLYDSEKPLGGVSETTQNIPIEENTTRKTKYVQAEQRALVKKSRTYDPNDFNNQNYYLYFLFSFAVLGTLYGIYRCTDDTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT73</accession>
    <name>A0A084WT73_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">S-adenosyl-methyltransferase MraW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021839</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB53417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021839-RA">
        <property type="protein sequence ID" value="ASIC021839-PA"/>
        <property type="gene ID" value="ASIC021839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021839"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021839-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6149" checksum="3CEBD5731E03DE8E" modified="2014-10-29" version="1">MGPWSKPWLGEELVKFCDFTSGCGTGLAQAFVKTPTALGLHDSSPADGGSRDHPEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTN3</accession>
    <name>A0A084WTN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Type I phosphodiesterase / nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021812</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021812-RA">
        <property type="protein sequence ID" value="ASIC021812-PA"/>
        <property type="gene ID" value="ASIC021812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021812"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14875" checksum="608AB8D2B83EA760" modified="2014-10-29" version="1">MRKITYREWRVRVCMFAWGWRESTLGLWAPHLARIREAFHPNEAGGVSVEAPFRRTQGDRAGERPNLALWIKANLFHQGRTGALPSLTDHVSAVATSKVPEKRRTQLNCLRNCTIVRFGCSSSCWQKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTW6</accession>
    <name>A0A084WTW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021907</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021907-RA">
        <property type="protein sequence ID" value="ASIC021907-PA"/>
        <property type="gene ID" value="ASIC021907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021907"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11914" checksum="51F8963BF9882E22" modified="2014-10-29" version="1">MLSEVSIAPTCSFQASGSNCIDFYSSLLPIALELAFPKAPRGDVFAGIIFQLYSTLMQHGSISQLHSLHTLLRTSNRRANGFLTSFSHRLEADNISEQAPQADGREGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUQ0</accession>
    <name>A0A084WUQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022190</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022190-RA">
        <property type="protein sequence ID" value="ASIC022190-PA"/>
        <property type="gene ID" value="ASIC022190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022190"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="50" mass="5471" checksum="8D10BB0F1ED72584" modified="2014-10-29" version="1">MENRAYIGDSGGYGATLPMGYMQTNGHQAHRDGHGYTVDCQKIASKIIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9T6</accession>
    <name>A0A084V9T6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000048</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000233">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523861">
        <property type="protein sequence ID" value="KFB34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9T6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000048-RA">
        <property type="protein sequence ID" value="ASIC000048-PA"/>
        <property type="gene ID" value="ASIC000048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000048"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="201" mass="22246" checksum="008A73CFF64EA669" modified="2014-10-29" version="1">MEITATVRRAVKLSSAGSQRSVVPVQPIPYGFHSRLLEARTYTSEAGARIKHAIELQSSGNQGQSRLPDSMRAKRAALRKSEISYNRNYRVAGRRCFFRPPLSRAPDENKRMVEIGEKRSLFASRGENHGSLRVRNQFGSSAWSGFFSPTGWVQREGGEGEYKSQSVKTAGQEVTHYVTARFGGLFSPAPHPTHIPTPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAG2</accession>
    <name>A0A084VAG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000730-RA">
        <property type="protein sequence ID" value="ASIC000730-PA"/>
        <property type="gene ID" value="ASIC000730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000730"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5382" checksum="B611A9BBB5ABB5B1" modified="2014-10-29" version="1">MTKALESCWMCVSFPLVSRSGETVRFQTLDNYLARTGTVKSDPAGRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAI9</accession>
    <name>A0A084VAI9_ANOSI</name>
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        <submittedName>
            <fullName evidence="1">AGAP001806-PA-like protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">ZHAS_00000825</name>
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    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000825-RA">
        <property type="protein sequence ID" value="ASIC000825-PA"/>
        <property type="gene ID" value="ASIC000825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000825"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018435"/>
    <dbReference type="OMA" id="AMMSHRM"/>
    <dbReference type="OrthoDB" id="10334900at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14309" checksum="375EAABEA1E0D689" modified="2014-10-29" version="1">MPAMMSHRMSPKTRVVFKFIFGLGIWSFLVLGFFKLNGDQVMQHQFHQTPINGRLLLNKDNRWTGNEATSTTTDRYLSPAAMAGAMAGVDEVLVDNRAGKKMGKDGKIPNSPKTHLPASYSKVLTARGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAQ0</accession>
    <name>A0A084VAQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002505-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000864</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084VAQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000864-RA">
        <property type="protein sequence ID" value="ASIC000864-PA"/>
        <property type="gene ID" value="ASIC000864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000864"/>
    <dbReference type="OMA" id="FINCVSF"/>
    <dbReference type="OrthoDB" id="8195947at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="16966" checksum="412175E8D4ABAD8C" modified="2014-10-29" version="1">MKVATMRSSVKEGSTYQNREPTSQHSVFTDKVNYGGVIDSLNLKTDKVHQHRQVGGSQKGRPTGKPTPGSSSSDATDTSGSSCSDGDSSSSSYDEPNLPYPGFTEFSLKYLAQDTKPRIWCLQLITNPYPFQQHVVIFYAFSALYAPQCCRCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB01</accession>
    <name>A0A084VB01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001066</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001066-RA">
        <property type="protein sequence ID" value="ASIC001066-PA"/>
        <property type="gene ID" value="ASIC001066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001066"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10584" checksum="C4639C30F30FCD7E" modified="2014-10-29" version="1">MAEEYPYSRIPLTNDCFRAGYDIQGQDFPESPNVQQLTHAQRLAHMNPKGQDFPESPNVQQLTHAPRLAHMNPKGQDFPESPNVQRLIARYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBI6</accession>
    <name>A0A084VBI6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Zinc-activated ligand-gated ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001662</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01007260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001662-RA">
        <property type="protein sequence ID" value="ASIC001662-PA"/>
        <property type="gene ID" value="ASIC001662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001662"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011021"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6834" checksum="40763D2F7C48B8D2" modified="2014-10-29" version="1">MAPAGAADVDNPISVKPNSTSPRSDRRRKKTQQPQPEGNRKKHGNNARNPTEASAGAATSLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBZ2</accession>
    <name>A0A084VBZ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009588-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBZ2"/>
    <dbReference type="STRING" id="74873.A0A084VBZ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002236-RA">
        <property type="protein sequence ID" value="ASIC002236-PA"/>
        <property type="gene ID" value="ASIC002236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002236"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000969"/>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="51"/>
            <end position="90"/>
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            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="235" mass="26963" checksum="1697AEEAE75F4D6F" modified="2014-10-29" version="1">MRTLQHTVERTVKNTPECTSISSSFRAKKKLSCYMAWMSCLGTFRRVAGGSRTLDRKRTSKRLASVQDNSPPSKPSNSVRSSTSPSGAPRLIRTLTTAGSWGERIVTVNLLSDSVLTMSPYRGADTKTKYNLHFLDQYRYHLIGQLVDEKTLTAFEERIVRIPMPRRSLLVLYGPPRYQWEHAVLREDIKERRVCLAYREFTPMYLQGGSEYSQSEEIFARAKQFWDHRTVGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD33</accession>
    <name>A0A084VD33_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP001596-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002826</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD33"/>
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        <property type="protein sequence ID" value="ASIC002826-PA"/>
        <property type="gene ID" value="ASIC002826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002826"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010629"/>
    <dbReference type="OMA" id="VFHYTSK"/>
    <dbReference type="OrthoDB" id="6620433at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF13">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783365" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19677" checksum="83D7B87979DE8C9B" modified="2014-10-29" version="1">MMMLLVAFLQLSTVAANGKYIYGDSEELDERYQEILQHLKEAAHSGSPVHSSVSEKSKTVPVPVFQKVGVPVPHPVPVAVPHYVKVYIPQPYPLQVNVEQPIKIPIYKVIPKVIEKPVPYTVEKPYPIEVEKPFPVEVLKKFEVPVPKPFPVPVTVYKHIMQNEKTHRNWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEK0</accession>
    <name>A0A084VEK0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP003674-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00003558</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEK0"/>
    <dbReference type="STRING" id="74873.A0A084VEK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003558-RA">
        <property type="protein sequence ID" value="ASIC003558-PA"/>
        <property type="gene ID" value="ASIC003558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003558"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004248"/>
    <dbReference type="OMA" id="NNNHGEK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF6">
        <property type="entry name" value="C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="314" mass="34527" checksum="02447AE913EDF80B" modified="2014-10-29" version="1">MSSPHEDEDQDLDQEINVDADSDCQSRVSYNSGSEDIDLDGDGNGSCYEESDVTSDHQTHPPEPTTRSPNENLPFSISRLLAKSFEREQKDKDALSEDTSPEGLLKAGHHITSGAPGSLQYAAGALYSYPIYPGGHVLRVPPQRGPCNPLSWSLPPLHPAALAHQAVKDRLAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEALSKGFGQPPPSAAPPSAPTPGAPLAALHGLQPWAEAHTAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEX5</accession>
    <name>A0A084VEX5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003673</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524784">
        <property type="protein sequence ID" value="KFB36519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003673-RA">
        <property type="protein sequence ID" value="ASIC003673-PA"/>
        <property type="gene ID" value="ASIC003673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003673"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6942" checksum="2E274DABFDAB7D0D" modified="2014-10-29" version="1">MSRGPSPIPATTPLKPKTRRNHRPGQAASTSRAKPHPIRTTNTQSVKEPVLAGPRCRKKPPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI41</accession>
    <name>A0A084VI41_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP007792-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524849">
        <property type="protein sequence ID" value="KFB37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI41"/>
    <dbReference type="STRING" id="74873.A0A084VI41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004873-RA">
        <property type="protein sequence ID" value="ASIC004873-PA"/>
        <property type="gene ID" value="ASIC004873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004873"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004839"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013703"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021310"/>
    <dbReference type="OMA" id="LAXVPEA"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000009">
        <property type="entry name" value="ADAMTS-like protein 3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="450"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115714" checksum="0FA97AED509BFD31" modified="2014-10-29" version="1">MASNEFNLCSVSCGGGIQVRSVECMDTNGHYSAQCDPSSKPLTGQPCTTGIICNAGSAGSSSSSGIVAIAPPSSSSSASDFEGLTTAGDGMVAGDRAAGQASLNERLMKEKAAMHTMERDPTLMTYNDQPYYAQPLRQDRLPKAEKIVSQRVPGEATYIQDTEWSPCSVTCGEGIRRKPFRCKIFLEFSKRVAVLNDSLCHAYKPLDEVERCVMEPCSYSHNHEETYLKDGNRQSLENIKVHAAVPGKTYSWREEGYTSCSASCLGGVEELIINCVRDDTGKIVSPFLCSPETKPEARIRTCNDIPCPPRWNYSEFTPCSKSCGFGIQTREVTCIHEVTRGGENTMIVPNSMCTTKPQPDRQYCNIIDCPVRWEVSEWSKCSKSCGGGLKERRVECKQIMAQEHKVERPASMCPSSKPPDKKPCNTKACAPEDQRPPIAGTNSTFIQHDPKKNKITLKIGGAATVFYGTQVKIKCPVKRFNRTKIRWSKDQQPLLKTKKIKMSKKGALRILDVTFREAGIYTCHAGLSHADLKLAVKAKPGAENQPNEEHERHREGADLNALRAHSYGMTNGNEDEKGGRRNRDRNRGKNRQRQQHDANLNENDGTEDEEPLRSHSQMTVSGSTVPSDASNAASSGTRTMPLPHFQHLLAGLQTFSNTKPHQFLIEQGYDPFDGSIGRPGEHDEYADPPRPMNVYQLLKSRTSPGTGDTVGDEPMSHDGQIAEGYDFEWMTTPWSECSQTCGANGGGYKLRSAHCMLRMSNTSRTVDNSFCEDAGLPVPDTVDKCGNIECPRWVTTDWSACQQSKCFSWHTALQKRDVFCQFEGERGDSEKPCEDQEKPVTKQECYNELCKGVWRVEPWSDCNAACEGQGIKYRILQCVWYGTKKPAGNACRDQPRPAVMKVCKGPPCIANHCTVTSNSVARLVGLIFITEQRATSRALVRACPICAATVPSRAKTKEAFKETETRSEGIHAKREPDLVGTEFGQTAAIVPSTERIGYPNHNVPPPFLSMQACPPKCAAINELVNGGAWWLTPTVDLPTGERFRSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ12</accession>
    <name>A0A084VJ12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013127-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005125</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005125-RA">
        <property type="protein sequence ID" value="ASIC005125-PA"/>
        <property type="gene ID" value="ASIC005125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005125"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000472"/>
    <dbReference type="OMA" id="HINDHAS"/>
    <dbReference type="OrthoDB" id="6755972at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005125-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="376" mass="43744" checksum="843143C02C978483" modified="2014-10-29" version="1">MKANCKERRVKRFSRQHAVEHELDALIKDVESKLKVQTARDPASLDMTHIVPRRLYERMKRLEMDLPPFDDREFEGILAVRLQDIRQSAGPDGRVRTGGSSHGTEATTDDGDDTDGGESRAGARAKPFELTVEQRTESRQRATEAGGNWMERFLRKTSNERIRWQTKYYRTDQKLLDKPLFQQIEELIDLGAQDFSEWLNGLGAEKSNITRDIIKQLFSIEIEDEMARAIRVDTKEVRAIPAEAAYHWNLESMALQKRIAQVMRSDRRAARASRERHVAFGRTLPVELRTSCRRDAIDSIRPDFPDDLRTLKALFKDIRHLRSVRYLIEHLHERAEIQRPRYLTELGLFRSRSHASATPFYQKVLPRKVILDSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ14</accession>
    <name>A0A084VJ14_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Prolyl 4-hydroxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005128</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ14"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005128-RA">
        <property type="protein sequence ID" value="ASIC005128-PA"/>
        <property type="gene ID" value="ASIC005128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005128"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005128-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8264" checksum="41FC1BEB8A4C94D6" modified="2014-10-29" version="1">MRRSAEPSGVDQLMPRQSSQAALPGTKCAAIEPGASGEFRSVDKCAAPGLGQAPLTPAAYITHATRGAGRGAGWEVASRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ90</accession>
    <name>A0A084VJ90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP008807-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00005302</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524860">
        <property type="protein sequence ID" value="KFB38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VJ90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005302-RA">
        <property type="protein sequence ID" value="ASIC005302-PA"/>
        <property type="gene ID" value="ASIC005302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005302"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023300"/>
    <dbReference type="OMA" id="IPHYACQ"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Apolipoprotein lipid transfer particle"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apolipoprotein lipid transfer particle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.230.10:FF:000007">
        <property type="entry name" value="Apolipoprotein lipid transfer particle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.50.20:FF:000003">
        <property type="entry name" value="Microsomal triglyceride transfer protein large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
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    </dbReference>
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        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vitellogenin" evidence="11">
        <location>
            <begin position="44"/>
            <end position="694"/>
        </location>
    </feature>
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        <location>
            <begin position="3723"/>
            <end position="3905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1990"/>
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        </location>
    </feature>
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        <location>
            <begin position="1994"/>
            <end position="2022"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="4327" mass="494954" checksum="ACAD7763C5AD4D32" modified="2014-10-29" version="1">[encoded data, 4327 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJD7</accession>
    <name>A0A084VJD7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005354</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005354-RA">
        <property type="protein sequence ID" value="ASIC005354-PA"/>
        <property type="gene ID" value="ASIC005354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005354"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8195" checksum="232C5234E5A0D1D7" modified="2014-10-29" version="1">MCMSGLRTSSTLINRRSRSGHSCRQGSAADDERFTSRYSQALRAGPLSAPAEHTAQLKPFALYAPLHTFTHSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJS2</accession>
    <name>A0A084VJS2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005530</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01013862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJS2"/>
    <dbReference type="STRING" id="74873.A0A084VJS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005530-RA">
        <property type="protein sequence ID" value="ASIC005530-PA"/>
        <property type="gene ID" value="ASIC005530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005530"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000085">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="18376" checksum="CE7EB331DC0105C3" modified="2014-10-29" version="1">MSDNQETVPEGWEKRTSRSTGMIYYLNIYTKESQWDLPTAPAEPANTNEPSEVQCAHLLVKHNKSRRASSWREENITRSKDEAIEILESYRKKIQSNETTLQELAQRYSDCSSAKRGGDLGMFKRGMMQKPFEDAAFALKVGEMSDIVDTDSGVHLILRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKH7</accession>
    <name>A0A084VKH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKH7"/>
    <dbReference type="STRING" id="74873.A0A084VKH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005873-RA">
        <property type="protein sequence ID" value="ASIC005873-PA"/>
        <property type="gene ID" value="ASIC005873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005873"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004557"/>
    <dbReference type="OMA" id="TVANNRW"/>
    <dbReference type="OrthoDB" id="7614304at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="208" mass="22663" checksum="12212EFAE2EFD114" modified="2014-10-29" version="1">MATTNSYEQGLEDYDEAADRAEREQKEQAGEQQYNNMLKPMLTLFNVISTVLSSGRSMRSTVATADGGNKNENITLAAGKSTSGGDNENETATAVAGGRYIKGDPLNGYYDFVISEGSYKFWVVFQLFTAGLVLYATFAAIYYSKVSPLTSDYDYIDYLNGARSFSGGRSMVTQPGSTVWDTVANSRWFGPAAQAFEIVMSAIENAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKR5</accession>
    <name>A0A084VKR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005837</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005837-RA">
        <property type="protein sequence ID" value="ASIC005837-PA"/>
        <property type="gene ID" value="ASIC005837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005837"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005837-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="229" mass="25532" checksum="D01E6412E0FED1AF" modified="2014-10-29" version="1">MAILHSTPPFLQVMAQWLSSVCFEAFMRCTLRLIVLWQPPGREWDVAVVYPANVFLIVYEVRLARGHGHAYAFKEKPECARVIGLRPGPVEIMNCNSQPRQANGQTGHISHSAVVVVYLSTISLAYGRRPTVVVYAHTFVLPAQGDGTTQANLLLLLLWRLPNGGASSACTIQVSCPTVRHSTKRPKTVVGDKNRRRKKPKAPHKRKRPNDRRDRPNQTTEPAAAVENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL60</accession>
    <name>A0A084VL60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008494-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006105</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL60"/>
    <dbReference type="STRING" id="74873.A0A084VL60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006105-RA">
        <property type="protein sequence ID" value="ASIC006105-PA"/>
        <property type="gene ID" value="ASIC006105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006105"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017063"/>
    <dbReference type="OMA" id="CDKVTTN"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21388">
        <property type="entry name" value="GAT_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11820">
        <property type="entry name" value="SH3_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000009">
        <property type="entry name" value="Putative signal transducing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="777" mass="84346" checksum="F376A27C96D51B1A" modified="2014-10-29" version="1">MSLFGASSSLNQDIEKATSENSTTENWGLILDICDRVNNGSATPKDCLKSIVKRLNSPNPHVVMKAITLLDACVNNCGKQFHLEVASREFETEFKKLLQKSQPKVNTKLKLTLKQWSEKVFKSDPQLDLIPSLYKKLREEGHDFSDPSATPKRETTLSKDPNVVSSQQEEDDIAKAIELSLKEVKLNQSPKMLSSSGGTTSSSLYPSALLSAAPVPEPRKVRALYDFEAAEDNELTFQAGEIIMVLDDSDPNWWKGQNQRGEGLFPSNFVTADLSVEPETLNTVTKKTVQFSDEQQKSNDSDKDALQASATVEINEEKIDRLLHLIHEADPEDPSQDTEEMLQLEQLVNQMGPMIDAELERVDRKHAQLTQLSSDLVDAINLYHNLMREPDRSSSMRAMSMGAMAMGGGMQGPYGLPPGPGGHPAGPASMGPMYGMPGMFPSMPDGGMYSMGPGQQPVSMDGGSSMQRYSTGHNYYDPAAMNAAPMADHSQSHQTMHHPHPLHHQQQPPPQPSQQVPLPVVSQNGPVTNGMVPPQANAAPVMSMGPSITSQQVPPQTANNTTNPQGMPPNMTVPPMAYNNPTSPPPTGLSGPQAQAFRQMRPMGQPGQPGQPGQPGQQLPPVSFPNYVPQQPSHQQSQPQLGQPPQHQQGPPQHHVPVSVGTAAQTTAPSAANMNHHQHHHHPQQQQQQFPMSMPPSHFPGPSVAPAPAHHLQQQQQPPTVFMPQMGPTSNPPMGNFSMGPMSMFPPGAGTTGAAGPLSINTNHPGPQNIPIYQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLA5</accession>
    <name>A0A084VLA5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Putative ionotropic receptor ligand binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006149</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLA5"/>
    <dbReference type="STRING" id="74873.A0A084VLA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006149-RA">
        <property type="protein sequence ID" value="ASIC006149-PA"/>
        <property type="gene ID" value="ASIC006149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006149"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016146"/>
    <dbReference type="OMA" id="GHMQKWA"/>
    <dbReference type="OrthoDB" id="6614738at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056198">
        <property type="entry name" value="LBD_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24061">
        <property type="entry name" value="LBD_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783625" description="Putative ionotropic receptor ligand binding domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ionotropic receptor ligand binding" evidence="10">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006149-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="663" mass="76302" checksum="4C0FA29AC511D96A" modified="2014-10-29" version="1">MCPQVGARVTSTILSLLLLLAIIETHRTVGDIPVDDDDNEQLLTVVPCIRRLCEKYFHSDRAMKGSLAIINIKPDASAFQLNILKSFNEDARHEMGVMVKDARKKHWNASHVTEKAKNYLMLIGDSSELAAPIHQLRRLPTWNPLAQVVVLFTSEMTPLVFEIEVRNVLQELFDNSVLNVNVMVQRYNTSVLEVWTWFPYESGGCADNIDQIRLVDECEYVEVEPDEEANVRGSWMFRERHHFSDFGPKIPKYYNYCPLKISTSIWEPFVVGNESHIEKGLEVLMLDTITARMRLVPVYNVIEASRATARITADNQTGLYADVIQRRTDLMIGGLYENPISRKLLSATIPYYQDDLTWCVPTARHAPKWLNVFIIFNIWTWLIAIFIIFAAAALIYRFNYVEGLYRENYTWVLLQSLAFSLSVYAHYWPRRVSIRFFLIGYMFYGLHWNAAYHSFLISVLTRPRYEMQIATVEQAIEAGFRFSGAESTLPHFDKPDAISRHLAAVYRVCPRMDECLALLRTERLQAVAISRAHSSNSRSIGEAEMYCFPKTDNIYTYSVSMLAKKDFHLLPKVNDLIRRISESGLLGKWQKESEKIRIDEGGEDDNVGADGQTILRLDHIEGAFLLGAVGLGLSLVAFVGELVYYWAKRKYRWRNNLLDRWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLG4</accession>
    <name>A0A084VLG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006291</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006291-RA">
        <property type="protein sequence ID" value="ASIC006291-PA"/>
        <property type="gene ID" value="ASIC006291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006291"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="169" mass="18961" checksum="4842BE5B132F1FC8" modified="2014-10-29" version="1">MSGPLPYLLLPHQEVLVRFDMFPNVSQVISQRWSPSSVWARWGWEHAREAGVCVYGQHCGQRLTPSFGATAKEQEEKVWYGISPSRRCRTGLTGTLLAPELGLLQRRHSPDTVIPATRCHMRRCSKPPRARAHSRALAAILCSAPIQSIVEALRFLPGYQSYARSSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLN2</accession>
    <name>A0A084VLN2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006367</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014528">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLN2"/>
    <dbReference type="STRING" id="74873.A0A084VLN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006367-RA">
        <property type="protein sequence ID" value="ASIC006367-PA"/>
        <property type="gene ID" value="ASIC006367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006367"/>
    <dbReference type="OMA" id="TMNCRSE"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="25403" checksum="1940E74A430C7B72" modified="2014-10-29" version="1">MNARSQTFDLRMEGRQVDEAVSSIFHTILFHRSLGKFMYTGEAMYSIGTIGYRDVDCDFIDFTYVCCMSPLLEQKLRHEIGNFSRQLRSNDSGGTGQISLEFFQRKKTRWPFQTDCIPWEVWTIRLELMTLTNEDDRLVCRERVSDMLTDKIFCITEIMNRHDYVPKIPNQAELDMVFDTSYPDVQPYLFQFKFSTAGPTATSVSSTMKKLIKETLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMS7</accession>
    <name>A0A084VMS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008779-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006622</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006622-RA">
        <property type="protein sequence ID" value="ASIC006622-PA"/>
        <property type="gene ID" value="ASIC006622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006622"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008187"/>
    <dbReference type="OMA" id="IDYIVLC"/>
    <dbReference type="OrthoDB" id="7730465at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="209" mass="24184" checksum="E74CF532852EE50A" modified="2014-10-29" version="1">MVFVFRFFRTKIGKLHEFLLRNSKRFLISSLLLGLATGTLHWLSIRYPALPMQLQENLRTFPVQITFCTLSLLSIGIMLSVGLYKRHLEAKARQVRFAIRQRYVDYIMLCLMVSVANSGRRHLQSPDKEGLTVAQLECYRQEIETAINRFRVRARKLLHEPPSSVTSSTPFLERYFRLDGEHFGEEILALKRDTNSLVNVPAIKGLLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNN6</accession>
    <name>A0A084VNN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007016</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524988">
        <property type="protein sequence ID" value="KFB39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007016-RA">
        <property type="protein sequence ID" value="ASIC007016-PA"/>
        <property type="gene ID" value="ASIC007016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007016"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="23189" checksum="B4EDC26775FED7AB" modified="2014-10-29" version="1">MSDGVELKSHLTAEGQVIPWRNPTGYYFSTHPKGSSKGYRLCPCESEKPIPTLANYCRSAALLPRDQANPYKDNDIRLPRTPQDLTVQRAIREINQVSPRRPGLACGEQSIRWRLHFVTKTARESSYHRLQPNLLVQAVKPEGVYDNRLLQANGQMKLNTSHAPVRPWERLYTRGKSERRGNASVGNPRAPPYRSVPFCFGHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQY4</accession>
    <name>A0A084VQY4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007164-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007851</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQY4"/>
    <dbReference type="STRING" id="74873.A0A084VQY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007851-RA">
        <property type="protein sequence ID" value="ASIC007851-PA"/>
        <property type="gene ID" value="ASIC007851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007851"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015422"/>
    <dbReference type="OMA" id="IDTWTEQ"/>
    <dbReference type="OrthoDB" id="6630523at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783993" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126675" checksum="2F0A133879E0747F" modified="2014-10-29" version="1">MAKIYFLLVAFCFIVRSSHGEPNYQPQQQPGGNDFSGAGGGGNSLYNGNLQQQQQQQPRPYPPSPARFRPIRNGSRATQLTPVQVQNPPQLIVGQTGFQPSAPILESGSSYHGAAVAPHVPPFGPSTLQQQIVPPASVFRDPEPTTHRPPTGAGPGDVKYHPCNNVPWVPIAAPPEYPPVRNPGGTVGVAPPPKAAPSGPSPPIKLQVAPKGQVQSVRAPLVHTGAPPVIAAHFITKASADNIGPSTTLQPITLRQVSASYFTNKEYAPPAKLLPIQDEGKPLAPIPLPNLSATPIPPLYTAGSFHSDPYKFYRPYRPVEPILELGHGYPVSSKSMSDSYTRYPHDPTKKNNSVFEVEQFASSASSSVYTTVSYSNGGEDSKPEASEKRNIATSSNGSSGANLRPSNNVAGDDDTEYDSEEETERSPPRTRTTVEVSSIVPQTRYYGSTTTSTMRPPSTVRYSTFQDQTTPRPPPSSSPPPPPPSTSDLGNGVQIIYSANLQTNSPINPVNNGLSEHDTTDDDDDVEDSTEVTERQKVLSNTLGPPTIMASSSTTPATTVTETDSSPTGIYTEPFRIGSSLPAQFQRQSTPEPASQTVGELSTPSVTTVTPLPSSLTATFGGYQNLHQSTKKPKQIQIIIPYQTYKKPEPFRPLPDSVHLDDLDYNAPEESSIVTSKHSSTGRLVGTTPAKSANAIDHAEPSKHGTRFIENDSVKYFQSTAHLRDILQRETTQPFSKPPTKTPPKPAKVKKVRPVEISKESKPFTVRVPKMTPLPPVVSLSSLTSVRGGMERITTPLPTDLPPGTRVPQSGEQFGTARPAGPLIALSKYAKPVTPHYVNVTRIRVAPTTYAQKSRTTISQLLRTTKIIPKGPKLFGNDLRVPESTRRPPLSPASTTYAHHRRTTFLSTSGGPSSTSTTSRTTTSTTPTTITTKTTTTTTEQPVAEESTVEPIYERNDWDIDPNELQRKIDTWTEQEFGSDDFARKSSTLSLHRVTKAIPWEFLTSTMLPSLHDRPGKAGARSGWHNVKIAISPITKEKIYVVTPQPWTAALLNHHHHNHHHHHIDQDDTRILTPRFSVRPTPLYYKGGGIFQTGSSTVDVSPESVNDLLEQKPKHRFSSLGGGANLSGTTSGTKGKHQHLLQQRKYVRKKLPYVTVRPGSSREDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR65</accession>
    <name>A0A084VR65_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008273-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015465">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007940-RA">
        <property type="protein sequence ID" value="ASIC007940-PA"/>
        <property type="gene ID" value="ASIC007940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004622"/>
    <dbReference type="OMA" id="KHPRKCS"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="355" mass="39795" checksum="6589E94031C7DE6C" modified="2014-10-29" version="1">MQEVEYFTGNLTSGMERKPPRKCSYDLLDFQNSTQQYQRQQCIRGYNKCDENVNYSVDPMLLTLSDEDSSGSPTSEMDNCIKFMEKPTLIKRFALGFLRSTEESLPLMCHKSSPTSPQKKLNDILSEDIYTLDQIVSSKFGDSCQQSFVGSPQRLPPTFNGGSNAAPMTTSVADGLEYEFKRNLIRQTNSASSSPKRFPTITPSKHADSLNSVNLGKDSVELDRASWFQAGLPRELSLEVLTQQSPGAFLVRRSATKHGCFALSLRVPPGPGPKVVHYLIMKTERGYKIKGFTKEFSSLRALITHHSVMPEMLPVPLSLPRPQNIPIKCKRTDDYDTFSALNEFSKLFSDLDICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRB2</accession>
    <name>A0A084VRB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007998</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007998-RA">
        <property type="protein sequence ID" value="ASIC007998-PA"/>
        <property type="gene ID" value="ASIC007998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007998"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007998-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="17854" checksum="E696EF82F5DA035F" modified="2014-10-29" version="1">MCPLVCSMLIYVSLYHDTTAKASHLGAGGGAGKAYTGATSPICSRMLLGVGRGGQTRASIDDRFYMRPRLVRHTGRRTQQGPRNRSDARTAQDPPTKTLGYAVRVCVQLDKFQVRRNVRKVCCRAVAGASPGGGLEGEGGGGVGGEESEVNMTMHPSTEEAMEAAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS56</accession>
    <name>A0A084VS56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP001452-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00008234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015819">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS56"/>
    <dbReference type="STRING" id="74873.A0A084VS56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008234-RA">
        <property type="protein sequence ID" value="ASIC008234-PA"/>
        <property type="gene ID" value="ASIC008234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008234"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016701"/>
    <dbReference type="OMA" id="VFPKNHE"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000006">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="239"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB40800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="410" mass="46368" checksum="56A89A4804A8D36C" modified="2014-10-29" version="1">MACLNTLKLEIKTLEQVFPKNHERFQILSATVDELSCRFIGRNGKQYVIHANITETYPSTPPVWFAESEDTSISNAVQILTNTNGLDNHVINQVHILLRELCRQHTVPLPPDLETLKKAFQPNGGAAGQLQHPAAHQQQQHGLSPQQLLPALQQQHQQLQMQQQQPIEEIDSDCDDIEDVVGESDQESEGEEDLPLEMDDGRSTAKKDEMEVEHLATLERLRQTQRQDYLKGSVSGSVQATDRLMKELRDIYRSDSFKNNMYSIELVNDSIYEWNIRLMSVDPDSPLHNDLILLKEREGKDSILLNIMFKESYPFEPPFVRVVHPIISGGYVLVGGAICMELLTKQGWSSAYTVEAVIMQIAATLVKGKARIQFGPTKGQYSLARAQQSFKSLVQIHEKNGWFTPPKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS76</accession>
    <name>A0A084VS76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001345-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008257</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS76"/>
    <dbReference type="STRING" id="74873.A0A084VS76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008257-RA">
        <property type="protein sequence ID" value="ASIC008257-PA"/>
        <property type="gene ID" value="ASIC008257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008257"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003646"/>
    <dbReference type="OMA" id="SRYHMER"/>
    <dbReference type="OrthoDB" id="6371642at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783895" evidence="2">
        <location>
            <begin position="19"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="3">
        <location>
            <begin position="164"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="5">
        <location>
            <begin position="442"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="708" mass="82102" checksum="EE1AD7C5E9F62F41" modified="2014-10-29" version="1">MRTLVVFVLAATLALASAALVPSSNQVKYAEKDWLHKQEDLLLLFRHLYEKDWNPQLVAYAKNFVFKDSAELYKHEPTAPWAKKLYAYYEHGLLPKGEVFSVYDDVHREQAIALFNVLYHAKDWETFYKVAAWARYHVNEGMFVYALTVAVTHRPDMAGYVLPAPYEISPYHFINTEVVQKAQQYKMQGYFGMKKVDGVYTVVIPSNYTGWYVHTNAEQKLSYFTEDVGLNTYYYYLHTDYPFWLGGEKFGLHKDRRGELYLFEHQQILARYYLERLSNELGHIPEFSWWEPIATGYYPDLQYYNGHSFPARDNYYHVDQEVNYRAIRQVVDYEKRLRDVIDQGFFVLPDGKTVNLSTPESVDILGNLIQANPDSSEHRFYKYVAMFARIIMGAAIEPVDPHQAIPSVLEHYESAMRDPVFYQIYKRIVGYYYQFKDHLPAYTYEQLYFPGVKVEGVVVDKLQTFFDHFDVDITNAIDIEPEPYVEGKYTGFGEIEYKPDPVVIKASTVRLNHKPFTYKISLTAEKPGKSVVRVFLGPKYDEYGGLYTLNANRENFYELDYFVQELTAGKNVVTRSSVSFNGYVKDRTSFYELYRKVMAGYKGDEKFSLDASEAHCGFPNRLMLPKGKKGGMPFQLFVVVSPFVEPKVPLFTGFDPVLSCGVGSGARYMDGYALGYPLDRPVDEKVFYTVPNVYFQDVVIYHKSQGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSG9</accession>
    <name>A0A084VSG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein FAM186A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008444</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525048">
        <property type="protein sequence ID" value="KFB40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008444-RA">
        <property type="protein sequence ID" value="ASIC008444-PA"/>
        <property type="gene ID" value="ASIC008444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008444"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000440"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008444-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="18659" checksum="B1122308BCC7E144" modified="2014-10-29" version="1">MFRAYGSLPPSECASPLMASAVTGEPTRLGPFDVPDWPPALDPMALDPVASECENAGGAIGTKPLVRRSISLFDSDSQRDVPGSIASAYGHQRHQQWRHRSKYRPDNQLPPDARTLTGMLLSDENLFHTEHGSLEGYEKVANHWQHRLVKVELRQKTKRDSDATEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSI1</accession>
    <name>A0A084VSI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008477</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016036">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525054">
        <property type="protein sequence ID" value="KFB40925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008477-RA">
        <property type="protein sequence ID" value="ASIC008477-PA"/>
        <property type="gene ID" value="ASIC008477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008477"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="247" mass="27567" checksum="8F255906B43DC969" modified="2014-10-29" version="1">MASVSDPSPCSILVRTCVYVRNLPRRVQHDAHKIRIAARAPVTDAAGFQCSGEAKDTKEKRKKNNQPKSKCARKGRENDSEERTGGTKRMGEKQECLINFQFLSSLHSSMTVAKGPQEEGWQGGDRMDRIDQARGRGENNATEETIGEGGLLNVSELDRGTATCENGRRRSGLPWDRASGRQAAPKAQHQTKRRSVLTYKHTHQRPCAPNTHKHRSGASIERSDLAARLKECAAIVWKAAERERERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSY0</accession>
    <name>A0A084VSY0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008529</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008529-RA">
        <property type="protein sequence ID" value="ASIC008529-PA"/>
        <property type="gene ID" value="ASIC008529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008529"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7704" checksum="7EF47B83F5A6F30F" modified="2014-10-29" version="1">MASVAAFPLRESSIPLNRFGIRPRRSPLINWITQKRLKRAGETLLRWIETSKPATDSRLESQGASVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT36</accession>
    <name>A0A084VT36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008684</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525060">
        <property type="protein sequence ID" value="KFB41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008684-RA">
        <property type="protein sequence ID" value="ASIC008684-PA"/>
        <property type="gene ID" value="ASIC008684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008684"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017436"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11520" checksum="6F9F7B9E6E680ABA" modified="2014-10-29" version="1">MKNRKLGMAGVGAEMDLLTVPTKITPVKQMLAELQSDDEEPGLGYTHTLVSTRRSPRTINPISMPSCCDTRPDPDTVLADPDLAFGLGLFVRQKVDCVVRSISGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTK6</accession>
    <name>A0A084VTK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Sodium/hydrogen exchanger 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008894-RA">
        <property type="protein sequence ID" value="ASIC008894-PA"/>
        <property type="gene ID" value="ASIC008894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008894"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9726" checksum="AB3992D65E26F1FC" modified="2014-10-29" version="1">MLPILRPFACAGRNFSKPKLPRGFSPNGARGEEEKKRARSTSSRSMVLCKYSPRTTVMNETVSATRSALLWTGDSPRRQDNVGVHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTM5</accession>
    <name>A0A084VTM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003646-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008915</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008915-RA">
        <property type="protein sequence ID" value="ASIC008915-PA"/>
        <property type="gene ID" value="ASIC008915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008915"/>
    <dbReference type="OMA" id="CVSYMDI"/>
    <dbReference type="OrthoDB" id="7765295at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008915-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="351" mass="39318" checksum="90F2013B6EA62A53" modified="2014-10-29" version="1">MCTCLSIAKTQHLLCGLSAKGTGSQRIEAILSRQLQYKYDNPYYKLYRDVDRIIITEDTKISPNYKTLLRQPSPLPQKIRKLQQLFPPVHRMPFQKHTDIVAMFEALRRKELEIYQFYHDASTSTLHDNIDLLVDRTPLHLRQWPVPPIIGDKELRSIRAESESSAEVNSIVLSQGRFSDLQVDVSADSLSFVPETVPASTQQSTQQGISSQSSLLRSQVVSQTVHQDISSQSVSAAIDNPILSESYGYEVPALPAIEDFPHVSSTSSSGSEFLANRRTIVARRGGVVYHDSQEAGPSGIQMNQQQRRQNEPEAAEPAMKRRRASPLPMNPSPTDFHPRHAGTRTPRLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTX7</accession>
    <name>A0A084VTX7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCCIP homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016551">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTX7"/>
    <dbReference type="STRING" id="74873.A0A084VTX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009026-RA">
        <property type="protein sequence ID" value="ASIC009026-PA"/>
        <property type="gene ID" value="ASIC009026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009026"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010122"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009026-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="301" mass="33802" checksum="65979CEDC395DFA3" modified="2014-10-29" version="1">MTSKKVKVEAEEDDERRMDTKSGSEDSSDDENDEAYEGDEGITVDFEGRNPIDPDLDGIKQLLGQLFVKAHIDLSEMAGVIVGQNYVGSVLKQAYNDGDEDDEDEDTDMEDPCQVVFGVTTVINLSNKQDLTSVRQLKKMLFEKAEKYATELVIQQFREALEGGTKTTGLLLNERFINIPAAVCVPMCENLLNEMERARSKGMPYTFDYYLMFVKYYQQAAAGDKSAEVIYSNDEEEYFIKDSCASFDYSVQKETTTALAGQWQKKDEELQPFRKVLLIEASKLPGIVATIKNLVSSVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU68</accession>
    <name>A0A084VU68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009115</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525101">
        <property type="protein sequence ID" value="KFB41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009115-RA">
        <property type="protein sequence ID" value="ASIC009115-PA"/>
        <property type="gene ID" value="ASIC009115"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009115"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009115-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="11953" checksum="116AD461862EBA8F" modified="2014-10-29" version="1">MVLVLVISTSAAARVYLWVRQDTRASCIPHCLGSGLWPRTKSHEPQSCVAIRSRCSSVSTVVAPNPVFRLSSSSTVAHSHPAYISSIAIGEGEHERTASHRVTLVHHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU75</accession>
    <name>A0A084VU75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009124</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525102">
        <property type="protein sequence ID" value="KFB41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009124-RA">
        <property type="protein sequence ID" value="ASIC009124-PA"/>
        <property type="gene ID" value="ASIC009124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009124"/>
    <dbReference type="OrthoDB" id="196393at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9260" checksum="E225CF125E6DFE35" modified="2014-10-29" version="1">MAEFHNKPKSKVVGIEPTVLHPTHDNLHWASRDLTIQLLPSHYTTGQLILRCLAEVGTIYSEVSQAPLESSRKEPIPERGECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUP5</accession>
    <name>A0A084VUP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010470-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB41689.1"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS011987"/>
    <dbReference type="OMA" id="CTIGPCT"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
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    </dbReference>
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        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="23666" checksum="33975CB041973582" modified="2014-10-29" version="1">MCKLVQKSLRQASCNVAIPCCYFLVRFVLFVVLLGLCNAQEPVCDPTLTSFHADPLSCTQYYTCFNGVATLQTCPDQKYYDASRTLCDIPENVPCTIGPCTGTTGLATVAIPGDCTGYKLCLNGTEFDMKCATGTLYDETYGDCVMAKDSKCEENPCLTVDPATASPSTFYPSLKLCKNYIICNKQTPVVRTCLSGTVFSPTVAKCVPPADYTCPPGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVD9</accession>
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        <submittedName>
            <fullName evidence="2">AGAP000690-PA-like protein</fullName>
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        <name evidence="2" type="ORF">ZHAS_00009496</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC009496-PA"/>
        <property type="gene ID" value="ASIC009496"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7743965at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009496-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="228" mass="25241" checksum="686A1EBDDFED51FB" modified="2014-10-29" version="1">MHGDKFLRSRPTISRWQSWASLRGVRPAQPGASRPTTKLLCVWSTRNARNVYAEIIRRLGDFLGMHVLVVHLLVLATLLGSVSLGQLKPDYLRYLRTRKPSHPLELHVEEVLEVFRTGQRPSSYGVSNRAVNSFLANQRLRATTARPCTSTTTAAYTTSSTEANTFPTPTFENSMPDYKRLFQPSITATKYSGHPAPATIIIKETDLSAVPARSALVSSAEDIDTADS</sequence>
</entry>
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    <accession>A0A084VVV5</accession>
    <name>A0A084VVV5_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP012952-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVV5"/>
    <dbReference type="STRING" id="74873.A0A084VVV5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009759-RA">
        <property type="protein sequence ID" value="ASIC009759-PA"/>
        <property type="gene ID" value="ASIC009759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009759"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018404"/>
    <dbReference type="OMA" id="YANCLTH"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    </dbReference>
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        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="448" mass="50618" checksum="98139454C25EC6A5" modified="2014-10-29" version="1">MQPEQTPNRAGVPEDSKKAVQQQQQPQHQQQKREQNQGPNPTQAASNASPQQPSSMLLKRMQKKAATAKRAIAYDPFPPVGTKVAISSVSNKLLYIHEVNDAFLSLVTRCIKHADEIDETLQQPPHESDIVFAPFDDCYYRAVVTKVEGNNSTVMFPDFGNVLTLPWSEMKEIRDVSVKYANCLTHAVALREGAPFSAAVEQFLNELVEAHQFELTLVEDGPTPGVKTVELRHVESQYLLGAKVRSMTTPAVKKAIKLEATDPATYKPVYDTEFDDTSIRSVIQQHEEHELVIVEASELENKQIAAIFAKSEVAFANMMRECQEYGQLDRNEYFGEPEVNYGCLVNYEGAWVRAIRLTSDCENQFFLLDLGLVCQLDSSCPKRRYPPGLTRKLFCSEFVVENIEFLKKEMKGTSNLTDSLRGLKLKAKVFFDEETEAYRIKIISIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW32</accession>
    <name>A0A084VW32_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004018-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009843</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ASIC009843"/>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
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    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="7"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
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        <property type="gene ID" value="ASIC010250"/>
    </dbReference>
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            <begin position="73"/>
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    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB42540.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010250-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="9696" checksum="48E68F34E6CCF904" modified="2014-10-29" version="1">MQERCNPRVRCATATVGNLPESNGMSAFSGASTIGKPTASIATIHPSGAGGKVAGGGIVAAAVEARLRATGGAANGAGRRRSLQRDVTPTAQFSGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXA2</accession>
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            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10306" checksum="08383960F05BB144" modified="2014-10-29" version="1">MATHGGLASFPRQLTHVRFYVCRRSTASKDSAKVKQGHDRETVLETDKGAETEKNRLDVSPICLSVAFDPLKAIAVRQMVDGNYWPVRPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXN1</accession>
    <name>A0A084VXN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010466</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018102">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010466-RA">
        <property type="protein sequence ID" value="ASIC010466-PA"/>
        <property type="gene ID" value="ASIC010466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010466"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42725.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="20652" checksum="0B66D07576E16C0E" modified="2014-10-29" version="1">MYITTTLNRHKKFTSLVRRNVVTPQTRRLIALFLRKDAVDRGHSSPYLHTCCSANRVGWSCKRQRTRTVVEQGDGSWRAKGTKISHFLRKTERNAENECGTNWKPTEHNVVLEEERGAFYSAMFVWFVLLVIMMSMPARPVRVNRGQHRYLHSNCSENQGVAAVQSRSQGVRCCSLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXS8</accession>
    <name>A0A084VXS8_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00010518</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXS8"/>
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        <property type="gene ID" value="ASIC010518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010518"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010518-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6743" checksum="FA44B1A9A284E48D" modified="2014-10-29" version="1">MFDQVVYTTMLYNVSTRPSAGWNRTPEQKKGYDVCEGRQMPTLLVISRQEARAILAGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYQ5</accession>
    <name>A0A084VYQ5_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00010783</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC010783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010783"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="180" mass="19903" checksum="FD88B7C9DC2BA41C" modified="2014-10-29" version="1">MISVVPPFRKPPLALVNGTGFPTDVNYMFSARQYDDDDERGRNAKGSLYLAPPAAGCVRGRAFDSPVGGWRKAGGFPNLQPKVASGRAYEAHENKETSYVTRRSVDEFRVFITASRPRPQVVGSRAREEMQMQMTGPGPMELNGSISGRCMRFVLATARQEEGWVSPPAIIRSRDDVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ40</accession>
    <name>A0A084VZ40_ANOSI</name>
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        <submittedName>
            <fullName evidence="4">AGAP007099-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VZ40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011011-RA">
        <property type="protein sequence ID" value="ASIC011011-PA"/>
        <property type="gene ID" value="ASIC011011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011011"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014491"/>
    <dbReference type="OMA" id="YNFKMLS"/>
    <dbReference type="OrthoDB" id="6346242at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035317">
        <property type="term" value="P:imaginal disc-derived wing hair organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057507">
        <property type="entry name" value="Sha_B-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387:SF1">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23328">
        <property type="entry name" value="Sha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Shavenoid isoform B-like N-terminal" evidence="3">
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            <begin position="115"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1180"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1939"/>
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            <begin position="781"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2004" mass="218821" checksum="E9C73D7154B0B680" modified="2014-10-29" version="1">MAAETDRKIAPNHRRIHPKAAQCRSSPGGWSRFRRDNYDALPTRTCSRRRALDRGRRCWLGAMLTLTMGLLMLACLPGTEAAAAPLPKSPPAPGYGRGHPMFKRMGGMADSTRISNLTRLHSGDLFYTFESEKCDTDTCVGLSSGTAELSIGGDRSGGAGSGPPRVPGSTDHIKEIGKLLAVTPNDSLISSCRVGMTKSQPCRVPLDMSADAGIECKCQCLPHLSTYREDLGICVDDIRECTLAPFISGSSSEKIPFVFLPHRGQIVHPSREIGFPGVKMPMCAVSAAQYLTSNGWAELRNPIDTDVPFRLFRDEGRIYLQWLGEPELRQRMQGRLVLVHLMCRDMTPRLLLPDGRTAPHHHDDMQMPMNQNIFTPCIAFRVVGTPIKYVNNVTEVTFSSETHVEQQSGLSTKEYIVIAVCSLCLGLIYIASVFLYIHMKKRKNRAGSDDDASAMKNDYSTYQQNDQVTFGVGMGAAVSPFGGQARASFIGRNALGGSQRQVGGPTVGGHRGLGNNVGLHAEEMGIVKSNPLLKHFPNLSDNSGFISDNSNSVSEFEDDLTTDVEKQVGHSTNLRLHSSTHLKPCLPEENVSIVEELNNEEKLESMKSIVNGTMRRKLYFNPAYFEPHLLVSPPPAAIEFLNKIREVITIAKYKMSSKRFQPSLNIIPEELQQAAGSETYAAVQTAPASRRSSLISSRKDSSRKSVCSGCPGCEKKPNGGESVMVPSSNCRNCGDKQNSIRKWLEDVSSTHGDGIAEADIYGSKTNLLAAEESKDRATEGGSKGSDGDGGITNVAFVADQSMESLKSGDDRAAPESLPIRPEIKKQPKALRQVKQTGSLHSDSSSTSDNETIVANSVKERAASVVRVPSASKSVRSDTSSAPKIVSHSLKSEVTGKVGKFGPMSDGPGALMKNSSFIYEEAQKPSQSNQDLYIRNTNNSVANLETNKVYDKRDLYSITGSEIYNNPQFETSPLMPHKKLPVGPHSSHHHHHHGKKFGIGGKVHAPPVAPFGTAAGKRQQEVHDQYANVKQMKLRNISEMPDMVYEALAMDQRKIKSWSERHADRLMAAETAEYNLDSSDSRFSSIDRHERYRNEKFFHDFLNSDQECNTLGNRSGKNSFSKYQPDSPIYSRKSPHYLIVDYETDSLERVTSKTPMSFNTSTTNSSDPGSQPSPSLSTALPLEEEVEIRNAIYDRVEGFRKDTDTIKTEREAVSIRSEEYEDVPQASAKKAPKIKCDTPFQGSITIEVEHSPDECDLSTDSDQFEPDTLDRKPKRGGQSAAVSRHRSNVWESDRGRSVVDSSNMTSLPADLNIVLKSTGSFKHETTFGSLREIYESKNGKVNVSNAPVRSSFSNLADLDVKTGKLLTLETRHSRRQRTNALDPLIPAPKLMPPDLIPPESAVSNGRQAGLYDHPRLQPRKVEDYGVSPKNLACWSTSDKLSNQPTGPAPKPNFCTGENYESINSLTAESDSTQFTGISDHDQSTGSSSNSTGKTRPERKLPNYSHVQKGQSIGDQSLYITDKTEYARIDEKSNQDLGGILGNYMSLGEMNNKNFLQQVDSKIYDLRSRQSAQLASKTKFIEDIDKIEWRSLDQPKDADDEKPIYDISAPIPIDSTATSSTKVFRVELNQSSNGMQIAMGLRDRVKKSKDLKNAWKKFIGIATSKFNGKPGGDSELEKTSDSSDILEKDEGISSLIDDSSGIGAYGGLRHHHHHHRKRSSPPTVPEDGEKPSTSRTITVVRSSSRSSAKEQDSGYMSADSSESKLNGKKIYERFNFSSQPPDGAVEGTIAEENKYEVCAAQESNANCGPSNETYGTTDTAGTNRSGSSSGAGSSGGRGDKSSIARPRSPPPPLPPPNPPPPPPPTATIPSKKAPGSAVKVIEKPHSKPPPPPPSPPTTITTTTIGKLARNEPGSSRQLGPTTNGVFFNTTDAISVRVYSSDDEKFDGSDDASCISDDDDLDSQLDDISESGAESVETHSVFFKNIRKPAHLSVASNADRALAAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZL0</accession>
    <name>A0A084VZL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Dsim\GD14855-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011201</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011201-RA">
        <property type="protein sequence ID" value="ASIC011201-PA"/>
        <property type="gene ID" value="ASIC011201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011201"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15028" checksum="B05F2CB0C059FAC8" modified="2014-10-29" version="1">MRGTGIVRWLDFPVNRAARTVRSAAQIPSDPCAKGERFIVIRFFKCYLRLSSYAPAVRDPRIPATGARGTALRLLRRATKCTNFELTGAETWVVSESDHGPGEAVPCASSSGQYWVIEYVDTSCGNCQQTAKRTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZX0</accession>
    <name>A0A084VZX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003731-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZX0"/>
    <dbReference type="STRING" id="74873.A0A084VZX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011320-RA">
        <property type="protein sequence ID" value="ASIC011320-PA"/>
        <property type="gene ID" value="ASIC011320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011320"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003278"/>
    <dbReference type="OMA" id="MYQEYLN"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF27">
        <property type="entry name" value="LD45836P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="25879" checksum="C18E50B0F19331E8" modified="2014-10-29" version="1">MYQALLQQAINSLQNLSSDELRNLLGDEEKLDERVNEVIKTIDSSKDAIINENRRLAEANLEFEPKMIELRSRVQELGEEGRQAGEVVKKKITELNAKASASNADTVMALLQTAAAESEEESEALVKQFLDGELSTDAFLEQFMGVRKLMHTRKLKAEKMVDLIVKTKGQNLDISTPMPGFHLLNLGQYTPPAPASPAGFDQPPSSSASPAFVPYPVDQSSIPYPLGMFQSPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0R6</accession>
    <name>A0A084W0R6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011652</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0R6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011652-RA">
        <property type="protein sequence ID" value="ASIC011652-PA"/>
        <property type="gene ID" value="ASIC011652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011652"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="260" mass="28398" checksum="6D0C4559247AC341" modified="2014-10-29" version="1">MVCCISEGARLGKWRPATSAQPGTRMFLELGQDKLKSVGAHWMCGRVCVCVWREATCHATCPRDNHAADGPSSSSSASSVSSVYRGMVVKNFFMGTCHGRMQRRGCTGFPSREKAHVTIAIVTVGFGEIGGMEGKTALLEFASSSQRILPRAHDVRPCPRVLFQSPRHIPESAAGVLAKTKTPTPTGPSSAGRTRIHFPSKYNARERLLGVPSIVRPRVIFAESVRTCRTQPAKEGKQVVQPRIQTYSDTRNDEPYGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W215</accession>
    <name>A0A084W215_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP009869-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W215"/>
    <dbReference type="STRING" id="74873.A0A084W215"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012036-RA">
        <property type="protein sequence ID" value="ASIC012036-PA"/>
        <property type="gene ID" value="ASIC012036"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012036"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008722"/>
    <dbReference type="OMA" id="MYKFIFI"/>
    <dbReference type="OrthoDB" id="7255276at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF215">
        <property type="entry name" value="CUTICULAR PROTEIN 49AG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784241" evidence="3">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012036-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13150" checksum="06EC7B341DF26F42" modified="2014-10-29" version="1">MNTLCALVVLATVAAVYGAPAPADSDAQAAIVSQTSDVQPDGSFNYAYESANGIKVEDQGTIKSIKVPKLDETGRQVGEEDVQVSVQTGSFQYTAPDGQVYTLRYIADENGFQPQADHLPVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W449</accession>
    <name>A0A084W449_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP006055-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00012929</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W449"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012929-RA">
        <property type="protein sequence ID" value="ASIC012929-PA"/>
        <property type="gene ID" value="ASIC012929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012929"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011494"/>
    <dbReference type="OMA" id="ITQHLAK"/>
    <dbReference type="OrthoDB" id="273147at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="881"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012929-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1555" mass="175293" checksum="AD307610F9527980" modified="2014-10-29" version="1">MGPDERKLVNKKTKYANQDNYLALAETCQRLGELYKDREEYQRALNEYKLAAKAYEKLNRLMDRGLAFRMIGEMHLMMGQFKEALQNVQAYSRAARNEANQLEIQRANVTLGRVYLHRAESLLLDKKASEAEADLIEAEKAFNVALSICDKLQGTVRKTELIEMQAGTYLNIGVTLDRRGKTGPAQEHMERAIRLAREADSFELLHTCYNTMALSCSQWEKNNDGEHRGKTLRLLNHGLEVASRLSNRSTKMCQTLLLKADFCLQMGDFQSARQTLKRAYHLKTPVSSDAKQIEWQLKVLVAICRTEDELITLEATNYERRKTLYELMGDGACRLRNFAKAIDYYRRMLECAEALGDVNRQLIPCYVSLYQTYTDNQQYDLALEYLWKEYEIIASEPKEAYHTLLQIAKLYERQEKSFFDIEDIYRKARVEAKKLKSIDLERVTIQRAVKMLRKHCMDLMADTLEQEAIAEGIDLSIVEPDSEGLPDMDCLSEVDEDDREDEQNTPNVGDDINLDIDLSDNSDVEGEANLGGGIGSGKKLNDSIPDGLNTSTSAQGRRRKRGMTFAVRRNNKGETQLHQAAIAGNKVLVERLLEQGHPVNVRDHAGWLPLHEACIHGHADIVTTLLDRGAHMNDKGGTSCDGITPLYDACSNGRLEVIEVLLDRGANATQRTDLGDTTLAVLDTWYSKRKARLSPEEIRHYERVRERLVAKFDAVAVQVSPPSAERRSTKKDLSSGRKTMVRRNSYSSDSDTPNDSTAHTTASSSSKVKSLRSTGSSSSSYGSKETVMLNRPHRNTASSSDDERSDPKHVAVNGASDDDFNPVGVSEYRSTMLALRKNKITDHRPTSLSLSGQKKRLAHMTMDEVDADDWLIDDLQQSAKRSRVAPTVLPRSASSSLERKKSSSSFGKTLSSSDFAGVEATPPPPYSTDCASALLDADDDDLPFAEDADPYAHDCWQEQESTDSAFNVLMKNSAKSFRRIQNRRGSSESSRTRRNSLGIAQTSLLDAGFQRVASPLFDEKENLTPPEDGRLKTPVKKTTPTPVAPSPHKSPAVQPPLKQTFHVVLDNGKTLDLCFNDQTLFSTRTIGWLQNEIVKRYIVYHGKRILLKIKQSKDLHAFSESEYLHVLTENGVPGLNAQITVYGMVRGCQDVDFAQFYDEYCEEHKKVNDKNLQTRLIKLERSSSIILEPDFALTVPSQPLPASDTLSFVFLLVFFQQDWLNHLDLSVNGITDKHMETLARYLPSCRQLRVLRLALNLLTSRTVEMLCYGVKDPLDEESLSGSLPVDGLKGSALEELDLSSNPLEDDAIAPLFVLCNELSNLRVLRLGSTDITTIDESNVGNFDISRLETFDVSQNKLHEHSMQYLLNQLCEGRLRDANFHSLAALCTDFKPKLWQTISNTQPGNLRALNLSNCRLTDDEIDQTLLPSLGRNCEKLIHLDLSVNVALTKRTFLSVLRQCNGAVFRLEQLYFRHNVQLWVDLDTIAPEEQLKMIEYNPSIQYPRELLAMLPVGDYTADQHETLLTVVNNLWRTLWSARTTNLTKHDDGLHITLSVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W491</accession>
    <name>A0A084W491_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005663-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012976</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020295">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W491"/>
    <dbReference type="STRING" id="74873.A0A084W491"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012976-RA">
        <property type="protein sequence ID" value="ASIC012976-PA"/>
        <property type="gene ID" value="ASIC012976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012976"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001955"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784353" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10144" checksum="5B2EAA31A05678ED" modified="2014-10-29" version="1">MKTVALLVGLLAVASAEWIDIDWSTVRPIEEFDHYWARLPAELQIFRNRRPSGRVTNGQEATPGQFPYQIALLSEFGAGTGLSVFVSRPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4B9</accession>
    <name>A0A084W4B9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012891</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4B9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012891-RA">
        <property type="protein sequence ID" value="ASIC012891-PA"/>
        <property type="gene ID" value="ASIC012891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012891"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6495" checksum="8624786C7AD5318A" modified="2014-10-29" version="1">MMNKRRPQAEDPLRTPTTFSLTAHNSTCTCRSSHHQIRIKTPPKANDNRNLWQPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W540</accession>
    <name>A0A084W540_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001506-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00013283</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W540"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013283-RA">
        <property type="protein sequence ID" value="ASIC013283-PA"/>
        <property type="gene ID" value="ASIC013283"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013283"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003092"/>
    <dbReference type="OMA" id="CYHPSGQ"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB45334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013283-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="335" mass="37159" checksum="B7B4792915B7FCAC" modified="2014-10-29" version="1">MPPKDDPEIAALKKEINDMIAKFQEEQKKAADCTLFEKCGDLGDVPKVRISTKKFLKGHINKVNSVHFAGDSRHCVTGSLDGKLIIWDTWTGNKVQVIPLRSAWVMSVAYADSGNFVACGGMDNMCTVYDLNNRDAQGNAKIVRELMGYEGFLSSCRFLDDTHILTGSGDMKICIWDLQVGKKTSEFDAHAGDVVSISMSPDKNTYVTGSVDRTCKLWDVRENSPKQTFFGHEADVNSVCYHPSGFGFATGSEDKTARLFDFRSDQQIXXXXXXXSGRYILCGSDDNNIHIWDTMKGQHNGTLSGHENRITSISMAPNGMALASCSWDQHVRIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W579</accession>
    <name>A0A084W579_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001403-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013211</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020514">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W579"/>
    <dbReference type="STRING" id="74873.A0A084W579"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013211-RA">
        <property type="protein sequence ID" value="ASIC013211-PA"/>
        <property type="gene ID" value="ASIC013211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013211"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013111"/>
    <dbReference type="OMA" id="IICHYWY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="22566" checksum="CE727B10573F4ECC" modified="2014-10-29" version="1">MIRLVQWFRTVTKTAFSKKYLLLTNVGISVSLSGVGDIIEQHYEIYTDQLAAWDRQRTRFMSISGMTVGVFCHSWYNFMDRRFPGRTVGLVLKKVLIDQTVASPIVIFLFFATLAALKRSSFDEMRNEMREKFIRLYTAEWVVWPPAQIVNFYFLPTKYRVLYDNTISLGYDVYTSYVINDEIPSEKLEMGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5Q7</accession>
    <name>A0A084W5Q7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013501</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020685">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5Q7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013501-RA">
        <property type="protein sequence ID" value="ASIC013501-PA"/>
        <property type="gene ID" value="ASIC013501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013501"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8001" checksum="256D117702E03FE3" modified="2014-10-29" version="1">MQCTGAKATSFLNCFHLHDPGLSFLPPKAGRQTVDHSNNDRPAPTVDGVVPALPEAVESAFTFSKQQWQHSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5W1</accession>
    <name>A0A084W5W1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP008359-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00013595</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5W1"/>
    <dbReference type="STRING" id="74873.A0A084W5W1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013595-RA">
        <property type="protein sequence ID" value="ASIC013595-PA"/>
        <property type="gene ID" value="ASIC013595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013595"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017145"/>
    <dbReference type="OMA" id="ERMGQVM"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013595-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="664" mass="72764" checksum="904487D15C03CE20" modified="2014-10-29" version="1">MEEDTIVLEDSSVEKVAITTALPLGIDPVAIVSKLVTETTRILTTTTQRTSTMDPSTTSSIPTTSTLETSTFTMGSILDESTTAAPVVEGLLFSWFDYTIFALLLLLSAFIGAYFGFVSKIKQNNTKEYLLGGKTMNKFPVSASLIASHISGITMLGVPSEMYSHGTQYWLFIIPAFSVAYLMKQIYLPVFYDLQVTSAFTYLELRFDKFVRSAASLVYAIQCIIYIPIVIYVPALAFSQVTGINLHVITPVICVICIFYTTVGGLRAVVWTDTLQFVLMIGACLAVIALGISSVGGFFEVWQAAERGNRLIFFNMDPNPFVRTSFWTVCFGLTTLWVSNLAVSQGCVQRFLAVPDLKVAKNSLIIFTAGLIFVKSCSCFIGLLIYAKYETCDPFSTQKISKIDQILPYYIMDVGAKIPGLPGLFVSGIFSAALSTMSSVLNTLAGTIYEDFIRHRIPNASEKTASNTMKMLVVVLGFLVLGLVFVAERMGQVMHIAISLSGVTSGTMLGMFTSGMISRRMNTKGIISASVVSMILTGTVMIGAQLNPKPPMLPLRTDGCDEFLLANVTTILTEATAPDTVPLIFKLSFMHYALLGLVSFFIVAYVVSELTGAGDINDERLLAPFLRNPSKLEKEMTLLKHNIKYEEIDLALRELQKPVDLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5X9</accession>
    <name>A0A084W5X9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013615</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5X9"/>
    <dbReference type="STRING" id="74873.A0A084W5X9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013615-RA">
        <property type="protein sequence ID" value="ASIC013615-PA"/>
        <property type="gene ID" value="ASIC013615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013615"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005317"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000031">
        <property type="entry name" value="Mannose-P-dolichol utilization defect 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="27806" checksum="2E01133B166F2DB2" modified="2014-10-29" version="1">MVDYGKQFMLYLMDEKCYDKYFIDFDLLDGDCFRALLSKGLGMGIIAGSVLVKVPQITKIAANKSARGISLFSVCLDLFAITIHMAYSFVNGFPFSAWGDTAFLALQTAIIAMLVLFYGGSSARSVAFAIGYSALVYVLLGGLTPLNYLLIAQGFNVPILLLGKLSQALANYRNGSTGQLSAVTCFMLLAGSLARIFTSIQETGDQMMIITYGSSSFANLVIALQVLYYWNSDKQKKSAPSKEAAKKPKAKSKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7L9</accession>
    <name>A0A084W7L9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014218</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7L9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014218-RA">
        <property type="protein sequence ID" value="ASIC014218-PA"/>
        <property type="gene ID" value="ASIC014218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014218"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6696" checksum="A856599C2145DDF4" modified="2014-10-29" version="1">MLVMFLNVISRSSIVVCGAINLFVNRSEERERIIPDCHLETGIDFKFVPARGYPGRQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7S2</accession>
    <name>A0A084W7S2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="12">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00014249</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="12"/>
    <dbReference type="EMBL" id="ATLV01021293">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7S2"/>
    <dbReference type="STRING" id="74873.A0A084W7S2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014249-RA">
        <property type="protein sequence ID" value="ASIC014249-PA"/>
        <property type="gene ID" value="ASIC014249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014249"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009923"/>
    <dbReference type="OMA" id="AFVYFCD"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014249-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="364" mass="40175" checksum="622F36AC0B81CC25" modified="2014-10-29" version="1">MVINFGAGPAKLPREVLLEVQKELVEYGTSGMSVMEMSHRGNFYVALHDETLALVKELLDVPDNYKILLMQGGGTGLFAAVAMNLIGKTGKADYLVTGSWSTMAAKEAARYGTVNWVLPKQDKYTGIPARKDWKLDPEASYVYYCDNETIGGIEFDSIPDTNGVPLVVDMSSNMLSRRVDVKKFGVIFACAQKNIGPSGITLVIVREDLIGNAMPITPTIFDFSIIAKANSISNTPPTFIIYVMGRVFAWIKRHGGVDEMYRQSLSKSQLIYDVIAKSDGFYYCPVDAKVRSRMNVPFRVGGPSGDEELEKLFLKGAEALGMQQLKGHRSVGGIRASLYNAVTIDEAKALQQYMLDFLKKHQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8S6</accession>
    <name>A0A084W8S6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CCR4-NOT transcription complex subunit 4</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">CCR4-associated factor 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">E3 ubiquitin-protein ligase CNOT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Potential transcriptional repressor NOT4Hp</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase CNOT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">ZHAS_00014666</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="31 33" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Interacts (via RING domain) with UBE2D2. Interacts with ABCE1, PINK1 and PELO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01021513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8S6"/>
    <dbReference type="STRING" id="74873.A0A084W8S6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014666-RA">
        <property type="protein sequence ID" value="ASIC014666-PA"/>
        <property type="gene ID" value="ASIC014666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014666"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014444"/>
    <dbReference type="OMA" id="MIRNTRH"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000044">
        <property type="entry name" value="Putative ccr4-not transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 25" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 26" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 26" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="29">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="30">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="26">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="391"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="940"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="27">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="520"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KFB46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="984" mass="104740" checksum="A3A26602AA4E24DF" modified="2014-10-29" version="1">MNVMNNSSGDEQAECPLCMEPLEVDDLNFYPCTCGYQICRFCWHRIRTDENELCPACRKAYPENPADFTPLSQEQIAAFKAEKRQRDQQRRAKISENRKHLANVRVVQKNLVFVVGLPPRLADPEILKKHEYFGKYGKIHKVVINPSTTYAGVQGPSASAYVTYINNNDALRAIQSVNNIMIDGRLIKTSLGTTKYCSHFMKNQTCPKPDCMYLHELGDQEASFTKEEMHQGKHQEYEKRLHDAMQAQLGLTSAGGGGSNGSSGTGGSSSAGSGGASNAGVGTIASLVSSIATSTVAAVVAATTAASAAAVAGATGASTAGASSTLVVNGVIAGSAGSGGGSESGIPRSGGGGGGGGIGVTTSGSGSGIGFLGSGKSSAVSDIKQISDITNGPIQNKDAWPSLSTVPVHGSTHGGGGSNKENKLNGKTANGSSSNKENANRNDRKNDSKSRSKGGKNKQQQQQQQQHNKNSHDNSSNHKDSTTNVVNNGGSKQRGNAHEAHENGTTNGKESHHNSKNLKQQRERERERERERERERERERERERERERERDREREQHHQAILNGNHGDEQNPGKKRLDANTNGHIISNDLDDDDDELDFEDLDNDALSSDNDGKTDSPSLSSTASSRNGVDSGSLSETASGKSSPGAFVDTLNNGVDGGVIAASEESETTGDSVANAISPVDGSDVVETNRNSSSPSTSSSSTGDEKVDSDSSAAPTSTATSSLYDKLGSVGGSNPAVTTATSNGSNSSSILSNHKQFASSLLESTGRFGSKLDSILDDNSSFFSYNAFDPYGKQTAAGIAAGATDLGAMVDGVSQQGGNGLTSSQLPDLLSGTNDTNEQHAKELLKNMGNLQLHQAHQQQPQQQQHQHQAHQQHHLFQHVARFQQHFNAGLGGLLGNGDATAAAMLGGATDELEPAMNKCMLRHKYMMEDQHEEWLRLQQQQQQQQEQQKRNHLNNGLNGLPPFHNFNGKPPTPRGKQCSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8X4</accession>
    <name>A0A084W8X4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014576</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8X4"/>
    <dbReference type="STRING" id="74873.A0A084W8X4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014576-RA">
        <property type="protein sequence ID" value="ASIC014576-PA"/>
        <property type="gene ID" value="ASIC014576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014576"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013091"/>
    <dbReference type="OMA" id="ALVYSCC"/>
    <dbReference type="OrthoDB" id="8062551at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="250" mass="28116" checksum="9E8E45116BE311BD" modified="2014-10-29" version="1">MPLMRIFCFRLTVRLGSIIVGGCCMLETLITMIMLAAFGGAKFFKSEALYYEENLHIYNPHAVFVWLIGVCKTSPELFYATIMSCMGLYLPCCGAMMAGAYFMKRYLLVPYILVELLRLVCITLTHVIGMIVIKKSINVGYLIAFTIAGGFALLLLFYLWACVVALMQILKIVRSPEYIAVFGDDPLAPVEPQPTGSMDIFAIEPKNPWNDKGMERMSPAVLTLAPYNGTNMLIDDFRPLHSRYLYNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Z7</accession>
    <name>A0A084W8Z7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP003081-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014686</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8Z7"/>
    <dbReference type="STRING" id="74873.A0A084W8Z7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014686-RA">
        <property type="protein sequence ID" value="ASIC014686-PA"/>
        <property type="gene ID" value="ASIC014686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014686"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002343"/>
    <dbReference type="OMA" id="PIEKICW"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026510">
        <property type="entry name" value="PEX11C_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="21136" checksum="159405CD3F262F64" modified="2014-10-29" version="1">MSQTRATLRLFDDLPMLAYSLSYGYGSKEPDRWMGLIGFVTNLIDHAYYPVDKICWLIEHNLLNVENPTRWDTINSMLWVGSIYLNLMKTIRSFTVMEQHKSCIDKKENETSPAFRMLLIKQRMEAISILRLTLDLVHAGSTLPKGMLWGGCFQTWHVGLIGSISSLLGLYQYVAKKRIVKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W950</accession>
    <name>A0A084W950_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014761</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W950"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014761-RA">
        <property type="protein sequence ID" value="ASIC014761-PA"/>
        <property type="gene ID" value="ASIC014761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014761"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012840"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="681" mass="73581" checksum="E90F08960732C009" modified="2014-10-29" version="1">MQEGKRMPSKGPSSLVSGGERASTTATAAMNGVTPQRVRTDPYSPQSRTTTLSGVTIGGGATAWDKGSDTAEMFQRTAMPVGKSGITAAQDIRPKPIARIVSGADRRRRQMEIILTKRALIELELQLIQLDKEEEEEEDYTEEGQEEFPETLGCGTEALYGEEVHASKPVVQFTSTGCPPAGSGEKGPDSPRDDIAAFLEWRRAIEAKVRASAMAEPVNAPAMAHTLNNHATEKDHATGTAHSTHKEPSHGYTATTSTSYLGFTAQNMRTDLGNTQTHSEHTAHVTSHSSHTSCHGTGTYTLQQTCSNPEMIGESRVDWGEYMEREGGVMRQQLNGNHRKGPAALHSVQDLRGVKGEISVSIEVRPSLDVNVEDFTEAAAPSLLKGCGWSEDGDDDDGDSRMRTQHPISSQIVVMSLPHNNGVSSCTRIGDGTIDELAMPEPLLRNHWIPDGGGYLDRDGGGMQRGETDHIGSDDGFHCKQDDRSGAEESSDGAHWRSRNRQPLQPQSLSTVYRGGCVVVAGLRRRIKSDVGHTSNPPEERRSWCYNPERFHDQRYRNRGPNRTITRPRSKLDAGTSAMEPEKRMPSQGPSSLVSGEERASTTAAAALDGVTPQRVRTDPSPSLSRSTTLSAITAEDEAEKPHTATPVGMSGVRATQDIRPKPRPGSLGGADAAGENERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9M6</accession>
    <name>A0A084W9M6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005261-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9M6"/>
    <dbReference type="STRING" id="74873.A0A084W9M6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014930-RA">
        <property type="protein sequence ID" value="ASIC014930-PA"/>
        <property type="gene ID" value="ASIC014930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014930"/>
    <dbReference type="OMA" id="HEQQMAR"/>
    <dbReference type="OrthoDB" id="10038194at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026094">
        <property type="entry name" value="GPS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654:SF2">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15991">
        <property type="entry name" value="G_path_suppress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="414" mass="47604" checksum="94464757005C4FEE" modified="2014-10-29" version="1">MSAKKYLKMPAQQPAQPAAKTEKEEQLWNALKRHIMRERERKKQEMEAEVEEERLRREREEREKQDVMTLGETKEQILILEKNLDDLRNEKQQLFLQLKKVLNEDDNRKRQMKEEMFAIQNIPQQIFLPQRSMHQPHQHLMHKVSPPEVVITSDRIFNDAYPNLQGNPQVNAAKRTHSPSSPQHIQGYYKQPNLNNQPYLQPQKSQYCPPVGFYQATIPSNPQDGHGRQPQPQILYPYQSNLTLPMRQYVDLPSQPGSLMQTKPEQLMSGKVGPPPTQANIYHINLDQTAAVLHGQPPGPPPQLKTITIEKLPQERIVPYHIELAKLDERKDLRPSHIPPPPQPGLVATHLPDGIVYAPPGLRPGAIQMHAIATNQQLPKSGSITQGYPPARPPHISNPQQPPPSQMHYNRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAP6</accession>
    <name>A0A084WAP6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010902-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00015320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022232">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAP6"/>
    <dbReference type="STRING" id="74873.A0A084WAP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015320-RA">
        <property type="protein sequence ID" value="ASIC015320-PA"/>
        <property type="gene ID" value="ASIC015320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015320"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020499"/>
    <dbReference type="OMA" id="EHQPLYH"/>
    <dbReference type="OrthoDB" id="6630852at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF2">
        <property type="entry name" value="MIP24391P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784722" evidence="3">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="235" mass="25548" checksum="98ED2F810CE37196" modified="2014-10-29" version="1">MAFKIVVLFATLACASAGYVQPAHEHLSYEAAPVAHYSSAPAVSYSSFTRQDSPKLAVAKTLSYAEPSVHYAAPLTKTYAVHEPALKTVVAQPAYTKTVYTQEPAHVYAHAAPVVAAKTVSYAAPQVHYQAPLLKNVEYTKTLAYAQPTYTKHVVAEPAYTKTAYVSQPTYTKTAYVQQPTYTKTLVAEHQPLYHQSTPVYAHAAPVVAAKTLSYEPAGHVSHVSYADNSAHYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAY2</accession>
    <name>A0A084WAY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAY2"/>
    <dbReference type="STRING" id="74873.A0A084WAY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015621-RA">
        <property type="protein sequence ID" value="ASIC015621-PA"/>
        <property type="gene ID" value="ASIC015621"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015621"/>
    <dbReference type="OMA" id="QYRKKSH"/>
    <dbReference type="OrthoDB" id="6344011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015621-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="201" mass="22270" checksum="21C7385E32BA9F7C" modified="2014-10-29" version="1">MGCGPSNAAVPVAGEGISTISKLVYPRPEAFEIPLDDNGENAGSLIKKHPPKRLKRLEEQHSSSPSIEDLEEKLATAEIRRQQFLANRSQKTTFDKGSLDATENDASTIPEEGEDDRSAVDEHMLEDTEDSGVERTGPPDGSDSPKNTRHRGRKGESEEGENEEDGDAAHNQRRRGSDLSIGHLTSMRMRMNQYRKKSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBM1</accession>
    <name>A0A084WBM1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004917-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022371">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBM1"/>
    <dbReference type="STRING" id="74873.A0A084WBM1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015587-RA">
        <property type="protein sequence ID" value="ASIC015587-PA"/>
        <property type="gene ID" value="ASIC015587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015587"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002100"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784636" evidence="1">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="43016" checksum="5CAD69D9409E37EC" modified="2014-10-29" version="1">MPLTKPLLCVILCSLVPLGWAAEVEATADMPTVVEAIIHAMINFRKEILDNLQLSLEYHTEQLEEIKSHVDHEIAKLNTQCVANYEMLHARNIASESKLKKLQKATKRFLNESSSQIYKIDQTLVEIRRQMVPKSCDWVEYNSTGIFKINPFKNVAKAFLVLCYIDNTFDLGGDWTVFQRRFNGSLDFDRSWEMYKHGFGDVTGEYWLGLEKLYVMTKSGRHELLVLLEDFEGNLAYTLYDEFKVGSEKKKYMLTLGRHSGTAGDSMKLSRGVKFSTLDQYNFGWGGVEKVATSNERSWWIKTISGRYINHTKMYSVSYRILMVFFFFCSHLNGPYFKKGEHKKIGMSWDTFRYPQSLKSATMMFRDHTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC38</accession>
    <name>A0A084WC38_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015855</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015855-RA">
        <property type="protein sequence ID" value="ASIC015855-PA"/>
        <property type="gene ID" value="ASIC015855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015855"/>
    <dbReference type="OrthoDB" id="6435011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6646" checksum="E3CC571FC5DD628D" modified="2014-10-29" version="1">MVVVVGGSGGGGLRKQRHNRSLHAECLSEAEGIDGHDSGTESDGDLEQEDDLIQEHEMELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCW1</accession>
    <name>A0A084WCW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004918-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Lectin involved in innate immunity. Agglutinates all types of human erythrocytes, Gram-positive and Gram-negative bacteria. Has a stronger agglutinating activity towards Gram-negative bacteria than towards Gram-positive bacteria. Specifically recognizes acetyl group-containing substances on agglutinated cells. The hemagglutinating activity was inhibited by EDTA, acetyl group-containing mono- and disaccharides, N-acetyl derivatives of amino acids, other acetyl group-containing substances, propionamide and benzamide. Enhances the antimicrobial activity of big defensin against Gram-positive bacteria but not against Gram-negative bacteria.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCW1"/>
    <dbReference type="STRING" id="74873.A0A084WCW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016178-RA">
        <property type="protein sequence ID" value="ASIC016178-PA"/>
        <property type="gene ID" value="ASIC016178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016178"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013517"/>
    <dbReference type="OMA" id="WISITRE"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="266" mass="30260" checksum="F480502CFF9EAC2D" modified="2014-10-29" version="1">MSKLQVLEYDMMQKDQQSKEMINSLSSNVANLLKSVEQLTGLAQPLLSEILGSNYTSCKMRPLLDSGVYQIQPEKPFKKPMSVLCDQNYMSGGWTVMLNRFDGSVNFYRGWQEYKNGFGSLEGEFWLGLDRIHQLTASKPHELVVLLEDYDGNKTHAKYNLFEIGDEGQKYALKSLGGYSGTAGNAMNDLVGMHFTTLDADNDVWNKNCAVSFTGAWWYKDCHRSNLNGKYLRGETKEFATGMVWQPFRGYHHSLKTAKMMIRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD88</accession>
    <name>A0A084WD88_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016251</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD88"/>
    <dbReference type="STRING" id="74873.A0A084WD88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016251-RA">
        <property type="protein sequence ID" value="ASIC016251-PA"/>
        <property type="gene ID" value="ASIC016251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016251"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011349"/>
    <dbReference type="OMA" id="QPQHQRW"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000018">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000021">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 11" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="14">
        <location>
            <begin position="138"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="376" mass="42892" checksum="E4288C0F5BE2C477" modified="2014-10-29" version="1">MPNWYYDKKDLRNTPSARDGVDYETERRYRKEGARFIMEAGASMSLGHNTVATGVVYFHRFYMFHSFRTFPRFVTASCCLFLAGKVEETPKKCKDIIKTARSLLPDEKFQSFGDDPKEEVMTLERILLQTIKFDLQVEHPYSFLVKYAKSLKGDSAKLQKMVQMAWNFVNDSLSTTVSIQWEPEIIAVALIYLASKLSKFTVVDWVGKQPEHLKWWDMFVQDVTMEILEEICHQVLDLYQPTQQANAPPDSPPQLPPSKASPPMKRANISPITNKNSPNMSVKTPLPPLPPAEIEANPIPKHITTDTGSHYPYPPYPMHPAPPMPPQTHGPPPPYGPAPMPPQPPQAWQHYQHPQHVNKYYPPGPPPGRNSYYPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE78</accession>
    <name>A0A084WE78_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00016830</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01023193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE78"/>
    <dbReference type="STRING" id="74873.A0A084WE78"/>
    <dbReference type="ESTHER" id="9dipt-a0a084we78">
        <property type="family name" value="Juvenile_hormone_esterase"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC016830-RA">
        <property type="protein sequence ID" value="ASIC016830-PA"/>
        <property type="gene ID" value="ASIC016830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016830"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003943"/>
    <dbReference type="OMA" id="WIHENIL"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010751449" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="52"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016830-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="594" mass="65835" checksum="82CCE34AD3BF97A1" modified="2014-10-29" version="1">MARVVVLFLFLVVHCVVSCTSSGSKEGSPLIAASRKSNASSCHSKEQLRPPRVCIGDGCLQGTFMDGLKAGPFEAFFGIPFARPPVGELRFANPVPNDPWTEETYNATSEKSMCLQRNDLLVDPTVQGSEDCLYLNVYRPKGCDNSTRKLPVMVYIHGGGFFAGTASPWVVGPEYIMDTGRVILVTIQYRLGVLGFLSTGDAAAPGNFGLKDQTLALQWVQRNIRHFGGDPRLVTIFGQSAGAASVHMHMISPLSRGLFQRAIMMSGNALVPWNIPTENPLTLARATARVVGVEGSEKLSTRKLIEALQTVPGEKLVATTKQLKAWSIDPLTLFRPVVESRNSPVSFLVDKPTVSWQNGEYQQVPWLAGFVPNEGAVRALAIFKNEKLLSELKSNFTTILPILLERPPSTTLFDRVRSRFFKDSTSAEPIRSEDLQSFVDLYSEAAFTYPIQLGVKQYAAFADTVQAPVGVYKFSFKGRFSYSAIYAAGDTGDYGVVHCDDLNFLFRSPAIFPDYPAGSPELRMVDTFVNFFIDFAINGRTTPLAPYRECKNENQIYQSMDCDVQEFTRDGDNVKVKVFNGRNEDMFAFWKDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE87</accession>
    <name>A0A084WE87_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00016840</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01023195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE87"/>
    <dbReference type="STRING" id="74873.A0A084WE87"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016840-RA">
        <property type="protein sequence ID" value="ASIC016840-PA"/>
        <property type="gene ID" value="ASIC016840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016840"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017123"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="346" mass="39548" checksum="8735068455723904" modified="2014-10-29" version="1">MAPQLLPGPSGELIVKNAKYVTVHESAIEKLADRVILGIKDKEINVENFSQHEHHPAAKDPNAVNWIFLIDTLNFCFWTPGHDATKWKVEGQTGYFALCAAINRAMREGIDMTNPAFYVSITLEQMEKILRSDNPDTKAPLLEERVRCLHEVGRVLLDRYDGLFENCVRACNGSAVTLLQRVVDEFPCFRDDAILKHGENDSIETPVTFYKRAQILVGDLWSCFRGEGLGKFDDIDAITMFADYRVPQVLVHFGTLSYSEQLMALLKKDKLLENGCREEMEIRGASIHIVERLKVVTREKLIANHPDIKPSCVNAILLDHFLWDYRRKHAAELEYIPFHKTISVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE89</accession>
    <name>A0A084WE89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005475-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023195">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE89"/>
    <dbReference type="STRING" id="74873.A0A084WE89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016843-RA">
        <property type="protein sequence ID" value="ASIC016843-PA"/>
        <property type="gene ID" value="ASIC016843"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016843"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007369"/>
    <dbReference type="OrthoDB" id="7744882at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="281"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016843-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="409" mass="44134" checksum="FFDE286483FBFA85" modified="2014-10-29" version="1">MDHQKRSQPSLFRFNAASPSRIPASGDIVRPWEASSTRIPLITASPSHAMAPPPSTAPSPSTTQPLRLPPPVPRFTAASSTVSPASPALTGSASQLLQMPPPVPRFTAASPSPSPASPALTGSASQLLQMPPPVPRFTAASPSPSPALLDYENAPCTSASQGSSYIKRREGVIHNSGTSPLPILDSLERLEADPDPFDFGPPPKRHLSSAAVPNFSPLPHPDPVPSPPLRPAVECSCQGELREEVRILRKAVINLQVALEQTGELMTVHRSATRPSNFVKLETREQLDEFEGRLGRDASFVAEMVAHLKQGIMSLDPKNRIARVIDSLFSRRLFAECSWTGVGRPNPKIPFVQLVNIFGLITRVAGNENPAASDFVEAVLRSRLNSAPKRVNRETGRLAYCKLKTKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEL2</accession>
    <name>A0A084WEL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLD phosphodiesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016651</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023221">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEL2"/>
    <dbReference type="STRING" id="74873.A0A084WEL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016651-RA">
        <property type="protein sequence ID" value="ASIC016651-PA"/>
        <property type="gene ID" value="ASIC016651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016651"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019628"/>
    <dbReference type="OMA" id="SAWNVKE"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048481">
        <property type="entry name" value="LRIM1_APL1C-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20733">
        <property type="entry name" value="LRIM1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="425"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="486" mass="55439" checksum="2B46C6E53D47EFFE" modified="2014-10-29" version="1">MVQGQVFRVYETPRNSGIFKIESVVDGDLRNALRSINTPWNVKSLDLSGNVLSKINANDFMGFNSLQELKLDSNVITGEVDVRSLRIVTLDVSNNFISRVVVGPSLKNLHATSNNITTVSCTGSQQGKKFHLDSNKINSLTDLSAPCRQGLEVLNLELNDIDIIDFAHLYESRDTLVTLNLGLNFIYDVKNSNAFEFVFRNLAKLDLQNNKIAFMSGALNAANNAEINLSHNKLVLIDDNLKVLVNKFDLRGNEFQCQTLHKYFTKAPNKSIAPKYVDEKCTKNLKGICCEDLNAPFADRLIALKRREQSLFKQGNEAEEQKQCEKENALRSQRLAAIVQKYNLQVKLADQQRREKATLNVTKYELEGKLKEKEEIIHALTELLEAEAKNLDLKYKENTLEMIDEIVQYYEDRYNAEQNKQRQAIKDLESFQKMIEQQLEEKERLEKLNLDADFALQKANATLTELKEKQAQLTKTLAERTPKNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEM8</accession>
    <name>A0A084WEM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006158-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016669</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023229">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEM8"/>
    <dbReference type="STRING" id="74873.A0A084WEM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016669-RA">
        <property type="protein sequence ID" value="ASIC016669-PA"/>
        <property type="gene ID" value="ASIC016669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016669"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009773"/>
    <dbReference type="OMA" id="RYRSETM"/>
    <dbReference type="OrthoDB" id="5578278at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="395"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="631" mass="72193" checksum="2AC669A3BFC9D73B" modified="2014-10-29" version="1">MLLNFGQCNRKHPPTLLPLAMRNRALRSEKTPNGRMLANVLTSCEVLLHNLDAYMQSNAASPAVSILPGTEKLAPGVTGRSQPNYYGKSLLTGSASSSSSSVTLYGSAGGNRQKVKIERQMDAIQSEIAKTLPKERLLPIVKEYGEYPAKHRPTIWRTLLELPSDAESFGALLQRGHHPCVASLDERRFPSQDSRTVRNVKKIVSCLAHWCPVFGLIDYLPYFVFPFVRQHPNDALVAFETVATVLLNQCQLWFEFAPLEPWNYLAMVENVLAEFEPRLMSFYRSHGTGTPSTNEESITNFFHQSSSVDVRRVVRRAYDLMERCPDAIHPRNYFKSFVLLSGNNAIDFTRPRRETPSSEGGTSIDVYWPSSSVTEGYVNFCNFPKALTDVRCTETNALQAEQRRLEAKIIELEKLEHSLKDRMVNNLIRQEHEERVKKVEQNFEEAISREEQRIEMQRKLLLLHRKQLRERESELSLDLHNAKLINDATRQREETDLLFAEEDIKLKELELLARYRSETMPPPALGSATSDECHRPDHPRYQQALEQLAVQKQKLYDEIDRTYSSLGMPIGSNEYTYRTVTELRKVASVASNERYPSKVRNHPVKEQQPPESRPIHAVTSQVKVCKLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF78</accession>
    <name>A0A084WF78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001033-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023315">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF78"/>
    <dbReference type="STRING" id="74873.A0A084WF78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017133-RA">
        <property type="protein sequence ID" value="ASIC017133-PA"/>
        <property type="gene ID" value="ASIC017133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017133"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013687"/>
    <dbReference type="OMA" id="WDESCIA"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="253"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="365" mass="41720" checksum="44EBD14636236A3D" modified="2014-10-29" version="1">MLVPPDMVTVQSKTIFQINKYYAEKVQVRMGNIAIVLREICKIVQEVLREVEVQEPRFISSLVECNGRFEGLEVISPTAFEVVLYLNQMGVFNFVDDGSLPGAAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFHTLVAQAVEKCPYRDMVKLVPDTTEVKLKIRERYVVQITPAFKCTGIWPRSAAHWPLLNIPWPHPALVAEVKTEGFDLLSKESVILQGKNANIEGDAWLLHFTEAENRLLQGGYRKRCLSILKTLCDRHLELPGAPINYYHLKTLLLYECEKHPREAEWDANCVADRLNGIFLQLISCLQCRRCPHYFLPSLDLFKGKSPTALDNASKHVWRLCRDILTSSKAFDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG83</accession>
    <name>A0A084WG83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP009781-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023462">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG83"/>
    <dbReference type="STRING" id="74873.A0A084WG83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017232-RA">
        <property type="protein sequence ID" value="ASIC017232-PA"/>
        <property type="gene ID" value="ASIC017232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017232"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011755"/>
    <dbReference type="OMA" id="GYSCTWD"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19862">
        <property type="entry name" value="DSRM_PRKRA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19863">
        <property type="entry name" value="DSRM_PRKRA-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19864">
        <property type="entry name" value="DSRM_PRKRA-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="165"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="310"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="382" mass="42416" checksum="98FB2052168F8334" modified="2014-10-29" version="1">MNMNSHIDLNQHLAQQLTDPPISRPPPAGGVKKSGRNKKIAQATGLSVPLEEALKMELTTNNMKTPISVLQELLSRRGITPQYDLIQVEGAVHEPTFRYRVSYQDKDAMGTGKSKKEAKHAAARALIDKLAGSNFHDLTGGHLPVTQENLGNHNANGGEDEPTGNPIGWLQEMCMARRWPPPLYEMEMEEGLPHERQFTIACVVLKYHEVGEGKSKKIAKRQAAQKMWQRLQDQPVEPSQTMQLLDDDGNEELRPTGIGGRFAGLKDAGIPSLTTAHSQKVSHFHKALKSRCGEALTKLKQTSLSDRSTNFKALLDEIANEQRFEVTYVDIDEKTHSGMYQCLLQLSTLPVAVCHGTGKTILDAQMHAARNSLEYLKIMTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGF4</accession>
    <name>A0A084WGF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Concanavalin A-like lectin protein kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017413</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017413-RA">
        <property type="protein sequence ID" value="ASIC017413-PA"/>
        <property type="gene ID" value="ASIC017413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017413"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8366" checksum="2869D4D771767254" modified="2014-10-29" version="1">MELSGLHEWKHNKKDLQTEERHNMQHRFDLTTGLFPNTAGTGFGRKPIEMRTPVVNFSPHQGRKLVQSGPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGH5</accession>
    <name>A0A084WGH5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017436</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023571">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017436-RA">
        <property type="protein sequence ID" value="ASIC017436-PA"/>
        <property type="gene ID" value="ASIC017436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017436"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14616" checksum="555B2250E53C0930" modified="2014-10-29" version="1">MSFPYLVPFGTVVQFNITPGTFVSIKAYFKADHTWEIRYRKWRGSVTAHRCHNTYSGNAKRRWWSHSPYRTPFGVTAGIHTLALVKTVILKHSCGPLARAGGQAIAARDRATRSSERLVEVAIVSTPADKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHJ5</accession>
    <name>A0A084WHJ5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant-binding protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018070</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHJ5"/>
    <dbReference type="STRING" id="74873.A0A084WHJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018070-RA">
        <property type="protein sequence ID" value="ASIC018070-PA"/>
        <property type="gene ID" value="ASIC018070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018070"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004336"/>
    <dbReference type="OMA" id="QCVAQCF"/>
    <dbReference type="OrthoDB" id="8194482at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF9">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784739" description="Odorant-binding protein 29" evidence="9">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34388" checksum="94A26351E9F9BC65" modified="2014-10-29" version="1">MTWKRVATVVIGVSVLVLLAGTLRPVEGLRCRTNEGPSTEDVKRIVQTCLNKITNGGENRSSDEYPNYDSSYSDDSSEEQHRKGEGGKMSGSRRQTNPGDRRMGRPEEGTDRRQMDGRGQRNGRPRMNQSQDRGQRDRYGDDNMMMMRDFERQQHQRSKRQYYSGGQGPPMSGGSGGDFSNNFGHNTPAQQSNTGNGSRSGNSSLERDRACLMQCFFEELKATNAEGFPEKHKVLHVITKDIRERELRDFYIDSIQECFRMLGMDNRLKDKCDYSMRFVTCLTDRFQSNCDDWDVDTSAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIH4</accession>
    <name>A0A084WIH4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transglycosylase SLT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018061</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIH4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018061-RA">
        <property type="protein sequence ID" value="ASIC018061-PA"/>
        <property type="gene ID" value="ASIC018061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018061"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018061-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5843" checksum="0A8AA91F0742D231" modified="2014-10-29" version="1">MTPSGVPGGGARVSARSYPSAPARHLFSRFENVFLHQNPKKTCRTSDPAQSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJI1</accession>
    <name>A0A084WJI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJI1"/>
    <dbReference type="STRING" id="74873.A0A084WJI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018649-RA">
        <property type="protein sequence ID" value="ASIC018649-PA"/>
        <property type="gene ID" value="ASIC018649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018649"/>
    <dbReference type="OMA" id="PKKICEV"/>
    <dbReference type="OrthoDB" id="7762889at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39942:SF1">
        <property type="entry name" value="BCDNA.LD26519-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018649-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12934" checksum="4B34A3EB45E485A2" modified="2014-10-29" version="1">MERIVDCNQLQQFLNYCRLCGADNPDKVPIFEEDEELFGDVAPLWKKIEECVAIQVCKNDQMPQEICLQCIDKVNDFFEYRAVCAATDSQTRAILNVAPDEPESVMVKTIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJZ0</accession>
    <name>A0A084WJZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018576</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018576-RA">
        <property type="protein sequence ID" value="ASIC018576-PA"/>
        <property type="gene ID" value="ASIC018576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018576"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="13858" checksum="E7512AB5C1A08101" modified="2014-10-29" version="1">MEMAPSTFTSPICSGYVRVRRPKPDGSAAANEREINAPSLAMATGGRWRLLPVLRGGTELEDTVVAMANPLADTSPKALHTDGFGVARSYHDSQIRSPVSGDNIVAGRTGGPPPECPEQTFATGQGCEGTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKU8</accession>
    <name>A0A084WKU8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005201-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKU8"/>
    <dbReference type="STRING" id="74873.A0A084WKU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019067-RA">
        <property type="protein sequence ID" value="ASIC019067-PA"/>
        <property type="gene ID" value="ASIC019067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019067"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016447"/>
    <dbReference type="OMA" id="CYTFNEM"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="236" mass="24836" checksum="E2E2EF669F4FD881" modified="2014-10-29" version="1">MAVNMYGAMQNHPPPNPNPTDLMAIKDIYPGLKNINVIFIILEIGPVTLTKENREVRTFKVADQSAAINVSIWDEPGKQLAPGDIVRLTKGYASIWRQCLTLYSGKNGEIVRLGDFCYTFNEMVNMSEPNPNLSAPLPQPILNNGGGPNSGNNNNNGTGKPSKPVANSSPLHSGGSGGGGASSTKPHTATTRFSVAAAAAAAAASPPSTMKPSPKNAPRTGRNSQAKSSTVKSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLM2</accession>
    <name>A0A084WLM2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP006704-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00019175</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLM2"/>
    <dbReference type="STRING" id="74873.A0A084WLM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019175-RA">
        <property type="protein sequence ID" value="ASIC019175-PA"/>
        <property type="gene ID" value="ASIC019175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019175"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005079"/>
    <dbReference type="OMA" id="CCAFNYH"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB51116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="601" mass="68551" checksum="12381154201AADE6" modified="2014-10-29" version="1">MRWYKNEPPLISSRNADLNTSGFGFPSEGRRLQCVMKIRRALLAARETVRYVARNFCENTSLHGLRYVYGGERTEHPNGRMLRTMWLMVCLVSIGFTMVMGAIAWTRFRTTPTITTIETMTYPIWNIHFPGVTVCNINKVDKRKAKVIVDRLVREFGLSEVNATGLLVAQASLINFEQTNLSFIELEAVLGQMGWNPNRLLLELSQPCSELIKVCYWLGSEVPCAQVIHRTKTDNGFCCSYNVDQAMQPLVARRNGDSTDQGAHHGPYRPQRLSGAGRHVGLSLLIDIEPDTYMAPTKSFYGAEIYVHDSMDFPSDADFEHVAQPGWDVVMSVIPLPIESSSTMRQVPEEMRKCFLPEESSEKQHAEMNLNVCLAQCRLRTILKLCNCVPFYYADLRYFYSLRPDSQSEADLTDVEFGMDCDCMPPCSVLNYNVETITSQRLSKEFVSSQFGGRNVSQYATLNVHFKDIYCVKYKRDAYMTWDSLVATFGGIFGLCMGGSVLSLVEMLYYFTVKPFTAYRRAHRGKRSGNRTKTSSRRHPPIAVRPYDGQRFPVGYFLRRNVLARSKDVMQQRTNRGQFSWSVEKPPKQMPEISDGLSFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLU9</accession>
    <name>A0A084WLU9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019456</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLU9"/>
    <dbReference type="STRING" id="74873.A0A084WLU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019456-RA">
        <property type="protein sequence ID" value="ASIC019456-PA"/>
        <property type="gene ID" value="ASIC019456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019456"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="9922" checksum="73CB75BA276E3057" modified="2014-10-29" version="1">MSPVSPVPSAHTQLMAFKLNGGGGGGGGGLVGGGGMNNGFFGPGIHDGAGGIAGNGNVAGLLGGGSMMSPGGMLGIVSGDYIDLNELLSMDGNGGHDEDNSSMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM95</accession>
    <name>A0A084WM95_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019397</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM95"/>
    <dbReference type="STRING" id="74873.A0A084WM95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019397-RA">
        <property type="protein sequence ID" value="ASIC019397-PA"/>
        <property type="gene ID" value="ASIC019397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019397"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004064"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="425" mass="49622" checksum="94C5ADD3F91EB0D7" modified="2014-10-29" version="1">MIKLVVNPANKAAKKHVSRKLKSSWRKHIDTTDIDNFLEEKRQDERIGTVEEKPDAELFTEETKPSRPKLTQRELRKKKFHEMPRSHLTLKNTSQVTDPIVKRNIKAPQDPNAKRTIKAPKAPVASVPRRTRLRKVKRSLVHAIPSKDLWEEEEKLPEELRSEWVEQDLLLHTMKNVGKPLILNQPHKMDIAYKVASEKKHLPREGISYNPAIDDYIQLKNEVVEQEKAILKRKAHFDRVVTNMFTKVTDEEKQRTYQRELTEGLIKSEHSEEEDEDEDTSEEVAKVTLGKRRKKISNAKKQELYHRQFNAKKLKQELAKLKEINRIEEISEEINELEQKVEKKALKRANAPSPTIELPLDFIDPEHLAGNLRTITPLNNLMATGLPKVRKVSIFRYSRAELARKKKRPKKKVAFVRPSHKITDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNY3</accession>
    <name>A0A084WNY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP013186-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNY3"/>
    <dbReference type="STRING" id="74873.A0A084WNY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020090-RA">
        <property type="protein sequence ID" value="ASIC020090-PA"/>
        <property type="gene ID" value="ASIC020090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020090"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010294"/>
    <dbReference type="OMA" id="RWVFIAM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="275" mass="31086" checksum="5738CC28B22C91D3" modified="2014-10-29" version="1">MEQYYYDRHLGITVYDSVLHLTILHNPTSVQIGYNRINELHMPTDLQMGEFKQNSISNVLTNSSLSYAVTYLDLQGNTIGDVSNLSALVNLQTLNLENNNIKEINAQIFAGMHNLSMLYLGYNGFQKLEFKDFPKALTNLWLFNNHLNNLDLVNVTLPSLTVLDLESNNLKTIDLVAVFAAFPGLQFLPIAQNDFAVSEAKRIIAELARHNVTHYFGEPEGFCDSSEFEVSKICFPGSVLIGRSVWKALVLLVLGVIVVAMFVGSVRWIWFQMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP25</accession>
    <name>A0A084WP25_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020138</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525361">
        <property type="protein sequence ID" value="KFB51969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020138-RA">
        <property type="protein sequence ID" value="ASIC020138-PA"/>
        <property type="gene ID" value="ASIC020138"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020138"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020138-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7073" checksum="C31B6FFCECDC6B73" modified="2014-10-29" version="1">MRWRKQDDCLVPHQHTGSRAGAGRLLLFSLAMPGKSPKQWRARHPNETHTSSDRPPDEGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS30</accession>
    <name>A0A084WS30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein toll</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021321</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021321-RA">
        <property type="protein sequence ID" value="ASIC021321-PA"/>
        <property type="gene ID" value="ASIC021321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021321"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004797"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12455" checksum="C0A7273DF7FC2633" modified="2014-10-29" version="1">MASDGIRNHPHANRTTRIIIVIIITIVERNERVAMMLACVEQGFDLFDFELVFSRERTMVARPASLREKRAVIDVGNSTSCRRNGSMLVPPWAPLAAGKDRTIGSSRCQSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS66</accession>
    <name>A0A084WS66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011697-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021353</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525410">
        <property type="protein sequence ID" value="KFB53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS66"/>
    <dbReference type="STRING" id="74873.A0A084WS66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021353-RA">
        <property type="protein sequence ID" value="ASIC021353-PA"/>
        <property type="gene ID" value="ASIC021353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021353"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000303"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="22770" checksum="7E99453035F8FCC8" modified="2014-10-29" version="1">MFQHRLANLLLDHGANPLLANDDNDVALNWALMYPNHPAIAHDAIDRCLRHELRNEQGKTMLELTPRMQEGLINNAVLNGRSDIVERLLGLGVDVSVPAEFGITTAHCAVLVPLHTSYRMLKQLLDYDHSLLYKKDIAGRTILHCAAEVESAEMMDLIRSYDSSLPVLPIGFLSPMMQELSKNNWKWTKALAEIMSADSSENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSF7</accession>
    <name>A0A084WSF7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSF7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021450-RA">
        <property type="protein sequence ID" value="ASIC021450-PA"/>
        <property type="gene ID" value="ASIC021450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021450"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009776"/>
    <dbReference type="OMA" id="LMMRYRN"/>
    <dbReference type="OrthoDB" id="7684978at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785163" evidence="2">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021450-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="25640" checksum="A734E10C9BD64AB9" modified="2014-10-29" version="1">MLLLFVLCIVRYVEPAIAGDRLVFHVPITYKNVHMTKTRHVPEIINRHVHVKTKYMHVYHPKKIVQEMPPTFPEQQQHQQLIDPASMWMPSGAMAAAAPPLAPTPAMAAAFSSMVQEKLSSQLAQELMMRYRNLETPASSALGESAASESDYLRDYYRQQRKLSDQLMLQEAMQLPNFAQTKYLSSMGWDWDKSFGVKPSDAADQPLPVKKSKKKKKDFKTYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT75</accession>
    <name>A0A084WT75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP004569-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00021861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT75"/>
    <dbReference type="STRING" id="74873.A0A084WT75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021861-RA">
        <property type="protein sequence ID" value="ASIC021861-PA"/>
        <property type="gene ID" value="ASIC021861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021861"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018769"/>
    <dbReference type="OMA" id="CDCVCGV"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785187" evidence="9">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="51"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="296" mass="32216" checksum="9E9E13633AAD7C71" modified="2014-10-29" version="1">MIMNRSSSVHLMAIWLLLLAVLSGQLLAAPASNSTGSCDCVCGVGGRTNRIVGGSETPAHQFPWLVGLFRQGKLYCGASVVSRNYLITAAHCVNSFEPSEIRVYLGGHNIAKDYTELRRVKTIIDHEDFDIFTFNNDIALLELDKPLRYGPTIQPACLPDGSVMDFTGTLGVVAGWGRIEEKRAPSKTLRSVEVPIWSQEQCLDAGYGSKKISANMMCAGYHDGQKDACQGDSGGPMHKMGQSGSMEVIGVVSWGRGCARPNLPGIYTRIVNYLPWIHAKLADECLCPPKDVARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTR7</accession>
    <name>A0A084WTR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021851</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021851-RA">
        <property type="protein sequence ID" value="ASIC021851-PA"/>
        <property type="gene ID" value="ASIC021851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021851"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11913" checksum="9A50B35729BE1388" modified="2014-10-29" version="1">MFTLSKSEFSRRPKPSLGHLHGLRTLWRRQVAEKGMQCPPSRSRLANEKMAAENARSPSPFLTASSYGLGGRIWVGGKWGGKYFIVDRAVRAEGGKGGSERVLVLLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU55</accession>
    <name>A0A084WU55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cytochrome oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022129</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022129-RA">
        <property type="protein sequence ID" value="ASIC022129-PA"/>
        <property type="gene ID" value="ASIC022129"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022129"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022129-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7995" checksum="CDAEB795D9A161C4" modified="2014-10-29" version="1">MTNWTPASKPSFPREQKMPLLEIYTIVRNGAGRGWKYLEKFSRPTKANAFKAHSLARDGSTKRRRSSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU60</accession>
    <name>A0A084WU60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nuclear elongation and deformation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022135</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022135-RA">
        <property type="protein sequence ID" value="ASIC022135-PA"/>
        <property type="gene ID" value="ASIC022135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022135"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9625" checksum="45C12B3AA8731068" modified="2014-10-29" version="1">MLTLTDRSPASSSGNQMIPLHCHYAWCIVHARESWWIVYVLWVQLHNAQHHRLQQAILGIDPTPPPTVLHHRVEPEGESSEGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUU3</accession>
    <name>A0A084WUU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Amiloride-sensitive sodium channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022239-RA">
        <property type="protein sequence ID" value="ASIC022239-PA"/>
        <property type="gene ID" value="ASIC022239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022239"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13219" checksum="D93977768E612190" modified="2014-10-29" version="1">MDTVIPKRANARNGVHHNASTMPTIERDRQSTYVRSRPGLPGIEIKDTQSPPSGSTRPESHSPTTAIHVPWRIRCTVFHPPACFFSEGFRVVSGSSSAANELDGNDSPKRYRLLPKRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA26</accession>
    <name>A0A084VA26_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00000285</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01001350">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523960">
        <property type="protein sequence ID" value="KFB34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA26"/>
    <dbReference type="STRING" id="74873.A0A084VA26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000285-RA">
        <property type="protein sequence ID" value="ASIC000285-PA"/>
        <property type="gene ID" value="ASIC000285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000285"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020457"/>
    <dbReference type="OMA" id="NEWIAKW"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="9026" checksum="04ADB0B679C76361" modified="2014-10-29" version="1">MTYEPKTAPFDPRFPNQNQTKYCYQSYLDFHRCEKVKGQGDQVCKYFKNVYSSMCPNSWVEKWDGQRDEGTFAGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA31</accession>
    <name>A0A084VA31_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000323</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01001565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523979">
        <property type="protein sequence ID" value="KFB34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000323-RA">
        <property type="protein sequence ID" value="ASIC000323-PA"/>
        <property type="gene ID" value="ASIC000323"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000323"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000323-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7656" checksum="7ADB3DDB33E4EE2E" modified="2014-10-29" version="1">MSGVATRTKRSIRFRLPHDARSGVAPFSFVHSNSNVFPARWDGKMFSVLRPTSFDRANPGIEVPHRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAH0</accession>
    <name>A0A084VAH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAH0"/>
    <dbReference type="STRING" id="74873.A0A084VAH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000722-RA">
        <property type="protein sequence ID" value="ASIC000722-PA"/>
        <property type="gene ID" value="ASIC000722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000722"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="9951" checksum="F1334D326009EC90" modified="2014-10-29" version="1">MDPAVAWYQEEQEGPSMAVWLRIWETNSELYSLNANYGPGSNGGGGGPEGPKGPRGSAGGGASEQNNNNNNNSNSNLQQTSPTGVEGNGKNDRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAK2</accession>
    <name>A0A084VAK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00000811</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAK2"/>
    <dbReference type="STRING" id="74873.A0A084VAK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000811-RA">
        <property type="protein sequence ID" value="ASIC000811-PA"/>
        <property type="gene ID" value="ASIC000811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000811"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008223"/>
    <dbReference type="OMA" id="NGDMLMK"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17948">
        <property type="entry name" value="DEADc_DDX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="137"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="341"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="526" mass="58885" checksum="6C7237FF2D901075" modified="2014-10-29" version="1">MAFPLGGPFVSKAMKKFVKVSFSFGRYFSTHPSPLASAIAQPIPVITCKRQPFNLYQHDLPADAGRVKLGDLPLASDGWRHRKSNGDYFIIHPMQQAYEAYALSKGTFNELGIRDTLVENLKKQHVLFPTQYQVEGIQTVLDGSHSLLAAETGCGKTYTYLLPILEQILRRKLNAKQREFNTPLVLIITPGRELAQQIGNVAKSLTEGLGITTRVVLGGRTKQQMLNPSFEDIDILVASFGAISKLVTSGIYRMEEIRYVVLDEADTLLDDSFNSKLLHLMKRFPFHKNHLQDLAESIRGTQLILAAATMPSNMEELLSKLINVATIEQVISPNLHRLMCHVTQRFMRVRKSDRPQILLDLVHNDRKRNVSTIIFSNKTPACDFVSLHLNGHGYPCVNLNGDMILKLRLGQFEKFQQAEVNILSTTDVASRGLNTIRAAHVINFDFPLYTADYIHRVGRIGRIGSRSDCLVTNLVSSQAEIGAVQRLEHAARTTSPLRNVDANVKGIIRRNILKRIEAQEGGPMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBH9</accession>
    <name>A0A084VBH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001578</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524386">
        <property type="protein sequence ID" value="KFB35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001578-RA">
        <property type="protein sequence ID" value="ASIC001578-PA"/>
        <property type="gene ID" value="ASIC001578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001578"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="10122" checksum="204288A2D07E15F3" modified="2014-10-29" version="1">MRENFFEAQRSPAPHQQKFVASLERTICALPGFGFELLSERTLKLGGSQSQYCPTIRSMNVFQTKTIRFEPSSIIWKLTCWVERFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC78</accession>
    <name>A0A084VC78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP001533-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00002419</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524586">
        <property type="protein sequence ID" value="KFB35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VC78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002419-RA">
        <property type="protein sequence ID" value="ASIC002419-PA"/>
        <property type="gene ID" value="ASIC002419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002419"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011453"/>
    <dbReference type="OrthoDB" id="2019917at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="7">
        <location>
            <begin position="564"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002419-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137822" checksum="79FEB3DAEDF43B6E" modified="2014-10-29" version="1">MSCEVKLLSNIDDLSEVQEQFGLRSEENWLNAVCYALSPAGDILAFGHGSILVVLASRWDRQRQLNVYKTVWRGAIDDPNRIITSILCTPIVGQGQSSQSMVDFSYIIVGLDSGQLLFYGENGTLIHSQIFQQEPIQALKAQSGKHINEELYVMYPSCSVILQGSQVFPLLRSLRQQINRYGVGSPKVNEAQETIACRKWSYEKGMTIVDAVVVGPQKSCTFDHLLTASLEGGFFAKYRHSAPQNSLIIAAGSKPYVGFHYAKEGFTQPVLADVARAVASKIKSAFPSWLGGGGTSAQQQATVEPQLPPSEPLICRFGLCDLQLADNLGRVILVDCQRGLALRIWKGYVTPSAGRRGTGKATEGIXXXXXXXTDVRSVSMQAGKSTLRVMCENYQKLVMFYQYLHGDIPSIDVMEVRQLKDAESMDTTGDEQRDEKVDEKQVNVKLSEQELTVIEQLIELIRMNEAEGLHAGQNGAVPGTGPSTARGVKFDESAASGVRNASFMEYLSSFNVTNDDLILLREESGPNAYASLGKIIFERLYRFDQHRLVGFVASAEACGMMPEDLLRLFLAYWLRLPFTYRDTAALVDDLNRFSAVLHQICLLAREKIHFENNALCLWWQSVREYLLESPCALRGLLAALMCRNEALRHENRRRSDDAETDVAGEQFEQVSQEACQWMLLIYKLEDVAILGTILAECVRCRNPRWPTLKYHKPVVSLKEILTGGKGIVSELAAKWVASTGIEPAMLVIEVPQEATETEPKPAGDGGGGGDPKSNTSPSKESTERSDRKERNRRLALIKANLLQTSEYGPAKDDGGEQEELDPVLYNLNILRLHFPFSLDSGQLLAQLAWEYIGAWSRNMPNMACLQAGLACLTAIPRLQYSIKHGLCCMIWNAHLKIPLEATKKLVNKVGRLPKEKLCLQDIGISDALVPQFLECCLEFFDQFAGSIDHDKLELRFEDLLQEGPVPLTVLATQQNSANMALLRLHQELTTTLLILTSFSVRYTNKPIQQLFDGMANQAFFSEINRQLSATNALPKADQLLRKARVEFLCRTVTATMDLIREDMETVYYADHNSWMDTIERLAGAWELEFGDIRKHQIIELYAHGWDTYAHELLENVVADHTFANLLLTIAGRRLALYTKANPSSWAQIASVGPLLTDYLDTLVSNSSYGPPLRFVETDEATLQTAAGGDLFIEKITKLTEKAFNSLSSLAVNTKGTSKELRVAGMIFDACATIKDHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDS4</accession>
    <name>A0A084VDS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">DNA-directed RNA polymerase II largest subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00003171</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524715">
        <property type="protein sequence ID" value="KFB36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDS4"/>
    <dbReference type="STRING" id="74873.A0A084VDS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003171-RA">
        <property type="protein sequence ID" value="ASIC003171-PA"/>
        <property type="gene ID" value="ASIC003171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003171"/>
    <dbReference type="OMA" id="XAESPRY"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="234"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003171-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="341" mass="35194" checksum="797C401A608B8A8F" modified="2014-10-29" version="1">MSPSSWSPIRGSPSSPGPSMSPYPPSSPSMSPSYSPSSPNYAPNSPGGASPSYSPTSPCYSPPSPQYSPGSSNYSPSSPNIHSATQNYSPTSPSYSPMSPMHPTSASAYGSPAYSPTSPSYSPTSPSYSPSSPVFSPTSPSYSPSSPSYSPTSPSYSPTSPSYSPTSPNFTPVTPSYSPSSPNYSPTSPHYSPASPSYSPSSPKYSPTSPSYSPTSPSYIGSPHYTPASPQYAQTSPNYSPTSPSYSPSSPQHSPGSSSNHYSLGSSSYSQTPAPYSPNMSSYSPSSPKYSPTSPVYTSSSPTYSPSSPAYSPTPQGYSPSSPASPTYSPTSPSYDDSNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEF2</accession>
    <name>A0A084VEF2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003849-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003554</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC003554-RA">
        <property type="protein sequence ID" value="ASIC003554-PA"/>
        <property type="gene ID" value="ASIC003554"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003554"/>
    <dbReference type="OMA" id="HYISSYN"/>
    <dbReference type="OrthoDB" id="8054656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="795"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1404"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1205"/>
            <end position="1217"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003554-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1434" mass="154306" checksum="F67658B8F9CDBB08" modified="2014-10-29" version="1">MDHPFPSRKSLPEKADLKSRSDSTSVPPLDSIYTTPTGFHSQHHHHHHPHHGAHHPHQNGTPGSPEAMKQTPNSETDCTVKESLTDGGSTAGSTGSPAPGEGRPAAADTVEGIEGAPSQSQGSRQGEAASASGAGGAGMEENPGLRLPTKVSDYGLERFNRLLDRLDRGNFLIKTSFKKSYSLILMSRSSAPAGDIPGAEGGEPTKGNNSSSSASSSSNSSTAYTGTSSGTSGGWRRPRRPGKDLGSTVGGSLRGWYPKARGALIKANSSSGLYQLTLGSERSRDGETVGATTEKVTSAGGKSGTIPTGSDTPASTNDSSSATAERLSPARDSHPAPHQEVAPEAPTSIERNYNGVGLTQSGTPAGERDCQSHSTNESEEFCRSEVYDNDSGSGGRTEPGNRPSDGSRRQRSPRKAIDHKPTPTPHGNYENIRPSAEEAGQRGPSHWCDSRTLGHSYRKSGGRRKSNTPALTWGAFQDDDNDDPDDGWSQCEESERLSMSLPHATAEFQWQSSSGAVPIQFFQRQDYIQPTANDGSDFPADHLGSEETGGKRQGKKRWLGGNKKSQFTSNAIGRGEFTGQEMGNKIPHDRSFQLPALFGPASGGKGRPRPEKVPQLKNINLHFPNKTSLQQLHQKQQQQDFDGFHPQHELTTSGGVPAGAVLVPPPAGSASHRTPHGVGKSERKYFNKAKSHFLKLGQKCRLVLAAGGGAGTGSGRARSGSRGYHQQHHHHQHISSYNLDDLIKATHKYEENESANLSQKIVYKSYKSELDLTKNLAYLDSFLNEHFDQEQVVSERRQLGGRNQRHKRAKSCTKSLHESSAKVSAMSESTVETATSNLIQLEDVWSGGTRGQWAANNTSSSSSEYLRNNLSTARALAKPEVRVKSKLKDFLALTDGTPLEGQLQDDDEDEEDDDDEDDEEEEEQDDDRMLLYDATGFTNALGNTASHGPSSARTHGGVLVEQYGKNNATSSSLSSSDYASVYSATSSGNGASKSGPMKLLATPEEAMSGEHLPTGGRLQQSARIKQQLLHTNNATNPFVAPTGGENLAGKSIETPTTGYAQHHRIYNNFLEPMADGTGAFAVPVSPKASGASRRMEKNHRLRSNTHSIAYASEGGRHLLPAATSPRGTRAIDRYDYRVQSQTQHPTNTGSRPMAAVSMETDLTYQEDYLEHYQHAAARALRSSSSSVGGDRALQYLHRARHRTAQPMSPTLRHSNPTADPRNNGPANENSTVDSDDPDHEPGFVECAVDDGEEGSCIRMDDTPFDADVSDEMLLLVSAPIDIRRNNAPGADHPFLGSVREKSLHNAFAELQQDIPAVTGRKKTNEPLTGSDSGIENDGKHLLSYQPQGYDLSSNQLFNDEYRPLGTVGDPVAASRHRSTTLSAAGLGAHRSRKTSPGGKGPSAMGNSFLNYGPHRVIVSQSHKERGEVVLEYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF40</accession>
    <name>A0A084VF40_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007723-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003779-RA">
        <property type="protein sequence ID" value="ASIC003779-PA"/>
        <property type="gene ID" value="ASIC003779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003779"/>
    <dbReference type="OrthoDB" id="8057566at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6777" checksum="74D07D652ECDAE8F" modified="2014-10-29" version="1">MAAGTPNSIEVQIDNFLEQFKRSASKAMEGDWSSSSTVTTPQSATSSGPKIRNIFADQAQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFR4</accession>
    <name>A0A084VFR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000739-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00003970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFR4"/>
    <dbReference type="STRING" id="74873.A0A084VFR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003970-RA">
        <property type="protein sequence ID" value="ASIC003970-PA"/>
        <property type="gene ID" value="ASIC003970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003970"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020452"/>
    <dbReference type="OMA" id="RHYYFYL"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17954" checksum="98CD4233A292719E" modified="2014-10-29" version="1">MFMPKAHRVAIYEYLFKEGVLVAQKDFYAPKHPELETIPNLHVIKTMQSLKSKNFVKEQFAWRHYYWYLTNEGIEYLRAYLHLPSEIVPSTLKRAARSEPQRARTQAGPRPDGPKSGEDRQAYRRMQQAGPGDKKGDVGAGAGDLEFRGGFGRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFR9</accession>
    <name>A0A084VFR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP001083-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00003976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFR9"/>
    <dbReference type="STRING" id="74873.A0A084VFR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003976-RA">
        <property type="protein sequence ID" value="ASIC003976-PA"/>
        <property type="gene ID" value="ASIC003976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003976"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006128"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000765">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="17681" checksum="68BEBB2E9A88C19D" modified="2014-10-29" version="1">MTSVWALKVEYAFFKVWGIEPYAEGGSMHPATRLKALQQVQQSSASASSGGTSSTGRKGQSSKAKAANAASNADAGATAAPAGPPKPVFECTVCGKGLARKDKLTIHMRIHTGEKPYVCEVCDRAFARRDKLVIHMNKFKHITPTNIAPLGKRQNRTLTIGLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG00</accession>
    <name>A0A084VG00_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP002071-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00004062</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG00"/>
    <dbReference type="STRING" id="74873.A0A084VG00"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004062-RA">
        <property type="protein sequence ID" value="ASIC004062-PA"/>
        <property type="gene ID" value="ASIC004062"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004062"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005373"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="135"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="509"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB36894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004062-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="742" mass="83546" checksum="C2D6652237B0A269" modified="2014-10-29" version="1">MPTIISKFAKKSFDTLEGLGYSREFVSKGLITGAVALYCLRLTYPVVKERISAAKAGTPPQSSTPGRNENNNNLTKQTPEDPEAKKEQIIIEKRNRRKPPQPGLNLDFLLQLRQLIRIMVPRFLCEESGLLAVHTLCLVSRTFLSIYVASMEGAIVKFIVRKDVRNFVLMLLKWFGIAIPATFINSMIRYLENKLALAFRTRLVKHAYDMYFKNETYYKVSNLDGRIENADHRLTDDISTFSSSVAHLYSSLTKPCFDLLLIGIAMARSSRRMKANIVMGPALATVVIGTTAHILRIVSPKFGQLVAEEANRTGYLRHVHSKIITNAEEIAFYGGHKVEHAQLQEAYSRLVGQMNNIFTQKLWFIMLEQFFMKYVWSGTGMVMVSLPILTVGAGGQPVSPEQSNLIKSDETGVSERTQYFTTARNLLLSGADAIERLMSSYKEIVALAGYTSRVAGMFEVFEEVNRGIYRKTTLYTEERNLDGILEFRDGQPVAKGRIVFAVDPKDSSISLENVPVVTPNCDIVVPSISLTIEPGMHLLITGPNGCGKSSLFRILSGLWPIYAGTLRIPRSSDGKASMFYIPQRPYMSCGTLLDQVIYPDTRKDMEAKQITEGQLRDIMRMVSLEHIVDRDSFDEIRDWKDTLSGGEKQRMAIARLFYHRPKYALLDECTSAVSIDVESCIYETAKSMDITLLTITHRPTLWKFHTHILQFDGQGGWVFEKLEEGAQQKVPMLKSNQPTSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGE0</accession>
    <name>A0A084VGE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004216</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524818">
        <property type="protein sequence ID" value="KFB37034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004216-RA">
        <property type="protein sequence ID" value="ASIC004216-PA"/>
        <property type="gene ID" value="ASIC004216"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004216"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004216-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10251" checksum="7D2660AD6BE36832" modified="2014-10-29" version="1">MKDSKQKQKQQGQDVFQIQFPKERPRTAPAAAETCSSSGLGKLTGQNGTTKKHTTVYDSTYARRTLPTPLRLALAFALSTTERLAHALRLGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGQ0</accession>
    <name>A0A084VGQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000997-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LAMTOR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524836">
        <property type="protein sequence ID" value="KFB37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGQ0"/>
    <dbReference type="STRING" id="74873.A0A084VGQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004350-RA">
        <property type="protein sequence ID" value="ASIC004350-PA"/>
        <property type="gene ID" value="ASIC004350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004350"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014100"/>
    <dbReference type="OMA" id="YQVIQMN"/>
    <dbReference type="OrthoDB" id="343907at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000003">
        <property type="entry name" value="ragulator complex protein LAMTOR3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015019">
        <property type="entry name" value="LAMTOR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13378">
        <property type="entry name" value="REGULATOR COMPLEX PROTEIN LAMTOR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08923">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01278">
        <property type="entry name" value="MAPKK1_Int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13811" checksum="9824C122381D690B" modified="2014-10-29" version="1">MTDDVKRFFHTILKRVTGLNCIIITDRDGVPLMKVGDDKSVGMIMKPSFHTTFTMATEQSNKLGLGKNRNIISIYTGYQVVQMNKLPLLVTFIGNESCNIGHILALDQQIEVVLDEVKIAVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHQ1</accession>
    <name>A0A084VHQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dyak\GE23270-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004717</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004717-RA">
        <property type="protein sequence ID" value="ASIC004717-PA"/>
        <property type="gene ID" value="ASIC004717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004717"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020132"/>
    <dbReference type="OMA" id="HAGRHSW"/>
    <dbReference type="OrthoDB" id="8067110at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="9278" checksum="E1B3D4E1B82FF90D" modified="2014-10-29" version="1">MSHTTVSASVIQAVGGGPATTGTPSTPGGPPSSAGASGGVGSGANGSSTNHHWSHAGRHSWDPGRIGVEHLAGALSPLCITDANHEIVRPKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI74</accession>
    <name>A0A084VI74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004928</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013324">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524853">
        <property type="protein sequence ID" value="KFB37668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI74"/>
    <dbReference type="STRING" id="74873.A0A084VI74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004928-RA">
        <property type="protein sequence ID" value="ASIC004928-PA"/>
        <property type="gene ID" value="ASIC004928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004928"/>
    <dbReference type="OMA" id="EKHHSIT"/>
    <dbReference type="OrthoDB" id="7744763at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF12">
        <property type="entry name" value="HL02234P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="27604" checksum="B6BB4013EA7FC938" modified="2014-10-29" version="1">MRKCVSWRDRDNKTQEFSSEFLSVPITDNGHYKCIAAQTEKHHSITIVRSNSKQTVDARTLNFGKANMKAFIVFTVALAIACAADVDESKKEKRGLWEESYDNYGYDNYGLGYEKEVKHVITKKVPVPYPVEVEKHVAVPVKVPYPVKVEKEVPYVVEKKVPVYVEKKVPVHVDRPYPVEVKVPVHVPVYKKEYVEVPKPYAVHVEKPYPVYVKQPVYVEKQVPVTVQIKEHHKKPFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIQ6</accession>
    <name>A0A084VIQ6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005105</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01013379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIQ6"/>
    <dbReference type="STRING" id="74873.A0A084VIQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005105-RA">
        <property type="protein sequence ID" value="ASIC005105-PA"/>
        <property type="gene ID" value="ASIC005105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005105"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001118"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021772"/>
    <dbReference type="OMA" id="PHESIFE"/>
    <dbReference type="OrthoDB" id="7791411at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="855"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005105-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1223" mass="138237" checksum="180740C320ECC651" modified="2014-10-29" version="1">MDAHEGSVQTKSGFAKEQSILQHESGKPDAETAPKPISGQRRLFEQIKKRGLLKAQQQADSQTEANRTTGGECIDERHADDQVEAETGSERDDKEVVRSSQPHLWQRRLQKKMKQLELLKQQQSDHQKGGDDGKEELRMIRCGVASELGVLVHGRFSPDPIDTIEKAKFFPSVVAALKKYFVRRVFRLQAIAWPHIVEGNSLVCVSSPRTGKTYAILPAICSRVMGLLMNGCALLVTTAPAYKAIYDASPSVFMRARVRVIAIDNFDRMHVACSSELEACRKHWEDPTLQMVVTSTSWHPQLATFLGRNKNTIICIGSYMEAALYAKVNFQVEMKRDSDEKVRALVQFIQEHDYRSQRTIVLTRNAVNIERMVKALQQHAIDFIVCSDSDSIAQNDGLQDWDDRTPGNIPLLICLDDLLGEIQVSKAQHIVHYSMPSSWKMFTKRFVASFDFYEPPKNKPEEPTNRPSSLVLLDEIDNDLLVNLADLLQRYSVACPDELTMLAQTIRNKNATEGRGPALCPQLLALGACRRYRMCYDRHVPVEHDLQHQLPTRGIVLLRVIKTISPVHFRCWISDSDPNGDFSRFTDETNILQCNPAFGDSADLSIDVRIAGVVPSNNDEDWNKYSMEHAQQLIKDYSDKDHCYIYGNVLLTLRDMIWIDELFLVEDTKSEERSLVTTEFTASLISKKYGKRNMKSFELVKQFIQQCKAEVKEASEPGSPIAVDTDIPSEERIGGAVSLPPDSPPEPETVEPVLSEPIVSSLPPEPLAENANKRSIPIQLGDFSVKKTEEEMARFRSDLMNRDSVSLAGSFEELVPSPEHEEYSYERLEIGETYEVGLTAYNAPDNFYIYLVERDVEVGAYCLALEGKTFVRGEINEIRNGAIFVFLLDYGDMIICPHESIFEIPTHLLRLFPFAAIEATFAYIVPTEGEHWTVEKSLEIYDIVLEKHNSTLINMDAYVCGTLAPRRDYGPAHQQYKVILTTCNSSEMFQIIGELLAYDLVLFDHEAFQQDCAFDSDDEGEYVERFAKKKSRASVKELRPEKSHTLSELPKPSTAEKKSPPAPSVVVNDVYLQPRQRSFRYPSTQWDQDDHGVTLYVSAPDVSNHEFVVSTDFVQLRFVCSNELYMLQLHLFGAIDAAQAKYAIRGLTIVVRLPKLGNANLPWPALVNHSNKLIWLKKALARNSDSESESSSEPDDWTKIPLVEPDEDTSSLDSQEDGVELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ65</accession>
    <name>A0A084VJ65_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005273</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013467">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524859">
        <property type="protein sequence ID" value="KFB38009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005273-RA">
        <property type="protein sequence ID" value="ASIC005273-PA"/>
        <property type="gene ID" value="ASIC005273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005273"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7989" checksum="519FC1A41C9DD270" modified="2014-10-29" version="1">MSDAFVPLQRLLLRGPFITVRCNAEANLFAELHKLCMLDFAAAAALAECGSPLEKQKKFHTGTDDRGRQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ83</accession>
    <name>A0A084VJ83_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00005294</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524860">
        <property type="protein sequence ID" value="KFB38027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ83"/>
    <dbReference type="STRING" id="74873.A0A084VJ83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005294-RA">
        <property type="protein sequence ID" value="ASIC005294-PA"/>
        <property type="gene ID" value="ASIC005294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005294"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002715"/>
    <dbReference type="OMA" id="NTAKYEC"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF99">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005294-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="402" mass="45750" checksum="1AF66155F769DF60" modified="2014-10-29" version="1">MIQQGEDVCQPFCFRLSPPPPAPAQIPGPVAKPIQRRTRSFQRTSASCDVRSKLLQLALLILACCGGLTDGSWWRIADLSLDAAHFHRDNRSFELCGDGTFFTAQQRDTCYDNPELLKVIVHAANTAKYECQTYFQNNRWNCSAKRGNNIYYGNFDDKGNRETAYLSAINSAALAWTITRFCTKGELSSCHCDHIQRKKHSKWTWGGCSEDINYGIRQARLFTDPTENRTSSFGLMNLHNNEAARRILRSRMEKVCKCHGMSGSCTTRVCWRRLPPMKLIADTLGSMFDAAAQVKPVENKGIIKKLMRKDLEYKKVNKSDLVYIAESPNYCEENESLGIFSTRGRFCNRTSYGIEGCRLLCCGRGYQTRIRNVEEKCNCKFVWCCAVKCDTCSMRKDEHICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKP7</accession>
    <name>A0A084VKP7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005818</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKP7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005818-RA">
        <property type="protein sequence ID" value="ASIC005818-PA"/>
        <property type="gene ID" value="ASIC005818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005818"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022076"/>
    <dbReference type="OMA" id="MANINFR"/>
    <dbReference type="OrthoDB" id="7737235at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="55675" checksum="AD777402566B22CD" modified="2014-10-29" version="1">MRMKLIIATDIQNRSVMEKLIGAILKTEHHEAVFMIHNHERNESRALTYHPYRKEYTTHRIDEYHTFYPDYHRNFHNKPVITCSMPAAPYIIAQPGSKMVSGIDFAMLQVIGKMANINFRLKVYLVSKLQTAKILEIFNKTDVSIWFNRMALKYFIKQSVTTPDMSEYVIIAPRGQRLTIPETFLRPLTKAAWILVIAMVVVSFLVMWNFNRYFRNDLILLPVCGIERYNLNQTHFAEKLIVLGLMVFYFLLQSGYESIIISLISDVPYHRDILTFEQLRESKIKVTVIDQHDINFFLPLLEHYHLPVENGTTPEKENLQIDKATLHDDRSGKMLINNPDFYDRTNERKRLNLLQDTISAHPTSYVFRHRTRVQETFERHMHTIFEAGLLNYWAHFFQKMSDSRLKATPPSEDDEIVKFGDLAPFWAVIGVGWSVSIIVFLLERFTTLQLEVKLKAPRNYRNSFQTDAGSIIAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKV3</accession>
    <name>A0A084VKV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP010550-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005973</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKV3"/>
    <dbReference type="STRING" id="74873.A0A084VKV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005973-RA">
        <property type="protein sequence ID" value="ASIC005973-PA"/>
        <property type="gene ID" value="ASIC005973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005973"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022472"/>
    <dbReference type="OMA" id="CHYWPKG"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783624" evidence="5">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="88"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005973-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="288" mass="32972" checksum="F573698F6EC8623C" modified="2014-10-29" version="1">MSSEGISSPSTPRAGTTLRVVTVALFRSLLLVFLTIDSQPHFNTLAFDYCAASKNLCQPATARHVVCNGRRFSPACQSHPKLIKMKPEYRKLILDFHNRLRNNLACGYFRRYAEASSMEQLHWDNTLARMAEYNARTCNFAHDECRNTRKYRQVGQNLAINWFHGVNVSVPAAIDKFQRHWFLENGRGRQKLLDRYGEQSMRAGIGHFTQMVHADTRRIGCAMVRFRSVKQGLAVTQYYLVCNYSEGNLYERPVYRKGRRCSKCKYGCANNGTQYRCLCATGTVQPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL00</accession>
    <name>A0A084VL00_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006037</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014367">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524965">
        <property type="protein sequence ID" value="KFB38644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL00"/>
    <dbReference type="STRING" id="74873.A0A084VL00"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006037-RA">
        <property type="protein sequence ID" value="ASIC006037-PA"/>
        <property type="gene ID" value="ASIC006037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003833"/>
    <dbReference type="OMA" id="NRFAHSQ"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF35">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783609" description="Nucleotide exchange factor SIL1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="443" mass="49565" checksum="EBE8F6062934613C" modified="2014-10-29" version="1">MRLKFVIVCLNVAFIVGGNGTGSNETAFVATNEWQEIKEGQSIPQGLHVRINLSTGKKEAKLLDPDDGTDSSLSMVPGEELKDHGVDRAAPDTVAGLKLDALRDALRDIPADVYEEDENRDDTIRGKFKSYEQIKQELKDANVELKSDSEIMSALFDRFSETLSKTTAEQRPELDALFEDLQYLAHQIDNALNFIDRGGVEKILWPSLNSTDDAPTRVQALKLLGVIVQNNPKAKVALVERNAGTNLLTALGRASTTEEISAALYAFGSLVRKFPFAQRQLLTPHGYSLLYGVWTKKVELKVKVKVLQLLADVLEDYVAATEGGAAGPDQTTVEQYRSTKLIEGLEKTEFCKYAGEFFHQHRTVLVPEENLSDETVQALRSCGKLCHDAWSQCPLFRHTLLVLRNNLDHRLDEDSELVEYRRDIQKNIDDFIGELYGQPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL63</accession>
    <name>A0A084VL63_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL63"/>
    <dbReference type="STRING" id="74873.A0A084VL63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006108-RA">
        <property type="protein sequence ID" value="ASIC006108-PA"/>
        <property type="gene ID" value="ASIC006108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006108"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006340"/>
    <dbReference type="OMA" id="HRDNNTE"/>
    <dbReference type="OrthoDB" id="10067025at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006108-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="310" mass="34974" checksum="090EEAA64EEFA8F3" modified="2014-10-29" version="1">MSGQFPGGYQSPSGHRGNYNSPIIQQQLNQMNVPNQMGMMGFNQNSVMNNQQMQGGPGQGGQDMGMNQNMMQQTHQQQGTQGIQSNPQQVPNQHQQGQNQMVGQNQQHQGPQPSPQMVMQQSGGNVGPGNVMNNPQTQQNQPPPNQPGAGTAVQQQQKAEFNLLSLCRIGQETVQDIVSRFQEVFGILRGIQPPNGTNQGQLSSNDKKAKVQEQFRTIRLLFKRLRLLYDKCNDNCQQGMEYTHVESLIPLKGELERSEPVHTEEYKKALQENRELVAMVQLKNKQLREIIDKIRLTIWEINTMLSMRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL78</accession>
    <name>A0A084VL78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ABC protein, subfamily ABCB/MDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006167</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006167-RA">
        <property type="protein sequence ID" value="ASIC006167-PA"/>
        <property type="gene ID" value="ASIC006167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006167"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6435" checksum="307B8A49723A1AB5" modified="2014-10-29" version="1">MVHGIATRVSEQASSDKLTGRLRAMSYIWSTVGWADQFRPDVGRRLLRNTRSKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLY2</accession>
    <name>A0A084VLY2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006505</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLY2"/>
    <dbReference type="STRING" id="74873.A0A084VLY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006505-RA">
        <property type="protein sequence ID" value="ASIC006505-PA"/>
        <property type="gene ID" value="ASIC006505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006505"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002883"/>
    <dbReference type="OMA" id="FENSHAR"/>
    <dbReference type="OrthoDB" id="8179031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783653" description="Hemolymph juvenile hormone binding protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006505-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28116" checksum="AD3EC654EAB6C547" modified="2014-10-29" version="1">MLYSRVTFTALVLIVYLGGSFGAFPPSIKICSRNDPELSRCFVESINDLKPRLATGKISDDFQIPPMEPLALSNVNMDRGAEFKATFSELLVSGASQFRIDNLKANLETLVFDFNLFLPKLSFKGKYNLNIKLLLLNIAGTGDLKGVFENSHARVKVLWEKYIKNGKEYLRIKKLLVRIQIENGQFDMKDLFRKDPVLSQVGNQFINENSRLFLDELTPGLERSLAETFKAMANEIMQRATFDESFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM55</accession>
    <name>A0A084VM55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ATP-binding cassette subfamily C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006762</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006762-RA">
        <property type="protein sequence ID" value="ASIC006762-PA"/>
        <property type="gene ID" value="ASIC006762"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006762"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006762-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="18854" checksum="91E2907EF7E11D43" modified="2014-10-29" version="1">MPTFPSARTTRSPPSTSFCGGRETRESSTPGRIWIHLWWSSFFSVSQSAGQEELSVRQSPDAKPWQTNVPRKNPNPARKKQCIECETERVNHCSGFLRQFRMNPPSGRGSGEGVKAHNILAYLQRIQFVRLNVRPTCRVQPLVHVIRLPVEAVSKRIYRPDARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMF5</accession>
    <name>A0A084VMF5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Triphosphoribosyl-dephospho-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006481</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMF5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006481-RA">
        <property type="protein sequence ID" value="ASIC006481-PA"/>
        <property type="gene ID" value="ASIC006481"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006481"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006481-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="9055" checksum="D19FD47E8799FCC4" modified="2014-10-29" version="1">MNHHRRTLARRKFYHKYPINAPAVRPFSRHGIEWRRVVHHNVPLAGLALIALCEDKTLYGRTTDNADDDRRQRLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN90</accession>
    <name>A0A084VN90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006923</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
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                <person name="Hong S."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
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                <person name="Yu J."/>
                <person name="Hong S."/>
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                <person name="Zou P."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
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                <person name="Shen B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Lamellipodium</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS023542"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1601" mass="175165" checksum="61B33E75443D9A84" modified="2014-10-29" version="1">MDTSAITVQAQYSFKGSNNDELCFKKGDIITLTQREEGGWWEGTLGDKTGWFPSNYVKEYAGPLPLSETIRPPEEIQAFRSVVFRDLLESEKAHVAELRGLVENFMEPLETSQILTGNEYAQLLCNFLEVVEMHEEFLQTLEECNDRVGKVFLSKAPTMKKIHQIYCAAHPRAIVIVDKFREDLNVFMEKQGAAKPGLLVLTTGLSKPFRRLDKYAAILQELERHMESGHPDRGDTQRSIAVYKDIASSCSATRRQKELELQILTGPVRGWQGAELSTLGDIIHMGSVAVGPEHKDRYLVLFPQTLLILSVSQRMSAFKYEGKLPLTGITVNRLEDTDQIKHAFEISGTLIDRIVAVCQGPSEANRWVELLSPKAGSGSEQTSGGSSVDLKRNVSSSAVNIPQPPPHEKKQLALDSRGYSTRVSICAFGSSGPWVTKYGSDFEVTYPPASYPSTAPYAQLTAYLRRLFRAGELSRYVVQALLYPQVTQTYDRRQVVMRRKRHKATVRMQRRDQANAAAAGGEDVNGNTTVGQISSNVEAVASASFESSSSGSSGSCLSSSCSRDRSHLERQNAVDYVEDDDEAYETITFFAGKRKDSEEPDADSTVYESYSDPHSTEGGSFKYARCNSNRATIDSEDSEREEVGRDVEHEGHRSSEMIGSTAVPCLRINDRESITGSDGTWGAGKSSAHHISSIHTSTARLLLGDLKQQASEQSQMSSFEHRTGHAGRMACEDLLKLDDSMPVTHSLQQKTIVEERHSMPTYFVGNRFNNSSVTEIYIPSWKAEDRTAGANSGVGGGGDDVVGQTGSDDRNSVHSSSLDIPAIVPAPDPVTAELLYNFAKTTTTSPETSGSGGLDLALGGCLSREQSPFRKHSINSDKKLVLNPTHHRKGKNDSHEHHASGEPSVGPSARSPAARRCISYQYLQLQAATKPLRPEEKPLDSNNNPSTRVNQRNDHCQSEHSGIGFEFDAPSITSPDGHKCRFCSFYSRGHSPHSSDSGMAGSCTISTPDGPAKFSGDFLLCDYAAQRATQSVDVVDTRDIGDDSDRPHEHDVVCGDVVDGFPLPARNRERDRSGPHMQSPLRHATSSHNLGRFALVKDSEFDYTDSGQYDHHHNDPHHNDSSQSTCQRQIVTNEDIARRGDNIADTATVALKEHSPYFNTATEELNRGSRSRSEDRILSSFSSQDRDDAGNMELKQYFGRSRIVVNLYDRSSTRSVPKATGGGAGSDMITFKTGLYAHWWKKEKLPIFVVTSQEALKLPPATGRLVRPKSPQSPPAAFPSHPHQVPPISTVEPTSSSRECAATAGAAGDGLLWRPINTTYRRGAARGSGKSMSPPSMTGSSHPSRSGPSSLVQQMPQHKRSQSFNHHLSYNQVQQQQQQQQQQPQPQQQKQHQPNLNQLPSLNSLSLSRPEGKQASPNQKSFLEKANWNITNLRPAPPLRPAFLSSVAISGPGGGSNSAGTGGGRSATASITGSIGGAAASCVGGGSGNGTLNTNDSVQHGLSFSASSKVSPTYEEDALVLRVIEAYCAAYQSTSRNTMHSGFEYDEMTPTLRQLFISVRQLQQDMAHVKLQIAEERSQRGHLQQVLMGHLETYGAANTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPF2</accession>
    <name>A0A084VPF2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007218</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01015001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPF2"/>
    <dbReference type="STRING" id="74873.A0A084VPF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007218-RA">
        <property type="protein sequence ID" value="ASIC007218-PA"/>
        <property type="gene ID" value="ASIC007218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007218"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019295"/>
    <dbReference type="OMA" id="GHLCKDA"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="588"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="922" mass="103944" checksum="25D889C0E569C54E" modified="2014-10-29" version="1">MWAPESEISSIAFTNMRHSVSASSGISTLSSCGDPERLPELPPGDEQRLQRAALNLQQKLILREWLKEHRLQHHYSRLVAIEVTTLEDVYWLEDSRASQILGKDWPAWSSARQKLPTSKPNLEALKADLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVHWDWTDPARVGGTMCFTVRFHQRNGQAYPICDTDQFFVEVTEGTRKIVTISELGSPTDPNNANIAKVKFTVRTAGQYKISVLIGSSHIAGSPFLKTFIPGPMDARRSRLIRPASTVVCCAGAPTSLHIEPRDEHGNACQFDADCDPIKGYSIDIFDLHGHHSDKFASAITFAYDKVNTRISLTALFPEPVCLRAVVSYESNAIPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLFSIYGQQRWTKPRKVLCYVGPKQVTIKEMILKIIPKRIATFRLCPSTKFHFLPPSTIQMNNSHGAIFIIDDGCQPKIELASKERNVIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHSNYYHEKLSLKVQRDKILESSMKATKNFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSSLFDPRGGLFCTFHDKRQALVHPNPNRPPHLKLKHFEFAGKVVGKCLYESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDTSENLELYFVEEMYDQSGQLQKTVELIPNGAKVRVTNATKNQYLDALAQQRLCNNVREEIDSFLKGLNGIIPDNLLSIFDENELELLLCGTGEYSIADFRANHIVNGGSAEFRRVLGWFWAAVGNFSQTEMARLLQFTTGCSQLPPGGFQELNPRFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKALMFAISEGTEGFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPK9</accession>
    <name>A0A084VPK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007281</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015011">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007281-RA">
        <property type="protein sequence ID" value="ASIC007281-PA"/>
        <property type="gene ID" value="ASIC007281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007281"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5802" checksum="72A99D4D7CB483EA" modified="2014-10-29" version="1">MGLPLPLCKSGKRKKQHTSAFCMQHTSIANFDRKHGSEPYAKGKKRIDASNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPV7</accession>
    <name>A0A084VPV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007390</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB40001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPV7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007390-RA">
        <property type="protein sequence ID" value="ASIC007390-PA"/>
        <property type="gene ID" value="ASIC007390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8227" checksum="4491EB775A1C77A5" modified="2014-10-29" version="1">MVRDCAAIEQISGQCGDAPKFLTTRHPADMMAFPGGPPFDPHRSRYRPMDIDGNREDVEEKAENYGVFDPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQN6</accession>
    <name>A0A084VQN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007764</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007764-RA">
        <property type="protein sequence ID" value="ASIC007764-PA"/>
        <property type="gene ID" value="ASIC007764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007764"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12829" checksum="70EC0B3696871188" modified="2014-10-29" version="1">MTSCKWTPTAAHRVGSRRMSLGCGEEITHVPYHNWSIRASNAGLVDISRLNHPFPQGDGRSEATRTTQRDRVTESDQSDRHHKHTAQTLSPEEAIFCHSPGGSGARWDSFPSYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR67</accession>
    <name>A0A084VR67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007953</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015478">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525017">
        <property type="protein sequence ID" value="KFB40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007953-RA">
        <property type="protein sequence ID" value="ASIC007953-PA"/>
        <property type="gene ID" value="ASIC007953"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007953"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007953-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11736" checksum="7C083272055C13E0" modified="2014-10-29" version="1">MDFNPTPKSISNGKPNVVSTFVGGEASGRRANRDDRDSPPPSLLRGVMFVARFSQSQWTPAVRKYGKGRRRVERVYAGKKESESEANKTVRGDSQLSSIDHLPCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSK7</accession>
    <name>A0A084VSK7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">ZHAS_00008488</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell projection</location>
            <location evidence="20">Growth cone membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cytoplasmic vesicle</location>
            <location evidence="18">Secretory vesicle</location>
            <location evidence="18">Synaptic vesicle membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 23">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016065">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525055">
        <property type="protein sequence ID" value="KFB40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSK7"/>
    <dbReference type="STRING" id="74873.A0A084VSK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008488-RA">
        <property type="protein sequence ID" value="ASIC008488-PA"/>
        <property type="gene ID" value="ASIC008488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008488"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015673"/>
    <dbReference type="OMA" id="CIMLQMA"/>
    <dbReference type="OrthoDB" id="6232933at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018134">
        <property type="entry name" value="LAMP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00310">
        <property type="entry name" value="LAMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12 23 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 26" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 23 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783977" description="Lysosome-associated membrane glycoprotein 5" evidence="26">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="27">
        <location>
            <begin position="96"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="28">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KFB40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="316" mass="33724" checksum="7482C5E9FA07345A" modified="2014-10-29" version="1">MHAFRVPLAVLIVTVGLTLCNGQAETTTSIPTTSTTTLPTTSTTVTPPTTQPTTSTPSPTTTTTTTTTTTTSPTTTTTVAPSTTTVAPSPKPVPEPEMGTWSFTDSSNNQTCIIAQMAMQFNLSYFDATGKAVQTLYNLPKKVDRVSGQCGNSSDYIELQWDMGNSTNTSSLRLNFALNATEHEFVLSGVQLKLSVVGDAFPNARPSQQITLTNNQTLFKTPQEMSYHCNKAQLLNLTSDATGLGLPTVTVSKLQLEAFHAKHNSNFSIAKDCEAIDTPDIVPIAVGCALVTLIIIMLIAYLVGRNSAQTQGYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSZ6</accession>
    <name>A0A084VSZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008546</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008546-RA">
        <property type="protein sequence ID" value="ASIC008546-PA"/>
        <property type="gene ID" value="ASIC008546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008546"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007210"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009900"/>
    <dbReference type="OMA" id="EDEPDDC"/>
    <dbReference type="OrthoDB" id="6431454at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1898"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1704"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1775"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1909"/>
            <end position="1926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008546-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1975" mass="207807" checksum="B3B407B0603F8314" modified="2014-10-29" version="1">MLHPQEGKMMSPISALPPVCECGVRAVSGLGVLVTGFRESTSSLAALATTPAKKPNPTAPRDRTVWIAHSHAVEIDGSSKRVCARACGHDPSIPTKTAGKDAGHSRGLRARKGQDDWIGGPGVLIAGRYFNYCTSGVRVYVRTLRFDEIGHDLFTDSDSLSYASLSRSSSLIQFESLERQLQNESAVSQHPLSGSSPSLYSSESNSLLVPGSAGDTAGSGAARTADALGFYGVPTGARVPKGASTIGQGSNLLTTSNLIQKSIGQSTALNISDSELYSTSSSVSSTSSSSAGSCGSGASGVSGRGDSSSSNASSTGSSGYRYASDECNVARAVARDSASPRTTTESPEDTGDTEEELLSATVRGCGSARCSERRQHSACRGSTARNKNSIESLSEDSGYCDHLHVSMSGMRVRSKSLTNFGSAENITFICGNGGGGLFEPERQQLPPAALIPAVGRGSLSMTQPHHHQQQPLSMDYIPVEPRHVSFSENRLSTVCDVDEEEEEQEEEEEESVATGDGMTTIERNQANDATDDGHRTPARSERACWTNINNGTKIEHDLCKQQSASESQQRQRQQHHPPVTTRLTPPTPPDSSGEASLASCSGRSCSSTGSGSASSSSSSAESLSRAPMVTTLMASHSSEATKNSPTDVGGRRARTKLRRRRIPLSFSSPDLVLFGGAADRYRRRATERSSASSAYGGPSARAGLYDPISFTVSSVPECLNLYGGVRDSNGSDHHSLGSDSSSVCHSGSYGYGGSLPPSSVASKNFNLYDLQQHQQHHHSPVVTFGRTEGRCTKTVTFQTGSGGSIASPARPKQNIRASYANLTALNYSDDDEFEDGGHPVYGGGGGGRPRGHEYYLSRNTFRTSSGTKLGGGRVATTGKPPSTMNSRPVGNFLLGDERKKHEEVKKEHDESGDDGTRNDDADDGDEESRIFPLDRDEKNVFNSLLEEISAHFDRNLSIINDQAEAYEPIAAFLLEQKSLAGAKRLQTSLSGAASVATSSAVVSPTPQAPPRRTQIKTNPHHQQQNATANVVSPPKASGSVPSAPVVTSAFPVALAKAPLTGVTETSGQKRTFDQDPTNLVTCYAASLERCTFDPTESTSNLCPFVGAGQSQSSDLHTNRAVGAGRYSTVKREFVASTPNLNYYHGGDGGGGVGGGRGGPDGAGESDARRLRGSSALSVPDHHNSLRNVSSCRSAGILTTAATTTSSSRCGLSKGVSFCPIVSEIIWKSNSASDIEPDDNGSIISNQDFEIDIGDEDFDADDYEHAYLLTQTNTLINSNSVEQFEQLAAYAPVGSSSAAGMIVTRNASSSLEAVTGNNDHTATLRDDLREQRAVRARSDGALERDSSSSCTADYPNRVSQQLESAADGGTISRAMIGVENGRSEVNGLQSQQPQQHPRYLASNGTTVEAGSDFVSGGCAVMTSTVMSAARSNGGVDERSGYGGSEDRFLLQSAALAADASGGGDIEGHRKNGGNNSAGSAMASKNLIASESVEKGLPAGPVGVGSTLPASQYSNSNLIKNFKNGKAEKKGKTFLSRISSGFRFSFRNKSKKGAGLKETTFGVTGSGGNVGHGLPPMAGSANNGAAYNNNNNIKGKASGKASTMPSARGNDSASADFIYIPLKDPRRTDESAAYLRQMNTSGVTVDDSFTGAEDEPDDCEIAVTRPPGAAPYRSDSSTALNGEQGFQHHHHHQGHGSSVRAGGTGNQQRAGTNHVLSSKPPLPKQPPRVVGVCAKRSSTSPASGKHAHAQRASSTPPREIDDDEPDCSGSGGYYRRSPTQYAANSGSPYSGADTVSVEGTLPSAALLRSHYADYGDEYDDEDEDGQQQQQQQRFYYGHHRSTIMGSEQKIGLIETNLDTHETVISGKTRSLMELGAGAGGPHYRGHHPGQVVGHQLSVHDPSGAGQRRTIGGVGGQMNGQGGGPGGPGEQRTNGGPGRPHKSMEFLLDKENQRNVLVSLCLKRFLCFFVSHRLDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT26</accession>
    <name>A0A084VT26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008579</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008579-RA">
        <property type="protein sequence ID" value="ASIC008579-PA"/>
        <property type="gene ID" value="ASIC008579"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008579"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008579-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11073" checksum="294DF2A0F159E3F3" modified="2014-10-29" version="1">MFLSWSYTTTTWYTLSRTILSLDKSEQGKLVFSPPPAVPTGRFGAPSTCCEKFSLNASAQEFIQPCRTLISAPSVGSSASGMMITWEAYTGGCWMSFADVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT37</accession>
    <name>A0A084VT37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Metallo-beta-lactamase superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008695</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525060">
        <property type="protein sequence ID" value="KFB41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008695-RA">
        <property type="protein sequence ID" value="ASIC008695-PA"/>
        <property type="gene ID" value="ASIC008695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008695"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017436"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="17247" checksum="63E282D8A8CA1068" modified="2014-10-29" version="1">MKIDGKTEYHPRRLNRYTTALLNEIGYKGHGDGEDSNENTVRERSCVRVCDCLFGENHVEDVTFSQPVSYTTTTIIIERRHVRWCGGAQTLQLAVHRRCTGPFAYRKVPVVLGLGGGLDVDLNPSPTAGRCKNRLKACGLIRHLQSHIAPLMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTD6</accession>
    <name>A0A084VTD6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008896</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTD6"/>
    <dbReference type="STRING" id="74873.A0A084VTD6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008896-RA">
        <property type="protein sequence ID" value="ASIC008896-PA"/>
        <property type="gene ID" value="ASIC008896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008896"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008417"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013762"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="437"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008896-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="635" mass="71329" checksum="056253D38D8F4792" modified="2014-10-29" version="1">MFCAGGKNNVSACNGDSGGGMFFNIDGTWYLRGIVSFSPSRPEVDKALCDITKPTVFTDVSKYQDWLIRYINTTEWLKNLKPCNDSIIGRNTECNAVNRYDGDFFIVGEKESIVRVKVSDASASNEIEHINQNDLGGLDYDCAGGRVYWSEPATRTIFSAKYDGTDKKPFITEDLEEPRHVAVDWISRRLYWVDYGKEAIEVASLDNPAVRMVVNMNVNDPNEIAVDPLFGKLYRIHKNFLIESSNLDGTDEELLLDSSTMWISDLKLSMATEELCFVNQETFKIECINFFNKRIRSIASNLTSPHTLSVTDGMFYWTEGNGGTIESINHQNRRQPSIEYNKSKDVISLIAVTNVCPMVYSPCAINNGNCPDGTICLYKSREISGKACITIRSKINGQYKFSPRIGNMPSWYALIEGVPDFQYCEGSIITRNAVLSGRIYWTHNKTIYSAMYNGTDKKIFTTKGLKDPRSVAVDWISRRLYWVEHRHKAATIMVASLDNPELQAVVSTDADYTEIAVDPVLGILYRLLETGGIVKSNLDGSEPENIKTSKTHKLYNIRVSVATGEVCYINQTTSNIECMNPLTNQFRTVVSGKPKTWALTQGRYYWIEENSPCAINNGKCPENTICLPNPPCPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU35</accession>
    <name>A0A084VU35_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009071</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525098">
        <property type="protein sequence ID" value="KFB41479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU35"/>
    <dbReference type="STRING" id="74873.A0A084VU35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009071-RA">
        <property type="protein sequence ID" value="ASIC009071-PA"/>
        <property type="gene ID" value="ASIC009071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009071"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021196"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB41479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116429" checksum="5756456420F113FE" modified="2014-10-29" version="1">MGSSSKKHKRDSKKHKRRSRSRSRSRSPRYDRERELDHRSRSYSEDHESYNDGGTERRRHKKHKRDRSEHRQHHHHHQRHQQSSSGREHGRGERAHYDGGEVNAVDDDSDSSDCVEVPLEETSAPPPPPPSISARKSPEPAKAAPPSPPPPPQVQKRRRSPTPPPAPKASSSSSRKRSVSPIPANGAGDVLSVEETNKLRAKLGLRPLDVGPSKVQPEGSSSRRRHRSPSPPPPPKASSSSRKRSVSPIPENGAGDVLSVEATNKLRAKLGLRPLDVGPSTSEGSSKRRQRSPSPPPAPKASSSASSSTNRKRSVSPIPENGAGDVLSIEETNKLRAKLGLRPLDVSSSGPSSSSKEEGGRNESENYDKIKDDWGEFYHKPAKNLKETSQEEKIREKLAERREKRAIEEKLKRLKTLGEEEEVDDLKNWVAKSRDKERLKREAAERARQLDQMDEELVSGGVEEEEESSSAARQRQARRREQTYRDRDLQGLRVEHDVEAFTEGRQVILTLKDANVLDEEAGDTLVNVNMMDDERYKRSVENRKANPQHYGYDVYCQDEVDEFGQPKQREILGKYNEEIEGHRKRSFVIGTNAEQEAREKRRLLEIKTKLDRKKLDSLETTPLSLASDYLTETELASFKKPKKKVRKIRQKLRADDLLASLPEEETLADLGSRSKRGERSSGATTQERKSVRARAADILVTDDTPAMLEDLSTVKLEDTVEDDEDLQAVLQKARRLKQKEAIISKALPIDPERVKSEVKEEPDSGGEQQDHHGAMLLNSTAEFCRTLGDIPTYGTAGNREEDPNEMMDFERDSGSDHEGMDTDPDEGAGPSRRHDHRHGGTGGHHWQSRAKERREVAILDEEPDVALSVAGALKLAQSKGYLEREESNRPSNARFAHLQAQNYSIEDKNYGEENDKYSRRDRYAGPIMEFKEKETFKPNVKLDYIDDNGHLLTQKEAFRYLSHKFHGKGPGKNKIEKRLKKSEQEGLMKKMSSTDTPLGTLNMLQAKQKETQSPYIVLSGTKQTTSIVKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUL2</accession>
    <name>A0A084VUL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009287</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525136">
        <property type="protein sequence ID" value="KFB41656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009287-RA">
        <property type="protein sequence ID" value="ASIC009287-PA"/>
        <property type="gene ID" value="ASIC009287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009287"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="10023" checksum="21F3C856E74148ED" modified="2014-10-29" version="1">MAASFCFRSYRPSTVLEEDTHLKSSPYSICNPLMNKHARPLVGGKPAFGPAERRPPTIRHLLDHDVTQPPTGDSAVSTLDAWRRSCTFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV59</accession>
    <name>A0A084VV59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein KIAA0947 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009696-RA">
        <property type="protein sequence ID" value="ASIC009696-PA"/>
        <property type="gene ID" value="ASIC009696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009696"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8225" checksum="31363C6605364315" modified="2014-10-29" version="1">MVGAGFLLANRLSKRRFDPGSRPTTNPLLGATHREGGEGRACGYATSRRYRLQVAESANDVNRAPGTRPVCRHASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVR5</accession>
    <name>A0A084VVR5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009642</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVR5"/>
    <dbReference type="STRING" id="74873.A0A084VVR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009642-RA">
        <property type="protein sequence ID" value="ASIC009642-PA"/>
        <property type="gene ID" value="ASIC009642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009642"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023113"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009642-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="508" mass="56083" checksum="ADB53AAE8F2642BC" modified="2014-10-29" version="1">MDISTQSQVHGLNTSTMAARKKDAEAKENLWSSILSEVQTQSNTKLPSNKSVLVLGDNASGKTTLIAKLQGVEDPKKGSGLEYAYIDVRDEYRDDLTRLGVWILDGDPGHNNLLKYALNETNYAHTLVILTLSMTTPWSWVNQLQHWMKILDDRVAALKIDPEEKQQCQARLSTEWQNYCETIDDLDPGSPIKRTNRLSSVDDELDALPLPEGVLTTNLGLDVVVVVTKTDYMTTLEKDLDYRDEHFDFMQQWIRRFCLMYGASLFYTSVKEDKNCDLLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDNMKKISILYENMQSCKPDDYYNDIIAQPPSRKTVSNREIEIQTEDEQAFLARQQQLLQQGQTPTRGESPLRSQPGSNGKSAQRTPVAAGAQGSPKKVDGKLAPGTQSGEGVLANFFNSLLHKKSVSPGSAAAAAAAGGVAGSPLATSSPRSLNGVTVADPVSASDKISMRTDAALELDRLARSVKKDLDYSAAQSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW19</accession>
    <name>A0A084VW19_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013535-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW19"/>
    <dbReference type="STRING" id="74873.A0A084VW19"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009828-RA">
        <property type="protein sequence ID" value="ASIC009828-PA"/>
        <property type="gene ID" value="ASIC009828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009338"/>
    <dbReference type="OMA" id="VVQTNDF"/>
    <dbReference type="OrthoDB" id="6412219at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="310" mass="33115" checksum="57ECBE6797858E69" modified="2014-10-29" version="1">MASVAGAGASLLDKLDRLVGSTVLHEARVYPVPTVPPGGVSHPATAGFGEVSGVGTSTSLTTPPTALTTVVQTNDFVVLPGPEDVLLLNTTTGLYQQSVTLTARMYPIEATAAKSIWGLPTLIWGILIGTVVILILILATLFFCCWLQPRTRKLLNSSYYTTAANNGNASQSSIVAKSCTSSDSNQLVMPLSIGICPPQYSAPPPPNASQQPSHPSPMINDESEGETGTSYRTRSLPSWGKNKQRPLSNADDLEELYAKVNFSKKRRNRMRNDEAAIIALCRSRSQNLSALPLAATEQDAVVVYDERTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWB9</accession>
    <name>A0A084VWB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009649-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWB9"/>
    <dbReference type="STRING" id="74873.A0A084VWB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009943-RA">
        <property type="protein sequence ID" value="ASIC009943-PA"/>
        <property type="gene ID" value="ASIC009943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009943"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004263"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF457">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009943-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10264" checksum="8DA81367992F7612" modified="2014-10-29" version="1">MAITNTAATLSGIIVPIFVGQITHGNQTIGAWRVIFFVTIALYVVEIIAYLLLASGEEQPWNKGDKPASSIEAAEAEATPLNTKESKQNYNGQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXK5</accession>
    <name>A0A084VXK5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005285-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VXK5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010437-RA">
        <property type="protein sequence ID" value="ASIC010437-PA"/>
        <property type="gene ID" value="ASIC010437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010437"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006451"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009861"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020561"/>
    <dbReference type="OMA" id="TYEMIMV"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="477"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="528"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="602"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="917"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1330"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1539"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1655"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1868"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="2044"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="2269"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="3514"/>
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        <location>
            <begin position="2666"/>
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            <begin position="2771"/>
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        <location>
            <begin position="84"/>
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            <begin position="104"/>
            <end position="122"/>
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    </feature>
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            <begin position="282"/>
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        <location>
            <begin position="422"/>
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            <begin position="565"/>
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    </feature>
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            <begin position="672"/>
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            <begin position="683"/>
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            <begin position="705"/>
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            <begin position="1914"/>
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    </feature>
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    </feature>
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            <begin position="3331"/>
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        <location>
            <begin position="3536"/>
            <end position="3546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42699.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3562" mass="382316" checksum="C95ACB59CD0D6ACB" modified="2014-10-29" version="1">MNHCQPAANETDKILARTQHHQLYGEEESLYQKGTGGFSTVGPSPMGGGTNEIIIQQNIPGQVVNQACQTQISSMIAAAGQMKSSPSDTLSSPSHDSIERKKSSGGGGSGGGSSSSGGGGGQQHTLKSPVTKRPANAPVALSGWLYKQGSDGLKVWRRRWFVLSEYVLYYYKGQEEEKLLGTVLLPSYKVSACFPEDKIYRKFAFKCEHANMRTFVFAAENGEAMSQWVRALTLATMMIQQGEAEVQQQPYQQHHGTKAGNSGQGELVSSDSSGTVGGPQGSQGSNDTIKLIQQASSGSSGSGGGLGASHQGPNESMPLPQPLYANAPPKPRRVNDAGYSSPSPEHTILHDRYEQMMHQHQQHQMATPGQFAAAASGSTGLLVNRAGGQQTVLTANAIYGDPKRIERDLYIQKLIEQQQQLNATKQQQQQQQQGMQASPMHGQMARGGAGTNPFLYPSNDRRTPDTYGPPGNAGIDPKHMSDYEDIYNLTMLSKSLPTNAGSSALMEGEAGGAGATGYKRPTSPQHYGSNGAFPPFKANTTATMYSANPFEMRARPIPPNIPRPHSADFLDYETRHPMNPAASSSTNDEPSPALRTPRPKASYAEKMRLQSASYLQRANNAAAASSVGASRKQRSDDVQGLFTGGTMPRDGLYRSGSGKLLATPQQQQQQHQHSEADYHHPEGSQSMPRPSTSDRPTGGGGGRPSVSSLKKQGFSHQQQQEQFARSASARLPRKEEDASLRDGERKREESMKRLLEWKQRMLQSPLTKKITSQHSASMASAESLDPGSHASLIAAERRHEDIYGLKTSDSALLRGDYYATNYERQSTGDLTGVGAVRGGGTTDRHSGSTLNIAQQAAYGSEMKLNGDYNSYSSDDEGSTEVGASSGEAADPRLSRTGHSKQEHLDEDEDDGRDEKGQEKVAILFPALLDDGALVGKEEDEEDAVYEDSLVNHASASASPNLSVDANVYENSFIKAMAPKEDRKEAKGGRSFGSAERHERAKELFERHVNNSSGNGRGLGDPGRVKDNHSSINSGDGTGNGKFSLGSRTKMASPGPVTAYVPVYKQTTPLSMVGSLQSKPNDDNDDVLPEANSRLDVVGAIEGQVRGEESAGEDADDGDDIFEYTDEDLDEALQQHDATTDQPSSDSVNQDHPPFVREEIDDELSLQILEGHYMPMTPRRSVISSATSLTTLAMMNRANSNISGSNQPPPAPGGGRLRPCESLTAMDILDSIQKSSNEMQICSSNAYDESTYIEMTKGTLGKSVFADDLAGNGGGVATTYEMIMVPPSSAGGGTKDGEQFGRSDHERAKLIDSEPLYMELSQLHSSISTLKQQEGEVKVKTPHNNSGSVEGKDQSEKTGTIGRRMKNAMGAGAASGAAGLGKKKKKDKNNWPDILMQSSSNKSDDSDSDSDVVSKQVNNDSGEGKQQARAGKKKGAGGKEKKMSSAGGGSASVTELLSGKTASARSRFSLSDTFRPASYYLGASSGGGSAPYGSGVGQGATGSGADTLLDSSDSEIVSPPPIPISSLPLDEADGGGARGEDMAGMMMARYGSRERFRSSDAIDLIRSHAQEKRQSVQSLLAGLGNGGDGQGAYSRAGAGLRRESGSMSSNRSSIIFGTPNHHHLVRHDSPSFGHDRSYDGVSNASSEYEILLRGEGRPGAAAGGTPGRGDDSSTRSSITLSETSGSIEWRSRSCMDVSVRNKRRPISGSSMNCSIEMALGGGDFEGSVASSQQYDRAVELGDDGAPGAGAPGGGEYSMHFLSNTSSNLSQNGHDNSIYYENVEMVGGVVVESSPSSRPPSSVAGGTTILSPLREKNLSLHDARCQSEYLGTVPEGHSLDVDSGSLSSAMDLDQRSSCTVRFDYARSNMSNRTITPTDGGGGPGRTVGVGTTTSHSRNNSTLSSEGAPYYYSDLQARTEEQEMEEQQHVGDGQQPRHRRTTSNDRGGSSNGSSRAASAAPSTTSAMTPLRAGGDTLNNQRDPGGLRRQAAGIFHIHNPLTNTLKTANLLLHASATEKHADIDRKNIYESDRIGQKDVNKTIAASLASTSGVASGSSTLTRATSSSSGKGAGNGHLQLHHRRSMGSMLQVSSSSVGDDSGDDRAPSVSGCSNSGNNSSIVQQLLVSAGHISSGDQLWEEDTLWRDNLRRVSHIHAKSMDNLDHLGVGGGTVRSTPSGVVLAKTVNYHHHQPERMGDDDIGSEVNMEVKKPTVKINRKDVTYVNENLKAGVSGAQPIVTKSILRTSTTRSESQGPVNTGDDDDVYVQLASNVASSDTTARDGRWSSLQPPQSQPASDEVYEVLRDEVSRYDINRETIRQWDLMSSGLVNNGSPNYGKGTMVPGQSYAGNNGSANSSAISSAVAGGPGANETGKQMGLPPVGTSFYHQPLSGSFSNASDLLVDQQNGVRFNTSSVTLPVVGSGGTIERRAKVPNNSKFSSTTSISVRNVFNIPKVPLTVKPDPSDPSYLAAVGKQHHQGGGYYDGTGGGSMMLDYPGGEKYIRPDISFESTHDLYTQAQLQRAQELNLQQHYQLQNIDRSLATMQDQQHPDAVSPQSPMVAGAPSTTTTTTTGMDEKWSNNGMVVTGPSAVAALGVQGGHLYDRHKHGSSSEMQPLDVSAGDLLNRTHEELILLLIQLRRQNSQTARSIEQCCTNMHALQNLIRTAEGERKADSLARLDALKQQLTELEKQYEKEKPLINLVDNMVKLGSLYRGPVGGKKQLQSPESATLDRLEFNQRIQERRLLQEEQRQWDRTSPNHVELQSKVQQLYQIDKLMQEESGTLQALQRDKENLEKALAMLKTRVLNREGGSLPMPMDNARQQQHNLERELSRVHQLLAANSKKLEKTVSTNARLEQELLVLRQKLQATREHRSMHSVYDTASPMDGQYVTGSVTAVLESELKRAKLLVGDMQRQRQELGQAVRQLTSYSNADVGGGEQRHSEHGNPSEHKRDQSLKSKHKRSYSSSWVETDLDSTAGKDGSASSSVGSTAGHHRTMSSSSSSVLTIDDEMQNLFLPSGGRAHESSLDGAESMDELYSIGGGGGGGGGGVYGYGSGAGMMAIDKQQEIKTVRIVKRESERRTRDKEKNDRNLALSLDQVLEEEAQLMEDYQRAKSLPRGYETHELFVQGPETDGRMGGSLSAIDGGRLMMNDYYSSVVASANGNSYPVSLIDRQADLYTGHFEPGLLQSKYITNSPGSGRSATTSMATSYQEGMNYPTGTTGSSTGLKRKTESIQSLNAAGPEFDPVFQSEAAKQIINEMATGAGGNGSSGGSSSSTGGGGMLMATGETSGDSSGSGSSRDAKLDATAGSSSAGTSLTEQQQQQLLMQQQRQAQQNRQRRAVPKDKRRHHTAPHHVNAKSIELMHSENDMNKNNVNWRARDDVDLEVTIRPRSNAPDVVRSALGPREKISEHTIDKLLAAPSKILIPERYVPEQTPELSPEEKRRRQEKVEAIKKMLSDTPIGSGAAGNETGPNPVPNVEKKQREHLIQLNQILAQQVMQMSKIVAEIRRRASVEIKRRSGGAFGAAAASGGKPVDEKDNYESDLEDYDTDSPAEPLPLYQQRENYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXK6</accession>
    <name>A0A084VXK6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010438</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01018088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXK6"/>
    <dbReference type="STRING" id="74873.A0A084VXK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010438-RA">
        <property type="protein sequence ID" value="ASIC010438-PA"/>
        <property type="gene ID" value="ASIC010438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010438"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020479"/>
    <dbReference type="OMA" id="QSHATIC"/>
    <dbReference type="OrthoDB" id="10014838at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase MGRN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="827" mass="86019" checksum="20F95F853E8A9033" modified="2014-10-29" version="1">MGLFASRQNATVEETDVSLNHLYKYPPRTGNYFGTHFIMGGERFDTPQPEAYLFGENADLNFLGSKPTPFPYPPPQATEPTKTLKSLVNIRKESVRFVKVSEGATPINNGNGVSNGYNIEFVFDADHACLITIYYFCIEDIGAGGLNYISRDSSMTSETFHFQRGVNQVFSAPHHIIYPALYAEDDLSYNPEKDTFPVVIHCVVGDGGSAAPTATTGASDVSTEASASRQSHATICVIDHHSDGTYALRALKQKIFVDGLYYLLQEIYGIENKLTSKSITDEETEDNGSECVICMCDTRDTLILPCRHLCLCNSCADSLRYQANNCPICRAPFRALLQIRAVQKDTGNGLPCGGAPAGQNSTDGADNIPAGYKTISLIEALNGPTVSSKVITSGNDAPAPTDTGSDNNRSTENGYGFRSKMTKSSTDHSSNGELANGSIVSEKSPADIRMHLLAADGDGGSPVDGTETSAGVTNPTVSTKKELLSKHSPLLQRAPVSKDKNPREKGSLHRIGANGGVGGGPNGPGKSKSGGDKSIAFQLVHEKTVAAGAGGGGGGGPALGLTVGLPKPADTKLTTDANENDDDSDGEKLSPLLRKSSDRSDSKKSPHGGDSAMKKLLTGGGIGGSGVGSEMKTSPSTVITELLKGAIIGSDDIGGNGMVGTGGARPGAGGGSIITIVADDSEDYYTPEDPPATSPLKTIDDDDELPKLAVEPDVGRKLLSGSVGMPMPSLTASSPTSAPAPAPPSALSVLKEEFSQGSLPDSPISGNSQTSTRSSSDSYSSSSSTRQLLSSGAVANDTPTHVLSSGDSTTNGHSGASKSIECSIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYQ6</accession>
    <name>A0A084VYQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010784</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010784-RA">
        <property type="protein sequence ID" value="ASIC010784-PA"/>
        <property type="gene ID" value="ASIC010784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010784"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14754" checksum="C657F5FF4E9FEA14" modified="2014-10-29" version="1">MSVTESRLVGESLSPASFHLERGEEVVGGRCGLPVSLTRFEGDRERLCGEGSGVRWLPIRTGNTLPFAQSVTIPTKFIHRNRSITGFCIRRVLVFGVATGGNDGEEEWLKTNDLFGVCYWLVLRIKTFRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZP3</accession>
    <name>A0A084VZP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Laccase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011233</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525252">
        <property type="protein sequence ID" value="KFB43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZP3"/>
    <dbReference type="STRING" id="74873.A0A084VZP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011233-RA">
        <property type="protein sequence ID" value="ASIC011233-PA"/>
        <property type="gene ID" value="ASIC011233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011233"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018052"/>
    <dbReference type="OMA" id="QAWQGIF"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000079">
        <property type="entry name" value="Laccase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000031">
        <property type="entry name" value="Laccase-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="297"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="418"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="759"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="940" mass="107367" checksum="409F7DB6DC7700CA" modified="2014-10-29" version="1">MNQHQNCDISKCPPLSNISEVSLEPGQRVRRELDPCCEVLRLYCDPSACPPMVEFCDAERTIRPRTVPGRCCTLQRCDNFCETYTNGEVTMRSVGEKWFNMVNASTCVNYECLRNEANETFINSIGIECNTTCPEGFEAQLSDNHCCPQCVQARCKFDERFYRAGESWESPDGCLEYRCNKEDGFFAISSSRKQCPPVGNCPTQDLVDNGCCKVCNRTDSRAETSRTSPLEEDVEGVDFFDEQSYRDHPCRRECTLGRRPETCYYRFRLEWYRTLSKACYNCPQNRTDCDRPHCIAGDGVRRNVAVINRMMPGPAIEVCENDIIVVDVENHLMGESTTIHWHGLHQRRTPYMDGVPHVSQCPISPGTTFRYTFRADNPGTHFWHSHTGMQRGDGAFGALIIRRDNDIQQLLYDEDLSEHVITVQDWGHEQGVSLFAAHHHSTGDNKPPNLLINGRGKYFQRFSKIPIPLTPTEVDIDTTTLPSDDVELLQASSNNGLKTVLRSQDVRHRMKRQSRTVNFNAVVVPESRHIPLKVFHVDKGRRYRFRLINAEFLNCPVELSIENHNLTVIASDGFGIQPVDDLGSFVSYAGERFDFVVKANQPVGNYLMRFRGLMDCDERFTSAYQFAVLRYRGAPEDVEYESWPPYDYEAPGRQLNSLNRGPGAEDVITIAETNSLDQEDLLLLRNETDYKFYVYYDFYGKDNPHFHVPNLYGFGQVINNTNRLYTPQLNHISMRMPPVPFLPGKDLLDESQFCNETTVRNRNCRNEFCECSHVIQIPLHATVEMVMIDEGYTFDANHPFHLHGHAFRVVGMDRVSRNTTVEDIRAMDEAGLLKRRFKRAPIKDTVTIPDGGYTIIRFIANNPGYWLFHCHIEFHAEIGMSLVLKVGDRSEMLPTPANFPTCYDYKPELGQLGSGASMGIPLYRLTILLLLCTILAQAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZS1</accession>
    <name>A0A084VZS1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP004761-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011266</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZS1"/>
    <dbReference type="STRING" id="74873.A0A084VZS1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011266-RA">
        <property type="protein sequence ID" value="ASIC011266-PA"/>
        <property type="gene ID" value="ASIC011266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011266"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002078"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13128" checksum="7B813306CD50464E" modified="2014-10-29" version="1">MNGTGKYPKPDITAALEAKKVTKNLDRMGTYGVDSMIDIVMTNEQRLIKANAYAKSRMATAAMPPNPASSAVVSKLSGNYNFKLRPNTGVTPMSCNTHAAGVARETNRCQSNIGGSKTCSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0F9</accession>
    <name>A0A084W0F9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0F9"/>
    <dbReference type="STRING" id="74873.A0A084W0F9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011434-RA">
        <property type="protein sequence ID" value="ASIC011434-PA"/>
        <property type="gene ID" value="ASIC011434"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011434"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013820"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021627"/>
    <dbReference type="OMA" id="RICWASS"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="226"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="542" mass="61192" checksum="D643D5F127A1D262" modified="2014-10-29" version="1">MVKKVNGSDNQCMHCVAQGDENACDTQGESLQCNRELAERYLNIFSRLNENIDVEKADKTQFKCFKFKMSGQEDYYMKGCTYQSIPLCDNILEGMACSTCEPANCNMHHYSDYYEDDSDKVVPREASIAVVSICLLLVRVNQRARVNASLGTKVCLFFPAEFRNEKNYRELQQVFVKGIGLQMIQVVRICWASSVWLLLAAFAARSSASSKCPLEEGKTPGAVRRVILDLDAGGDDAWALTMLLMNEEKYNICVQAVTCTHGNAQVQDVEVNVLRILEALGRLDVPVYVGAKEPLITPSPDRKDSHYFWGENGFGDVDFGMKPVKRIQTPEHAVHKMNELFQRFPNQISLLAVGPLTNVALLYKMYPEVKDKIASLYILGGNRHGVGNTAFAAEFNFFTDPEAAHIVLNNSPMTVQVFPWETVVSLMSQFSTRWRFETFMKTSNPAIRVLNKVEWEVYAQEDGWTPCDMYVAAVFLNRSILESVVKYRATVELNGRVTRGMMAILHHVTDSEQHNVAVIDKVDEEEIRQMLLSLNSEIKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0K2</accession>
    <name>A0A084W0K2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">39S ribosomal protein L41, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011482</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0K2"/>
    <dbReference type="STRING" id="74873.A0A084W0K2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011482-RA">
        <property type="protein sequence ID" value="ASIC011482-PA"/>
        <property type="gene ID" value="ASIC011482"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011482"/>
    <dbReference type="OMA" id="CQQRTIS"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011482-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17944" checksum="F374205340259AEF" modified="2014-10-29" version="1">MFNIIKRGIATSASLAGKRNFRKFLLYNKRGTRIFKQQRAENPDLYPDMPIDKRGVRDVGVTIDGKFITIPEKIPELIVPNLEGCKFKPYVSYKAPDVVQSEFTSQDLFNAIYAQKIIDDWKSGKLNEDGSPVEPSKEEALSPDEAWKQARKTGSDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0Y2</accession>
    <name>A0A084W0Y2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005972-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011609</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0Y2"/>
    <dbReference type="STRING" id="74873.A0A084W0Y2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011609-RA">
        <property type="protein sequence ID" value="ASIC011609-PA"/>
        <property type="gene ID" value="ASIC011609"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011609"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010558"/>
    <dbReference type="OMA" id="VDFNMSA"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000170">
        <property type="entry name" value="4-nitrophenylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF4">
        <property type="entry name" value="RE04130P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011609-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="319" mass="35797" checksum="18703AEEA823D089" modified="2014-10-29" version="1">MENNNIKHILQLSKEERRAFLDSFDTLLSDCDGVVWHFTGPIPGVDKALQLLRADGKKLAFISNNGMRTMAEYRKKFQSLGIEAQPEDIVHPALTTVRYLKSVNMQDAVYCIATEVFKDYLREAGYLVLDGPKERFPVNREANQVRVYSSYFDQHDAGPKVGAVVIDIDVNLSLANLMKAKCYLERNPDCLFIAGATDYIIPLDSSMDVIGPGYFIDILERTTGRDALVLGKPGKALAQAVRKKFQITEPKRVLFVGDMLPQDMGFGTRCGFQKLLMLSGGTSKDVLLAHDEPDELPDYYADSFADFIELYNDSVRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1K5</accession>
    <name>A0A084W1K5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NFkB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011935</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1K5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011935-RA">
        <property type="protein sequence ID" value="ASIC011935-PA"/>
        <property type="gene ID" value="ASIC011935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011935"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9657" checksum="D6A03A34B3502229" modified="2014-10-29" version="1">MEDLGSSDQKLVSPENMNEIVEEVAPPDSGDMLTENRENENSRNLMDTIIDMKCCGGVECRDCSCGKFLWRVHCGHRDHLLSVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2H6</accession>
    <name>A0A084W2H6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005319-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00012202</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2H6"/>
    <dbReference type="STRING" id="74873.A0A084W2H6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012202-RA">
        <property type="protein sequence ID" value="ASIC012202-PA"/>
        <property type="gene ID" value="ASIC012202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012202"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008898"/>
    <dbReference type="OMA" id="CTFEPIL"/>
    <dbReference type="OrthoDB" id="430300at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012202-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="511" mass="55172" checksum="64C35EC810D8070B" modified="2014-10-29" version="1">MNADTRRFSSGEIHCSDEDTPLLAGPRDSPMAATTSASPGTRVPGTAPDQYCTFEPILVLLCFGLSVSGVVLADQIIYQSCVVTLGYDRTLCAQLGTRSNSSEVANLETIVQPYAAKIGMVNTILTSVLPAICALFMGPWSDKFGRKPAMIVPSVGFITTYGMIGILSLLSRHYLVDPWCYVVAHIPAAVLGGNTVLMAAIFSYLTDITTESNRTVRIGILQACIMLGAFVGLLSSSFILELTNVPTMFFLSAGAVAASSAFLYYFLEDSIKPDASMVHRQVRDIFRLSHLGDLVKMFFKKRSSYDRGIVWLTIAIGVVTVLGAGGGTVFFLYTRRRFGWTIQDFTIWQAVELLSIVAGNVIGISVLKTLLKLPDVWLALISVVNYALDALIKGLARQGWELFLATGVTPLKATEGAALMAICSAIIPSNEIAKFYSIAMAMTNTVSLASAPLFTFIYNSTVETAPQVFNFVASGIFSVNVIFVGIIAVLLRKRTATRADPLCTQDSEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2M3</accession>
    <name>A0A084W2M3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012255</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2M3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012255-RA">
        <property type="protein sequence ID" value="ASIC012255-PA"/>
        <property type="gene ID" value="ASIC012255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012255"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17325" checksum="6AF31ABF836BC9CF" modified="2014-10-29" version="1">MVGKVGKKPLETHGTEGGGDGRVGERAVRKFSAADERTCIAVPYYYCSGQRLHTSYGLTALALRLLAHSRPDFTAHGRRTVFTHDFPAFPPMAMGEFSTFQYGHFSFRHGDSNAYSTDVTTENFPSFVQPMTLCIYTHTPIHVQRSVESDTCASATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2T0</accession>
    <name>A0A084W2T0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">DNA helicase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012403</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525277">
        <property type="protein sequence ID" value="KFB44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2T0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012403-RA">
        <property type="protein sequence ID" value="ASIC012403-PA"/>
        <property type="gene ID" value="ASIC012403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012403"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="11141" checksum="7251F97C8DDE4663" modified="2014-10-29" version="1">MASAIFSSRFASLLTRPGPTGTWSGPRSGPIDRRGLEDFLYGLARTGEHTHLPHRQLTRPRRVRRRPTIDRANVSGRYMAISERRKLFHAEPSRLMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3S6</accession>
    <name>A0A084W3S6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">KID repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525294">
        <property type="protein sequence ID" value="KFB44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3S6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012781-RA">
        <property type="protein sequence ID" value="ASIC012781-PA"/>
        <property type="gene ID" value="ASIC012781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012781"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759949" evidence="2">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="20176" checksum="BE41855629C955A9" modified="2014-10-29" version="1">MGARVCLLLTCFVAFWSALVLPPACGFGIDDLMSRLNFIQDKLQDIEHGVNKQHLYAEHDRQAGENRLDQPLAQEQVAPGLMEKLESLERKVNGSEASLKQKLDSIERSLQASMKALEDKMDRVVDDMKTRENTHQDELRAMENILVSKMNQLQETLRNEVPQMQNQRAIMVRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3W3</accession>
    <name>A0A084W3W3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012819</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3W3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012819-RA">
        <property type="protein sequence ID" value="ASIC012819-PA"/>
        <property type="gene ID" value="ASIC012819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012819"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="28148" checksum="9E8D295524ACF54E" modified="2014-10-29" version="1">MPYRDRVNPLSPCNDAKQTKPIARKWPHVSARFHLLKESHRRRPPINCEDIVVTQEGDQVIAGSGFFLPRTRIRSSRAAYLLASEGGCRNCQSRRTLPLWGLSKNKNLHWDDVTTVQWMHANATGNRVNEPSPEGCSMINEGEVKMIEPSISIGTWKSQEIVEVRRMLDCDLQHHHHHQHHECYQSNSKNNRSWPAPTTGRFSVERNEKPLAISPFVCFVRPRLSSGSFALHVFAIERSLRLKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3Z3</accession>
    <name>A0A084W3Z3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012848</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525296">
        <property type="protein sequence ID" value="KFB44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3Z3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012848-RA">
        <property type="protein sequence ID" value="ASIC012848-PA"/>
        <property type="gene ID" value="ASIC012848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012848"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022237"/>
    <dbReference type="OMA" id="DKCECNR"/>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012848-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2189" mass="235763" checksum="6027B47FBAEFE249" modified="2014-10-29" version="1">MFYCNRDPAKASNCSKSSSTSAKAHGPYHQPYSLLDITARIVAQNEPFQKIEERYDRIPEPVQRRIVFWSFPRNEKDICMYSSLSRVSSINSVESQSLSFCTGLKLVETGCVENVLQVGFHLSGIVWSHPPNQSERHSHGSGNHAGSCKITSVTCSCDTKDIFWCHHVVALALYRIRNAETVKLRVPISETLLQMNRQQLQKFIQYLIAEHHTEVLPTAQRLADEILQQRSEINSICGAPDPTAGASKDDDHSWHLDETQVCEAVKTYLGQGSYYYSSKHLNSLFGKVREMLRAQDSNGARMLTLITEQFLNDPRLVLWKNHGTPMTEKCRQLWDQLGALWVCIVLNPKSTQAERMHWKALLEKWSKSDVCPQEDPDLRTSPSSSNRESVRDRSNRERERDRNRFFRENNLRNMMHYNHHHQQQQQQHHQQQQQHQPALHNNHANGGGGAYLGHLQDNPYRMQYNHRHGGGAMRNRLGGDNGNRGGNNHHLNEQYDSSETDSDSDEEMDEAIEEGGAGGNGQEEEEDGNENENENEGGNINGHRGRRLGDDEEDHHEDDVVRAGGRRGDDGMEEDVVDQVHNILQDINFVDGVEQAERGVGGSRRGAHHDEDGEVREFMNLNLLNVPEEEHRLPEMLPENDDSSRESMDVDEPGLIGGPVSGSSVSVVDGTGTGRTGPKVAPGGVGFFPSPCICGEDKCECNRPVFLDDIKPKKFFDCVAAAAVGGGSSTGGGAAGTSAGTSMVTEPSAVPNFDVSEDANQECIGLAKEEVDSEVISGEISSATSSKRHASDDAIEAIAGPSSSSSSSSSSSSSSSSSSAHHRVDEELDFEKPGPSGLNRHRRMEIADDGARPSTSSSAPVTGGHEDCDEDCDEDEKNKPSCDKPNDAEVAGPSGISPFCVEKQQKDAQKDELDPDAGPSSRRSSTEGAGSAAEQAGIANAPSAVAAGGSSRAKQVNVGDGGGNAGAGGRPCKRLKLNNGSWVSKNTNKTPRTIFHKALDAVSMSWDNEHLKRILESDSYKLSSINSVQIAGSSKAPVANHPSAKSNFNANGQPLWHEKISMTAARIDSLRSHGHMEAALRLSVSVVRTMREIQREAQALWLRHKPKMPQQQQHGALPANLRLAHPDPWVRLLRESSSSSSSSSTSSGQRCNCIPKGLIAEPSSSKQTPSISLPSSSSGSSSSVAQQQQHYGHQHHQNQHQHHHHHNHPQPSTSSEVKSNCQCQTHRQQHHPSVSFHSGTPAPGMMPDHHQHHNHHHHQQQHHQQQQPHPSTSSEGKSGCQCQLHRHQAQHQHHQHQPPPPPPPPMFPSGPMLPDHHAAIAPMPSTIKKDCSKCLQIKCYYEMVGSSSSSSSSSSSKHNNLAPGGCGGGPSQMPQGAAIHHNHHPMGPPPPPPPPHPSQGAMPMPSTSGQQQRLHRSSSSAGIMCNSSKCGPFVAGGSSGSVGCGVPPQQAPEMYRKMMHCSSAASQQMPQPSSSGLQQQQQQQQPHCSRDYPYMKLAFVRGKPMIVPVGGMRHPQPSGGPVQQPTPSTSRAQIGQIVAPSSTQSTTSTTTTTAGSSGVNIPPAPSTSSGGPGVSASGSSTSSSSSSASASVSTSSFQPKCNCPIHKEEQSASSSSGHSSSAALGAPPAPPLPPPPCNPIDGAGPSSMGTTVSCCVKPICCSLAMPVQHHKHQHLPPSYAPASASMAPCGGCALHAGPPQPPPPPPPGAIYGGLYGGPSSSLSSSMPSCSNSKPFDSRSAAGVSSFNASDCDMMGPPNQHKDDCPMAFGKSKAHGSSFSNGGNVCASSNRSTTAADTNAAATSTAFLEPIKVNRKPNCLSKCIDCSVGCEVEFPLDAIACIFDCLTEASLIPEAVTVQMNEMSRIAYDAGNGGAGGAGGGGAGGGSNGNGAAAPEDVNIIAPKYRHLPIADSADRQETYLTLAFEAAILALSKQRIMPHGLYAQHVICKQQDQLIQRLRSIDLDTMLVSVLRMLSLQLLDGGPTSGLGEMIHPESVPMHTLARFLFASLLNQYPDLAFEIGLRAMRFPILENINEGSVNGIELQHNNFMHSPYPRWWTLGHLETQQCSLSSTMLSAAKGDTKRLSAVLQNARRNIHSSSHLFRLAQDAFRFATPENGPRSQTLLGVAFELGLQVMRMTLTCLNWRRREMVRWLVTCASHVGIDALMSIMQNWYVSIIRCTGYVLCSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4K3</accession>
    <name>A0A084W4K3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013102</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01020343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4K3"/>
    <dbReference type="STRING" id="74873.A0A084W4K3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013102-RA">
        <property type="protein sequence ID" value="ASIC013102-PA"/>
        <property type="gene ID" value="ASIC013102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013102"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005173"/>
    <dbReference type="OMA" id="DKKLHCQ"/>
    <dbReference type="OrthoDB" id="253091at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF5">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="25130" checksum="E7EE92621D5825D7" modified="2014-10-29" version="1">MIHCFPLPLLPATFQYLTHYRNNDKMAEQTTGRQLQRILHYSVTPCRPMLGLRRSECALYDVDCDEVYPRLYIGDANSAKNKQYLRLIGITHVLNTAEGTRFGQVDTGHSYYRDMSGIRYMGFPMIDQPTTDISRYFYIASKFIENGINSGGKVLVHCMMGMSRSATCVLAYLMIARKMSAAEAVRTVRMHRDIRPNEGFLQQLADLDNELKRDQLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6W5</accession>
    <name>A0A084W6W5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Shootin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013924</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020996">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6W5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013924-RA">
        <property type="protein sequence ID" value="ASIC013924-PA"/>
        <property type="gene ID" value="ASIC013924"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013924"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013924-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7718" checksum="85F293F7D99D1BA7" modified="2014-10-29" version="1">MSPSAPPPHAQEGNRPSKATEKSKFKSYPLPAREKCAHFSEFSSSAGAAVRFAFRICAIFDADCDRVDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W727</accession>
    <name>A0A084W727_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002650-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013991</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W727"/>
    <dbReference type="STRING" id="74873.A0A084W727"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013991-RA">
        <property type="protein sequence ID" value="ASIC013991-PA"/>
        <property type="gene ID" value="ASIC013991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013991"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008659"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF2">
        <property type="entry name" value="IP09356P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784569" evidence="1">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="296" mass="33681" checksum="93B069D9B535F4A2" modified="2014-10-29" version="1">MHLLLVKVDLAVSGFTVAEVITPEVILEIQFGTIGEGVVSHRDGNTNIHSHAVPPVPEISETYARQQDSNNTPEPFPEPVCGQIAQLLDRCFHNYTPSVAVELLHSVQIPETVEQIDSRCVLFDRGMQCVERYLEACVDGKERLIIDNEVYGAKRLYAFLCRDRGFQQEFLRHKGCFQYVHHDLDECSKEFVDILKVEIARTSQQSFNLQYMHFCCARYAYESCVYQSARHKCRPDSAVFLRHVAKLLSTDRHFANCDKIENEICSADRPTWGTLWALVVSVGLLLPSLVRNVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W755</accession>
    <name>A0A084W755_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013113-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014023</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021112">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W755"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014023-RA">
        <property type="protein sequence ID" value="ASIC014023-PA"/>
        <property type="gene ID" value="ASIC014023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014023"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019408"/>
    <dbReference type="OMA" id="MVDWNIE"/>
    <dbReference type="OrthoDB" id="7733935at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF0">
        <property type="entry name" value="DAEDALUS ON 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="361" mass="42183" checksum="A93C0017E65DC047" modified="2014-10-29" version="1">MYCFRLKSDAFLYAAALCVLLWTIYQEGSAQFIFQSETNATHSLRVTKIQCVDVPYKRTTLNYCRMGTFPNKTVFINASLHVPMPLNYILLSAKLFYKYTAYHPFMVDWNIEVCKAIKYPNRQNLITKIAMKIAEDSVPHMLYNCPHGNRTYSAVWLYPSKFIFTTIPSGDYRLDLRFSDRDEETLLALQTFMVSETNATHQLRVTKIQCVDVPYKRTKLNYCRMGTFPNNTVFINASLDVPMPLNYILLSAKLFYKYTAYHPFMVDWNIEICRTLRYPKRQTVIAKVAMKMIIDTLPHFAYNCPHGNRTYSSVWMYPSKFIFKTVPSGDYRLDIRLSDRDEETLFAIQTFMAVRKQGIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7C5</accession>
    <name>A0A084W7C5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014098</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB46119.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A084W7C5"/>
    <dbReference type="STRING" id="74873.A0A084W7C5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014098-RA">
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        <property type="gene ID" value="ASIC014098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014098"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13781" checksum="6D574D91D22FEDA8" modified="2014-10-29" version="1">MSESVEMELLINCTQATIQRFPWSTDYNTTVISELNRTEILDVLGEMITKSRSYVPKSDDLLTLSALGQSLWKAVPESLQDTFLANKHQLRPHETAQIESSSSAFRTSLASVVIARVYPIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7P4</accession>
    <name>A0A084W7P4_ANOSI</name>
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        <submittedName>
            <fullName evidence="10">AGAP008642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014126</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7P4"/>
    <dbReference type="STRING" id="74873.A0A084W7P4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014126-RA">
        <property type="protein sequence ID" value="ASIC014126-PA"/>
        <property type="gene ID" value="ASIC014126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014126"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016336"/>
    <dbReference type="OMA" id="SCGAYKR"/>
    <dbReference type="OrthoDB" id="10046582at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:side of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF27">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
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    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014126-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="16808" checksum="426B6FDC0A814F9A" modified="2014-10-29" version="1">MNNLMKALLVTISIGSATAIRCYQCSSQTDPIGQDNCGAYKAFNVTQNIAIECNSEESHMPGSFCMKVVHQSPRGFIWDGRWRQVIRQCASVSETGVTGVCNWGVYENGVYWEECYCVEDECNDAPKTVPARYAVLCLVLLQTFFLAKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8Q0</accession>
    <name>A0A084W8Q0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrator complex subunit 11</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC014633-PA"/>
        <property type="gene ID" value="ASIC014633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014633"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005462"/>
    <dbReference type="OMA" id="GMHIGYL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA endonuclease activity"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00753">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11662" checksum="6AFCE2A392F7E11E" modified="2014-10-29" version="1">MPDIKITPLGAGQDVGRSCILLSMGGKNIMLDCGMHMGYNDERRFPDFSFIIPEGPITNHIDCVIIFHFHLDHCGALPYMTEMVGYTGPIYMTHPRKRSLRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8R0</accession>
    <name>A0A084W8R0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP009928-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014644</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8R0"/>
    <dbReference type="STRING" id="74873.A0A084W8R0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014644-RA">
        <property type="protein sequence ID" value="ASIC014644-PA"/>
        <property type="gene ID" value="ASIC014644"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014644"/>
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    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:protein kinase C binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endosome organization"/>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <begin position="561"/>
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            <begin position="253"/>
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            <begin position="422"/>
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    </evidence>
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        <source>
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    <sequence length="756" mass="83622" checksum="51F551D9C23E87BD" modified="2014-10-29" version="1">MSMKITITVGGRKSNFLLLGEDVCKNLAEVKEFYSSRFQQLENEKGIKIFWKDQDGDEISVVKEADFRSFLLATGSEKVRLYVEANEETPVDPGPEHTGVLCDECEQGIVGHRYKCLMCVDYDLCMDCESKHRHKDHMMVRFPRSIKGTQSRGDAMRVSAWIDRMGRYAKKIDLLLSGAKDTEANGNGNGVDIDEDDDKIHGWGPREISFKVTRSMSAKESHLAQGKPKLQSNGQGKHKQQSMSKADAGASSKMREQPKRPKEKQVSSARSNFVGIFKHDPQREQSSNTASTVYCPQHNIYHVKRPLEKPLSTKDPKEPTSAANAATGVTQGQVSSKPSNTATGVKQEQGSSKPTSPTGSVVTGLVDGVLKHTPPEWNKFLPTEEEMNRLSSKVSGLLSVLGLEVTMPPTGGEAASTPSGSSKKETEPKTSEEEKDPQSGSMNSAKEEKQEKVAANNPPEIISVTKKALPETENVAVSASQDAEKLPEGKDEVQQLAMEKDDSSSDASSASMLTDDDEEVVEVAQVAEQNTSPQALPSRLEVPWIMVDLPDDREEEVKQAVANTTSAVPVASTSVEKVDDKQTPEETSPKQQPEVEEFYANTFQNMVDLVKQLTVDPKGAERKVSELIEGSQKEKNKLVQDDRYKAHLEKAAKELEKHLLEVKNKEQIERMQQNLPSPTKEQASPVRLNPMADAFTMSRTRAVPVRMYSRRPHVNHAVQTMITMGFSNQDGRLTHLLEALNGDIPRALDRLMQNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Y4</accession>
    <name>A0A084W9Y4_ANOSI</name>
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            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">ZHAS_00015044</name>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC015044"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784685" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="6845" checksum="54D1F7C5A88675E2" modified="2014-10-29" version="1">MAHRILGWLALLSCYGYVTAAEWGKKNVRDEIGEGVLCVVVSVVIEERSAHVLPRAASLPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBW4</accession>
    <name>A0A084WBW4_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Monocarboxylate transporter</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">ZHAS_00015821</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WBW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015821-RA">
        <property type="protein sequence ID" value="ASIC015821-PA"/>
        <property type="gene ID" value="ASIC015821"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015821"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022582"/>
    <dbReference type="OMA" id="YGALMSI"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF93">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015821-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="367" mass="40109" checksum="423D160BB04E8A53" modified="2014-10-29" version="1">MSLFSATIVVALCRRKSTRLTAVLGGLVLALGILFTSFATQLHQVAFSYGVIVGIGSAMVRESAAVMLGHYFKRRRQFVEMITMSGEGVGVALFSVILKEGVGKMGWRLGLQAVTGLVSFSFFMGLLYRPASLYHPQRRAILHLKNQRKKVKEKKTHVRTPKPPFLDFTPLKSSSVRMLSISASVAALGVYSPIFFLSLHGFSEGYDMQDLVLLQTFLGLSIALGIVFSGSSINKTLEISFRKVQISRQYVCQGCVTLVSLSLLVLSAVADYRGLCFSAWAYGLGLGGYRYTLKMLAIERIRGKYFSKAWGFIKGAESLPVLFGVPLCAFLNDSSHRYGRAGYYICAASAAISAIILFFVGYPDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC63</accession>
    <name>A0A084WC63_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015762</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022574">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015762-RA">
        <property type="protein sequence ID" value="ASIC015762-PA"/>
        <property type="gene ID" value="ASIC015762"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015762"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016960"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015762-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7098" checksum="FA7F9272DAA33D0E" modified="2014-10-29" version="1">MADTVIDLVNDSESEDVIMIDDQPETSEPKEEKQSMETNGPEEEPNASVNDADEVEFVPISQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEH6</accession>
    <name>A0A084WEH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP006376-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00016609</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEH6"/>
    <dbReference type="STRING" id="74873.A0A084WEH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016609-RA">
        <property type="protein sequence ID" value="ASIC016609-PA"/>
        <property type="gene ID" value="ASIC016609"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016609"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001542"/>
    <dbReference type="OMA" id="YDADNFQ"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB48620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016609-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="243" mass="27789" checksum="93F39FA2BB964561" modified="2014-10-29" version="1">MEFEMVHGKTSNNKDICGEDKHKEEGDPWSVDAHSAFLGPNLWDKTLPYDSDLKVHQYADLDEFLSENGIPYDGLPSSHLGNSTSLTGQRSDSLGHCAGLSLSGLSQVTTKRERSPSPSDCMSPETMNPPSPADSTFSMSSTRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDEMKDDKYWARRRKNNMAAKRSRDARRMKENQIALRAGYLEKENMNLHREVEQLKQENMELRARLSKYQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF17</accession>
    <name>A0A084WF17_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00016897</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01023286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF17"/>
    <dbReference type="STRING" id="74873.A0A084WF17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016897-RA">
        <property type="protein sequence ID" value="ASIC016897-PA"/>
        <property type="gene ID" value="ASIC016897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016897"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011661"/>
    <dbReference type="OMA" id="MEFHRFY"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="490" mass="55674" checksum="C48A795F7BBADBA2" modified="2014-10-29" version="1">MAAQPACTRFSDNYELKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTSRDFQKLEREARICRKLQHPNIVRLHDSIQEENFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLKKEPYGKAVDIWACGVILYILLVGYPPFWDEDQHRLYVQIKAGTYDYPSPEWDTVTPEAKSLINQMLTVNPYKRISAADALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSKSMIAKKGDGSQVKESTDSSSTTVEDDDCKARRQEIIKITEQLIEAINNGDYETYTKICDPHLTSFEPEALGNLIEGMDFHKFNFENVLGKSNKAINTTILNPHVHIFGEDTACIAYVRLTQYIDKQGHPHTVQTEETRVWHKKDSKWQNVHFHGSRNGSFSNTATQYDFVNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF69</accession>
    <name>A0A084WF69_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">PF06250 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017123</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF69"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017123-RA">
        <property type="protein sequence ID" value="ASIC017123-PA"/>
        <property type="gene ID" value="ASIC017123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017123"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11101" checksum="C169F8D6A87912F0" modified="2014-10-29" version="1">MRDEIGSIRANRARINYAIRESEPRSGFGMQSLAGHGFQAVKRLINLPTRQLSGSVAPAGRRHTTILEALEGDRAEFPIGSIVRLYTKPMVTGCTVLHRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF77</accession>
    <name>A0A084WF77_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein mab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF77"/>
    <dbReference type="STRING" id="74873.A0A084WF77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017132-RA">
        <property type="protein sequence ID" value="ASIC017132-PA"/>
        <property type="gene ID" value="ASIC017132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017132"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023472"/>
    <dbReference type="OMA" id="RESIYMK"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000002">
        <property type="entry name" value="protein mab-21-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="4">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00070973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="365" mass="41871" checksum="E97303ABDDAFA71B" modified="2014-10-29" version="1">MLVPPEMIAVQSKLIYQMNKYCADRVQARKAQIHKTIQEVCRVVQDVLKEVEVQEPRFISSLNDYNGRYDGLEVVSPTEFEIIIYLNQMGVLNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQACDKCSYRDSVKMIADTTEVKLRIRERIIVQITPAFKCAGLWPRSASHWPLPQIPWPHPNIVSEVKTEGFDMLSKECIALQGKNSAMEGDAWVLSFTEAENKLLQGGCRRRCLSILKTLRDRHLDLPGNPVTSYVMKTLLLYECEKHPREMEWDENCMGDRINGIFLQLISCLQCRRCPHYFLPNMDLFKGKSPGALENASKQVWRLTRIMLTNSRCLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFK5</accession>
    <name>A0A084WFK5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L40, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00017005</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFK5"/>
    <dbReference type="STRING" id="74873.A0A084WFK5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017005-RA">
        <property type="protein sequence ID" value="ASIC017005-PA"/>
        <property type="gene ID" value="ASIC017005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017005"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023710"/>
    <dbReference type="OMA" id="EDENTIM"/>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB48999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="22222" checksum="A074CEB415221D5A" modified="2014-10-29" version="1">MLRCRFSSQLGHTRALHTSSGLLFRCTPALCAEPLKKKKKLDPQIIKQREERKRKRLEKQIRRLEKNARQLKPIEELETPMELIDEQGKRRRASSNLSPELLEGRALLEKQWAKFKMQEKLADYQLFDRIVAAQTKALNELKLESEELYQQAIQPDPALVPFSAEGPVATPPINNYEQPDGEYIDVSKKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFL2</accession>
    <name>A0A084WFL2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00017014</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="ATLV01023372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFL2"/>
    <dbReference type="STRING" id="74873.A0A084WFL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017014-RA">
        <property type="protein sequence ID" value="ASIC017014-PA"/>
        <property type="gene ID" value="ASIC017014"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017014"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002423"/>
    <dbReference type="OMA" id="YRNPERM"/>
    <dbReference type="OrthoDB" id="6072411at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000019">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="473"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017014-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="596" mass="68778" checksum="3A0551BEB973C72A" modified="2014-10-29" version="1">MRVTNIRSGRIFRIAVGLAIVVLILYMIASWSGVDHRSVQDAYNARFAARRDGSGRVEQEDQSHPKEVPQLVEGLGNFEPTDLNPKEGPGEGGKAYVLPEDQQNRATDAEMEYGMNIVVSDAISLDRTIRDTRLEECRHWDYPYDLPKTSVIIVFHNEGFSVLMRTVHSVLNRSPKHLLHEIILVDDFSDKEDLRGKLEQYIERFGSMVKLIRNSEREGLIRTRSRGAKEATGEVIVYLDAHCEVNTNWLPPLLAPIHRDRTVMTVPIIDGIDHKTFEYRPVYADGHHYRGIFEWGMLYKENEVPRREQKRRKHDSEPYRSPTHAGGLFAINRKFFLDLGAYDSGLLVWGGENFELSFKIWQCGGSIEWVPCSRVGHVYRGFMPYNFGKLASKKKGPLITINYKRVIETWFDEQYKEYFYTREPLARFLDMGDISEQLALKERLQCKSFRWYMDNVAYDVLDKYPMLPANVKWGELRNVGMEKCVDALGRQPPANIGLQPCHGQGHNQLLRLNGAGQLGVGERCIESYNAEIKLSFCRLGTVDGPWQYDEQSGTLLHRTYKKCMGYQPQTRQLALMPCDINNAYQSWKFQEIQPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFQ7</accession>
    <name>A0A084WFQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">100k</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017063</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017063-RA">
        <property type="protein sequence ID" value="ASIC017063-PA"/>
        <property type="gene ID" value="ASIC017063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10307" checksum="220EF9EAE26F5A88" modified="2014-10-29" version="1">MVAGCWQYPCLEWSNFSQAPIAEARNLLIGDPQRNERLALADVRLIVVPIQVRSPSCLSGLPHLEHIAVYEVSSSFRYEAQMVAAQDGASVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG22</accession>
    <name>A0A084WG22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP009942-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00017324</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG22"/>
    <dbReference type="STRING" id="74873.A0A084WG22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017324-RA">
        <property type="protein sequence ID" value="ASIC017324-PA"/>
        <property type="gene ID" value="ASIC017324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017324"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020925"/>
    <dbReference type="OMA" id="YYVQPRI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB49166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="442" mass="48539" checksum="59F3E7E5033CAC01" modified="2014-10-29" version="1">MAPTRKPTDGLLARVNFPLYAIEMVTSRHVLVAGGGGASKTGVANGFEIYEIHHDGDKYVADEVIRHETGPTVVMNCAVKNDEKRTLLMAGQESHCQMYLVNTVIDCGDNLGANAASPGSNKTDTEGLRKRRSISQQRTSGTTPSVPADTEKKPSTGNQPQRKQIRFEIKTADSVQTDFTEAEPLQRVVRISPNGRLMATGGMDGHLRVWNFPKMTLRSDIPAHTKEIDDVDFSPDSKHIVSIAKDGLGVIWLINQDKESKKLVWNPPANCRYLLKRCRYGLVEGQKDKFRLFTLANPFAKAGKAKGLLQQWDPEAGRLTGVVEIDESLAALAVRDDGRFVAVGTMFSGSVSIYIAFSLQRVLHVPNAHAMFVTGLEFLPVTNFDGPSVTGDSEAAVLSISVDNRICVHSLPYRHSLPAWVAIFAIIFILFMTFCFCSYVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGK6</accession>
    <name>A0A084WGK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000126-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WGK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017354-RA">
        <property type="protein sequence ID" value="ASIC017354-PA"/>
        <property type="gene ID" value="ASIC017354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017354"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002609"/>
    <dbReference type="OMA" id="YIGCEPK"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17113">
        <property type="entry name" value="RA_ARAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1682" mass="183332" checksum="57AEADF2462008C6" modified="2014-10-29" version="1">MMQHGGMQDDSIKSDSPVPAPRPRQQITPLTPSVVEAGTERRYESVSFPNYSDTYVTPPSAQSSSGEPNRPIPAPRLRSRVLLVDAERPLATTEPYQNVVIVRPAPTVTPEKQLAKTNRNVPGAATGISTVPSKDAQSVPPLPGKVNNNLHTELADAIVTGEELDTVVADSIDSSAKDGEEAGTSRGENKYKTSSPADLFKTIGTTTRLLTEAIGERVAHKTKKAAQNVRTTGSSLVSWGTKSRGGPKGTGSTTEVSPELKRPQTLPSPDLMQNIKFGSPVPLNNAPSPGSVGSGLDAIGDGSQLTYDTPRRGNKPSNLRITPDSPSTAPSTAPSSTRASSSSMASSGVGTIGRFQRNVPVSQSLYGRVLPKHVRRLGSPGASCSNQPSNSGALVRSSKNKSESNLYESTFYVERPVPASDSVTHLYGKLNIIVRPSISSTSSSNCSTQDVADGAGSDEDNNLPELLRAGVQIRERNDTPDHESHTHPSSTRATYHSSPKVPPESLSTRLPTSYGPESELQNRSNSWNFYDIAGAKATDAEQPVPVHDEYEDEDGLSYQSSPEPVYANERHEPSSSIYDQLSEMESLRLLKPLPVAMGAVRHDYDEVSITDIIDEFDPLGRGTVTLEAIIENNGFGDDCKNAGASGVGGNLALIESLLGAESYSRQRIPLRSTGRTTVVPDTGDSPRPIPKPPKRSDSLLNNTTTPKPTTARVRSVPAKPKRKKSQQERESGSIIVHQNLNLPGSVENLVEVDERVIEPHLATFDDGPPAGNVEAADNLIYPMLPQTSWYLEEDGGGGAEGGACADSSRAAVSTRFEKQLNVDPLNERASVSGRSEKAAKTFLPPGLARPSTSAVGTKEDVPVPPSYFEAIGGTDPLFEHGLAATLAPAKSTSVAAKLLNALKRKPSINRGGSESSGSTAVRTALEMVPKPRLTERLISHQGHVLKFPSGKIGDVLNELSPRSVVLRERIFQTYLDPQQTLPKESLQLRFIMSLQCILQHKFAGDGRLDLHCFEIVLGVPKGGGGGDGGGGGSGGAAGPSGAAMSSTNPDLLITSGTSGNVKLTRQSYMFGTHKRSDRNLWMAKVLQSVTDVFGGESDLLREFLRAGWCYVKKSVSAGWAGAWLLLAKRRLYLYSFAEGRLEELDLRKARCIGMIENEPATIANLHIETGPSLFIDCPPYATLYFIMGSPRETQIWHKVIRQTAHKNGPTLHSQQLTRGDVPVLIDKCVNFIYAHGSMSEGIYRKSGSLSAVSRVLQLFGEDAFDVQLTRNEYNEYEIAGALKKFVRELPGSFFGSYAASFVAIGSLSCGDLQLKVDSYRQLLERLPRIEYCTLKKLIGHLAFIASLEKHNRMGVSNLAMIWGSTLLANASQNTVQEPGSYHQQDADVVADLIRLYRRLFPVNEDELRKDQLMLAVLQKYHAAAENLSDAVKHSGDLKVWITIDCDIPPEHDVQSPVNSGAPEEKPQVNVDITPVKTASDVCKELANKTKYPWYKLTLYEVIANGALIRPIHYSEKVLEIVVRWTYWDEVDRKNNYLTLKPTTTLNDVYRTIQKAPVLTPTMELKFADRKTKALRNFQLQLIGRGLVVLKKIEKKDKGFEELLKIDLSRMTAYIGCEPKRDRSSLRWAITLVDNDFKKRTRDSPYIGHIFGGLDFASQILWYSSILYSHYKDDILPSGDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIS9</accession>
    <name>A0A084WIS9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018179</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023945">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIS9"/>
    <dbReference type="STRING" id="74873.A0A084WIS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018179-RA">
        <property type="protein sequence ID" value="ASIC018179-PA"/>
        <property type="gene ID" value="ASIC018179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018179"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005116"/>
    <dbReference type="OMA" id="YHQFECE"/>
    <dbReference type="OrthoDB" id="6054366at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47111">
        <property type="entry name" value="BCDNA.LD29892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47111:SF1">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="163"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="63473" checksum="8144A5514E39E7DD" modified="2014-10-29" version="1">MLRPEVIKQLESPAMGLATSWAISRRSVPCRNLEEVRDAFKRKYWPFEKDKVAKNNEKAISLREQGNLAYKTTPKDADRAMEYYNKSICMAVEDSEELGIGYANRSAVYFNRKMYRECLENIRLAKEHHYPERLMNKLIEREERCLENIALSNENPEEAETGEKHCSLKSCLEMSDDGKGIRTSCDLSAGEKVLLEKPFLLVVEPELAYKRCDYCGKNNNFNLRPCTSCTAVMYCSENCQEQALQRYHQFECEIVDELKLLFRGPKANRLLHLSLRLFWHGVLLYLEDPETFPQRCENRAELVQYRNPFTLEPSDYFFYLYLKGSEKLASKERSTEQVDLTGICVTQFATVLIYYLAVEENTSLVQRFEGKEAGELLRKLLFALVYQASDLADHRPEETTCFYPFSRLIRHSCAPTAERFLHNFQTMVVLKRPVLMGQEITIAYDEKLTTDRTTKEKRLEKASSGYNIQECNCEGCKSDYPLLKDIEKDEALSKELETIRVEANEVYQRNKLAEFLDRYDNQYPKQELVEAWNMYREFILKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJD9</accession>
    <name>A0A084WJD9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018602</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJD9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018602-RA">
        <property type="protein sequence ID" value="ASIC018602-PA"/>
        <property type="gene ID" value="ASIC018602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018602"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8040" checksum="FE872FC9DC2664A3" modified="2014-10-29" version="1">MENTLLHRNRNSNYDIQSQSEIARCSSLKGEKGAKEVPDTAILDISSGDNCFHIHPSACTVDPLPLKTDGSVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJN1</accession>
    <name>A0A084WJN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005761-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJN1"/>
    <dbReference type="STRING" id="74873.A0A084WJN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018454-RA">
        <property type="protein sequence ID" value="ASIC018454-PA"/>
        <property type="gene ID" value="ASIC018454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018454"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007266"/>
    <dbReference type="OMA" id="WHGFTFY"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="2">
        <location>
            <begin position="189"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="577" mass="65140" checksum="E612434D9B505E61" modified="2014-10-29" version="1">MIEYTERFFRGLDLWSLAVDQAFLNVSHAEAVNGAGTDYYLYTLSEECDKCPFTQLQRIPADKRHTVIKVDASRRFALRLHDRDVGRYSYPNESYFCQLSGLQLGEFGVYDLRLNDGGAPCVLETAKEPVNIYLPFLTILLLAVVVGGLVRLARYGLRRSRLPAASVEPPVEETDKPEQETVTQAPNKRLQSLDTFRGIAIMLMIFVNSGGGGYWWIEHATWNGLHVADLVFPWFLFIMGVCVPISLRGQIARNVPRRTIVSNIAVRSLKLFVIGLCLNSMNGPTVANLRIFGVLQRFGIAYFVVSIVHLFCHEDAVQSQNRILRANEDIFRLKKQWLVMGLLTVVYLGVILFVAEPGCPSGYFGPGGKHLMNAYPNCTGGITGYIDRAVLGIEHLYQRPTARLVYDAMPFDPEGPFGCLPTVLQVFLGLQCGCTILAYACHRKRMVRFGVWSVVLGLLAGVLCGFSKNDGWIPVNKNLWSLSYVLATGSLAYLLLLLCYYAVDVKRCWSGRPFVYAGMNAIVLYVGHTVFHKMLPWHWRIGTMNTHFMLTLEALWNTVLWNLIALYLFQRRIFYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK84</accession>
    <name>A0A084WK84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018952</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018952-RA">
        <property type="protein sequence ID" value="ASIC018952-PA"/>
        <property type="gene ID" value="ASIC018952"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018952"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018952-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11290" checksum="CD9EAFEE4B44DD43" modified="2014-10-29" version="1">MEWSERERDRLTAEQHNTTRTLPTGRLHQTPCTPLPSPIGSTAADADGFDTDADVGGREEGIGARLWLKSTPHSGRSQATFIDSYASMAHRNSPGIWQRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKB2</accession>
    <name>A0A084WKB2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00018690</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01024105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKB2"/>
    <dbReference type="STRING" id="74873.A0A084WKB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018690-RA">
        <property type="protein sequence ID" value="ASIC018690-PA"/>
        <property type="gene ID" value="ASIC018690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014429"/>
    <dbReference type="OMA" id="GLKFWLH"/>
    <dbReference type="OrthoDB" id="8958249at2759"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="21">
        <location>
            <begin position="62"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="20">
        <location>
            <begin position="285"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="19">
        <location>
            <begin position="581"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="807"/>
            <end position="811"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB50656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="857" mass="98582" checksum="7332C7400F3293A1" modified="2014-10-29" version="1">MGGAQANHSPLYIRVRFSAPERLMHRDSRPPAPQIHCRMLSGKTAIDGGLAPDHRSEARLRIDPKVLVFVETTYTQLGKSITELLVHNRIKYKVEVAGKSLPVLTNQDKGRYGVIVFENLDKYLNMDNWNRQLLDKYCRDYSVGIIGFVSPSEETLVGAQLRGFPLYVHTNLRLRDASLNPGSPVLRLTRAGDTAWGPLPGNDWAIFQHNHSGYEPLEWAQKNVMDYPTDGVAQPPLATVLQDHGQLDGIQRILFGSGLKFWLHRLLFLDSLSYLSHGQLSLNLERRILIDIDDIFVGEKGTRLKPDDVHALIATQNRIGEMVPGFRFNLGFSGKYFHHGTHEENLGDDMLLRNVGQFNWFSHMWNHQQPHLYDNVTQLMNDMMLNKDFAKEHGIPTDSGYSVSPHHSGVYPAHEVLYTAWKKVWNIKVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTICIDSYPGGRDKLDESIRGGELFQTIVYNPINIFMTHMSNYGNDRLALYTFESVIKFLRCWTNLNLTSVPPLKLGELYFRLHPEERDPIWGNPADDPRHAKIWAGNKRRTTLPKLLGLGPQKTGSTAFYTFLSMHPAVASNLPNSDTFEEIQFFNGNNYYRGLDWYLNFFPLQPNDTDDKFMFEKSATYFDGELVPRRAHALLPKAQLVTILISPAKRAYSWYQHIKAHGDPIANNYSFYQVITASEGEPKALRDLRNRCLNPGKYAQHLERWLACYPQQQLYIIDGEQLKSNPVTVMMDLQRFLKLPLFDYSQHLRFDNKKGFYCQVVSENRNKCLGKSKGRQYPPMDDRSAKMLQKYYRIHNQALVKLLKKLGSRPIPQWLKEDLSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL27</accession>
    <name>A0A084WL27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Laccase-2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018958</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL27"/>
    <dbReference type="STRING" id="74873.A0A084WL27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018958-RA">
        <property type="protein sequence ID" value="ASIC018958-PA"/>
        <property type="gene ID" value="ASIC018958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018958"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018052"/>
    <dbReference type="OMA" id="SHIVIRI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000073">
        <property type="entry name" value="Laccase 2, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000031">
        <property type="entry name" value="Laccase-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF232">
        <property type="entry name" value="STRAW, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760024" evidence="5">
        <location>
            <begin position="27"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="198"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="324"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="581"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="754" mass="83908" checksum="D7C9BB874583CC58" modified="2014-10-29" version="1">MAIDWRNRVNIASLGMLLLVAVAAEAVRVSQHTSRRFKDESLSRDQSPASSWWSSHLTEPPSKNFYQATHGLLQTHPSVPGLKPASPSALPLSSAGTRSPTVGAPLSSGSLNSGFPSIANPNPRSPFRHLDFSTSATAELRRNPSLSAPDECARACREGEPPRICYYHFTVEYYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTVNRMIPGPSIQVCENDRVVIDVENHMEGMELTIHWHGIWQRGTQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTHFWHAHTGLQKLDGLYGSIVVRQPPSRDPNSHLYDFDLTTHIMLVSDWLHEDAAERYPGRLAVNTGQDPESLLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFASVCPAQVTIEGHALTVIATDGEPVHPVQVNTIISFSGERYDFVITADQPVGAYWIQLRGLGECGIKRAQQLGILRYARGPYQPASPPPTYDVGLPQGVVMNPLDAQCNVERDDAICVSQLKNAKEIDRALLQEKPDVKIFLPFRFYLYRPEELFQPNTYNRFLVAPTGDHVISLIDEISYLSAPAPLLSQYDDINPEQFCNGDNRPANCGANCMCTHKVDIPLNAIVEVVLVDEVQQPNLSHPFHLHGYAYNVIGIGRSPDSNVKKINLKHALDLDRRGLLHRQYNLPPLKDTIAVPNNGYVVLRFRADNPGFWLFHCHFLFHIVIGMNLILQVGTMADLPPVPPNFPTCGDHLPPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLD1</accession>
    <name>A0A084WLD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024222">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019074-RA">
        <property type="protein sequence ID" value="ASIC019074-PA"/>
        <property type="gene ID" value="ASIC019074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019074"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="15762" checksum="C544A1708A513EE6" modified="2014-10-29" version="1">MEMGLPAMHLAFKNATAHIGGPEGSWVDRDPVVFPRQATVNKPRSKAFGGKDTKRTTPHAGSAKPVNGVGTVGREQTRKQKSKTAFTALLMVAGSLLLLLQGGATMQNVPKTSVRKERMLDGPIRNEQRISPDARQLFSSPCTKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM89</accession>
    <name>A0A084WM89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019390</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019390-RA">
        <property type="protein sequence ID" value="ASIC019390-PA"/>
        <property type="gene ID" value="ASIC019390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="10557" checksum="7D452DA56259E2EE" modified="2014-10-29" version="1">MFERFDHSMLRRRLHRPKVIETWPELGKMCCVSLVGDEDTHAAYVDDIISEGHNSSKQFQTARSGQDMLRRTRRRPHRFQCGNENVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMW4</accession>
    <name>A0A084WMW4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP006803-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00019625</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMW4"/>
    <dbReference type="STRING" id="74873.A0A084WMW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019625-RA">
        <property type="protein sequence ID" value="ASIC019625-PA"/>
        <property type="gene ID" value="ASIC019625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019625"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015817"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018351"/>
    <dbReference type="OMA" id="VHIRMVE"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000054">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF65">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="7"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="823"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="874"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="918" mass="102032" checksum="6F7489D587FA0C96" modified="2014-10-29" version="1">MATDSRKIKVAVRVRPFNDQEKEKNPRNIIKVLDKSTLMFDPDEDEDEFFFHGVKQTHRDITKRVKKKLTMEYDDVFDNTATNADIHEACTKPLVQSVMNGYNCSVFVYGATGAGKTHTMLGNENCPGITFLTMKELFREIDALSDVRKFDIGISYLEVYNELVMNLLTKSGPLKLREDANGVVVSGLVLKQIHSANELLDLLALGNRNRTQHPTDANAESSRSHAIFQVHIRMVEKKTGQKRTVKLSMIDLAGSERAASTKGLGARFKEGANINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSLGGNCQTVMIANISPSSLTYDDTYNTLKYASRAKKIRTTVRQNIVPSNVPKEFLVKKVNEQAEEIERLKAKLAELEEHRKLNTLTNATPPAALDETLLNTWTSRIDSCYASLLQAVQHNYALKSKEKLLNMRVKLKEQAEQIARIVTLDGSQSSEDIAKIEASIDRCGKQLASQEIDQNRWLERLQQAQRNRNALRHEVLQSELSSVLKTYMTGKDAEIAAAKATLWKDHVLQIAFTYSQENRLWHNIMQLSGEVIQNNYLLLRHLDRLDNVVLDKLKRLVKLNQRQRGVTFFDDECQQDLRSETNITDHSIDDIANLSDCSDDAVDFPPVVAGVKRTKINGESESETDHETSDPVSSKPSDAVERNVFKKPKTVSRGLSFKATSAAATRPTISRRTPTKTTGHGSVAKTAVATQRLKAPRLVVTNMMPAPAPAVASSSRKLGATSHTETGDDKSDTSDEQIGVGNIANSTFDIGSGKDDDSESLFSNVLVESNVDPHVLDKVLRRASMKGKMTLSVHKENRKKSPKRIGKSPRSINRSGSRANASATSVINRYRMMKGKEAAAVASSSTVPSTSSSSSTMGKATRFVNNNLENDSDRNRHNRLMGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMY8</accession>
    <name>A0A084WMY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019652</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024539">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019652-RA">
        <property type="protein sequence ID" value="ASIC019652-PA"/>
        <property type="gene ID" value="ASIC019652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019652"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011164"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="15315" checksum="9921EDBE0AFB4892" modified="2014-10-29" version="1">MNYYTNNRHCRADWHTGSHPKPGEDVLYSPSRKDKNPVLIRRPDVVHVKVCRVTTSGDEEQKWRINEPTKGREINFCQEPSTDRSFCGRNVSRECRKFETGNPKKKKSFNSRTSFAAQQFGCKSLKPLGANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNS2</accession>
    <name>A0A084WNS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003469-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020023</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB51866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNS2"/>
    <dbReference type="STRING" id="74873.A0A084WNS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020023-RA">
        <property type="protein sequence ID" value="ASIC020023-PA"/>
        <property type="gene ID" value="ASIC020023"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020023"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009707"/>
    <dbReference type="OMA" id="ALQWFNA"/>
    <dbReference type="OrthoDB" id="8119930at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF13">
        <property type="entry name" value="OSIRIS 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785261" evidence="2">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020023-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="268" mass="29359" checksum="3B8F1E0CF5DCB44C" modified="2014-10-29" version="1">MRSFAVFVVSLAILGCHVRGQSRSAADVAQDIYRSCLASEHGLKCAKVKALAWMASVAEQDEIAITDSMTVVRTGTEDPEAPVEVPADQQQQRAYGAVQLLNKIDSFLATHALKLTPPSVLRSEEARAYIPESLLQGGLAENLVIPLTEGNVAEGRGFVKKVMLPFLLGIKFKSTVLVPLALALIALKTWKAMTLGLLSLVLSGAMMIFKFAKPKIVNYEVVHYPPPHHVHHVDHHVDHHAPHVHWDAPPAWKKRSLDAHEQAYAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ28</accession>
    <name>A0A084WQ28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020521</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020521-RA">
        <property type="protein sequence ID" value="ASIC020521-PA"/>
        <property type="gene ID" value="ASIC020521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020521"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12502" checksum="1D2439D83492F2E3" modified="2014-10-29" version="1">MEENRDTLVQLSKRQWINEFIVHVNLILAAMGWPRVSWWVAGARVQALMSYDCTTTTVPMNKVQFISRRPRGRAIRTIWTHASAVSRAPGSGSGVIFEYGSGNGTMQQHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRP0</accession>
    <name>A0A084WRP0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006986-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021160-RA">
        <property type="protein sequence ID" value="ASIC021160-PA"/>
        <property type="gene ID" value="ASIC021160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021160"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018685"/>
    <dbReference type="OMA" id="QPQFAPF"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="14684" checksum="4B0E7FCB36687072" modified="2014-10-29" version="1">MALASAFPQPKPQPTPQFGAPTLIAPDFANRPLPLVRSARSVDPKAAQADNEQAGAAEVATGAEEKDDMDKAETFGFGYHHYYPSYGYGYGGYGGYGGYGYGGGYGGYGGYGYGGYGGYGGYGGYPYAYSYGAYPYGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSC3</accession>
    <name>A0A084WSC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002938-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026453">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525414">
        <property type="protein sequence ID" value="KFB53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021428-RA">
        <property type="protein sequence ID" value="ASIC021428-PA"/>
        <property type="gene ID" value="ASIC021428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021428"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005908"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785369" evidence="2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="277" mass="29865" checksum="41416BB7E85121AE" modified="2014-10-29" version="1">MKCVVLLYVLAALAILAPGSLCDDRRDEERALRRNRRTVQFLVNHFVQFLGLSGPSASAGTKKVEPKQDNVYAHPLTSILKASAGKFSGFSGGKQKPSPTSHREPTLQHDLPTWIEDRKTSNPYSEAFEADALEPTRVSLLSTTQEPEPETTTTTTTTTTTTEAPLTTTPESAPIAPTELPEELPEATTVLPEPTSSQPEQLDQSSTAPEAAEDQPQNESEGASSTEAPTAIDPAAVNTLSDTRIDVRNGFGEESFQPTPIPLXXXXXXXVVVFAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSP2</accession>
    <name>A0A084WSP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002557-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026652">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525416">
        <property type="protein sequence ID" value="KFB53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSP2"/>
    <dbReference type="STRING" id="74873.A0A084WSP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021556-RA">
        <property type="protein sequence ID" value="ASIC021556-PA"/>
        <property type="gene ID" value="ASIC021556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021556"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014569"/>
    <dbReference type="OMA" id="PAYIGRE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021556-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="23696" checksum="8E47FF485CEE7BD9" modified="2014-10-29" version="1">MSSCACPMTSPVGATLAALCGGPQYMLFMGLLEVFIRSQCDLEDPCGRTKAKTSRNVDYEYDFIVVGGGSGGSVIASRLSEIKSWKVLLIEAGPDEPTGAQIPSMFLNYLGSDIDWRYNTEPEQYGCLGSPEQRCYWPRGKVLAINAAPQLDQLPGGMTTPGVGEVPVGGNQTNPGDLTNNLNTTVPSNPAGGVGGAENATVPSNIGGVPNRLTNRINRLNNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSU1</accession>
    <name>A0A084WSU1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP006699-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00021607</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026716">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525418">
        <property type="protein sequence ID" value="KFB53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSU1"/>
    <dbReference type="STRING" id="74873.A0A084WSU1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021607-RA">
        <property type="protein sequence ID" value="ASIC021607-PA"/>
        <property type="gene ID" value="ASIC021607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021607"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024459"/>
    <dbReference type="OMA" id="INGPMEC"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18913">
        <property type="entry name" value="bHLH-O_hairy_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021607-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="25265" checksum="856117C81979A978" modified="2014-10-29" version="1">MVTGIGATAQQQVAGTPATTQIPPAEPVKRSSDNRRSNKPIMEKRRRARINNCLNELKTLILDAMKKDPARRSKLEKADILEMTVKHLENLQRQQSAMSQATDPSVMNKFKAGFNECAQEVGRFPEIEPVVKRRLMQHLSNCINGPMECHSVTSPQQFHHLHHQQQQQHSFNSTSSSSSSSSSSSGSNGGSPDSPLSLVMKKPYHDEDEDQEMKHDDDGKPWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTS7</accession>
    <name>A0A084WTS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002607-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021862</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTX3</accession>
    <name>A0A084WTX3_ANOSI</name>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="EMBL" id="KFB53667.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021914-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="84" mass="9469" checksum="69A948992E9821F5" modified="2014-10-29" version="1">MANNSSTTERLLDSPTESYSSKALTPVIRIEPRPNSSRHKRVRIFFPRGSRADRRKATTLLARSAPNPENHQVIPRRSANGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="17 18 19">Carboxypeptidase</fullName>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-09" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterization of eight carboxypeptidase genes cloned from Anopheles sinensis and their expression in relation to blood feeding.</title>
            <authorList>
                <person name="He Z."/>
                <person name="Zhi Z."/>
                <person name="Chen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AHC32035.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC018748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018748"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006638"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010849274" evidence="15">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="125"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AHC32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB50552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="421" mass="48116" checksum="DC580082165342F8" modified="2014-03-19" version="1">MKSLVALIACQLLLLALARAGSYHEFEVYNVRPETQEQLKELLKWRTMADVDFWDAPKLNRNARVMVARPERKIVEEFLERHDIEYDLVVEDVQEMLNKEHRRNEEHNRRIKRDSNSRSTVNFEHFWTLDEIYDYLDELALAYGSLVRVSQVGETHEGRPIKAITISTRGEIDQTRPIVFIDGGIHAREWAGVMSVMYMIHEFVEHSNQYAAQLDNADYVIIPVANPDGYVYTHAENRLWRKNRVQNNVLCYGVDLNRNFPYQWDRTTTECTNNFAGKEASSENETKTIIALMDRYKAAIRVYLAVHTYGELILWPWGYDFLHAPNEADLQRLGEQARDALVAAGGPTYEVGNSADILYTATGATDDYAYSLGVPFAYTLELTGGGSQGFDLPASELPRVTAQTFELFKVFGQHAGTLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA23</accession>
    <name>A0A084VA23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP003166-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00000267</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01001225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01001226">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523952">
        <property type="protein sequence ID" value="KFB34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA23"/>
    <dbReference type="STRING" id="74873.A0A084VA23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000267-RA">
        <property type="protein sequence ID" value="ASIC000267-PA"/>
        <property type="gene ID" value="ASIC000267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000267"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012179"/>
    <dbReference type="OrthoDB" id="535167at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="340"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000267-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="514" mass="58467" checksum="43293ED2B91F72B9" modified="2014-10-29" version="1">MACVVGNVAVAFGLGGHILFVNLKTSQKTYYLADSAPAGNGVACLTGHKLFPVLAFAERCVNPRLVLISYPANAVLSILEGDQMERSYIALCFSESELLVALTGVPDYSLEVYAWRSKELLCKKPTGIFSDQQRLVCSPSTTFATQLRSIVTVSVFQDLAKRIVAKKTAGTHGNLLLPKECLDYLTHCETLDQQSNCPAGMDGSLWQTLIKMRRIKIESEFRLKSCELMLSDAEAAIGAFQREITSKRNILAGLEQNLEQLQHEKFEDATNRTVQLVMKRGWIEIQQTGRESDFERCVLIHRSDVEDINAIIRRAGSKKLNAMVNAAMFRRKIIYQEWEHRALKLQLRDLRDQLATVEKCKITKEVQSWLKMKGMRRTEDLSQVALEKKIRNAIQNEEEMLQELKKSLEDIELRINTKRRENKALDQQTRTLNIDVTEQHLQRDTELEQTEQKATQDRMAAIVERARLVRLVQAQHTQILELGTMLELQRLKTYPTLTASTSVMTHNAHHLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC62</accession>
    <name>A0A084VC62_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524585">
        <property type="protein sequence ID" value="KFB35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002394-RA">
        <property type="protein sequence ID" value="ASIC002394-PA"/>
        <property type="gene ID" value="ASIC002394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002394"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783463" evidence="2">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10097" checksum="A559933CAED1B2BB" modified="2014-10-29" version="1">MKFAIVLLALFAVACIEARPHPAEENSAVAEASAESTEENDAAVKAEAKASAEVKIDQADIDELVKELENNPEGRRLKLGKVLGAIAKVAIGAVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCT1</accession>
    <name>A0A084VCT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBM39 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002680-RA">
        <property type="protein sequence ID" value="ASIC002680-PA"/>
        <property type="gene ID" value="ASIC002680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002680"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015293"/>
    <dbReference type="OMA" id="GHRIGKI"/>
    <dbReference type="OrthoDB" id="7721781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783248" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="2">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="274" mass="30705" checksum="9DDDA0BEE0174358" modified="2014-10-29" version="1">MKHHIVLVLALQLLHTSSGGLLDWFRGTDEQQAGHKVGQVFVEVLTPKGVRLWTHHNPDTVELGVELYVKFYGGQTEALECGLCKSTTEPIDGKFMLENPDLVARFGDVIEYIITTSNGTTTRRHPIRRVFVREELIKPIGRCVCRDRAPSALTEAQGRALSEVQLLERLILRALSNRSDSCEAISNWLVLRSEPRNERADLKEYVQLYLDLLNLRSKRTSPGFGGGWFPSSMVVKVEDHADGIAFQVKSVMEKLKILELLNLGGVLADFDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD80</accession>
    <name>A0A084VD80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002879-RA">
        <property type="protein sequence ID" value="ASIC002879-PA"/>
        <property type="gene ID" value="ASIC002879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002879"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011312"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783254" evidence="1">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="14961" checksum="5354E9B2A15D5457" modified="2014-10-29" version="1">MAPISLPFTFTVLGLLVVSFHLVSSLSTTLYGSSGSTYARHISGTSSCDVDRRTEPPERSDCVCEKRCDQRQVKFRCKIIAVEDVYAPKTGASSSRSLRWAEENSLKPISQRLIGDFGFLIAKHFLAVLCSAQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEM3</accession>
    <name>A0A084VEM3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003584</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003584-RA">
        <property type="protein sequence ID" value="ASIC003584-PA"/>
        <property type="gene ID" value="ASIC003584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003584"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003584-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10455" checksum="B561C4F377807316" modified="2014-10-29" version="1">MIDRSFDCTSVSGALGKVTIIRAETEWKMVENLFSICQKFNGKRKPPFGKEKRAPIDLGHATGNLEVRPETDDCNRRPDLAIRRTDDRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF56</accession>
    <name>A0A084VF56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007717-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF56"/>
    <dbReference type="STRING" id="74873.A0A084VF56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003797-RA">
        <property type="protein sequence ID" value="ASIC003797-PA"/>
        <property type="gene ID" value="ASIC003797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003797"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015086"/>
    <dbReference type="OMA" id="QSKAVHW"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11781">
        <property type="entry name" value="SH3_Sorbs_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11782">
        <property type="entry name" value="SH3_Sorbs_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11780">
        <property type="entry name" value="SH3_Sorbs_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="322"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="381" mass="43960" checksum="B05446AA2613070C" modified="2014-10-29" version="1">MAKMIYSAHVWKGVRFDSRVDPVFPSTESPRRYIESDVNIHYKTPIRFEYKEPIPDDELAYRQAEHMRRVYQEERRRKYINELEDMHSRRHTDNIPPSQKSPIPLNRYDDFAADLSPKPQHVLKQPKTIARALYNFQGQSIRELSFRKGDIIHLRRQIDKNWYEGEHNANVGLLPANYIEILNRDNVNVKPLPKKPVREGKARAKFNFTAQTGVELSLLKGELVTLTRRVDDNWFEGKIGSKKGIFPVSYVEILTDINGEESYDIEPIVHRPQSAHGVTSQPTHTLTTHYGASHTNGRVSPGILRETKTVQKTEVLHVDTSNEPISYRALYNYKPQNSDELELLEGDVVYVLEKCDDGWYVGTSARTGCFGTFPGNYVSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFH5</accession>
    <name>A0A084VFH5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008579-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003870-RA">
        <property type="protein sequence ID" value="ASIC003870-PA"/>
        <property type="gene ID" value="ASIC003870"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783426" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003870-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="233" mass="25709" checksum="BF4B17A73957A81B" modified="2014-10-29" version="1">MKLVIAIAVLCLCSSLSEAGYTTSTEVVQKLNQTEKMYKHLQENIINIVAWVKLNTAAKTNAFYQTISDNKEASLKQSLQLEDAFSYQLNNEVLSPDSPCLGHLRAIMENNMFMAGVGYTNCVNTVEAGLKEELEVDESELFDLSLLDVFRDENIIADPVKIIAKLNEKASEIRGISESFVTEINAAADGYATRLSALEKSYNSCVLSNESVLKQAFESSKIQLTQICMGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFK8</accession>
    <name>A0A084VFK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003909</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003909-RA">
        <property type="protein sequence ID" value="ASIC003909-PA"/>
        <property type="gene ID" value="ASIC003909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003909"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11075" checksum="49751EC6FC6FF5CB" modified="2014-10-29" version="1">MAATTTSVPAAYHRGHLARDSESVCVSALGTNTHARNLPIHHREQVFLVRCDDGSLLLGWCAAAQTQSEKENTAPGDIEKQSTLQNVGNGNTPSEASADQVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFU6</accession>
    <name>A0A084VFU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008320-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524794">
        <property type="protein sequence ID" value="KFB36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFU6"/>
    <dbReference type="STRING" id="74873.A0A084VFU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004005-RA">
        <property type="protein sequence ID" value="ASIC004005-PA"/>
        <property type="gene ID" value="ASIC004005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004005"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000236"/>
    <dbReference type="OMA" id="WRNTSEA"/>
    <dbReference type="OrthoDB" id="10006996at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="48469" checksum="B565486DC90C7110" modified="2014-10-29" version="1">MKSDRTRRQRKSFTPTSVWSYRKVTRYASGSYQCGALNSERETLSGKFYWRFENSEEVLEIEQQRFSNNGTSSQLHYTPTSEQDYGTLSCWGTNEIGTMAEPCIFHLIAAGLPTSVINCSWRNSTNSFEVTCHQGYDGGLKQSFVLEMISSRFPGHSINFTNAEESIFSVTSFDQIRQQLPATRQPDSLKLYVYSVNQKGHSPRIFIADLLIPAAPEEQEPMGDHKSNLLTPILIGLFLTIVLIIIVIIVRIYLKSKRLKQNINKEKRYTEESKNTLLLVDISKKDKPTKTTKWMNNVGSSIKTKTKIETIDDEQDPDLIPYPRLTDIHQEELIPMNSTGSSFTIKQQHHHQPQQQPHKQQQQQQQQSDIEQEKDKDRLYQQPKPIILPGTSYRDEEISVAEINLKGIEDFLMTNRVPESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGK2</accession>
    <name>A0A084VGK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">tRNA nucleotidyltransferasepolyA-polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004302</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524832">
        <property type="protein sequence ID" value="KFB37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004302-RA">
        <property type="protein sequence ID" value="ASIC004302-PA"/>
        <property type="gene ID" value="ASIC004302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004302"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014502896" evidence="3">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004302-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25165" checksum="86C79ED71766BF14" modified="2014-10-29" version="1">MVAVGTLLWIGLIPISVIGYCQQNQHSPELENFIYVSKNITAVVLQDLDPVAFGRINLNHGRCLKCTTQFRDTVLTIEIRCDPGEAKYVETVDWRASEMEVDLFLIKMGKTIVGFDLLLCNLANQTSGVLAVHNPYAYEYRDPSYGVMKYDEECACDYLINITISYDIRKQRVSNSTGRINDPSTVNQAEDKTSGEGLPKQYKIIVAGLMLIIILMLCIACSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGS4</accession>
    <name>A0A084VGS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011276-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013073">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524837">
        <property type="protein sequence ID" value="KFB37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGS4"/>
    <dbReference type="STRING" id="74873.A0A084VGS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004376-RA">
        <property type="protein sequence ID" value="ASIC004376-PA"/>
        <property type="gene ID" value="ASIC004376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004376"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004895"/>
    <dbReference type="OMA" id="LRQEPCK"/>
    <dbReference type="OrthoDB" id="7743108at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25028" checksum="BFD0C28274BD6400" modified="2014-10-29" version="1">MLLPPTSSFNGSVTSCNEAPVNGSGPYWIQVSENSSLPTVPAPLRQEPCKSCKDAPENVSGVYLIQVSENSYPFEAFCEQNSFGGGWLVFQYRFDGSLDFYRNWTEYKQGFGNINKEFWIGLERLYQLTSQGRYELLVELKAFNGSYRYAQYDEFQIGSESEQYPLKKLGTYSGTAEDALNRQKASCPSCHGPAGPRLGLGSEKTEPNSNRQQDGSINVTTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH20</accession>
    <name>A0A084VH20_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004484</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC004484-RA">
        <property type="protein sequence ID" value="ASIC004484-PA"/>
        <property type="gene ID" value="ASIC004484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004484"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000187"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9914" checksum="3E0143CAA4A4D5F5" modified="2014-10-29" version="1">MGDERSDVPETVESVEFLVEDESRYCEWPIAGPRDPPPIGPGQTDQILSSYYYADSPCDMVQNPPEVSIGDSLYSDPFXXXXXXXICCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH25</accession>
    <name>A0A084VH25_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004490-RA">
        <property type="protein sequence ID" value="ASIC004490-PA"/>
        <property type="gene ID" value="ASIC004490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004490"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004490-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7496" checksum="EECE341CA9C7A368" modified="2014-10-29" version="1">MNKRQKPSVNLKPEKQTAGNQPSCIKPPDASANQPQNLQPRRTFKRKAEDVECAVCLRMKYELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH69</accession>
    <name>A0A084VH69_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00004531</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH69"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004531-RA">
        <property type="protein sequence ID" value="ASIC004531-PA"/>
        <property type="gene ID" value="ASIC004531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004531"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011338"/>
    <dbReference type="OMA" id="NSSACYC"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF18">
        <property type="entry name" value="PROTEIN TWEETY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="287" mass="31884" checksum="AF5F226E7220FB46" modified="2014-10-29" version="1">MLSLGQPEGQDSDGPDFNLTLRAFYGPNSLGILASIPAALLIISLVFLLLYLLTRCCDRKPRKPKSHGCQKCTLIFFAIICCAAIGLGLYGNDDLHNGVLQIFGSGRKIEQLILNVRNQTEMVKHNLKSKVVLSELEQIFEQPAHRPNATALYMLHDTVKMAKDNTTFAINALETIVYLTRPAYTDITLKSLLDTYEFYEELRWPITLGFLTFLLLLCIILMIGATRSSRCALIFFSVCGLLAVTVCWLLSGIYLASAVALGDFCMKPNDFICSHILIVPFTGTSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHE0</accession>
    <name>A0A084VHE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004682</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004682-RA">
        <property type="protein sequence ID" value="ASIC004682-PA"/>
        <property type="gene ID" value="ASIC004682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004682"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004682-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12011" checksum="FD6FC69EC6E82A85" modified="2014-10-29" version="1">MVGGISASNIKRSINIQAKRSHHLLPAIGSEVEGNGREKSFPGNWLHLKCTFPVHDPLKLTFTHWEGAGGVCEELTSYNPGRDQCNVNQHRSKRCTKDIGFTGSLPKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHR1</accession>
    <name>A0A084VHR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="29">AGAP002739-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">ZHAS_00004740</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="29 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524845">
        <property type="protein sequence ID" value="KFB37505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VHR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004740-RA">
        <property type="protein sequence ID" value="ASIC004740-PA"/>
        <property type="gene ID" value="ASIC004740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004740"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012153"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015932"/>
    <dbReference type="OMA" id="CPPDMWV"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000368">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000649">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000032">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000201">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000048">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
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        </source>
    </evidence>
    <sequence length="3367" mass="368260" checksum="084C161B9CD8D7F4" modified="2014-10-29" version="1">MYTFPKCWTLLLIVAVTGIAAELRGLHCYKYFNVKHSWVKSSTLCKRYGSELVTVDSYDENNSTFQIATSSEYRTRNNVKYWLGFASLDDLRTNTLESTSRGLFSQYSGFWAINEPNPLAGECVAANLGATEQSWELRSCETLLPFMCKARACPQNSFHCSNGACVNQAYKCDGNDDCGDGSDELDCSANCNIYMASGGDVIESPNFPQKYPSLKSCKWTLEGPQGSNIILQFQEFDTEKNFDTVQILVGSRTEDSAVSLATLSGKSDVPNRTFITASNFMVIKFTSDGSVEKKGFRATWKTEPQTCGGVLQASKQEQYLKSPGFPQAYPGGIECLYIIAARKGYTISLDIQDLDLTADSDYLLIRDGESANDKPIAKLTGTIDTKPNRVIISTGNKLYLYFSTSLAQPAKGFNIRYVEGCTAVVNAPNGTVSSPAYNLAMYPNNQECYFVIKNPSGKPLSMRFVDFDVHSSDLVQVFDGPSTSGVRLHAGNGFTDSNAPKITLTASSGKMLLKFITDALYNGKGWSAEFSADCPELKPGIGAIASSRDTAFGTVINFTCPVGQEFATGKHRITTVCQNGGNWSVSYIPDCQEVYCGPVPQIDNGFSFKTTNVTYRGIATYQCYAGFAFGSGLATETISCLADGTWERQPACMASQCPPLPEVAHANVTVLNGGGRSYGTIINYECIPGYVRTGRPILICMSNGQWSSPVPSCSRKQCFKVPDVPNGYVVDKTREYYYGDEARVQCYKGYRLIGSHTVKCNEHQDFSNVPVCEDIDECQTSQCDATSTECMNAAGSFHCKCKTGYTSSMECRPVVDLGLSNGGIADDSITVSSTASGFEKGMIRLNSVGWCGDGKERGSNWVIIDMKAPTVVRGFRTMSVQRMDGTLAFTSAIRLEYSDDISDVFKDYANPDGTAVEFRILEPTLSILNLPMPIEARYIKFKIQDFVVAPCMKLEVMGCTRLDCLDINECAKDNGGCNQKCVNSPGSYKCACNFGYELFRQNGTEGFSIERHETGEKDGDIYQRNKTCVRRMCPALSDPENGKLLTSEIQHHFGDVVKFHCNFGYVLSGSSSLSCMSNGNWNASMPKCQSAKCVSLPDDEKEGPFVKRGDQNEILQPECKTIKPIGISSGIIPDSAINATSERPNYEAKNVRLNSVTGWCGKQETFTYVSVDLGKVYRVKALLVKGVVTNDIVGRPTEIRFFYKQSEKEDYVVYFPNFNLTKRDPGNYGELAMITLPKYVQARFVILGIVSYMDNPCLKFELMGCEEPSTMEPLLGYDYGYSPCVDNEPPVFQNCPQQPILVKRGPNGEVLPLNFTEPTALDNSGSIARLEVKPPHFKTTSYVLDNTVVKYIAYDYDGNVAICEINITVPDITPPLLDCPQSFVIELGEKQQNYYVNFNDTIKRVKTSDASGDVRVEYIPEAASIPLGGFRNVTVVATDKFNNKASCNFQVSVQPTQCVDWDLQAPGNGDIKCTTQESGGVECEATCNPGFRFTDADKKKVFNCKKGRFWKPSSVVPDCVSENTQRADYQVVATTTYRANGVVSELCLPQYQDQTAKHFASLSNVLSQRCSAVYVNMNVTILKSVPRLIEENVVQMDFILLIDPAVKQPQLYDLCGSTLNLIFDLSVPYASAAIEPLSNVKAIGNECPPLRALKSSISRGFTCGVGEVLNMDTNDVPRCLHCPAGTYAGENQTTCSPCPKGFYQHRERQGSCLKCPVGTYTKEDGSKAVQDCVPICGYGTYSPTGLVPCLECPRNSFSAMPPMGGFRDCQACPSGTFTYQPAAQSDTDCRRKCPAGTYSFTGLAPCAPCPKNYFQKSEGATTCNECPSGRRTDTVGSLTADDCKPVTCNENSCQHGGLCVPLGHDIHCFCPAGFSGTRCEIDIDECASQPCYNGGICKDLPQGYQCQCAPGYSGINCQEAKSDCDSNPCPARAMCKDEPGFGNYTCMCRSGYTGDNCDVTIDPCTAGENPCGNGATCHALQQGRFRCECTAGWEGHLCNINTDDCAEKPCLLGANCTDLVNDFSCDCPPGFAGKRCQEKINLCLSEPCNHGMCVDRYFYHECICAPGWDGSACDVNIDECESDPCKNGGACTDLINDYQCTCAEGYTGKNCQHTIDDCESAPCQNGATCVDQLDGVTCLCRPGFVGVQCETDRNECLSDPCNPIGTEKCLDKENAFECVCRQGFDGKLCDNDIDDCEYAPCQNGGTCIDRVGGFECKCPSGWTGERCNVQVTACDVERPCKNDAQCIDLFEDFFCVCPSGTDGKKCETAPDRCIGQPCMHEGQCKDYGSGLNCSCSMDFTGVGCQYEFDACEAGTCQNGATCVDRGSGYQCICPPGYTGKNCETDQVDCKDNSCPPGAVCIDLNNDFYCQCPFNLTGDDCRKSVQIDYDLYFTDPNHSSASQVVPFYTTASDSMTLAMWVQFAQKDETGTFITLYSASSPNVIGKRRTMLQAHSSGVQVSFFEDLQDVFLPFKEYSTINDGQWHHIAVVWNGKTGQLMLITEGFIASKAEYGINRVLPNYCWPVLGVPLMDGNRKEAYSDLGFQGKLTKVQIWSRALDVTNEIQKQVRDCRSEPVLYKNLILNWSGYEQTLGGVQRSVPSTCGQKKCKPGYGGSNCQQLQVDREPPVVEYCPSDLWIVAKNGSTAVTWEEPRFTDNIGLSKVVERNGHRSGETLLWGIYDVMYLAYDAAGNTASCNFKVTIVSDFCPALADPLGGAQSCKDWGAGGQFKVCEITCNPGMKFSQVVPKFYTCGSEGFWRPTAHPTVPLVYPACSPTKPAQRLIRIQMQFPSDVLCNEAGQGVLRQRIKNAINALNRDWNLCSYSMEGSRECRNVDIDVRCDRNRHPNGIVKRQTVLQISPESAYAINATIPIKSEIASNSNGQRLNTVNLLEKLILEDNQFAVQDILPNTFGDASSLNLVTEYACPQGQVVVEPDCVPCAVGTFYNVSSKTCLPCPEGSYQPEIGQLKCKSCPKIAGRVGVTALVGARSAVECKERCAAPNEGSFSCEICGLGQTTRTAEATSKSECRDECSSGMQLGLEGKCEPCPRGTYRKQGVHPSCLSCPNGRTTAKLGSSNVEECSLPICSPGTYLNGTLNVCVECRKGFYQSEFQQTSCIPCPPNHTTRSTAANNKNECINPCEDVSDGSPRCDPNAFCILIPETSDFKCECKPGFNGTGMECSDMCNGFCENSGHCVKDAKGLPSCRCKGSFTGTKCTERSEFAYIAGGVAATVIFIILIVLLIWMICARANRKRDPKKIISPAADQTGSQVNFYYGAHTPYAESIAPSHHSTYAHYYDDEEDGWEMPNFYNETYLKDDQFIGVQGPNGKLNSLARSNASLYGTKDDLYDRLKRHAYTGKKDKSDTDSEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHS6</accession>
    <name>A0A084VHS6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00004774</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01013224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHS6"/>
    <dbReference type="STRING" id="74873.A0A084VHS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004774-RA">
        <property type="protein sequence ID" value="ASIC004774-PA"/>
        <property type="gene ID" value="ASIC004774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004774"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019240"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="245"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="553" mass="62493" checksum="8BB1A1104431CB80" modified="2014-10-29" version="1">METTESKLNFHELELDERILKDIARLGWLEPTLVQEKAIPFLLEGKDVLIRARTGSGKTAAFAVPIIQNLLGRKGEDAVRETSVIVMAPSQDLCHQITKAFQELTFSCSTLVRVVDLSSKEDQSTYRHMLAEHPDIVVSTPAKLRYVLSEGVLNVRESLRAVIIDEADLMFSFGFEEDLREVLKNFPPVHQSVLCSATLDEDLITLKKMVLHNPVILKLQEPNVAIGSQLTHYQVEAGEEVDKAAILFILLKLKLIQGKCIIFVKSVERCYRLKLFLEQFNIRACILNSELPIKIRCHAVSQFNQGLYNTIITSDEMVAVNPAVVNKKHTKKTSTAKNLLQSTKAESGVSRGIDFQCVSCVVNFDFPPDVNSYIHRAGRTARGNNTGSVLSFVAADEVNQKVEVESFIQGLVGDETFALKRFQFNFADVEAFRYRALDAWRAITKLSIREARVKELKTEILNSEKLTSFFEENPRDLQALRHDRSLHTVHIQEHLADVPEYLVPPALKAMIPSKKANRNKRFSELKSNAQKRKAKAENPLLMDGLDYHKKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHU6</accession>
    <name>A0A084VHU6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00004771</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHU6"/>
    <dbReference type="STRING" id="74873.A0A084VHU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004771-RA">
        <property type="protein sequence ID" value="ASIC004771-PA"/>
        <property type="gene ID" value="ASIC004771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015816"/>
    <dbReference type="OMA" id="HHTIKEL"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19763" checksum="271280EA0F4CDCB5" modified="2014-10-29" version="1">MGTYKPIDISKEDFRKYLESTGVLDALTQAFIKCNAQRPKNAIEFVKQQLGDPLQETDVEILRHELRNARIEIEQLKKELSSSKPNTSSDEKLASSLDTTGDSETTPQKDTAVVQSSGESNVDTSTTASSEEPGAAQAAPVGTKEQGKNGEGTKTDAPTDEVQNVPLVEKPEEPEKQGNDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJG2</accession>
    <name>A0A084VJG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000986-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005382</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJG2"/>
    <dbReference type="STRING" id="74873.A0A084VJG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005382-RA">
        <property type="protein sequence ID" value="ASIC005382-PA"/>
        <property type="gene ID" value="ASIC005382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005382"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018236"/>
    <dbReference type="OMA" id="CNYHWAV"/>
    <dbReference type="OrthoDB" id="6358068at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF107">
        <property type="entry name" value="LD20793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783577" evidence="6">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="161"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="25191" checksum="55078A4CFAA15FD5" modified="2014-10-29" version="1">MKQFGALLATTIVGLALVAQVSGAAAPSCPEPYGEQAYLHPDHCDQFFLCTNGTLTLETCENGLLFDGKGAVHNHCNYNWAVECGARKFATDQTPLSTPGCEYLFGIYPDAAECSTSYHKCAFGEVHQELCEPGLVYDHRIHGCNWPDQLLDQCNPEAVVGFKCPQSVPSGTVAARFWPYPRFAVPNDCHRLITCVDGHPRLITCGEGKVFNEESLTCENPEDVPHACRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK91</accession>
    <name>A0A084VK91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005749</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524946">
        <property type="protein sequence ID" value="KFB38385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005749-RA">
        <property type="protein sequence ID" value="ASIC005749-PA"/>
        <property type="gene ID" value="ASIC005749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005749"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6305" checksum="FFC76F893B110FBE" modified="2014-10-29" version="1">MHCGPSILKVCPTLVRPDRTDCGFTIGFPLGHCCYGLLLFCGAKEKAGRSTTHQTRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKJ5</accession>
    <name>A0A084VKJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014226">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005894-RA">
        <property type="protein sequence ID" value="ASIC005894-PA"/>
        <property type="gene ID" value="ASIC005894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005894"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="183" mass="20540" checksum="C77503654425791F" modified="2014-10-29" version="1">MEREWCVGLVAFHPSRELIAGTDAIDALQLSLVDLPELGGVLHQQELRRAVSSVALRADIDCFVCSDPHLLTQKACKEAHIQKRTNDRECKDFDEAISKSGPNKTNAMIRIELKRRLCQKDEIATYRYVQPFSGASDSFSTAVPSLIPSRRRDGDLKPRKTNRNRTGWCSQGRTRTGLFSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKX6</accession>
    <name>A0A084VKX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00005999</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKX6"/>
    <dbReference type="STRING" id="74873.A0A084VKX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005999-RA">
        <property type="protein sequence ID" value="ASIC005999-PA"/>
        <property type="gene ID" value="ASIC005999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005999"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011307"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023622"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000024">
        <property type="entry name" value="High affinity cationic amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF95">
        <property type="entry name" value="LD37241P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="821"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="61"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB38620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122143" checksum="CAE715873FF1B694" modified="2014-10-29" version="1">MADEEDPKEYRWETGYEKTWEAIKEDDDGLIEGSVSDIIQKAKRKRQAMKRGFSKLGMMRHLYILLDCSEAMTVPDLKPTRFMCSLKLLELFIEEFFDQNPISQLGVVAMKAKRAEKISELSGTSRKHVKAVHALNNGVQLVGEPSLQNGLELALKTLRLVPSHASREVLVVMGSLTTCDPTDIHLTIETLKAEGIRCSVVSLSAEIRICKYLCTETGGTYSAVLDDAHYKDQLLQHIDPPQAGNQQEFSLIKMGFPHGKTESGKEPPLTMCMCHIDSADEPAKLTSGGYHCPQCYSKYCELPVECSACGLTLASAPHLARSYHHLFPVPHFNELTLEQVQVQEPRDPPVTNCYACQKTLASGTDKMVYECGSCHQVFCIDCDIFIHETLHSCVGCTTIPASAHNLQARKPVPPPHSYGRAAHCSTEKVRLELNNEAHTLINVTGCHERSAVPERYGIPSHEFKVAPLRKSQSAGTAVLPKGVDFGDANTTIPVRSMFSSRTCPIRRFWTAMTRKKQNEDDGSESKLARVLTLLDLTGLGVGSTLGLGVYVLAGAVAREQAGPAVVVSFMVAAIASAIAALCYAEFAARVPKAGSAYVYSYVSIGEFTAFTIGWNLILEYVIGTSSVARGLSGYIDSLADNKMSKAMREAMPIDVDFLSEYPDFFSFVIVLVLAALLAYGVKESTLMNNIFTGVNLIVIGIVLVAGGINCDPDNWSIDPKDIPPGVNGGAGGFAPFGFAGIMAGAAKCFYGFVGFDCIATTGEEAQNPERNIPLAIVISLIIIFLAYFGISTVLTMALPYYLQDPEAPFPHLFETLEWHAIKWIVSIGAIFALCTSLLGAMFPLPRVLYAMSSDGIIYKKLQTVHPKTQTPVLATILSGLLAAIMAALFNLQQLIDMMSIGTLLAYTIVAVSVLVLRYQTEELLESSEWSVTIPQVVRQLFNGERLQDPTKLSSAIVKVSVCVFAVFVCGACGILVPAEDYINGDYPGVIAGLAVLIAFMVGLFVVISLQPTDKIKLTFKVPLVPLLPLISVFFNLYLMFQLDSGTWIRFAVWIAVGYFIYFSYGIRHSIEGERLLTNAELANAKATNGIDNTGYDLSSDADGVQKSNSPPTYTITNEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLR4</accession>
    <name>A0A084VLR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000449-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLR4"/>
    <dbReference type="STRING" id="74873.A0A084VLR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006228-RA">
        <property type="protein sequence ID" value="ASIC006228-PA"/>
        <property type="gene ID" value="ASIC006228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006228"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010130"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1008" mass="106823" checksum="396020916CBFCCBC" modified="2014-10-29" version="1">MDVGSMSLGSTHSLATYVTRSSTPTVGTAPPSASTAAAAAAAAAAAAAAVAASKVYIDINPFGNNNGSTSASSTNHGPSVPALSSEFEFGAEKELSVGKALQLNACGMNNNIGGGSSNNNHYGGGGGGGGGGGVGLLKDKFSGAGIGASTVKLSSNQSVSKSASSSDGYGFYYNNQPPSLTCSPTENQSMAATLGNCNSGNNGGSSSVVVGGVGGGGGGVGGGGLLLSDDEDMSERSKKENTGASRWMERNYCHLSVSHYPSGPSKSKSASGGAVAGQQQQQQQKRGGSTSVYKPVNCYNMVLQSPLEDESDMEDRLKYFNYQHEMQTYNSTRKDKHGYPSAGSGDMHYAHKSIGGGEGDEIIVLGSNANEHENALLVGKQQQQQECDSSESHPNKMNLLHLNQKLEHVPHVGLSVASPSTDNELMLNAEFTDKQMVQFSEPDNKSTAGSNIMQYDGSPRRFGLNLCDESDYYLASSVKINLTSPSLLTLPRPGFPQRVVPATTSTSAATTLTAPNKTSMSTVPTPSSKLSCSPSLLEQVNSSLNKTMLFEVSKNGRTSDGEGEIYASGDISKANLNRMDKQLHSYEAQQPCDQGKPLLPEMDMMSEKGQLNAQAQAQADKELTMGGSSNFPPMTNSSTFDYLYEFSETRKVLEEFFKCPSTEDVEKFSDYNDSGDDDDAESLDVQYDYPVELERSKAIETTYIGNVNGSGKRDRNRSPKSPVLAGDGMTLEQEEDDDDEEQTADVEDEEEDDGKGKGLTKYNFKLTTNKARLIADYGGASMLRKKKSSDGYSLKGISNVGLAVVDDGDRYCSTDYDSRREDDRQGSLQTSNDARNDYAIRSSSYDAINDPGGYDVHPIISNGSDKDPLHYATVNGDGVDGRKVFARKYSKNFNYSPDTTDYDSNCGDYDSEISPQYGSDFGLITSGGATMCEDLNNGVISAASGAGQAPGDSLNCLFTSSAGNYPRYYAAMPVLEDGLSSGHVSDSDTNNHNANGTGSVMPPDLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM85</accession>
    <name>A0A084VM85_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="13">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00006403</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01014582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VM85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006403-RA">
        <property type="protein sequence ID" value="ASIC006403-PA"/>
        <property type="gene ID" value="ASIC006403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006403"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006199"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010042"/>
    <dbReference type="OMA" id="DQSAADM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000212">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="945"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="989"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1066"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1089"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1172"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="307"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="619"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="949"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="1264"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="873"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB39079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1504" mass="168801" checksum="5551897823190F46" modified="2014-10-29" version="1">MTFEEFCGGPFWDDELTWREENPDLTFCFQRIILQWTPCFFLYVFSTYEAYRIITSRYRDIPWNWFNLSRMGFTFALMVMSWVDLGVVVQNIDEPEVFDVQILVAIFNALAYILVLVLYFFYRKYGVRSTGTMFIFWFLKAFFGIIQMRTEAQLHDERGSGTGDFAEFQFVSFTIQYTFTCVVLLLELFPDREPRYSEFAKLKNPNPELKTSFFSRLFYLYFDSYAWRGFRKPLTDDDMYDLNPEDTSRELVPPFDKYWFESVEKGRRKQIKADKKAGKAGLVYKPNAATNGSVLPAMVKAYGGPFWFAGMLQFAISGLQFASPYLMQEIMAVIALDGPFWKGMIITLGLFLTSLLIALFNGQYFHRTFLVGFRIRTGLISAIYRKAMRISSFAKKDTTVGEIVNLMAVDAQRFFELTSYLHVLWSAPLIIALCIYLLYELLGAAVFAGLGVMVIMIPITGFIATRMRDLQVEQMEIKDERVKKMNEILSGIKVLKLYAWEPSFQNTVVTVRNEELDVLKRAAYYGAGTYFVWTMAPFLVTLASFAVFVMVDEENVLDPQTAFVALALFNILRFPLAMFPMMITFAMQAWVSIKRIDKFMNSEELDPNNVTHHKSDNALEVKDGTFSWGDDAPTLKNINLALRRGKLSAVVGGVGTGKSSLISALLGEMEKMKGSVNTDGTIAYVPQQAWIQNATLRDNILFGKPFDQAKYDRVIESCALKPDLAMLPGGDTTEIGEKGINLSGGQKQRVALARAVYADSEIYLFDDPLSAVDAHVGKHIFEKVIGPTGMLVGKSRLLVTHGISFLPFVEEIFVMKDGEVSESGSYQELLDQKGAFAEFLTQHIQELDDEDEDELKLIQEALKDGEGKKIVQRAMSTRSDRSGSSNGSIRKKRVSRAESRNSNKPRAVEAPAQLPSAATLIEKEESATGSVGYVVYLKYFKGIGLWLGFWSILFSVINQGASIYANIWLTDWSEDPEAATDNSVRDMYLGVYGGLGGAQSIALLIASIALALGCVRAAKELHNNLLESSLHMPMSFFDTTPLGRIMNRFSKDVDVVDNILPQSIRAWLLMFFNVVGVFVVIGISTPVFLAIVPAFLVIYYLIQKFYIATSRQLKRLESVTRSPIYSHFGESITGQSTIRAYNQQDRFMNESEQRVDYNQLTSYPSIIANRWLAVRLEVIGAFVVFFAALFAMVARDSIGQATVGLSISYALQISATLSFLVRMTAEVETNIVAIERLEEYTVLPREADWMKGTVDKAWPAEGKVEFKDYQIRYRDGLDLVIRGISLNVRGGEKIGIVGRTGAGKSSLTLGLFRIVEAAGGQIVIDGLDISSMGLHQLRSRLTIIPQDPVLFSGTLRANVDPFKTYSDDQVWKALELSHLKTFVKGLAAGLDHEVAENGENLSVGQRQLICLARAVLRKTKVLILDEATAAVDLETDDLIQKTIRTEFADCTILTIAHRLNTILDSDRVLVLDKGLVAECDSPQNLLANKESIFYGMAKNAGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMK5</accession>
    <name>A0A084VMK5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006539</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMK5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006539-RA">
        <property type="protein sequence ID" value="ASIC006539-PA"/>
        <property type="gene ID" value="ASIC006539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006539"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="17751" checksum="F55D7345EFE565CF" modified="2014-10-29" version="1">MSATFDSYEDGNEILALRGKWEPTPKVALGVETPPPTHRARGGWEEGQETRNPPAARFPRGFFSGAGGNGDEGTNASKAIGHVSFGAGWSPPGAIKRSHRVALGTRKAALSNDTRMNGTSGLFWTLLTTAMEIRKPPGRFWQWSALLPSNEKPDTAPAVQSIVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN82</accession>
    <name>A0A084VN82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008080-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006914</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014723">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VN82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006914-RA">
        <property type="protein sequence ID" value="ASIC006914-PA"/>
        <property type="gene ID" value="ASIC006914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006914"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013638"/>
    <dbReference type="OMA" id="HHETAIM"/>
    <dbReference type="OrthoDB" id="8193595at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1410" mass="154182" checksum="7AE212023C6B6818" modified="2014-10-29" version="1">MRIEFRSMVPWRPIPYHVPQQQLQQPQQQLISVASFDTTSKDELVHIAQHNAQILKQFNQPITQYNQHPPNGMKVQITTHQQAPGPGPVVHQHSSNVVHSQGPSYGHTPAVPKYMTTSLLHQTMYPQGPPHKQQQQLPPSKPFVKSDQITTLNMVHSSTPKITASISSHGAVGVKSAKFNGQFRDSVPTIVQKSTLKPHPVMNKLQSHMAITGFRQKQPVATSSNRLEHFINPNHLYGTYIQFGQSPAALQPSKTKFLSQLGSSGVPTFDSQTLKSFFNGPGYTPSVTQFKKLNYIQQQQQQQQQQLSQSNGKFPFPHFNQIPGDLPDFPKKYVTPSSAEKELTKSGTGIDSTPLFPHLPPSVLTPFFQQVQQQQQSTSYISGNKYNNFNLKTQHPAPPLSSQGSSGATSSSSSSSSSSSSKHSFSPAQFQQSHQSDRESLSNAFGSQIFGGASFNTYSTQQPLPIEHKPYEIVKFKEAPGKQLSAQFNEIHDEYSKNLVPPPPSTQQAFLPTVLNHLAESSPSKDPIEILNKYNINPHSPLQDANRFSYEFPRPTPISLSVSTTSTGGGSVSTTASTTTTTTQFPTATTLPRQQYYQHHYNQHQQHNKQQQSFLGEHQSFPNHHQQSPPILVTPLNDLGDGGWITREKYLTTEKPNVFKNLFRPAESEYKKHKLMHPAYTGLPPNRRPSATATTTPTTNSAAGSGSFSASTNSPWDQSTEEPIVTHSFFTIEDAIADPTLIPPKSKNKYKYTTDAEEENRQDDLQLEIVTIGPFFGSEESPIQQAVTTLAPPRGSGSKNGAGQQRRRRPKPPQSSTTTTEYTTVVEQESTESTTNTIDNRNRNRIRFRPRPITTVPPAASPVETEPASSVTTILPTPPPLPSFVSSEEFDGPVKKFRKKPHFTRNRFNVLNQREEDRLAQPEQTEPSLSTPAVTTTTSTTTTSTSSSTVGALGDQQASSVPAIGGGFRSRYRPAPQPKQPKDSQEDTADQVAPAVKVNSRLQNRPPTVASTVTTSTDAAAVFNSDESGVNFSDGQQQPQQPQQNRTRGDRPRFSIKEYRNKLNRTVASTATTISTVGSPAGGDLLETTAAPKLRFPTRNRFLLNARLNKTNVEANEIAPTGTGATTEKSTNETTTRSSFRPHGTRTYNRFTVKKPSTETPSVTSAANKPAANRGRTKTAYDQAVAANRTLAGTAFNTTASLINRRPPKITLRQRIQNYNRKKEMEQTVSATGAAGTAEDAGGVVPKMDDVADPSVDLNSVLSSISSSAEQSRPIDDLGTLGDASVGGFEAGSNRFGGAVAEESPVRASTTEGYRHHETAIMKISPKDTTSSTSNNADYDLNSASSDYSKRVVELTLSGTGTKDRGSFKSVNKGLLSRKVPGYFTLATEDPILPIEAFFPQVKKPSGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNI2</accession>
    <name>A0A084VNI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Putative nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00006868</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNI2"/>
    <dbReference type="STRING" id="74873.A0A084VNI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006868-RA">
        <property type="protein sequence ID" value="ASIC006868-PA"/>
        <property type="gene ID" value="ASIC006868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006868"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004967"/>
    <dbReference type="OMA" id="ACANDFT"/>
    <dbReference type="OrthoDB" id="7763049at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB39526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="324" mass="35534" checksum="8007D5A3D75A1172" modified="2014-10-29" version="1">MASVCFACANDFTPEAAKMRCCYCEEFFHETCTSLPDDIVASIKLRADVHWSCPGCTKALSNSRAKTLKDVGLQARFTKSIVTSLKDVIVEPLTAEVRSMLPTLIRGLPSPSLIDCDRPVPPQHHNTTPRPGRLSTESTNILAILTSQQVRAPGSFAAVVARSQKYARETISGSNTAPSPDLVATQDRRPPHFWLHIMGIAPIVTTAQLIASVQGRLDADDVIAFPLLGNGVDPASRHSLSFKVRIPTSCREKAFSPETWPLGVRVRDAARLTDLTFISTRNRLLTTHHCTLRYAHSFNTRNYDFNLRTCSPVADSTSCCSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNJ9</accession>
    <name>A0A084VNJ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S7, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00006887</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNJ9"/>
    <dbReference type="STRING" id="74873.A0A084VNJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006887-RA">
        <property type="protein sequence ID" value="ASIC006887-PA"/>
        <property type="gene ID" value="ASIC006887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006887"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005033"/>
    <dbReference type="OMA" id="DDTHRMA"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14870">
        <property type="entry name" value="uS7_Mitochondria_Mammalian"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000004">
        <property type="entry name" value="28S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="44"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="23732" checksum="09374F650A93B90B" modified="2014-10-29" version="1">MSQYGPHFIQPIIDKQKIDALQESGELSKISHVPIKAALSNQTSSVFYDPLVSQFTNYVMKQGNKQLARELVEKGFENIKRLQLERYHLAETEEEKAKIELNPRKLLHQAVENCRPLLQLTPIKRGGVRYQVPVPITEKRSYFVAMKWLLEAVREKERTVHFPEKMAWEILDAAANQGKVVKRKHELHRQCEANRAYAHYRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNR3</accession>
    <name>A0A084VNR3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP004202-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007047</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524991">
        <property type="protein sequence ID" value="KFB39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNR3"/>
    <dbReference type="STRING" id="74873.A0A084VNR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007047-RA">
        <property type="protein sequence ID" value="ASIC007047-PA"/>
        <property type="gene ID" value="ASIC007047"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007047"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011399"/>
    <dbReference type="OMA" id="GWGQNHF"/>
    <dbReference type="OrthoDB" id="192247at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16619">
        <property type="entry name" value="mRING-HC-C4C4_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="247"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="399"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007047-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="591" mass="67461" checksum="AE38DB960488BCC0" modified="2014-10-29" version="1">MASGSADQLVQLLGETIECPICLSSVDDPRLCPACSKLFCHGCIRQWLQKEECENGSSKCPNCKCNRTLEEFVSFRSGSAIDALKSIVDSKNDPSISSMSEGQTVCPERVQQGLRKLLLETEAVFIETEQRITQELDKQRALLKQSKDNLIKTINIMVQQEFREIHKQFHDKMEEANAWSDILTKNLDKHQIKLETAKYMVENEPSENLLHKRPELEQTCAKLVEDLKVISPNVKPYQFNSQLIPEPSTWKFSVRKYSAARSSNEVQYSDLVTDDIGSVWRLEVHPNGYDDAKNTSLSIFLQLYSGIEGQYHYSVELLGANRSHVYEDETYFELRKGWGQNHFIDLKALQDSYLLEDGLELRFSVRALNLIDKYEKMKKRASLLSAEVDLLKKETKPDCLNHVFTVRNVVEAAKNFGCLYSDVLADDLGGSWRLQIFPGGNGECKGNFLSIFLELHNGIPNKYEFTVALLHRSEKKVVKKTLEYCFQPALPFGWKTFLGREEFINNGYIQKDSLSIRLTITPPSALQKFNYLRQYHERALAAMPLARPESSVVEEPKPSSSHEPLEARLRKTSISFVKNLFTKSSSTEQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP92</accession>
    <name>A0A084VP92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009549-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007152</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP92"/>
    <dbReference type="STRING" id="74873.A0A084VP92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007152-RA">
        <property type="protein sequence ID" value="ASIC007152-PA"/>
        <property type="gene ID" value="ASIC007152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011347"/>
    <dbReference type="OMA" id="PQCTILH"/>
    <dbReference type="OrthoDB" id="6370328at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719:SF1">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="1">
        <location>
            <begin position="51"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="22188" checksum="DE8AEE8C7678732A" modified="2014-10-29" version="1">MENYGTPEAVAKSYRKYQPNTNINEKVALHIDRIRLEGSCRVPKPKLVPPPSDRNVIYFPQCTILHRCDDSTGCCMDTETCVPKATAEVELYFSVSRIGRNRQQAVAIKMTNHTECHCVRKGMEKAVPRSTANQPVVGFDWDAIGSAETDVPVCNCPEFYKPIFDSGSKCYCDCVSGAKECMRFKEGHEHFSLLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPQ7</accession>
    <name>A0A084VPQ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009463-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00007334</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPQ7"/>
    <dbReference type="STRING" id="74873.A0A084VPQ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007334-RA">
        <property type="protein sequence ID" value="ASIC007334-PA"/>
        <property type="gene ID" value="ASIC007334"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007334"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016342"/>
    <dbReference type="OMA" id="WMFFAIS"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF26">
        <property type="entry name" value="FI22810P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="80"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007334-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="665" mass="75606" checksum="082CCAAF05AC858E" modified="2014-10-29" version="1">MDILQQEVRGIALVNLSEAQSAPVYNQTTVPLNRKDSRNMDQAVIRNNTGNGNSFTSNHDIEGHAVRPFQNLPPREPVDIQFKDVSYVVDLGFRKGQKEILHKVNGKFPGSQLIAIMGPSGAGKSTLLDVLSGYRRTGVEGAVYVNGRIRNLNSFRRMTCYITQDDRLQTLLTVLENMRIAADLKLGPEVSRHEKESIIEDILTVLGLYEHQFTITKRLSGGQRKRLSIALELINNPTIMFLDEPTTGLDSFSCNQVVDLLKQLAKQGRTIICTIHQPSAKLFQEFDQVYVLSNGECMYQGCTNSLVPFLQSVEMPCPVYHNPADYVIELACGEYGDDRIQRMVMEMGNGESTDWFTDKRKLLKLEQLRKKHPLKKIIEQNEDLTATSQVHQLQVLIKRGIIKARRDATLTHLRIGVNIVIAAMLGFLFIDAGNEGSRVLDNYNLLFSILMHHMMATMMLTVLTFPTEMGVILKEHFNRWYTLKCYYLSVSIIDIPLSVFCCLIFTVIIYLMSGQPMEWFRFGMFFTISLLIVLIAQSIGLTIGAWFNVVNGTFLGPVLTIPMMMFAGFGVTLRDLPSYLKWGSHISYLRYGLEGYVNAIYGENRETLDCELKPYCHYRYPAKFLSEISMEGDQFWKDVYALCATLLLVRVACYFCLRWKVVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQE4</accession>
    <name>A0A084VQE4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00007561</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 13"/>
    <dbReference type="EMBL" id="ATLV01015192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VQE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007561-RA">
        <property type="protein sequence ID" value="ASIC007561-PA"/>
        <property type="gene ID" value="ASIC007561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007561"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000926"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1177"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1557"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1616"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1278"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1331"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB40188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1661" mass="187152" checksum="9FDD110B54461A85" modified="2014-10-29" version="1">MEWSWLRDWWRLAKFRRGAGRTERSRRRHGRGSSPVETDTAEASIGELSIDETREGDSNPGQSRERAKFFLPSRHNTSTDGASAGDGDDSALFDEDDDPTERALSDDEGAGLDLDLDDVLLYTCRLHGDHRNDLDPDVDDDGCCGCDECMMLNGDLDPTDGLDSDDSSTSGKQVVVAVCAMSKKSQSKPMKEILTRLQEFEYIRMVVIGEEIILNEPVDRWPLCDCLISFHSKGFPLEKAIQYAQLRQPYVINNLHMQFDIQDRRRVYAILEQEGIEIPRYAVLDRDSPDPKQHELVESEDHVEVNGVVFNKPFVEKPVSAEDHNIYIYYPTSAGGGSQRLFRKIGSRSSVYSPESRVRKTGSFIYEDFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSDGKEIRYPVILSNAEKLISRKVCLAFKQTVCGFDLLRANGKSFVCDVNGFSFVKNSNKYYDDCAKILGNMILRELAPQLHIPWSVPFQLDDPPIVPTTFGKMMELRCVTAVIRHGDRTPKQKMKVEVRHQKFFEIFEKYDGYRYGHIKLKRPKQLQEILDIARSLLAEIQTKAADSEIEEKQSKLEQLKSVLEMYGHFSGINRKVQMKYQPKGRPRGSSSDDGKHDCSTGILMVACSLSSADAPKEPSLVLILKWGGELTPAGRIQAEEMGRIFRCMYPGGQSRQPGAGEGPGTQGLGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANTNGLLDNDCDSSKYQNMAKSRLHELMQIDREFTSEDRAAINPGNAISINLAMNFVKNPVQCCAQVHSLIRSLMAVVAVKRDDPKTRDAVLYHGETWELMGRRWGKIEKDFCTKNKSYDISKIPDIYDCIKYDLQHNQHTLQFDLAEELYISAKYLADIVIPQEYGLTTHEKLTIGQGICTPLLKKIRADLQRNIEELGGDESVNRLNPRYSHGVSSPGRHVRTRLYFTSESHVHSLLTVLRHGGLLNVLTDEQWRRAMEYVSMVSELNYMSQIVIMLYEDPMKDPSSEERFHVELHFSPGVNCCVQKNLPPGPGFRPHSRNDSVTSKNASGDEDTTSRIDEENDTEEESSLSNNSSLHHTPSKTPTHGVEVTRQSISAFGSAGMPVKERRIKKIKPSSPIPIGSCHTVSGHEAMDLAKRLSEELAVQQQQQQQQQQLQQHQHQHQQQNPAPQHHGHHHTTSGSFGAVPKDIVRPLSPDSEPRARSFEHQPHHHTTTHYGHPHHHHHHHQHHGHGKAGQLRSKCKGDDGLDELYEKGTEVDDDASQEQAKEPPVRREEEPAVVSWKVNIASLCREQETEEEEEAEEEKGVERLELPARPTLYIGPVENSYSCDSISEFTPNLDDQELYVSSFSESDDEVDGGGDASGSEASRYYSALGQHDSHDDDEVTVPSLRRSLSYTFANDPVRHNGRQHQLQPSRTIGGRWTHHQLMTRSAVELLAHEEQECPCYSCWMALAMPRLRERRTTVRGRCYTTSAVGGQLDTLAVPTSHNRATKVDDSEGLLRVRFPVRTLARYASDPSLPLGPAWTGEGRSVSPEEEQETRHTHISEGMVFVSLTTPPPDEECEAPSYPPFYDVHERRQHLRGGRQLPDPDDDPHKHSQQAPAFADSGRRAIIIKLFFTTNTVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQR7</accession>
    <name>A0A084VQR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007287-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007799</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQR7"/>
    <dbReference type="STRING" id="74873.A0A084VQR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007799-RA">
        <property type="protein sequence ID" value="ASIC007799-PA"/>
        <property type="gene ID" value="ASIC007799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007799"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023239"/>
    <dbReference type="OMA" id="VAECATN"/>
    <dbReference type="OrthoDB" id="7718797at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054577">
        <property type="entry name" value="OBP47-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052295">
        <property type="entry name" value="Odorant-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066:SF3">
        <property type="entry name" value="IP02236P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21066">
        <property type="entry name" value="ODORANT-BINDING PROTEIN 59A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22651">
        <property type="entry name" value="OBP47_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783919" evidence="8">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="OBP47-like" evidence="9">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB40311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="20996" checksum="48EF9BA1EEC2919B" modified="2014-10-29" version="1">MAEVNLIVLVVFGIVLSSAFADNPCLKGPPVPKNAAECCVTPSLVEPSAFMACHSKWISQTKRQMAIEGIPRGCCVAECVMNSTKLYSNGKIDREALTKLYLDSAKPMPPEWKQIALDSIDACFKMADSMKDEIDAGAVLKPAFEGEQICHPISGTILACMGMTLFAKCPARLFTVNADCNKLKKYHSQCPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQY5</accession>
    <name>A0A084VQY5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007852</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQY5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007852-RA">
        <property type="protein sequence ID" value="ASIC007852-PA"/>
        <property type="gene ID" value="ASIC007852"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007852"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007852-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9451" checksum="D81760E5F31CDABC" modified="2014-10-29" version="1">MQAVAMNNFTQSKGTNYWLIQHLEQAHPERHSAPDGQMFQPVRNRCTLALHYTGDIMGAFARKNATGCKNRIGINHKPTDERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRI9</accession>
    <name>A0A084VRI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002725-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008087</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015690">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525027">
        <property type="protein sequence ID" value="KFB40583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VRI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008087-RA">
        <property type="protein sequence ID" value="ASIC008087-PA"/>
        <property type="gene ID" value="ASIC008087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008087"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020919"/>
    <dbReference type="OrthoDB" id="9994380at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="251" mass="29061" checksum="FB76CDEAF539B446" modified="2014-10-29" version="1">MVASITXXXXXXXHRAPANRSPPMHKPDRSRYSHESEVAHDVVERRPVDRHSGPEVYRDEGRYRASHEEPPKRGIKHADKYEERWRHGELAAPERYADTETSTSASGRRYHREEPKPQPAPVEPRKKSVEIRTSSPESTMHRISPKDRFQTAKEKFQQMERERHEQERLEQERLERERMLHSKRAVEHMPIQGRRGSLEPAAVSSHESNGWSSEEDELPPRGHGSRSNGSVGGVPTMGHGYRELTPEERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSK4</accession>
    <name>A0A084VSK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008499</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525055">
        <property type="protein sequence ID" value="KFB40948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008499-RA">
        <property type="protein sequence ID" value="ASIC008499-PA"/>
        <property type="gene ID" value="ASIC008499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008499"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16950" checksum="D49067E3F4AE7CE5" modified="2014-10-29" version="1">MRPDRRCILLSSRNEGTLSAKRCLAATQILSPTRPQRPEVGPVPGRIRRYLFIMYASQLRPSPAVFLETGFGHSKHEAPRRKGRKEKPAAPRRVALSVGKEEILGLVFSTTTFSALREQLFLRWPKRASEHDKGFVFKWNRAALRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSP2</accession>
    <name>A0A084VSP2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00008598</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01016120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSP2"/>
    <dbReference type="STRING" id="74873.A0A084VSP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008598-RA">
        <property type="protein sequence ID" value="ASIC008598-PA"/>
        <property type="gene ID" value="ASIC008598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008598"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012195"/>
    <dbReference type="OMA" id="GYQLLMS"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="27489" checksum="C4C0DF56E7CAD22E" modified="2014-10-29" version="1">MDELDTDDNVLRRPRTKTSFITCLVFNCLHPLCIFVPSILIIAVCWSRGLTHLFTWHVFLTGLGFHLLMAAGVALPNGGNSLARNSTHSTRRTIHWILQTVGGGCALIGTVLQYINRETKLKPHFVSTHSIVGLIAVVFVLLSLLNGVSALFGWKLRRFLRPSVSKLIHNATGVATFAMGMCAIALAYEYHIFKENFAHEVRILLVIVTVVTCVMSLFGVLKNIYNYLYETYLGCKSTEYILDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT14</accession>
    <name>A0A084VT14_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008566</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT14"/>
    <dbReference type="STRING" id="74873.A0A084VT14"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008566-RA">
        <property type="protein sequence ID" value="ASIC008566-PA"/>
        <property type="gene ID" value="ASIC008566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008566"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012996"/>
    <dbReference type="OMA" id="NCASTEK"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008566-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="40047" checksum="EF7B8442E74A6B21" modified="2014-10-29" version="1">MALGDFEMELLMTKLDYLQDKLQEVEQTMNTNMKEVKQHLEEKLIKHEKNINERIEMMETKFETNMRELKESLQKSVETSEHNTWTKLEDLKNQFISKMDSMQLQQTKTYQETTQIELKKLEDHLIAPLRSCRQVPGESGTYLFRLWKKAKPFDVFCEQNKFEGGWIVIQHRFDGSIDFYRNWTEYRNGFGNVDGEFWLGLEYVHQITKNRPHELLVEVKDFDGNYGYAKYDGFEIGSETESYALKKLGTYSGTAGDSMQDNKDEKFSTFDRDNDIWAASCAELYHGAWWYYYSNSANLNGRYLNSWNDDSAMKWYELKEDFRGLSYSRMMIRDIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVJ0</accession>
    <name>A0A084VVJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009557</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009557-RA">
        <property type="protein sequence ID" value="ASIC009557-PA"/>
        <property type="gene ID" value="ASIC009557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009557"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6557" checksum="532CC8A4551E7BD3" modified="2014-10-29" version="1">MWSFSKATAEHTLLGGSGGGGRAFDQPEIPAPGGGGGGVVGDAGVDWSRSSKWIGGIENHWNCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW50</accession>
    <name>A0A084VW50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009865</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15172" checksum="7FC31E45953C936A" modified="2014-10-29" version="1">MDSGHRGPVVLYSCLGGREAETPSPRSETGPREKPNGASPRSPEGKKMKHPGQHHASQELVRNAKKLATERKATVFDRWHDRKWPANVRSATARKTTPVPGRLGTLLPPRENVARTGRENRGLSLRGLAQMREAQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWV8</accession>
    <name>A0A084VWV8_ANOSI</name>
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            <fullName evidence="2">AGAP010118-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF5645 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010153</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="16105" checksum="73DCB84EA4D9C463" modified="2014-10-29" version="1">MNNVIDPLRPATPAEIDQLVNIYEQLLPESVQFVSILQNIVRIKTTLHGTALEQASHRFRKTIYIPNKANPIRFGTFLAIGMDEDIFVMVNTLEQPPSELEDAIRKTSYIKWHLKPMFVIGGDNGIRESLYKVVGEQVRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">ZHAS_00010174</name>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC010174"/>
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    <dbReference type="OrthoDB" id="7403399at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
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        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010174-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14084" checksum="90A91A7314913E7A" modified="2014-10-29" version="1">MSDPILSSTAKVARWFHTLQWTNQTQSLSRPESGFVSGDSRSERNQKSDVDMVDLLAKDHAGSNGVDLCDEYLLVEGTSNLWSKLSPRRRWPPPSAGVGPAAGHEGQPLVRLTTTAASLDSSSDTSDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">AGAP007100-PA-like protein</fullName>
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    </protein>
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        <name evidence="7" type="ORF">ZHAS_00011018</name>
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    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VZ46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011018-RA">
        <property type="protein sequence ID" value="ASIC011018-PA"/>
        <property type="gene ID" value="ASIC011018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011018"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017079"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020017"/>
    <dbReference type="OMA" id="PPYYDYD"/>
    <dbReference type="OrthoDB" id="6423981at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
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    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pan_app"/>
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        <property type="entry name" value="ZP_dom"/>
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    </dbReference>
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        <property type="entry name" value="CBM_14"/>
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        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784040" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="242"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="849"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="955"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="1581"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011018-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1710" mass="192334" checksum="0719EB8098CBDDFD" modified="2014-10-29" version="1">MRKKQKLLPGLSDFTVLVLLARLALVVAQTTCNNGQGRVLYERLPNQQLQGFDDDVVRDSAPPFRVLEKCQDLCLRDRTASTNLGRACTSFDFQPGSRIASFSGSVEYEESTCYLTREQAAPEGIGNLMLVPNSVHFTEVCITSSRPDRECPSRRYVFERHPRKKLKLPVSDIKEVTAANRSDCEDKCLNEFSFVCRSANYDSSLRSCSMSRFTRRTHPELLEDDPNSDYLENTCLNAERRCDGLIVYVKEENKRLGGPFEVEIFNNMTLEECQSLCLRAEKYFCRSIEFDDQTKQCILSEEDSVSQKDDLSISSSPTHHFYDLVCLDNQRGSEYPDNSVTSHLFSSGRRPDTAFQRYRNSRLGGEFHSEITGRSLSECLDECLRQTSFQCRSAVYSDRFRTCRLSRYNQRDGMRIIYDADYDYYENLMPHLVGGEPDTTNGRPDPTDWRPPYGGGGGDRDRDRVPDDRLPPGRYPPGERYPMGSRPDYGGDSYPGGYPPTDRYPGSTDRYPLGPGTDRYPTGGGDYDGRYPPVYDNRFPGDRYGPTDRYPDRDPDPMYPPGPGGPMRYPPPLPPPDSRYPSAPDTRYPMDRYPPPDSRYPPGPDSRYPPAPRYPPDSRYPSDSRYPPTQPDAGRYPPGPAPDARYPPPVHSGSRPDSRYPMMAPPATRYPPPQYMPHMYGSGMYPVVPSRVPPNRGYPPDPYPAPVRPVDSNRYPPPETRYPLEPIGAQGRYPPPTSPNVNPFYNYMKGRPSDYNYHMAGYEPQRGYVDDRYGGYYPSAGGRIPPPMPAFPERDRGYRRPGVGMAPEGGGYPFEIPYGPPSGTGYDNTLGGGDGFGGYGPQRPYETRCDNADVFKQVGSKRKMRKQYIRRVISAPSLGICQQECAGARDFMCRSFNYHDAAPYETEGNCEMSDRDSRDLEVPSAQMFENDNADYYERTPGRGGPQDECLDVGQVCNEDGMEFTLRTPEGFVGRIYAYGFYDRCFFRGNGGTVNVLRISGPQGYPECGTQRYGDTMTNIIVVQFSDNVQTGRDKRFNLTCMFRGPGEAVVTSGYIGAGSGSPIPIEYLPAENSMSNKVRLMILYQGRPTTTIAVGDPLTFRLESQDGYSHATDIFATNVVARDPYSGRSVQLIDNYGCPVDSLVFPELGRSRDNDALEARFNAFKIPESNFLVFEATVRTCRGGCQPAYCPGPSGRSEPSFGRRKRSVENGTDFAGTAEPLIAVKDLDEEDDVVSIVNATMVNENATNAKEKDLSSSGTPEAAPGGEATSTSEMPEQVREMIEVFQSREEMQQDTVARKMVAPIESVCLTHAEYYGLISALILLVILLISITFAAGIGYRSYWKVFMKNRTLDRNSPVNSFSPSALHNVSGSQFEASGRTHSTASRGPQVRSPGVSLFGSGLQKTFATGNLSRMCQIPVMNPLSRNGAAKSEFDDPSEPIYTDPSLFERSRNRCKRHSTQSRRFFFSANHRKRNKFHTSSQRPCSKLEYYDKLKKKCRDFPGGGILVIMDHSTKCAHGDSGLHTFSRRDYYYVCHPEGVMIGLCPESTVFSDTEKRCIGQTNNQPSTIKVHDESRNCNIIVPNCNGVGLFPIPSNCSFYFKCQEHNYDFYQYIYQCPPGKVFHPDLLRCSSSNKCYDGHVCINQRQALSQTLHGFAKSYFFSQEDILNNFNKDYFPECHILGQFRTAKDCTLYYRCVPNMDGSFYQIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZH9</accession>
    <name>A0A084VZH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011195</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011195-RA">
        <property type="protein sequence ID" value="ASIC011195-PA"/>
        <property type="gene ID" value="ASIC011195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011195"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="15223" checksum="5FF2775EE3A7E360" modified="2014-10-29" version="1">MVQRPWAWEADIESGSEIHNRFSGPTLHRPQSLPLCNWYRQTFPCKSSPVELVPELLGKGGWRSLDDSPGFRVPVWKASCSLAVQIVYRMVLERNVTPTRHDDYSVTSLARPGFATLLGVVAFQTTSATWQRHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZT9</accession>
    <name>A0A084VZT9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004735-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011287</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018958">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZT9"/>
    <dbReference type="STRING" id="74873.A0A084VZT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011287-RA">
        <property type="protein sequence ID" value="ASIC011287-PA"/>
        <property type="gene ID" value="ASIC011287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011287"/>
    <dbReference type="OMA" id="GEDYWGR"/>
    <dbReference type="OrthoDB" id="10263520at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF4">
        <property type="entry name" value="TECTONIC-LIKE COMPLEX MEMBER MKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="339" mass="40073" checksum="6E875B004D5BABD5" modified="2014-10-29" version="1">MTKSYRDRNPEVNCRYIFKQSTADRLTIQKIHSLIDIPTMKGLNMHLNREEIPENYSKESRIIYWQEKVFSQHELKYYGFKENCKTEHQKTYYKRFKLESHVPSMLFTYVEGDNFSPDDLDNPTQHRFSHIPDVDKQSMYLMADLGEDVLMFSIQWFPKEGILLVYPDFNRMCIDPYYHEVRGSNLQMYHYSLEKCTSTGDILEAHNIPTHVGATSMNKILDALPLARDERFIMPKHLKQNVLILLEIVSATAFKYDEIHVRYQIVLPNDVKTTDENATLLGSTHSSKNKIGYWQFGHCHELFLIMSECEEMHNSGFDIFFEVISIDSWQREKYLGYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W065</accession>
    <name>A0A084W065_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001252-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W065"/>
    <dbReference type="STRING" id="74873.A0A084W065"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011548-RA">
        <property type="protein sequence ID" value="ASIC011548-PA"/>
        <property type="gene ID" value="ASIC011548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011548"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007939"/>
    <dbReference type="OMA" id="HICGASA"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="40"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="21851" checksum="C08003D85FE9C35C" modified="2014-10-29" version="1">MYKEMDHLYKRRILSVSVPRFIWASVVGALESPPLASGRIVGGSNVDISKYPYQVSLLNDGYHYCGASVVAAQWALTAGHCCNGYDVLSLSIRGGSSTNNQGGVLFTVEKLVLHPSYDSVNLNFDVCMIQIKETFLGHPNIAIIPLSNSDSIPSNELGTVSGWGATQSDGETVLQLRATKVKIFTDKSCTAATRNYVSLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0Y6</accession>
    <name>A0A084W0Y6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011614</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0Y6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011614-RA">
        <property type="protein sequence ID" value="ASIC011614-PA"/>
        <property type="gene ID" value="ASIC011614"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011614"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011614-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6559" checksum="A3C8BA517B3080BA" modified="2014-10-29" version="1">MQQPRYSPAPPPPVTIRPQMAPRHQTIPNLTMVEMLESMGNTAKILSTEILRFAASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W169</accession>
    <name>A0A084W169_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011793</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W169"/>
    <dbReference type="STRING" id="74873.A0A084W169"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011793-RA">
        <property type="protein sequence ID" value="ASIC011793-PA"/>
        <property type="gene ID" value="ASIC011793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011793"/>
    <dbReference type="OrthoDB" id="7787442at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="14603" checksum="00196DB4E3DA932C" modified="2014-10-29" version="1">MALNDDLRYFSYERRRGQLLTEKGRERRLGNAKKLLNLLKHPVEPGTLWFFSDEKNFCQDQNTQNNRWLAYCPADVPRVPQTKFPQTVMVFSCVSSEGDVNFTDGHRMFSANDPTTDSVELLEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1I1</accession>
    <name>A0A084W1I1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP011554-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011907</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1I1"/>
    <dbReference type="STRING" id="74873.A0A084W1I1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011907-RA">
        <property type="protein sequence ID" value="ASIC011907-PA"/>
        <property type="gene ID" value="ASIC011907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011907"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11195" checksum="F42B68F6284BC3E7" modified="2014-10-29" version="1">MYATGRCNREKPPCKYFHPPQHLKDQLLINGRNHLALKNALMQQMGISPGQPVLPGQVPAVVSSPRQPASSSAVWCRSPSTQDKRDRDAFEAVSAQSNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1P0</accession>
    <name>A0A084W1P0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002393-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011970</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1P0"/>
    <dbReference type="STRING" id="74873.A0A084W1P0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011970-RA">
        <property type="protein sequence ID" value="ASIC011970-PA"/>
        <property type="gene ID" value="ASIC011970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011970"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010235"/>
    <dbReference type="OMA" id="WWTSNIV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="333" mass="37346" checksum="80B9FF6A7D4AA4C6" modified="2014-10-29" version="1">MYQPLEKENLFTKYSRIAGVVAAYWVISILTVFVNKALLSGLQLDAPLFVTWFQVLTSSSICFIMSCLGKRYPQAITFPEGNPFDRDTFRKVVPLSILFTAMIATNNLCLKYVGVAFYYVGRSLTTVFNVILTYLLLGQKTSSKACLCCVLIIAGFWIGVDQESLTESFSLIGTVFGVLGSLSLSLYSIYTKRTLPHVNQQVWLLSYYNNVYSAVLFIPLMIVNGEVQEVLNYKHLLEPWFWGVMTIGGVCGFAIGFVTTLQIKVTSPLTHNISGTAKACAQTVIASSWYQESKSFLWWTSNVVVLLGSAFYTRVKQVEMDQTHREQMSSQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2D1</accession>
    <name>A0A084W2D1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012317</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019600">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2D1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012317-RA">
        <property type="protein sequence ID" value="ASIC012317-PA"/>
        <property type="gene ID" value="ASIC012317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012317"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022458"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="7745" checksum="9761476F930540CA" modified="2014-10-29" version="1">MPAVSKPSSGSSDAASHPAPSDSMEEEPAGGGVTRGPTSDTDRTDSLADDHQIRRRHIDANVAEGPSHSNNHSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2K4</accession>
    <name>A0A084W2K4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012234</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2K4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012234-RA">
        <property type="protein sequence ID" value="ASIC012234-PA"/>
        <property type="gene ID" value="ASIC012234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012234"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10139" checksum="0B37FB7D5DA05870" modified="2014-10-29" version="1">MQPAAFRSSALSGNFSPSVHRSRALPDDPLTPDPVADGYTTDNNLAFHNLYNTSNNDDRPMRGSLATNMACRTLTLAGEAFADRWSANADYGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W350</accession>
    <name>A0A084W350_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W350"/>
    <dbReference type="STRING" id="74873.A0A084W350"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012531-RA">
        <property type="protein sequence ID" value="ASIC012531-PA"/>
        <property type="gene ID" value="ASIC012531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012531"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019167"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
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            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1611"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1810"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1887"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1930"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2032"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2044"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2083"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2143"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2207"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2697"/>
            <end position="2719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2924"/>
            <end position="2949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3021"/>
            <end position="3056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3105"/>
            <end position="3138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3148"/>
            <end position="3157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3251"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3266"/>
            <end position="3279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="3308"/>
            <end position="3325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3333"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3345"/>
            <end position="3354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3405"/>
            <end position="3429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3429" mass="354995" checksum="CAB6A501E59ECD1F" modified="2014-10-29" version="1">MIPQKQPPAQSPPSSSLNATTSSSSMTTTVVSVTTAGPGGAAATTTTTTTTMVTEKAAVSQQSAIPRQHPKKRKFDLAELEEMSSHRPAPPQPPPTTPVASSAPEGKPSAPQPMDTGGGSGTGAQNGTGHGSGSFDVYSSAGGASNGNARSNSSSSSSSSNNNHNVRPGESVTLVEHERPGTTGSSTNVYRERTLNCNDRHPAESPGAASPASNGTPSGVQHRDSPGLSQSSSASTTMNLSTSSSAHGAATLLTIAANHGSIPVQHLQHRPSVQYHQNHHHHHQHHLHHQQYNPPSSSPGMVMVGNGAPSSSSSVSSAATGATVNRSQSYTISTIAVQPTASPPVAMHSAPSSSLHQQQRQQSSQHVLQHPLHHPHSQAIGHNRQILLTVDQAAMRQQQPQQQQQQQQVLRLHHTSSPAETFYVSKKLYTTPSYGSPGGYKSSATPPTSLATTSTPSPVHQLPAAATFSVPQHHYHHLRQQSPPAPPPSSSSSASGSLMVSEELYSPQPLHRSHGPSSSSSMAPETGSTSVGGRSTTTTTTTGSNATTVIDLSEWINHRVLARRKDVYDSGRIRTTAAPSTVVIGFDHPEGSQQAYDNVLDVFDPHHRQDIIDDVRPALTDLQPGVRVCVRATCVHPHPGTTGGGDVFVEGIVKEVHANKQFSVQITGGGGDVSDKQELRIVKRVDMRLLKPPWWDELEDALDGGSVSEAGPSRASAIMNDHRSSSQQLHAETGGSSKSQHQAPAVVSYIISGDSLLHHPHGNGSGGSSAESGAPPPTIIYAGGAPYKGISITQGRGVASVVTGSSQEQLATVHMPLQLHHVLPASSVSGEETPPQHHYRSAATSPFQSTQLSAIGEHHRDRDIAQGGSGNGGHYGARSHSHHSHHQQTQMGGTPAPAHSGNTVVPLVVASSSSGGSGSAVAGSSSSSVLRTVSPDDLRTTNRSYDYESDDEVRSSFPMDGETEKYSGSSKRSSMQSRGSTSSLLDQRSTPRSQPATPRSQAATPHRFKKGDVVSTPTGIRKKFNGKQWRRLCSNETCSKESQRRGYCSRHLSQKGNALRSSTSSVTNHFNSRSSSKTQLDEETSRDSETSPHYRVARQFDQDETDAANMLVSLSSSRSATPSNSFSSPTGHGSSPLATQSPVMIGNRQNLFLPIGSPAPLSEPHGGSGSIGSGGSKYKTNTPSPNPHGITGGGIGGVGGGVGGSGGSGGSSSGGGGSIGIGSSSHHHQLIRPESLRPAQQPPPHAVTVATAPPPTGHATSVIRMSPLYTQHNSAHQSSLYSAYSQQQGGGSGSASASSAASSASSQQVIVDASTSGGSTTSGGQQQQQHHPLSLQQQPHALVTTSGGRLQQVNPGQVHLVQQSPASSHLGQPPQAHHQQQQQQQQQAVLQQHIQLQQLAPQQQQQQHTVVLTSQHHHHQALTMPKNGISTGSTYQWHALLPIIHGPSALAKAAASGNTSHLHHPLLVASPGYGLPLPPPPISTQGAPLGTSSHPGAAPSPLVVSPPSSSSIGSTSASHSVNAATTGGGTNATTITTASTRLSSSSASSSSSAAAVGAIGPAKKLYTPPPPPPEDISIDDDDQGDDDVFEAEPVKTNSTTNQNTSNPSSAVGPSSKTATATGGANSSHSYLLGSTGGGSSGGHMLVRGLDIEAPAKLATTGATESAESIAKRRTQSCSAALQAAAVANGAAGGQGSGGGGGSSTPKEPQSPLNKKDAKIRRPMNAFMIFSKRHRALVHQKHPNQDNRTVSKILGEWWYALKPEEKTKYHELASEVKEAHFKAHPEWKWCSKDRRKSSSSAKEGAGGGAAGLNAANSANSNSRGRIDSFEGNDSFDEKSPKTPSELMTPGAMGGGGGGSSNDIIPLTVAPYNTVDDASETAGMMMPPTSTTSYSSQQQQHQHQHHGSTFSIAGGKHNSSNNKPEAMAVDDGPTDGDEQDKDDERMDISVGDEQMDEGGVDGGGGAGRGSISDDDHQMVIADEEPTARERKHEIDLKCAEKVSDSDLDDHNSTGAVCVKGNKYDQEKGKHRKASATATSTASTTTKVSESIVSDDNGPSSAGGLHYHHASNGDVATDYSIKALTTSVPTTPGGPNSSTSSRGAFKTMPQSPKTLGKQDHPSSYLLSPAPSTPTASIKLEPAENLSTITTSSSGGRSQSDTIFNFSTAAIKEQLQPAVGGGNTYHHGVEQQQPKQQVLVAVSSNGDGHLTTSSITSSTGGNTSTTTSTTTTTVTPPGSSADKCKSILSLNPTICYTISSVNGNNNHNNHQVVATSSNANLKPSTNAIVMSMKQDVAHHSNHQLSSSKTHCINSNTTTTGVVTTIASTICSTTTSTTTTTTITKPSSPVVSVVHSNTDTIDSGTANNVLEQDACMDVVNVVGTSSGSLSSINPPVVTVPTATVLATPTGGVPTTYILNPSNGGSSSLVRSQPMFARTTTGAGTAGGGVLGTIKLEQQVQRQFSVRLSDEATTTTSASASGGGPPSLVYETVFIERPQQPVVKQQMVSAAGTNGLIIGTPSSGTSGTGASSLPTGSIIVLTQASLNELLLHGTTTATQQQQQSCPSLGTIVNAGSQSVAIATTSSSNASVVGSSQCANNIIPLSASSSVTNSCTVVSPADHTTSVTISTTNPTTSSTTLTNTNDRKCIRTTTSHSTESNHSNNIPSTTINTITTTTLSSSYTKQSIIMINPTHLTVLPVTPSSTSSSSSSTITTASSISSNLPSTLSLSSGVTGSLLQHQHHHPGQTQSPAATVTSIGYSLLNSNNVVTMATDLSGGAAAMTTPSSHHHPGTATAVLTSTQRLPGRQKLMLCPQFALVLPDNQQFTLSDRSKISFASLSTATGSPAYAIKPAQPHAATTTFFTTSAVCPSSSGASSTSSSSTTSTIAYALTSPSPSSLPVIGPTTRLASNGSVKLTTILPTTVASSFTIPSSTTTTTSTTISSSSSSASSSSSSDGVVNVSGKSSTTTTATAAAIPVQYLIQGNRISNLLISTTQGYPAQIQQYSTVKQEPPESPGAARHLPITPNSTSTSGGSAGNNSSSSSSSSSTSSVASGDGGTASTVSVAGTEPDPTHEEETDDDFGVPPESKKFILAPTPAQLGRAPLQRRQMSGGSNSSNSSNSGTLSEQVQQQQQPQNNGTLQQQSSMMTEEDEEMHHPMETNHNHTAMPSALPTPTSASMEDYHGQISPSAAKKAFFRKAKPDDMDNVLRQVDFEKKFKTLPQFKPEDCHSPSAITASSPRVFTQNYRKKQTTTHKTLTEDDQHNNLHSDGSAAPLSSTATPSSSYVIGNRFFGPDFNMEQYKEMTAELGRAGGVGVGAGTTGGGGGGGGGGDERSPRTPKTPSQRSVNSAEEKGHRKILEQRRNLVVQLFNEHGMFPSTHATNSFQLAHSDIFPNKQSLQLKIREVRQKSMAQQPGFTPQSAGPITPTDINSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W503</accession>
    <name>A0A084W503_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013242</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W503"/>
    <dbReference type="STRING" id="74873.A0A084W503"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013242-RA">
        <property type="protein sequence ID" value="ASIC013242-PA"/>
        <property type="gene ID" value="ASIC013242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013242"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001757"/>
    <dbReference type="OMA" id="TRFYNRF"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013242-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="406" mass="44517" checksum="8F52730C437D7E98" modified="2014-10-29" version="1">MWNSAFGQTGKWQRASAFPCWCTWIRDVPPVLHAGSIQHQRTFHVPPQKATASATDHFRVSFPPSLGEPAAVLDSIIFRVQQHPQVPNFTQCVTFGFFPTPGLETAYNLFCVIAMYFLPLMIISGAYTVILCEISNRSREKETSDSNTTGTLRLRCNDLTHIERARQRTLRLTITIVVVFVWCWTPYVVMTLWYMFDRESASKVDVAVQDGLFLMAVSNSCMNPLVYGSYAMKCRLPCRRRNTPGGVQTPNAAQRRSTDAVSGIIGPHSDRLTGRDNKDELLVADQRSITMNHLSQNGGIALLQSTGTAKPKADPEPCQASTTGRLHPSQLRSTGGVALTTGAGASSTVVGTTTATTRFYNRFSSGITNGTNYHTNTSRLISGGIKPATSIAHRKAGGEKVTESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W641</accession>
    <name>A0A084W641_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010193-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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            <end position="236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="236" mass="26992" checksum="D3F696888D088E86" modified="2014-10-29" version="1">MKLLLLVVASLVAVCLAEPKPAINEVKPNQPLQKPGRFLSLPVPEKCASRPKQFSYRGHNYFYSAHVPALADKRVDWLDGRNICREYCMDLVSLETQEENNLIFRLIQQNDVPYIWTAGRLCDFKGCEGRPDLEPKNIYGWFWSNNREKIHATNQIPNGWGYNPWSKSGHKKIPQPDNAEFDINQTTESCLSILNNVYNDGIGWHDVACYHEKPVVCEDSEELLNYVSATNPGIRL</sequence>
</entry>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC013704"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        <source>
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    <sequence length="672" mass="73506" checksum="E116CC6DFC41866A" modified="2014-10-29" version="1">MELIKSTPAAGSEQQPQPSQSNVYDEIRQEIDKMDPYAETITLTYHLRQFAELFLRRINDDQTLNTLFAHLNEAALADNKFAVKMATVFGSHQLGDAMIQETKIRNAMIGTLQQNFLAIERLKQSDRQRFYNSVTLLGEYYNRKKVLHGRRINILGQSLLLLLTSELEQEITKSTATQQQQQQLYQMDAEFAKLLLEQITLNGAVAKDEHRKEITDLLFTIRKALITVPNLCSRTKAFLLMALDLYHSNLAEDLFAKLYSKYLNEPQQPAVTTTTTSQSNESVRVEQPSGESKQPTANGECAVRGQQEKSSPEAVVTPKATGIRANSNSRGTPTGVGKTPPSPQNGARTIHDKENSRRSSSRTKAAPEKKTPPSSQASKRNVRVSEDGKIVATITRDSPTTPTKKAPPSPTVGTIRTERSPVKKGLSPRLERLAALPKITITCSTPSPKRQVGNTSAISPRAVLGVASAKQQQQISPKQPPKSPIRTPTPKSVPEVHKSPEGSRQGRAKLSSPSQGTDSVETNKSKTVPRDEGTLPPKECAEKHPENDRITPKSSPSTEVSKETTNQVSNGSGHIIESGSSSLHAANDAGKLQALNNGVTGESVANGTSEGTVKAENTQEAPEGAAKPTVKSYFREDNMENLSWDAMNALDDDSPQKLNPHTKSFLSFLADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6X2</accession>
    <name>A0A084W6X2_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00013931</name>
    </gene>
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        <name type="common">Mosquito</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ASIC013931"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB45966.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13518" checksum="52DA17F4F7AC65BE" modified="2014-10-29" version="1">MEWSPWKHSSSLDPSASGGFPPARFHPLLPARDGIGKAQCIRMTRLIASEKVALGQDIQISRFSTAEERQGLDTGRCESGXXXXXXXFSFTRWQQRPVGALMQSSIQPAKRDRPWLAIDRS</sequence>
</entry>
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    <accession>A0A084W7L1</accession>
    <name>A0A084W7L1_ANOSI</name>
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            <fullName evidence="12">Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7</fullName>
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        <name type="common">Mosquito</name>
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            <taxon>Pterygota</taxon>
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            <taxon>Nematocera</taxon>
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    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="1.14.11.63" evidence="11"/>
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        <property type="gene ID" value="ASIC014209"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:peptidyl-lysine 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="jmjC domain-containing protein 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cupin_8"/>
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        <property type="entry name" value="JmjC_dom"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
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        <property type="entry name" value="Cupin_8"/>
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    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="137"/>
            <end position="314"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066577"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014209-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="319" mass="37365" checksum="21EC57A92A115D6C" modified="2014-10-29" version="1">MSNSNIREAFQVLTNEAKDLFLPASIPETFGIPTALEFVRDHVAKNLPVIMREAITDWPALEKWNSKYFRDTIPDKEVTVAITPNGYADGLAMHESEEHFVLPLEQIMRMDEFLSMLDNKNPNSVPYIQRQNSNLTEDFQELWEDVNEGSLNFASEAFNKQPDAINFWMGDERAITSMHKDPYENIYCVISGFKDFILIPPIDLHNVPRRQYPMGIYMQENDDKIVIEPILDEIGKPRLIEWVSVDPLEPDLSRYPSYADATTYEIRLNAGDMLYLPSLWYHHVRQSHKCIAVNFWYDMEYDARYCFYRMMEKLCNYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7M3</accession>
    <name>A0A084W7M3_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014222</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ASIC014222"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13170" checksum="757C7CBE82771DFE" modified="2014-10-29" version="1">MIRRGPNARGLESPTLHSTNNRIQSGPHQPSGRLCYERSFRIHRSMATEPNVFTSHGSPTSVSGRFVCGWMFGEVGYAGNRPSALEGANEFGFEIGPFVLPFEMICAERFMISWQGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W875</accession>
    <name>A0A084W875_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ASIC014418"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5001784484" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB46419.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014418-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55303" checksum="4C2AC693FFB8BFCE" modified="2014-10-29" version="1">MKMNWGCNALPLLVLVVVLGTTLQHARAEPRPDFGIKAVLSGTPRVITLSTTLSNTFDKVDNTNLPLVSGYNLLNNMKTALLQIGTKITTKGTAITTALNTLAADKSNVNAAPLFQAVSTAITELSQLVQTGLTAELAVLKQLNSKSLIVDGLGDGFRSIVEKLNGLSGALDRLKAGVIAARDAPGNSPTAVSSNNLRKFITSTMVPDVQDALTRLNGEVPSVQYVIESAQKRLVVADAFISDIKDEAQENVGFVRDDFQDLQNKATIVGENIAAGFDDLVTPVYNAQLAALSAVQSTIEGISTYADDLQPALTSLDLLLEADFLGTLTTSLEDEFANYNTALDGSIGTDTAIKSFFVAEACGVVKSLVNSLAASGDYAEYCFVKYSNKAYSQFGIAYYLLSQCYQVEQVRLERLQDLTATITQMIIYDIEDLGEAISSCAPLNDGAPCLTLIGPHYEVLATTIDDKQTYLLNYVDKELKLSLQRVGACVAVSKYSMVVALQPIPANLATCNASGYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W908</accession>
    <name>A0A084W908_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014698</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W908"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014698-RA">
        <property type="protein sequence ID" value="ASIC014698-PA"/>
        <property type="gene ID" value="ASIC014698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014698"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15699" checksum="55A6DD11CE1431C8" modified="2014-10-29" version="1">MANTSNETVNVSTPPAAETPCGIIIFNQCQSTTTSTQSKTFLLEVLREVVSQKGNCVFPETIGGCWRGSEEDWQHTGRVSFLPASTTIPAKVIVSLDSLSYELYHTRYTYRFTSSGGNIKPDRKQKTRGYIHIPQAPIGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W933</accession>
    <name>A0A084W933_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014728</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W933"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014728-RA">
        <property type="protein sequence ID" value="ASIC014728-PA"/>
        <property type="gene ID" value="ASIC014728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014728"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7592" checksum="8BA9C61682247007" modified="2014-10-29" version="1">MIPYLTDRKENRPIRGEIPLQPYPRPSTVEPLDYGRSMLETIVEVYCFFLVPTHNLPSLSTNRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9U6</accession>
    <name>A0A084W9U6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00015000</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525325">
        <property type="protein sequence ID" value="KFB46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9U6"/>
    <dbReference type="STRING" id="74873.A0A084W9U6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015000-RA">
        <property type="protein sequence ID" value="ASIC015000-PA"/>
        <property type="gene ID" value="ASIC015000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015000"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004708"/>
    <dbReference type="OMA" id="DSRHANM"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="189" mass="19639" checksum="63AE000B6BBFCFE8" modified="2014-10-29" version="1">MDHSEHHDDSRHANMSGSGVGHAGHGMVDHSAHDHTMMEHGAHGHGHHGAAGAMGAGGGGPGAMVHHMMSMSFHGGYDETILFEQWKIDSVGGLLWSMLVIFVMAALYEGLKYYREHLFWRTYNALQYRPVTVTEKSNGNGVAAAGGTSTNGGTGDGLNVLMGTGVGSGAGGGSSGGSVLNEDTNRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAZ8</accession>
    <name>A0A084WAZ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015639</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAZ8"/>
    <dbReference type="STRING" id="74873.A0A084WAZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015639-RA">
        <property type="protein sequence ID" value="ASIC015639-PA"/>
        <property type="gene ID" value="ASIC015639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015639"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012745"/>
    <dbReference type="OMA" id="EYDKDCH"/>
    <dbReference type="OrthoDB" id="7907111at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF104">
        <property type="entry name" value="AGAP010328-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784470" description="Lipase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39340" checksum="A2A3D6B96327F885" modified="2014-10-29" version="1">MFGSRCVLPAAVTLVAFLLILQPASADRFQDNIFFNYYNSSGELVHIYNLTENNTYEYDKDCHPGSKFAVVVFGWKIGCDKYFVQDLIGNLTKHRGGCVICMNYDRFAQLSAYARLRRNYKEIHGVLRQKLEFLEQEGFSPDDGYMYGFSFGAQVVLAAAKEYGTRKLKEIDVCDIVGTGFDVSDTNAPNHRTAAKNVQCIHTSRNYGTRHRTSCHQDWIMGDCGINQLAAPLSPWGSHGVCTLFYNSAFENDFVASAKPTNCTAESEVRSWPEGFKMGYSETRKSTVRGQLFSPTFAVYPFHVNVTAVVNASTTGTGPGPNDIEQFPGYEFRSATNEFLLDDEELDSAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB39</accession>
    <name>A0A084WB39_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB39"/>
    <dbReference type="STRING" id="74873.A0A084WB39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015378-RA">
        <property type="protein sequence ID" value="ASIC015378-PA"/>
        <property type="gene ID" value="ASIC015378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015378"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018060"/>
    <dbReference type="OMA" id="IRMATYD"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="87"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="310" mass="35955" checksum="D7D0DF29D6920981" modified="2014-10-29" version="1">MVNLRPVSQALHEKAKRELNERPERIEEDLAALRQWLARTPHIRARIDDQFLVTFLRGCKYSLERAKEKIDMFYSVRTAIPELMRNRDPEAARIRAIIRLGVGLPLPQTDGPDAPRIMLIRPGVYDPKQYNIEEVIKVSTMFNDIMMLEDDHMVIAGQIGILDLANVSTSHFLQFTPTFVKKMTMMSQEGSPLRQKGFHYINTPSGFETVFNMFKTFMSEKNRSRLYVHGSNLESLYQHIPKRLLPKEYGGEGDSLKDITAAWEKKILSYREYFIEEDQYGTDERKRVGRAKTAESLFGMEGSFRKLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBD4</accession>
    <name>A0A084WBD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP011469-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00015488</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBD4"/>
    <dbReference type="STRING" id="74873.A0A084WBD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015488-RA">
        <property type="protein sequence ID" value="ASIC015488-PA"/>
        <property type="gene ID" value="ASIC015488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015488"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024361"/>
    <dbReference type="OMA" id="FFECHID"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="386" mass="44779" checksum="95135D9249A60DDB" modified="2014-10-29" version="1">MVQILPKLKDPLAVMPFLLRIQTIAGLWGDRSQRYRFYLIFSYFCFMVVLPKILFGYPDLEIAVRGTAELMFESNAFFGMLMFSFQRDNYERLVNQLQDLATLVFKDLPAELGTYLIEVNKRVDRSSKIYCCCHLSLATFFWFMPIYTTYSAYRAAANSTEPIEHVLHLEEELYWLKSRTSIVHYTIYAAIMWPTIYTLGFTGGSKLLTIFSNVKYCSAMLKLVALRVRCLANVKEEKIEKELNEIIAMHQKTLDCVLLLETTFRWVFFVQFIQCTMIWCSLILYIAVTGFSSTVANVCVQIILITVETYGYCYFGTDLTTESFGVALAVYDCEWYKFSISMRRNLRLLLQRSQKPLGITAGKFRFVNVAQFGKTRFSEDAGDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBD7</accession>
    <name>A0A084WBD7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015491</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015491-RA">
        <property type="protein sequence ID" value="ASIC015491-PA"/>
        <property type="gene ID" value="ASIC015491"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015491"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006152"/>
    <dbReference type="OMA" id="AYVWAEL"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015491-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30441" checksum="DD18041E1112D245" modified="2014-10-29" version="1">MTFYSRHRKDFGRDSETLRLHSPIDKPLVFIFAWLQASEKHLQKYAEFYHEQGYEVLSVQISPWQLAWPVYGSQKVAGDIVKFLANNEFPRGIVLHGFSVGGYLWGECLVKLTAQPEGKQILAKIGGQIWDSLADITEIPVGVPHAVLPHHPTLQGFLRNYMTYHLKLFHEEATQYYVKCTHLFHHEPARCPALLLVSKTDPVGTEKANLRLRGIWDSLGMKTSMKCWDKSPHVGHFHKHRDEYIELLLTHLRSLDLPNRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC39</accession>
    <name>A0A084WC39_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015856</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015856-RA">
        <property type="protein sequence ID" value="ASIC015856-PA"/>
        <property type="gene ID" value="ASIC015856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015856"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7490" checksum="A420D94C9A65C798" modified="2014-10-29" version="1">MALARCVRPKLQQSWASVHCTRSRSGFAGKRIRSGNRPTGIIGQVHTMEGKVTSRDGSGRAGGVLDLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCC1</accession>
    <name>A0A084WCC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AGAP011192-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="21">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00015918</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WCC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015918-RA">
        <property type="protein sequence ID" value="ASIC015918-PA"/>
        <property type="gene ID" value="ASIC015918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015918"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023794"/>
    <dbReference type="OMA" id="CQIVQLF"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15666">
        <property type="entry name" value="ePHD2_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19171">
        <property type="entry name" value="SET_KMT2C_2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000003">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.360:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
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    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2461"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2856"/>
            <end position="2871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3042" mass="323129" checksum="ABF68E91CABB05B8" modified="2014-10-29" version="1">MEHHEQRLLLEDMVEQEKREQANQLQQVSEMPANLLADQQYDGMMNNPQGIVRGPQQSAGMVVNQLHQNQQQQQLQSPPGMHGQIQMQSPNGTQFMLQQQQQQQQQRMNTHWRPQTPVQTTAAAGAGTVLGGQISSQPIATNSQMAKTTTTLQTGAAATAVSSPATSTDPSANKSIPLFQANLQPQPPQPPETIATEQDRVLQINYENWLNQQNTVLSNQLKYYETEIVKLRKVKKQLNTKQRHLRKQGNELTDNDAKELQKITADHGIIQKQLENARRQQRQHSVILQDYKTKHPTSKPAASTPTPVGAPPGSSPAQSLIAPPSPLMSPSPSSQPGSLYQPPVQSPLGNPILQPNQSPLHSPSPLLSHSPGPASVNSVLQSPGGNHTNSNSAMSPYSTMQPSPRIGTPHSQIDENPFSPGPTGGPSPSPSIPGRLTSPAPRMTSPQHRVGGQQLVGATGRMHRNRITIVQKSLAGTMGAVTLKPVGQTLVDAEVSLNSVAHHGTDGDEAIIETFSTTPTGYEIVGSPLDSQIVAGGEYNLFSDDVVECVDSEDGGGGGTGGSSGGIMSSISKKDSRTVTVELLMDDSSKDKPLLGSSEIEIVESVDDSNITTTAEDFEAMIDSRPKEGTTADGGVSETASSAKSSETITVHQHQQQRKEEKGPEKTMTPTKEMTIVTVQHQQQNSPKPIAYPAGTISIQKTLMQNRPIVSAAHQRLVKDATETTAKLSIGNTTISVPILKKSFPMATASKTGGGAPDHQNAVSRAATTATTTKKILNTSGLSISNISKNSAGGTVIAVAGQKINTTSIVTLSSLNLNQSAPFITKTFARPGTGAVTIQQQKQLQAQQLAVGSQIKIQQAQALATQLSVANVAVASTNSSLTSTNTATSVQATTVSSQQHQPQIENIILKSKPKAPSPSLSYSKLSTLTVTQDTSLPTKIFEDDSISPDSSISQEDADQLPLEKAEATGSDSLGDAFLQATEAAPADGNQQQQPDAAAGKSKQNAPTTTAATTTTIASTIPVHVISKSRENSRSPILHGGERQSTPTGQRIVSSIPQLSPLSQPNELTLNAMNVSQQVRSIMSSINVSSATTVTASGASSGQQTSTPAATVASSNISTITFDTIISSKGDNMSKTETIASILKTVSGKTILPAAAIASNSANLIKVSEHQQQQQGGGMAAGPGLTTATITSIPGTKLITQQLQLSRIPGQTIGGGNNNILVVKQVRAPNKQTGPGGGHHQKQLVVLTQGGPGGQAGGGQQIKLQPHQQQQLASGNSVTIQSQPAGGNSGGAGGGTSGQGGSFVKITTATPTVVSASDSMLKTIVSVNVTPVSVSAAAPSTSILSATLSQPLLKSSNASAISTLLQNQLQNATAFRRSKSTDEAPGHHGQERGESASQILSKRLSLEAANVVKIEPVDSVSDDTNVSSSSSSMTSGSSGATLPTAPASVVGSSSAVAKPDASTGSGCKFSSMSSSTSSSSSSSSTGGMSKSEDSQNVLLKQLLQNSGGSSSSSGGGGGGGSSVGITGGSNPSVSSPAPSPSGRAVPSLITNQRAPSLGVVSSLQAQLARPVIPPSANPPAIQIISTQSIAAAITSTATSSSISTPSSSSTSSSLSMTTTPSTPIPSSSAASSTAMSSVTSATSSTPAAVVTPVETTKPKLISRETSFVSKPAGISSSHPTPNLAANMLAASIKKEEMLQAAAAAAAGFPNAGATIAQGTTVQVESGSITVTQIQTPQPVTSGGSQLPMVVSTKPPQQQQQQQQLTIQQHQQATNPNTIGPAGGTIGETNITIIKREIIANQSPQTTVQASTATTTALPTSGGISVTVTTKNTAGEPDSKRFAPSPVVASDSTTTSAPGSRPTTPQQQSTSRPASVTPRSGTPVEGKESEQTAGGQQQSPSIATTTTMSSSTVTTPSTMGPPTPLIMKSSPAAAAPAGGDQMAPGISSTNTAIATPANKEGQTQDAAPQVPEVPEKTAAELAIELKKKKRREYQKNRRQMQIQSNKDNQSHSQAKKKPKKSVKVEEDYDTCIDNLMAQLRQLPPMQILEPQLPRNYGVCPVFGTGDLAKFTNLKGYSIASGDLTGSYGSAQLPSVADFYNTKPFGVKDPPPEPVPTSTQRGFYDQEFAPIKFETEERHRYEFVRDRDLDSPDTIISTSSPECIRWESPICFPGLRLIKEEPAEDDQVTVYRQMSPVIPILAPIPIRLRKGMTLSAEGGGRPNGVFGSNESNKENEGGKDTVIGGIRSRFGPPTPLKDTSNVTVTLTLTSSAAEDIFGVLRDLANILDIPPPTTYQIVERTMSPTSQKLGLYRTKGRDGKEGTSIDIQTILNGSARFCRHCDVVILNSIIIAQASEFPLLSNGGSAAASSQELESEELYFCGEQCYRQFKWRPTNILDEDGDSTRTNEQTVLLPGGGEGPPGATALSGVEIKQEILEDVEMEEVASQNSSTTDASLSGERKKKHPDDGASERDVLIGAPPAKQVRGVRYKTYSPNCFPVQRFKKPTEKEITETLFRMSITVTPSPKMPDDTRRCIFCHTVGDGVADGPSRLLNYDVDKWVHLNCALWSDGVYETVNGALMNLENALQQSLTSVCAFCNNLGATIKCFKTRCANVYHLSCAMKDSCVFYKNKTTMCQAHAPKTEKDSELTTLSVQRRVYVDRDESRQVASVMHHSESSNLLRVGSLIFLNVGQLLPHQLQNFHTPNYIYPIGYKIIRFYWSMRHPNKRCQYICSIADVSGRPEFRVLVKETAEPDIELRDATPKAVWHRILEEMAQLRKNCHIVQLFPRYLTGEDLFGLTEPAVVRILESLPGIETLTDYRFKYGRNPLLELPLAINPSGAARTEAKLKHTLSWKKPHTQRTGSASQRPTFVPTSSPAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVFLARSKIQGLGLYAARDLEKHTMVIEYIGEVIRTEVSELREKQYEAKNRGIYMFRLDEERVVDATLSGGLARYINHSCNPNCVTETVEVDRELRIIIFAKRRINRGEELSYDYKFDIEDDAHKISCMCGAPNCKKWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD95</accession>
    <name>A0A084WD95_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Histidine kinase, HAMP region: chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016258</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016258-RA">
        <property type="protein sequence ID" value="ASIC016258-PA"/>
        <property type="gene ID" value="ASIC016258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016258"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016258-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="8901" checksum="560DFC25BA33C986" modified="2014-10-29" version="1">MVDTTLHARVGGFLMMPVAATVVPASGVALRHETPFGRAALGPETATVAEVRRPTVYDGGDEGSGGGRFFTLNLKLNDSARGVGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEC3</accession>
    <name>A0A084WEC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005786-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016880-RA">
        <property type="protein sequence ID" value="ASIC016880-PA"/>
        <property type="gene ID" value="ASIC016880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016880"/>
    <dbReference type="OMA" id="PFNEYGL"/>
    <dbReference type="OrthoDB" id="7744568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784839" evidence="2">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="291" mass="28262" checksum="23BE73FBEC4D714D" modified="2014-10-29" version="1">MAASFGRTFLQVAVLVAGVLCTGTEAGFAASPLLAAPVATTYLAAAPAPVVFPAQGVLRSAYSQVVGRSYAPTSFVPVATSLAYAAPPVVAPVARAVPTAYVAPQLVAGPVLKTVAAPSPLAVPLAARFAAPLPVAAPAPVAPAVRAAAVPAAIAPAFAPSAVLASRVAPFPAPVAPAAVPLGSSAPAASLLGVIEARDASAPAGRTGQTTFLTAFGSPEGIRIGFEGTSLAGVASTSVESARSAPAPNPQNTASGRGATTPAQAGSNQETFGVPQPAPFPEYGLPAPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFE7</accession>
    <name>A0A084WFE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP013097-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016940-RA">
        <property type="protein sequence ID" value="ASIC016940-PA"/>
        <property type="gene ID" value="ASIC016940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023580"/>
    <dbReference type="OMA" id="NSVDCRS"/>
    <dbReference type="OrthoDB" id="7744598at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
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                <person name="Yu J."/>
                <person name="Hong S."/>
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                <person name="Zou P."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3835" mass="414102" checksum="61B2A056035FE056" modified="2014-10-29" version="1">MGPSARRTDRKPKPINMANGRRTCGRKKQALSDHSPRISFFLFRTSFEGSWQLAEDFTRKKEIRAYMYKLREQRLKEFYASNDSSPPYFLMDKASATFGLKKSTVTASHGDSLVDQSFESFKTKEIRDSESPTRFGNAATVPSANSGWQIKTSEEVSDDGKTHTMHTTATTQGTKELEGGRMTFAGHNLESHSEHFDGDESNFVHSKGDQSSTVLVEDSVIEDADSGRTVAGTTRSTTTSSVSSTSRVVRQQQQNGSDGAQQLLDATDFALDSEEKHGVASSKINNTSSSTSTTTTSSSNTMKRSSTNTSDEQCVASAPKELSKDPERVREAFRLAQGAGKVLEREETMVNATTKMITETKRLDDGTTVTTRTYEKLPTAESDQYEHRSRTVRTQHVQEQQQKKQEASPTRTNYLSEVNSSEDQQRSSRSRTATTTSTTSQRISVEVDAAHDSFARSLRSISPTGSVRSVRSNATLVGSGRTSVSPDKGRTGRRSPSRESDQRPDYMRSTFTSERKVSGFREPEQPVGEGRSPSPRKVPANTPQESRGASPVKQDVKKETHSEMCQSSVEETTTHEQEVDSGRTKPPLVRSETYEERCRKILGMPHRPMGEEAKVDAKTTSGSIFSTYDNTVTTVQQQQQQNTSTRSELREQRKKIEQEIRSIERETLKTSASRRTSDFLADERDSMLEERKVQKESSPGRKSSVGTSKEPSPTRQERSPVRVDAKEPSPTRKPTMVKEVSPVRKPSVKEPAAARKSPEKEPSPARKELTPTRAPAEKEVSPTRKSPEKEPSPKRMSPTKEPAVTRASAEREPLPTRKPSVKEVSPVRQSPSKEPSLARETPVKDVSPSRKPATKEDGGTETATKTSKATVLVEQRREGRNISVAEITIVPVMEVSEVRTARSASKVLTKQSSDTKFDRRTTTTSTSTTASNASNRAITNKSSSDFDVTKRRSTEVTTSVGAGGKQRTPATSPDKRRPAAPVAATPTTPSVKQNHITVAKIKINPLRKPQVVTTRTEEWSSTRTSRSQAARKLPEPETDPESSKDTGISDNSEVEETVERVEVSATGTACCRHSGAYAVTDRKDSAPVVRTTGAARASKSYARSSSDNHLRATNVVNRPAAATTAPSSNRTPAVNGRGKVERPVKHVATKTINLSNSSKLSSTVAGNTTTNTSTTTTFDSDHLDNVVIDIQQAKSSREPTPNKLVPIPVSPDTEDTGKPRYPDAVQEPDDERAPSTVQPRVNNIPIFEEATNEYVGCEITEVDEQQESVSAHATRITNLDRVTEDDESLLSVTEKVSKFVHEARRLQESSTAGEAQPRQPQPVRFVVRHEYDDIDEHLKSDECLLSVSDKVTKFISTAEEVKKIRTSGPFVPDGVGKPGADTDVPVSVTEGDECLLSVNEKVNRFASRIGEARGETARHTTPAEDGVTDLGGTEPNGELVAEKVSKFAPQKSPELVKNAMRSTARHTVGEESESELAGRSTNATSITERYRTATVTKQAPAAAPAAGPTPTSPITLRSTEAVKKAKEIFEKGQTVQDARQRDILSRPSIWEERRAKKEALDKEKDQGRKGVTTDVKLTDIGVFRKQSSSTAVDGVQKKPEEPRAVEPVEPEVSPPKSVGTGSRRDSGGAPRAPAYIRDTVSSKKDLFEKRISSSRMQVEYTTQTSQEASTESSTAVRRQSLKQTDRERSTAPSVGDGSKPSYMNHTVASLEHINANQRRESVDHGGSGALHEQPAVARNVNMASTTMTTSTSSSKFGVELKRLDSGNRTSTTTTTTVAANPAPTQAKRKSSGTGATTLTGDVAIEDIFELEVLERMLEAVTGYEQRRRIRAQIRLVKKQRDEQQTASTGRQSSTTVTTTMTTTTMAAKNANGVATKRKDSSPTRTSAMRKTSSTVADSTDSASNARHQMATSTTSTTTTEVMVEKQQEVGKPTAPVEIKQVTTDRFGAKASAKDERPIWATSNILKKASENTRTFKGSGASSLGTGSGTGGSSMTVKKTVTSSSSSYHTKASEPKSTTDCITSSYGVGPMDENGLPLFGIRALKKKATPVPPMDGEGTTVTGTIVTETLYAENGGPAVGKRSTTHYAGEEGGLKAITRTEKFDSTGAHSVEEVETIEGSGRTAKVVRKGSVKELTERFVHRESSGSLHQQQQQVQQDSRSYPKAGLILRSSAHSHSSRASTPATDGCSLGDEHEQVEEEDEEQQVEFRRGADAHTMTSSTSSTRQVRSFLNDTTKVTDVQDVLQRMSNADHVEESGDTAEDREARALLNKFLGASVLMSGVESLMAKPAGTTITTTTTTSTGPAARKRLSLVSKLSSTTTTKTHTVKSSGGSASSPTKPATVDNLDEIWDEAILKQLLESSTSYDDRRKIRARIRQIMAEKEACADIVAIVTADLQRERQLQQQSAATATAVAPTNGLPQGESLLLPLLQGLLLSSAVALVPPVEDSGTESGEDLRLLAAAAGAASGGSVVGSGGGAGRDAGRLGGGLTGILHEVSAALERLQLTLRAEPLGQGCAEVIHLDAEKRNALLALITRLQQGLLQPDKIGEVHGDTGSCGGGGVGDSYDDPRRPPTAAVAQRPSGQVEGSANGGERTANGNLDDSQTRPRAVGSSRFSAKRRTNRNSRHTVGVSREELADARRFIEEMVLMDGRQPQAECAPAPEKTYLLQKQHSLGTVLGSEPAPQGQPSAAKPAAPSSGSSSTTTPATAFAMKRPSQFVPKEMQNLHHTTLDKMSGTKHSAQAASATPVAPARTKPSKEKLLLLNRQSLSVDQALPPTSNGRVSPSGRQDSVAAKPIDLHKHKPAATVRPQQPLPAAVAAPEEPFKKPTQTAAQRALVKKYSFNDGSSTDEDEERRALRKPDEPKKTAEQMVLRNKITPTEAAAGQGGSLVINTVQKIVSRETKPTNEQVGRVAPRSTARQGQGHQHPHHHGPTQGRSRTPDSSLKADETLAKPVNKYTSKKLRMKRANTIDIPKNMLPNSASEGENDDDDDEVGAAGTKQSARKRTNAGAVGRGTAVKPQPPGAPPVEVPDFKPRTENDLKFMAFLQKQNQQPRQIWSNPVREHVGSNNWTNKFGHLKSNFEQPGDRRSRSELPPKYGAPKPSAMSFWKQAESSSIDEPTPMARPTTKQTTPVQSKGSSQPSPSSGVGQPGARTSTTPNRGKNAPGTYSQTVQPSAGSHPKGDNTADRSVVEGKLVLPKATGATGGGTVNQFSHASASAFKPIPKKLPTPTGQLEFKPIQHEPEIVRPIPARVTNATGLVKQIVATGFKETPEVKPEPMQVQLGLVRSLAAQGYQETPYVPLPKIERTPTHKVLNYNPRPDAASSIDPAPAAPWVGKRASDPASNRVASIAATKFTANPFGHNKQALPAQQPLTYQGSLKYAERPLAYQVSGMNGHAMAPYEKRPSLPDVSAIGSHLGTYTFTDYTHPESVSTFSLNRSDSLTNPENEPLVLTSSNSVFSPTTAVTRMVPPALQHQQQQASQISYLAVNVDQQSSSSHSPANPDEDDDLDDVYDYDDLDSVDSQEMRVVSKVMKAPQGQQATYSAPVRSTHLRAVNGHDGPDAGGRGSLIAQSLHSSLKKIKDKSPTPPKARTRYSQELSPAPITADAGHRAIPSLAQPPPQLEVTAPVPSHAIYNNVHAQYTHTRLADHHHQPLLARTKSSHNLTVPVTAQPLRPISSDKQRTVEAYFTGQSGVAGRQPAVSMAPSSSGYQMARTASSKNLVLRDKSGMAGQHHHAVRPVSYAMGHNMGYSSYNGGQAMSYAPQSAHFQQRNAPADYPAYKPHAHQQQPAQAPLGGGLLRSRTMPHIPLGSLALLDENNVEDAFEELMNQSFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG53</accession>
    <name>A0A084WG53_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP009806-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00017198</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG53"/>
    <dbReference type="STRING" id="74873.A0A084WG53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017198-RA">
        <property type="protein sequence ID" value="ASIC017198-PA"/>
        <property type="gene ID" value="ASIC017198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017198"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000033"/>
    <dbReference type="OMA" id="PHQTMAY"/>
    <dbReference type="OrthoDB" id="6022628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000094">
        <property type="entry name" value="Blast:Carbohydrate-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="717"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017198-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="942" mass="99360" checksum="2CF3952A9816DF39" modified="2014-10-29" version="1">MPTDTLFSTLAQYPFPDSREIARGAGRADFIQPSLGPLQPNLDDLMDLDLDFLNFPRLAPVPEEASDDLLKAIDYNYTLGSTNQLANTGSSIQEVAAGITSSGGSQQSNQVIASGSTSSAPSIQYSAKIYTQTLGPAGAASGAASLATQSSIAQQLSNAFDSYITDQLVGGGGGGNSQGPSLAAINIQPTPVQVQSQQQQQQSGSDELSRSLKFRKCSKHNYDPKYPPTPHQTMAYNMVSQPLMGQTAARTSNAMIGGNGGGSGSGSHPYGATIAGGFQNVPPNAAMLQMQGNVTSVVQSPSSQGGMLLHYNHSGLQGAPTTTNPVNLSNTTNTGNNGNGGGGGGGSSNSNIRSGGGGDASNPLMQSLTSKLLTHSQSLPVPTLPQPKTIPQPRSTSMPTAPNYNQMLAASQHSPPGSLHASQSGSSYKSYHAHQPQPYKIPSQTVGVGGSYASGVRAMRHSSPPHGTLLQPTAGSVTAGPLQQQQQGQPKRHPPHPTKEMFRSNSLPINATFPLPPKEGESFAMPRYQQSQKANAKLRTRSNSMIMKQQAGSANNHAMMGGGGCPTGSMGGGAGQQHMTPTLHTTSSEPMLNVTSSALLAQLLTTNSKWKDFCTFPCLLSFIFPFSHSFFTDASTLLSKQQSHSTSSTQPSPSSVLSFASSTGMSLSQQSLSPESAHDTDGPMSPIGVGSGGGGGGGGGSSSGGGAGSKFPRSDSQRRSGHIHAEQKRRYNIKNGFDTLHSLIPQLQQNPNAKLSKAAMLQKGADYIKQLRSERTSANDQMDSLRREIDQLNNSLNNLHTALPASGAPVSRQRTGRVKELYHQYVRQRTMDNWKFWIFGLIFEPLMTSYNQTVSVASMDEMYRTSQLWVDQHCSLVELRPAVSNQLRQLSTTTDVLSDPPSLLQEEVLKAISTNSNCLVPRAGSSKSGSRGSSAETSPHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGC6</accession>
    <name>A0A084WGC6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Beta-fructosidase, levanase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017382</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGC6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017382-RA">
        <property type="protein sequence ID" value="ASIC017382-PA"/>
        <property type="gene ID" value="ASIC017382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017382"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6389" checksum="A47E7192735D2F28" modified="2014-10-29" version="1">MFPCGFALGKRRTDGLATGSLILRDLLNISGTASSPSIAAEGDEEGLGSGCGLIGGEDGRLYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGY1</accession>
    <name>A0A084WGY1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008095-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017675</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023768">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023769">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGY1"/>
    <dbReference type="STRING" id="74873.A0A084WGY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017675-RA">
        <property type="protein sequence ID" value="ASIC017675-PA"/>
        <property type="gene ID" value="ASIC017675"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017675"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022721"/>
    <dbReference type="OMA" id="FPHCNAV"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000271">
        <property type="entry name" value="cilia- and flagella-associated protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="780"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="888"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="979"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017675-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1225" mass="140232" checksum="65C5354DBBE1B877" modified="2014-10-29" version="1">MEKTNRSKQISIVPKNAYGLRTDILGNVHFTLKQEIIYPVAGVLAIHDYTTNKQKFLRFPQNCHPERIVISPNRKFIAVAERTNDNKSMVNIYEIETLRKRKTLQLPPDCPNTQIGNICFTHDSRGVAVLSVEPDAFLSIFSFDKNDSLIIGRASNSSQQGQAIYLSCNPNDATIVAVGGFYMLKIMNRTDKGFGQIGTIKGDDLLITSMTWLSSEVLAAGTAETEIIFVESGELKIKQRADEIETVDLSGEGDPNLVTTPAEVAGLKHDHHDVLCLTQFEKGFLYAIHNVVHVFERETNYNFRKKSIIRIPITLYEEQLYKIENVAVNHEQDTIVVATKHSQLYIGMLIVPETLKISELVFQHLGEPLHISGIIGMAVCSWKPIVMTASRDLTIRVWNYETMKVELVKKYQIEIGVIALHPSGFFAAVGFIDLLRLLQIQLDDLKETKSFNLANCTQLQFSNQGHLLAAAHGKSITLICIFTFEIVQTLRGHNGAILSLSWSTDDAILASGGNDGAIYKWNVVTGERLEEVVQKGIHYRSLALTADAHSVYSITNTGLIREVAKSDIAREFKIPELTPLTDMALARSDAILFVGSVKGHLYNVQVPLVDTSSGNCTNFRFFNTKVTKICITYDDCTLITAADDGTLIVWNILNNEGKTARHAPELGHCSDVLIARQELIEKNDSISTLEMRIQQQSMEFQYKMKQGDAFHSEQMRDIHKDYCAAIENLKKKNIEMEQAHTEEFNLITASIAQAKEEHQKEMMDFEAQFHEKIILEYDKLSSLKSKMDSMREEYEVKLRRSAGCLQDTIESMEADQKRMLSEKQEIIDNMLKDMDRKRAEFDEYCRQVDVDNDRHKVELQLQYEKKLQEEEENSIKWRGEAGVLKKKFSTLSRESEAYRKEIETMQAQHGKFQQSIRQHQRDIEALRREVAERDGIIRDKDRKLFELGKKTAELDKYKQVLSMKITELRAQIEPKDREIKERKEFILEMEKKLDELQQHNKQYELQLQELRDKYYGIDLELRRERNKFRNAKAQYQRVCGEIYNVSGLIQRPEELKRCVKELCHRYGDDKELQKSLALDEDVQNEFLRQREYLERMTKSAKQKATGQRKDAGESLKLMKENMELLAELNKLRECLNEKQRACTRMEALLGLSSKAISPREAKEKLEKAVADRDAIEQQHREQVAKLEELIRTLSSENQTLRAELVAQNMRPKLPAASVATGAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHJ3</accession>
    <name>A0A084WHJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP012332-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018048</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHJ3"/>
    <dbReference type="STRING" id="74873.A0A084WHJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018048-RA">
        <property type="protein sequence ID" value="ASIC018048-PA"/>
        <property type="gene ID" value="ASIC018048"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018048"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021439"/>
    <dbReference type="OMA" id="FEHYRYY"/>
    <dbReference type="OrthoDB" id="8434295at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13273">
        <property type="entry name" value="PH_SWAP-70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057836">
        <property type="entry name" value="EF-hand_SWAP70_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057837">
        <property type="entry name" value="PH_SWAP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383:SF5">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14383">
        <property type="entry name" value="SWAP-70 RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25530">
        <property type="entry name" value="EF-hand_SWAP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="219"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018048-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="554" mass="65144" checksum="F3839AD48612019F" modified="2014-10-29" version="1">MATLLKNVTNSICHAFNALQQNRDCFVSKSKLKVLTANIATLLDLYGVERGLDHFRSTATLNFEHYRYYLAQEVFASVSNDLPLAALRNYETKIDEVCWLVCRMNFLTNDEYYTEEAIYQLFRIFCLVADLSSDPNDPDVFTVKIHPLEALIIIKHLLNSLGLNYDGDGKYDYLRTSDESLEFGELLEMLRFKNYDKVNDYRESICEAVGDMYQTLIEDVIKKGYLFRRGYVLPTFREYFFVLQPCELSYYKHPTDRDVCGTIVLDSKFMVKPSHSNSGKQEKVQRFTLVSGDRTYELGTLDHKTRLQWIAALQLAITYSTGREGFQRDTVNRRKQQRETEQRRRREEEQLRSQHLKKLEETHVQLEQEKLARLAAESQARQYEAVAREDSRRVAELEDVKLCLEKMLEDEIQAKRDEEIVRALQARVLAEEWEKREELEQLQAEQKSLLEQERQKRIEFEYRQQENEEKLLEAESMLRQLEEERKRLDRELKLARQKIQLSEDNKGIVEAKLQAMSPTYRTSAGEFMIRRTQSFVAADRPVLVAGTRSSHRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIH2</accession>
    <name>A0A084WIH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Exodeoxyribonuclease V subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018058</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018058-RA">
        <property type="protein sequence ID" value="ASIC018058-PA"/>
        <property type="gene ID" value="ASIC018058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018058"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018058-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11601" checksum="E735FF4AE6B978D2" modified="2014-10-29" version="1">MDLIRTKNWAVKKTGQHAYLLTTKSKTFAVSIGWSIGREVKIKANNWSTNHRSGRIGIESSKPNPGDKQEEGKRGVWGELLEKDRKDMLPIRSLGVDYFQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIK4</accession>
    <name>A0A084WIK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP011916-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018096</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023936">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIK4"/>
    <dbReference type="STRING" id="74873.A0A084WIK4"/>
    <dbReference type="ESTHER" id="9dipt-a0a084wik4">
        <property type="family name" value="Neuroligin"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC018096-RA">
        <property type="protein sequence ID" value="ASIC018096-PA"/>
        <property type="gene ID" value="ASIC018096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018096"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004236"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016959"/>
    <dbReference type="OMA" id="DHIPYIL"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000138">
        <property type="entry name" value="Neuroligin-1-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="742"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="65"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="931" mass="102074" checksum="F2E695E6FE72BE57" modified="2014-10-29" version="1">MRAHDGPKRSYRHTQPERQPEVNDSSARCVLRPSFCPVRATVWLGLLCCLGAAVGPVRAGPRYSSRIVETKSGAIRGVILELNSKHLEPVEVFKAVPYATPPTGSLRFEPPKKLPPWTGTKLADTFSNVCPQNFPDISNRTAVLLSMPKGRYQHLKRLQPLLANQSEDCLTLNIYVPGSGSRGLEAPYSIFFYVHGEAYDWGSGNPYDGSVLASSGHVIVVTVNFRLGILGFLKTRASLSPGSGGNLGLMDIILALRWVRENIGSFGGDPKRITIVGHDTGAALANLVLISKSGKGLVQRAILLSGSALSPWALIPDPDAVRLEVSQQMACHLVPGRNGRKPSTDDITDCLRDKPIEALMGVRLTSVRFMPSWGPFLPLEDSLDPEFAMEHSGEGFITSELMLGATTTESYNDFSASDIQYGLEEDQRNRLLRTYIRNAYTFHLNEIFSAVRNEYTDWDKPIQHPINIRDSTMEALSDGHTVAPIVKVAYLHARRGAKTYMFHFAYQSKESEYPQRLGSVRGEDLPYIFGLPLVQGGPGFPQNYSRQDMGVNEAVLNFVTNFCKTGDPNEAGHQQAGQAQSPPPVHPDYGTAKERTRFRQITWETYETTTQQYLSISTKPKMRTHYRGHKMALWLNLIPQLHRPGDPEVSMRHHHFREREPHYYAGSVRAESFSRPKSLYQNGLINDAQESRQESFGTECTPDPTMGEVLQEAGGVPGDTPGNILTDEEEEELLEKLANRHYYSYTAALGVTVGVGCLLLLLNMLIFAGIYYQRDRTKRKSQASQSSTSGTLTGGIGGSGATSGTSTSLSGSNGTPDESEIPLTTLPSPSPVKAKRSIEPPPSYATLPKRSGGTNQTGVHNQHHQHQHHLHQQVPACGGHGTGYGGAKETNLGSPSTASRSGASTLGRSSTGSFCDSSSRSRQQQFSQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ93</accession>
    <name>A0A084WJ93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009410-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018367</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023983">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ93"/>
    <dbReference type="STRING" id="74873.A0A084WJ93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018367-RA">
        <property type="protein sequence ID" value="ASIC018367-PA"/>
        <property type="gene ID" value="ASIC018367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018367"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018047"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19356" checksum="E54DB622FA3F7EE4" modified="2014-10-29" version="1">MSDVLIPRTSPGLSTTVGEKNLITANVRSCKYALSYCIYMTFVCTLFCVSLLWANYSIFAMASQSNSSSIEFTLHLEESFYGLNNRSEDFCGLNNLIEFTLHLEEGFYGLNNRSLATGYIILTIYMLPLMYLCAYTGTTKTLAIFNAIYCCHTAPRTIGLKVQHLNNRQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJS6</accession>
    <name>A0A084WJS6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007060-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018503</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJS6"/>
    <dbReference type="STRING" id="74873.A0A084WJS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018503-RA">
        <property type="protein sequence ID" value="ASIC018503-PA"/>
        <property type="gene ID" value="ASIC018503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018503"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022906"/>
    <dbReference type="OMA" id="NHMEALH"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784955" evidence="3">
        <location>
            <begin position="22"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="794" mass="89272" checksum="96999540B3D94111" modified="2014-10-29" version="1">MGFAKASILIVIFAFHTTCLANNVFECDEYQCQFKLKQTALSEDANSTKFQLTVEDGLVSVTFVQSVLFTIPASVFADGNGVKIDKLDASASNVLAIDSRTFANASALEYLDLQQNYITELQNNVFGNATKLISIELQNNKIADIGASSFKGLARLDKLQLSFNRLRSLPRKLFAGLRRLTELHLAHNSIVELPDRLFEDLGELKVLDLTYNDIKQLSGDVFIGLPQLKILELQHNRIAAVEENTFSLPNLTHLDLSNNRFTHLPKELFLHTVALLELELRNNSIDHLDVDLFDNLYDLTKLTLEHNKLRSLDGALFKNLGNLERLLLENNNLHRIVPGTFDNLKKLEVLDLINNGLTSIDGGLFRNLRSVTHLLLERNQIKNVTKASLDGLERLERFYFEQNKIKAIDSDVFCQHQLLRVLSLKGNKLTRVTPETFNCLPALNELDLSSNRLENISLSVESLRELDLSNNRLRKLSDDAFLKMDSLIRLTMDDNLLEVVPNTIAKLPNLEYLSLKNNNITSTALNGRAQELRELSLSYNVLVNISNNPLKTLDTNLFNKTTRLTTLILRNVNVTQLPSGIFDSLIDLVTLDLGGNQISSLPNGIFRKQYPLESISLERNAIEQLDPAVFEGVSRLKKIDLSHNKISTIHPQLFANLLQIDELNLGYNKFVTFDLTATALRELSVADSHVQRVKTDGINEQDALTYLDISNNNLTSLELDAFGKFSSLKIFVFGGNRFETFSISDLLAAFEDLESIGLEGTQWKCDFLRTLDTPMRASFIGEWLKNEGTGASCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKD5</accession>
    <name>A0A084WKD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018717</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018717-RA">
        <property type="protein sequence ID" value="ASIC018717-PA"/>
        <property type="gene ID" value="ASIC018717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018717"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018717-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8408" checksum="CF3E5E1229FB9B3F" modified="2014-10-29" version="1">MRSFSRTSERSLGVEHAAFPQSGQMGTVWTAAGLSSAECSLATTLYQRTPVPHPKSSASPFELHQSTALRVRWVGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLB9</accession>
    <name>A0A084WLB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019060</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect beta-1,3-glucan binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLB9"/>
    <dbReference type="STRING" id="74873.A0A084WLB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019060-RA">
        <property type="protein sequence ID" value="ASIC019060-PA"/>
        <property type="gene ID" value="ASIC019060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019060"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006961"/>
    <dbReference type="OMA" id="GPSGIMP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02179">
        <property type="entry name" value="GH16_beta_GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000235">
        <property type="entry name" value="Beta-1,3-glucan-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035806">
        <property type="entry name" value="GH16_GRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784938" evidence="7">
        <location>
            <begin position="20"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="10">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="9">
        <location>
            <begin position="146"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="663" mass="75244" checksum="18A2BFE846EE65AB" modified="2014-10-29" version="1">MKKLVQCLLVTLLGLQAIAYTIPEVRFEFPTNRGFRASIPDTEGLQMFAFHARLGKPFERFEEGDYSGDISVVGADGRWAFETNKPLLPNGIIIYYWVYVQFDNAGYWLTDRKYMVNKPKATAPPKTTTAKVTTPTTTTTTTTTTTTTTTTATPCGASLTTLNGGRSTCAGQLIFEDTFERSTFAPKWQHEVRIPLDTESAEFLSYQNLSENSYIAGGQLVIVPTLVTMGADYTDERIRTGELKLDGCTSPTDNPYECQRKAARSTILPPVVSAKLNTKNYFRFRYGRVEIRAKLPKGDWIFPQLLLQPFENFYGYADFASGQMWIAHILGNRMLVSADGKQIDGHRLRGGVLISNIASLREDFLRSNVNDDHFGDRFHVYGLLWRPDAISLTIDGFQYGTLRTNFRQHGHQRNLTQANLWNANASLAPFDREFYLSLGVGVGGVKDFPDRCLTGPSKLPKPWNNTSPKAEYFFYQTRNTWYRTWTEPELTVDYCLAECSLNVTRVLIDHQFRVEQARKVLLARTANDTDWAKTIGVAIDKCYRLTVVRPGLGFRTKCIRFTQHPCCLFLLQLNAFYLQDVAQNRISSQCLPISIRFLECAFGITYRVSGHGQMELVQHLNRPCSLSPQDCPAKHRIKWDDECYALVRAFNSCPFFFNKKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLI4</accession>
    <name>A0A084WLI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019134</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLI4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019134-RA">
        <property type="protein sequence ID" value="ASIC019134-PA"/>
        <property type="gene ID" value="ASIC019134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019134"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019134-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12326" checksum="9AD47A29EF0CA6AC" modified="2014-10-29" version="1">MGFVVGWWLEWYRTAGTDCIRPLGGYIVYGLENGTEPAQRDECNPTNPFAFRSQSKYPVMAWNRSCAKCNGLMLVRPACERPNGRTNARRTSVHGCTRTSVPPYGYGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLL1</accession>
    <name>A0A084WLL1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019163</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLL1"/>
    <dbReference type="STRING" id="74873.A0A084WLL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019163-RA">
        <property type="protein sequence ID" value="ASIC019163-PA"/>
        <property type="gene ID" value="ASIC019163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019163"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008418"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="409" mass="46853" checksum="2B71970278E338DF" modified="2014-10-29" version="1">MVLELLSNKQLLKSDFIRSTRKLVRICQLYGTVPWYLDLFEGGFLLREHQQGGLRLWCMQGLNMIYSIVIASGIFIATILQTSLDDWKMPFMTQMLYISEYIASNVVVLMVLIGCHYQCCYYQQFTEKLLAITARIASCGAAVDFQRIETTFNRLLLGVAMFFGSVLAVDLLYNDLLFWSFVRSSSVFCLSNIINVLGLIQYAYLLYFIFLFYSDVNRLLMSYTVHASRDKHFRARRRLLYETTVVSPSDGGVTLLYDYAHLVDRLRSIHLDLNELLEQVNNCFGVLIVCTTTASFVVLSLQLFCIYQATTVQAWYAQDTFLLVYNVLWIVLHAAKVLMVLYPSHLVQKERERTGPILYHFNPHEKDTALNNAMVGALTTYLVILIQFDTTLKQSQSAANASQKDGSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN77</accession>
    <name>A0A084WN77_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007445-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019755</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN77"/>
    <dbReference type="STRING" id="74873.A0A084WN77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019755-RA">
        <property type="protein sequence ID" value="ASIC019755-PA"/>
        <property type="gene ID" value="ASIC019755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019755"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006459"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014008"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016808"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019755-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131526" checksum="9EAC77AAE6CDA15E" modified="2014-10-29" version="1">MSSNLLSRVPRRLVNSATLSRPQSIRLCDSFLPLIWTVLLLHAQDSYIAVVDGALCLRDYPGFCTLAEMSPHQENWQTSFVEAIGAQYRNVVVKRVYLPVHFQMERFLETMAVYFNDCKFQHYHESIFPITHIVTFITIAVDHATKLQHLQLAPNEYLERLYIVDSAIESVPRTVANLKKLQFLGIDKALLRVLDLNLFCTLPYLRSVQFVDNRISLVLSTDPQNCASSLKDLDLKNNRLTNLNLAAFVPFVYLSRLILEGNGILSVFSTSRITLLHLSLLSLMGNKLSFFDTDQLFLPECGAIDLTNNLLKKVPTLSDKSVPNLEVLTLKGNQLSTVDLANFQKLQQLAHLDLSENLLTSVYASMPVHLPTLNQLGLGGNRLSSLSTQNWNFTNLANIILDRNLFDQVPTQILRNGVIQQLDMRSNPIRCILCCCLFWVIIYLDVPTTGQQCVSTFSGVCTISEISTAKNGWASSIRAASYPTIVVNKLLIPASPKALPAFIQIVSNITSTLEFVFYREKALLLVRQTPLGYLRINNAPFLEQLILEPNDYLFELTVYNGLIKYLPMTIRYIRNLEALSIQRMQLTQFNLNMFSDSQILTEVTVSNNMISELIVSSLTSALEFVFYQEKALLLARQTPLAYLRINNAPFLEQLILEPNDYLLELAVYNSSIKYLSLTVRYTQLTQFNLNMFSESQMLTEVTVSNNMISELVVTNQTVHIEFLAAVLCFCLFWVIIYLDVPTIGQECVPAVRGVCTFPQISTTKSGWASSIRTATYPTIVVNKLLIPASPKALPAFIQIVGNLAKNLEFMFYQEKILVLTRQTSLAYLSVNNCPFLEQLILEPNDYLLELSVYNGSIKYLPMTVRDIRNLKVLNVRYTQLTNLNLNVFSESQMLTEVTVNNNMIRNIVGTNRTVYIEFLAISNNRLTTVNMAFFKQIRNLTRLDLKNNQIVQIWSSEAVVLPMLSYFALDQNNLTSIQLNLVEIPKLAYLFLGHNKLTIFPRSLNKFPKLRTIDLHRNSLAFFDLTVLGTVPNLAMLDLQENQIASITTKTTIQHEAIEQLDFGNNGLKAVNFTGCSFPKLKYIDLGYNKVTTVVPNIFQQFPKAALYLTGINMSCSDLKGYTSEIYNLRLNVDTAWGSNVCSTRAHIQITNSKRACCLETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN86</accession>
    <name>A0A084WN86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019764</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019764-RA">
        <property type="protein sequence ID" value="ASIC019764-PA"/>
        <property type="gene ID" value="ASIC019764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019764"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8122" checksum="DADBEDDBCA8ABBDA" modified="2014-10-29" version="1">MQFAKPTEPRIVWALNDNDQRLGKEGKHRGEGSETECCRIDTIECWRLQEIGNHGSMEKPACTGPLRRLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNL7</accession>
    <name>A0A084WNL7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020002</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020002-RA">
        <property type="protein sequence ID" value="ASIC020002-PA"/>
        <property type="gene ID" value="ASIC020002"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020002"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020002-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8000" checksum="DDC9CBBF4FDB4081" modified="2014-10-29" version="1">MAVICGAGKSPGVVEYFTTAMGQLGLPEVPFTTMSPVWFPTLTLFRGGFALPGWDSIPGIFGDQFAFNRIMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNX0</accession>
    <name>A0A084WNX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP003603-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNX0"/>
    <dbReference type="STRING" id="74873.A0A084WNX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020100-RA">
        <property type="protein sequence ID" value="ASIC020100-PA"/>
        <property type="gene ID" value="ASIC020100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020100"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020717"/>
    <dbReference type="OMA" id="MHIVVPE"/>
    <dbReference type="OrthoDB" id="10059918at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000202">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF24">
        <property type="entry name" value="FIFE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020100-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="309" mass="33679" checksum="13D9E4F59BAE20F0" modified="2014-10-29" version="1">MAADDLPERDESLGYGMYPEAYASIKLLPKTNESHVAQTEVSTPSLNPIWNATITFQDVFSDNLLDRKIEIVLYDLLPHSEPIFLGECSVKLQKACLDDVAVWYRLEDPNRLRGSGGPTVGGRTLRRRSTVGGSQSSIDESIGSSFGRYGGSNDGSRFQRSISDDVDSLDEGRYLLHPNWSVSGGSRRGSTQSEIQMQTLEVHQIGKDYSKSLPGSRRSSFQDSKEQLAAGPPVHYSRRYSTGRAATGGTASTLEPPAHPVRKLSFGGTIGGLGSSGPSGGGSRSEFIRTMSLSRELDVKNRKKKRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQP7</accession>
    <name>A0A084WQP7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Collagen IV NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00020791</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025642">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WQP7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020791-RA">
        <property type="protein sequence ID" value="ASIC020791-PA"/>
        <property type="gene ID" value="ASIC020791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020791"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002310"/>
    <dbReference type="OMA" id="TCSNNES"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1541"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="743"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="968"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1187"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1271"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="554"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1380"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB52541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1764" mass="174156" checksum="EBD37763617C7A23" modified="2014-10-29" version="1">MYAVGQHMQQFWSDLSNTGGVGLFKRADDDHPRHTQPRIDPSYSIIDPASGPQGPPSKNCTSGGCCLPKCFAEKGNRGLPGPAGLKGGKGVRGFPGSEGLPGEKGSKGEPGPMGLMGPKGDRGRDGLPGYPGIPGTNGVPGNPGTPGLPGRDGCNGTDGLPGLPGLAGSPGPRGYAGSPGSKGDKGEPARHPENYNKGQKGEPGLEGLEGLPGPVGEPGVRGYPGTPGDKGVPGLPGAKGERGEKGECIKGAKGEKGAKGTEVYGLESPPSSTTGPKGDKGDRGEPGEPGRPGDKGQAGDRGQVGDRGHKGEKGLPGQPGPRGRDGNFGPVGLPGQKGDRGSEGLHGLKGSIGPKGDAGRDGYPGQPGIAGPPGAPGGGEGRPGAPGPKGPRGYEGPPGPKGMDGFEGEKGERGQMGPKGGQGLPGRPGPEGMPGDKGDKGEPGSVGMPGPMGLRGYPGQPGQDGLRGEPGQPGIGAPGPKGNPGMAGFPGLKGQKGERGFKGVMGVPGDAKEGRPGASGMPGRDGEKGEPGRPGLPGGKGERGQKGELGGRCTDCRPGLKGDKGERGYAGEPGRPGVSGAPGERGYPGVPGEDGPPGQRGEPGPKGEQGLIGPPGPSGEPGRDAEITLAQLKPIKGDKGNMGERGLQGVKGEKGYSGPVGPEGKPGLPGPKGEKGRPGEMGIDGTPGTPGNDGAPGRHGQTIKGEPGLKGNVGYTGDKGDKGYAGLKGEAGKCADIPQNIVDAIRGPPGAQGDKGAPGIQGERGDKGEMGLQGRTGLPGNAGPPGAPGPVGPRGLTGNRGEKGNTGPVGPPGSPGRDGMPGMPGVPGPKGSKGDPGLSMVGPPGPKGNTGFRGPKGDRGGMGDRGDPGLPGSVGYPGEKGDAGVPGQPGFPGEVGPKGEPGPAGPAGHTGAPGRPGMDGVKGLPGLKGDVGAPGVIGLPGQKGETGQAGNDGLKGFKGHKGMMGLPGVQGMRGPQGAKGEPGEKGDRGEIGVKGLPGPSGPPGLLGPKGDKGLSGLPGPTCLPGVSGEKGDKGYTGPEGPPGEPGAASEKGQKGEPGVPGLRGNDGLPGLAGPTGPKGDAGVPGYGRPGPQGEKGDVGLTGINGFPGLNGVKGDMGVPGFPGVKGDKGMTGLPGIPGAPCVDGLPGVEGPMGPRGYDGEKGFKGEPGRIGERGERGEKGDQGLTGPVGLVGLKGDRGLPGTPGPSATVTAIKGDKGEPGFPGAVGRPGKVGAPGLPGEMGLKGEAGFQGLPGLPGPPGLNGLPGMKGDMGPIGEKGDTCPVVKGEKGLPGRPGKTGRDGPPGLTGEKGDKGIAGLPGPTGPPGPPGPLGRQGEKGDRGDTGLIGRPGKDGFPGAPGQRGLPGPQGEKGDQGPPGFLGPKGDKGERGRDGMNGMNGPQGLKGERGLPGLEGVAGLPGMVGEKGDRGLPGMAGLSGPPGEKGQKGETPQLPPQRKGPPGPPGYNGQKGDKGLPGLAGPPGIPGAPGAPGEMGLRGFDGARGLQGLRGDVGLEGRPGRDGAPGLPGPKGEPGRDCESAPYWSGILVVRHSQTEDIPMCEPGHLKLWDGYSLLYVDGNDFPHNQDLGSAGSCVRKFSTLPILSCGQNNVCNYASRNDRTFWLSTTAPIPMMPVSENEMRPYISRCAVCEAPANVIAVHSQSLHIPNCPNGWESMWIGYSFLMHTAVGHGGGGQSLSGSGSCLEDFRATPFIECNGGKGHCHYYETQTSFWMATIEDHQQFQRPEQQTIKAGNLLSRVSRCQVCIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQW1</accession>
    <name>A0A084WQW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003939-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00020854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="KE525400">
        <property type="protein sequence ID" value="KFB52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A084WQW1"/>
    <dbReference type="STRING" id="74873.A0A084WQW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020854-RA">
        <property type="protein sequence ID" value="ASIC020854-PA"/>
        <property type="gene ID" value="ASIC020854"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020854"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015011"/>
    <dbReference type="OMA" id="GGIDFCA"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020854-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="18037" checksum="AEB43A775459848E" modified="2014-10-29" version="1">MVLDINFSRYDNTTPFGFKLVGGADFDVPLTVVKILPGSIAEAAGMHMGDVVVRINDIPTSDMSYYDAHQLLACAGNQFVLGILRAREVTPSQRLIKEKTPSGEVEYINTSPKPFWTPNTMTSPSLGLSREGHEEPEVPAAPITDEQIAEVLSGEAEVLKQHNVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRG7</accession>
    <name>A0A084WRG7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00021081</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRG7"/>
    <dbReference type="STRING" id="74873.A0A084WRG7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021081-RA">
        <property type="protein sequence ID" value="ASIC021081-PA"/>
        <property type="gene ID" value="ASIC021081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021081"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013163"/>
    <dbReference type="OMA" id="RLDEGYH"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000144">
        <property type="entry name" value="Chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785136" description="chitinase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="505"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021081-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="573" mass="64676" checksum="D726547E3F08007A" modified="2014-10-29" version="1">MLGRSRVVVLCLLAVLPLLAAQGQKARIVCYFSNWAIYRPDVGRYTIDDIPAEMCTHIIYSFIGVDDSNYQVLVIDPEVDLEQSGFRNFTDLRQKYPHAKYQIAVGGWAEGGKKYSEMVAQKERRQSFIASVVQFMKVYNFDGFDLDWEYPGAADRGGSFGDKNTFFYFVEELRRAFDREGRGWEITMAVPVANFRLQEGYHVPELCENLDAIHCMTYDLRGNWAGFADVHSPLYKRPHDQWAYEKLNVNDGVQLWVNYGCPPNKLVVGVPFYGRTFTLSASTTNPTLGSYINKEAGGGDPGPYTNATGFLAYYEICTEVQDMEKGWTTKWDDVGLCPYAYKGTQFVGYEDVESLEHKMNWIKQKGYAGAMTWAIDMDDFHGLCGPENALMKVLYDGMKDYVVPEPTITTTPRPEWNRPPSTVATEDDGRPSMSPSKRPATTTTTARPRPTTTTAAPIPTTTRRTTTRTTTRKPVTILPPEPEDSGEDREPEPAPASPEREDESEIDCSGYKDFVPSADCTRYYRCVHGQPVEFTCKPGTVFHTALNVCDWPENADRIECRTKAKLLEDLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRY4</accession>
    <name>A0A084WRY4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRY4"/>
    <dbReference type="STRING" id="74873.A0A084WRY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021268-RA">
        <property type="protein sequence ID" value="ASIC021268-PA"/>
        <property type="gene ID" value="ASIC021268"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021268"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018431"/>
    <dbReference type="OMA" id="HTCLSRK"/>
    <dbReference type="OrthoDB" id="9991628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF1">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021268-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11329" checksum="5D233B0D135D73C6" modified="2014-10-29" version="1">MADGLLLGDTCQHDMDCSDSVKGSYCTLEGVCECSPFYVRLNESTCLPSQLLESECSLSEQCSMRVANSSCIEGRCQCDGGFLQFRKHTCLSRKSHTESSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSH7</accession>
    <name>A0A084WSH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP002090-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00021473</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSH7"/>
    <dbReference type="STRING" id="74873.A0A084WSH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021473-RA">
        <property type="protein sequence ID" value="ASIC021473-PA"/>
        <property type="gene ID" value="ASIC021473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021473"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785167" evidence="4">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB53171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="12723" checksum="FC8C75ABAF97490F" modified="2014-10-29" version="1">MKAFGRLTDGRQHERQLTAVFLLLALWLTGGRMSPSASASAPALAGSAALTNITYSNSVVKTKYGPLRGIVFRASPVVVEGFLGVPYASPPIGSFKVSTPRSPPAGAGIQQTDGTLPRAASIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSI6</accession>
    <name>A0A084WSI6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021484</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021484-RA">
        <property type="protein sequence ID" value="ASIC021484-PA"/>
        <property type="gene ID" value="ASIC021484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021484"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785240" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13061" checksum="3EEEB62B7B384EDB" modified="2014-10-29" version="1">MRSFTVVAVLALSFCYVYAADEAPAKEAEAEGGKTYKRLIPADVLRGIGNRFVTFRYLRCSGHIVAYVGPSTENGLHLMHWALVRASVGTFRCCHRCSSTKAISWPITEGLTSCATLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTB4</accession>
    <name>A0A084WTB4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021964</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTB4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021964-RA">
        <property type="protein sequence ID" value="ASIC021964-PA"/>
        <property type="gene ID" value="ASIC021964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021964"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021964-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12811" checksum="02178986F1B8B4FF" modified="2014-10-29" version="1">MRFLSDIRFPIAHRRCSPTIQPMGIYKRCTRGTTSSLLGTIFVAHFNFQTGSDPTEPASDRVVPHHNQTLVHNGSSMRRKGNVPKLTENYDLGNDDDQNAWSASNMHRVLQGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTN4</accession>
    <name>A0A084WTN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021813</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021813-RA">
        <property type="protein sequence ID" value="ASIC021813-PA"/>
        <property type="gene ID" value="ASIC021813"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021813"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021813-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="26200" checksum="B7CF3B293145E8F0" modified="2014-10-29" version="1">MASGTCLREPEDLVQYAMPRANRIVSGKAGTFRLRRFGADRAPSRLGTCPHRNADDCRNDDSMEQPLALAFGTLVTNMATATGRRTKEGVRSIDASSLCWQQHVPVELVFWPIVFHRRGFVDGKEARRSQKTDREKATMITQWAHYGIWQSEMEVTFELCAISTIPDEPGVASSSDRPHAKSSMNDRWVTTAGRCSMTREEVVFATSLIGFLPCTTIPQNNPSMSNFNRLVQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUW3</accession>
    <name>A0A084WUW3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022261</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB54007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022261-RA">
        <property type="protein sequence ID" value="ASIC022261-PA"/>
        <property type="gene ID" value="ASIC022261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022261"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB54007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9515" checksum="74DF07AA264953D0" modified="2014-10-29" version="1">MQRTNHLKTSPDNAHHRRKPANPNGDSCPSDRRYRQFSPAFNAVTARFGHHSSLLKPAASSGAGGKECFDPTWQQRGVLLAGTKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB23</accession>
    <name>A0A084VB23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001114</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524256">
        <property type="protein sequence ID" value="KFB35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001114-RA">
        <property type="protein sequence ID" value="ASIC001114-PA"/>
        <property type="gene ID" value="ASIC001114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001114"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="11007" checksum="587DC94A1A806F37" modified="2014-10-29" version="1">MSNPPPIRFFLSLPSAASYHTAAYDAAHGTKYAYTGFYPAGYGGFGTAGYGTAFAAPATYSKIVHPATSTYTKVIQTYPSATVGVVSAGAAAPVVSGYGGVGSLGGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC92</accession>
    <name>A0A084VC92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005610-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002429</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524589">
        <property type="protein sequence ID" value="KFB35586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC92"/>
    <dbReference type="STRING" id="74873.A0A084VC92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002429-RA">
        <property type="protein sequence ID" value="ASIC002429-PA"/>
        <property type="gene ID" value="ASIC002429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002429"/>
    <dbReference type="OMA" id="FHIHKRQ"/>
    <dbReference type="OrthoDB" id="7765377at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="19992" checksum="928CD7535D8DE93D" modified="2014-10-29" version="1">MRTVYTVYFLLAASFFAGIVIAGVFHIHKRQAQASVQVEPELAVRSKRHIVQILRGGFSGSGASANAAVQDVGGVGGFSGSNAAANSLSQNIGGFGFSGSNANANAFGQSFGPGGFGSSAANAQAQSFQSDGPLGSFGASASNAASQGFSAGPGGLSGSAGFSGSQAYKLPGNRQISLSYSNGFSLANGQPSLSNGFSVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCJ2</accession>
    <name>A0A084VCJ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Speedy protein 1-A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002578</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010768">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010769">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01010770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524613">
        <property type="protein sequence ID" value="KFB35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCJ2"/>
    <dbReference type="STRING" id="74873.A0A084VCJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002578-RA">
        <property type="protein sequence ID" value="ASIC002578-PA"/>
        <property type="gene ID" value="ASIC002578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002578"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008954"/>
    <dbReference type="OrthoDB" id="10049357at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="28936" checksum="07886B17BD6A0767" modified="2014-10-29" version="1">MVLSGGVGAEIDARNSLQHGRGSFSPAATESGLSPDHRGDPSSMGEAANDAPSAAATSGPSPKLHSGHPPSITVPAARTVGMSPEETVDERPTAHDTTTSVTTPATSPARQKDDFARRCELLRMSIKLQQTQLELMMLEEAGSVSSLGKAEEWLCATDRCGTGYSGKNGAEIFASTTENPLPTNSAEHSPRVFGMAARDGGWHELAEGKRVLLTQIQRDGYPTEIRVLKSSAKRKHTWGQLIEKNSPLYKQTPVLDNRGILRVGGAFLHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCT5</accession>
    <name>A0A084VCT5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002684</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002684-RA">
        <property type="protein sequence ID" value="ASIC002684-PA"/>
        <property type="gene ID" value="ASIC002684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002684"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12008" checksum="9401258BAD11C3A4" modified="2014-10-29" version="1">MAITRPAGGIGEKLRARMVLMEIMFNVIVTFHFTPERRRWLAVYGAWKDIFLPALQEGSESFHYFYDPSRTRQVKRKASSGPRASAGAKRLPPELWIATLASEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDT7</accession>
    <name>A0A084VDT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003180</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524721">
        <property type="protein sequence ID" value="KFB36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003180-RA">
        <property type="protein sequence ID" value="ASIC003180-PA"/>
        <property type="gene ID" value="ASIC003180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003180"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="8785" checksum="8369ADEA5791796F" modified="2014-10-29" version="1">MAECIYCSSFVVHLETPERNSTSVSPNSNSASKVQTQRKHDSYPKPAPNGLPPKHVSSTEPVALLIFICGSVGNGRDDEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDX0</accession>
    <name>A0A084VDX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003227</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011845">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524726">
        <property type="protein sequence ID" value="KFB36164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003227-RA">
        <property type="protein sequence ID" value="ASIC003227-PA"/>
        <property type="gene ID" value="ASIC003227"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003227"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004967"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003227-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="31675" checksum="6D1ABD21E461C148" modified="2014-10-29" version="1">MAPEYRCVHCKNEWHETNLCPVYKCQKLEFKKAQFQRADRMYSSALKGDLPSDDVLSLLEEVPSINLLAPVVFSYCSAKIAGYFVLHVCFRPEPVLSAYLPLSCYTEPFFLSSTSFTVFSSILRAACWTMAPLCFACANDLAPDHESMRCAICEASFHDACTRIPQDLLASVKLYSDLHWSPGCTKALENPRSKALKDVGLKAGFHSALGALVESLKEAIIPPLTSELHALAKASASHSTFTGPTVTAGCTYHFSPTPQLHRPSSYATIASHSNAPSNVTIARALHRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDZ4</accession>
    <name>A0A084VDZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00003258</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524742">
        <property type="protein sequence ID" value="KFB36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003258-RA">
        <property type="protein sequence ID" value="ASIC003258-PA"/>
        <property type="gene ID" value="ASIC003258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003258"/>
    <dbReference type="OrthoDB" id="7743132at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783394" evidence="2">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003258-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12143" checksum="9C33B8DC9FCBDEF3" modified="2014-10-29" version="1">MIFYRSLLVVLGLLAVAGWATSEQTGSEQAGALDDGEYNPKCRPIEEFEQDQPKDGRVKREEPVANVGETDGEIVAQPGYVVPANRRRLCLGRRRKFTEGCGPPARVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFI4</accession>
    <name>A0A084VFI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003896</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012411">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524791">
        <property type="protein sequence ID" value="KFB36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFI4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003896-RA">
        <property type="protein sequence ID" value="ASIC003896-PA"/>
        <property type="gene ID" value="ASIC003896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003896"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003896-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7756" checksum="40D71B2BCC758A18" modified="2014-10-29" version="1">MNSFRSCSSCSSCWQPSCSPLVPGGTYRKTLSWSTARRRGLRDCCFLRRRQRAAVCLVGTPNTTRVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFU9</accession>
    <name>A0A084VFU9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004010</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012487">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524796">
        <property type="protein sequence ID" value="KFB36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VFU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004010-RA">
        <property type="protein sequence ID" value="ASIC004010-PA"/>
        <property type="gene ID" value="ASIC004010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004010"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008929"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004010-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="17253" checksum="ADCD8744E0372B59" modified="2014-10-29" version="1">MSSWKKAAKSNQKVHRERAQPASRQHLGILEKKKDYKLRANDQHKKDATLKLLRKRAMNKTRRVHHHMINSKNEGXXXXXXXKDTGAHLVKAGGPGLEHGEQGVPAEFNVWTREAGGGTLAISVEGPSKAEIEFKDRKDGSCDVSYVVSEPGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGT3</accession>
    <name>A0A084VGT3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524839">
        <property type="protein sequence ID" value="KFB37177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGT3"/>
    <dbReference type="STRING" id="74873.A0A084VGT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004408-RA">
        <property type="protein sequence ID" value="ASIC004408-PA"/>
        <property type="gene ID" value="ASIC004408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004408"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013884"/>
    <dbReference type="OMA" id="ANKRTIT"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="172"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="380" mass="43137" checksum="E4FC2D1378E40251" modified="2014-10-29" version="1">MSNANVTNYLAEQKKSSNKELADEWTQIEELYNEKLWNELTIKLDTFVKHSALQNEEALLALYHNFIASFETKINPYGLVEILTVVISFISDKKEAIAFLEKLKDKVKVCDQAVWMCKVLQGQIHLEHLNQLDETKKIIEDLKDILEEAGNVTPVHGKYYMLAANYYRLVGQHSDYYRCGLQFLGCSIDTYPKDQWAQQAFCLGLAALLGEGIYNIGELLAHPILESLNGTDNEWLVELLRAFNSGDIVKFEQMKPKWSAIADLAAQEVKLRQKISLLCLMEMTFKRPANKRTITFDEIAREAKLPIKEVEILIMKALAQGLVKGAIDEVAGVVNMTWVQPRVLDRKQVAGMASTLDTWMASITSMEKLIESRASEILTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHG5</accession>
    <name>A0A084VHG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP002004-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00004540</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHG5"/>
    <dbReference type="STRING" id="74873.A0A084VHG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004540-RA">
        <property type="protein sequence ID" value="ASIC004540-PA"/>
        <property type="gene ID" value="ASIC004540"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004540"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008263"/>
    <dbReference type="OMA" id="ERFNIMN"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="644"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="846"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004540-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="902" mass="103030" checksum="279F66B66CD76929" modified="2014-10-29" version="1">MLPARVKDEPVSDSSFIDDRQSRSIEEMLEAMQEETEENPMRSTPFSADQAIPEHDENSFYNVKSTARQTLYMRTGETNIVIEPKLASQVNNASNITFDRVMLNRADVWHQVMVHHDGLCEKQKILEMLFSTFPLYDLFPVAYRRHANIDFFLVRMCPQAIGKLFDDGLKLKSGQLELAVSIRLGAAKFQTGQIFPRTMIAEAVKERCKNAQLYGMVNVLNLDNFAAHPQLEELCISLSNRSQFEVVCSAISQCLNNMARINNLRLANNGIFHTTPLSALKTSHLVSLDVSYNRIKHPSAFRTLREVPLLELYVKGNPLTDVPDYEGILREFFPSLLKLDALVTVSTSIPAYVNSDDEEEVEMSSPGVVLTDADLNAVAFKKYQLTPHWHLVTVHHNGICGKQEILDALFHQLGKLSFFPCYYKTYSKKDEFLVQNCYEALLFLVQQQLKLPVPSVNAVLKLSVAMNVAEAADNHVRPLRKLDDFVQKRFEENCLNLCSMQEGLNEYKYVDFSAKSPRILGYILEVAGKKFSHSCFILRLRNNDLQNCDALGNIGKLTRLVSLDLRFNSLSTITDLNGIPRNFIEELFLDHNPLCGTISSGVEYTRKIKRYFHNLKRLDGRPLIADGSFTFQQNYICTMEAHKFAEAFLKHYFSLYDSFQRLELQELYHPKAQFSMTCSFDVNESAQLNSHQQRQVSYIGHSRNLLEFKGRLDLSFAALIVGNERIAYVLTTFPKTEFDFLSFRIDVPIFTPERVLIIVHGRLKEESEARLGESCSLGFTRTFYIQPCGMGTGLFSKAVEYKICNDMLHLHNLTFESQNFLDTRAAEAKETSNTSELTTLNGDDRNDRENALTIFKQLTQLNRQWCVRCLEESSWNLMLAMNIFLKLYESGHIPKLAFTDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHK3</accession>
    <name>A0A084VHK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004582</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004582-RA">
        <property type="protein sequence ID" value="ASIC004582-PA"/>
        <property type="gene ID" value="ASIC004582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004582"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004582-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9486" checksum="B5872FA2372BC1A5" modified="2014-10-29" version="1">MQSFGTESGMKGIPPPQAWVVSGRRFALSTIAMKGESTNPTLTPLDKRKHGRSQPNRGHQRTRKRKRCGRKEVDGHGNEYLGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI59</accession>
    <name>A0A084VI59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Putative tachykinin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00004909</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524850">
        <property type="protein sequence ID" value="KFB37653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI59"/>
    <dbReference type="STRING" id="74873.A0A084VI59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004909-RA">
        <property type="protein sequence ID" value="ASIC004909-PA"/>
        <property type="gene ID" value="ASIC004909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004909"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005738"/>
    <dbReference type="OMA" id="CLYANSC"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="189" mass="21440" checksum="C44348CBEA4A1CEE" modified="2014-10-29" version="1">MDFFSILPLWRLIVWNVLFAGIVITATVGNLIVVWIVLSHKRMRTVTNYFLVNLSIADAMVSTLNVTFSYTYMLYLDWPFGTMYCKISQFVAILSICASVFTLMAIAIDSRGRRQYKDDCDNDCDDEDDCLSARLRSVGKSTASQRASPSHHGNGPLPARESSHPLSSPPRQRRDRKRRECRPGLDRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJC0</accession>
    <name>A0A084VJC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524866">
        <property type="protein sequence ID" value="KFB38064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005335-RA">
        <property type="protein sequence ID" value="ASIC005335-PA"/>
        <property type="gene ID" value="ASIC005335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005335"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007384"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="30075" checksum="EB9D2FC0423BB7B3" modified="2014-10-29" version="1">MKFTNATVSSTPEGSGSFVSPYASFSKAKVQVRQRTPVSSPPRAQILPAAGYHHQDQQFSHAGGSMRMAPNSTIVARSSAISVAGGPSNIYTTPRIHSVQSHATGFDTHHSLYSNSVNGGGGSKSSATTTVSSQAQRRKQLQTSPTSIATRDTTSAGDFSSEARLMLASTSVSNGNLGRPLITTAPLASTMPTITLTPTGGRVGNPTTTSTPVSRSNAPSVWNQIVVQSASGASTGESFFDPSAFRIGTLQHPAAILGCVPNASGTSSKNGSDVGNTTGSSPNTTTVRRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJJ9</accession>
    <name>A0A084VJJ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FBN18 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005433</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013671">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524878">
        <property type="protein sequence ID" value="KFB38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJJ9"/>
    <dbReference type="STRING" id="74873.A0A084VJJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005433-RA">
        <property type="protein sequence ID" value="ASIC005433-PA"/>
        <property type="gene ID" value="ASIC005433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005433"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017988"/>
    <dbReference type="OMA" id="NCAIAHK"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14501" checksum="237AA86AA6F4D7A8" modified="2014-10-29" version="1">MYKYGFGDVSGEFWLGLEKLHAMTRHGRHELLVLLEDFEGNSKYALYDDFTVGSEAEKYKLTVGKCAGSAGNSLARHNGMKFSTMDQNNYPVPGKQNCAIAHKGAWWFEKCYHSVEVQMNDAIKQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJQ4</accession>
    <name>A0A084VJQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013174-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005550</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJQ4"/>
    <dbReference type="STRING" id="74873.A0A084VJQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005550-RA">
        <property type="protein sequence ID" value="ASIC005550-PA"/>
        <property type="gene ID" value="ASIC005550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005550"/>
    <dbReference type="OMA" id="LNTYFCA"/>
    <dbReference type="OrthoDB" id="6234541at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22816">
        <property type="entry name" value="TMEM203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005550-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="17364" checksum="9265EA85C4065616" modified="2014-10-29" version="1">MSEEVEIKTYFKLVDVVKWIGITQFEILVNLLAFLVFTIMLSLKASSGELAGPLTANEWLLLFSPLFCGDFCNAYFCIIVGIRMYLHTKHRQAMHRLVWSIPFLLMTSGFKYLVCMKLSGQIQLEYSEVFSPIFVLLQMIAVKACQYNQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKG2</accession>
    <name>A0A084VKG2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011225-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00005855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC005855-PA"/>
        <property type="gene ID" value="ASIC005855"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS023565"/>
    <dbReference type="OMA" id="MNINGWL"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
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    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
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        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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            <end position="273"/>
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            <begin position="95"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38456.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005855-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="273" mass="31510" checksum="D025FE0B3D7B5815" modified="2014-10-29" version="1">MNINGWLVLLFCGVISYGQLTMAVERFESERFMKKMGYLQAKLHAVEEDMKTTMDNSLKERKEASGVEKLDPTYETNVEETYDFSTKEIRRKARSTEEEVQSVQASEEGRQVSSCRQAPNKSGKYMIQIGENTTPFEVLCEQNTRFGGGWTVIQHRFNGTVDFFRNWTEYRDGFGDLEGEFWLGLEHLHLLTNNRPHELLIEIKDFKCKTGYARYSEFEIGSETDQFKLTKLGRYSGTAGNSMENNKGFKFTTFDRANDNLEVPVNDDLPVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL96</accession>
    <name>A0A084VL96_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004132-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL96"/>
    <dbReference type="STRING" id="74873.A0A084VL96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006139-RA">
        <property type="protein sequence ID" value="ASIC006139-PA"/>
        <property type="gene ID" value="ASIC006139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006139"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005161"/>
    <dbReference type="OMA" id="VAQNDER"/>
    <dbReference type="OrthoDB" id="8197686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF24">
        <property type="entry name" value="OSIRIS 10B"/>
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        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
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        <location>
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        <location>
            <begin position="163"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006139-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="474" mass="52092" checksum="537485A09FD1085D" modified="2014-10-29" version="1">MAQRQMLWDMGIIYPGLKLKLGPTLGAPGVLEFVLDPAVAQNDERSLFEEKSTARILTKSFVVPFLLGLKFNLATLLPLVFGGLILLSKKALILGKIALFLSGMFGYGSLLTPAIAGGFGGFGGYGGYGHGFGGHGAGGYGFGSKPFRYNNPLADNPDFDSHHHQHHHHSSNHHGDYQHGVAADSDHGSSGYYKKKDKFLNLDERIEPQTASSLVDKFYEYEKQQMLKDRTARLFERKFYEKEHQPQSGTGGCFDSGQLVACARGEVVRLVERAIDSNVTLRVTPFLTIRKNPEWPGRVAGRETAVSDQSSSSWLGLFTKLREFLLSRVFQFSLVDAEGRWLLAEVDEGRGKKHKNKQGGMFSMALMALMAMIAQVILGKVAVLAAVALIMAKIALVFSTLNGLKKSNGAGAGHGAEHVVYDHPSHGGGGGGGWQRSIHPRTPYERYPSYDDQNDLPYRKRRPNYDYQDDLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLR5</accession>
    <name>A0A084VLR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP000452-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00006229</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLR5"/>
    <dbReference type="STRING" id="74873.A0A084VLR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006229-RA">
        <property type="protein sequence ID" value="ASIC006229-PA"/>
        <property type="gene ID" value="ASIC006229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006229"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010483"/>
    <dbReference type="OMA" id="CNSMPIL"/>
    <dbReference type="OrthoDB" id="5987010at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000017">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="637"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="845"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110134" checksum="230E5094A336DCAD" modified="2014-10-29" version="1">MYCSNENKPPNQGALGDTQSAAAMRPFHPHGLYADKDPELHFWEGSHGTNQNTTPVSTVLHSPEPTALDSEPKMRFQKRHQIQVGRSPVGSGGHNESSDSTTASSPVLLHAMASYGFEQCHHPSNSIAVGAGGGGSLLPVAPPYSTQSILSDGEIVVFDDIEANWPSAGGNGPEMSIYINSAAQMAQGKESSTERCSKAQTVIGGLTIAEYEGSPRRFGTTASHSAYSAPDGMISFSKSGSGNLPRPGFPKRVSSSSLDRDAQEDEKPTLIELDKCSDEFKFYDKPSISCNESERNAYDLDTKYYYRQQTAVDGEDFSTGPGNRRKSQHSTTLSPEADSGRATCGVDFGATPSYSTKDYGSRGKYGNAKPIGKEILSEPCVEYEQMCNSMPILEDGLSSGHTSDSEGNAIAGVGNGSSSNVYEPQKADDLLTGIGNALSQDSRYQHHQQHYHQTQTASVMNGYNSECLASNIQEALNDIKSTLQNTKILPTHGRQDLHHGEELGKSEDASPVWVLRSTEREPENDSAMGPDGGGPVRPGSTIEADEETDTDLETDRLLGHQQNIGEINYFENHVNIHVVSPCSSTLAKMKRYHTAIRADNETYSPSDVQLESLPEIDSKGRHKTREGLLDPAVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKAPAGESQPSTEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGQLVVLMARRRFAGSSGGGNTGAAGGGDGGAATSSGAPDAAAEPGAESPGRKRTSSSSGEVGAKVGANRTPKMICHVFESEEAQFIAQSIGQAFQVAYMEFLKANGIEDHSFMKEMDYQEKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLASSGAAARCGQLNIGDQIIAINGLSLVGLPLSTCQGYIKNTKNQTVVKFTVVPCAPVVEVKIKRPNTKYQLGFSVQNGVICSLLRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSIGEILMKTMPTSMFRLLTGQENPVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM88</accession>
    <name>A0A084VM88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19">TRPgamma cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00006407</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell projection</location>
            <location evidence="14">Rhabdomere membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM88"/>
    <dbReference type="STRING" id="74873.A0A084VM88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006407-RA">
        <property type="protein sequence ID" value="ASIC006407-PA"/>
        <property type="gene ID" value="ASIC006407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006407"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022325"/>
    <dbReference type="OMA" id="EVFNINC"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033583">
        <property type="term" value="C:rhabdomere membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0844">Vision</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="17">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB39082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="312" mass="35507" checksum="ED2743139D39F000" modified="2014-10-29" version="1">MEEENVVRPHQEIAALSLEEKKYLLAVERGDVATTRRILEKAEAESHININCVDPLGRSALLMAIDNENLEMVELLINHRVDTKDALLHAISEEFVEAVEVLLDHEDSSHKTGDPHSWEALPPDTATFTPDITPLILAAHRDNYEIIKILLDRGATLPMPHDVRCGCDDCVTSRQEDSLRHSRSRINAYRALASPSLVALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRRQCQDFATALLDHTRSSHELEVLLNHDPTGPAFEHGDRMHLNRLKLAVKLRQKKVGRRASWPAKHPKHISASIFMTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNH1</accession>
    <name>A0A084VNH1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014752">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNH1"/>
    <dbReference type="STRING" id="74873.A0A084VNH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006856-RA">
        <property type="protein sequence ID" value="ASIC006856-PA"/>
        <property type="gene ID" value="ASIC006856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006856"/>
    <dbReference type="OMA" id="ICNCSHE"/>
    <dbReference type="OrthoDB" id="7763238at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="331" mass="37391" checksum="F01D90B06DEBEA3F" modified="2014-10-29" version="1">MSEDSGSDSYDTGSEATKPLDFFVTRRKKEKMVKDDASEAEAAILRGELAAKMAEIEKLQKQLARASSSGESSSSREQHVEMRRPDFRELRELVTKFDPKQATCLSAEEWVAEIEDTAAHYGWDGPTRLHCARLNLEGSAKLWWSAVQRETTTWTLFTEKLVKAYPSSRDAIFYHAEMTKRSKTRDETIEEYVYSQVALGKRAGFNESVIVKYIIAGLGDFLSKSKVQLGGKIESIEELISQLKWMEGLKDTKTETVPVRVTEKKQEKVALCYRCGQPGHRAAICSTGGERTCYNCGVSGHLARIVLSRRHQKPDHLECRPWTKPTPLYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNQ9</accession>
    <name>A0A084VNQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator TetR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007042</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524991">
        <property type="protein sequence ID" value="KFB39603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007042-RA">
        <property type="protein sequence ID" value="ASIC007042-PA"/>
        <property type="gene ID" value="ASIC007042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007042"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8424" checksum="8DC2266D939BCA1F" modified="2014-10-29" version="1">MRLINRTTSIDTSEPALRRTLATTTGCCPGYRLQSPVLQPYEPYLHDLFDCPNMPLLMPAIRSPATPDNGGEAFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPX8</accession>
    <name>A0A084VPX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007480</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007480-RA">
        <property type="protein sequence ID" value="ASIC007480-PA"/>
        <property type="gene ID" value="ASIC007480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007480"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="7394" checksum="5942FAD3E6AAE569" modified="2014-10-29" version="1">MYCNVDKSQSTASGSAGSGSVPSVGGNVMMSGVLGLSGSMGGGSVGGGVGGGGGGGGGGGMVGIGSGNGNTVPPNNTKSAKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRI7</accession>
    <name>A0A084VRI7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Inter-alpha-trypsin inhibitor heavy chain H3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008084</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015683">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525027">
        <property type="protein sequence ID" value="KFB40581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRI7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008084-RA">
        <property type="protein sequence ID" value="ASIC008084-PA"/>
        <property type="gene ID" value="ASIC008084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008084"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9633" checksum="67F277296CFC6DC9" modified="2014-10-29" version="1">MEKLGIRNSIPVDDENDSQNMPPNTKAPHSLNGYLSPPFRRTSGSCRTSTSSFRIAGAQVEVISHFCTFRKSPNETLCSHLPQKSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRK4</accession>
    <name>A0A084VRK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008135-RA">
        <property type="protein sequence ID" value="ASIC008135-PA"/>
        <property type="gene ID" value="ASIC008135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008135"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14539" checksum="FA8F4B181D9A95D8" modified="2014-10-29" version="1">MLPIVKQATRKISASSGVGVQCNERAVKINLCKCEATTGMIVRRWRQQHANDEDGGHQLFRWRETFAAERRKSTWSGMGSFGRAETGEQKEQWEKISAAFPPPSTPEVPTHKTMLSRNLNRLGSRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS73</accession>
    <name>A0A084VS73_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01015829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS73"/>
    <dbReference type="STRING" id="74873.A0A084VS73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008252-RA">
        <property type="protein sequence ID" value="ASIC008252-PA"/>
        <property type="gene ID" value="ASIC008252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008252"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018405"/>
    <dbReference type="OMA" id="MSECEVM"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9985" checksum="97151A3402B4E02E" modified="2014-10-29" version="1">MSNISEFYRDKVVFVTGGTGFIGKIVVEKLLRSCGVKEVILMVREKKNTQPEQRIKTLCSSPVSRKPCPKIIVLQIGLYNPPPWFVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSJ0</accession>
    <name>A0A084VSJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010932-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008469</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016041">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525054">
        <property type="protein sequence ID" value="KFB40934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSJ0"/>
    <dbReference type="STRING" id="74873.A0A084VSJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008469-RA">
        <property type="protein sequence ID" value="ASIC008469-PA"/>
        <property type="gene ID" value="ASIC008469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008469"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020980"/>
    <dbReference type="OMA" id="PWHVGLQ"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="365"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="494"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="590" mass="67949" checksum="5930057326ED0207" modified="2014-10-29" version="1">MGSSSSESEEERKHKKHKKKEKKSKKSKKEKKSKKDKKHKHRKRDRSSSVSSGSEADEWLEAAPVDINAKPEMRQSPAKLERDDWMNSMLIPTYSKEPKKEEKKTATNDPYDPKTSVRELNPHWKNGGSGLPSFRKPVMDDDDNAAREAYGSRQAITNRSQSRSANSGGWKKSAKDESHTRRDEKSDLEKTLSIVDQSKPAGNEAKTDQLLTDEQLNELGAKIVKAELLGNTVQATALKEKLETAKALRNEMQSKTKSEQGQEVAPKRRLSTEESVTYTVSKSYDGSQRNHGKKQKQYQQNLPLGPALQDKFRSERHENDSMDAQFFKVSAKMGEGKRLENIFDHERASSAVGEASATEERTVREMNRMSKAQTDCERCINSGRFSQDQLITMGKNVYLSIPTWRALQPKHCFIVPVGHYPSLTQVDEDVHQEIVDVCKALVQMFRKHQMEVVFFETVRYLNRNPHMYIQCVPAKDYEMAPFYFKKAILESETEWAMNKKLHNVDGFNVKRTVPKNLPYFWVNFNMENGFAHVIEDQESFPVTFATETIAGILGLDTRDWRKPRKEMNPAQKVDEFKNWWREFETVLRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTM2</accession>
    <name>A0A084VTM2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00008912</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01016361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VTM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008912-RA">
        <property type="protein sequence ID" value="ASIC008912-PA"/>
        <property type="gene ID" value="ASIC008912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008912"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001703"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016819"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019448"/>
    <dbReference type="OMA" id="FVAQCMN"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783780" evidence="2">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="312" mass="35956" checksum="4F3D48709C79F08E" modified="2014-10-29" version="1">MGILKGSIVISLCCILIWSAEPASAKSDSVKKMLHQIKDSIRENDGKIVKCQLQIETVHADLKKLQDDSEWLKKTIQETLFWQKYLKEIMLELHEARKRGPFGSCGAEPSKVSGKYLIQLERSADEFEVYCEQSKFGGGWTVIQQRHNGRVNFFRNWFEYRRGFGSAGDEFWLGLDNLHKLTAHRPHELLVEVKDFQGNYRYARYTSFQIGSESEQFSLKLLGTYDGDAGDALRYNVGQNFSTPDRDNDPWKGVNCAADRHGAWWYKDCGPSNLNGRYQNTDDDLEAMYWSASHSDWSGMAYTRMMIRGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUJ8</accession>
    <name>A0A084VUJ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Selenium-binding protein 1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009266</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525126">
        <property type="protein sequence ID" value="KFB41642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUJ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009266-RA">
        <property type="protein sequence ID" value="ASIC009266-PA"/>
        <property type="gene ID" value="ASIC009266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009266"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="10993" checksum="8FD677D3EFB46172" modified="2014-10-29" version="1">MLIKADPMPPKHTIGHLMDTVAHSTECCIFLADPVSPHRCQVAMELMLMMIGAQIGPLRLHSKASVCAKCGGLRISGPKEFSTLVQPMPAAACLSNGVRQPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV11</accession>
    <name>A0A084VV11_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Signal transduction histidine kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009511</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009511-RA">
        <property type="protein sequence ID" value="ASIC009511-PA"/>
        <property type="gene ID" value="ASIC009511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009511"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009511-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9606" checksum="E3152C8D66FADDDA" modified="2014-10-29" version="1">MVTLAADTNHNANGHSENPKRIGVREADGKRSTFHTLGSALKTQTEADDDDDDDGDGDVQENKTYFLILDTPNESSLRFIASGRNVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVE2</accession>
    <name>A0A084VVE2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009499</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cecropin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVE2"/>
    <dbReference type="STRING" id="74873.A0A084VVE2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009499-RA">
        <property type="protein sequence ID" value="ASIC009499-PA"/>
        <property type="gene ID" value="ASIC009499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009499"/>
    <dbReference type="OMA" id="APRWKFG"/>
    <dbReference type="OrthoDB" id="7410372at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000875">
        <property type="entry name" value="CecC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020400">
        <property type="entry name" value="CecC/Srx/CECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329:SF1">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00272">
        <property type="entry name" value="Cecropin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 9" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7 9" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10559" checksum="5BA7CE92C9461D69" modified="2014-10-29" version="1">MAHQFGPWVLQNCTFVRSFVHRRSTQSKMNFRRLFVVLMVLVALLMVGVPPVDGAPRRWRLGKRLERLGQNLFRAAQKALPVIAGYKALGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVG5</accession>
    <name>A0A084VVG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">IucA/IucC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009527</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009527-RA">
        <property type="protein sequence ID" value="ASIC009527-PA"/>
        <property type="gene ID" value="ASIC009527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009527"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11516" checksum="3AE8178E4BCEAFE3" modified="2014-10-29" version="1">MLGVKNLSPNGPLIASRHREVRAVRKTPADYNWKPPRPGKASHRTHARGRPSPAREGDGFSEPNSNLQQPSPRQSDPPANHHRVAITRPVQMYAACRGPIRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVI2</accession>
    <name>A0A084VVI2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00009547</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="ATLV01017185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VVI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009547-RA">
        <property type="protein sequence ID" value="ASIC009547-PA"/>
        <property type="gene ID" value="ASIC009547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009547"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020699"/>
    <dbReference type="OMA" id="QMYGNDK"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000044">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000104">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000034">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1192"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1222"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1042"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="903"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="989"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="995"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1019"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1020"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1020"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009547-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1321" mass="149700" checksum="1E725A92874497FF" modified="2014-10-29" version="1">MFFTPPEFLFLDYPQHPTKSPKLNKCNIVCYVRNPFQGNRVSQEADSLSVKVGRDSQEKKEKNSNESNRIKSTKYTLLTFLPMNLFEQFRRVANMYFLIMTVISIVIDSPVSPLTSLVPLVFVIAVTAAKQGYENFLRYRADNMVNFSPVTVIRSGVAEDIRCQDIKRGDIVMMTRDCDIPCDVVLLQSSDENDRCYVTTANLDGETNLKTMSVPKGVPRLPMERLHTIGRIEYELPHTNLYSFKGRIELADCHLAAGEHSLLPLMTENLLLRGSRIKNTEWAIGCAVYTGQQTKLALNSKMTTSKMSSSERFINMYLVFFLVLLVAIVTVSYFLKRYNDRYRQEHNAYLGEILANYRVSQFLQDYFSFLILFNYLIPISLYVTIEMAKFLGGFYLEWDLEMYDEETDQQCIVNTSDINEELGQVSLLFSDKTGTLTKNIMIFQQCSINGRKYEQKGRRLQESGRRYALKINELSKHVYNFFQALAVCHTVQVAGDYTTEADELKLPATPLQPNTDDRLPLETMSISEEETVPPPQDTSSNPTEEFTMPDERDRIPTTLVRRHPVSLFEGKNRIVPVENIDPLASDTEVRRPLRPISLVEPGSVETSFILEHSGNGGGSNGNLGIPSQLELKRTISAYEEKPTPPSGQDLKKIGHRRTQSHIPPGMESYAAPAYNQDSVIQRQESQVKRQEIDNFIQKMDYQASSPDEKALVEACARMGLVYVGEDGDRMNIKLRASCVKADVRSRIGEIPEEELVQYERLAVLEFSSDRKRMSIIVRDSSGQIWLYTKGAESHVLPLCATSPLIETTQQHINEFAKLGLRTLAVARRRLTAEEFHAFNDELIEASSSLTDRTAKIEECQRKIETQLELLGATAVEDALQDNVRDTLQSLGKAGIKIWVLTGDKVETALNIALSCGHIPDGAERYFITDCSTVDQVQQHLDTLSLEMFRQRGATFALLIDGGSLTIALESLKEQFRDVSIRCHAVLCCRLSPLQKCEVVQLMKTVESAPVTAAIGDGANDVSMIQEAHVGLGIVGREGRQAARCADYAFAKFCMLKRLLLVHGHFFSTRLAVLVLYFFYKNLVFMGVQLYFQIHSMFSNQSVYDSVFLTLYNVVYTAVPVLVLALTEKPYQEQTLMKNPQLYQTVAGNKQYAWKYFIGWMILGIYHFSVIYFFAYAVWTINPAVYSYWPSTASFSCYGTILIHNVVVLVNLKLLLAAIYKSYIFIATVLLSIFAFMGSTFVYNLLHTNYDGSMLQVYNNLLSSMTFWLLSFVILIAGFLPDMTMLAIRAIGVKLGHIFPGGAKYRRALFQWRDDRLQSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVJ9</accession>
    <name>A0A084VVJ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009569</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVJ9"/>
    <dbReference type="STRING" id="74873.A0A084VVJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009569-RA">
        <property type="protein sequence ID" value="ASIC009569-PA"/>
        <property type="gene ID" value="ASIC009569"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009569"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008489"/>
    <dbReference type="OrthoDB" id="6281275at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="144"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009569-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="836" mass="90004" checksum="348532662DDD1C73" modified="2014-10-29" version="1">MAEKVPAGIAPSGGAFVVVNSPDAHPRSNDIIMHNIAIQPLPVAVEPTPSISHPHSSGGGSSSNNAYVRPSGAQQACVSKPANKIVAPGVLAGPRNVVLHRHNGDFGFTLRHFIVYPPDSVTDPAVNPLAAVGVLNFAQPMDTVFVKKVHPNSAAHRAGLQEGDRLLAVNGLTVAAIPYSQVVATIQQTPKTLTLQVVPKNYDILQTFFSETAYNPETNQRPQPQAVAVPKVAVQQETPPQPYHPPHLLAMASAQKKQESLYSTLQEIVVENVVEAGAGMSSSKKTAIYDEVPKIVANRLNKPSATQQQQSPPQQAMLKAGGSKGLAMEQLLSKQQQYSHMQQQQQQQQQHLKHQYLEKITVHEKDCKPYGNGSSPMVLPGEDEYATPCGQSDSIRMSRLRKSLEQKEEFLRRPLVAAFDRGVMQQGAMAGVPTNDGQDIAQHREFYGRPNRFNKLVWPPTTTHLSLEHPQEQPISAPSGNADPTGGKAVTESTIVPLSTGASFQTATTSTRTHVSQLSSIREQFFIGSPAETMVQTPPKSAPPSLTVAAVSPAPPRPPPMAGTFSVASLPLPSHAAMHGVSEKTKLFESGRALSPEGFDRMNLYKSELSRINTKQVVPNVAVRRKEFELKAESTSRRMSTEDKQRSVSSDSESQRTPVRMRSLSDEPNATQKAFGRASFPPMNPFNEDNTKPLDEQCQDSAAATASHGSSPQSGDQTNRTGNEPSTAGVVMRPKQQHSVMGGKDDRKVRRISYLRATARENLFHLIESDAALGSSEPSDETGTTGESTMSEASGAPASSSPSQQQQEASAIDGDGLLTAGKVKSSAFVQSVQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVM6</accession>
    <name>A0A084VVM6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">lysoplasmalogenase</fullName>
            <ecNumber evidence="6">3.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00009599</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:22544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:16905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
            <dbReference type="ChEBI" id="CHEBI:143890"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.2" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01017198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVM6"/>
    <dbReference type="STRING" id="74873.A0A084VVM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009599-RA">
        <property type="protein sequence ID" value="ASIC009599-PA"/>
        <property type="gene ID" value="ASIC009599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009599"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008168"/>
    <dbReference type="OMA" id="VEKRCHT"/>
    <dbReference type="OrthoDB" id="2133758at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047408">
        <property type="term" value="F:alkenylglycerophosphocholine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19758" checksum="6EDAEEA6581DB18C" modified="2014-10-29" version="1">MRILGGLLFSSLGDLLLNYELFEAGMGAFGVAQVFYILAFGMKPLKIWIGVLLYACGFLATSLFYGNLNSVIKICLPFYAILLLTMCWRSLARVEGTRNYLRMMCGICSVLFVISDGIIAFDKFYVPISAAQTYIMVTYYVAQVGIALSINDFQTDGSPIKSQRSIDSRTKVQKTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVP1</accession>
    <name>A0A084VVP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000870-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009616</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VVP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009616-RA">
        <property type="protein sequence ID" value="ASIC009616-PA"/>
        <property type="gene ID" value="ASIC009616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009616"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002416"/>
    <dbReference type="OMA" id="EFRYMIT"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22207">
        <property type="entry name" value="pseudoGTPaseD_p190RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057284">
        <property type="entry name" value="FF_RHG35_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039007">
        <property type="entry name" value="pG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032835">
        <property type="entry name" value="RhoGAP-FF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045786">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039006">
        <property type="entry name" value="RhoGAP_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23083">
        <property type="entry name" value="FF_RHG35_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16512">
        <property type="entry name" value="RhoGAP-FF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19518">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51852">
        <property type="entry name" value="PG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51853">
        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="430"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PG1 pseudoGTPase" evidence="6">
        <location>
            <begin position="592"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="7">
        <location>
            <begin position="768"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1519"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1421"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1386"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1478"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1732" mass="195505" checksum="E2CF3E661324E608" modified="2014-10-29" version="1">MKQINVSVVGLSGVEKDKGQLGVGKSCLCNRFVRPKTDDYAIDHISVLSQSDFSGRVVNNDHFLYWGEVRKTSEEGVDYNFSVIEQTEFVDDATFQPFKVGKMEPYIKRCAAIRMSSQEKLKYICKNQLGIEHEYEEVVLPEGRFLVDGFVCVFDVSVVPNRTVEKQVEFVTQIINNVLKNKKPVVLVTTKNDDASELYVREAEKICSRKEYKGQILLIETSAHESINIDLAFIVLAQMIDKAKQRSKIPSYGEAAKQRTDLLTTSTEFVTRLIRTQITDHRLIWTTSSKKLASHREWNDFLELFGKEAGQRIFRRHIKKLREDYQSKKLQSYMDSFACVLQEILPDINSINIELDSFNDWASIRGYFRNHIDYEQYFFDAVERGGSWAELSDMSDMEDENRIPFDILDTPEAETVFKNHMNALQQEQKRLEWKKQFKKLLEETGYVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDNHQRELVESAKHNFQELLMEHADRFYHFKNIEPSGTITQNDIKEITDVLQEDLRYKLLDRLDQDRKVMLFQHLGFVHCPIREHCPAFPNCMDALIERILIANQNLPNPRFAQKDGQLQLNLIVIGLDYIANDFIDKIHQNCNDNGEYIFDGQVYGLNIETINRDNDSFSFELQSKGLICCYSNRATFQYVYEVLDRLLVDNLDFKDSVNNLHIVFMSDEKNGQSTLHQLQADGQSLAEKLHCVFIDENEFYVSQQQAKFVDTTLNSVIESIPFEDLKYGLALHDLPDLRLIMCIFCGDPFSVETLLSAMMLEQSCVSAGERNIIFEMFLGDSKRRVELILSSYHGANAFRDDLIHGFILLYSSKRKASLSTLSAFSLNIPNLPMQIVAVSEQGGANAFFASELSQLLITEGNAIADKLRAHFATASDDDGQFRFASFAPFLKEVWDKKPEIEHAFNMEEPLTIDSGEGTMEHSMHHHHQQQVPQPPPRYESYLINGSSTTYRGGSGGGGPLHPHHAQQQQQQMHPHQHQQKMSQQLFDNRSINSLDDLDSLKQQAQQHQHQQQLHHHQQHQQQQQQQQQYSNMYYYEDSSDFDKGGSNQGFQIYPPPTTPPEPAPPDHLLTPSSILRQLKANTVSQSQSSLEEINCWLDDGFLIQKQDNKQSEDLWKNVNAHHAFTTGRRPNQSSFAKKIRPKGPSQTLKQPGKLNLKSFAIVNEAIARMNIGGGGGGGPGGDGGAATGNNHPGMGIPMTEKEKKKAKKLLQQQQQLEHAPLAAPEDDSEEYEDEAGYEQINDAFSDAVNNVASQLFTTFSSGGGGGSAGQGGSGPGGHEMGTNKNKLRQRREKEQIFNIQEYSDSESDSSSLERKRSNDGYSKINRKAQPHKRHRKKRTAIPVQPPKIPLGPFGSSAGGPGGGAGVELLGGGSGGGSALSSALGMPMMYQKLKNEPGSGGMEKPERPAEQDESSVDVSSPRDNNSPIFGVLPKGGEREKLITKQKNWFGKEIDPSSKSSKESKEARSSSKSGGKNSKNSAAAGAQAQQAALASLKQSDKVPLVPLFVEKCVKFIEQEGLDSEGIYRVPGNRTHVDLLNQKFAEDTDVDIEKLDIPVNAVATALKDFFVKRLKGLFSAEMMSELEEIAGSRPLQSITSLNMEVKADRSCRLIALRALLNKLPPNNFAILSYIFQHFVRVSENSKLNSMDSKNLAICWWPTLLPIEFTDMMRFETMRPYLEDIVQTMIDQYPFLFRGEEAFVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWA3</accession>
    <name>A0A084VWA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009963</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWA3"/>
    <dbReference type="STRING" id="74873.A0A084VWA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009963-RA">
        <property type="protein sequence ID" value="ASIC009963-PA"/>
        <property type="gene ID" value="ASIC009963"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS012766"/>
    <dbReference type="OMA" id="TVIYLYS"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="HERPUD1/2"/>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
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        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
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        </location>
    </feature>
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            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
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            <begin position="319"/>
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        </location>
    </feature>
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            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
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        </location>
    </feature>
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            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB42247.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009963-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="620" mass="63866" checksum="15583A255382F80F" modified="2014-10-29" version="1">MDVTLIVKASNQQCEDLTIKCEPSWTIRRLKGHLTEVYPGKPSSDEQKLIYSGQLLSDSVVLKDVLRQYDGQQAHTVHLVFTPKNSYYGNGGSSSSASKTNRNTNGGSKMASTNPSSTSGASSSSAASSSSSPGSSNNNDTTSNGAVSGGSREHEETSAVDGVVGSDGLRQRTGLQTRPGLRTLPGPPPFMEQTVALQNLMQQTYMQYLNQYINMINEQGGINALYSATGVPPTAGTATAVNPLTGSPVFPSVPFVPVQQSAGTAGSYPNFAYYPCMTPPSSHVGGLPTASSIPTPIVPAATGSSGSAQPGTTTPGFLPSPAIPSTSTSASQPTPTSLLSSGGVTTPSASSDAGASSSTAAQAAGTDTTPAVAPAQAAAAPQDDAVANAAQGRARRFPNIVVEEQENNDWLDVFFSMCRVGILMTVIYLYSSPMRCLTVLFIGVMLYLKKHLDRVYQAIDRRFTRLPAAQEGNAAQPAAAQPNNNVPDQQGSPARNGGGDTGNDQPGSTGGATSEAAARTDGTVAEGETPGTPSTSQSAAPVPRPRTGPASGTAEPNTAAANNNTETEPLLERPATQSDSSSAEQPAAEGQRMTFNDMTSFLGTLVITFFTSIIPDTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX12</accession>
    <name>A0A084VX12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013055-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX12"/>
    <dbReference type="STRING" id="74873.A0A084VX12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010213-RA">
        <property type="protein sequence ID" value="ASIC010213-PA"/>
        <property type="gene ID" value="ASIC010213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010213"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015487"/>
    <dbReference type="OrthoDB" id="7791521at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF22">
        <property type="entry name" value="AGAP013055-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
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            <begin position="119"/>
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        </location>
    </feature>
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        </location>
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            <begin position="465"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB42506.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="493" mass="53549" checksum="FA057F82B2656378" modified="2014-10-29" version="1">MLRAAHARERSSFFPSVLQRPESDHAGVSLCIATGNRIITTAATTYTTFTNTTTTNNNNIIAALSVAYTFAAKCCITFCRAIDNSCDRPPEEGSACVCEASKRKKRQEEVCAKNRKKENRSNEEEEVRRKGSKVGPTAHDGFLCCFVVPPSPPPHSIPWCQPPERTPEEEEKEVRAVVCRRAPVLCPRLCLCVSPYTWCVSAHRDCVDRSVFPRSSLTTSLSSPCRSAAYATDKTTTGTDTTAATSSTNSSHQCNKECSAAGAERRKTMEIHVKQCKQRNRRRERAQRMIAERDKDAAADATGNRDPDDSADEDSGPLSREKPHRPPVRRKRKEKEPSPVLEEDIIDGFAILAFKTYEDIEFAIKIANKRNEKRLSSIVELTTVMVQEEKPPKIIDTTPSKLAGADKVALVDGLSVASLNNNSSSNNNNSINSDGQSQAAGVNSNHHPLHHPPHHSLHHPALQTGGNGNSGGGGGGGAGTEVPVATTLVSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY39</accession>
    <name>A0A084VY39_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010638</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018274">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010638-RA">
        <property type="protein sequence ID" value="ASIC010638-PA"/>
        <property type="gene ID" value="ASIC010638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010638"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9608" checksum="B64B7F20676B2533" modified="2014-10-29" version="1">MHWPTRTKLLGWTLAGAPDARDDYDGRQANFHTPSSQPKLPASSKLLHSKGILQQSYPLEGRSFARHGDGFRMHAAPTTARRPGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY47</accession>
    <name>A0A084VY47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">DNA topoisomerase 2-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010650</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525227">
        <property type="protein sequence ID" value="KFB42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010650-RA">
        <property type="protein sequence ID" value="ASIC010650-PA"/>
        <property type="gene ID" value="ASIC010650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010650"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8065" checksum="473D66FA2E4DA77E" modified="2014-10-29" version="1">MTRSDFPPWNQARIHASVVHRQASADAGQEDCFHNTITYPQRVREEASNYRANGGGLEDIASETRTGCGSTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYG3</accession>
    <name>A0A084VYG3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008842-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010678</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYG3"/>
    <dbReference type="STRING" id="74873.A0A084VYG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010678-RA">
        <property type="protein sequence ID" value="ASIC010678-PA"/>
        <property type="gene ID" value="ASIC010678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010678"/>
    <dbReference type="OMA" id="MIMIYLS"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9003" checksum="259BD6A30590DD48" modified="2014-10-29" version="1">MHPSRVKQIVGVSDITENRNIWRMLIAEFLGTFLLVSIGIGSTTGWTDYSPTLTQIAFTFGLVVATLAQVGNVVAGSSSFVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYX0</accession>
    <name>A0A084VYX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010937</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525236">
        <property type="protein sequence ID" value="KFB43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010937-RA">
        <property type="protein sequence ID" value="ASIC010937-PA"/>
        <property type="gene ID" value="ASIC010937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010937"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10573" checksum="3D961E20978555DC" modified="2014-10-29" version="1">MPPCPCSAVQLVQPARLEDFTVIFMSVIVCRDFNYLIRPGKLPIESLDGSISGEPHHPTLTEVKRPVEVPVRRLKIILPTAGRQLRSPAAIEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZV8</accession>
    <name>A0A084VZV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011313</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525258">
        <property type="protein sequence ID" value="KFB43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZV8"/>
    <dbReference type="STRING" id="74873.A0A084VZV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011313-RA">
        <property type="protein sequence ID" value="ASIC011313-PA"/>
        <property type="gene ID" value="ASIC011313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011313"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006383"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011313-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12416" checksum="312F9CB293ECB467" modified="2014-10-29" version="1">MFAEIDESVITPAKILSDILEIEVSSDLAHSQIVCVNCNMMCLEYQQLIQRAETIRIEMTMAYNQTVMKLAGLTEKDLKENEEAAGSSEEHVESALHNFNKELVSIRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W056</accession>
    <name>A0A084W056_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">tRNA pseudouridine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011538</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W056"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011538-RA">
        <property type="protein sequence ID" value="ASIC011538-PA"/>
        <property type="gene ID" value="ASIC011538"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011538"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011538-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7406" checksum="EE248EC76153E7F1" modified="2014-10-29" version="1">MEAPGHPCRSLIRGLRRLSVNFTVDTIDMKGRVGQVFYVQMYKCAPQDKSHSDYGQQRQTMMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0D7</accession>
    <name>A0A084W0D7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011409</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0D7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011409-RA">
        <property type="protein sequence ID" value="ASIC011409-PA"/>
        <property type="gene ID" value="ASIC011409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011409"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10663" checksum="842404B55AB0D958" modified="2014-10-29" version="1">MSDGVRDAGIGSAGNRLPVVRTTRQRGSIKADQISGQTTNDALQWNGEKNGGEYIGIGSIRNGKMSMYGGPKKKPADRTLVVIGEKLQKHIDPELGGDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0H9</accession>
    <name>A0A084W0H9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP012985-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00011456</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0H9"/>
    <dbReference type="STRING" id="74873.A0A084W0H9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011456-RA">
        <property type="protein sequence ID" value="ASIC011456-PA"/>
        <property type="gene ID" value="ASIC011456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011456"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020216"/>
    <dbReference type="OMA" id="KVPCLHC"/>
    <dbReference type="OrthoDB" id="7777957at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="65"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB43723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="41720" checksum="AC2BF38322FBD37F" modified="2014-10-29" version="1">MAAFVEPHFDAWTQSGGNMTVVDKVPPEMLHMVHPHWNQFPPMNPLWHSILGFAIFMLGMISMIGNGCVMYIFTNTKSLRTPSNLLVVNLAFSDFFMMFCMGPPMVINCWHETWVFGPFACELYAMLGSLFGCASIWTMTMIAFDRYNVIVKGLSGKPMTNNGALLRIFGVWAFALFWTLAPLFGWNRYVPEGNMTACGTDYLTQTWLSRSYIIIYAVFVYWLPLLTIIYSYTFILKAVSAHEKNMREQAKKMNVASLRTQEAQNTSTEMKLAKVALVTISLWFMAWTPYLVINFTGIFKAAPISPLATIWGSLFAKANAVYNPIVYGISHPKYRAALYQKFPSLSCQDTTPADDGQSVVSGATQATDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1B7</accession>
    <name>A0A084W1B7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004715-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019258">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1B7"/>
    <dbReference type="SMR" id="A0A084W1B7"/>
    <dbReference type="STRING" id="74873.A0A084W1B7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011841-RA">
        <property type="protein sequence ID" value="ASIC011841-PA"/>
        <property type="gene ID" value="ASIC011841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011841"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021741"/>
    <dbReference type="OMA" id="TKFPDRE"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000003">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000004">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="440"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="498"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="808"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011841-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="930" mass="104904" checksum="13FC93542D5FC8A0" modified="2014-10-29" version="1">MHRNIIIKSTHLNYPRFLHRFRHVCGSNIVEAEANLSLLNDQQKSTVRCCYSTIAGPERWDDGLPSDFSNTPPKDARVVICGGGIMGAAVAYQLAQRGWGQHTVLIERGRIGEGNPWHYSGLLGELKQSHSQVLLAQTSLELIRDLDAKGLPTGWKQTGSLNLARTRDRMTMFRRMKSQSVAWNVQCEIVSPEKCKELCPLIEISDIVGGLWIPNDGVGNPNAFCHSLVQESLEKGVTVSENCSVVKVIQKDGRVKAVETSKGTVECVYFVNCAGFWARQVGQMSEPYVKVPLHAAEHYYLHTKPIPGISAQFPVVRDLDGHIYFRENDGCLLAGGFETKAKPAFEDGEIPVSTSERKLIPDWDHFHPLLEELLLRCPQLKDVPLDRLSNCPEAFSPDCKWILGEAPEIQNYLVAAGMKTVGMSAAGGVGRAIADIITQGYSTVDLHELDISRFLGLHNNRKFLRDRVREVPGMHYDLSYPFHEFRTGRNLRMSPIFPALKEAGAVFSQVMGYERPAWFDKKHSQDEKGSPKFRIATTHGFGKPHWFEHVQSEYENCRERIGMSDYSTFTKIDLWSKGGEVVDLLQYLCSNDVDQPVGSIIHTGMHNRHGGYENDCSLARLSENHYMMIAPTVQQARCKAWIERHLPPGGRVSVSDVTSMYTAICIMGPFTRIMLSELTDTDLSPKSFPFFTCKELDVGLANGIRALNLTHTGELGYVLYIPNEFALHVYTKIMEAGQKYGIRHCGYYAMRTLRVEKFFAFWGQDLDTFTTPLECGRMWRVKFDKAVDFIGKEALLQQREKGVERMYIQLLINDHDPDVDLWSWGGEPIYRNGVYSGQTTTTAYGFTFKKQICLGFVKNLHPSGRALPVTNEYVLSGDYEVEIAGIRYPAKANLHSPNLPTKYPDQEREAYKATRDKTDESNLLAFRTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2P7</accession>
    <name>A0A084W2P7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012394</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019666">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525277">
        <property type="protein sequence ID" value="KFB44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2P7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012394-RA">
        <property type="protein sequence ID" value="ASIC012394-PA"/>
        <property type="gene ID" value="ASIC012394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012394"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="14128" checksum="E196F51B446DF55B" modified="2014-10-29" version="1">MPPISVRIPMHPISRVSGRFTLECTLSADQWPRGRTNLQQSASASTRSNVKVKPRRTPKSGSIPPLESGRNRKDILLQRERRRQPEPTRADRIKSRPEDDDCDGLTRRWPTGQHQRHGADRAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2T8</accession>
    <name>A0A084W2T8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein CLEC16A isoform X6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012412</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019695">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525277">
        <property type="protein sequence ID" value="KFB44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2T8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012412-RA">
        <property type="protein sequence ID" value="ASIC012412-PA"/>
        <property type="gene ID" value="ASIC012412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012412"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012412-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6804" checksum="0157498FB29A9F9F" modified="2014-10-29" version="1">MLRHPGFDPCTMPTSGEKVNINTWRRMEELLHTGGPPTVTNTGTCSAPPGEECCSCAEPISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W349</accession>
    <name>A0A084W349_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002778-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00012530</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W349"/>
    <dbReference type="STRING" id="74873.A0A084W349"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012530-RA">
        <property type="protein sequence ID" value="ASIC012530-PA"/>
        <property type="gene ID" value="ASIC012530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012530"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007313"/>
    <dbReference type="OMA" id="RMAAYGC"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="139"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012530-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="561" mass="63377" checksum="436BA39DE3C5B6AB" modified="2014-10-29" version="1">MGREILTFQLGNYANYVGTHWWNIQESSFNYDPNAEPSEIDHSILYREGQTSQRQVTFTPRLLMVDLAGTLGHVPRTGDLYADPLDPAQISDDPSELTDVEWDAQKLEIIKQEAPAKRHPYQTDLASGSTEGEKDYDFANTVENWIDFSYTRYHPRSINVIERYTHSKDENQFDTITNGMELWKDMDFQDELTDRTRQYVEESDACQGFQMLFDCTDGFSGLGLKLLEHLQDEYGKPSLLFPVFSPKPPMFKSADEAMSDSIRVINTALAFAQLPEYASLFVPLSTMQRCWRNIDGPRTLPNIAYDAANLYQTSGILASFLETATIRYRLKEPASGGFLSGLCCDLNAYGRKMAAAGMAMPFPLGSTQDLIDCLDQLEDKSLSVQLSPNVNVGKRAIVQSVCVRGLPLNRLKRPPTAKSAQRQQIMPAYRCTSVSEMLQFFYSCSLEVSMSHVTSIKAPMSIRQPFPVEVFDKRVGFDGFLTDCPLAQATMAYVQQCPTLATIQSSSDLGDGLEALHREVSRIRLAKIPRFTECGLEEVDYKETVERLLDLKENYDENYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3C7</accession>
    <name>A0A084W3C7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003280-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525285">
        <property type="protein sequence ID" value="KFB44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3C7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012632-RA">
        <property type="protein sequence ID" value="ASIC012632-PA"/>
        <property type="gene ID" value="ASIC012632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015169"/>
    <dbReference type="OMA" id="LYRQEMM"/>
    <dbReference type="OrthoDB" id="7985911at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="810" mass="90447" checksum="DD51421DE005A3D8" modified="2014-10-29" version="1">MEDNIISMFMDVKLDIRERKLEFSHMKSWSRYFVRVEAVKCFPCYMRISFFTSPTDLTTDLIVRINIPGLTVQMATSRTKQHSYGLFWKNNRKRCCAYFALETQLLCERHLRWMKKSIRNLELYRQEMMQLRRASRTPLYEIRQEMQPIDPVHGPVGSPANVVWDDMGIYQNLDNTQNIMGLQDILGPLPNVPPAMERADGNGSVNCSRRVSGMSGIYEEIRDHPRLSRVSIASGIYEEMKLVVDGKDTPTANPPQADENASDSPPPPLPPRPRSNTNEDFDLQRSFTTPEVDLMKKKRHWLRLDTMFGRRRTTSTESQGSGTSKKRCSSSKNSKKLRSSEERMAAEKDASEVVIHRGKVSRLRLAENKRNSFSSPDLSRLKIDDTQQHEPGVERMCDESFENLSEGDGSCTSEFYAPNHDIDFIEEDFASSEFINMSTTSSLGAGVNSGKFERRQEEEELDPLRDFRRLNISERIFEGFNRSMNCSTVNLVGAGCNASTIEETTEPDPSPARVPPAPLSDADMVGYLEMGPAGTGFNRQKLDEVIYRNQPVGASCGAAVDLGPKVIEESIYMSMDGTGKLPEPIRSSSTSSSSSSSSGVSSASDHSTLTEGSTKHRNSVDDKIPSYYPNEDFVRTPPSRRSPPDGKRSPGQARDKIVTPIATTLPRTIKSVQRAPADSTTAIQDRIHATFRTPKATSNRRPNPRNLLQLPEPTATESVAPESSGSLEPSPKLYQKYATLARITSPSKYSPRAKPEDGSSAEFGPVPAITTTPVTSSRRFGSLPRFGKIDLSPLRMKINSVLQRHNSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3D4</accession>
    <name>A0A084W3D4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP003271-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00012623</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019919">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019920">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525285">
        <property type="protein sequence ID" value="KFB44728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3D4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012623-RA">
        <property type="protein sequence ID" value="ASIC012623-PA"/>
        <property type="gene ID" value="ASIC012623"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012623"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021651"/>
    <dbReference type="OMA" id="WWKKASW"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
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    </dbReference>
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        <property type="entry name" value="AAA_8"/>
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    </dbReference>
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        <property type="entry name" value="DYH2-5-8_CC"/>
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        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1990"/>
            <end position="2134"/>
        </location>
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    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2269"/>
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        </location>
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        <location>
            <begin position="2623"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="82"/>
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        </location>
    </feature>
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        <location>
            <begin position="918"/>
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        </location>
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        <location>
            <begin position="3249"/>
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    </feature>
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        <location>
            <begin position="3469"/>
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        <location>
            <begin position="90"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB44728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012623-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="4664" mass="536857" checksum="1284AD6577524999" modified="2014-10-29" version="1">[encoded data, 4664 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3N5</accession>
    <name>A0A084W3N5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020065">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9273" checksum="BA38152A00815E08" modified="2014-10-29" version="1">MANSDGKCATQREKKGKEKTIPPARLAVVMVMIGTFFTRKLPTGRLRLASVVAFRPGWKLSTAYGLLAFARPILAASWLVQPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5P3</accession>
    <name>A0A084W5P3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AGAP010295-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00013483</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5P3"/>
    <dbReference type="STRING" id="74873.A0A084W5P3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013483-RA">
        <property type="protein sequence ID" value="ASIC013483-PA"/>
        <property type="gene ID" value="ASIC013483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013483"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002275"/>
    <dbReference type="OMA" id="THVARIW"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000064">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="17">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB45537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="680" mass="78604" checksum="D6265C77DC7F68E4" modified="2014-10-29" version="1">MYFPSCFHSVCSLLYVSIDSHTENFGPIYNYRPLVATYYIIYIIVIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPNDDRIQYQVWWFVTSQLFEYTIFILIMMNTITLSMKFYRQPQPYTEWLDVLNLVFTAVFALEFVFKLAAFRFQNYFGDAWNVFDFIIVLGSFIDIVYSEVTTSSGTKGASTIISINFFRLFRVMRLIKLLARGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGRIALDDETAIHRNNNFQTFPQAILVLFRSATGEAWQDIMLDCSAREEVRCDEESDEKNPTEGCGSNFAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLKIKTEGNIDDANIELRHIIKQIWKRTSNKLLDQVVPPPGIEDEVTVGKFYATYLIQDYFRRFKKRKTVDRNSEPSSHMTLLAGLRILHKRGPKIKRKISGTLHESASTNNPEPSHRRNHNLFGITWPTSAALKKRYFANESVVRSTRPENRPVRPPRTYATLNKGFRDVNKAILYGFRTMHDHNPLKGKDDGDTGNEGSLKPLCFGEIYSKQTSRVVNAKESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6R0</accession>
    <name>A0A084W6R0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Nonstructural polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013868</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6R0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013868-RA">
        <property type="protein sequence ID" value="ASIC013868-PA"/>
        <property type="gene ID" value="ASIC013868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013868"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12319" checksum="4863362B8CFA7D84" modified="2014-10-29" version="1">MLIGQTYDPPRPSSSVAVPAAPEGVVVNFLGVFRSIATTHDDGGNSDHGLGPEASDGGAKPSKHAIFVLSGVRNGTGIYLVRSGVYLWLDERWSFLHAEKSPPGEVYGTTNWFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7A3</accession>
    <name>A0A084W7A3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013054-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7A3"/>
    <dbReference type="STRING" id="74873.A0A084W7A3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014074-RA">
        <property type="protein sequence ID" value="ASIC014074-PA"/>
        <property type="gene ID" value="ASIC014074"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014074"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001024"/>
    <dbReference type="OMA" id="FMGHEVK"/>
    <dbReference type="OrthoDB" id="10057854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048998">
        <property type="entry name" value="STPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21107">
        <property type="entry name" value="STPRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STPR" evidence="2">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014074-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="39623" checksum="5BC38FD92CBC325B" modified="2014-10-29" version="1">MNAPYPPPNTCYTDIKQGILSYTLPLRTEITDIPGPPISLLPVAEKSPTSQSKKKRRAYVNESEEARARRLARNAERMRQKRATETEEEYRRRLAKNAESNRRKRQNETELERTIRHARSAARERLRRAMETPEQRAVRLAKLAERMRVSRANETPEQRAMRLAKNAAKAKERLLKESPEQWIERKRKKAEYARRKRSGGPLSSSAGSSSSNDAAVHSALTSPELSFSQVSSSHSYVPDLGHSTLSVAGTATPPDVKDIKLIASPKGQQDPQAQLPEQIYSTPQLSFMTTELKPPEYLHSVQHPVTTLQSDLSCPSNLYKFHILPYSIPPGAVSVPSSTSGLQHPGHTDYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8M4</accession>
    <name>A0A084W8M4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Histone H1, gonadal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014605</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
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                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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    <sequence length="149" mass="14917" checksum="C40D60EE4207973C" modified="2014-10-29" version="1">MYPNADGSDPYEKSHTGDGAADALRASVIRATTDSPMSPPHSLGGAAGGADSTMAAASGAATILLGTGSSAVPIGGLLGTRGAVSGKKMFNTGARSLLDVLATTERTNSQKRIDFSGRLCTPPGQIAKLYPHLGSKDADSGQGRSADVK</sequence>
</entry>
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    <accession>A0A084W9J3</accession>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
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                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="protein sequence ID" value="ASIC014922-PA"/>
        <property type="gene ID" value="ASIC014922"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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            <begin position="357"/>
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    </feature>
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        </source>
    </evidence>
    <sequence length="1598" mass="172239" checksum="276F8E47E32FE173" modified="2014-10-29" version="1">MQHRSRAHMFQIQVRALIKTLKCLQSDDKYQALLFLISAIKLYVKFLYNDCQERLYKPAILKELNNIENVIVVNLLKARGAGTASASASSVATARTSASSYGGGLASTTRLDLGSTSIRSTDLSLGGDGLLMMHPHRTQPHPPLMPWDLRGKLLRGNLFDGLPPTDSVRLGANISAAACNSLLKGGHRLASAARWLGNVRMTRALVRMIANHDFKLLFNMFEQSIFPTWKIYKNERIFVRKRPALTTVTVRTSLPAICYGSGSSHSPPATYIKKEEFDFDPPYSIADDHCFEEIKDEDDDDLLLMKEDDSIDISNEIFSEEESSTNNTSLMLSSDTNTLDTNDSSMVSHERNKEQSYQCLLCDKSYRKRKSLVIHFNLHPGYCPDCGKQRGVTSDEIVEHNRIYHKNRPHICEHCGETFTRNQQYQIHVQGHFISQKRVAEQNCKKIHKHCCKTCGIVFNNQKYLEKHIQKTNHQTEGVVCEICGAIFCNSVKLNHHVTRMHNNVFSQKASLERTMLLQQTSTSVVEKSYCCDHCGLAFLSQTTLRDHIKLAHTSLPEDVKSSQTATENKFECNICNKLFAAKRSLKRHKLCHSEERAFRCTVDNCKDAYKNQSHLARHMKTVHHIEPQKRLPKGKAAASAAAATAAAGGSSGGTSATLSTSTTGDPSRASSASADFIGHGIGDGVTMGGGSCDSLKVGGGGALKKSALGSSEKSLGDSSTNFSDNMSSFNYEFSDTTGGGSSTPALPSLGGREEGTPTLLSSAMLGAGSGSTMAPRSQAGAFNDPGISFATTSKQQQHNQLQQQHLSWQNLEFGSVPQHRSAATLAGGGGGGGGPPAQPMQDPLATQGSFMDAGHSQHHNLHHQAHHPLGPGAMGDPMGGAGGGGGGGVFMASNMMPGGARRFPLPETNLTCEHCDETNFVNAQQFQVHVQDHFVVKEGKEPAGKKLLRLICKTCNLVFATGPQLDRHIQKTNHHTESIACEICSAIFNSNLKVYQHMLKCHKNDIWFACEQCSKVFILKQDYDKHQLVHQTVTDRSIICEHCASSFLTQEALKEHIKIAHSMDKKYKCTICNKLFAARRSLKRHKLCHEEEAAFRCPVDGCTEAFRTAANLAKHKKMAHPAGLVAAPAPQVPGSIVAGVMVAHDSMGEPLHVATSKLPGTMVGGPLSATASGTMKVLEKVHQEPVVQNASIGQVMPGHHGTSPLMAMNASAAGMLKTEPRPSPSMGMVVPPSRTSSAGSSAGLGGSNTNSGSGANMPYNPYEASSAMHYNSVGLGVSPGSNIGPAGHGHHAALHHHHHHMQQQQQQQQQQHGGNQHHSSQQALPHHHSQSQFVGMTNPAGAAGLHYTSAHGGSRGGTAGTSSNLEQQQQPSTVGYRMAGDGSASVGPSGGNTGNIPYGYAQMANAYDWQNMAEMGNQTAGVEAGGIVGGANPGPTQVPSASASSMKGAGSKYYNAMHENNPGGAGGKRLSNNELYDRLQDMWNANMMKMEFQEEGTGGNGNSGAYNSLGNILTNLEMIGGSSNFESQAQQQQQQQQQGYDMIPASRTSADPHLGNGASNQATTLPTDVAKAQANNLPFVDSFTESIDYLQQSFQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDI1</accession>
    <name>A0A084WDI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016401</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023021">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016401-RA">
        <property type="protein sequence ID" value="ASIC016401-PA"/>
        <property type="gene ID" value="ASIC016401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016401"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016401-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11405" checksum="6C4C09EE7A92032E" modified="2014-10-29" version="1">MAHEEGGSNHQNDTIPHWFRCDLSAGSLLAVVGMCDIEKLQCTDIDEGRAWNLSAIGHRRPWDARIAYWISIQKEYRYNGRNYVFPPGANLRLTDVLSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDM2</accession>
    <name>A0A084WDM2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016297</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016297-RA">
        <property type="protein sequence ID" value="ASIC016297-PA"/>
        <property type="gene ID" value="ASIC016297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016297"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6357" checksum="22EF4F0436613F90" modified="2014-10-29" version="1">MLQRFLLYQMSRISFPGLGAAKTRGIRFQEGGSATFAMCYQMEWNTFDSNVLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDQ4</accession>
    <name>A0A084WDQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005028-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016555</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDQ4"/>
    <dbReference type="STRING" id="74873.A0A084WDQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016555-RA">
        <property type="protein sequence ID" value="ASIC016555-PA"/>
        <property type="gene ID" value="ASIC016555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016555"/>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="23780" checksum="48DBA80A64F170B4" modified="2014-10-29" version="1">MTHQSSPIHLFLSSRSLHVPPEATQSAWAAECSPPPTMIVSCVSIWVSLVFLSIPPLRQRWPVTTDFHYSELTITQASKEHSGNYTCVPSNSQPASVVVHIFKGDNPAAMYHEHRSSSTIPYRDRSTMAWFLAPLLLLLVRCWQLTALTTTANRSRPACDPIYWPPGDCSEPGNCKPHRSSAPLSASDRALRQSNGVPRAATNSSFRMVLAFHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEL3</accession>
    <name>A0A084WEL3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023222">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEL3"/>
    <dbReference type="STRING" id="74873.A0A084WEL3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016652-RA">
        <property type="protein sequence ID" value="ASIC016652-PA"/>
        <property type="gene ID" value="ASIC016652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016652"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013655"/>
    <dbReference type="OMA" id="IEYSHIN"/>
    <dbReference type="OrthoDB" id="7739973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="397" mass="45836" checksum="22E5E3EADA6342B3" modified="2014-10-29" version="1">MEDCVFSHAFIISREFEYQFGSGKAQPTEKKRIVFSSSTMKWIPNQLLDSFPNVEILYLENLQTEAIKSDVFRNGTRIKRLYLGNNNIETLDDDVFDDLHAMELISLDENRLVGLPPTLFQQARKLKTLTIAGNNLERIEDGTFHFTIELAFVNISHNKVNFFKFALIPSLLDIDVSFNKLKEVTVSQRLQYMNASYNHIGIVTGFSRKLRVLDLTSNNIHQTRWVQQFPELVELYLSHNQLREIESEPFLQLNHLQILLLHNNQLFAVDPSMNLPMLRVFDLSHNNLVNLDNMVHHLNKLESLSLDHNSLVTITPRVKNDQICISLAYNDWDCANLWTLSSALPQTAIKDRDGNCPAPYEDVRGICCRQNAATPYLERLLEINKESRKCEVDEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEX0</accession>
    <name>A0A084WEX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005361-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016771-RA">
        <property type="protein sequence ID" value="ASIC016771-PA"/>
        <property type="gene ID" value="ASIC016771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016771"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005788"/>
    <dbReference type="OMA" id="HASFACS"/>
    <dbReference type="OrthoDB" id="188749at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016771-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="420" mass="48659" checksum="DE72D403433DB3E5" modified="2014-10-29" version="1">MAEFAKERTFELFQKDFPRWLVNVHDPVELFRRQPSYLVSQVYCIVGALVCLAHALHRGGRWPFLWFASTFAGLLIEGAVYLSPFGETIWFSPTVIDLFGQRIPFFIIFVYPFFYYQAFWAVSKLQLKCRWSEHIAVGLLVVLFDLPFDMVSVKFLHWTLHNTEQMFAERVYSAPWTLLLFFFGSTFTFSYAFRHLRKLFEKRPAPATTNDPFAIRSTIPVELAASIGTAIVSVSLGSTLFLAVNYPLHTLLGISNKIVAVGVFLCVATIFWKFDRKSNRRLPFKQSLLDHLLTVFAVGHFWLYLVFAVFLNPQEASSIGRHQPIGDCRNQRTFLCLDSFRKDDFDFHCLPKPPKEGSYWYTICGTPFENRAEFVFVLMVITFVATLIQRTVHYDYDVRFKVYEFVKKSSATGTKAKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF15</accession>
    <name>A0A084WF15_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016823</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023274">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016823-RA">
        <property type="protein sequence ID" value="ASIC016823-PA"/>
        <property type="gene ID" value="ASIC016823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016823"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13639" checksum="05FE6434D23189E3" modified="2014-10-29" version="1">MTKLGLCSSTILSIRMKPASHFFHIRVKNQSLALRTVEENDGKHSLHSPWSSKSTTYPRTSRTSVSRNSSLATEKSVQSDREYGPSLTRAPESLTDTATPQRLSLSRSRHTSPRLEGKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFG3</accession>
    <name>A0A084WFG3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016958</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016958-RA">
        <property type="protein sequence ID" value="ASIC016958-PA"/>
        <property type="gene ID" value="ASIC016958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016958"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9090" checksum="F52ED65057239C6E" modified="2014-10-29" version="1">MVTEQIERPSAIRTTVQQYSCCNTDGLSKPSTRTSSIRAFCPIPRLCGTVCVSRDPSPEGGRENLSLFGVLGYSAFPACTMNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFI5</accession>
    <name>A0A084WFI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016983-RA">
        <property type="protein sequence ID" value="ASIC016983-PA"/>
        <property type="gene ID" value="ASIC016983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016983"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007582"/>
    <dbReference type="OrthoDB" id="10653971at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="28490" checksum="B0A24A3155F90098" modified="2014-10-29" version="1">MILITFVSIPSTAPTALPCDSGRQLEAARTLHGRNRSSFSQVHIKPEPLTDPLEPSLSSETTSLDQLRLEVTDYVTCLPISNLATNDVSVSEPMLEALKTEEAGTSTTADANTEPVDDDGVDECSAELSLAADGAKTFGDVCQPLQQPKASKVSQPMQQPQQEHQPKPPLTKPVKSRTSKEDGSYYPGQQIPVYRRGRSLSQEIVRVKGPSTLRAGAEVAPRLLCDNGNGGEGEEGPCSGHLARRRLRLRSERQQQLHRPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG49</accession>
    <name>A0A084WG49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP009807-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00017193</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023442">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG49"/>
    <dbReference type="STRING" id="74873.A0A084WG49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017193-RA">
        <property type="protein sequence ID" value="ASIC017193-PA"/>
        <property type="gene ID" value="ASIC017193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017193"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023161"/>
    <dbReference type="OMA" id="NHIKWIG"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000458">
        <property type="entry name" value="E2F-like (Mammalian transcription factor)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="428" mass="47959" checksum="0EDDBDB5BD1F34F9" modified="2014-10-29" version="1">MGKTADGCRKAVPKNGFQTFHAAFANFEGPVGAGKRRVDKSLTMLTNCIVKMLRNAPDGLLYLGDLSKTVSARQKRRIYDVTNVLEGIGLVMKQGKNHIKWIGSEQSSESCRDTAKAIGIHYKERRNLELCDTWFDAKIECMKKSIKIMLNDEASRSYLYVTSDDLSTTMDCNRRLLVLCESPDADPCAPRSLPTDDHWDAARRLKYTMEPISYTRKNRRLEVRANRGGPPIDLMVLQNPAGACFTRPSRRPAVLGRSANNTYAKLPDSCKQEPNVDCGQRAIEGKGQPSLDPPDGGESDTAANSTAKDSSNGDEAVNNDDNDDGVRRNRDQLARILLDDDEDDDHNHHRYSLYRPKGWIDKKNETRGLRMPFLLVEPPYYGSFHFTLGPTEGIFDLFDCDDVNRGCHSKAGRLVEDCGLPKIVEYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGA1</accession>
    <name>A0A084WGA1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yellow</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017345</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the pigmentation pattern of the adult cuticle and larval mouth parts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGA1"/>
    <dbReference type="STRING" id="74873.A0A084WGA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017345-RA">
        <property type="protein sequence ID" value="ASIC017345-PA"/>
        <property type="gene ID" value="ASIC017345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017345"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009126"/>
    <dbReference type="OMA" id="CENTYAY"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000046">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF12">
        <property type="entry name" value="LD43175P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784825" description="Protein yellow" evidence="7">
        <location>
            <begin position="31"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="474" mass="52839" checksum="726D8775349B1249" modified="2014-10-29" version="1">MVGGCSRAALVLAATVSCWLLVLLPHRALANDNLRVAYQWSEIDFEFASAADRQEALASKRYIPANVIPVGLEVYKKRLFLTLPRWKDGIPASLAYINLNETTTQSPRLHPYPSWSAHRRISESEAPEIVSPFRIRADRCGRLWVLDTGVEELLGNTTVSSPTSLLVYDLHNDNLLRRYTFPADHLKENSFYANIAVEDTVCEDTFAYAADLGSPGLVVYSWKQQESWRVKHHYFHPDPLAGNYNISGINFQWDDGLFGIALKPQPDGYSTLYFHPLSSLNEFSVSTKVLRNQTYATDAAANYHEFKVLGSRGPNGQAGVAFVDQKTGVIFYALPNLNAVTCWKTSNRAYTIKSLGRVYMSTVDMVFPNDVKVDDESNLWVLSDRLHQYMYESLNRNDTNFRVLTATVKDAIQNTACDTNIRPLPDIITNLGDILRPSTSTVAPKSGSSGAVKLQSIVGVATALAILATMLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGB2</accession>
    <name>A0A084WGB2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Allatostatin CC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023502">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017366-RA">
        <property type="protein sequence ID" value="ASIC017366-PA"/>
        <property type="gene ID" value="ASIC017366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017366"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018740"/>
    <dbReference type="OrthoDB" id="7464898at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784728" description="Allatostatin CC" evidence="2">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017366-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21261" checksum="EF61CC3A7C63F9D3" modified="2014-10-29" version="1">MRGVLLQMTLCLVLLEMPNVWGKLASYKGIVPPAKLSRSDEMAKYAVVNYDDYPMVVPKRAAMLLDRLMVALHHALEKGDGEDGGSRPINKVYRDGRYSGKPTVAKSLPIPPPPPPSKTEQLMKTYYAEADADADAEDRVTNSIPDEIDDIEARKELLDEMMDIQTRGTEDKTKKGRYWKCYFNAVSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGC5</accession>
    <name>A0A084WGC5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017381</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017381-RA">
        <property type="protein sequence ID" value="ASIC017381-PA"/>
        <property type="gene ID" value="ASIC017381"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017381"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13082" checksum="97831D4695755845" modified="2014-10-29" version="1">MGKQAANRRHRRAPIPAQFSPPNRKPAHSRSAACGKRREKRSLQIELSRYVAAASIGKTTGVESAHVAPPEGRQFEPLFRAKCVKAGRSKASRFFFLTARENNGQNENSSAKSACDTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGR7</accession>
    <name>A0A084WGR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP011608-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023696">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGR7"/>
    <dbReference type="STRING" id="74873.A0A084WGR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017513-RA">
        <property type="protein sequence ID" value="ASIC017513-PA"/>
        <property type="gene ID" value="ASIC017513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017513"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022628"/>
    <dbReference type="OMA" id="HWIQQQF"/>
    <dbReference type="OrthoDB" id="7726766at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784922" evidence="6">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017513-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="305" mass="32201" checksum="5810252444515B3A" modified="2014-10-29" version="1">MGSKGFRPMVFLALLALASAAQLDDANPFLVGGVPAAMGQFPAQVAVHIGTTSFCGGSILNQNHVLTAASCVLDANNNLVAANTVTVRAGVLLIDANAPALAVQRIFPHQQYNPWTLENDIAVLRMLNNFNFPLLPQPNMAPAEMNHHIVRLGATCHVVGWNWQQGGPNVALQVLPVLFADREACNAVHNGVLRDSMACTSYQQPQGTQGVCAANRGGGMYCDNLLTGVISFGFGCGQNNSMTVHTQTRYYNHWIQQQFIRTDTPVAGPTPLPGLGGTGQGGDASSFSLSLAAALFAAVCALFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGU3</accession>
    <name>A0A084WGU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00017541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB49437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017541-RA">
        <property type="protein sequence ID" value="ASIC017541-PA"/>
        <property type="gene ID" value="ASIC017541"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC017541"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:secretory granule membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
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        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:norepinephrine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF40">
        <property type="entry name" value="MOXD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="212" mass="23453" checksum="850D1616772CA3AF" modified="2014-10-29" version="1">MSAQNRKVKSVRSLSACAVVVLVLCCGGASGASAAGGSVERWEHLVDFDPNFRLLWSVEGQEVTFEMQARTLGYVGVGFSKDGTLAGADLVVGWMDDQGHAHLQHEHNNTALKRAGRLGQRASKRAGPGQWPTSADNHDKQTYGRRHTKHDNSLAGSVVDEVARRFVHRFSQSRTTKLKRSKGRWTLVTANEWQTFAEFYRESTNVRLSDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHC3</accession>
    <name>A0A084WHC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007955-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017632-RA">
        <property type="protein sequence ID" value="ASIC017632-PA"/>
        <property type="gene ID" value="ASIC017632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002460"/>
    <dbReference type="OMA" id="KVRCIEQ"/>
    <dbReference type="OrthoDB" id="8054697at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="119"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="372"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="372" mass="41227" checksum="836DA68DA79FF386" modified="2014-10-29" version="1">MRSRTEMVTTTLDGSDFEEDSDFEDSEEDWKPEKGDPKGLKRKTRDIITGTVSGGRRGSGGRSSNGKKRGRKPAAKGRAGRKRKSGNLSDDDDDEDEDDDEDDGDDDHSDSDEGERTTPRARKRGRPSGAKGAKRSNGRKSLAKTSPSTSKAAAAAASGGGELAVKPIPRKVVNLASSFPDKSGFLKLYAYRGDLEEGIRDNLKVCLWRRDGSSLLQKYFRDKSADASSPQFISSMVYSCWEDKRSDEYMEVKVRCIEQSKQLRVQIYDADTIEKKAKEEYEKFIVEHGKPILTAGGAGNRTNGNGSRSRKKKRAANNDTEDDEEDTAEEEEELEEEQEDEEGGGEGAPEEEDDEANADRLEEECEEPPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHD9</accession>
    <name>A0A084WHD9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017650</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC017650-PA"/>
        <property type="gene ID" value="ASIC017650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017650"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784784" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017650-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7720" checksum="7281D1BF8C625618" modified="2014-10-29" version="1">MMRRETVLRLGCALLIFVGAVEAHGHGQGSVETLLAHDLSSHEGPGDNFNNAFRAMENDIMKTTFIAGYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHU9</accession>
    <name>A0A084WHU9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017810</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB49793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017810-RA">
        <property type="protein sequence ID" value="ASIC017810-PA"/>
        <property type="gene ID" value="ASIC017810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017810"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="14254" checksum="47584CA2543D7426" modified="2014-10-29" version="1">MSLRFPFRLAMAMVENRRIKTTTTTAMMMVNGIAGVSSPSEDRLEGGPCLPAGDFLILIENCHQQKQCVLNQQKSKPTPEDEGVLSYKPKMKSGYGRKRDQEGKPVAQAKRWWAEEEEEEIHAKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIG4</accession>
    <name>A0A084WIG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018050</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018050-RA">
        <property type="protein sequence ID" value="ASIC018050-PA"/>
        <property type="gene ID" value="ASIC018050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018050"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15193" checksum="F18EF54C53B6A88E" modified="2014-10-29" version="1">MNYFQVSECLTDDLGDSPQRARIRVIPGAWWELAGVGGGREVSDYFRWLFFTFPAVHEAHGRIMTDDRGRRTIASRSPVGRVGPLTSLFFALTLVPPPPWSSLATCRPLSNPPCHFFEAPLTLTAGAARNVCLFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIP4</accession>
    <name>A0A084WIP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VEFS-Box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00018140</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIP4"/>
    <dbReference type="STRING" id="74873.A0A084WIP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018140-RA">
        <property type="protein sequence ID" value="ASIC018140-PA"/>
        <property type="gene ID" value="ASIC018140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018140"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008744"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21551">
        <property type="entry name" value="VEFS-box_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21750">
        <property type="entry name" value="ZnB-Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057540">
        <property type="entry name" value="Znf_SUZ12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23320">
        <property type="entry name" value="Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein SUZ12-like zinc finger" evidence="10">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="9">
        <location>
            <begin position="567"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB50088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="800" mass="90008" checksum="E6FA43E1691CC058" modified="2014-10-29" version="1">MERHAMKHANGSPTEGSSNAPMASGNDTANGKTKKMMPKRKEKEGELVYKQSKSEFLQTEQEIFLQAFERIFDKKNGATRITTDAVDGAFDDEPEGQKFSSRRYGLVETFLLKISHNKRKDISSTLKQVSFGKTDVLINPKADQTTTRDFDDKPPVVHIPTESFRYLCTPNHVAGPQLSILLLFRVHLKVSPTATNGNGFCDAAGNGHIKAEPSSDGEEPSAKRQKLHTITKLLTGELNIWGKEGPIKLQEGDYELKLREMVPQQRSFVAKNNSQPRNWNSEGIEMMDYEQSDDCSNTSRNDEQAEQELKDYFEEFRKHPRLKFRVQWTKDSECGVAELSAVGNGCSDKENYKPPSSPSESFKKGLNININNNSILTPAAASGRLNEVEQDQSSSDGSDLPPNNVQFQPDSNALVPTSSSSIGGEGRISDIAGLENGHEVKRVIYQLIHNNYTRQQTETTKFTCPWCSLNCCILYSLLKHLKLCHARFVFNFVPIANGARIDVSINELYDGSYNGSPHDLLGPTIGYTRRGPVRRTVVTNLLVCRPRRQKPSLSEFIDTDENEFDSQRPYITGHSRMYHHTMTCLPVYPRELDIDSEGESDPLWLQHKTMQMIDEFTDVNEGEKELMKMWNLHVMKYGYVGDCQIPIALEMFIDMRGRELWARNLYRNFVLHMSSMFDFGLVSADVMQRTIRKLRKILLNDAELQQQIRQSREQQMSYWNNVTVHKQAQKTEARNGVGERTLGAGASSSSGSSLASYHKAVHGGSNSGPASAGDGQQRKVKPTITPAKNTDPSGGYTFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIT1</accession>
    <name>A0A084WIT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018182</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023945">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018182-RA">
        <property type="protein sequence ID" value="ASIC018182-PA"/>
        <property type="gene ID" value="ASIC018182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018182"/>
    <dbReference type="OMA" id="CNDIDAD"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018182-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="27275" checksum="1809C56E05340EED" modified="2014-10-29" version="1">MSSSPRLTGYTLRPSETSTTVSITLNSCGTGIKKLSIKSAGSTNSGGESTDPLESDFSGEEEEEQEVSGEEEGDEEEDEDRRKGESVRSRLVKGHKKDKKAKAEEKDEEEEEEEEEAESNSDNEKDLRHSSAPKLVSNRRQKSASSADDDDDDDDEEDEEEDEDEDEPERRNPGQQVHRNVPGSRQQPRTPAADADDGDDSRCGGDSDDDGGDLSDKNNNIGGAVRRKQPEDYALDDFQILKTIGKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIX2</accession>
    <name>A0A084WIX2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alanine--glyoxylate aminotransferase 2, mitochondrial</fullName>
            <ecNumber evidence="28">2.6.1.18</ecNumber>
            <ecNumber evidence="12">2.6.1.40</ecNumber>
            <ecNumber evidence="5">2.6.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(R)-3-amino-2-methylpropionate--pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-ALAAT II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-alanine-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">D-3-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">D-AIBAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">D-beta-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="ORF">ZHAS_00018229</name>
    </gene>
    <organism evidence="40">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="40 42" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="38">Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77339"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:18393"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.40"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18394"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77355"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77363"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77359"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>3-oxopropanoate + L-alanine = beta-alanine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:14077"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.18"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:14079"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77331"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77327"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77315"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77307"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:77351"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77311"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:77343"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77303"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77323"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77319"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>oxaloacetate + L-alanine = L-aspartate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77347"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 39">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="28"/>
    <dbReference type="EC" id="2.6.1.40" evidence="12"/>
    <dbReference type="EC" id="2.6.1.44" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01023952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIX2"/>
    <dbReference type="STRING" id="74873.A0A084WIX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018229-RA">
        <property type="protein sequence ID" value="ASIC018229-PA"/>
        <property type="gene ID" value="ASIC018229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018229"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018811"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047305">
        <property type="term" value="F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine:pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019481">
        <property type="term" value="P:L-alanine catabolic process, by transamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000055">
        <property type="entry name" value="Alanine--glyoxylate aminotransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF3">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 40" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 39" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 40" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00044055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00058068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KFB50166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="472" mass="52704" checksum="05643C1EE915A35C" modified="2014-10-29" version="1">MHPEPPVYKGQTYDHISNLRKQYLTPNVTSYYKKPLLIHKGNMQWLFDHEGKRYLDMFGGIVTVSVGHCHPKVNAALEEQLRTLWHTTNIYMHPKIHEYSEKLVARLPGNLKNVYFVNSGSEANDLAMMMARLYTGNSDIISFRNAYHGASPYTMGLTAHSTWRYPLPGVNSGIHHAMNPDPYTGIWGGQHCRDSPVQTTRKCDCMESGGKCKASAMYYDQLEQIFKYSLPRGKVAAMFAESIQGVGGSVQYPKEYIKRAADLVRANGGLFVADEVQTGFGRTGEHFWGFEGHDVVPDIVTMAKGIGNGFPLGAVITSRKVAEVLSQALHFNTFGGNPLASAVGMAVLDVIDEEELQKNSLEVGTYMLKGLERLRDKHDVIGDVRGKGLMIGVELVADKESRQHLSAPHFVDIWEMCKDMGVLFGRGGLNANVLRIKPPMCINRTDADYALAVIDYCCEQHMKKRKRGCRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ13</accession>
    <name>A0A084WJ13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP012057-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00018275</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023960">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ13"/>
    <dbReference type="STRING" id="74873.A0A084WJ13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018275-RA">
        <property type="protein sequence ID" value="ASIC018275-PA"/>
        <property type="gene ID" value="ASIC018275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018275"/>
    <dbReference type="OMA" id="MPTFENI"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000001">
        <property type="entry name" value="RNA polymerase-associated protein RTF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="10">
        <location>
            <begin position="172"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB50207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="519" mass="58605" checksum="616FBE80A8A927C0" modified="2014-10-29" version="1">MQNQLFPSVSSASEYFDPKERSKERKKTVEMNRTDDKRSNAMAMLKAKREGKAKREEEEAKREAQRKQDANQQEDKEELDDVPGGKSQMKLKASDIYSDDSGSSDDDDDGDKKSGDRRSRSGGSGGSGSGSDSRSSSDSEGEDKEKKSGSGSGSGSGSGSGSGSSSRKPVQISSNAELNKLRISRHKLERFINLPIFEPTVMNCFVRINIGNNQGKPVYRVAEIVGVVETAKIYQFGRSRTNKGFKLKHGSQERVFRLEFVSNQDFSDTEYQKWLTVCASTGTPLPTVDMIERKQRDIKEASMYEFKDADIDRLVEEKNRFRAHPTNYAMKKTILMKERDAAQLRGEDDLARELNSQIQEIEERASTLDKKRSSSISLISYINDRNRKRNVEDAEKAIMEEKRAMRGQKIEDPFTRRQTQPRMSFKKDEKRDEPQMMAMLAPPPPGLGKKKQEEKKPNHGAGQADNNLYSLHDFDIDLEVPLPMGPVNVLPKPVEKPVRESGPKRSLNLEDYKKKRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJP3</accession>
    <name>A0A084WJP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005770-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018467</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJP3"/>
    <dbReference type="STRING" id="74873.A0A084WJP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018467-RA">
        <property type="protein sequence ID" value="ASIC018467-PA"/>
        <property type="gene ID" value="ASIC018467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018467"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002900"/>
    <dbReference type="OMA" id="CPDTNEM"/>
    <dbReference type="OrthoDB" id="525027at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="682" mass="77640" checksum="A21BB9D177228F7D" modified="2014-10-29" version="1">MVKMASTEEQDRKIVLEFCHLLEKSKQLFNGLRDLPQYGHRQWQAYFGRTFDVYTKLWKFQQQHRLVLDSNKHQLPETAYLAMFGHLHLPPSRQPSLIECFFFSLSLAYVYSSLRTSETNYLNEAYSFYAAIRGRAYYSRAIKEDRPDLMVKKLRYYARFIVVCLLLKKMKLVRELVIELERQIQEYTTTYEPEDQLEWSLVLEEIKGFIKAESAVAVLHADTNPIVLSHRLSPLTTPPCERTPHMTLSLQEILIVGSACEQAKFSELTMDMFRMLQTLEREPTDSMHPMIGHPMAHGGPHDASPAASRMPPYGVPGSKGYVENGDRRSMRDNPHKYLLYKPSLSQLMVFLSSGFKELPPGGALLLYMSADGCFSTTKHPQDYGYELGGLATSVKRDAVDSGLSVRGKSSAGYKEPHCLYPGDLYPYTRRPLFIIIDSDNSFVFQHIPRYFGQPLVILMSPQDVPANYQDLQHHGSLFTLFLHSPMTAMCYICNVGDVPIHHWERCQGYVDRFVTEASRLVTRCRMDEIEQGIGYIDSSYVQFFGDDFLRTLILRFVFCDVALRLHRGFRGRHQRPRCEPPCPGRSCSSIHRWRTSCSSWPPPSTSGLPASGGTVRPTVELLPRFAVRDRLLIGRLHVFSSAVAVMVVTLMTTLVPSVAAKCRRASTPTVSVGVVRVVLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL74</accession>
    <name>A0A084WL74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006190-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019010</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019010-RA">
        <property type="protein sequence ID" value="ASIC019010-PA"/>
        <property type="gene ID" value="ASIC019010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019010"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003944"/>
    <dbReference type="OrthoDB" id="6624193at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019010-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="399" mass="42750" checksum="9F0EB3ED0BD47188" modified="2014-10-29" version="1">MIYQVSPATRRTKSFDDQAWKIHDETANLSVNISAISTTALATRTTRMDSDVESLGGAHQPRPLATGLDEVLVVSEGPSSDACGSLSRGEVRKSRSKMKSYLKRCKDVLIGGVSGGAQVGVATSTATSSGQEEVVVYHAHGGEQSQPSSTSCWYLDDQLMELRPEDNREPYSSLASARLKQELEETRLAREAISEERSDSGVPTVSVTTTVTSTTSSTMARIGEGGSGGDNVHGLSVIENSASGNIALETYGTDVEEPMMEKERLMIVALSVRLTLIKFRNGAATNPSGSRVPKTPARVSQPAFPTSPHEGPNKNRKGSTRQSPASNQRRAAFAAAFGSSYPIGRIGSDRSKSKVQKICVLRVLPVGSIAENVNETNELGCRMVWSCWLLVAGMLRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLF9</accession>
    <name>A0A084WLF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007471-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLF9"/>
    <dbReference type="STRING" id="74873.A0A084WLF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019106-RA">
        <property type="protein sequence ID" value="ASIC019106-PA"/>
        <property type="gene ID" value="ASIC019106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019106"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016808"/>
    <dbReference type="OMA" id="IVANIRI"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="617" mass="69217" checksum="C6DECD5A2CD32644" modified="2014-10-29" version="1">MDLSDNKINLLIGTNHTVSIETLNIAHNRLTSLDLTFFGQIANLSVLYLVHNQIIRIDSTTPVKLLALEQLMLSNNQLTWFQPQAVSFPALQKLFLNSNNITFIPRNLANYPALEILNLRVNKLTRVDLSSVRQAKKLVELDLSGNKITSLSTPSPLKHDGLQVLIVDNNELVQVNFTGCTFPNIRAISLAHNRLTSVPSNVFQLFPTVLLYMYDNPTSCDIHILWTKLSERFRFAAECVSFVITISGTRYGDLMMPRYNWLMVHMYLIKFQIENQQIPNGFGWYFLSFLHTLLTGLLGNENNPSPCTIPRVNTTDNGWAMGIVAGIELGCSSITIENVSLPAAPGALAAFIQVISSLTVQLVFEKYYERGFNLTKALTAEMIRIGSSSMLEEMQIQPNVNIRQLTMLYTSLTHLPEGLRSLPKLDKLETPGNRLSQFSLTSFSSIQKLSYVDVSDNRITNYATLTNLELRANKLTRLDLSSLRNAKNLSVLALDGNRIASLSTSSPIKNDAIVHIGLDRNQLQQVNFSGCNFPNFRYLFVRQNQLTSVPLNVFQQFPSLTMYMSDNPLRCQDLAKYKQQLVGGALAVDPIRGDTKCLENQSSSIKVNDHQKICCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNP1</accession>
    <name>A0A084WNP1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019992</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024644">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNP1"/>
    <dbReference type="STRING" id="74873.A0A084WNP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019992-RA">
        <property type="protein sequence ID" value="ASIC019992-PA"/>
        <property type="gene ID" value="ASIC019992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019992"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006600"/>
    <dbReference type="OMA" id="PAYVCHQ"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="24697" checksum="306E418039E27679" modified="2014-10-29" version="1">MANYLANALKRLSISHNVTTGAAFRVLAANLHTTTPLAKNWNGRNTGPQRWMQYNKVIYPPQAPEEEPRPAYVCHQKTNIKYSPKKMWYVASFVRGMTVDEAVKQLSFVDKQGAAYVKEAILEAVDMAVKKHNVEFRSNLWVAESFCGKGRVFKGMRRHGRGRTGEVEYKHCHYFVRLEEGAPPQNYYQMPPKTGEQQLDDWVDSMRKRKVTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP89</accession>
    <name>A0A084WP89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020214</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024983">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525366">
        <property type="protein sequence ID" value="KFB52033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020214-RA">
        <property type="protein sequence ID" value="ASIC020214-PA"/>
        <property type="gene ID" value="ASIC020214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020214"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8361" checksum="1A57659A7A799AA3" modified="2014-10-29" version="1">MWKTNEKQQTANEVLRVLGALTARAHVCCGGKTGSPDWRLASSSVVASDRETRSMETDATRGNGVPAQPHQAAVRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPB4</accession>
    <name>A0A084WPB4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00020244</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525367">
        <property type="protein sequence ID" value="KFB52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPB4"/>
    <dbReference type="STRING" id="74873.A0A084WPB4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020244-RA">
        <property type="protein sequence ID" value="ASIC020244-PA"/>
        <property type="gene ID" value="ASIC020244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020244"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017781"/>
    <dbReference type="OMA" id="ESIWRAE"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020244-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="199" mass="22573" checksum="C39767BD6C955384" modified="2014-10-29" version="1">MAIAKATTIKEALKRLEDRTKTNSCDEKEIDLCFQWPPIEKMDTTFSTLTACQKLSLSTNMIDKIYGLSGMKNLRVLSLGRNYIKAISGLEGVSDTLEELWISYNLVEKLKGISVLKRLKVLYMSNNLVKDWVEFNRLADLPVLEDLLFAGNPLVESMEESIWRAEASKRLLSLKKLDGETVIREETENQNAQGAQPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPI6</accession>
    <name>A0A084WPI6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP000533-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020453</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025080">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPI6"/>
    <dbReference type="STRING" id="74873.A0A084WPI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020453-RA">
        <property type="protein sequence ID" value="ASIC020453-PA"/>
        <property type="gene ID" value="ASIC020453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007356"/>
    <dbReference type="OrthoDB" id="6412801at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16522">
        <property type="entry name" value="RING-HC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB52130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="623" mass="67056" checksum="7A4E79AE8188B815" modified="2014-10-29" version="1">MRCAFGGSSGAAAAPQQHQSTRIAMNPTSLYITTSRLVFQGNIVEELPDLNRLLPYLRKSLSCVVCCKLLVDPHSPSAAGCQHHVCRVCVGKRKKLKPACRFCKDLFLYRENTQLRLILQCYKGICSYIRSRPIYEEIRNCASVQAEGGATGNVGRGRAPGRSNGTPGSLMDLIEEGATFQDDFKCNSGLTKSAYSILPCIYPAPSLNALSTSVGGAIPPALLPVVPPISAVATAPSNKGSPSTQAQLVPSVAGPSARKTAKTYKQPSAAAPPKAANEQPSELTQSLPAQPTTELKNNRALRTGAEKPPKPATQKRKQQQQQPNPTASKQMKAGEHLPESEKMAKPPQQEKQPVPVLEQPKEAVQPKQQKQAKQPKEAKETKRRKAEQAPQKRAKQQPEPPESLPQQSKGKVGTNKKSKTVGEPRSQPISLPTPPQQNQVQVQPNETQQQLLECKPDPELIKPHPPVQKEQQSLYGTLYRHAASFMPIPRGAPRCLARPSPPCRRYRIVKNTCTPTTPRIVNITTPQEIKFQPAPIKTVSSGSTMYSVVYAESGNKVTIKRKPDPVSVAKGATSAKMPSKVVNIGAVSPRVPVSGTALAMTTIPAPASIASAGAAETLIAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQC9</accession>
    <name>A0A084WQC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Lauroyl/myristoyl acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020668</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025520">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525392">
        <property type="protein sequence ID" value="KFB52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020668-RA">
        <property type="protein sequence ID" value="ASIC020668-PA"/>
        <property type="gene ID" value="ASIC020668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020668"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020668-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="11918" checksum="E55F53BC13D42908" modified="2014-10-29" version="1">MGCDRAAKLSTGAHVSWTTRPERSALTEGSAEKCATQGTQGGGTRQCWSGSGDTSLDTVDISLGFSAKPDAFSLATISRKWPLRSLRFALDDRTKPAVIERGRKVGLFHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQE7</accession>
    <name>A0A084WQE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP001483-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020677</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525394">
        <property type="protein sequence ID" value="KFB52441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQE7"/>
    <dbReference type="STRING" id="74873.A0A084WQE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020677-RA">
        <property type="protein sequence ID" value="ASIC020677-PA"/>
        <property type="gene ID" value="ASIC020677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020677"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009604"/>
    <dbReference type="OMA" id="CSQSYQF"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000066">
        <property type="entry name" value="Paired mesoderm homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="183" mass="20394" checksum="7DA2AFFE1C84153C" modified="2014-10-29" version="1">MKINSSSQKKPRRNRTTFSTNQLTALEKIFEKTHYPDAFVREELANKVGLSEARVQVWFQNRRAKFRRNERSASSGGGAGGCKVDELYQPSVIPPAGGGVGFGLDKSNAPYSVSFSTLSSIFSPVVSQLQHHHHHHHHHPVAAGATRGSQLFPSYTQQHEDASFNASSYQFPNLKYLNNLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRM6</accession>
    <name>A0A084WRM6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021143</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRM6"/>
    <dbReference type="STRING" id="74873.A0A084WRM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021143-RA">
        <property type="protein sequence ID" value="ASIC021143-PA"/>
        <property type="gene ID" value="ASIC021143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021143"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019744"/>
    <dbReference type="OMA" id="CLMNVGC"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000012">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1187"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="311"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="681"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139743" checksum="A83FDBC2A3210F39" modified="2014-10-29" version="1">MSRRDNNVRKLSFLGFHTKETSNDDPNEVHLDDEIERVFGSASGTEKERFELNRLKDDVILDNSPLKYDEAHRVPDKSDSSRPAQLPGTTRQMHQPDTASSASNVSNGGHGAKSPPTTTPTSPISFSSKSETTTTANNATLADNTSNDFSETVHDEPIVDQGTVQGEQWDTSARRNVHFDKDKKGAQIEGLPLEDTNEERRRRTERHHPHKSRKFSLQEYHPEWRRQSGTEGGPTGRRISVQPEDATLQEADIDELTSHRSDDPRALRRHKVSAQSVTSMVNINRKETGAPPLQQLLPLGKYKKLYDHSPHEVFVQLDELTGSGEDREWKETARWIKYEEDVEEGADRWGRPHVASLSFHSLLNLRRCLETGVVLMDLEEKDLPSVAYRVVEQMVIDELIHEDDKPVIMRALLLRHRHVNESSHGGFSFGPKRKYSSYTSLQSVDDKKPRIVPSAEINGHGGHGETRININEETYTATSSQEDIKMRTQKESILKRIPEGAEATTVLVGAVDFLEQPTIAFVRLAEGIPMPSITEVPIPVRFLFILLGPQKTELDYHEVGRSIATLMSNEHFHDIAYRADDRRELLSAINEFLDDSIVLPPGKWERQALLPFEELKAKSDMIRLRKKKALDAKMKSKQSGELQLTGDEEKKLLAAAADAAAGGAGGDGKKPKKNPLEKTNRLWGGLINDIKRRYPMYKSDIMDGLNTETLAATIFMYFAALSTAITFGGLSSDKTHNLIGISETLVSASLVGLVFHLLSGQPLVIIGTTGPLLLFDEALNQFCIANGFSFLTVRVYVGCWLAVIALVVSAFEGSVYVRLFTRFTQEIFSALITLIYIVETAMKLVSVYARHPLLAEYLYKNVTVAQPVPYVADGNDTTTSGDGLLAESLTSAVNATLGITSDAGLLLPEDNIGPINRPNTALFCTILTLGTFSLAYYLKMFRNSHFLGRNARRALGDFGVPISIALFVMVDFMLPQVFTEKLSVPEGLSPSDETRRGWLIPLGGVPGWLPFVAGVPALLVYILIFMETHISELIVDKPERGLKKGSGLHMDIVLLCFLNTVCGFFGMPWHCAATVRSVTHVSAVTIMSRNHAPGEAPHIADVKEQRISGFFVSLMVGLSVTMAPILRLIPMSVLFGVFLYMGIASMSGVQFFERLRLYLMPVKHHPQVPFVRRVPTWKMHLFTFVQILALAMLWAVKSSPFSLAFPFFLIMMVPIRKQMEKFFTPLELRALDGSQPNEGAEDEPDFYEQASIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTN1</accession>
    <name>A0A084WTN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013209-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTN1"/>
    <dbReference type="STRING" id="74873.A0A084WTN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021810-RA">
        <property type="protein sequence ID" value="ASIC021810-PA"/>
        <property type="gene ID" value="ASIC021810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021810"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007612"/>
    <dbReference type="OMA" id="YQTHHEQ"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="426" mass="49371" checksum="2CE2E27E7F3DFA24" modified="2014-10-29" version="1">MLKLHYSSKLFKRYLSSALYLTGDKAREQFAVLVPYLDFKHKLGDFERLKRNVRLREYPLDCDNLKLQWDLYRDVEKRKQDIERCRTELQKRIQQSTDEEEKKALKARAVQARDDLKMLKERSYAVADAFIANNFLAIPNDLHERTPEDSGKVLHEKHAPPTGKSSGQNNLVEEQFEQYGPSCLYLTGDAAWMDLRLPMRCCETFQEQKYILFCNPDFVRTFLLEAAMVPKDSLYLVREDDEPEDKVNLLHLCGGGSLLGFLGYFTKLSVFPSVLPLRLVASGKRYHFERTQSNEVHVFGACKTAQEAELLFDETVQHCRTFYDQLPVGYRIVQVAAPELQPAESMRVDVELYDEQEQRYVKVAHVCYLSDFLSKRIAFIYQDGKAQKFPHIVTGQVLSSVDLIKLLLRNGIRVKDLPFLDKFGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU43</accession>
    <name>A0A084WU43_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022116</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026996">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022116-RA">
        <property type="protein sequence ID" value="ASIC022116-PA"/>
        <property type="gene ID" value="ASIC022116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022116"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="24184" checksum="71075D5B1C228B6D" modified="2014-10-29" version="1">MIESFASAQRSRGPGLETGLGQRIGLARTVRLGPFQTMLGCGPVLNGRNNLNEHTTRTTRRLPNLANRSFEQPKPAGPRVFALNSAAPRNPISLFAPGRKRKSERDGASGRERRACSSRKCPRTVRCSVSVGANVRNTTQHRSRSGEPTTKCCADISNINFSLFCGSLKGFCSAPWKASHAQHACKRWMGGEDSSDAAANDDEDDADDCPIGHHRVPTLTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU85</accession>
    <name>A0A084WU85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027009">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU85"/>
    <dbReference type="STRING" id="74873.A0A084WU85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022013-RA">
        <property type="protein sequence ID" value="ASIC022013-PA"/>
        <property type="gene ID" value="ASIC022013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022013"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021097"/>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="338" mass="38129" checksum="35E637C560D36B25" modified="2014-10-29" version="1">MFDDKEKVLICPTCKQPCELLDGPCGVSQRPQHFMLAEKIENTIFQHGTKSTCTYPRWRTVQFCLSYDPSRLRKNQIVKKSPELKIALTLREFHSQNFGSTNVLAAVLHFLQGSPQTAAQHSLDPHGKSIKCPMHPEQQLKLFCTTCHQVICGECSTLLHRDHRCTTVARAGRVYGRFVRSAIEQTRPLEDYALQQVAKLNDLTVRINSRCEAVQREVDAFVGEYVAALEEHRKALTGQIGDIRQAKTDMIMAQKLDLGLLEVLCLFVDHEKLEHGGITVQSELRFRNDEDHSVVVCIANNQDGSNALCFVPNRAGMMHLILSVDGKIIEERYNSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUL7</accession>
    <name>A0A084WUL7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00022359</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cell projection</location>
            <location evidence="9">Rhabdomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WUL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022359-RA">
        <property type="protein sequence ID" value="ASIC022359-PA"/>
        <property type="gene ID" value="ASIC022359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022359"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014497"/>
    <dbReference type="OMA" id="WPLNFAV"/>
    <dbReference type="OrthoDB" id="6589456at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016028">
        <property type="term" value="C:rhabdomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF21">
        <property type="entry name" value="PROTEIN 4.1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="30"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1466"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022359-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1607" mass="175146" checksum="036970C2E540C1DE" modified="2014-10-29" version="1">MPGESAKAAEAAAATTPTTPKKKPSNTKAALAKVTLLDGSILEVTIDRKCRGRDLLNSVCAGLNILEKDYFGLTYHTANDPRTWLDLERPVTKFFRSDPWDLSFEVKFYPPEPAQLQEDITRYHLCLQVRNDILEGRLPCSFVTHALLGSYLVQSELGDYDPAEMKDRSYLKDFKIAPNQTPELLDKVIDLHKTHKSQTPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRNNFYIKIRPGEFEQYESTIGFKLENHRAAKKLWKACVEHHTFFRLMTPEPQQKSGLFPRLGSKYRYSGRTHYETRKTPVERPAPDFKRSLTGKRLSSRSMDALAQQEKERAAAKDPNKDANKRHTMSHPPDHIPDLDSPTRGSRSPIKKDKKERKPAGGVAVLPVVGKKDKPEQTPQKDEALNGNNGQAADPLNSSAEETTSPSGKRRGIPVSSGRKSPKEKKTPGGGQQDPAKQQQQQTTPEKPGFTKPYEYSESEQDPAAHKKNVKTRGFRYDEAAPLRGAANDEHEPQLSPNSQSRRATGLAFNYAPGEDQKVRESVEKRKTPGSPLVGVATKPTPDQLSPKSAARGLPGETDAEKGVRTSARSYSPNKGRTPVDPLASGAGTFRPLDDTSAAFIQGEQSGAAAAAAAAAAAAAAEPAKKKVKIMVIISRFDPKTKKVDTAQGVVEHSTGVLDTKTGQIESKYGLIDPKAGTVVNFNARTGQNETFQGQTDAKTGQLHVVGGVVDPATGKIDESLGQAITVVPDDDTVVEITTITSKVDPTTGKLDTTNGEIEKSRAILNQRTGVLSTKYGDINPRTGELRAIDPKTGRPSPAASAVRPVTVDRANGQITIVGVTDPKTNKVDNGQAHLVAIGNQVDPVVEVTSVLGKMDKKGIVDPKTVVIDKSTGQLDTKDGKINTKFGQLDLVKQTITFVDPKTGKTETKEIKVDPVTGQVMLKGGQVNPKTGKVDKDYGRIVSIRIVHSRIDPVTGKHVPATTVDDKDIRVDAKTNQVWIPDGGKDPRTGETIYTSSQVDPRTGFVITLYGYLNTKTNEIERQSKLDPNLTKVDPASGQVYAATGEVDERTGEPLFVATQINDENGEMYTKVGRVDPKTGRLVIIRIFIITKKDERGRPEEVDVTTVDMDPETGHIRNVAPKTLYLYKMRDPITGETYNVDPNDPRVAGARTTVTQTMTLSGEIDPVTGRIKSEWGHIDPNTGDIDPATAIKDPVTGKLILNYADIEPSHFGKNVTVTKETVPITREQFYEGIKHMGKTVTRRDSESSDDDMTAQYGSESIKEIHSGAGLAGKSAATTTPTVVKTTTKQVITKNEDGVTHNVEEEVQNLGTGQIVYSTQEHKADAPTGGADAGKFVTATAVTTRTATTHEDLGTNAKTQQLEEKTVATTTTQHGERQEQRVITQEVKTTATVTSGDQYTRRDSVSSTSSGDSGTPIDGPYGDESLSEVIYNKSYTGADNVAGASQIPEGPNVEHRRVLLEEGETTAHGEIVSSQTVSSKTRTVETITYKTERDGVVETRVEQKITIQSDGDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUS1</accession>
    <name>A0A084WUS1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022213</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUS1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022213-RA">
        <property type="protein sequence ID" value="ASIC022213-PA"/>
        <property type="gene ID" value="ASIC022213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022213"/>
    <dbReference type="OrthoDB" id="7733937at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14704" checksum="E75CC632B39CB729" modified="2014-10-29" version="1">MVQFEHTWIIEPSLLQPHCPRCEVVTGTVRWEINACLGGSQGTPGCTSCSGPFLHLVTGPSQTAMIGIREEGFDRKIYLPFEQYSLVSDEKLPLIVMDASSLSRPGRRKRRKVVCTFSMYVNISVDPTKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUT1</accession>
    <name>A0A084WUT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002636-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022226</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022226-RA">
        <property type="protein sequence ID" value="ASIC022226-PA"/>
        <property type="gene ID" value="ASIC022226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022226"/>
    <dbReference type="OMA" id="HNICICM"/>
    <dbReference type="OrthoDB" id="7730086at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785353" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10832" checksum="41FAF199B41BA68E" modified="2014-10-29" version="1">MKSTIAVLMLFTAVLLGSVDADCPELSEFTTSSTCEYICGKPCGLQTQTFKNICLCIEGYLKDPDTGKCIPEKDCKVTIPDNTPTLRNAEEFKFSCFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUY3</accession>
    <name>A0A084WUY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002796-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00000535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01002760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL640906">
        <property type="protein sequence ID" value="KFB54027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUY3"/>
    <dbReference type="STRING" id="74873.A0A084WUY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000535-RA">
        <property type="protein sequence ID" value="ASIC000535-PA"/>
        <property type="gene ID" value="ASIC000535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000535"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015282"/>
    <dbReference type="OMA" id="WANGTIM"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB54027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="187" mass="21049" checksum="575B64D32EA8ED04" modified="2014-10-29" version="1">MESRGNLDYSVNGEPLGVQHTGSTLHFGPYPGLNGYEMATAAKVAPPGQGFNKDFHRYQLEWTPEFMKFSVDDEQVLQVNGNFWELGQFQQREPNAANPWVTGGKMAPFDQEFYIIMNLAVGGTNGYFPDTPPAVNANGNKPWSNNAETGPRDFWNARGSWLPTWKLEENESREASLLVDYVRVWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAQ1</accession>
    <name>A0A084VAQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002506-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00000865</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01004135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAQ1"/>
    <dbReference type="STRING" id="74873.A0A084VAQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000865-RA">
        <property type="protein sequence ID" value="ASIC000865-PA"/>
        <property type="gene ID" value="ASIC000865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000865"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024348"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF49">
        <property type="entry name" value="PROTEIN LOZENGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000865-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="291" mass="31562" checksum="457513A41A8EA517" modified="2014-10-29" version="1">MSLVTCAARLQCPLPESGEVAENPKCTQDGGGGRWRNSTGTYGTGRRKQVAAVGVVGNIMLEASTGDGAGNCRTNTSSSSVTSTSVANNGSNSNSNNNNNSHSSSNLNADDSSVSADLRWIERMVMDAEQQYPGELVRTDSPYFLCSALPHHWRSNKTLPSAFKVISLGDVSDGTMVTIRAGNDENFCAELRNCTAVMRNQVAKFNDLRFVGRSGRAHGVDMTTPCKDRICYPNRGPISSGCFVSGRDRLGRVFLFRSTFTNLVQNYCSTCINHMLVVIHSAEKRPFQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB97</accession>
    <name>A0A084VB97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00001384</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01006130">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524341">
        <property type="protein sequence ID" value="KFB35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB97"/>
    <dbReference type="STRING" id="74873.A0A084VB97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001384-RA">
        <property type="protein sequence ID" value="ASIC001384-PA"/>
        <property type="gene ID" value="ASIC001384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001384"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022716"/>
    <dbReference type="OMA" id="EYIHPIS"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="61"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="240" mass="27181" checksum="D4D3B6AD69109CDB" modified="2014-10-29" version="1">MLCGYLISGDGFQLGTCVFFTSECKEFQNLTALRSYILPLPMYALPIDVTSHSCKKVVQLIAGGEPAENGEFPHHALLGYKKIGTEREYKFECGGTLISDRHVLTAAHCFKSEYPSIVRLAVYDIEKDYGHEVPVEGFLRHPNHSHFNVYHDIALVKLENRVYFTPSIRPACLWDTERSNISKYIATGFGMNEHYEHSKNMMKVVLENYPENDCYERVKFLGSRFALGIQPGQLCAGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD13</accession>
    <name>A0A084VD13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010035-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002808</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524642">
        <property type="protein sequence ID" value="KFB35857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VD13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002808-RA">
        <property type="protein sequence ID" value="ASIC002808-PA"/>
        <property type="gene ID" value="ASIC002808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002808"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009492"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of cell growth"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Raptor"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="113"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002808-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="335" mass="36413" checksum="60F34F9960A115DE" modified="2014-10-29" version="1">MHLFATVSNDMSPLVRMELIAALQWMVLFFETQFVATLQMADSPERAGTNPMKRVSSTNNIIGNVGKASVTVGIYQKLWNGFVSLSKDPFPEVAVMAQKVVDYVRAETAKEVTVCDRSGSSSGHYSSASSVSLPPSPNTRVNYLTGESPPTGHGPTDNGGHRIVGNHHHHNHPHHQTPLALKRRVVHALNESSDFSSGENSTATASTATVGPTQTSSSFTSGPSAASVAGAGAAVPLKPIVGTKFIEWSVSFFAQPSKHMHDTKEAGGGTASTDHNSYEFLNRQSRRARNQTVRMEGRAQRKKAIFKRLDXXXXXXXSRFDNNNRQIGRDWSKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDW8</accession>
    <name>A0A084VDW8_ANOSI</name>
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        <recommendedName>
            <fullName evidence="2">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003224</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDW8"/>
    <dbReference type="STRING" id="74873.A0A084VDW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003224-RA">
        <property type="protein sequence ID" value="ASIC003224-PA"/>
        <property type="gene ID" value="ASIC003224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003224"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002200"/>
    <dbReference type="OMA" id="NAGWADC"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003224-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="296" mass="33653" checksum="ADCE2456C2EF486F" modified="2014-10-29" version="1">MLKVAKKAKATPLPAPESDSDSADSSADEEFLSDAEYPMSEDENAGDNIEASDDETKDRDESRGPTKWAKAMAKFLRKTTDAKILSKATTEAEIERKKKESSTYKFEVVGQEGTVKKEGQEDKPDDIELMRELLRQKALLKKERRKDILGLRVRPTIGDYERERTLRKVATKGTVQLFNAVRKQQKEVNRKLEEAGKLEYKREKVLKSLSKKEFLDALMNGPRAKSELVDNLVKKEEDEDVDEDVKSEVDSDEEPKSTWGPLRADFLTGKKSGWDKEYAEDERNVPDDLDDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDY8</accession>
    <name>A0A084VDY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006899-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003265</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC003265-RA">
        <property type="protein sequence ID" value="ASIC003265-PA"/>
        <property type="gene ID" value="ASIC003265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003265"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012633"/>
    <dbReference type="OMA" id="EIIHKMM"/>
    <dbReference type="OrthoDB" id="7762393at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783587" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11740" checksum="B35B6E7AC9C93DDE" modified="2014-10-29" version="1">MTSKWFPLLAVVALHLVSAAPLGGNSTELSKTIGVIHHLTYLIDYLVQYVIKDNDRKTPKDAADYYQKALVEGQSEGAVRDSEEYKPSADRARQETEIISKMMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VES4</accession>
    <name>A0A084VES4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP013420-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00003508</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012290">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VES4"/>
    <dbReference type="STRING" id="74873.A0A084VES4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003508-RA">
        <property type="protein sequence ID" value="ASIC003508-PA"/>
        <property type="gene ID" value="ASIC003508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003508"/>
    <dbReference type="OMA" id="PTMIKIS"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="21573" checksum="01AB3381B9DF7DC7" modified="2014-10-29" version="1">MNKPPVPDVRCTAYISNLPFDLTNIDVHKLFSKHGKIVKVTILRDKTTRKSKGVAFVLFSTPQEALECCNASNNTQMFGRTVKASIAKDNGKSADNAQRKHYPDKSRCFECGDEGHLSYSCPKNVLGSRTPPRKSGGNRAKRKQRSAESESFGGTSEPEEAPLWNADSVPIPVKKVKYKKSDYFSDDEELEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEW9</accession>
    <name>A0A084VEW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003648</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524783">
        <property type="protein sequence ID" value="KFB36513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEW9"/>
    <dbReference type="STRING" id="74873.A0A084VEW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003648-RA">
        <property type="protein sequence ID" value="ASIC003648-PA"/>
        <property type="gene ID" value="ASIC003648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003648"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005122"/>
    <dbReference type="OMA" id="RGYPLMG"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15957" checksum="EA8AECCDA15A8D1C" modified="2014-10-29" version="1">MQLQYIPATIDGDGPANLEKFFTPYTDTLPDGTLQNALRGYPLLGKRKTLPEGYTGVILQETKKPLSSDEDRTLTFGGAFREFTYWNYDRNPSRNDPFEKALNWLQLAEVLHNDGQDELQEKQESNTRVAEKSNQENNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFT4</accession>
    <name>A0A084VFT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003992</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012460">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003992-RA">
        <property type="protein sequence ID" value="ASIC003992-PA"/>
        <property type="gene ID" value="ASIC003992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003992"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7774" checksum="3592D1FA6A3D048C" modified="2014-10-29" version="1">MMLMLTAHPAGEESRSVSTSQRIMSTFKVLMNECSSDVWELHFHPKAMRLLPSKPGAARTRTGQHCVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFW3</accession>
    <name>A0A084VFW3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ribonucleoside triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004020</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524800">
        <property type="protein sequence ID" value="KFB36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004020-RA">
        <property type="protein sequence ID" value="ASIC004020-PA"/>
        <property type="gene ID" value="ASIC004020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004020"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004020-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11693" checksum="EDC48010B081E5E5" modified="2014-10-29" version="1">MRCAMREESLRLEDVLVRCYFASRLLGLHTAKIDVTQKLNAIIVQLQENALWLLLRNVPKRNPKHATTNVANGSERPPMGNIGTSRTQTNRLMVMMAYAIGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFZ4</accession>
    <name>A0A084VFZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">30S ribosomal protein S6e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004056</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012584">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004056-RA">
        <property type="protein sequence ID" value="ASIC004056-PA"/>
        <property type="gene ID" value="ASIC004056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004056"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="15742" checksum="EB78715006A27790" modified="2014-10-29" version="1">MHFKTSTTRFRSLRDTLWANPLITTARDDGPDQNDAIGSWSARGKLVGRLMMAKYTVEPTCKIMIATGRLQRDEFHCVRADLRSLDGLEPNDDHERTSRTLRQRRERDETKEAHAAIKHNNGSSPWAFAGASASGDRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG83</accession>
    <name>A0A084VG83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009116-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00004148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524808">
        <property type="protein sequence ID" value="KFB36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG83"/>
    <dbReference type="STRING" id="74873.A0A084VG83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004148-RA">
        <property type="protein sequence ID" value="ASIC004148-PA"/>
        <property type="gene ID" value="ASIC004148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004148"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006766"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004148-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="18046" checksum="C0ABD19509D9E5EF" modified="2014-10-29" version="1">MFPETLVFGLALLITGAILFLLIYFLIILSDLECDYLNAQQCCSKLNFWSIPKLAGHAFLVFLLLIHGNWILCLCNLPMVGWLLYEQYKVPPGNIGVYDPAEIHNRGMVKKHLRDTMIGLGFYLIIFFIYLYCMIIALLKGDPIRRHEEEEIITEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGS5</accession>
    <name>A0A084VGS5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">FBN9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004377</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013075">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524837">
        <property type="protein sequence ID" value="KFB37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGS5"/>
    <dbReference type="STRING" id="74873.A0A084VGS5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004377-RA">
        <property type="protein sequence ID" value="ASIC004377-PA"/>
        <property type="gene ID" value="ASIC004377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004377"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017940"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759835" evidence="1">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004377-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20065" checksum="6A1DB8B05E636CA9" modified="2014-10-29" version="1">MCSNVGVAIHCYRLVLLWTFFASAACTTGANSIENSIAGYGFEVMMAKLDYLQYKLHEIELGQKKRDEEFAEKFTKLEGSIENIQWAIIRHDRDAGHNLTTLQAHSRKILAQQTSLHPRGSLAYRCCTLSFDGFTGWKLLNPSTSSRQRMQRSVTENCSFVLICATPHVEIVWSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGV4</accession>
    <name>A0A084VGV4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004456</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGV4"/>
    <dbReference type="STRING" id="74873.A0A084VGV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004456-RA">
        <property type="protein sequence ID" value="ASIC004456-PA"/>
        <property type="gene ID" value="ASIC004456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004456"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021865"/>
    <dbReference type="OMA" id="CMEPISG"/>
    <dbReference type="OrthoDB" id="9886517at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF11">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="532" mass="60298" checksum="D8EE84E1A318644D" modified="2014-10-29" version="1">MLCWEGASDYDAPPTASRALPSQALHANTFTHSSRKSSVPLPWSTTTHATHNMEQISGPPAKTGTFYQTPRSHPWRPTMGYEAVEVTPLHEQPITNQLVASSYSPSAMCSDPVTFPNLVTGFERNPQHAARSALYTRFTPNEWTTSNVSTYADADKNRNYSEKVRSEAVRLMRETDEKTSQGQRDAARRLGERITDITFWRNELTTELEKLIAESAQLTDTKRNVQKALQDLEPPLHIAQECLYHRESRKGIELVHDHVEKSLLVEVDNLRASQEKLSQLLAKITKQLADCRAAQHSLEDDISHKESALGIDSICHQLNNYSRGINYYGGIEKYDPTVSTPGTWSGSSSTRINNSHSERSKSCQLRSDAESLINAVATSVWDCWSNTNNAFNNRASEMLEAKSKMQLHLHKTQQEIFDVEKHIELLRKAINDKSNPMKVAQTRLEARAHRPGIEMCRDNAHLRLVEEVCTIQDSVATLHRKLQEAEAQHQQLLRTKSQLESNLKQKVDALFIDREKCMGLRRSFPVNNTIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGY7</accession>
    <name>A0A084VGY7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004446</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGY7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004446-RA">
        <property type="protein sequence ID" value="ASIC004446-PA"/>
        <property type="gene ID" value="ASIC004446"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004446"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004446-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="8076" checksum="E60E2D10DEFC2057" modified="2014-10-29" version="1">MKFFDIYGPKSPARWVSDSWLINSSGLVCAWHHHTIINIILLDVSAQSKVSFIHPFPMVSGIARRRRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH67</accession>
    <name>A0A084VH67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004679-RA">
        <property type="protein sequence ID" value="ASIC004679-PA"/>
        <property type="gene ID" value="ASIC004679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004679"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013251"/>
    <dbReference type="OMA" id="LPACNAN"/>
    <dbReference type="OrthoDB" id="8067861at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004679-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="643" mass="70037" checksum="B1439F04989E4968" modified="2014-10-29" version="1">MSAGSNKLDKKLTASTATLSDKDPRDISNNGFNRFDPKYVSIGPKAIRNTVNNVTANVNKCATLRHGGRYGGSLSLSATAGGGGGAGGGHHGAPGARSGTSPSPNLKNVQQPILSQSQTQQYKQHHQDRQLAASGGGGGAGGGGGERSEPKLAISTVSKEYSQQSSTSYSCATLPYKKPGSGYTETSTAPTTVTTSILKKESNLDNQHQQRYAPTVYSIDTSSYHHQREGSGASYHHSAQSAQQQQQQQLQLQQQQTHHRSLSSTNQLYQETGAGSAFASPPPSIASTTTTRSNVSIINQPLPDIPTSAGGGGGGGGGSSIKNNQQPLCAATLNQYRSLQRPHKQQLQQQNSGGGLSVGTPTGLTGKPTIPPKVTPPMLPPKNRHKDDAQYQSRAAALASSSAGPPLPSSRPQQPLPQPPPPPPSAQSHHHHHSSQQQPGAVVAHGGASSGSRNRSYSGGSSSIDQPPHIPHSKPSNIEKAKSHHSSSSGGGPPPPSGSMQREREREQRERDRDRDRDRDRDHRDHHRERDRDRERDRDRERDRDRDRDRDRDRERDRDRDRERDRDHRDRDRDRDRDRDRDRDRDRSERSHHHRNSSSSHEYHHDSSHGNATANSKNPNVYYRSLQRGGLQANNDLYSVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHJ3</accession>
    <name>A0A084VHJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004571-RA">
        <property type="protein sequence ID" value="ASIC004571-PA"/>
        <property type="gene ID" value="ASIC004571"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004571"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004571-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="296" mass="33584" checksum="28FB7C6311E22096" modified="2014-10-29" version="1">MGLEVSRRHVLRRCLPKHYINLNPTNKRPDVYLRFTPSLGWKHQFQQWLTVPIKCHIAPRGGSIDPYIFTPIDAGGDRRISTGLAQDALERRKGTSSRLDGGREKQNPPFAKPPLHHRIDRCLLLALHGGGLWFFFLEHTIATRSGSNLFFYCFFVFASFHRPKGFDRASSSDRSSAARRVRIALADVGVMYFSRFAAGAFEPQRMQHARSRVLELETDTGRKLTKPKVGRSRLSGFGDRRRTVDYLTETTTRLGGGWQWQVTELNSYFQGKAPITECHEGSPVPLPGYSRAILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHR6</accession>
    <name>A0A084VHR6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004468-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00004745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524845">
        <property type="protein sequence ID" value="KFB37510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHR6"/>
    <dbReference type="STRING" id="74873.A0A084VHR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004745-RA">
        <property type="protein sequence ID" value="ASIC004745-PA"/>
        <property type="gene ID" value="ASIC004745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013213"/>
    <dbReference type="OMA" id="GIIEMMP"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="4">
        <location>
            <begin position="61"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="32080" checksum="CC9BD0AD3EA687CD" modified="2014-10-29" version="1">MATLDDKLLGEKIHNYCSSSEDEAGDDDCDSSEASKGGSSARVGSSKLSVASTEAPGAVQNKTHWTGTAGNTGPKGVIQDWQRFKQLEAERREHDEAEKLRLLKKLSITARTKEEDKAAEAMGELDAEFQELMDEDFLQEYQRKRMAEMLAMMDNRKGCFGELIDLKNGDDFLEAVDKEDKNVTVVIHIYREKYGPCTKMNVALQQLAKEYLNVKFCKFISSDAGLSNTFKTSGVPALLIYKGGQMIGNFVKLVDDLSDEFDFGDVESFLVENGIINDRSCKPAIVGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIR3</accession>
    <name>A0A084VIR3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000940-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005172</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIR3"/>
    <dbReference type="STRING" id="74873.A0A084VIR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005172-RA">
        <property type="protein sequence ID" value="ASIC005172-PA"/>
        <property type="gene ID" value="ASIC005172"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005172"/>
    <dbReference type="OrthoDB" id="5858677at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005172-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15371" checksum="442DA32C19CCA073" modified="2014-10-29" version="1">MIFMFSEVNISNTWTLPQEGFSVFYRYFRDKISWFEADAVCQFHHANLVTGKLTTVKEVATPVKKLAEADVSDVHEERTGSNAIERYPEESLWAAVAITQSWMSVQNMIPVRHRYESAHTDNQTNPDCSSNEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJF8</accession>
    <name>A0A084VJF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000990-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005377</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJF8"/>
    <dbReference type="STRING" id="74873.A0A084VJF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005377-RA">
        <property type="protein sequence ID" value="ASIC005377-PA"/>
        <property type="gene ID" value="ASIC005377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005377"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002903"/>
    <dbReference type="OMA" id="WRKRPCD"/>
    <dbReference type="OrthoDB" id="6619788at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="859"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005377-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129156" checksum="23D57CC249C2A16F" modified="2014-10-29" version="1">MANQKSNNVPDAKFDRSDGHRLTFECSEDEEVSMIFGFEENDARQKLNSFPKCSRLVISPDLQAELGMEIGSAVSVEHPWREIKKEVLEEHLPGKTKVQRQLKDRLRDLEPGRLVLMGYLADQSTEEENVFAVFTDQRETREARELIRRLELVERLWAAAAMRKKARRWQSHDSERDVENFIPKQRTNVVNVESQSIFPAQRAGSCRFRLRLVGDARDGYVALLPKGAFRNIVRKSIDFGVQLRPQKVHKFQQTDPTFPTNAWSQYLYEIGHEQRTASAATATATTQSGTGPAAPAQQDKQERAGAQASDHVVQLLDTLEFNQIDMYRNDYPIISRRKAIAKYETPHVGETMCFMERATCANRHVSAIEWHPTLAGSFVAAYVRHIPSVLAAGTESGRAEEDAVNRLVFEKCPVLAWNFDESLVPKLWFDSPREVTALSFCPYDERLLVGGLASGQLAIWELTNAQLEHAGPRAPERDTRAAGFQHHHPHQHHQSYRSEIKALLAGGTPEGPWHVRPVVISALERSARKPITVIRWLPPNYHCAPTGQLRVKGPEEKLGRVLLTGALDGSVCLWDLDQSVPVSQQDKDKGGTAGDGEGEPVGGAARERGEPGTQVTGMACLNNVLQPTFRVRCESPIVALAFDEPPPPGTGCRMAFVFGTLLGGLCWGKWDGYEFDQGATVNEEPVRELDPFAPVHDGPLVAIARNTFVPEVLLTAGGTVLALWTADCRQSPVFWRCKPAIVTACAWSLDRPSVFFVGLANGDFEIWDLQINTSTACVALNLGANVLSIITQQQQQQRGTVQRNLAVADGNCNVRLLSIPAAFGEPRPSERRRFRQLIRAELARKHEQQAWVQRYYEQNREQIEARLRAEQEARELAERLEVEKQEHDDFLRRQALEEAKKKALRDAEKRVDLSRRLECRWRSRYYRALIRTMMARRHLSPELLAKQMHPERERRRYDVRKRATIGESVAAAPDDYRRVQRALGLPGKAGSVHGDAHGGEDSAGGGQVRARLRETVRARFREELADYPRVSWEAKEVLRVFQLPLDLDNFASIVAKGRARRQLVLSDDHGNMEHLQAYLAKQAARGPGDRVNGLGPATGDDTESTVTNGSPDVPGTRATVGLQRARSVTFIDDVPDVGQKAATAVAGRGTEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJN6</accession>
    <name>A0A084VJN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005508</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013824">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524901">
        <property type="protein sequence ID" value="KFB38180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005508-RA">
        <property type="protein sequence ID" value="ASIC005508-PA"/>
        <property type="gene ID" value="ASIC005508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005508"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005508-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8020" checksum="D8DD3A3D9E48CC59" modified="2014-10-29" version="1">MDSGLWPSTVASAVTNHALMLLQIDWIPFPPSEFGFASHNGNDVRSMIIMSSTNRVRCDRRDRQCDVLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJP5</accession>
    <name>A0A084VJP5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00005500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01013833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524901">
        <property type="protein sequence ID" value="KFB38189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJP5"/>
    <dbReference type="STRING" id="74873.A0A084VJP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005500-RA">
        <property type="protein sequence ID" value="ASIC005500-PA"/>
        <property type="gene ID" value="ASIC005500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005500"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005808"/>
    <dbReference type="OMA" id="QAMMEPI"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="183"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005500-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="360" mass="41463" checksum="D7B33C92284041F1" modified="2014-10-29" version="1">MESVDPAGPASGALSPNTVNGNSGDLATNADEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNAMYHNKHLFKGKVVLDIGCGTGILSMFAAKAGAAKVIAIDCSNIIDYAQKIVEANHLQETITLVKGKVEEVSLPEGYDHVDIIISEWMGYCLFYESMLDTVIYARDKWLKKDTGMMFPDRCTLFVTAIEDRQYKDEKINWWDDVYGFNMSSIRKVAISEPLVDVVDPKQVVTTPYMIKEIDLYTVKKEDLEFESTFHLMVKRNDFVQALVTYFNVEFTKCHKRLAFSTAPDAAYTHWKQTVFYFDDYLTVKKGEEIYGTFKMKPNVRNNRDLDFTIDLNFKGELSQVDETNHYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKK9</accession>
    <name>A0A084VKK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009021-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKK9"/>
    <dbReference type="STRING" id="74873.A0A084VKK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005910-RA">
        <property type="protein sequence ID" value="ASIC005910-PA"/>
        <property type="gene ID" value="ASIC005910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005910"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009425"/>
    <dbReference type="OMA" id="TGRCVEQ"/>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="13696" checksum="D0579900595BA84F" modified="2014-10-29" version="1">MIIAGDYIEHTLGLFMCISTMAAAALGNTISDVIGIGSAFYVEKLAEMSGVKPPKLSPIQLEMKASRRAANLGRVLGITIGCLLGMCPLLFMKEDKEKEKSKDKAKDKDKKAPPTEDAANVAEKLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKR2</accession>
    <name>A0A084VKR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005834</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005834-RA">
        <property type="protein sequence ID" value="ASIC005834-PA"/>
        <property type="gene ID" value="ASIC005834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005834"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005834-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6469" checksum="805083CD2FCC8B1E" modified="2014-10-29" version="1">MFSFFAPLPAVIRYGHFTVVKGNHRPGFVGRGFRRSLSPEQEVASDTGGKKSNKSGTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLB3</accession>
    <name>A0A084VLB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP004140-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00006158</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLB3"/>
    <dbReference type="STRING" id="74873.A0A084VLB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006158-RA">
        <property type="protein sequence ID" value="ASIC006158-PA"/>
        <property type="gene ID" value="ASIC006158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006158"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002543"/>
    <dbReference type="OMA" id="IDRTPCC"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="416"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006158-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135093" checksum="A04E237EBFE90155" modified="2014-10-29" version="1">MHWYYKLLARRPHLVLVAVGIFSIACIVVALSTRKLPDFDDPTLGFEARGTSIGKRWTAWRNLLEETGASGRLVANPKELTYGNSNLRHKTGPASGAHVPKRRKPKSKKKVPAQTEGGQKKHTKLGKNIRILKELYDNRTVEAVATNGGEVISFEEYDNETAVQRGGGGRQEVWEYGRNQSFYTEEIGNKTMEKKRAKWDTLRKLRPPPEPIEIHIPSDGFFCESPNKEYAHLVVQRKNENYNDTLFELNAFLALCELEQKVVTVDHYGDICQRELTSDSCCRPWSIVNYVTFLSNKSSCFELNEEDVAMVKTLLFDCFQYYHNMKLSNDCMRSSCIAPSECKQHNAVYNILHYLANVDFIRQNESAEFLNATMIFLPVARSTKSMEFYHSLSQANLANDLVEVVAMDMGLKNALFDECLLRDGWLIGLGGVFVVLCMWLYTGSLFVTLMTVVAVAFSLGIAYFIYSFIFELTFFPFMNLLAVIVVVGIGADDAFIFLKIWQCTIVDRMKCGGGIVIPIAPSTSAACHAEVTGRGGNSDTLVEIMGSTLRHAALSMLVTSLTTAAAFYASYVSSITAVRCFGIFSGTAVMANYFLMVTWLPAAVSIAERMSCLMLLKPFARVSHRFSVPFIALAQFSRRLEDAIIGLVIGVPWLWISLLGTVGIFSGVLVLHWPKLRLPDSPDFKLFISNHPFERYDSEYKEMFWFEKMYTTTESFKIPLRFVWGVLPVDRGNFLDPEQRGDLFFDESFNMSAPESQRWLLQFCRRIKNQTFYQTSYGLLLPNCFIENFISWMARRCNDSMGEIDRTPCCEVSPFPFAPDIFDQCLPESISSLYETPREFFIPGVAGPKFARSSFVVDGENDREAEDAGKVVKAVVIEYESTQVFTMSYTEIDTFVRSVEGWLAEQLHDAPPTMANAWFISELEFFDLQDTLSTGTMVAIAMAMAVALLVLMLVTLNVLISLYAIVTVTFTILTTVAVLVLLGWKLNVLESVAVSTAIGLAVDFSLHYGVHYRLSTDGSDRRSSTRFSLQRMLGPTAMAAITTGIAGALMLPSSVLAYIQIGVFLVIVMSISWLYATFFLMSLLRLIGPQYGFGQFRYPKLRTAFRASADACKSSAQLDPDGAVSEQLLSNSSSAAGDLVGSESHELDSLTSNSIIKPVNLDIARPINFDRAFKKQQSLPREQSPSTASAITVVLPDDIDIRIAPIGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLS6</accession>
    <name>A0A084VLS6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006241</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006241-RA">
        <property type="protein sequence ID" value="ASIC006241-PA"/>
        <property type="gene ID" value="ASIC006241"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006241"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006241-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6929" checksum="2158A9938FACD17A" modified="2014-10-29" version="1">MQKPHDRKTDNKKWRGTDKVPETGSKSERLKTAKHKKNWKHSTQYGEREAPAVEREGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMC8</accession>
    <name>A0A084VMC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009083-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMC8"/>
    <dbReference type="STRING" id="74873.A0A084VMC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006451-RA">
        <property type="protein sequence ID" value="ASIC006451-PA"/>
        <property type="gene ID" value="ASIC006451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006451"/>
    <dbReference type="OrthoDB" id="6361509at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042344">
        <property type="entry name" value="ZCCHC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195:SF16">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-binding protein vts1-like alpha-helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="SMAUG/ZCCHC2-like PHAT" evidence="2">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="275" mass="30535" checksum="E7E3BC30F837ABE9" modified="2014-10-29" version="1">MCLPFELRFLGTYLEELGRRDAPELRGAELKVNNPQEFIADIASGEPTDHRSRRKMALFLALYRACNHTCATELFKTLEGWGGRPDLQRLFEEDVQHELLLVYTMATNHPAFSFEQRLHCGEIFSKLKSWEPKANPKQSDRDEMMLPTQVPPPSVAPLHTLTPNAAGIPIQLIPQGPSTMGQGTLTLSYTGQPITQTIGNDGTITAYHLDPMLPLHTDFTIPPPGPPAASVQSRWVQNVYQQVIIIPTTFIVTAYEQSIVADPESNGQSDANSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN36</accession>
    <name>A0A084VN36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006806</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006806-RA">
        <property type="protein sequence ID" value="ASIC006806-PA"/>
        <property type="gene ID" value="ASIC006806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006806"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006806-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7223" checksum="B9AB9F31DCDCB8FD" modified="2014-10-29" version="1">MSIGVCTSIPPPAPGSSTVSAPRCCSTLCSLKDQSRKTNCKLRSTLASEAAAFAVPAHLRLGLSGLYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNF6</accession>
    <name>A0A084VNF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006997</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006997-RA">
        <property type="protein sequence ID" value="ASIC006997-PA"/>
        <property type="gene ID" value="ASIC006997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006997"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001877"/>
    <dbReference type="OMA" id="PRNCINT"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000118">
        <property type="entry name" value="Abrupt, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF98">
        <property type="entry name" value="PRE-LOLA-G, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783682" evidence="7">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006997-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="444" mass="49459" checksum="8213FCF4E6D8716A" modified="2014-10-29" version="1">MLMAGILLADAFLHAGPAFFALEAVKQVPSVAAEKGHEFMIGTLVKLIPSKVYPAALCRFLNETDNEEEEEEKWLRHWNDFQSSILSSFRHLRDEEDFVDVTIACDSRSFTAHKVVLSACSPYFRKLLKANPCEHPIVILRDVRSEDIENLLRFMYNGEVHIGQDQLSDFLKTAQLLQVRGLADVTTGNPTGGRTSANSSMLNSSLSTPAVQELKASPTSTSLPWELPEDNNTAPPPQKRTKSSELYRKQHGLSPDDPIPLDLLPIGQHPLTRERDRSKDKSKDHHHHHRSTSSEHDLHHHHHHRERDRSLELRESLLGQALEGGPTLTVPSKHPDLISLQAAASGDDSNSSDNGASDHGEDDELNGNLEHTRPSFPFLGLQGIPGLIPGPSGIGDNFGEYPFPYFPCTFCAPRFGTLLFHRRLGFSRSHRVPRNCINTSTTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNH6</accession>
    <name>A0A084VNH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009628-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006862</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNH6"/>
    <dbReference type="STRING" id="74873.A0A084VNH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006862-RA">
        <property type="protein sequence ID" value="ASIC006862-PA"/>
        <property type="gene ID" value="ASIC006862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006862"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016708"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020875"/>
    <dbReference type="OMA" id="SFLCDNQ"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1235"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1245" mass="134649" checksum="259DAFC18029E136" modified="2014-10-29" version="1">MTAYIKHNIIAMGYPADRMESVYRNNREEVIKFLNEKHPENYKVYNLCKEKTYDATPFPVSFESFKHFSRLPFIKSKPTIENNLMTHYNEYPFEDHNPPDIELINKFCEDVHRFLCEDPKHVVAIHCKAGKGRTGTMICCYLLYSKACQTADQALKFYAEKRTWDHKGVTIPSQRRYVQYYEQLLRKQLTYENVTLYICELRIIPADVPLKFGTIKVKGSKESPPLTDFQRSDECVTVVLDACMPLTGDVKVEFARVRNLKEKRWHFWINTFFVKQTGNYDSQGRLVLTLDRMEIDDAHKGNTKKCPEQVCRFFKLFPTTTRLGLCWFPGVFVLIISLFISRCKCFSNRYLPAPFDVASSASNSPSSKVNYKKQQPKPPPTQLQSTATTVATAHQQLNHSGGSSEEISGTDSVEEDDYEEADEKEEDDEEEEEEEEEGWESGECQTVVSQTMCKSRTTTTTTTTTTTVNSSTTTTTTATTTTSSRTPEAAITAAAVSSTTATTTMSPTTTTTKQSSILPFSSPRRCLVSDENYLLTRSSSYLISNSNSSKSSSDHQHPVAGRDNSTPNHHHHQHHKPASSELVPVEYCTVSSSSSPAYILAGAGELPARAPGATKAGDSSLALMVYEPRGLVPVVPEQRVPPTSPSPSKGGSGGFPFPLVRRSPKGSGVAPIGTAVGSSSSSGGGIIEDRAPNSSVVPRGDDAGGKSKFISSSPFRRFGMAMQRKKKRSLKLKHSVTTGNASTTAVSGAAALYGSCASNLSGVSVGSGSKASGGSIISSGKSKMKFRWLRNMRSDPNLKETLAKSVQLRSVTATGGFASAFDQTGGPGKASGGGGVMIPKSPTVDKTCFVGIFEDEGRAERTAAAEGKVGTTRDNDYYSFLCDNQLSYESPSKSPGHLMRLELPRATRRPSTIEEVLLQQPLTTATTTVVSGGCETEGGCSVVKPRASNVRIGFDVSPVPQSPVAEKVSHQVGSDDADNLTSIESSFEIIDKCDAMTVSTAIKENPSAVGGGGNRFCNKLLHHIVSSVGSGGRKGELVAAPGNELGTSILEHRQHNSKADVDEAASTKIILDRRPSSSAATSTSLPGTPTKPPAPATDPRSCSPILARSNRCAPFSFRELSQELRAAMKIPKRAPFSQTASSATTTPGPSSSSSSSSFSNVGGGGDCTIAGRSIERTLSAPVAVQSLDTTTTTRPNTSATTTATTTTATTTDHNTRTIHQPFHRTLNRSQSDRQLLGEDRSKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP23</accession>
    <name>A0A084VP23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007408-RA">
        <property type="protein sequence ID" value="ASIC007408-PA"/>
        <property type="gene ID" value="ASIC007408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007408"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759867" evidence="1">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15510" checksum="5D657CDA920498A1" modified="2014-10-29" version="1">MARACRAPKNLVLVILAHLHTLQLVLIDEGANGVAQLVPRSPRNSASYTLICAWFFHLQCDKNSIAVALFRLTPFTFGSSSYATYGSIPCERDYAIKHFDSIPAALVLGNSRPGKEEKHALDLSSRHLGPRFITCRARMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPU2</accession>
    <name>A0A084VPU2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007374</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC007374-PA"/>
        <property type="gene ID" value="ASIC007374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007374"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="150" mass="17758" checksum="B1006522872AE66F" modified="2014-10-29" version="1">MMPRRSFRCIFKRFLQQPHHHHHHIIMVMSSISASTAHQLYHLHMERQNFASLKSIRPRAKRHDSMMRHDARRRPTRAEAEEKKIVLGRAPNHHQPKVEPNTISGWTGTAGENGWWKAGKRSITNKQRFGRGREREFMQLIFHIVIITFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ81</accession>
    <name>A0A084VQ81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007659</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007659-RA">
        <property type="protein sequence ID" value="ASIC007659-PA"/>
        <property type="gene ID" value="ASIC007659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007659"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="19050" checksum="544C44D36BBE1FD7" modified="2014-10-29" version="1">MSPSLLRRNYQRVVRPTILTRHFAELMSGKRAIAEFVESARRLLCVRRKQTGALINPSPHRYAQGAGQCDVRCAWGSAAHSLQYVTRVTSHAGSGVTYSPCYSGSPAGAEIALESPRTSTTPARLLSRGPQSNPNRDSRLHSTPHQSARLAHRLWEGASHDPGPELSNSSPGKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSU3</accession>
    <name>A0A084VSU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009982-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSU3"/>
    <dbReference type="STRING" id="74873.A0A084VSU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008656-RA">
        <property type="protein sequence ID" value="ASIC008656-PA"/>
        <property type="gene ID" value="ASIC008656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008656"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023035"/>
    <dbReference type="OMA" id="AQDVNDF"/>
    <dbReference type="OrthoDB" id="7743478at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784056" evidence="2">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="359" mass="40073" checksum="888809525AF2297D" modified="2014-10-29" version="1">MRCTVVVLVSWVALLMAGVRSAPQRGIDFLPGDEEVQAIVKPIAGDSDIPDQQQQQAPEQDEPIDEGQQRYQPEVPASVDPVENGQQKEDPAEEEIAFLENEENQEEPQTDPLETEEEINEPESDYPEDAEPNTTTETDATTQTESDVTTPPPTDANPSKEESASNASTVNYSPEERLTTVPIVVEEPTSTETNEEENQFAQEVNTLADNSSNQVRFEPEDNQYQPELQVRLTPEPKPTVPSQNVPKHSTVGSPVTSLPVSNEYDSKSIESDEEEYQVQLKVRPNAVQSTKEDQFRTLPPWFSSTRLPGNAREGDISPGSDQWQRPSSGPPRSSWPQPHYQTNSFDGFHGHTFHRSAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSW1</accession>
    <name>A0A084VSW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008814-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016144">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSW1"/>
    <dbReference type="STRING" id="74873.A0A084VSW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008677-RA">
        <property type="protein sequence ID" value="ASIC008677-PA"/>
        <property type="gene ID" value="ASIC008677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008677"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022598"/>
    <dbReference type="OMA" id="MHCPVST"/>
    <dbReference type="OrthoDB" id="10034090at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11467">
        <property type="entry name" value="bHLH_E-protein_Da_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000001">
        <property type="entry name" value="Putative transcription factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="479"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
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        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="589" mass="61828" checksum="1A0E5538D61874F2" modified="2014-10-29" version="1">MSHGYAPEEYTHESPVSGGQRYTSPKAGGALYQPEPYYDSPGGSWYPASSSGAYAPHSGTGYHNVGHGAGHLGGGGGGPQHNHDQYAMSPVGVPHMDGSHLTQNQTQALPPMSTFRGNSAQIPAIGTQGQNSPAIYNAIAAAGHHNQHAQHSPIVQNDTMVGKALQTMYPTDQSISSYGSNPNTPVNSPPPLTSQQQQQVQQQQQQQQSQTSQQSIHSGSAVGAPGGGSGANVAPGGPTSVSGVPSVASAAAVVAAAAGGSWPQINPVIGSNGGPAGLSSLPNGSYAPELVHRGLPHMANSPEIQQIEETLMVSLLREHDNISSLQGSRMEERLGDALDVLRNHCEPQVGVSLSSIDPAATASPYSTGGGGGGGGAGPIIPPSSQLQHDAPSELSAAPVKTERLPNSAAVNVNNIYHLSAEKRKEPPDSDTKPSSSVQGPAKGAKRQRKYKTSRSCSSADDDDDDDDLDPLAKDRKERERRQANNARERIRIRDINEALKELGRMCMSHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLPPHILHQSGYPALPGAPPTLPHSGPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT25</accession>
    <name>A0A084VT25_ANOSI</name>
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        <submittedName>
            <fullName evidence="3 4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008578</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008578-RA">
        <property type="protein sequence ID" value="ASIC008578-PA"/>
        <property type="gene ID" value="ASIC008578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008578"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759892" evidence="2">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19967" checksum="570874461473108A" modified="2014-10-29" version="1">MTSSRGGLHILLMILRRGLCAFSAYELRPQQICRPFGAGIRAFRRHPDQFPDTNGSGQPVLATNIGPIHWRAVFTLTFAPFPAGRTGPKKSTDASPKAERRLESVRQWPEPNSRGNLSIRTSFYSFHGETLDTRTEGVDRKMSCDDSGPKVFYVLPTEAHKFTACHKPVVFVQFHHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT84</accession>
    <name>A0A084VT84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008740</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008740-RA">
        <property type="protein sequence ID" value="ASIC008740-PA"/>
        <property type="gene ID" value="ASIC008740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008740"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="12999" checksum="D681FA12AE3EFE44" modified="2014-10-29" version="1">MALVVQQERDIGGRDRSTLAVERCRPRGQGLTTWDGLAPVGVEGVPGGPRLDGRMMAMGSDGEGSSPMALNYLITGAERSFVFVVRSFTVANWEALHTGGGKSRRYNNSELMEIRGWIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU64</accession>
    <name>A0A084VU64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP002444-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009101</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525099">
        <property type="protein sequence ID" value="KFB41508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU64"/>
    <dbReference type="STRING" id="74873.A0A084VU64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009101-RA">
        <property type="protein sequence ID" value="ASIC009101-PA"/>
        <property type="gene ID" value="ASIC009101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004532"/>
    <dbReference type="OMA" id="DWKTQTP"/>
    <dbReference type="OrthoDB" id="2101615at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000320">
        <property type="entry name" value="Pteropsin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB41508.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="429" mass="47861" checksum="527633D1348FFAA7" modified="2014-10-29" version="1">MNESPTDVASSVVDYEELMAAWAYNASAITLFFIGFFGFFLNLFVIVLMCKDMQLWTPMNIILFNLVCSDFSVSIIGNPLTLSSAIYHRWIFGRTLCVAYGFFMSLLGITSITTLTVLSYERYCLISRPFSSRNLTRRGAFLSVFFIWGYSFALTSPPLFGWGAYVQEAANISCSVNWESQTKNATTYIIFLFVFGLVVPLIVIVYSYTNIIVNMRENSARVGRINRAEQRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALIAKSSICYNPVIYVGMNTQFRAAFTRVRNKGAGPGADQNTTTMQREVTKSSRDMVECSFDFCRKKSRLKISLLKPPGQRTLAEASSCSHPGKDLSRSPPDQTVLNVTHDDTTRADRGSTVCPGTRFVRPEFELSVINSGKSILIKSKQFRSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUK9</accession>
    <name>A0A084VUK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009284</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525136">
        <property type="protein sequence ID" value="KFB41653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009284-RA">
        <property type="protein sequence ID" value="ASIC009284-PA"/>
        <property type="gene ID" value="ASIC009284"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009284"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023127"/>
    <dbReference type="OrthoDB" id="202764at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009284-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="201" mass="21242" checksum="5B1F7FBB59BFC44F" modified="2014-10-29" version="1">MASPFSNLRLPPTFPPGVGMPEPCGEMPPGMEDQSLHQLPRRNSELPPAKRLSPLKLSIPTPRASFSSSSSSEGPRQAATAPVFGGQMPNFAPASSTSPRMDDFHQATFSDFDSLESPMLQLSPEHSPIMAQLMTEVTSPGTASSQGSSSNGSSISRLMRFSPALHHHAGNIMTSFPSEVGDRSISSSSLAAEAASDFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUQ2</accession>
    <name>A0A084VUQ2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009326</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016983">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC009326-RA">
        <property type="protein sequence ID" value="ASIC009326-PA"/>
        <property type="gene ID" value="ASIC009326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009326"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007904"/>
    <dbReference type="OMA" id="SQAFHPL"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="523"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="762"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1410" mass="161245" checksum="D54EEE1D3A751D0B" modified="2014-10-29" version="1">MKHHRSSSVDIVVDSDSDNPRIPPRDRVDSYSQIEAKKDNIPPGKLLPPLIEGWSSLHQTDSTSLRMATGSPRKGCKDLEQLPGLEEFTTNGSFDVLLPNCVVQREQRDGTPGAKAEPRVRVSRTIHSSPVGKPRCRRYSQDSGASIYQQSVGTGTGVKFLGNSRKPKRVVEIGTVILISVFRTFEPHVAFLFPCSCNGVQGTSDDERSRIVPERDLKNLIPVPTHVLIPIICISPVQQTTQREYQASMRHSTDNLRSINNQSRGGGLCNGHQAQEMAPVGLDLGARNEDANHGNRKHLIQRMTAQDSVNSLEPATSQDSTASPSSLDPQAPATVEIVVESHPTVPSDGGSTLVNGSLPSVSPTDRSYIDKLPSLEDIMESPLLKTPMETPDPYSNLFGPKISVNEHIPGTPMDTPDIVSEFNKSFNSSTTSIINERRHSSSKLLGLQADSKEPTAMTSDTQGSPHDDLPPAGVALATGEKPLSLGKGSLRNLLKLRKASDHSQDTRRSSQQDKEGLDPESLMFRDGRRKIDMILCYEEEEQGVMTELEALKRHQRKLFHENLVREGLEIEVEDKMQAFDGKTYFVKIHIPWRTESRYAEVMNLKLPVKRFITISVKVIFGRRTALRRQQNKILGYWNRLMSLTEYNHERIEKEPSFYSATANGNPEEQFIVKDRCTSYTSAQRSLIVMQILMRTRFDETEKVNNVGIRRLLNDGTYLACFPLHEGRYDKDHSSGALFDRRLLYLEWARPIKWYKKQPLCLVRKYFGDKIALYFCWLGFYTKMLYAPAIVGLFCFLYGLASMDSSDNIPTKEICDEKGPGKTILCPLCDRACSYQQLHESCFFAQLTYLFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDLQNIENEEDMRPEFETTVKTFRINPVTREKEPYMPTWTRAIRFFATSSAVLFMISIVMGAVLGTIIYRISLVSVIYSGGGSFFRTHAKLFTTMTAALINLIIIMLLTRIYHKLALYLTNMENPRTQTEYEDSYTVKIFVFEFMNFYSSLIYIAFFKGRFYDYPGDDVARKSEFLRLKGDICDPAGCLSELCIQLAIIMVGKQCWNNFMEYFFPAFYNWWRRRKHKQLTKDETHLHMAWEQDYHLQDPGRLALFDEYLEMIVQYGFVTLFVAAFPLAPLFALLNNIAEIRLDAYKMVTQSRRPLAERVEDIGAWYGILKIITYTAVVSNAFVIAYTSDFIPRMVYKYVYSPQFSLHGYIEHSLSTFNTSDYKEEWGTKTESDPDTCQYRGYRNGPDADEQYGLSPHYWHVFAARLAFVVIFEHIVFVLTGIMQFIIPDIPIEVKTQMQREQLLAKEAKYQHGLKKSHETDYEEILHTLREQSNNSRQGMRGSWARRLSRLSDGLDAHVEVPNRPRHSLESTVWEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUT4</accession>
    <name>A0A084VUT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525142">
        <property type="protein sequence ID" value="KFB41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009360-RA">
        <property type="protein sequence ID" value="ASIC009360-PA"/>
        <property type="gene ID" value="ASIC009360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009360"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="6153" checksum="9A6F67C11D7ECA46" modified="2014-10-29" version="1">MEVSVERGKQRTSTAAATASTGAHQQQHRRLRKKRNGQRCRLRRRRRRGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUW2</accession>
    <name>A0A084VUW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009389</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525143">
        <property type="protein sequence ID" value="KFB41756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009389-RA">
        <property type="protein sequence ID" value="ASIC009389-PA"/>
        <property type="gene ID" value="ASIC009389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009389"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="147" mass="16513" checksum="2AAFEDFED6E1247B" modified="2014-10-29" version="1">MNQFLQTYRATPNRPCESSTVAMNMVKSIHDPPQTASSSTVTSKCTAEDIVPPEDTSTEHLKQLDSATQLKDGSPKAVKQSGYGDEFKTTSICLEESSSIVTANHHRVIECSSMVNYTPESTTRWKKKDTAFIKPRKRQRKTKCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV64</accession>
    <name>A0A084VV64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP010485-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009702</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV64"/>
    <dbReference type="STRING" id="74873.A0A084VV64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009702-RA">
        <property type="protein sequence ID" value="ASIC009702-PA"/>
        <property type="gene ID" value="ASIC009702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009702"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002701"/>
    <dbReference type="OMA" id="FPHFSGP"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF29">
        <property type="entry name" value="DOPAMINE BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB41858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="608" mass="69385" checksum="0ED33A22A96754B8" modified="2014-10-29" version="1">MKHKNNADAARHISTTQLHTLALDRGQLKLTWMMDWYKQDVLFHVKNPFAHGRYRTFAIGFSGRGQLSRTDLCVFSFSHGLYQQVHDSYTSRNFSRLFVDTLQHCEVMRVDENSVAFRRKFDTCDPQDIPFHAGTMYVVWWRSAEVLDLSRNWTVLPNVDERNHGVHPVQLLRADTIRVPEHPSELKQLDVRLQHVAVPAEETTYWCKIQRLEPWLTEAKHHIVQFEPLVDAHGAGLVHHMEVFQCTTDEHVDIPVYDGNCSDMPAVGRLCSKVMALWAMGAGTFTYPPQAGLPIGGPNFNPYIRLEVHFNNPHLEAGRNDSSGMRLSLVSKLRRHDAAIMELGLEYTDKMAIPPGQVAFPLSGYCIAECTGIALPPTGIEVFGSQLHTHLRGVRVLTRHFRGARELPNLNTDDFFSHHYQEIRQLRYKPRVLPGDALVTTCYYDTRGYVNATLGGFSISDEMCVNYIHYYPATELELCKSAISEKSLLNYFTYMREVENQTSVVPGGARSENYKSIHWTRTRADELLDVYLTEPISMQCNRSDGTRFEGFHWEDAPITPFKLPTGSRASAKSGKTCHPLTLSWFKPLVEGRCDRYGECIYADSKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVA4</accession>
    <name>A0A084VVA4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Core-E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009458</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVA4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009458-RA">
        <property type="protein sequence ID" value="ASIC009458-PA"/>
        <property type="gene ID" value="ASIC009458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009458"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009458-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10551" checksum="001D7E8BE6F10D09" modified="2014-10-29" version="1">MPHGGREVISRTRKDTTYRKWIIENPILTTRGALAPTATHTDGTLAGSESADVRLASGSISFQSQFEKLPPRAETPRDPFVLRFSGIQMRLGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVC9</accession>
    <name>A0A084VVC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009485</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009485-RA">
        <property type="protein sequence ID" value="ASIC009485-PA"/>
        <property type="gene ID" value="ASIC009485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009485"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12114" checksum="948A99886B68F092" modified="2014-10-29" version="1">MGYQQDLTLLEGLVRRAIGSTGGRHVTSWLIGSMAFHHGWQWTRTVHRAPNLRDLPEMQNIGPFTLQTGSWCFGLSIHIAPVREALLLGGNGMCDVFRDRCVGAYADSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW37</accession>
    <name>A0A084VW37_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAF3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009872</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525168">
        <property type="protein sequence ID" value="KFB42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW37"/>
    <dbReference type="STRING" id="74873.A0A084VW37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009872-RA">
        <property type="protein sequence ID" value="ASIC009872-PA"/>
        <property type="gene ID" value="ASIC009872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009872"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001689"/>
    <dbReference type="OMA" id="FRFLMDV"/>
    <dbReference type="OrthoDB" id="10258914at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.50:FF:000001">
        <property type="entry name" value="TRAF3-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="13">
        <location>
            <begin position="533"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="683" mass="74612" checksum="DAD084271DCBB977" modified="2014-10-29" version="1">MASELDPAVAKRTQSSLGKFVKRPALTEKLLRKPPFRFLHDIVHAIIREHGLLEGLYTADELNSDNIKDRDSKMAFLQKLIDVVKLITGQELKVRPSKVVAGLEPERTNELLQALGFVLEQKLSSTDAVRQYLANSSKVQPNGAVPAGPEPNATNGHAATNVSSESRKEKPKEKTKEKENAGAPVEKKKDRAAKSKEGGKNGAPNTVPVDGRAEKGKGKQNGTKSSPSTSTTESRKKGDKSSKGKEKEKPLKRIPSIPEEQQQTMGKGTSTNAPVNGSDAQVTNGKPTEGRKRKDSLKETVGESPPRSLVVEGQVADDETPLTADEDLDKRNKHSGSNSSSRRSSLKKQNSLTASENNALSEMNQFNGLERSPGPSRQDSGTAGDPGAHEGGEAPEHTGTTSITVTAAAEPKAPGKPPINRQQSVVIDTVMRPRTSLRPPSVRPPSARPGAPRRKEKNVEVILQPNETQKLGDINVKMEVFNNELLDDDGENLIVIEDPTASADVYGGVVIGTVDPSLMGDDGASPLASNEPEEQQGHLVQQILETQKEFSSHTGTEGEMLRKADMEWTTGQRQSSAKQMESLRDSIQKLTRSVNPLGKLMDFIQEDIDSMERELASWQQIYSQSIVELNKERSATESAIEPLKHQLSQIEVNIKEYRESIDSTRANILQNEQKIERLYMTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXF2</accession>
    <name>A0A084VXF2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycyl-tRNA synthetase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010384</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018050">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010384-RA">
        <property type="protein sequence ID" value="ASIC010384-PA"/>
        <property type="gene ID" value="ASIC010384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010384"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010384-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11588" checksum="1D9F6F6811C59842" modified="2014-10-29" version="1">MGQIPAKSARAAILFSKLVTITVKLILVYQCATASLSSTTQPQRRRVREITRPKVIDLWHACASAAEIVNHSRATPNCTVLSGPLGVWQTTCNNAPTMHFTAQKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY82</accession>
    <name>A0A084VY82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010794</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010794-RA">
        <property type="protein sequence ID" value="ASIC010794-PA"/>
        <property type="gene ID" value="ASIC010794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010794"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15595" checksum="9DD18E860EF9424A" modified="2014-10-29" version="1">MWKNLFDLSASHNRRRRWQQQVIIFSRLIRRKPTAPSVNAQEHGENKKQAKSARYRAGVAEIGATGTDVVRCGVCFRCLVRLVVVRSAGSDQRHFRIVTICRTRTSSGFLGRPDAQERGFVASEAVITYDQITNYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYJ9</accession>
    <name>A0A084VYJ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010718</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010718-RA">
        <property type="protein sequence ID" value="ASIC010718-PA"/>
        <property type="gene ID" value="ASIC010718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010718"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11994" checksum="0DDE2521E4D9D069" modified="2014-10-29" version="1">MATAVNCTNRSHRSPPGAFCSTTEEDDSLNEQVKSVPYDRMRWVEPKAGENHVFNCFGRPWNAESSQDVGTRMLVACKVSCRAAQPQDKERRKGPKYHIATGTVNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYK2</accession>
    <name>A0A084VYK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010721</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYK2"/>
    <dbReference type="STRING" id="74873.A0A084VYK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010721-RA">
        <property type="protein sequence ID" value="ASIC010721-PA"/>
        <property type="gene ID" value="ASIC010721"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010721"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012840"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010721-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="504" mass="55816" checksum="B36DDEA5EE825EA8" modified="2014-10-29" version="1">MEPEKRMLSKGPSSLVSWEERASTTAAAALNGVTPQRVRTDPSSPPSRSTTLSAITAEEKAENPHAATPVGMLGVWATQDIRPKPRPKSLTGADRRRHQIEIILKRRAILELKLQLIQLEEEEEEEEYLEGRPEELAEPLGCGTEAPHGEEAYASQPVVLFATTGCPPAGSGEDIPDAPRDDMAAFLEWRRAIDAKVRASAMAESINAPAMAHKLNNNATEKGHASGMAHSLDTLASHGNTATTSTLYIGFTAPTGHTAHTATHYGPTTQTIHASNIGHTALSTHTTPSSQTAATKHSSFLGNTSPRNGTDAYTFRPLSSVPHMKDEEKFDWATSARLREVTVSIQRRFRANRLMERQMEVYSRQKCAAVVIQRWFRGYRAMIEVRDRFIAIRQAAVALQQRFRAHAAIVLELLPDFCGAILSAPFRERRYNESSTNYKGPAPESIDRRQHERDAVRLQSWWHGGNHRKRFLALLLSELSGRTPMIAENSLKDALRSVSVLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYY3</accession>
    <name>A0A084VYY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP010676-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010979</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYY3"/>
    <dbReference type="STRING" id="74873.A0A084VYY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010979-RA">
        <property type="protein sequence ID" value="ASIC010979-PA"/>
        <property type="gene ID" value="ASIC010979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010979"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015556"/>
    <dbReference type="OMA" id="TMNHLRV"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07658">
        <property type="entry name" value="F-BAR_NOSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11823">
        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035656">
        <property type="entry name" value="Nostrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="530"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="955"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127430" checksum="2EAA406A2CA3A325" modified="2014-10-29" version="1">MIKRNYDVQHVAAAGGVGSKHGKSSSNLFDKLTKRYSGVIGTRFLRKTPGRKGGVAEPLSDSYDMCGTRSDDFRPEIGAPVLISKTMKFDFDTDSSVEQLPLPRVPSSRGVGRPAGTPSTSEDSENDVFLDANSSLPNFGEIRFTFLPESNNNCHSFRDGNVGGQGDAEGGRYRQLEKSRSKSAYNLHHHQQHHSTEVRLSLYSKAPSLNLSGNSDGPVFLHQTPRGTNATGTVSVPNSPAVESIYDFPRSTRSDGIRKPPGESTYDLTRSHHVLNEINLSLVSDACGDTLYQNLPSPVAHYDVPPVVQQSFASSTHSGGSAGSSTGSRSTREEEFDLKSASLQSLTDAGTGAGQLAVSMDELNELTRQINESAAFRGSAQQLPDSDEYCEHRKQLHPSERRLTLLKNRSAPGKHFIDFDRRKAKITKKWSGFKSWIGEEQGRIREVVQKHAAMQRVGDAAPNTNTSGGSSNAVRRHNSDLTTTTTTTSDADSRTENEATMPTPPESSVARRDRTLSSEDREGSRTINRKSVNAEILEGQNGFEEVRRFVKQGGDFGKDLVAILHERTEIEQLYAKSLSKIANKLNKACRDLPGTIAESWRSVSAELEGRSEVHRQFSNSLAEEVVKPLKAVIENQHKARKTIETNVDKSARILAEWRTAEMKAKKNSHGAARENEKLQDAMLDVKLQRTPSIGLLHKTNEKDTKVSEKDSSKLEGKRKKAEEAVKKADVEYYTLCIRAERARVDWEMSVLRGSSMLQTLESQRLAQFKTYVSDYLKLSAEMSPLLTKTIDRLSPQVAMCSVAKDLDVLKNIRRATEGPSEQLLPDFYCEHTTLAMNRERRKQSLVKLLQLIRQDLDRERRSRNGLKGFSQTLDKNGESNQNIADKLYHIRSMLTYLEGARYKLQSALLELDHKPRSSHPLAQHIQITRDRTGLQTSVLKVPLWLKHDQDDEGNLETSGGTNNGRDYSAQNCETDESGEQNCLDIKNDTLIKHIVHKYARSGCNGEQGHYTVTKVGKPTVQDESSPVWDRGVADGVSNQPDSDFDEFSSQDEDDDPKPAVKENGCHPATGSGPNADGTEIGCSGTAPSKQSIVLGHCRALFSYTPKLYDELELQPGDILEVHIKQEDGWWLGALRGQIGIFPATYVEEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZI9</accession>
    <name>A0A084VZI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011178</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011178-RA">
        <property type="protein sequence ID" value="ASIC011178-PA"/>
        <property type="gene ID" value="ASIC011178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11720" checksum="324FBC83F2646398" modified="2014-10-29" version="1">MFEKQFACAVDRSGRWRESEPYNPYRNTTAMRYKKTGRRKAQTVPERKKKNNNTEHVLGGALLPCGHRCSLTAPNLGYCQNDRPGSGFTVSINSPERVVCRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZK8</accession>
    <name>A0A084VZK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">EGF-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011199</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011199-RA">
        <property type="protein sequence ID" value="ASIC011199-PA"/>
        <property type="gene ID" value="ASIC011199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011199"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="12706" checksum="677BA14840C17493" modified="2014-10-29" version="1">MHYWMMIEKVYHPAVAFRPGTDSASGSERDSVRSKRLTGNQRFVGPSPSLSLRKAEKSKAVIKVDFIAGRTRADLASSSEKRISVCAEDRVGLDNVVCPSVPVPSEMNDMPSLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZV0</accession>
    <name>A0A084VZV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP004729-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00011299</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZV0"/>
    <dbReference type="STRING" id="74873.A0A084VZV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011299-RA">
        <property type="protein sequence ID" value="ASIC011299-PA"/>
        <property type="gene ID" value="ASIC011299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011299"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009221"/>
    <dbReference type="OMA" id="QCIHQVS"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="446" mass="50737" checksum="100845DE8F0B4486" modified="2014-10-29" version="1">MEQLTVKNIELDKICRICLVVKKEMRPLFGEMVAEMLMEIAKIQIEHMDGWPDKICVQCIHQVSRCHAFKTRVEKSDIALRQYIKGITVVAEPEPKEVIPVEMPKMSLSPPKLQQIAPALVPQQLHELHIQRTDVQAIQAEAPVAAPAMILTSAQLINAGAQIINAGHIITTATGQQIIQTTPQFQATSIGQFIQGPNNTVQMITQNGHPAHVLQIQRTADDRCEIIVQPEITEAQYLENVASMPVMVTAPNTALPADSLHMHPADHMMHHHAHLESHEPEQIELEDSEEEAHMEEEKLEEPDDNDCMIADDETVETDEMIEEDGGIDDTEIEYYAQTECEETDEEEKQIGADTTDFVTFQTSCPSPGRYVCNLCHKEFNQPKWLQMHMSSHANWIKKTFECSMCEKKFSSKYQLNMHEQRHRKQRSHKCPHCDKAFFHESELNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0I1</accession>
    <name>A0A084W0I1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP001161-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00011459</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0I1"/>
    <dbReference type="STRING" id="74873.A0A084W0I1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011459-RA">
        <property type="protein sequence ID" value="ASIC011459-PA"/>
        <property type="gene ID" value="ASIC011459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011459"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020216"/>
    <dbReference type="OMA" id="YFAIFRA"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001391">
        <property type="entry name" value="Opsin_lateye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00578">
        <property type="entry name" value="OPSINLTRLEYE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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        <property type="entry name" value="OPSIN"/>
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    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="165"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="214"/>
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            <begin position="276"/>
            <end position="294"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="66"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="350"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB43725.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011459-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="372" mass="41588" checksum="B2C81E7004B6A35B" modified="2014-10-29" version="1">MAAFAEPHFSAWTQTVVSNVTVVDKVPPEMLHMVDAHWYQFPPMNPLWHSILGFAIFVLGVISIIGNGCVIYIFTNTKTLRTPSNLLVVNLAFSDFLMMFTMAPPMVINCWYETWVFGPFACELYAMLGSLFGCASIWTMTMIAFDRYNVIVKGLSGKPMTNNGALLRILAIWAFALLWTLAPLFGWNRYVPEGNMTACGTDYLTQDFTSRSYILIYSGFVYYLPLFSIIYSYVYIIQAVSAHEKNMREQAKKMNVASLRSQEAQNTSTEMKLAKVALVTISLWFMAWTPYLVINYTGIFKAAPISPLATIWGSLFAKANAVYNPIVYGISHPKYRAALYQKFPSLSCQDSNDDGQSVASAATGVSEEKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1F5</accession>
    <name>A0A084W1F5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00011880</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ASIC011880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011880"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8324" checksum="377FB096A4130C32" modified="2014-10-29" version="1">MGLKYIDKRETIKRQFRSKLKPLIRNRRNVTCSAGRPAAAARYRSNEGQGHDSKCRHPDPPGKDKHDKSHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Y3</accession>
    <name>A0A084W1Y3_ANOSI</name>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="ASIC012120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012120"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13297" checksum="A8AC8095F7A3435F" modified="2014-10-29" version="1">MTPADDAVQLVNEMCANCASHAGSANARSSRRGFGLLFVLVRRSSAMGRLGPTLVVGRTTRHQESRKYAKAGRQPSAARCSRQNRCRLATEHRAGGNQQRTLDGSTVGWRPASYLLLRIVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2C2</accession>
    <name>A0A084W2C2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012307</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2C2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012307-RA">
        <property type="protein sequence ID" value="ASIC012307-PA"/>
        <property type="gene ID" value="ASIC012307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012307"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9399" checksum="C0B233249F3EA064" modified="2014-10-29" version="1">MTNNMNPNSHMVGWTGFHFEEETGYHLPAYTTINYQEFSNFHCLPTDFYSALNRDRLRDFVCERTESRLHQAPLTSSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3B3</accession>
    <name>A0A084W3B3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012599</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525284">
        <property type="protein sequence ID" value="KFB44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3B3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012599-RA">
        <property type="protein sequence ID" value="ASIC012599-PA"/>
        <property type="gene ID" value="ASIC012599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012599"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023657"/>
    <dbReference type="OMA" id="NCNGRYG"/>
    <dbReference type="OrthoDB" id="7735053at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784471" evidence="1">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="514" mass="55368" checksum="CE69B78E33CB9BD6" modified="2014-10-29" version="1">MVKWAAVSAILVSLLFGLSHASPDLGLDIEIDFVTRNSPNINAAASLVGEVSGNLQGAIGGYQIPRFNGVTSLIQSGDSLVKLVNVITGPVNDVLRNISVIARERQTAPSCMFATINATIDRAYAVLDTAPTLVTNIVSSTSTQNGNAITSAVATLLDALTQITTNLDALYKQVVAVLAAGTVTSSTVSANIQINTLIQLSGSIAVSTTMQRALTTTVQAVRTAFEQANNILTSYNNDLGNAFTSVNNTQRDYYNQIVSRVQSFQSKVTSDTSSGINEIFSTQSRLNEFIQDQSTRTQAQALRDAMISFNTSYRAVQDDYFQKLQTQITQVYTGTDGFVKSTVLQLTNIVNATNFRLAATMSFGGPYAGNCNGRYGGTITSLQNSMRDVLNRALNEYANTGYTDSFVSEYNQVMREQTRYINTRVNFCLNLGSTSSSAIIKAGIARCFTETVAMITTLLQDITFETKLVLAAVNLEGLAMIQRAESTASLVYHGLMAKSQSLDMLLAMCQTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3F9</accession>
    <name>A0A084W3F9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP001613-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012662</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525289">
        <property type="protein sequence ID" value="KFB44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3F9"/>
    <dbReference type="STRING" id="74873.A0A084W3F9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012662-RA">
        <property type="protein sequence ID" value="ASIC012662-PA"/>
        <property type="gene ID" value="ASIC012662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012662"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023424"/>
    <dbReference type="OMA" id="FRQYKGS"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02994">
        <property type="entry name" value="PDI_a_TMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784213" evidence="14">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="339" mass="38132" checksum="51C17AFBB2598C1D" modified="2014-10-29" version="1">MTLRPIAVALICGLAVHLAAAQGANSKSQVIELDESNWDRMLTDEWLVEFYAPWCPACKSLAPIWDDLSTWSDDLNIKTAKVDVTSSPGLSGRFFVTALPTIFHVINGEFRQYKGPRDMNSFMSFVEEKKWEALEQVSAWRKPDSIQMSLVSLFFKLSHFLKVSKTRLRELNTMLLKEYGLPVWGSYTLFGIGTVLLGAIFGLILVCIIDCLFPPKSAQRQSFSEHKQKVRAEKVPEELRGDELVDEDEEKRTQEQGDDDDEEGAESEEKETSEGEKYSGSDDSDDEQQEEPAAEEQLEGDKKTNEPAVASAVEPADDKKEKPTTTSPDVRKRKARKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4B1</accession>
    <name>A0A084W4B1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP005684-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4B1"/>
    <dbReference type="STRING" id="74873.A0A084W4B1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012881-RA">
        <property type="protein sequence ID" value="ASIC012881-PA"/>
        <property type="gene ID" value="ASIC012881"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012881"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012543"/>
    <dbReference type="OMA" id="HETCANT"/>
    <dbReference type="OrthoDB" id="10035606at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000111">
        <property type="entry name" value="GH06387p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF139">
        <property type="entry name" value="SYNTAXIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012881-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="367" mass="40193" checksum="2206858AA318A431" modified="2014-10-29" version="1">MVIQQLSKCKNVLTAFYASHFVTLNCVSVRTSHLSSSSHEITLHTNSSSSSSNNSSKMEPSEEDAKIPLKLAQISIDKFNQTVPQYLAVLRNHKCNIEKAGSLKNWEKVKREQINATRIVKQIKFMLVEIDKVRNRIRACDCDKFDAGIEGTKTSAFNSMAEYMAMQQTIRAQSAKDYEEQYGEEGSESASQFPTGGRLAFVPQITSSFNIEDHELQQREECFRQMEHLQREMEDIQEIYQKVHALVHEQGETVTRVEENVDVTQIQVEAGVTALQKALAYKKAVYPLAGAFLGTCIGGPIGLVVGLKAGGLAALGGGLVGFAGGKFIKNVDAIQEHDEVDSNDSATEATAGALVESGEAAPIVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5F8</accession>
    <name>A0A084W5F8_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5F8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013388-RA">
        <property type="protein sequence ID" value="ASIC013388-PA"/>
        <property type="gene ID" value="ASIC013388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013388"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013388-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9151" checksum="5F53BD7421F27462" modified="2014-10-29" version="1">MASRPGKINDGTQGTEPAAATLLDGQNGPGPLRSPGGRKVLSVCTFTSADSTQRTTIHRGERGHGSEWLRPSATECSVRVKGNHILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5R2</accession>
    <name>A0A084W5R2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008335-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00013590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020688">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5R2"/>
    <dbReference type="STRING" id="74873.A0A084W5R2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013590-RA">
        <property type="protein sequence ID" value="ASIC013590-PA"/>
        <property type="gene ID" value="ASIC013590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013590"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012252"/>
    <dbReference type="OMA" id="DDYWCRV"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
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            <begin position="131"/>
            <end position="561"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB45556.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="672" mass="75989" checksum="F5D4FA20E4FE0B78" modified="2014-10-29" version="1">MNGKKCDGSPKPKMKPTSEVVKEEEEDAEILESEKMVSEEPFDLDELLPVIGEFGRYQKLLLWLICLPACIPCGFCAFNQLFMTDVPEQYWCRVPELENFTADERKMYAIPMIENDGVESYSKCSRYAVDWKEILNYSDVDDGFAPNSSWPTEPCLDGWEYNKTVVQSSIVIDFNLVCDYDIYPTLGLVALNTGGPVGVYLFGLLNDRTGRRISYFSCLATLLLGSFITAASTSFWMWAFSRVIVGLTIPAVYQIPFIIALELVGPNYRSFVTVMTCTFYTFGIMMLAGVTYLIRDWVELTLYTSVPFLLYFLYLLVMPESPRWLLMKGKLEEALQILETMARVNGKQLPDSFRKRLQQRVLAEKSRTTKRTETSIGAFDLCKTPNMRLKTILITLNWFANETVYLGLSYYGPSLGENQYLSFFLSSLVEIPSYIICWIIMDRWGRRWPMCLLMILSGISCIVTVVLSEDAVTETLILYLLSKSMISASFLIIYPFAGELYPTQVRGVGIGTSSYIGGLGLIVIPFITYLGKDNLRLPLVIMGCVSVLGGFTGLRLPETLHHRLPQTLEEGELFGQDWTFDECFRCIPIKKSPVGSYENLSHDPSDTALELNAAVPINASTYATGSGSCSTERTPLEIARIRRQSMKRLVRQASTMDTQKTKDGAMQLTYWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5V2</accession>
    <name>A0A084W5V2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013585</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5V2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013585-RA">
        <property type="protein sequence ID" value="ASIC013585-PA"/>
        <property type="gene ID" value="ASIC013585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013585"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8934" checksum="BA430F61F0212F1D" modified="2014-10-29" version="1">MNHPGSSTCVPMKDAKVAEVARVCRTTTMKAQLIDILAAVCGHTVTLPASVEYRRLYSQEFVPEDTKLTDALDDCTEDDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W726</accession>
    <name>A0A084W726_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">BIR repeat-containing ubiquitin-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Baculoviral IAP repeat-containing protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Ubiquitin-conjugating BIR domain enzyme apollon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">ZHAS_00013990</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="32 34" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the BIRC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021094">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W726"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013990-RA">
        <property type="protein sequence ID" value="ASIC013990-PA"/>
        <property type="gene ID" value="ASIC013990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013990"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024510"/>
    <dbReference type="OMA" id="TTWDEHV"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000001">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12356">
        <property type="entry name" value="BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="23" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="29" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="22" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UBC core" evidence="31">
        <location>
            <begin position="4672"/>
            <end position="4839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="840"/>
            <end position="884"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1160"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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            <begin position="2428"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2936"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="3121"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="3583"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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            <begin position="3945"/>
            <end position="3995"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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            <begin position="4170"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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            <begin position="4345"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
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            <begin position="4909"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="5083"/>
            <end position="5184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="29">
        <location>
            <begin position="2159"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="30">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
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            <begin position="2450"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="30">
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            <begin position="3121"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="3584"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="3962"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="30">
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    <feature type="compositionally biased region" description="Low complexity" evidence="30">
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            <begin position="4924"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="30">
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    <feature type="compositionally biased region" description="Low complexity" evidence="30">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00060909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00069601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00075349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00081222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KFB46020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="5184" mass="562498" checksum="02D6AFB0227D9597" modified="2014-10-29" version="1">[encoded data, 5184 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7S7</accession>
    <name>A0A084W7S7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00014256</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7S7"/>
    <dbReference type="STRING" id="74873.A0A084W7S7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014256-RA">
        <property type="protein sequence ID" value="ASIC014256-PA"/>
        <property type="gene ID" value="ASIC014256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014256"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015877"/>
    <dbReference type="OMA" id="VEFWPLA"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF324">
        <property type="entry name" value="LD17001P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="84"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="413"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="700"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB46271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122609" checksum="3B8D0843F5BECAD1" modified="2014-10-29" version="1">MEGSKTSSEPDRTTPSHRSAQIGATFGRHWEREASAARNSPIDGPGKQGSGGTGGTEPQQNKLPAPWRLLRTVLRIYGTGVLTFGFFYSSIESACRIGQPFLLGQLILYFDQQRSGETSGSTAISLGEAYGFAVGIVATVFAPLAIFHSYQLFLLQVGMKIRIGCCALIYRKVLRLGNTTEGLSGTVINLMANDVSRFDYAVIFFHDLWKGPVELVIVAVLVYLEIGWAGLIGIGFLLLFIPIQAWLGKRSARYRLATALATDERVRFTNEILRGIQVIKMYVWERPFEQIVHRLRRKEIQALRGSAFIKSALFALRIVPKVSIFLTLVSYVYFDNALTARRVYMLISFFSVIHHSMVEFWPLAVTSAAEGWISLKRIQEFLMQNEISDVHKERAEEKIPPVSTNNAGFNPTVEFINVHSCFPDSNFSLQDISFSANVTTRRTLGIVGPIGAGKTSLLNLIIGEQRASQGKVVVDGTVSYCSQKPWLFEGTIRQNVLFIEPYEEKRYRQVLKVCALEQDVRMWPGGDETLVGERGISLSGGQKARISLARALYRRADIYLLDDPLSAVDAHVANVIFEEGIRSFLAGKLCILVTHQLKFLNNVEHIVMMEDGKIAAQGCYAELTNHFDGSLFQDYVQSVESSKSELCAQEDQLNKPSEENEPKEGQEDGTIQFKVVDWEETYANTTDARWTTDDHVLFYAGAIILTMFMTVNSFAFFEMCLKASLHIHSALYKGVTETTMYFFNVNASGRVMNRFSKDIGLIDSSLPIVMIDSLYFFLELFGIIAIVALANYWLLVPTAIMGCVFYLLRFVFLRTARNVKRVEAITRSPVITHTNATVEGLATIRAFGAERNQEDAFHRLQDRNTSAAFLFGATTRGFAFWLDVICLLYIASVVLSFLVIGNDIVSGNVGLAITQVLNLVGMCNWGIRQTAELENQMTSVERLLEYARLEPEPNFAPGSSKALAPGDAWPENPSITFREVYLRYSPTAAPVLKGLSFDIKPKERVGIVGRTGAGKSSIIQALFRLTPTTANGDQPDDRGGIIEIDRINIGSVPLRQCRSRISIIPQDPVIFSGSLRSNLDPYERLPDERLWKALEQVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8V2</accession>
    <name>A0A084W8V2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00014552</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01021515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8V2"/>
    <dbReference type="STRING" id="74873.A0A084W8V2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014552-RA">
        <property type="protein sequence ID" value="ASIC014552-PA"/>
        <property type="gene ID" value="ASIC014552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014552"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019892"/>
    <dbReference type="OMA" id="WCAEQKV"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8W7</accession>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ASIC014569"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014569-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9537" checksum="4C311FD3B39ABF98" modified="2014-10-29" version="1">MHRSISPAGPFALRSAVAQPPQDPQEAAAHQAARGSKVLMMLATAHDREDQIVRMKPFPGGGAENENVALRLSCAACYRHSGVHTGCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAA6</accession>
    <name>A0A084WAA6_ANOSI</name>
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        <submittedName>
            <fullName evidence="5">AGAP005953-PA-like protein</fullName>
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        <name evidence="5" type="ORF">ZHAS_00015080</name>
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    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB47150.1"/>
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        <property type="protein sequence ID" value="ASIC015080-PA"/>
        <property type="gene ID" value="ASIC015080"/>
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    <dbReference type="OMA" id="QNTHHDI"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DUF7819"/>
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        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="488"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="500"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="583"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="898" mass="96472" checksum="138507A8A4CEE274" modified="2014-10-29" version="1">MEIPPPAPNDIELRNIIDKLADFVARNGPEFESMTKSKQRGNPKFAFLYGGEYYNYYQYKVITKQATQVQHPSQLAPPSSNPNGSGSTNTMAQIWSNPPPVNAGPPNAAMPLGPNNLNSQLTAQLEALTKQQQTLSEQIRQSEMNLTAQHGVLLQQQQVQIDESLTRAQEEMLLAQAKENNISLHEFDTKLQPIIDSCTKDSISNGKGWILQHCTDSGKCQIISQYLLRKALIAGVLFTQKLHLIYLVNDVIHHCIRKNADELKKCLESAVIPMFCNAKITAANEEQRGKLSKLLSLWESKGNFFDACVISKLKSPPSSLQEYQTSLMTQHANVVAAIHQATKTTFENYQQQHQAFVQHATQQIALLEKQKQQQLEQHARKAGLSQLPPPLMPELMAAVVGANNGNAANGPPGVAAPAGGGGTGGQIPSLLDQNINFDLLSAALQKLKNITDNGPAPGGNGGPGGVVQGGANNIPPPQAPPQGRDADGGGGGGGGGDYTQPPPNFPIPDLSRPPPNFQYGAASNQQTDGLHNSNSNSSGDQHHQQHQHHPGLDGDHDERHDRPMGGSSGLLMHDDRDRDEFDQHHHHSSGHQSEHQPSEQALGEASDGDTPAAAPQPVKIPYFELPAGLMVPLIRLEDFNYHPLDPDEIRLPPPTPTNDRLMGAVEAFYAPPSHERPRDGEGWEKLALYEYFKVKNASRKQKEDELERGVRERSRSPXXXXXXXRSRSPSRRSPSSNAGGASMAGRRGRSRSPVRRGGSGAAGGGGAAGMDRDHHRDRGGREVRRSPTPPSFGGGGGGYMKASNFLDETSKPGGSGHPMHHVMKGGGIGGGGGAGGMGSIGAGGSGGGSMGGDRIGLGATIEPFRHEAHNPADPYESFRKNKGAAFITRMKARADERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBN3</accession>
    <name>A0A084WBN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015725-RA">
        <property type="protein sequence ID" value="ASIC015725-PA"/>
        <property type="gene ID" value="ASIC015725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015725"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="9551" checksum="F7A15195BC0C1182" modified="2014-10-29" version="1">MPGTRDLLAASAPNIKRSAPTPSDRASDHRVTSISYHFAEMRTRPSVTPALGASAFDPHPMDRSPMGPSGGGDVDNSLAGSWMLRMVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCC7</accession>
    <name>A0A084WCC7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF220 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCC7"/>
    <dbReference type="STRING" id="74873.A0A084WCC7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015925-RA">
        <property type="protein sequence ID" value="ASIC015925-PA"/>
        <property type="gene ID" value="ASIC015925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015925"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002628"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022615"/>
    <dbReference type="OMA" id="INCQSCP"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF220 middle" evidence="2">
        <location>
            <begin position="34"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="519" mass="57403" checksum="C7477136C3B95068" modified="2014-10-29" version="1">MIVPFSPSRTGTARREFKRCIGPPKKSFVGTPPPNACPICGVQLSPSDLETHFSAELTRLTKMTTHAERLELRRTLSVDLHTVQNNLQGRTSRWETFKNIRNKRQDRLRGKLRKRKFDGEDGFGLQLTNINCQSCPVCHGRLQRTQEEIAQHIEECVRKHHLHQQQQQQQQQTSQQTPVTPASQQSSPQDEDETVDVESYGDETSNGAINMSSNVIHHTSATATGNGLLHTPGHNNNNNIIKPDNSAPLTKLPPMEESAISSLSSIVPHWDRGKPRLNLPLNCKQGALMDEPRPWTTVVKPRLMTGPFESATQGSGAGGATAPTDHSITRVTPTSSDQRIDVDYDQEHDHSQDMITDNDEEVIVDNTDDEECMKPARPPRPTVQHLNGHPTMPSAMNGAPTPANDSKNSTEEATSSVEIDSATDSMSASRTAGTTPNSDSYVSTSESAEPSSKAQVLEELKARIRELEGSPHYKCFICKEKCKTLIISKICGHYLCEECWITESVRSSGELCHTLVQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDC0</accession>
    <name>A0A084WDC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016333-RA">
        <property type="protein sequence ID" value="ASIC016333-PA"/>
        <property type="gene ID" value="ASIC016333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016333"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020105"/>
    <dbReference type="OrthoDB" id="7743177at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="14230" checksum="457719ECB96BB5C2" modified="2014-10-29" version="1">MEQKFIIGFFVIIGAVLTAVPSVSSAVVVGKSLNAAHSTELQNTQPTTVSSGVLDQGPTRNKRAIIFRPLFVYRQQEIKKQKLKEMRQQQQQQQQQQVVHRISHQPSTRKPVRYYAQYYPYQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDC9</accession>
    <name>A0A084WDC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007588-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDC9"/>
    <dbReference type="STRING" id="74873.A0A084WDC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016343-RA">
        <property type="protein sequence ID" value="ASIC016343-PA"/>
        <property type="gene ID" value="ASIC016343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016343"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016694"/>
    <dbReference type="OMA" id="VFCNSHG"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="451" mass="50481" checksum="6AEF3CEA54175E8A" modified="2014-10-29" version="1">MVSPYKLSKPVANYREIVVKKVEPSNMTKDFLQKNTGNSFMGMVNLFQSQIRTAEMALEDPQLQAIKSEHFDLVIVGYFIVDFVLGLGPHFNAPTAILFPAGLSKMTADFVGNPRAISTVPHILIGGRGMKSFRDRLTNFLFSGVENVISAITSYAQASYYERFFPSDRYPTYGDVRKNVSLVLLNTHFSQAIPRPYLPNVVEVGGLQIKAKPDPLPKDIQEWLDGAEHGVVYFCLGSNLKSADLPQVKLDAILNTFAQLKQRVLWKWESESIPNAPPNVLSKSWLPQDDVLAHKNVILFISHGGLGGVTEAKYHGVPVLGIPIFADQSQNIQSMVADGIALQLDYQKLDEESFSRAINIMVSEHRFRDTIKEISRVYRDRPQTALDLACYWMEYVARHKGAPHLHYPGADMSFLELHSLDVIGRCRVEVRHLAVRRVTNEPAPPSASCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEJ5</accession>
    <name>A0A084WEJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006362-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEJ5"/>
    <dbReference type="STRING" id="74873.A0A084WEJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016631-RA">
        <property type="protein sequence ID" value="ASIC016631-PA"/>
        <property type="gene ID" value="ASIC016631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016631"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017021"/>
    <dbReference type="OMA" id="ATDGMDQ"/>
    <dbReference type="OrthoDB" id="8196075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784850" evidence="2">
        <location>
            <begin position="35"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="470" mass="50670" checksum="4CA5648F64A587DC" modified="2014-10-29" version="1">MPPPFGNGGSRTRKWVSKVTLFVMLCVTIERTEAISYRKDSGFATDGMDQFVFRESPGSSTGSSSGGSTVKRAGRVRFVDGPAGDSFQQGSSGVPTYNRGTVESVGGGGFFQGGSSSNRDRERDQFYTVGASIQLAGGSGDMITPPPPVESQPKPKRKKNKYKYSNANEKIYTPDDQGSFTPYAGFGGVAQRYPAPLQDNYLTPGGRPVGGQYENSISNYPELQKQQYPFSVNSPYPGVNNYYYGGQQQAVPGPVAPNNPYQYQYPAQYTPQYATQPYAQNNPGFYQQPQQSFGAAPGGQQPPNAQSILGVLQSIFNFAPGTFGSNSPAATPTRPGGLYSPAPTSPFVGGVGGQLRQALDNISENDELQCVPKLVCMMSRSSTGQGFSLVNRGLLSTILGAVPDSSPWLKFSRAALLGYGIGANSCDAYYPKCPKDEMEILYYLNNHRGGFFRFFSNGDQGQTQQQQQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WER6</accession>
    <name>A0A084WER6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007210-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016712</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WER6"/>
    <dbReference type="STRING" id="74873.A0A084WER6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016712-RA">
        <property type="protein sequence ID" value="ASIC016712-PA"/>
        <property type="gene ID" value="ASIC016712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016712"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016192"/>
    <dbReference type="OrthoDB" id="6239677at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="18409" checksum="C726849773A078B8" modified="2014-10-29" version="1">MDTQTVLTDRKGSVLGTVRSADRTRADLTAPLLPWLDVNEPEASVLPRNVSGWSVATKAHLITPAELAIESSFGEFLAKDSTTKDQTHIWNRLQRDFHCCGYNGIHDYKKVGVPWSCYDPINSKVFNAGCMHVFVKSIEMNMIRVAVVAIASALIQVGVQCSVCVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEZ3</accession>
    <name>A0A084WEZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">AGAP006949-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00016797</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEZ3"/>
    <dbReference type="STRING" id="74873.A0A084WEZ3"/>
    <dbReference type="MEROPS" id="M41.A09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016797-RA">
        <property type="protein sequence ID" value="ASIC016797-PA"/>
        <property type="gene ID" value="ASIC016797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016797"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006771"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000001">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="354"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="772"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="814" mass="89492" checksum="EC8DF62F85BAC1DD" modified="2014-10-29" version="1">MAYRLLTTAKKLESVLIGLNRPHRTVNGTDCEQIIRSLSYLESRSNKTWNEFIHRIQLFCEKPPKGFEKYYKPPGASSSKQANKAEQSAAKDGKAPEQAPPSSQQSSQPPPGATSQKNDWNLGMFSPQPARGKSGSSGGGSGRPIGGGEDGDKEKMLIFGALAGVAFISAIAFFEMGYKEIAWKEFVNNYLARGIVDKLEVVNKKWVRVKLTPGNASDSSGVLWFNIGSVDSFERNLENAQTDMNIEPVNFVPVIYRSELEASSLTGLLPTLLIIGFLVYMMRRSSEMMGGRGGRRGGGLFGGVMQSTAKLINANEINVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKNAPCILFIDEIDAVGRKRGGKSFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALLRPGRFDRQIYVPAPDIKGRASIFKVHLGPLKTGLDKMDLARKMAALTPGFTGADIANVCNEAALIAARDLNETIIMKHFEQAIERVIAGMEKKTNVLSPEEKRTVAYHEAGHAVCGWFLEHSDPLLKVSIIPRGKGLGYAQYLPKDQYLLTTEQLYDRMCMTLGGRVSEEIFFERITTGAQDDLKKITDSAYAQITRFGMNKKVGNVSFDSSQPGDPMFTKPYSEQTAQLIDEEVRALIDRAYVRTTELLTKHRADVEKVAERLLKNEVLSRDDMIELLGKRPFPEKSTYEEFVEGTGSFEEDTTLPEGLTSWNKEKVGESKEDSAKQGDDSKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFU9</accession>
    <name>A0A084WFU9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017243</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017243-RA">
        <property type="protein sequence ID" value="ASIC017243-PA"/>
        <property type="gene ID" value="ASIC017243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017243"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017243-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10312" checksum="1419DD947976AA45" modified="2014-10-29" version="1">MSCRWVGAKDARRRDAMLRPNLAEGDFSVHCQHPSVREVCVGVAYIIPPGSHVLSHLCPPYRAIVPFPGVGAKEFHHHQVHHSGGFPIIYYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFZ4</accession>
    <name>A0A084WFZ4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00017293</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023414">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFZ4"/>
    <dbReference type="STRING" id="74873.A0A084WFZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017293-RA">
        <property type="protein sequence ID" value="ASIC017293-PA"/>
        <property type="gene ID" value="ASIC017293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017293"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013970"/>
    <dbReference type="OMA" id="HPSNYGY"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017293-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="36443" checksum="0CAE2F37C62B01E0" modified="2014-10-29" version="1">MSKVVLVTGGTGLIGKAIESVISAQKPENERWIFAGSKDADLTDLAATRKMFEQHQPTHVVHLAAMVGGLFHNMSNNIDFLRKNILINDNVLLVSHELRVQKVVSCLSTCIFPDKTPYPIDETMIHNGPPHDSNFGYSYAKRMIDVLNRGYNQKYGDMFTSVVPCNVFGPHDNFVPSVSHVIPGMIHRLHELIYVNDAETPQENKVFTVYGTGKPLRQFIYSLDLAKLFIWVLRNYDSPEPIILSVDESAEVSIAQLAESLVKAFDFKGKIEFDTSKADGQLRKTASNAKLRALLPEFQFTDFDVAMKETVQWYIENYARARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG26</accession>
    <name>A0A084WG26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017328</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG26"/>
    <dbReference type="STRING" id="74873.A0A084WG26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017328-RA">
        <property type="protein sequence ID" value="ASIC017328-PA"/>
        <property type="gene ID" value="ASIC017328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017328"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="180" mass="19839" checksum="72A816172CA3061F" modified="2014-10-29" version="1">MEPSEPPTEPKLLLNNTVVDQSDDGNVRTTIITTTTTLNTSGDELPEDLEEQLLKQLRDQQLLQEQQDQHRNGGNQTVIITTTTAEEDPDTGVETTSTTTTQTTTTTKTITLTSDGDFPEDELLQKFTTTTTHTSQPNAPELVKETTVTVTEMVDGRTLDGAAKALNNIVDDFMNQERKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGW6</accession>
    <name>A0A084WGW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008103-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGW6"/>
    <dbReference type="STRING" id="74873.A0A084WGW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017737-RA">
        <property type="protein sequence ID" value="ASIC017737-PA"/>
        <property type="gene ID" value="ASIC017737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017737"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021831"/>
    <dbReference type="OMA" id="TIQSYQD"/>
    <dbReference type="OrthoDB" id="6350415at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017737-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="857" mass="99986" checksum="D5C12B5642C954EC" modified="2014-10-29" version="1">MTVFQLGKDSNNSASESLSSLSLGLDEGCTLQGLIDDLKKEIESKDLVLRDRHAELERLQQELGNRERQLGLCRARQESIDDEKLTLQKKITALEETADDQGRIIAMLNMEKSKLVQQLEDLKETLQQYRDNLQKTSEEKIIIEDECKNQLVTISNLRVALEETKRNGSSSVNVLHELVENLQLEVILLSEQLNDAFKENVAKDNELDQYRDSNLQLRCQLADLSREFGDLKDISDAVDIRQELNDQKQRVFALLKEDVKQLQDQMNGVRGEIVSRQQDLGNLNFFREKCAEMERLHELELSQQRTKHSNELKQLRREIESLSNQLVSSSDTSQQHEQTVEALATLQTTILKLDEHNRVLQKTIQSYQDSVVQLEQQLGGSQHQLSTTRQELEELRDRCNVQEDKLVALKSEKDRIAGELVVQRRMCKCGINSNPGSRERAKTPLSHSLQKQLAQKTLEATRAQEELAQRIEEWKKRETEYVNHRIQATEQTTDLIEQLSEFKGRNSNLEQSGYMKDELIERLQQSLRDVNRKLAIKQDQLVEVEAKNVSLSDALERARQDALACEKRCMEELSNVRRCSMDQKNQLQQYERQINRLRAEIDNVREKSEQMSSERDALRDESQGLRERLASFEGKQSALCEVIKSNQDELAFKSSRVMELEEMHRQLNQNYQQLKSFHEDLSKQFHRGQQEIEQLKESSKKLLEFKQQTLATKELTRKSVAEWKEREAQLSQEIVRLKKRTEMLDQDRAKLIGKLQEYHRDNTILGRRVHQQQQQSQQQPPPRQHSPYDDNRRSYNLTPLHQTFYPPEAYKLVRSSSDPNCNEPDELLQKVELTCNQLQQIRKFWHQGLKEVFPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH22</accession>
    <name>A0A084WH22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP009254-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00017720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRRC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023778">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH22"/>
    <dbReference type="STRING" id="74873.A0A084WH22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017720-RA">
        <property type="protein sequence ID" value="ASIC017720-PA"/>
        <property type="gene ID" value="ASIC017720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017720"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002726"/>
    <dbReference type="OMA" id="ELFPDQW"/>
    <dbReference type="OrthoDB" id="4968544at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000017">
        <property type="entry name" value="Protein PRRC1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276:SF2">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="5">
        <location>
            <begin position="183"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="39403" checksum="D88DF517BFC18526" modified="2014-10-29" version="1">MSDIKKKTGNILSNVSPPSELPSFITANVATAGTDLTVTQSNKPPAADDGAKKDETEPFIPTTFSPAIPPSKDTSLLLAADRPMAVDPVHRDGESVAEPVNRDFASMILNPEPVAAALSPITQGGSALFGWMKGAVSGSGILQKVAEKAKNSVDTIVTTLDPQMKEYINSGGDTEVIVASDKDDKVRPIREAFQTVFGKATVIGLPAQAAAIAAQPVGFTAGLKGAEQRINSIRAENPRVDDHLPVVAIENFVVELFPDQWFDAGVILLFDYAKSILLKTVTQMTPIPLPVITALQADTPADYLLKDTGFAVTVGSIMARNLNHLFVSNGIGKYAKELYLHEGVGSSDHHGFLYALFHCGNKSDPKGKDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHR1</accession>
    <name>A0A084WHR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011797-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHR1"/>
    <dbReference type="STRING" id="74873.A0A084WHR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017768-RA">
        <property type="protein sequence ID" value="ASIC017768-PA"/>
        <property type="gene ID" value="ASIC017768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017768"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019799"/>
    <dbReference type="OMA" id="PNGFYQA"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000338">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="36748" checksum="321286B5D85BF257" modified="2014-10-29" version="1">MSLNTAHANNGVLIHAGEGILIFSDHVTIEFTGHDNPSMKGTKQGRVYLTTHRVIYNSKQENDSVRSFSMPFVSMREVEVEQPVFGANYIKGKVQAQQNGNWTGEAKFKIIFKHGGAIDFGQAMLRAASIAQRNAGTAPPPPYTPPGGAWYAAPPPAYTPNAYGYGWVPGASVFPEQPQPNSIYMHDSPPPYPGIVPQQGPGGYPQQPGAAGYPQQPGAAGYPQQPGAAGYPQQQPGYQYPPQQQQQFAGGFMPQPTAGGYPMQAGFATGPGAGYPNGNVGYPQPGSSSGTMGFSAPPQPPPNSKEAEAAQSAYYDPNRPQTAYVPPPAYYEPPPSYSSLNKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI66</accession>
    <name>A0A084WI66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017941</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI66"/>
    <dbReference type="STRING" id="74873.A0A084WI66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017941-RA">
        <property type="protein sequence ID" value="ASIC017941-PA"/>
        <property type="gene ID" value="ASIC017941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017941"/>
    <dbReference type="OMA" id="QNLFCWE"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785075" evidence="6">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="16619" checksum="98526FD36B8CBCF5" modified="2014-10-29" version="1">MSFQKAALILATVFLVLVPSSRAADFANCANETAIGEFSKVEVSNCDDSQAACVLKRNSNATISITFTSSEDLTELKAVVHGIILGMEVPFKLPNDDGCNGSGLNCPLTKDTSYRYTTTLPVLKQYPKVSVEVKWELKSGDKDVVCVLIPAKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIC4</accession>
    <name>A0A084WIC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Short neuropeptide F receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00018006</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIC4"/>
    <dbReference type="STRING" id="74873.A0A084WIC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018006-RA">
        <property type="protein sequence ID" value="ASIC018006-PA"/>
        <property type="gene ID" value="ASIC018006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018006"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013385"/>
    <dbReference type="OMA" id="DINGWRF"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="111"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB49968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="570" mass="62074" checksum="77303E98CFD72669" modified="2014-10-29" version="1">MLTPVSSLVRLGAAMTSLIPAGPAMASVVLGFVEPSGLPMVSRASTTAFPPISGQTNASLTNFTLDEPVLLGWVNSSTVAPPVGMDIMSNKLLQIVFCVLYSSIFVLGVFGNVLVCYVVFRNKAMQTVTNLFITNLALSDILLCVLAVPFTPSYTFLRRWVFGKLLCHTVPLAQGCSVYISTLTLTSIAIDRFFVIIYPFHPRMKLSTCITIIVLIWSFAIMVTMPYGLYMKLHGVASNATDSPQGTLPSAMYCEELWPSEEMRKTFSIVTSILQFVLPFIIMAFCYVCVSIRLNDRARTKPGSKTSRREEADRDRKKRTNRMLISMVAIFGISWLPLNVVNMCNDFYSDINGWRFYNLIFFIAHLTAMSSTCYNPFLYAWLNDNFRKEFKQVLPCFDPSRGRAGTVNGNRGGGGGWRSERTCNGNNDTVQETLIASSQALPSSRSSQQQSQQHVSSGSSQTHHQPTVDSILLSEVGPPLPPPINSNVLPSVQSAETVVLPSGVLETPFDVQLVPGVRNGTKLEGATTLAATSASVGNGGLNHGSSNSKLSSLILINDGTTPDSKVPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIW9</accession>
    <name>A0A084WIW9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018225</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIW9"/>
    <dbReference type="STRING" id="74873.A0A084WIW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018225-RA">
        <property type="protein sequence ID" value="ASIC018225-PA"/>
        <property type="gene ID" value="ASIC018225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018225"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000630"/>
    <dbReference type="OMA" id="TPLWNMP"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12439">
        <property type="entry name" value="RRM_TRMT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034262">
        <property type="entry name" value="TRMT2A_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="627" mass="69933" checksum="704FD49DF0C59104" modified="2014-10-29" version="1">MDIENVLVVAEQAKDCDGLDKTEASENVLDSVVDKEAEKVPTVAREAVIEEPQDSKEGNKNPESDEYAYLDATGFTSELFKIEVRGLPKYYGISELKKLLNVKMNLSTNKIKIMKPGSPFIFICFRCQEDREAAIKALDGFKWKGKTLSAFEAKPSPDPLVRRRKEASAAEGEPLNTKRRSVEACATALAYLPYEEQLLQKQSEMENVLQKFGKELWSSVPSLRSYIEKQREHNNGLPCALEPIRPSPVQNGYRNKCEFSIGKDGSGVKRVGFRVGSYSNGFLEVEPIKDLKHIPDCMKQTVSLFEEFVQASNLEVYSAETYQGYFRQLTVRMSNATGQVMVVVGVHLQELPLEEQKSLKDSIVKCLTSEAGKNAGICSIYFEVIQKRQQGQFTNPIEHLYGETHIEDTILGLKFRISPQAFFQINTPAAEVLYQCAIDLASPDKNTSILDICCGTGTIGLCFAKHCKQVLGVDIVAQAIEDAKHNAERNGIENCKFFDGNADDLIMSLIRHANIIPAQHESLLAILDPPRAGLHVRSITQLRNARGLNKLVYVSCSPQSAIKNWVDLMRPCSKQLRGEPFIAKRAIAVDLFPHTPHTELVILFEREPESGTVEETIVPNTDSIVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN31</accession>
    <name>A0A084WN31_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00019700</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01024557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN31"/>
    <dbReference type="STRING" id="74873.A0A084WN31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019700-RA">
        <property type="protein sequence ID" value="ASIC019700-PA"/>
        <property type="gene ID" value="ASIC019700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019700"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007887"/>
    <dbReference type="OMA" id="ENHYCSQ"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1020:FF:000001">
        <property type="entry name" value="Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00613">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="14">
        <location>
            <begin position="463"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB51625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="659" mass="75773" checksum="E157B57247C278AB" modified="2014-10-29" version="1">MAAINQALVLALESNPKESYVVATETLLRLLDNIIREPQNAKYRTVRLENQSIKEKLLSAVGMKQLMLAIGFIEANGTLTVPSNVLLANLRKYREFIHERKELIKNPPKAAPTASITTNTNGGTVANTILPSGSSMMFLPAGSGTGTKQEERKELIDIKASRPFHARIEFPRVLQTSNTLLLQLELLSDQVMQYEDELLLVGGRSVIPIDELTARAKDKLIQWQRLLHGSANGEQEPSHEDLLLEELTAWFKADFFTWVNALPCLVCGNEKTQLVQSIVIDGVRVEVYKCCGQLRHFYRYNDVEKLLQTRKGRCGEWANCFTFLCRCLGYDARYVFSTGDHVWTEVWSDRRQRWIHVDPCENVLDAPLMYEHGWKKEITYVFGFACDDVQDVSWRYSSDHEAMMQRRNACTEKLLLEAIRKLRVKRRAGANCTQERLALLRRRTFDEGIQMLANAGRMPTPAEREGRSSGSLEWRLQRGEQQVNTRYMFIPTEEEVQAKQFNIRYSCALDCYERFLKGASNRVNEKITEKSKGWESRQFLSKNIFRKEEHDWKMVYLARTEGTDEATIEWNFDFSVQGLRVKQVELQFGQETYEGAKVELYYIKSDGSQSQSLSSLCECGKFTLQARLSGGTSWQHAQLFRQSKSAIDEYPFEMNIVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN59</accession>
    <name>A0A084WN59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007416-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019734</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024568">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019734-RA">
        <property type="protein sequence ID" value="ASIC019734-PA"/>
        <property type="gene ID" value="ASIC019734"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019734"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000247"/>
    <dbReference type="OMA" id="KNISDRC"/>
    <dbReference type="OrthoDB" id="5973987at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019734-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="14731" checksum="85FBD8A245BD89BC" modified="2014-10-29" version="1">MDDAGNILIRRYSKSNVYVKSTANQPNEETAIGADILKLPGQAIESEKIVKLFDMKKFQSNVNRELRRAYPDRRRLETQCLSAIAFVKSENDILDCPVWVLIINVVAMDMLKSKLPPGKYQKNISDRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNB6</accession>
    <name>A0A084WNB6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyprenal reductase</fullName>
            <ecNumber evidence="2 9">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019799</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="2 9"/>
    <dbReference type="EMBL" id="ATLV01024582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNB6"/>
    <dbReference type="STRING" id="74873.A0A084WNB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019799-RA">
        <property type="protein sequence ID" value="ASIC019799-PA"/>
        <property type="gene ID" value="ASIC019799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019799"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024365"/>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="36152" checksum="198147570F51E87C" modified="2014-10-29" version="1">MFSWLDLRSINLINFLLVNLIITVVVLGGLLATIEKHLPTAIRQTFRYGKHALKGTPDRLVSLLEVPKAWFKHFYVFAAAWSLAGFACMAQAYVTGKPAPDFVIDFLDMMATNKRGVRTTPTETLIAMTLITMQCLRRFYETWFVQVFSSTMKINLSAYLVGYIHYFCTVAAILSQAEGFTRAGPLTQPANGYRFHPDVSLALAIGLFYYAWFHQYRSNVILANLRKDKTGKVISQKHSLPSGDYFELVSSPHMFFEIVMYVVLFGVLYRNTSMVYVLLWVVSNQVMNAWLTHQWYMENFPNYPKNRKALIPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNB8</accession>
    <name>A0A084WNB8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">superoxide dismutase</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00019801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01024582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNB8"/>
    <dbReference type="STRING" id="74873.A0A084WNB8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019801-RA">
        <property type="protein sequence ID" value="ASIC019801-PA"/>
        <property type="gene ID" value="ASIC019801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014111"/>
    <dbReference type="OMA" id="CKSTGPH"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000010">
        <property type="entry name" value="Copper-zinc superoxide dismutase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785099" description="superoxide dismutase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="85"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="23393" checksum="4009B4A87E0DB496" modified="2014-10-29" version="1">MAPLWKAIVQMSLLGAVSWMPICGQLTDDVEIIDPTVGFGPGRGTGSGIPLGPRGFRGFEILPRPEPSWKAGATLVADNPEQQITGTITFRQWAPGHVETAINITGLPVGKHAVHVHAFGDMREGCKSTGPHFRSSIIGNIDVKEDGNAMIDFHSPYINLFGFAGIVGRSIVIHEKPSEVYRFPDLSINNPISFQGEEDTVGARIACGIITILDNVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNU8</accession>
    <name>A0A084WNU8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020052</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024729">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525359">
        <property type="protein sequence ID" value="KFB51892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020052-RA">
        <property type="protein sequence ID" value="ASIC020052-PA"/>
        <property type="gene ID" value="ASIC020052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020052"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7771" checksum="4F51007CC6924C39" modified="2014-10-29" version="1">MFCELPLKACVPVLCEDSLQDADEVLRRAQQHHRNGDNVIVPSVEKCSSKQQFHHHPPSLNLQHRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNV4</accession>
    <name>A0A084WNV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020058</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525359">
        <property type="protein sequence ID" value="KFB51898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020058-RA">
        <property type="protein sequence ID" value="ASIC020058-PA"/>
        <property type="gene ID" value="ASIC020058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020058"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020058-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="17740" checksum="4D8223BFC33ADBFC" modified="2014-10-29" version="1">MFSPVGSNNPTSVSSGADSTTRKVLLAGSRCPTKRNGHDFFIALVVPCGNIRRSNRTITTTHKHTHIVFSFLLFLQNRENGSVEELFENPVGEHKSVSNAYLIRKQSGPTLKAYVKGVWLHLGESPHLTYTYEMGLGMLEILSETTTVRTSNGYLLTALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQD0</accession>
    <name>A0A084WQD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Glutathione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020669</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025520">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525392">
        <property type="protein sequence ID" value="KFB52424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020669-RA">
        <property type="protein sequence ID" value="ASIC020669-PA"/>
        <property type="gene ID" value="ASIC020669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020669"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="15904" checksum="5F5E45E861DA90A8" modified="2014-10-29" version="1">MREFRLIARICYDRVANSSEVFNPPPRAKRFTFARICIRSHAARRDGGIRRSGVEKRDPGVASVDPIRLTNVPGILANRTGGRTVEVTPLAIAQLRCLKRKTLPPGTKNVEKNSWPFSKRGKGVARGGVRSRNTRLSIDAEGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQM4</accession>
    <name>A0A084WQM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Serpin 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020766</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQM4"/>
    <dbReference type="STRING" id="74873.A0A084WQM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020766-RA">
        <property type="protein sequence ID" value="ASIC020766-PA"/>
        <property type="gene ID" value="ASIC020766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020766"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005671"/>
    <dbReference type="OMA" id="TMYLIQP"/>
    <dbReference type="OrthoDB" id="9518664at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19597">
        <property type="entry name" value="serpin28D-like_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000035">
        <property type="entry name" value="Serine protease inhibitor (serpin) 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="6"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020766-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="396" mass="44391" checksum="7A9C139C9E8281BA" modified="2014-10-29" version="1">MLDFMIRISRTLTQQQSKTELFSPVSIATVASLLFLGSKGTTHEEFKKVLTPAGMNWNHYHQRYSGVLANLVSQNPIDSKRDQWRRQTCPINDDYEDEQEAPEPKSQIIRLANGVFYQPSLRMEQKYVSVASGLYGALVEPIDQQNSAAKINRWISDMTAGKIPNMLDGPLSPSSSVVLVNALYFKGKWKTQFEPLVTRPAPFFPHGYDKPSYPVTMMSLSGCLPFHKTRNGVSIVGLPYRDDSSTMYLIQPTNSSETAIRRLQATLTGKTLESMIAQMKLQTTMVRMPKMHLKSSFNLLQSFQKIGLTSILSPAKSNLGQMINENSTQRPYVNQIMHKVDLVIDEEGTEGAAATSALVDRMGPQQTFNGNAPFLLYLRHDATGLPLFYGPIFDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQM5</accession>
    <name>A0A084WQM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP009211-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00020767</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQM5"/>
    <dbReference type="STRING" id="74873.A0A084WQM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020767-RA">
        <property type="protein sequence ID" value="ASIC020767-PA"/>
        <property type="gene ID" value="ASIC020767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012799"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785321" evidence="10">
        <location>
            <begin position="25"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="100"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB52519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="40734" checksum="DA75BEF9776AE122" modified="2014-10-29" version="1">MKATQFSTVCVVFLLVMIPVPVMGAIVRECKSEERCVQIALCGQYLHYVNEAPKNWPPSVRQEAINQLCEVQVSVNGSKVYYICCSQQEILCGVSRVQLIAYGQQARAYAFPWMVLLESSLSAEPACGGSLINDRHVLTAAHCVKARTITAVRIGVHDLNADEDGCNDRIRFADDYGIIDEDADNKADEYSASCGPPEQRIPIETIVTHPKYSPRSKRNDLAIIRLRFPAVIGYSVIPICLPLTDQLRAYRPSDSFVTGWGVTETGERSAVLRYTVLPTLPLPDCAMRIKELDRMIVLDEGHLCAGGNNKSAHCQGDSGGPLQYISDSTRFVLQGVVSFGVKSCGTKIAPGVFANVSNFIDWIVEEGKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQR4</accession>
    <name>A0A084WQR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010775-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025675">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525397">
        <property type="protein sequence ID" value="KFB52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQR4"/>
    <dbReference type="STRING" id="74873.A0A084WQR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020801-RA">
        <property type="protein sequence ID" value="ASIC020801-PA"/>
        <property type="gene ID" value="ASIC020801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013696"/>
    <dbReference type="OMA" id="LNGMYYG"/>
    <dbReference type="OrthoDB" id="7743108at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="21485" checksum="2BE8F88EF688189A" modified="2014-10-29" version="1">MISVYCEQSAYGGGWIVFQHRFNGEEDFYRNWVDYRDGFGSLDGEFWLGLENLHQLTSSRKHELMIVVIDTRGNYGYAHYDHFVIDDESENFKLKIVGRYEGTARDTLKQRLGDKFTTKDEDNDGWIYGNCAVSWKGAWWYDSCGSSDLNGPYAKSRKQSIAMTWDNFSGRSLTYTRMMIRHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQV2</accession>
    <name>A0A084WQV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000554-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020842</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525399">
        <property type="protein sequence ID" value="KFB52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQV2"/>
    <dbReference type="STRING" id="74873.A0A084WQV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020842-RA">
        <property type="protein sequence ID" value="ASIC020842-PA"/>
        <property type="gene ID" value="ASIC020842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020842"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010610"/>
    <dbReference type="OMA" id="EFNSYRH"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000006">
        <property type="entry name" value="Putative_zinc_finger_motif_-_C2HC5-type /ASCH_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056994">
        <property type="entry name" value="TRI4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23135">
        <property type="entry name" value="TRI4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="396"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="548" mass="61984" checksum="60755618ABFECD90" modified="2014-10-29" version="1">MNQWIREELSKCLCFEIPDAMISYIHTIQDSHEIDEYFRTLLDFSNPEHVTFLSELKAKLRHRKNDSGSANVQQAKQSSSKPSAQGGKSKRANGNEAQQASKPTANSGPAPVAAGQGTMQTGAQTTSKKKTKFVNLYGQDGELANVVMLKGRHHCDCQASKHKLVNNCLHCGRIVCEQEGSGPCLFCGSLVCTEDEMRLIESSSRKGDSLRRSLMEQNRPAGWEEALATRNRLLEYDRNSEKRTTVIDDEADYFKTNSVWLSDAERQKLETLEAELREKRHASRASRKITLDFAGRQVYDEAQLTAEMEESIIKKALETKENTLPNDYTAQYTNLDSDMDLHPMFNGPVPTFVHIDNLSNQQSAPSPGVRQTGFDGVYSRVQDKEFLEMSDMRHCLSMHQPWASLLVAGIKRHEGRTWYSSHRGRLWIASTARPVCPDTVRELETFYRTHYGPDEAESLSFPSQYPSGCLLGCVTVQDCLPQEEYRKKYLTGESDSPFVFVCVEPQELPIRFPVKGEHKIYMLDAKIHQAAVKALQKQAKQRDTEVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR91</accession>
    <name>A0A084WR91_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00020997</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytospin-A family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01025994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025996">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026000">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525404">
        <property type="protein sequence ID" value="KFB52735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WR91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020997-RA">
        <property type="protein sequence ID" value="ASIC020997-PA"/>
        <property type="gene ID" value="ASIC020997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020997"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001253"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022302"/>
    <dbReference type="OMA" id="WQKMANA"/>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="1832"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="2184"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="2495"/>
            <end position="2658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="655"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1671"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1736"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2047"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2418"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="222"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="797"/>
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        </location>
    </feature>
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        <location>
            <begin position="2482"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB52735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020997-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3111" mass="344346" checksum="EB4FFD5F0E00929E" modified="2014-10-29" version="1">MIKLKSLFRRGQGPSGTKHQSSSSSSSTAASPGSGALARDAGTGGITSIGGAAAGGGLSANGGGALLKSAASVSSLEYSIGAKPAQSTRGGAGGLGTQQRFNGSREKLDHSHHHHHHHHHHQQQQQQQQYPHHPQHTRTASASQMAQMAQHHHPSGTASTNHLNKFPSGGDGGLLVQERAVDAGSGGMSASMEQLTAISFAGPEQMAAAAVAVSPGKSSRRVAELQSHLERLQTENRHLEEKVHEMTNCQEELLLLRDEIVKLKASHEQSNSELHRLLNENESLRDRLKTVVQSPLSDSEKQQLIRNTQRLHSSAPASIALPNNMDAEGTPCVTPDWDKQSSSSEIAVACLQDKIIQHNYTNPAFCQQSEYYSSAPTTPAAAKTAGMAGGGGSLVSISAAATMTAASCTRRNEQLTRSYHRISSKVVNRQHSLASFDRRTAGGGGPQVAAPPIPGKPLVNARLLDRYGPVGSTGSAPQSQPIASLASAGSTSGSRYALVPVEEIPFNVVRKYSVVDERQLSLGGGGGGVGASRSDEFLDRVGSVPNLGGNGRQRFQHDRTMEEEQQEGDGEDAEEEEEMHNLSDHFPVPFCCRIFSCNLFKTDGAQGWLYYQHVNARRFEMVPTEEDEELVDENQEIIQMHNGRAHRYAIIPSVPDDEDETCLSNGDINGYSASGAEDPTAIHRSPARTPSARLNQQQQRAGSRRETPKPQLPPTPSQQQQQSLTLTPSKAATHPGQGETTPKKNPATLKLHELLTTPQKKNTPQWRNQPPPPPSPFTMTPSTTPQRRAPAPPMMVSSTPKQPQHQQQLQPIQQSVQSPPTTAIISPRLNSDIYSEKPLPLDPEKSVWGQGVPIGHKSWQKMANASATIGAVSLMLILCGFMNSGLSLYMTAKLGREFYLDMGILAGFSAIALGILGFKSRQCDWLPNRNYMSGYVLVTIFSLLNCCAEVILMTMHPYPGTPLNDVTTGIILGLSSLIILLISLGAITSRWCRAPPPDNRVDTEKLEDSRTQIGTLQKLLLREPSPQDATPTDREQKLVDLLKSAQDEREGLMLKQEELNGELNELKGILDERTAEVSRARARVSLLESSLDAANAEKKDVNAQLMESKEDASVKLIEISRLTTLLENARAKIDELEQDRAMGDKTDLEELLDTARKEKDQLETQVASLQEQVSISQCEVQKLKDQLARLNEECKVVRNNAKCLISDLEYKNETVSQEKQKIATEFQQLQESVNELQIQNKCLLEDKCQLETLLSETQKHLGETERKLMEKTEELNQESRLRKQEADEWEHFQSDLLMTVRVANDFKTEAQNAREKLALDNKALREKVRVLEQQIEQLNKQSLKGMGNADDVQLSYERLNVLKQDLCASTENLNMFDRNVDEFSQRVQLLRKQMSSFSFDRKLTPTSDVPAAAENWQLKGKSTVPPPALPDSDSDVPPPLPKSKPPKMVVRFADAASSVESSESHDFSESDLEESELMPAARKATPFGDEQRSYTPTSETGSGSANDDDLSDDAGEYRVNPPAFRPIAASLSTESLTTNSSFALFKPIPRFASKSTQDLRSTARGEDFEAGSQRYHGQRGLASANFGSGLFYSKSTDDLILPDIDRMSQKPSSNLSKFRKFRYERSISGSSLNNLAKMERLELAPRHEEETMGNMQKQHESNALRAYRTLEGSDSSEKTTSVGKISNQLQFTTNLPNVQHETKPEIRKPQPLPRTDSEQSLAMGQKTTIVYQISMQSPTTHVQSSLPTKSPLREQQQPTVGSNVNSNSKPIASADSVLLMKKSNLITSNNGCNAALNPAIISHKTMDFVRRNSYNDISERKDPLNALVKNGGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDGLALCAIMHTYLPDRVPYDKLNQNDKRRNFSLAFAAAESVGIQTSLIKLEFAAPQEYGAEDNANALVLPSKKRATKIKSDKTVVTKILSKKQRKRLEKIVDQKKKKENRSNLIASLIQVQATKEELSGYRKLSDVQTKGLKQRFKEQKFGVTMVEKSVSKAKDQSVAKLRSLVGSRRKRLALLRQSVRLPGDDEDEEGEKTERDPNVVGLDESSSSEEEEMDEEDSTSEEEVVKSEEAVGWTVEEKNDNATQPTEDGEKPANLDDDVVEIQIKPEEAPKMATPAPAIVDRKPATYIHVERDSSIQAARLKLPILAEEQVIMETISENKITILAGETGSGKTTQIPQFLYEAGYAERGLIGITEPRRVAAISMSKRVALEMNLSTDIVSYLIRYEGNVTDRTKIKFMTDGVLLKEIEVDFLLNKYSCIILDEAHERSVYTDILMGLLSRIVRLREKRGTNPLRLIIMSATLRVRDFTENKKLFLDVPPVISIDSRQFPVTVHFNRTTPADYLREAFLKTVKIHTTLPDGGILVFLTGQKEVNTMVRKLRKMFPALDVGERSTDPSGGERREEAVVEDEDDFDNILRGKKARKKSQTQGKKNSRPSVMVPRLPQIDLDAYDLPHADDTEGDLRDGNDSGSELEDDDGMDLRAEDDLDGVSELKKSQPLWVLPLYAMLPPDKQQRIFQPPPPGARLCVVATNVAETSLTIPDIKYVVDSGRQKTKLYDKTTGVTAFVVTYTSKASANQRAGRAGRVAPGHCYRLYSSAVFNDEFIEHAPPEVQQKPVDGLVLQMKCMGIDKVINFPFPSPPDPVQLQVAEQRLLKLGALEEIILQGDGPGKKAQTLTRVTELGRTMAAFPVAPRFAKVLALSHQHALLPYAICLVAALSVQEVLEEISLTEDGPQNEGSKRWRQRRKGWAGQGESLLLGDPMILLKAVGAAEHANSKGLLEAFCVENGIRVKAIREIRKLRVQLTNEVNANLREMDLTVDPNMPPPTTLQIRLLRQLLLIGMADQIARKLPDTEIKLKADARRLKAAYNLPTIDEPVFLHASSVLRRELPQWVCYQEAYETIVPAEVAGDGSKTKMFIRGITAIEPEWLPKFVPNVCNIMDVLEEPIPPAYNAENDSIECYVKATIGKTSWELPSSLVEMPRNMLRCKYLLKFILIGDIFKQLKQFRKSLLSSPDSVLKQYASAVPRIDAALKVLFANEVFNASRLRDLWRADSKFFLNEYKGFLPISCQDDVAKLWPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRE7</accession>
    <name>A0A084WRE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021058</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021058-RA">
        <property type="protein sequence ID" value="ASIC021058-PA"/>
        <property type="gene ID" value="ASIC021058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021058"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021058-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7332" checksum="D506D8F5C2ABD775" modified="2014-10-29" version="1">MQAPGEILESDFCWYGFAGKNRFRSRDLDVAALAGIVSIGSESVPTLCARVGPVSPNFARSRREGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS55</accession>
    <name>A0A084WS55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021350</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021350-RA">
        <property type="protein sequence ID" value="ASIC021350-PA"/>
        <property type="gene ID" value="ASIC021350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021350"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="116" mass="12419" checksum="51CE0262E19BC4E6" modified="2014-10-29" version="1">MGSNNVRVWGAVGIEANGEFVGGFSFVCVCSVSVVRSISTRGYVACGKTPQRNESRIECRAQGGGVREKGMEDAECTMRSLFARSLQSSLASLLLVLLGAAQKDDARRTNRTESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS92</accession>
    <name>A0A084WS92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021378</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525413">
        <property type="protein sequence ID" value="KFB53086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021378-RA">
        <property type="protein sequence ID" value="ASIC021378-PA"/>
        <property type="gene ID" value="ASIC021378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="B2636EF81BE6B589" modified="2014-10-29" version="1">MPPWVSRAEPIPWTRLRTGSGGDGKIRSVHGVQRGPVRQARRIPPPSRVWFARFFDRLRSTPSDDAFALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTH2</accession>
    <name>A0A084WTH2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aldose 1-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021744</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01026892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTH2"/>
    <dbReference type="STRING" id="74873.A0A084WTH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021744-RA">
        <property type="protein sequence ID" value="ASIC021744-PA"/>
        <property type="gene ID" value="ASIC021744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021744"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012235"/>
    <dbReference type="OMA" id="IYHHISR"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="435" mass="47940" checksum="23EA10C1DB22BF1D" modified="2014-10-29" version="1">MSSGVEHRQGDSKPSSVSVTIKPIDRLESRGSQVESYEMANESASVPPVTLTVDGFGTVKHPKSGAEETVKRFTWQNRHGMSVQVITYGAIITSMKVPDRTGRVDDVVLGFDDIPGYQTKNNPYFGATIGRIANRVGGGRFMLNGIEYQVTRNFNNRHQLHGGAIGFDKYNWEAHVDGTVVTLSHLSPDGDEGYPGAVMVSVRYQLTEDNRFEALFKAVSTKPTPINLTNHSYFNLAGHATGHEEIYRHVVSINADKITDTDSDSIPSGKFICVGGTPFDLRIPRELGPAMSKTVAEGFDDNFCITKGTEQGRTFTARVVHPHSGRVLEVYTDQPGVQFYTSNFMPDPNKNIRPKAVNAAEYYDVTRLEPVVAEGASDPPIRGKAGAKYFKHGAFCLETQNFPDAINHDNFPSSVLNPGSEYVHEVVYKFDVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA03</accession>
    <name>A0A084VA03_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000212</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000960">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523925">
        <property type="protein sequence ID" value="KFB34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000212-RA">
        <property type="protein sequence ID" value="ASIC000212-PA"/>
        <property type="gene ID" value="ASIC000212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000212"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013927"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11713" checksum="72EAA201A36C5D38" modified="2014-10-29" version="1">MDLIKQLIADTPIEEDPEEESCGEEEERHRHRWAHLVTEADLIRTLRDIVTMVENHPGLQPPTEMVVAVENFSKGRLGLQMAYAIIVDENYALICKALQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBB4</accession>
    <name>A0A084VBB4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001448</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006317">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524352">
        <property type="protein sequence ID" value="KFB35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBB4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001448-RA">
        <property type="protein sequence ID" value="ASIC001448-PA"/>
        <property type="gene ID" value="ASIC001448"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001448"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001448-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6499" checksum="10E21E3130CB2348" modified="2014-10-29" version="1">MLPADTANSWQRHDVEPTKRPPKTEKIEATTRHGHKEPQMTTANPANDCCGLFAELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBE5</accession>
    <name>A0A084VBE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006157-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001515</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524368">
        <property type="protein sequence ID" value="KFB35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBE5"/>
    <dbReference type="STRING" id="74873.A0A084VBE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001515-RA">
        <property type="protein sequence ID" value="ASIC001515-PA"/>
        <property type="gene ID" value="ASIC001515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001515"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004967"/>
    <dbReference type="OMA" id="AFLPNTW"/>
    <dbReference type="OrthoDB" id="7763049at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001515-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="267" mass="29247" checksum="084AE91928A1F236" modified="2014-10-29" version="1">MRAMVAPWTRAFPALSEPDGGQTKLRRRGLSSEVERFSAAPTTQQAKPTGSFEAVAARPRDYAREVVTGSSLSSPKLVASQNARPLRFWLHLMGIAPSVTVDQVIASVQRRLGTDDVIAFSLLAKDVNPATRNALSFKVRIPMSCSEKALSAETWPTGIRVREFVILPRHENRNRQPSPSQLDLPLSPLSSAGRQDTEFHQHTAPQNVNKTLIHSGTPTTSTPGTTSFTASEHTTLPAVDPPRKRKRGPAPDISPNQPKLDSFFRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBN1</accession>
    <name>A0A084VBN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013482-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001891</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008350">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524467">
        <property type="protein sequence ID" value="KFB35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBN1"/>
    <dbReference type="STRING" id="74873.A0A084VBN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001891-RA">
        <property type="protein sequence ID" value="ASIC001891-PA"/>
        <property type="gene ID" value="ASIC001891"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001891"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012983"/>
    <dbReference type="OrthoDB" id="551053at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001891-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="22679" checksum="48DCC1722B6FE5B0" modified="2014-10-29" version="1">MPEEAAGSSLREKDRERCDLLKHLNELCHGIDQEIHSHRQEHERVRATLQELYERGREGSPGPAVAHPFSEPDYKRVSDEVIRNQQNQIQLIKEEKDTFEKLWKSSQRTIRILELEIHEYRRQLKQPKSIHDLRQQYTAAVQLLEQNLSGVRKALGEKIDENRHLQQERAEALERTAALEKGAEGKRRRGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBZ4</accession>
    <name>A0A084VBZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Transmembrane protein 53-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00002238</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01009878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524552">
        <property type="protein sequence ID" value="KFB35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002238-RA">
        <property type="protein sequence ID" value="ASIC002238-PA"/>
        <property type="gene ID" value="ASIC002238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002238"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022748"/>
    <dbReference type="OMA" id="VECLFWR"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002238-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="35476" checksum="D9A96C89435352F8" modified="2014-10-29" version="1">MSAAYGTRMEPDYPLDDTLEYFIKFPSPNFRSDTQTAESDYVFVCNETNVPIVLLLGWAGCQDKYLMKYSKIYEDRGLITIRYTAPVENLFWKRAGMHQIGEKILKLIYDMNFDSHPLIFHVFSNGGAFLYQHIALALRRSKSPINICGMIFDSAPGDRRIVGLYRAIKAIYGKERRCNMLLSAVMAFAAIILWTLEDAFNYLLNFISPRGYEVQTNPSHNLKYESNAWPQLFLYSKDDLLIPYSDIEKFANYRRRNGVDVRMVCFDRSEHVKHFIRHPQQYVYTVCKFINDCLSHYYSKFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC07</accession>
    <name>A0A084VC07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP003812-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002293</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01009969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524560">
        <property type="protein sequence ID" value="KFB35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC07"/>
    <dbReference type="STRING" id="74873.A0A084VC07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002293-RA">
        <property type="protein sequence ID" value="ASIC002293-PA"/>
        <property type="gene ID" value="ASIC002293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002293"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000489"/>
    <dbReference type="OMA" id="RHITCGH"/>
    <dbReference type="OrthoDB" id="7718158at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="9">
        <location>
            <begin position="83"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="215"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002293-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="445" mass="51069" checksum="12669C9364554A6F" modified="2014-10-29" version="1">MEQEQKRQIIENLFTSYAAKRAELVRQYETNRKKRSKIFLQRLRYQLKRNSEAHRSEWCSTARTVVLDSIPTRKIWKLNRCDKWFREVYEAEGNEAAMLESFRMDKDTYEVLVDALTNDLAPHPLLAAQSCSTEKKVGIGLYKLTSGADYATIGNLFGVHKATVKNCVHQFCKAMVKHFMDVEIFLPNSDEMAEISKSFEEKCDIPLIIGAMGRTHIPITPSAADSKNYANAKKWPSLILQAVVDNNHLFRHITCGHVGCTEEAAVLGDSGLYQHFSNVEMLCQSINENTVKSFIVTDPPYPLLPWLMHGYTGMSLSSEEETFNEHLAKAKIVVDEAFMKLRARFRILQRKIDIDINFVPQILLTCCILHNLLEKRQVPFCDEWTDLLRDSEQKYPQPDGSSATSYTTTVEGEAARDILKEYVQSKYMLYRSIDYGHVYFISGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCT7</accession>
    <name>A0A084VCT7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00002698</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01010863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524621">
        <property type="protein sequence ID" value="KFB35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCT7"/>
    <dbReference type="STRING" id="74873.A0A084VCT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002698-RA">
        <property type="protein sequence ID" value="ASIC002698-PA"/>
        <property type="gene ID" value="ASIC002698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002698"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008523"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="18616" checksum="D40635CD6F530C12" modified="2014-10-29" version="1">MAGSALRRLMAEYRQLTLNPPEGIIAGPISEENFFEWEALITGPEGTCFEGGIFTAKLIFPPDYPLSPPKMKFTCEMFHPNIFTDGRVCISILHAPGDDPLGYELSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDAAIMWRENREEFNKIARRIVRKTLGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD63</accession>
    <name>A0A084VD63_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007378-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00002860</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD63"/>
    <dbReference type="STRING" id="74873.A0A084VD63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002860-RA">
        <property type="protein sequence ID" value="ASIC002860-PA"/>
        <property type="gene ID" value="ASIC002860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002860"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012760"/>
    <dbReference type="OMA" id="WHVPRYH"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="216" mass="25048" checksum="8E0155C40C19A119" modified="2014-10-29" version="1">MRLNENIKIVGRAVILVPYESKHVAKYHEWMKNEELQQLTASEPLTLDEEYEMQKSWRVDEDKCTFLILDRALFDKTGDEIAALVGDTNIFLQSTVEDEELQGPGPNELTNSESRTTGEIEIMIAEASARGKRFGWEATLLMLLFGVEHLHIGHYLAITKDSNTKAMQMFERMKFLETKRTPVFREVTFGCTVDKSWLEWMKNEVGSYTIEPYRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD91</accession>
    <name>A0A084VD91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005431-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00002892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD91"/>
    <dbReference type="STRING" id="74873.A0A084VD91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002892-RA">
        <property type="protein sequence ID" value="ASIC002892-PA"/>
        <property type="gene ID" value="ASIC002892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002892"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011370"/>
    <dbReference type="OMA" id="GIEMRNM"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000300">
        <property type="entry name" value="Blast:Protein disulfide-isomerase TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783371" evidence="6">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="428" mass="49509" checksum="4EF8D62141147899" modified="2014-10-29" version="1">MPAVWKLFISLIFFVTLVNSSRVLELSDRFLDVRNEGQWFVMFYAPWCAHCKKLEPVWALVAQALYNTNIRVGRVDCTRFTAVAQHFKVNAYPTIIFVKGPYDYVYNGDRSKDELMHFVNRMSGPPVQLVTRADSIDILKTNNPIFFTYVGKQSGLLWDVFYSAAEAYQAHGYFYATSVEIAKRHFDVDTIPSALVYKERTHYYFPYSDNFERIEPTHLNETLFRWVNEERFATFPKVTRSNIHHLVQTKKYLVLAVVEENKLSEIAAHEQEFRDMVEIFVHKNKHKYHGRFQFGWVGTPELARSIAMDSLPTPHLIVLNASTNEHHIPEDEPLQLTPEAIEIFLDSIHNQTAPAFGGNSLPVRIYRAWFEAKTSLYEMWAGNPVLTTVLFGLPLGFLSLIMYSICCADILDAEEEDDGADQRHEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDW0</accession>
    <name>A0A084VDW0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Facilitated trehalose transporter Tret1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00003207</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524723">
        <property type="protein sequence ID" value="KFB36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDW0"/>
    <dbReference type="STRING" id="74873.A0A084VDW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003207-RA">
        <property type="protein sequence ID" value="ASIC003207-PA"/>
        <property type="gene ID" value="ASIC003207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003207"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001460"/>
    <dbReference type="OMA" id="CGIQAFT"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015574">
        <property type="term" value="F:trehalose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="472" mass="51631" checksum="5B8C8498913DD326" modified="2014-10-29" version="1">MWTLTLTLLRSKRQYLAAILANLSVTCTGCAMAWTSPVESKLTRPWLSPLSSVPSDTQLSWIGSILALGSLAGPPLAGYIAHRYGRKKALLGSGVLFAIAYILFVTTRTVAQILVGRFLQGCGIGFALAITPMYVCEIATSKRRGTLGSMVQVCMTLGMLFVYGVGPYVGYTALQYILLAVPLLYCAAFSQMPETPHFYIAQGRYADASRSLEYLRGEPIEDLQDEYGAIQRAVEESLRHRATFRELVGDHANRRALFICTGIIVLQQLSGINPVQFYTQTIFEKTGSSLKPELAVIIIGCVQVVASMVTVLTLDRLGRRPYLLISAGGMCVALVALGTYFYLESRRALISFSLDRIAFLPVLSLVVFTATFCLGFGPIAWLLIGEMFAPSIKSLASSVVSSTCWAVAFFVLFFFSSLDAAIGTHWLFWTFAICTAGAFLFTYLFVIETKGMSLPEIQARLNETAPVINDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEI8</accession>
    <name>A0A084VEI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP003680-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00003545</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEI8"/>
    <dbReference type="STRING" id="74873.A0A084VEI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003545-RA">
        <property type="protein sequence ID" value="ASIC003545-PA"/>
        <property type="gene ID" value="ASIC003545"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003545"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002430"/>
    <dbReference type="OMA" id="SRYFIER"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="47"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="549"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003545-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="780" mass="85502" checksum="B1D4C633A226F8BC" modified="2014-10-29" version="1">MKQVELIGDTIVCIWRMRFFLSGSGSETSVATIDDGGTMWSRQQNAVSVRHAFKSYGTKKKPNQVLSNLNMTVAKGTIYGLLGASGCGKTTLLSCIVGRKRLNSGEIWVLGGKPGTKGSGVPGARVGYMPQEIALYGEFSIRETMMYFGWIFGMHTSEIAERLQFLLNFLDLPSESRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEARQAHTIGLMRSGRLLAEESPSCLLSMYRCSSLEDVFLKLSRKQGQANVAPAELNISNNISLSALAFGNKKDNPVYVSQESGVVGLNFHQSKEVLISDSNGSTIAINGLNGSAPGAISQAVECDNCTECSGCSNFTSKGKIRALLVKNFLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPTNLKMAIVNGEMNTTIGADCVFDPGCSFTSLSCRYLSHLNDTIVKEYYSDLDSALDAVRDGNAWGALYFTDNFTDALVARIALGRDADDETLDQSEIRVWLDMSNQQIGIMLNRDLQVAYREFAQQLLRVCDNNPKLGDVPIQFKAPIYGTNDPSFTDFVAPGVILTIVFFLAVALTSSALIIERTEGLLDRSWVAGVTPSEILFSHVVTQFVVMCGQTALVLIFMIVVFGVTNNGEIGWIVVLTILQGLCGMCFGFVISAICELERNAIQLALGSFYPTLLLSGVIWPIEGMPLVLRYISLCLPLTLATTSLRSILARGWSITEPDVYMGFVSTIAWIALFLVVTMLVLKFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF08</accession>
    <name>A0A084VF08_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP007689-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003741</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF08"/>
    <dbReference type="STRING" id="74873.A0A084VF08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003741-RA">
        <property type="protein sequence ID" value="ASIC003741-PA"/>
        <property type="gene ID" value="ASIC003741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003741"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023044"/>
    <dbReference type="OMA" id="WRLDVKM"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="435" mass="48145" checksum="3DA0A5541909AFF9" modified="2014-10-29" version="1">MAVEPINSRVYVGGLGDQATLQNLEELFKDFKPYQDLSLLRGFGFIQFHDEQSAQKAIKAMNGKVFKGRKLNVKIANDNRAKKGLLPRGHPASGPATNRDRSPIDGALLHGRPGDPYGHAVSKRGYLAQPYSVADLSSVYPETTIGPAPHRGAESNDCEIIVVTKELTAYAESIEARLKRAGMTVDLLFPNNDVPIGKVLANRASQGTFYCIVITPENQERNSITVNVLYGIPAEHRNMPTEDAINFIIKNFAEKQRQERAPQMPGHTFHLGGTPAPQPVQPLELHSVPPTQDKHPEAVQNMINLLAANRPLTVLQYERLIKYLTERKETQIRLELGEDVDTTTASALIPPIIVPTKSKIETERELQKKILDIMNKPSIIGFAKSSNTFDHVSSEGKFNSTSLPTSVLLHDVKVQRALDTLLQSQLGHFNSGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF50</accession>
    <name>A0A084VF50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003790</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003790-RA">
        <property type="protein sequence ID" value="ASIC003790-PA"/>
        <property type="gene ID" value="ASIC003790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003790"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783420" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8402" checksum="AAC6F71BBC87B7C1" modified="2014-10-29" version="1">MVDRECRMLVMLVILVLTLAPPPVRGIDIGGLVKVTTISARQLTDYLQRLFNATALPLVRRFERPTENPLAEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFI1</accession>
    <name>A0A084VFI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003892</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012409">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524791">
        <property type="protein sequence ID" value="KFB36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003892-RA">
        <property type="protein sequence ID" value="ASIC003892-PA"/>
        <property type="gene ID" value="ASIC003892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003892"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="17568" checksum="284479D1B9C83E45" modified="2014-10-29" version="1">MVPTHRFGKPFPVVCLNQRHTEAVENAWKGTALLLKRAAWNSAERHGFGFRSARVSTAYSMLVVAGLRGTVRDVNRCTCFDTDRSPAQYASHATVPKYCGIRRWHTHRISYQNTDRTVAHHQARATWLTIDPPSVRFLSNGSPNCHFQHLPVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFJ2</accession>
    <name>A0A084VFJ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aconitate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003898</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012423">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524792">
        <property type="protein sequence ID" value="KFB36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003898-RA">
        <property type="protein sequence ID" value="ASIC003898-PA"/>
        <property type="gene ID" value="ASIC003898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003898"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9851" checksum="821A49ABD97C158D" modified="2014-10-29" version="1">MGDTGRERFVNGVAAGCCPMEHDKYQAHRGTLASVRFRSEVRGFAKPGDTLKPGKRLPMHGSLRGRLRSIAFRKPTTAAGERKRRKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGK3</accession>
    <name>A0A084VGK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003782-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00004304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524833">
        <property type="protein sequence ID" value="KFB37097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGK3"/>
    <dbReference type="STRING" id="74873.A0A084VGK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004304-RA">
        <property type="protein sequence ID" value="ASIC004304-PA"/>
        <property type="gene ID" value="ASIC004304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004304"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020857"/>
    <dbReference type="OMA" id="NYPWIHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF215">
        <property type="entry name" value="FI02019P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004304-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="621" mass="69001" checksum="07740F0BFB92B51C" modified="2014-10-29" version="1">MVFNVLIASSVIKTATVVGSSLWLIPFLLGAISYYRYDRVDPESRVINQDALYAEYDFVVVGGGSAGAVVANRLTEIHRWKVLLLEAGPDENEISDVPSLAAYLQLSKLDWAYKTEPTSKACLGMVNNRCNWPRGKVLGGSSVLNYMIYVRGNRNDFNHWESLGNPGWGYDDVLQFFVKSEDNRNPYLARNPYHGQGGLLTVQEAPWHTPLVAAFVEAGTEIGYENRDINGAKQTGFMIAQGTIRRGSRCSTAKAFLRPIRLRKNLHIAMNAHVTKLVIDPETKHAVGVEFFRGGKRHVVRARKEIIMAAGSINTPQILMLSGIGPKAHLDDVGIPTLQDLPVGENLQDHVGMGGLTFLVDKPVAILQNRLEAGSVTMNYVINERGPMTILGGLEGIAFVNTPFANVSDDWPDIQFHMAPASLNSDGGARVKKILGLKEDLYKEVFHPIENTYSWTIMPLLLRPRSRGWVRLKSKNPFHYPLMNPNYFEDPFDAATLVEGAKIALRVGDAKVFKQFGNRVHRKPLPNCKHHKFLSDAYLDCQVRTISMTIYHPVGTCKMGPHWDPEAVVDPRLRVYGISGLRVIDASIMPTIVSGNTNAAVIMIGEKGAHMIKEDWLGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGT7</accession>
    <name>A0A084VGT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004390</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524839">
        <property type="protein sequence ID" value="KFB37181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VGT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004390-RA">
        <property type="protein sequence ID" value="ASIC004390-PA"/>
        <property type="gene ID" value="ASIC004390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004390"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF9">
        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="249" mass="28150" checksum="5F18A9E504D778C6" modified="2014-10-29" version="1">MNFHPNATVVSSFSLLRGKNXRRFVGALMREENARHVSLASPRIPYRCPVRARSCAYATLSSNFNAIIRAXXXXXXXXVKLKLNIQQLHIRQRQLQLTDYDDNSLSSEEHVLAPVSGCMASPNRPCLTWACKACKKKSVAVDRRKAATLRERRRLRKVNEAFEVLKRRTSTNPNQRLPKVEILRNAIEYIDSLQALLEETPPVHQSTDIPSNGSGSTHSTPQDYMVSVQDLRPHHPVHTRSLRPSVPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHD0</accession>
    <name>A0A084VHD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013325-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004671</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004671-RA">
        <property type="protein sequence ID" value="ASIC004671-PA"/>
        <property type="gene ID" value="ASIC004671"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004671"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783673" evidence="2">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004671-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="10101" checksum="D22F40C7AA9A94E1" modified="2014-10-29" version="1">MKATLLFLLVAALCAVALAAPRSEGKGKEGGKGKGKEAAESVEDGQGGSSEEGGKGRGGKEHGKGKGKGGEKEGAGGRSEGKGKGKPEPKQGKGKEAGKGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHK4</accession>
    <name>A0A084VHK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AGAP001979-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00004583</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VHK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004583-RA">
        <property type="protein sequence ID" value="ASIC004583-PA"/>
        <property type="gene ID" value="ASIC004583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004583"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023132"/>
    <dbReference type="OMA" id="GPCYNDE"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="17">
        <location>
            <begin position="350"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1573"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="1670"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="826"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1173"/>
            <end position="1216"/>
        </location>
    </feature>
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        <location>
            <begin position="1256"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1323"/>
            <end position="1348"/>
        </location>
    </feature>
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        <location>
            <begin position="1939"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
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            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
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            <begin position="519"/>
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        </location>
    </feature>
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    <evidence type="ECO:0000259" key="18">
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    </evidence>
    <evidence type="ECO:0000259" key="19">
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004583-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="2002" mass="214879" checksum="92F0459209DE4994" modified="2014-10-29" version="1">MDESGSSSNDHHQATANGGSDGYAYKNEISLSIGDDDQTSRTNSTAVPTPSPRHVEVPMPAAANGDDRETTNEYAALNRSSPGGKSNGLDNPAFELEKEKRPLSSFGHANEKSLGAVSTNGKTPGEKPLAEAVNLELLNMSLKPTTNGSHQNGGTNGTASTALPVKKDTEVDLGDPYDEYFVPVNEHRKFMSVSFQKPRHGHAVYGRHGRGVDYTGHSVNEPAAGTMDYKQWSKITRGEKLYVTKDKREKKRKNWPFWLLGLAVLLAVIIVAILAGSGVIFNDSPTPVESRKFGETVVSASVFGGKSSPGNANTTSTTAASSTDYPTTPSPPSSTVPPVPPSTEEITVYVPNTLEGQITLTNLEFLDDYRNPNSSAYKSLAMELEEEIKDTLSTPDARGPIYVKILNMKPGSVVVDYRVSWEANTMEMSEDTMKHRLSNYLQQNGNYLSTYIVPSNTIRVARLPDLCMMRNSGKNCEYSCTFDAKIGDFMCTCPRGMLLNDEDGRTCYNPPEPASEPEPSSEPEPSSEPEPSSEPEPASEPEPASEPAAEPTSEVTPEPVSKSEHSGKLVTETTSEPEPSSEPEPTSEPEPSSKLNSEPAAEPEPTSEPEPASEPKAEPEPSSEPEPASEPEPTSEPEPTSEPNAEPASEPEPSNKSATSTTSADHSAKLIVVSSTPEPEPTSEPQPEPSAEPEPAAEPTAEPEPSADSDSLSTSTEGKMELSSTTENSQLKVASGTSTQTVETPAPEPESSTTDVKSSQFENLQSMKSTTERETTAQTTPLLSHSSTTDDSQLPDFMFVDEDSMLKHSSTTENSALKVVSVTEQQVVSDTPAPVTETIVDDTPMPSTSSFFVPPKPTNAPDSKPTSTDGFQGRALPSNITAEPGSELYATSSPISLEQWRSSTSFATSTESLAREQGSDETNPFLPSIESSSARSNGASYAVTETVVEAETVAPILAGHNESPFLPDAENNASLVNILHLGLDRHEGDFEPQNPGFMDVLPLGKDSDRNEYKKQLNTHHTETTIYITTTIRAPVPVVTESLEELLSVASSRNIVEQTTNSGEEIVTSTERESMGEPTTVMDNVSSVKEEVASDRDATTTTSTTTSTTAKLTPETSTTEKMVENATSTLVAKEVSTEPMPITTISESEMITTTMEGAEEKTTMKLDTTEALRTVAESTTGSSSTSTSTSSSTTSSTSTSTSTSTSTSTTTSTTALPPVVTESLERITAIEKDLLKANDLVDDNDNILDNELRVIPLERQKEPGPTSTTTSPTATLAEGSTTEANSAADGSILIPTTTTGHFLDETTFHLIRSERSNGTSLIGSRFSDENEGQAPAQVVPTTERTEESKERMETLVLERAAAASMFTKCAVGQFECVNGTSIKDGSSCIQKSEQCDSVSHCSDNSDEQDCERLGCPGHFQCQDGVCLARLHVCDGIAHCHDGSDEQNCGAWQCNFDEISCNPATGNGPCLPALWKCDGLEQCANGFDESNCPDTCTNDEYFCAGQRKCIPEAWRCDGAIDCSDGEDERLCDCPLDSFKCNTGGCVSGAFVCDGHPQCPDQSDEWNCYQLDAEGGTLRVKRNSSEPLAVCGDGWNGKLADLVCAELGYAGARKILFTRVTNTTLVDSMYRVTEKDRLEFEPIHSMECNRGLEMYCEEYRCRQDSVKPFGVRINGGTPSQPNQLPALALAFSNNAAIKCTANIISPRWALASYTCIMGKTEFVNNRNNGDMTWKLFAGKEQFNSSLEESAFRSANSSYQIVDIKRVVPYPQSKYKQFMYTGDVALLELSSPLKLNEAVGSVCMAEAASISSEQRCVTAGWGSDLENTATATQYLKVLPVPTVPTEQCNSSMHYNGALPEDAVCAGYLNSNQTTCYNDEGAPLMCFNDDSDQWQLEGILSYHGNCGKRPHPAIYNSITSNISTWIRRTVGNGLMFERAAITTGSPLSGDESTTTATTFSSSFSSSSSPSSTVENSSSTATTTTVTPDLSNSSSTTMAPTTSSVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJE0</accession>
    <name>A0A084VJE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000778-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJE0"/>
    <dbReference type="STRING" id="74873.A0A084VJE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005357-RA">
        <property type="protein sequence ID" value="ASIC005357-PA"/>
        <property type="gene ID" value="ASIC005357"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005357"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005800"/>
    <dbReference type="OMA" id="QLWVIAK"/>
    <dbReference type="OrthoDB" id="28186at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="8">
        <location>
            <begin position="127"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="254"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005357-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="557" mass="64089" checksum="73DB3244E7F4246F" modified="2014-10-29" version="1">MATTPSSKASADDASKLGYSYVTPSGMCLRFRQSLAQFSDLFSEFNKYIAPAYHHDRCERSVHMRLYSMNKREFATVFLAFFACFGLGIFIGLAGPPITVMSKVSGSSLLPNVSGETGGGNGHLAKGPFVMRTPLMTTYSQQLWIIAKLLTANTDDEMVDKKFHINVQIEGLTAEHKPTMVYGARVGGLGMGVELKNRTRHLSCSYEECDEFTVLHFGFLDYAHYIVTVRFYGLEAFHQRYNIRTVQFYFKSYNPAFTQIEIWFRFIFVLFTFIITCWFAHTLRRYPMNDWSIEQKWISILLPLLLLFNNPIFPLIFIANSWFPGMIDALMQTTFLCGLLMFWLCVYHGLRQNERKFLSFYLPKLIVVLPIWLCAVMLGIWEKCDELNDPTYSHFEDSQNYNGLKVFVSIAGIMYLLYLGLLILKAYSELRSMPYFDMRLRILTLLMLIVLSITLIVTLQHFGFDTLEDNFIAQLYTSYKSSAQFMCFYGLLNFYLYAMAYVYSPSGPAVHEPIIAKDNPTFSMINDSDEEVMYGSDEESRRPLNSACRKGNDYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX8</accession>
    <name>A0A084VJX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005601</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013942">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524912">
        <property type="protein sequence ID" value="KFB38272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005601-RA">
        <property type="protein sequence ID" value="ASIC005601-PA"/>
        <property type="gene ID" value="ASIC005601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005601"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="240" mass="26705" checksum="EB5E80EBC92852BD" modified="2014-10-29" version="1">MVPVESTGAAISKMTAILKKAKVSKASMQDLRESLLKVVDIFKTEQESWRATREADQQRMREQFNSMNKRYVDSQNMLLDRMQLLETVASAGKTGAREEENRPTNPAILISAEAKEMVAKGLTDARNSAEFTAEIQQYVTAVRRARFSNAIIVELKDEADSAETVATALRRVVSKETTIRSLTPMEELVCKGIDVTKAEFVAKATPRPTDRRKGRQDDYFIRRIHEGLLQGANIAGGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLU5</accession>
    <name>A0A084VLU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP000440-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00006263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLU5"/>
    <dbReference type="STRING" id="74873.A0A084VLU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006263-RA">
        <property type="protein sequence ID" value="ASIC006263-PA"/>
        <property type="gene ID" value="ASIC006263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006263"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009043"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="440"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="659" mass="74448" checksum="4664CB956830F64A" modified="2014-10-29" version="1">MAPTLSKLLSNQNAVVGIAGCTVATCIILYGKQVHKNRKQRPEDEIQYFISDKKEKRSPKAHVNAVFFKQLRALLGIIIPKAWSVENGLLAVIALSLIARSVSDIWMIQNATAIESTIITMNKQQFRSSLVKYLSALPAIAVVNNVLKWSIGELKLRFRTNLSQYLYNEYLKGFTYYKMSNLDNRIANADQLLTTDIDKFCESVTDLYSNICKPLLDIVIYVYRLTTNLGGTTPGILLLYLFFSGVFLTNLRKPTGRLTVMEQKLEGEFRYVNSRLITNSEEIAFYRGNNREKLTILASFSKLVGHLRKFLEFRVGMGIIDNMVAKYIATVVGFYAVSLPFFEKNHPLLTGSQQSERLSRYYTFGRMLVKLAEAIGRLVLAGREMSRLAGFTSRMTELTVVLKDLNSGRYERTMVSNSAIADAGDIGPGRGLLKFQDNLIKFEHVPLVTPNGDVLVKDLTFEVKSGMNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPPAGKLFYIPQRPYMTLGSLRDQIIYPHTHQEMKRRGKTDADLLNYLDLVQLTYLQVREKGLDAIEDWIDVLSGGEKQRIAMARLFYHNPQFAILDECTSAVSVDVEGSMYEYCRQVGITLFTVSHRKSLWTHHDYYLKFDGHGAYEFAPIDGTQDQFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN51</accession>
    <name>A0A084VN51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006822</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006822-RA">
        <property type="protein sequence ID" value="ASIC006822-PA"/>
        <property type="gene ID" value="ASIC006822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006822"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013774"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="180" mass="19076" checksum="57737BC0B2A043CC" modified="2014-10-29" version="1">MGALCHVWKQGGERLQLTSAPFAGAGSAFSVSGGTGPTAAALAGRFPCLRCLAGVGNGATTDGTEAATSDGRRKRGGRCSHQPMPTTTTTMTTTMPDGNGRARDQPRGNGNGSGAMELMVMKTNEDSLMHQPGCSAMRTTELLRPEFFEVRLEPEERSRRRVKINAEEGSFQQLGDGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNA0</accession>
    <name>A0A084VNA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">G-protein coupled receptor 98</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006935</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006935-RA">
        <property type="protein sequence ID" value="ASIC006935-PA"/>
        <property type="gene ID" value="ASIC006935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006935"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8469" checksum="DAE2662B21C84879" modified="2014-10-29" version="1">MVNGHTPSSASVRYNLHSSLHTSGVGGKVRALHVSGAVDQNSGGARRSGSTVVEPHETGLRRCEPRSRPLCGNGKQRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNC2</accession>
    <name>A0A084VNC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP008056-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006959</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006959-RA">
        <property type="protein sequence ID" value="ASIC006959-PA"/>
        <property type="gene ID" value="ASIC006959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006959"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020927"/>
    <dbReference type="OrthoDB" id="10357271at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="7013" checksum="1EA8A7855A80CD5C" modified="2014-10-29" version="1">MTYIWRRMGLALLCLVLGNFVLFHDRERIVMAQLIEDETSLRGLDFIGDSPKGKIQWNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQP5</accession>
    <name>A0A084VQP5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 21">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 21">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">ZHAS_00007774</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="30 32" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="21">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="21">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Mitochondrion inner membrane</location>
            <topology evidence="1 21">Peripheral membrane protein</topology>
            <orientation evidence="1 21">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAPGEF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 21"/>
    <dbReference type="EMBL" id="ATLV01015283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015285">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015288">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015289">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VQP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007774-RA">
        <property type="protein sequence ID" value="ASIC007774-PA"/>
        <property type="gene ID" value="ASIC007774"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS006922"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010662"/>
    <dbReference type="OMA" id="CAYHREE"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04437">
        <property type="entry name" value="DEP_Epac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000002">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="19 21" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 20" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 21" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="24">
        <location>
            <begin position="46"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="25">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="24">
        <location>
            <begin position="352"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="27">
        <location>
            <begin position="485"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="26">
        <location>
            <begin position="660"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="23">
        <location>
            <begin position="767"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="28">
        <location>
            <begin position="1096"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="29">
        <location>
            <begin position="1233"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KFB40289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1346" mass="153027" checksum="FB60888562D7B3D0" modified="2014-10-29" version="1">MFVTIPRPCDRNLRDCELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRYWYAVLGGQLEVRYHAADTKDGKLSVTLCNLGVGATFGESILHDLPRDSTVVTKTTCELLRVEQQDFRLIFEKNKELMNDIITNCRLKNGFGQSMQTTSTVQTNVQQQPSPTKKQLSPDHPNPAAPITEIPSPAMSRMGWALRVLLVSDNTSCLKDRKVGGKFIRKCAPGTELVEWLLNLSPIVHTRTQAAGMWQALLEEGVLCHVAKEQPFKDKCFLYRFKSDEDGTAGGAPTSDDVNHANEHIREALPALLHRGPDATLRMILRKPSHERTQEELELVYEELLHIAALSHLSTSIKRELASIIVFEAHAHAGTVLFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKEGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLILERVAKQRGYSAFKYTVMSGTPQKMLEHLLETRLGGQAGPNDPFLDDFLLTHIVFMPTPLLIDELAANYHADADIDLRQASEEDQEYFLTSKRRVVQFIQRWVLAVRHAVFDDPLAVEFIEELATDVEAEPALQEEASIIHHVLTQLSRYQEDRQMNATQKWKLPPNGQPICLFSGNTHSKTVIRPDDDIIFRVYCADHTYCTLRFPMATTAEVIKACAADKLQIARLPEDLLLVEVKSSGERVVFKDNDVSVPTALSLNGRIFVSPKDHLDALTPLPEQEVPTEAPDVDFEALSTKDVAYHMTLFDWDLFWAVHEYELLYHTFGRHHFNKITSNLDVFIRRFNEIQYWVVTEIVSTTNMTKRMSLVKKFIKLAAFCKEYQNLNAFFAIVMGLSNTAVSRLSGTWDKLPSKFRKLFTEYEALIDPSRNHRAYRMSVGKLQPPVIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRAVRFCRSRHLVLDPPSPKNENEIRNYIRCFRTIDNQRVLNSMSQKFSCQHCEIILSKIMAVLVSDLKFLLACRGTFGQVCARDRWSWVNVMRRIRLAQAGTEPNVWPILSWLYFFNLPCENYHRNIHLAAANNAAAKKVKKFQIYRWNPDQPEQKPYNQTYEVDLSACGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDTDNLDKPTKIYPLPHMYVVKDLVPDMNNFYNQYRSIQPWLQRKNESTEKKGDAQYLQSVDDRAKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWIIDSRDESTAARLDKLKDPFSVYRCHTIMNCTRTCPKGLNPGKAIAEIKKLLSGIAKKDAPGLETAALHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS78</accession>
    <name>A0A084VS78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008345</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525037">
        <property type="protein sequence ID" value="KFB40822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008345-RA">
        <property type="protein sequence ID" value="ASIC008345-PA"/>
        <property type="gene ID" value="ASIC008345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008345"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008345-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7623" checksum="C7B7EBCC116EBE8C" modified="2014-10-29" version="1">MTHAVNAPFDADGEVMRHPFSPCEDTPVVPARNSRRKAESLTFAAGVTVKVNQCVIISRTEPASEAWLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSE1</accession>
    <name>A0A084VSE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP002411-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008413</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015924">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008413-RA">
        <property type="protein sequence ID" value="ASIC008413-PA"/>
        <property type="gene ID" value="ASIC008413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008413"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023101"/>
    <dbReference type="OMA" id="IKSDMYR"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01817">
        <property type="entry name" value="RBD1_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17067">
        <property type="entry name" value="RBD2_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="734"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1423"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1621"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1427"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1655"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1726"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1765"/>
            <end position="1801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1878" mass="199012" checksum="21193C36A0CD27B6" modified="2014-10-29" version="1">MANNSESADGECVPTKSSEITIVMRTIMSSGAGNAKNELVQKATIGNDRDQSRECSTGHGCPAGSNRIEVTTSVRTVLECPAVGKDGGQPSSAAAACVEAAAVASILQPVLSKNFIALLKSANDSSFENVLEFKSLLAGAGGGSGGGKDRCRSCEQHSKHGLSSDDSEVAAIDEQATMAAVVKKAKTDAEAVASGDPGAKRNAFRDRLGSTSTPIKIRIEGGEQRPDGMGEDYRLNLLTPPADASFIDSDFESMEQDQYDTCSSKGSSRMGGQDHQELTAQQRMLEELACLEVPVTKPSPPSPVRKAQDPWGSCSTTSRKSSSSTKAFFEEALRTPLAIRKHFQKRRNSELPKQPSHGNLLNFFTAKKKSNSLEGGLKSPRAKRSLTCGTATTTTSENSSENGSRCVSPALTEENLRRLSVAFVRRESDALNRTLVWGENYDYSFECEPSHSDVDEEDEHDGQQDDGDGGDGSPPVPLTNTISSCISTERRVSTKLVHFELSSPDSSYELQPPIVPSFKIDPPGGGACSTSSGVAGLIIGAAAYATATTTASFLKRSASEPLHCKLRSHSCTPLTSDIGESDEEDSDPVLSSREEAPIMCKALVPVRPFTSVHQASVRSLDKIGGKQINHSASPFRRWGQSSLRSRSTEHRTPNGSARRPSSLAASESDVYTKSIDDDYSSTKSGYNPYGGGSCGDVLAVDSGMAMHGTGTGTGGKSTGTGTGGPTGVASWGTSFEKLLEDAAGLHTFSEFLKKEFSAENIYFWTACERYRQLTEREDRAREAQAIFARHLESGCSDPVNVDSIARNIALEHLPQAETTLFAAAQKQIFNLMKFDSYQRFIKSDLYRVCQEAEAKGHPLPYPGDQLDPMLRTNFTMVPGGSAGASGGVTKLKKSLSNAEDRRRKSLLPWHRKTRCKSKDRGDSDASKKDGGKGSANGGNGTANGAAGAAAGGSSSSNTLKLLSTNSTSDIHSSRSSLASFDAAIGGKSYDPDDTRTTLCRVILSNGATTVVQTRSNETIKELVERLLEKRGIVYNAYEAFLASSSKPLDLDGPSVSLAGKEVNIDQRVVFKLNLPNRKMISVKSKATKPLADVLRPILHKYNYELDQMKVTDASDVGLDMTQPVTTVDGLCLYIRSAADHSTATTATTIHPELGRPLAGARPVINTATHQQIVHHFQQQQQQLLNSQSSASQQHQFAVPSSNLPSYTLATNGKSRSFFRNSMNTATAPSTCNNNNNSLNVNHNHLRTKEQQGQHEPQQFKEPEQPLPPASNAVTAHNRGQQPDLNTLDEITNKVFNELMNGKTASNGATGKGPPDVDCASDTSSSRRDRFRRRGSNAPSESGRGAKSKKCSTGGSEDGGESVTNGGTKKPIIAKLKAGVKLQMPTRSQNDELLEGLKRAQRSRLEDQRGTEINFELPDFLKDKENFTSSTGTSGAGSAANSQVPSGVPAPQGGPTSKLTRSKPARRSEATTPTAEFVGGSLQQINKPQPAPRLSITGGQTRGSQVGGPGSPVHAAVSDSQLNLSTQCNASPLPLDDPFRVRGGESQSENSYADTTLVFTHATPVQGQSPVAATPRTIIHHRHHQDDGRSDDQSSDSSAAEDPPCDDIHTGCCDHPYDTSPDCSPPPAHGGQLHPHHYHHATPAGAPGGTNPTHYPPHHHHHHNSLLHHAHHHPHGQHYHHHHHPGTRYQATNGGGIGSTNATVTPLALALDSGQPAPAGGDQNQKGPPPLPPKPKILPMKPSNWGHPGGVTAPYSMPNGDGGSHTGTSGSTSSSGTSSTSGSTANSSTSSSSSSSSTTTTTNHQHHSVSANEGVGGGTAVVGSNGILSSNHNELANVVREGNRRASGGIAAESGSSVISSSVAQARSVYFDQGSSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT62</accession>
    <name>A0A084VT62_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525072">
        <property type="protein sequence ID" value="KFB41156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT62"/>
    <dbReference type="STRING" id="74873.A0A084VT62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008722-RA">
        <property type="protein sequence ID" value="ASIC008722-PA"/>
        <property type="gene ID" value="ASIC008722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008722"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002531"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="220" mass="24907" checksum="FB450E88C3316CED" modified="2014-10-29" version="1">MIRTENCVYIDNVLPTTTRQEVWQHFKAFGPIRSIRMELPDGTLVLTDAEYGELRSVNCQIRFRRRAEALAAAKGLKRSIFKDRLLSVQMAYQKYCNPEELSNNALRIFFQPFGDIVALDQIPHQRVGYVCFKPPVPVDIVKRIHQLPAFRNRRIMVEKLELPGIPKDGAKAIKLLGNGKGSGGRAGDGNGTGNSSTSNQQQQPKHGRYYGQQDGIEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT89</accession>
    <name>A0A084VT89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00008745</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016275">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT89"/>
    <dbReference type="STRING" id="74873.A0A084VT89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008745-RA">
        <property type="protein sequence ID" value="ASIC008745-PA"/>
        <property type="gene ID" value="ASIC008745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022672"/>
    <dbReference type="OMA" id="DISHEPK"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="11">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="361" mass="40763" checksum="142F9DC043E9E38C" modified="2014-10-29" version="1">MPSEYEFSLEKLTFGDQLGEGAFGVVRKAVARDIYVHEPSTTVAVKTLKPQCSDYVVDDFISELKTMVSIGQHLNIVNLLGAVTTNRLKRNIIIIFEYCQHGSLDVFLTTNRSRFVDCSSMLRDLDNWRTHNPEGQREETPVGEIQFNTTSLICWAAQVATGMTYLASKNVLHGDLAARNVLLCDKNVVKISDFGLSRTLYRGIYKKQSDSPVPIKWIAVECFKELVFSTKTDVWAFGVFLWELFSLGATPYPGVTNGTEMYNLLETGHRMPKPNTCSREMYDIMIRCWYVCARKRPDFSELAYIINEMLPDELKNYYIALNGPYVKKNALQGIISSSVQPIVPNASADATVPYPAEHFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTA9</accession>
    <name>A0A084VTA9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002760-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008767</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTA9"/>
    <dbReference type="STRING" id="74873.A0A084VTA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008767-RA">
        <property type="protein sequence ID" value="ASIC008767-PA"/>
        <property type="gene ID" value="ASIC008767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014940"/>
    <dbReference type="OMA" id="WITENDC"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000020">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049542">
        <property type="entry name" value="TopBP1-like_BRCT0"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21298">
        <property type="entry name" value="TopBP1_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="207"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="406"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="603" mass="66550" checksum="ABA7FC749239AB42" modified="2014-10-29" version="1">MQSQSSVMEQQLEKLYFVLRTEYTTEEDASEDMKSAYSNARDHSEKLTEWIAEASCLKLDEERMTKKHVFVFEKFSGAAFERVKKFPSTIIGPRCLISCFMAIETIPLGVHPVYTTAMRNLTVCSSGLKAKEKAAISQLVFYMGGYFLDVLNLTCTHLVSSTVESVKYEKAAEIKLPIMHPDWVHRVWEESQQRYVHATDECYMKRHRLPVFHALTITSTGLTAAKKNEIKALIEANGGVYTGAFKSEVTNILILEKSSIGSAKYQGAVKSKKECLSPEWIVDSVASGYALPIRQYEVKSMKASTPTKNGDGTTTTTATSTGGGDATPSIGGRISGGEFNPDCTQLSDISHANFSARNVTINESIMPCGSSVDGFPVASTMSGGARPCSQRYREFLSRMTVQQAKKAGPLLDGCNVFLSGFTAEEKEKLNKILNALGAVRYDEISATVSHVIIGEQNVSDLAQLRDSAAHLLTLEWLAKSMELHQLAPEDEYVFRPSGRGLPERAPEPPSPSSKKNLQRMNSSVFKRPEVPKLKLDMETNVPAKVPADARPSQEDSIMLQYMEKNLAERLPQTTGHRACPNVIRKATATTRTECNVHNGERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU11</accession>
    <name>A0A084VU11_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Epithelial membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009053</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016625">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525098">
        <property type="protein sequence ID" value="KFB41455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009053-RA">
        <property type="protein sequence ID" value="ASIC009053-PA"/>
        <property type="gene ID" value="ASIC009053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009053"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022736"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7109" checksum="25FB4B54189DDC30" modified="2014-10-29" version="1">MSLVATAAALMLPSASNVVRTVVEEKSSVGGGSNPSGGDCRVTDDRTNEDTGGDRTEGKEKLVEVEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWM2</accession>
    <name>A0A084VWM2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="13">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00010057</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 13">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWM2"/>
    <dbReference type="STRING" id="74873.A0A084VWM2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010057-RA">
        <property type="protein sequence ID" value="ASIC010057-PA"/>
        <property type="gene ID" value="ASIC010057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010057"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001005"/>
    <dbReference type="OMA" id="CVQLSCV"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010057-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="735" mass="81220" checksum="D277ADFFB49630CE" modified="2014-10-29" version="1">MSVKLCCYFLFYSQSIPPILVVILIGIAGLQAEELKNEATPAQDIRLLLEDVKSHLNRFNSHYLINLEQRIVSVLTTMTSLDSNVKTLQEKSQIWDVFQHHIGAWSEHIKSVDSKLDILKNADILLKRIEHLVLDVDRKIEKRNNQQCTKNPSPALPDHQSKVKSNNTLEESLDISTQVDMGSGSDESTGDDNVQPQIILLKEGTDTSQGKPQLVSNINACQTIVDAVRTTLGPRGMDKLIVDSKGKATISNDGATIMKLLDIVHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQLKPFVEEGVHPRIIIKAVRKALNLCVAQINELAFKIEKHDSEKHRALLEKCAATALNSKLIHQQKEFFSKMVVDTVTTLDVLLPLNMIGIKKVTGGALEDSLLIEGVAFKKTFAYAGFEMQPKSYDNVKIALLNIELELKAERDNAEVRVDNVSEYQKVVDAEWQILYDKLAKIHQSGAQVVLSKLPIGDVATQYFADRDMFCAGRVPDEDLKRTQKACGGAVMTTVQDISEKVLGNCAHFEERQIGSERFNLFQGCPNAKTCTIILRGGAEQFLEETERSLHDAIMIVRRTIRNDSVVAGGGAIEMELSKMLRNYSRTIAGKEQLLIGAMAKALEVIPRQLCDNAGFDATNILNKLRQKHAQGCQWYGVDIMKEHIADNFEAFVWEPSVIKINALTAACEATCMILSVDETIKSPQSGGGEAPQPPMGRGMGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWW6</accession>
    <name>A0A084VWW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525186">
        <property type="protein sequence ID" value="KFB42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010167-RA">
        <property type="protein sequence ID" value="ASIC010167-PA"/>
        <property type="gene ID" value="ASIC010167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010167"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012840"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010167-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="508" mass="56392" checksum="3D6F04D958B20559" modified="2014-10-29" version="1">MEPEKRMPSKGPSSLVSWEERASTTAAAALNGVTPQRVRTDPSSPPSRSTTLSAITAEEKAENPHAATPVGMLGVWATQDIRPKPRPRNLGGADRIRREKEIRIRMAILDLDLQLLKLETEKEEEEYLEEGQEDLSETLGCGTEAPHGEEAHASQPVVLFATTGCPPAGSGEDVPDAPRDDMAAFLEWRRAIDAKVRASAMAESINAPAMAHKLNNNATEKGHASGMAHSLDTLASHGNTATTSTLYIKFTAPTGHTAHTATHYGPTTQTIHASNIGHTALSTHTTPSSQTAATKHSSFLGNTSPRNGTDAYTFRPLSSVPHMKDEEKFDWATSARLREVTVSIQRRFRANRLMERQMEVYSRQKCAAVVIQRWFRGYRAMIEWRLQQRFRAHAAIVLELLPDFCGAILSAPFRERRYNESSTNYKGPAPESIDRRQHERDAVRLQSWWPGGNHRKRFLALLLSELFGRTPMMAENSLKDALRSSWLSGRMHSVACCFFTSVSVLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWZ3</accession>
    <name>A0A084VWZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSF_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010192</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017810">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525192">
        <property type="protein sequence ID" value="KFB42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010192-RA">
        <property type="protein sequence ID" value="ASIC010192-PA"/>
        <property type="gene ID" value="ASIC010192"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010192"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011153"/>
    <dbReference type="OrthoDB" id="6418155at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010192-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="283" mass="32415" checksum="0FF21B548D30DFEE" modified="2014-10-29" version="1">MHFVQKLWFALNKHSINCVYWNEDKTATIIDLDKFDASKLEEILNCNTAEDFLCMLKHYGFERQPLGKSETMNSSHAIYRHPVFEGSNEQLIDCWIKDSYNQLDADYSASARPCLRPDSLANEFRPRDFDDKFEKVKASITAEMRLLDAYIRKEYLNNGSNGENTLTIPLKYYDEATQANEMTTSKDPRGIDGYYGTNDFSELQTYFGNMLVEGEDAVNEKIDDVINPQEFDENLQPVANGATTTIKSEPMDTTVENYLCINEETPNIITDSVLSCIGQLDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ57</accession>
    <name>A0A084VZ57_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Arabinose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011031-RA">
        <property type="protein sequence ID" value="ASIC011031-PA"/>
        <property type="gene ID" value="ASIC011031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011031"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011031-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="9067" checksum="6EBDF3ADA9600C89" modified="2014-10-29" version="1">MGSAQQRGNVQTIATPPSQERSTFFSRPDDVVLVGSPPRRNLFLGRLIHLRLCAGPLQHVVLFYLSMVRISFPGQSEQACGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZR2</accession>
    <name>A0A084VZR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004771-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011307</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525256">
        <property type="protein sequence ID" value="KFB43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011307-RA">
        <property type="protein sequence ID" value="ASIC011307-PA"/>
        <property type="gene ID" value="ASIC011307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011307"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784326" evidence="2">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011307-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="20871" checksum="EABAE1A231415B3F" modified="2014-10-29" version="1">MALRVSFAILIVICAAVVPVVAETETSQGFFTQLWDSIFGTNKPANNNETVPSETKSTADGANTTELSTTSSSSVKEKEISVTETTKSSSTIVFGQEANSTEGGHVTSSTTPKTNETERTSNDNSLNSASTSTAGNLPVTEVTMTTVYNSSVTEVPQNTDATGSLLTTSDLISTTVLGTENESNATTTTESPKQPPKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W063</accession>
    <name>A0A084W063_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001250-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W063"/>
    <dbReference type="STRING" id="74873.A0A084W063"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011545-RA">
        <property type="protein sequence ID" value="ASIC011545-PA"/>
        <property type="gene ID" value="ASIC011545"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011545"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009279"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011545-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9893" checksum="23A367154631727B" modified="2014-10-29" version="1">MCMPAGHRDYTIEYDVSLLLAGADFVGQFIAPVLLPPATSGFAPGTMANATGWGLQTVPNSLPIQLQWVSLPLISNEECRTSWPSDWITEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W097</accession>
    <name>A0A084W097_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001106-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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                <consortium name="EnsemblMetazoa"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0I8</accession>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1144" mass="131292" checksum="D15F5104FDCA7131" modified="2014-10-29" version="1">MSNLSSDNESSFATESETENEYFWNEETSRNHECYTTEVEDIIRQNVDVTTANAIALNHHYQAKLRQLRTQIETLLQQCQTRLKDVDTLVDNMRYNRKESIPYKVRIPGYICGQPFFKDHELYPGPHNADYLYRKNVKKEFFPLDMFENTETHWTPKDKTKMKDGILKQVVEFLRREGELRAKMCGSASQAEQIRKDIISYRTLSLEALWPKLQSYDDGKFGGQCFKVDWLVISNVSVSGRHTAAACEGMWNQYLKPGLKKGLWKQEEECLLMTAVRQHNYQDWCSIAQSVSNRSEYQCFVHFRTCFSQQAHIEKKPWTPDEDALLLRMVQENRIGNNVIWNKVVEKMPNRNKVQVYHRYKYTLTRPLKGAKFTPVEDCVITAYVQQYGDDFKYFPEHLLPGRTMKQIYARYNNTLRYVDKHTGWTLDEDKRLMSYIGEHLTEEGPEKISWSDCSRYLVNHSRASCRTRYYTIEKFLEKYPNATLEDVPRRAGKKLSTDITHENWMKTIVDIRNTTSEINNSYDDGKLCETFKTVGEWALYDQMKFCFRYQFGHKLAVESTRKSVHTRTKLLLHRLGGFHQEGVISSGTYFLNEEDQSTMTAVINSPLDWSKPQTDKKENDGSNEPVFCRIPPNYNTVLGLRGLCLNFHYESKTHSSVSRKLSRFKPTKDAEYNTAVELFIERFKAIFHWSMLLVKLNIDEIVFVTGEEDQHAEAITISDIVDEKPCSSGHPLRASHVDCLERNFVEKTRRATRKKHTSIGKVMQVSENKNSPNQSTDIAVSLYHDNNCDMPIVKNITIINPWDLPVSCDQTLTPGDNHSDFNHPPTTIQPTGVQKTYKKSRQTNVQKPTEVLKKIRKSNTRSKRKTAIKAETADDQLSHGITCVVEELQNAEQHSAPKFVEVPEIVSVYSLVTVPASVALLTEEPTAESYNIQEVSDVANVTNSALKLNSDELTFYEKLNDGSAFKSVLSAKPVETHSRTMVLSVLDDGVDRLQSGENDSADPDPGKAEVHNQIRLALGEQQGTPRKELSTRNECSKDGFEINPLERRTIEDGENDEQKSFVNELIITNRSGEEFDYNCLIVEERTEVNEHNYANADPGVNVIQEINLTPTAGDTIPEQNIVEQTKATAGSRLGPASNESYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1Z8</accession>
    <name>A0A084W1Z8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009636-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012136</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1Z8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012136-RA">
        <property type="protein sequence ID" value="ASIC012136-PA"/>
        <property type="gene ID" value="ASIC012136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012136"/>
    <dbReference type="OMA" id="IGVIGPY"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784080" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012136-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="8798" checksum="0FBCE8CF2B931E38" modified="2014-10-29" version="1">MKNLVVVGFLLVLIAVLSVHSNPVPQFGIGIGVIGPYRPFGYGGYGGYGGYGGYGGYGGYGGYGGYGGYGGYYLRRPIVTPILYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W271</accession>
    <name>A0A084W271_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001334-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Neugrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012186</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019525">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525273">
        <property type="protein sequence ID" value="KFB44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W271"/>
    <dbReference type="STRING" id="74873.A0A084W271"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012186-RA">
        <property type="protein sequence ID" value="ASIC012186-PA"/>
        <property type="gene ID" value="ASIC012186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012186"/>
    <dbReference type="OMA" id="FMDVQKT"/>
    <dbReference type="OrthoDB" id="6415470at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="383" mass="45331" checksum="EE84FE8673948B4C" modified="2014-10-29" version="1">MLRNIFKTVYSKQKFLCRYYVRKARNPGIDRRAVLLPEDAKAEEYENLDDIEPDFHQVHKSHKQFEAEQAQYRDRLQTWIVGNKYFKTKQLNFLTWSEKEQIRYLHAFDPEEWSIDKLTESFPADRYTIAKIVKTKWQPKDNKRMERHDAAVKENWQMFRSGRIQNIDPGFAQHLNKFVQRNVENGGELKMKVASKRLYEIRPLPEGEFSAIVTSCKKYQTREQLNDSQQELLIDGSEELESKELLISPNAPKQDTFLMGEIKHTQHITISEMKKREGTETNRNVKFVDDHAQLDLGKEIVDRLVNVNEQNLAPAVADSSYDLRDKTKEDIKEFIRIPKKLYKKGATYQLDDCFYDDDGEFLYRVPGKEVQKKLNKSFFLNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W345</accession>
    <name>A0A084W345_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">4-hydroxybenzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012524</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525279">
        <property type="protein sequence ID" value="KFB44639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W345"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012524-RA">
        <property type="protein sequence ID" value="ASIC012524-PA"/>
        <property type="gene ID" value="ASIC012524"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012524"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10293" checksum="B2EB49D00F1C8DD3" modified="2014-10-29" version="1">MSTACWLPVACAPREATAWKWLQFRRLRARQGCAPKWFAQLGPGCKYDGAQDSRLIVLSRERRTSGKEIEDDVGNATPEGNRRDRGRENAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3N1</accession>
    <name>A0A084W3N1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP011197-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012735</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020065">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3N1"/>
    <dbReference type="STRING" id="74873.A0A084W3N1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012735-RA">
        <property type="protein sequence ID" value="ASIC012735-PA"/>
        <property type="gene ID" value="ASIC012735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012735"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007818"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="36211" checksum="CEFB7E00EB3AD332" modified="2014-10-29" version="1">MAKLDFLHTRQVQMDYGFKERDEELNEKLLNLENVFGWAGHNLTAIQELSRKILAQQIACANHDQMRKDIIELSVKQVDVVNAKLFANVSLPASKYNENGKNIQNRYIKSCMEAPVNASGGYWLQVNPTDRPLEVFCEQRTFGSGWLVIQNRYDGSLDFNRNWTDYRNGFGNVYKEHWIGLEKIYPLTSKRPHELIVEFKEYSTVCHIPSNTASYFTINSTEESGGGYGFGEMMAKLSQVQNKLHEIENGLKERDEVVLEKLTNLENSLEELNRHHQDEQKTAGVNQSQVDDTTTTEQILERTKEWVNGSSVDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W494</accession>
    <name>A0A084W494_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005670-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012980</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W494"/>
    <dbReference type="STRING" id="74873.A0A084W494"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012980-RA">
        <property type="protein sequence ID" value="ASIC012980-PA"/>
        <property type="gene ID" value="ASIC012980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012980"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015308"/>
    <dbReference type="OMA" id="HENWMPS"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784186" evidence="7">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="55"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="300" mass="32020" checksum="E4B09C4277BFF799" modified="2014-10-29" version="1">MKSFALLVGLLAVASAEWIDIDWSKVRPIEDFDHYWARLPAELQVYRHMRPSARIVNGQEATPGQFPYQIALLSEFLTGTGLCGGSVLTNNYILTAAHCVVSGATTLATGGTAIIGAHNRNVQEPSQQRIRFSTAGIVRHPQYTPTNIRNDIAVVRLNSPITFNARVQPARLPARSDTRQFGGVMGTVSGFGRTSDATQGTSAVVRFTTNPVMTNADCIARWNTVLIQPQNVCLSGEGGRSSCNGDSGGPLAVQDGGSLQIGIVSFGSAAGCSVGMPSVYARVSFFLGWIEANSDYVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M8</accession>
    <name>A0A084W4M8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013131</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013131-RA">
        <property type="protein sequence ID" value="ASIC013131-PA"/>
        <property type="gene ID" value="ASIC013131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013131"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013131-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11864" checksum="90DFEC2CF33E5352" modified="2014-10-29" version="1">MQVGYQRQVSEYESIPRIIKLCSTPGRPAIPNIECRSVSASSTYRPDRPKLNALTLEPTKHSPANCRALADSVLAFCLSDFCEPTPLAQPDAGPRVEFEGGIYDAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W537</accession>
    <name>A0A084W537_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">RING finger and transmembrane domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013279</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W537"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013279-RA">
        <property type="protein sequence ID" value="ASIC013279-PA"/>
        <property type="gene ID" value="ASIC013279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013279"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013279-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9578" checksum="3DBA9CE6C9E29035" modified="2014-10-29" version="1">MNLATNSSGALSFLGKKRSNRPKTSFRSRPGYHSRTHTATHCHTAGAPRRPSAPLSRSHDGSKILPLVPIPSQFAQGEPSSSRNRLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5G0</accession>
    <name>A0A084W5G0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013391</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020620">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5G0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013391-RA">
        <property type="protein sequence ID" value="ASIC013391-PA"/>
        <property type="gene ID" value="ASIC013391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013391"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="12866" checksum="16CD3BBBA1EDA6AD" modified="2014-10-29" version="1">MVLHWTVQIGSVLHDSHVLDVLKPVARTTDNALARSGPGHFNQKHTGATDRTLFPTRGGLAITMVWTGGTPEGEAKHDSSLAPGCDKNQSGCVRVQTTNNPPVLERCGMGTCYLFLLALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5P4</accession>
    <name>A0A084W5P4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Voltage-dependent calcium channel type D subunit alpha-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013485</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5P4"/>
    <dbReference type="STRING" id="74873.A0A084W5P4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013485-RA">
        <property type="protein sequence ID" value="ASIC013485-PA"/>
        <property type="gene ID" value="ASIC013485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013485"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002275"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="9683" checksum="12A3BE963F4E8AD8" modified="2014-10-29" version="1">MNENPPKPMATAATTGVSAAGATASPPPAPPAAASGVEDGAAADGTGANNQPKRTPRRPGKVQPERPKRVFYCLTDKNPLRVVCTKVVEWKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5W7</accession>
    <name>A0A084W5W7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008366-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00013602</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5W7"/>
    <dbReference type="STRING" id="74873.A0A084W5W7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013602-RA">
        <property type="protein sequence ID" value="ASIC013602-PA"/>
        <property type="gene ID" value="ASIC013602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013602"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001802"/>
    <dbReference type="OMA" id="KYMETGY"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="4">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="5">
        <location>
            <begin position="658"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="751" mass="83751" checksum="14091954DD26D12C" modified="2014-10-29" version="1">MMYECAMAASGVPMFGGAAPRAMKMARRGGPVAESTSEEPPVRSNFCETWIWESFSVGNEARSIRKSIPDTITSWVITGFSLNKTHGLALTDEPSKITVFLPFFLSIDLPYSVKLGETVRIPVVVFNYMQEDHGADLVFFNNSDEFEFVADDATEAKVFEDHHRSIRSTIARDSGKTFSFLVKPKKVGHITLKLTAKCAMAGDAIERLLLVEPEGRRQFINKAMLIDLRTEKEMQQNFLVEIPDDAVPDSSKVEVSVIGDVLGSSIENLDSLIRMPFGCGEQNMLNFVPCIVVLDYLSACGRLSVEIEAKAKKYMEVGYQRELTYRHADGSFSAFGQSDEKGSTWLTAFVAKSFQQAAKYVTIDMTIIDQAFEWLGKVQAKDGSFPEVGTVCHKDMQGGAGSGIALTAYTLGAFLEIVKNENFDQKYAKTVETALDYIKSNIKKQDDIYAYALAGYVLEKADSVLKREVSSDPAIPKSANIDEVIDKAYHDMKIEVFNHLESKAKIKGDRKWWSKSTDTPANNKPRCWWNRPCSVDVEMSAYALMATLEAEPNGLEGLPIMKWLVKLSNDEEKSMAVNRDNVLVLQKYELPNATRELEMSATGSGCALFQLSYKYNIKDIDNSPRFTLNPEAKRGASACSIELKISARFIPNADQTVSNMAVMEVDMPSGCVAEIDKTEFMQINKNVKKVETKRSETAVVLYFDNMDETVVTVQIAAFQKHEITNPKPANVTIYDYYDNTRCASAFYEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6C0</accession>
    <name>A0A084W6C0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006866-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6C0"/>
    <dbReference type="STRING" id="74873.A0A084W6C0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013738-RA">
        <property type="protein sequence ID" value="ASIC013738-PA"/>
        <property type="gene ID" value="ASIC013738"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013738"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022218"/>
    <dbReference type="OMA" id="YSNINQH"/>
    <dbReference type="OrthoDB" id="6382835at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013738-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="18895" checksum="9FCE6EBEB7C6791C" modified="2014-10-29" version="1">MLVATGSAYVTGNGYKILTKHSSHYFGNGANAIDSYQPSGIGSGYSEAGLIGYKSSQDSQAYPENGYDASDYYTYPKYKYDYGVQDAHTGDHKSQWEIRDGDVVKGGYTLYDADGTKRVVEYSSDKHHGFQAHVKRVGHAHHPQVYKTEHGISGGGYEEAAGYSYSNINQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6D2</accession>
    <name>A0A084W6D2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013751</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6D2"/>
    <dbReference type="STRING" id="74873.A0A084W6D2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013751-RA">
        <property type="protein sequence ID" value="ASIC013751-PA"/>
        <property type="gene ID" value="ASIC013751"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013751"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018618"/>
    <dbReference type="OMA" id="HERPIEN"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784271" description="Ionotropic receptor" evidence="9">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013751-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="51201" checksum="EB4324971B5DA023" modified="2014-10-29" version="1">MSAFALMKILGILNFIVVQVQLETFDKLNVWTKNQFTNQEHYFLSDHRPVEHFFPDKLHDLNGNMFSFYGEWDFPYVIVVDDKVFGVVPKFIDIIIRQRCNGTTFYTQDPKFTFVTDSRYNILQFRLSFAHTLFFREQSGVFLVCPVRTERDFLQPLLKPFSMGIWIVLGALFVTCRVLQFLFPTTYRYDLVGITFFGGGGTEYEHPFKFRIVTFTLIVLLFFLSEAYNTKLISLMTFSKFYKQPETLEEFTQSNYRILASRYAAETYSDLRPKFLSLSETRREERRLGWRKNEIYCSTVDQGIALPIHVLRLKDYAVPLYVIPEPIAVDRSLVQFHQYSPFYDMFHMYFDRFNDAGLWMNLVNSIVYTLGKSKRDRQREEQFQEVIFYFDDLTCIWLLVIAGWLVSGITFFGELISWKIQNKLRVGNFFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6F1</accession>
    <name>A0A084W6F1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP006836-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00013772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6F1"/>
    <dbReference type="STRING" id="74873.A0A084W6F1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013772-RA">
        <property type="protein sequence ID" value="ASIC013772-PA"/>
        <property type="gene ID" value="ASIC013772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013772"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007040"/>
    <dbReference type="OMA" id="DQKSHWE"/>
    <dbReference type="OrthoDB" id="6427684at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784541" evidence="3">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB45795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013772-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="17564" checksum="FC9E93E813647C48" modified="2014-10-29" version="1">MKQFFLISSLLIVAVLATEEHVEVAEASVEHEQVVPEVAQDIEHHGYVDDYYAYPKYKFEYGVKDPHTGDQKSHWEERDGDVVKGVYSLYEPDGTERVVVYRADKHNGFEAHVKHVSHEVHHPAQLHGHQEHSYLGEHHGEHGYSYSNQHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7Q4</accession>
    <name>A0A084W7Q4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014137</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01021272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7Q4"/>
    <dbReference type="STRING" id="74873.A0A084W7Q4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014137-RA">
        <property type="protein sequence ID" value="ASIC014137-PA"/>
        <property type="gene ID" value="ASIC014137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014137"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022385"/>
    <dbReference type="OMA" id="PIWLPLA"/>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046068">
        <property type="term" value="P:cGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000031">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000032">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="608"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="696"/>
            <end position="700"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="850"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="850"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="903"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014137-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126071" checksum="502135DCC2BAF058" modified="2014-10-29" version="1">MPTEQGGTVGLDTTLGSRSGVPLPLQLAPHSNHHSNNHHHQHHHHFHHHPQAGQQGHHSHHYAGGGGAGGSGGSGCGAGATGYDAEFARMESWLDENPEFVQDYFIRKATRHMVDGWLVSHATPVTSGGSGNSNSNSGNSTSVDSPTHGPPNQPSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSISPQNESANSGMVQCCPNGVTYCGANLRPLRLSRNELKQLDERELIFELVKDICNDLDVRSLCHKILQNVSILLNADRGSLFLVQGKSTCGGDNTKKCLVSKLFDVCSNSTLAEMEQQDEVKVAWGTGIAGHVAESGEPVNIPDAYQDDRFNREIDVQTGYRTKALLCMPIKDASGDVVGVAQVINKQGDQCFTTADEKIFSSYLQFCGIGLRNAQLYEKSQLEVKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEASKGSFSRVFDFEANDLSGEDGDARTSPFESRFPINVGITGYVATTGETVNICNAYEDDRFDPSVDEGLNFRHKTILCMAIKNSLSQIIGVIQLINKFDDLTFTKNDENFVEAFAIFCGMGIHNTHMYEKAIIAMAKQSVTLEVLSYHASATIDDAYRLRQLKVPSSAFFKLHDFKFDDLSLDDDHTLKACIRMFLDLDLVERFHIEYEVLCRWLLSVKKNYRNVTYHNWRHAFNVTQMMFAILTSTQWWKIFGEIECLALIIACLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMIINSPGNQILSNMSSEDYSRVIRVLEDAILSTDLAVYFRKRGAFLSLIEPNRGEMSAWQAEEPRSLLRAMSMTVCDLAAITKPWEIEKRVADLVSSEFFEQGDMERQELNITPIDIMNREKEDQLPMMQVGFIDSICIPIYEAFASMSEKLNPLIEGVLENKRHWLELAHSAKEAYANNNNTSENNNNNHLKHHHHHHNNHCTEHGEQANSKQQPEEAGGDGPTPKRNSLGSPTSNGTTSKLSPPLDCTDNGHHHSIDIGGHDPTSTTVCCTANIKEKIVGRVGVDLASSPPYGEKLSYLVGQKGNGWVQGDKVRLIRLSSSDGKTSELLLLTDDQQQPEQRLRQPKSPQQRDETELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7T9</accession>
    <name>A0A084W7T9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014269</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7T9"/>
    <dbReference type="STRING" id="74873.A0A084W7T9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014269-RA">
        <property type="protein sequence ID" value="ASIC014269-PA"/>
        <property type="gene ID" value="ASIC014269"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014269"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017317"/>
    <dbReference type="OMA" id="YMAAWSW"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014269-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="513" mass="56511" checksum="58838B6DE1372A57" modified="2014-10-29" version="1">MTRKDVNSVPPEAETATVTPGNAEGGDKVVLKRKITLINGVGIIVGTIIGSGIFISPTGVFVFTKSVGSSLVIWTLSGILSTLGALCYAELGTCITRSGGDYAYLLVAFGPLVGFLRLWMALLIIRPTTQAIVALTFAQYAVRPFFEDCEAPEMAVRLLAAVCLCFLTAINCISTKWAMKIQDVFTIAKLTALISIILAGMYFMATETLDNFHNPWEGDYALSSLAYAFYSGLFAFGGWNYLNFVTEELENPYKNLPRAIWIAMPMVTGIYVFVNMAYFAVVSRQEMLASIAVAVSFGNRMFGSVSWLIPIFVALSTFGGVNGILFTSARLFSTGAQEGHLPAWFSLVHVDRQTPIPALIFTCITSIIMLLSANVFVLINYFSQILWLSVAASIAGLLWLRISKPNMHRPIRVNLALPIIFLICCLGLVLLPSFSEPFNLLVGLAITLSGVPIYYVCIVWRSNKQSKNFCMQWIERGCQILFNAAFVDCHHDRKRDPEFSEMQTSIEDKSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W802</accession>
    <name>A0A084W802_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003858-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014236</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021335">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W802"/>
    <dbReference type="STRING" id="74873.A0A084W802"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014236-RA">
        <property type="protein sequence ID" value="ASIC014236-PA"/>
        <property type="gene ID" value="ASIC014236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014236"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021926"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="97"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="227"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014236-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="411" mass="47682" checksum="A592A249D76FBC6C" modified="2014-10-29" version="1">MNDAKPIHVDDAFASLGEHTLAELALPIHSHLEIDLESQSASFDHFVPPFRVTDSTNDTNGFMLLSDGPDKESLGHSLRIKAELFDTLSNNAEIDHPLCDECTDTLLELMDKELKIAEDEWNDYNNYLKKLEMTDDVPNIAELEQELATLKLDETQLLDELSKLSREEQSVRQAVDEQEKERQRLECEENKYWREYTKHRRDVITTEDEFRSLECQMAYAQSQLEKLKKTNVFNATFHIWHSGHFGTINNFRLGRLPSAPVDWSEINAAWGQTCLLLSALARKMNFTFKQYRLVPYGNHSYIEVLGESKELPLYGNGGFRFLWDSKYDAAMVAFLDCLQQFKEEIVRRDPDFCLPYLMEKGKIEDASTGSSFSIKIQFNSEEQWTKALKYLLTNLKWVLTWVSSQFAEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8C0</accession>
    <name>A0A084W8C0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrous sheath-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014516</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021410">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8C0"/>
    <dbReference type="STRING" id="74873.A0A084W8C0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014516-RA">
        <property type="protein sequence ID" value="ASIC014516-PA"/>
        <property type="gene ID" value="ASIC014516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023761"/>
    <dbReference type="OMA" id="NSLPGWE"/>
    <dbReference type="OrthoDB" id="8197715at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="78268" checksum="F676482D54BD0C7B" modified="2014-10-29" version="1">MSKLLTLRRPTTISKLIQELPEQAESRTLENIPQWSDTPPFGKLPDRQCPVHSTNLSRGALGKPIGRFAGNHGFDTQDPLLQITRVDYHLLHDKHLQKFFTAARKKNLKFHGLIDDEGKVKCSMKLLNDYRKFLYLQIRNNLQIQLRRMDSERKDLNHWHRVENYLNDNEDYNEKLMVRIERSKNIFLDKLNRWKDALDKYHQRIKMIAVERTCEKQQRLSEAHQRDLLNNTRLQELLAHRKRYQLILKRRLHERDDLLKQRITRNKRRNAELRLTRRQEHFRVHYMAYIRERNEAREMLEHWLNETEMKVFERKEMYRRQHMKLEEEMVRRKTGNLTRRYQRRSKKALMQALLHEYKKPTSDSTTSVAKQAIERAINAAYTIHATLSHTIGSSMIIETASQFISDLQENPGEPLPLDKQTVGYVVDRLNEQMELVLQETVKQALKLIEQVVSRKLERIDGINHFRSSLSNKSCNEQETTCSTRVRNAHSRVSLGPVSILEEYETDSLSFKKCKNRPPTPVTSVASMVKCTMLQTEEERSSTARLEISPESAIHLDQRIHSEDYPLIHIMYSQRRCLESNLIKYRKIVHTFVEQRICGCVSDLARFAVADKVPTEVEKDKLLHRTATALLKFPESAQDYASALLASVEYLSVVAMQKICKILNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W952</accession>
    <name>A0A084W952_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP011033-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014783</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W952"/>
    <dbReference type="STRING" id="74873.A0A084W952"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014783-RA">
        <property type="protein sequence ID" value="ASIC014783-PA"/>
        <property type="gene ID" value="ASIC014783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014783"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013781"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016437"/>
    <dbReference type="OMA" id="AYWDAQT"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000179">
        <property type="entry name" value="Chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000272">
        <property type="entry name" value="CHiTinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784668" evidence="9">
        <location>
            <begin position="20"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="467"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="10">
        <location>
            <begin position="899"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="853"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="955" mass="104623" checksum="46B803F61CE6CBD1" modified="2014-10-29" version="1">MKAAVVAGLLLISIASINAATDRVVCYFGSWATYRIGNGKFEVEDINPNLCTHIIYTFVGLDTKGNVKILDNWFDISLGGFSRFVQLKNRNPNVKLMISIGGWNEGSATYSTMANSDLLRAVFVDSVVTFVRRYGFDGFDIDWEYPTLRGGAVEDRVGFIKLLRDLRTRFDREGFILSIGTAATADYLVSAYDVPEINKYVDFVNLMTYDLHAYWDAQTGANAPLYPNVWETGFTTSMLNVDACVRAWLNGGLSSSKLIMGVPAFGHTFKLASTQDTRIGARTIGPGDAGPYTLEPGTLSYLEVCEKLNGGGYTTAFSNEQQVPYAFRGDQWISYDNTYSIALKVQYAKWMNLGGVMIWSIESDDAKGICGEGQFPITSTVFSEVFGGTAPTITTTTTRPTTTTTTTTSTTKVVPATTTTTSRPVVTTTTTTTTRRTTTTKRPTEKLVCPSSGYLRDPNNCGQFYQYKVFCFFNNEAAYRVGAGKRTVDDINGDLCTHVIYNSITLTNTGTLKLLDSYNDVTNGAFNRLQAMRLRYPNVKFMIGLGGATTTSATFSRVVSVPALRQAAVKTIVSFLTQQYQFDGLDFYWQYPVMKGGTPEDRPNFVTFIAELSANMRMYGLVLTLTVAPTDDFFMSSYDVPNLVRYVDYLHVTAFNLHAFWDGKTGHQSAINASGREGSNYEAQLNVDAIISGWIKAGAPSSKLVLGISSNAVTFKLYDEKDNGVGVRAAGRGEPGPYTTTEGIMSFQELCVAKEQDGWTTILDRTQQGYYAHKGRWWVSYDDLPIVLLKGAYAISRSLAGIALFNAEGDDAVNECGKGSYPLLRSVNAGLNRKVPDESGATTTVKPTITTTKTTTSTTMAPSTTTKAPTTTTKAPTTTTKPTTTTTKKPTEATPPPMPQYCPSKGYVRDPSDCAIYYRCIPNGLFLTVWKYTCPSGLLFNLSSSTCEYASKVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W980</accession>
    <name>A0A084W980_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011020-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014777</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021650">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB46774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC014777-RA">
        <property type="protein sequence ID" value="ASIC014777-PA"/>
        <property type="gene ID" value="ASIC014777"/>
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    <dbReference type="OrthoDB" id="7741579at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00697">
        <property type="entry name" value="DM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014777-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="18063" checksum="2D3FB7C0DC00F658" modified="2014-10-29" version="1">MVSKLELKHNDNFLNTTVTTMIDGEKTFNKSYVIEMISVRDLKEIRCFVTYSVLALNGNIQNKLFSRSFDLCQFFRRPNMDRLMKLFYDYLTATSTMPSVCPVPRGFRAQLNVVLTKIPGFFPESDFLVDVNLYTGLRQVPMLESRWIGRIQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9F7</accession>
    <name>A0A084W9F7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002289-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00014855</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021746">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC014855-RA">
        <property type="protein sequence ID" value="ASIC014855-PA"/>
        <property type="gene ID" value="ASIC014855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014855"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018595"/>
    <dbReference type="OMA" id="VFDWDFY"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF1">
        <property type="entry name" value="LD32918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784414" evidence="2">
        <location>
            <begin position="25"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="3">
        <location>
            <begin position="56"/>
            <end position="188"/>
        </location>
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        <location>
            <begin position="197"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="451"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB46851.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="532" mass="61682" checksum="53066FB4E9F36F5A" modified="2014-10-29" version="1">MKPIISKLLLLAVVWSCAACVTLGKNEDPTINRVCRGITTDQQLITLFNENYVPVNCRSSLEGVWQFAYQNRFRFTGECDHPDARIHSCQQAGTQFLISNEKFNITYKQCIGMTETFNGVVEYSCLGDWFVGKNHYFAVANTKESRKDEKYRCFLKNRDDDLYLGVSITAECNTLKTVEKSPERLRITPVKADVIEPGCRFPQNFTGEWINTANIDGDVKINETHIVETYKPDQSRYRRTIYICREQRDTRIMMARLTVDGCQTDYVCFDFVPKHHNIIRYRRGRALIDDDFSTVCAWKQFENKEQWRYELLLAAKPVPIRCPVAGKFNFTQKGEAPFKTRILGGVTLSPRPDIRCKQNISDFSVCDGDQKEMAIDADYCLSVDYLGRPIDIYSDPDYRMSCIGYWQENLKSYLITYDDLDPLSKYRCWVYQRADLNRILMSQAVGAFCNLKQDVTSWNWTEGAVVAIDMTEYERERDQCPMHFDDGSNPWKETENLVTIFQWRIYRSTAAFTSTFTSLLISVAAVFLKVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H9</accession>
    <name>A0A084W9H9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001130-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014878</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021807">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB46873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9H9"/>
    <dbReference type="STRING" id="74873.A0A084W9H9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014878-RA">
        <property type="protein sequence ID" value="ASIC014878-PA"/>
        <property type="gene ID" value="ASIC014878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014878"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018863"/>
    <dbReference type="OMA" id="KDICENC"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="120"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="366" mass="42357" checksum="D6CFE2E72D7DD722" modified="2014-10-29" version="1">MYEASRNSCHCHRLRSIAEQCTCDLKDLYNDRWSYRGHQLNQSLRSFPNHCHGCVQQPSYYVHPDGNETARDLSDIQYSQNQYYPSAVDHSRGRISPRSPPFVTTLPRSSTPTNGCWDKLSLSIWQRFTAIKQTEKTFLQKMNLWGHLYECVQKIPRLPKFELFLMGSTISGFGMEGSDIDMCVVAKDGPLYCDLRTEALENLLHVKQFLDRMPSSNLEQISLICAMVPILRLKHKSDDFDIEISFNNYVGIRNTQLLHCYAQLDWRVRPLVIIVKLWAKHNNLNDPKNCTLSSYSLALMVINFLQCGVSPPVLPCLHELYPEKFSGPVNTDRLKLFERVEAFSTDNDDTLSSLFINFLKYYTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9W2</accession>
    <name>A0A084W9W2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015019</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9W2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015019-RA">
        <property type="protein sequence ID" value="ASIC015019-PA"/>
        <property type="gene ID" value="ASIC015019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015019"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015019-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="12723" checksum="83F84A21671AF3EE" modified="2014-10-29" version="1">MTTASGDVDDDDDDGQFWALGAVDKRRSVRTSAKDTIGGTGTLRALQLEVNRTQNAAAPDEISLVWLAAGSDRSARAHDRAAQTDNSSLSPPHHAGSVNRFRDLNVEWPPPCCTSTSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAK9</accession>
    <name>A0A084WAK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP010505-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00015277</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022202">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAK9"/>
    <dbReference type="STRING" id="74873.A0A084WAK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015277-RA">
        <property type="protein sequence ID" value="ASIC015277-PA"/>
        <property type="gene ID" value="ASIC015277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015277"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017492"/>
    <dbReference type="OMA" id="VREICVQ"/>
    <dbReference type="OrthoDB" id="7757313at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015277-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="386" mass="44535" checksum="60A93605BA77D6D5" modified="2014-10-29" version="1">MNCTVSHDLYIHNLNYIRWCANAFGMDVMAPNFKPNWKTFIAVGIVSIALFGQFYSVWYFWNDVVKLMESTALYALILQGCTKFYTGLRYYDFFIAMYGRLDRLHQEHRTHPKNNAALLLLMQRIYLLTRLIGVQYAFSASVFGLIPPLAYLVTGERMLCVSLVIPFTDPTIPSHYFLNLAWQYYMLMLAIAGFSAAESIILLFVGSLAGYADILKNEIDELNTILQDAERTDDRSMVKKKIHDIACLHQRILEYENDLEERYYLNNFVQVFSIVLTLGGALFLCLVTNSISMYTLAISGVIQLFELCLLGTILSVKNEEIEATFYNSLWYLMDRSEKSTFLILFHRSQHAVEMTVANMGSLNIVLFVTILRKIYGFSMMLMNFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAQ1</accession>
    <name>A0A084WAQ1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serendipity locus protein alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00015325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015325-RA">
        <property type="protein sequence ID" value="ASIC015325-PA"/>
        <property type="gene ID" value="ASIC015325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015325"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009846"/>
    <dbReference type="OMA" id="FTCFLDF"/>
    <dbReference type="OrthoDB" id="6342160at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007349">
        <property type="term" value="P:cellularization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008837">
        <property type="entry name" value="Serendipity_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF33">
        <property type="entry name" value="RE47911P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05482">
        <property type="entry name" value="Serendipity_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="75749" checksum="086C4BA3B58CA4B1" modified="2014-10-29" version="1">MLPELQECITKTQDNLYRGYVPTDQSGLQWLDSVCADLHRLFRIVHKYLMFEQNGNVGTLETCFLCISQIVTCIRWLEKTITMELKAGKRQGLPQSRQCFLDRIIWCLERLKAVLETDVPCEAVTESNFVSYLDLALSLISPLTVASDEDCTEDEYDRQYNAVLVESGRIRSIIEALITQTFGFCNVLPEEDRKRITNFCQKVLKECLALERESNERDSNSKKLRVSILESAIYQLEKHVNECLLRLVYETFGDTDRRLLSQLRENITSTASEDELDGITQPFDEYVERLMQIGLFAISYADNLKLCSAIRSSLASIEALDSYLIPSLYMGTHNNTILLEQHWLEESDILCKHVHKIIDTNAFALALIEQLDAKLDEFETDFKPTEGLEMARKVEIFLQHLEVNANEVKLHEEPLKLYYADYRTMTLECRAIVKCAQQDDSIDPRRVIKRFRVLLGKLRKIQLTISNKKGGKVPLAEETASGKPSTVEQGSSPAEHEVEESVQELYVASQLRMSSANILYRSRRGEPIRRRLEASSLLEINTFTDILDHRRKRAETSPEKGSIRRKPIRRNSLRVAMFKKQQRVQTAEMYDSMQSDIDLQITEILDELTDLSNTFSTQTPRISNPKVTNPPDTAVRKSIANEEIAVVDGNKIRIHIFTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAU4</accession>
    <name>A0A084WAU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Phosphomannomutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015426-RA">
        <property type="protein sequence ID" value="ASIC015426-PA"/>
        <property type="gene ID" value="ASIC015426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015426"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6094" checksum="CE427E0DA978972F" modified="2014-10-29" version="1">MPFKDFLRHLSTVSEMDKDGPDLPTRDVPSPVEGYASHNVQTSKGNHGRVGLIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB41</accession>
    <name>A0A084WB41_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012166-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015380</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB41"/>
    <dbReference type="STRING" id="74873.A0A084WB41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015380-RA">
        <property type="protein sequence ID" value="ASIC015380-PA"/>
        <property type="gene ID" value="ASIC015380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015380"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012787"/>
    <dbReference type="OMA" id="FTMIGDI"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="334" mass="38098" checksum="E73649E9DB3B771B" modified="2014-10-29" version="1">MSAKVDTLVKEVFPAPVADIKMTQVRPIPECLKRKAAEELNEKENTITEELEVIKTWMRQSGHIRGRLEDQFLLGFLRSCKHSLERVKEKLDTYYTIRSVLPEVMRGRDPLDPFVRKVIRMGVTVPLPKTVHPDDPKIILIRGDAFDGDACDFPDILKVFTMIGDILLRDDDQMMICGQAAIIDLGHSSSGHLFNFNLSFLRKASILNQQASPLRQKGFHFINTPKGFDIVLNIFKSLMTEKNRKRTILSHGSSLESLHKHFPKSILPAELGGELGPVQQFVDEWEQRLIDNRTYLIAEESLGVDESRRRNTNPLAEEKDLFGTAGTFRKLEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBG3</accession>
    <name>A0A084WBG3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AGAP011441-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00015521</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WBG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015521-RA">
        <property type="protein sequence ID" value="ASIC015521-PA"/>
        <property type="gene ID" value="ASIC015521"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015521"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007469"/>
    <dbReference type="OMA" id="CIEWQRY"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1251"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1532"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1885"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="2730"/>
            <end position="2795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015521-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3898" mass="447215" checksum="FB05693F98A2F99D" modified="2014-10-29" version="1">MSKRLAKLHKPCDKLDKYDNEPYMQNPLLKLFLSEVKERRHYSFIRRKAAAEKIKICRSKTVDFEDVIPRPQSYYAEQLREHARRAPVPKMLASTEEKILSYVPKRLRAQYPGVLAAYMTDVHAEFDKVMKAYSCQKILKPGPDDYVPERVKFEFKRVGRTENYRNYLRSKAYIQKNLLLPYPFVRCIVHYAFTDLPVYLNDYARYRTGEEITLNELRDLIKKDLQAVGALIAGQWYPKIVAILKKHYERRALPKSMWPKVLNCAGALINRELNEAKLRTIRHLQETLLNVRQIPQMKILAICDDGIDLFPSLNDIYSVYQNAIVDVMAVGNRLDCLESLVDPTTFEPKSPPYLRVGIAERCVQEAHEQVQEALTKAFQPLTEYLSDFQARFAGLLCPSTKEDLDEFLSEPRTFDEYIAKIEAFQHYKEMIRAMVQKEYFPMAIVNQSDAIGSLRKIVERYIDRVANHIAIEHRRELDRICKEFVEIKEKALEIPTSTEQLMANGEYMTRVKSEIIDALRDKIQTTMRVNAYLVELMELPADQIELQVDSVNWYFRIQSVFEINSTNFEQYKFSFEEKLQEVTKQLNEKMEEMIPHIAIINDMTETEKFRDYIVVLHGYIDQIFVFEDYVKWINKEEVLFKFPKSQYTVLEAIKSFVVPFYKLIRLCMRWLRYYNVWMDGPFEYLEPHFVESKTDEFLKEFQKTQKYYRNRIKADMLENTLCKFKGQTEDPDPEKHPCPLKLCARMSQSIKDFHLGVYVVKIMCNPALKDRHWDEMSEIAGFDLTPDAGTTLRKIINYKLEKDLDKFEIISIGANKELALQQSLQAMIAEWEDIVFKLGAFKDTGINILTGLDEIQAVLDDHIMKTLAMRGSAFVKPCEKEVKEWYQTLTRVNRTVDQWGKVQGSWLYLLPIFSSKDIVAQMPNEGRMFQQVDKTYRMYMRTVEVNRSVIGVAAAKGVQEAMEQSNELLEEITNGVNEYLERKRLYFPRFFFLSNDEMLEILSETKDPLRVQPHLSKCFEGINRLEFDERLDIRSMFSIEREQVQFVEPVSTVEARGSVEKWLLWVESGMLGAVRHEIRASYRAYREKTRCQWALEWPGMVVLCVSQIYWAAGIHQCFRKRNNTLILDLFERLQVELMDVVALMRSKDLTNLQRITVKALIVIDVHAKDVVQELIRNRVSAEDDFQWLAQLRYYWEGGQEDRDDGEEGSVMVKIINAAVPFACEYLGNSDRLVITPLTDRCYRTLMGAYQLHLNGAPEGPAGTGKTETTKDLAKALAVQCKVFNCSDGLDYKAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIVQAVRAGVQRFVFEGTELTLNPACYVCITMNPGYAGRSELPDNLKVLFRTVAMMVPDYAMIGEISLYSFGFTDARTLAVKIVTTYRLCSEQLSSQNHYDYGMRAVKTVLQACGNLKKAIPDEDEEIILLRSLLDVNMPKFLAKDIPLFEGIISDLFPGVALPRADYTQLERAFREVCTEQNLQPRGTFLEKVIQTYEMMIVRHGFMLVGRPFSGKSTTLRVLAACLAKLKNARTANPYFQRVQLEVVNPKAITMGQLYGAFDPISYEWTDGIASTIFRRHAMDTAPDRKWLVFDGPVDAVWIENMNTVLDDNRKLCLTSGEVITMTASMSMIFEVMDLEQASPATVSRCGMIFMEPSVIGWESFVESWIQRCNNSWTHDWHDLLMELFRWLIPDCLEFIRTHGHQYLHPGDTNLLMSTLHIFEMIIDEACHESPDEYGKYLFTWFQAAMMYAVVWGLGGVLDMESKVKFDEFYREIWKGTDELHPIPEVVGKIDVSMPGEGMIIDYVYHFKQKGSWRYYPDMVRQMKNEVGFTLLVPTLDSVRYMHILDIHVKNKKPLLLVGPTGTGKTYYIQNYMMSKMDQEKCLPTFITFTTQISANQTQELIISKLIKKKRGIFGPPNGKTCVLFIDDMNMPVKEVYGAQPPIELMRQFFDQGHWYDLRDTSKVHLKNILVMAACGLVGGSRQDVYERFLCHFNIFAISNFNDETMFKIFSAILLDGYKKGGHASDVINMVNMIVNATLDTYQFACVQLLPTPAKSHYIFNLRDVLRVISGCAMLKRESVESKKIFPKLWLHESMRIFYDRLVNDADRAFVFEKLLANLRTFFKEKPEALLPELFDESTGEVQLDSLSNLMFGSYFDADADTEDRKYEETAHVEQLRDLAGKALAEYNSSQAKAKMDIVLFQYALQHLNKVCRVISMAGGSSLLIGMGGSGRQSLTKLAAQICGQSLFQPEITKFYGLNEWREDLKKVLKEAGGLGHDTVFLLTEAQLQQEAFLQDIDCLLNLGEVPNIFAIDEKQEILEMVRLAAQGGNRNLDISPLEVFQFFVNRCKQKLHIVICFSPIGGALRTRIRLYPSLVNCCTIDWFDAWPEDALEKVAEKYMKELSVTAEVKRSIVQLCKHFHVIARDVSREFTAETGRITYITSASYLELIKSFRNLTQRHQTEIMNNKLRYLGGLDRLSAAADAVSKMQTELNALQPTLIVMAENSRKMTEEIEKESLEATAATEQVKKDEVVANVQAAEAQVLKADCEKDLAGAIPILEEAIQALNTLKPTDITLVKSMKNPPEVVKTVMAAVCVMKGIPPDKVADPATGKKMLDYWGPSKRLLGDLAFLQTLKDFDKDSINPDIMRKIRKDFIPHKDFQPHIVAKASSAAEGLCKWVIAMDLYEAVAKIVAPKKEKLKQAEKEYAETMAILNEKRLLAANLERRVAELNDNLEIANRKKQEVEDEVQLCKDKLQRAETLIGGLGGEKSRWISSAEHLQRLYDSLAGDILVSSGVIAYLAPLTAPFRNRCIGEWHKLCVANSIPCSPEYNLVEVLGSKIKIQNWNIAGLPTDAFSTENAIIMDCSSRYSLFVDPQLQANKWIRTMERNNHLVVVKFSQADYMRKIENCIEQGYPVLVENVFEELEAPLDPLLNRNTYVQGGVEYVTLGENVLPLSPKFRLYLTSSLRNPHYLPEVYNKVTVINFALTIQGLEDQLLGIVVAKERPDLQELRQSLILQGAKNVSMLKDVEDKILKTLSECKGDILEDESAIKILDDSKRISSEIVRKQEDSREIEQKIEAFRQSYRPVAMHSSTLYYCITELPNVDPMYQFSLAWFVNLYVYSIENANRTKELYRRLKYLMDAVTLNLYNNVCRSLFEKDKLLFSFILTTKIMISCNQIDSREFKFLLGVSETPTDRPALPNPDVSWITTRLWEDVCRLEQLPDFAGFVESFAANLSLWRAYYDAEEPQMLKLPEPWDEKTNRFEKLIVLKTVRPDKFVLAITEFVASEMGPPYVAPPPFDIARSFEDSNCLTPLIFILSPGADPMNALLLYAEKMGFDETFQSISLGQGQGPIAQRIIEKAQEEGSWVCLQNCHLAASWMPTLEYLWENMDHYNTTTSFRLWLTSYPSEQFPASILQTXXXXXXXERRKFGPLGWNIAYGFNESDFQISVLQLQLFVNQYEEIPYEAITYLTGECNYGGRVTDTWDRRAIVTILEDYVNEHVVNDPNYRLSSLAECYGIPLRNEHREYLAHIANNIPNFPSPLVYGLHPNAGITRDLSASKTLIDAMILTQGGTTGGSDAELEQQVLATVDEIFALLPEDFNLDAAKRRYPVDYGESMNTVLVQEMERFNALLGEIRSSCVNLRKAIAGLIALTPQLESVFGAIQHRRIPASWMKKSYPSLKPIGSYVVDFRRRLDFLQQWNDDGKPCVFWLSGFYFTQAFLTAAMQNYARRYRIPIDMLTYDFKVLRAGDGTPSEPPEDGVYVNGLFLEGARWDQEKACLDEQLPKMLIDTMPILHLLPTKLTELHEGTRYKCPVYKTAERKGTLSTTGHSTNYVLPVLLATQVPANHWVKRSVALLCQTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBQ2</accession>
    <name>A0A084WBQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015688</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015688-RA">
        <property type="protein sequence ID" value="ASIC015688-PA"/>
        <property type="gene ID" value="ASIC015688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015688"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9434" checksum="2FEC81188992BA8F" modified="2014-10-29" version="1">MGGVIDSRCLPTGFPGHPKHADRLSENATGLRARLKVIRGEKGAEFGGSGRWYRGNWEVFVYDMTQSAPYGVRPPAVVIRELFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDR6</accession>
    <name>A0A084WDR6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005020-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00016480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transglutaminase-like superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDR6"/>
    <dbReference type="STRING" id="74873.A0A084WDR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016480-RA">
        <property type="protein sequence ID" value="ASIC016480-PA"/>
        <property type="gene ID" value="ASIC016480"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016480"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014686"/>
    <dbReference type="OMA" id="SLFHKGC"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000108">
        <property type="entry name" value="LIM domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016480-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7755" checksum="CA5524F439AD0016" modified="2014-10-29" version="1">MYRPNFYESTCLRCSEIVYQVDRVGPLKDFTFFHSGCFKCKRCGTKLTLKTYYNNQHNQDDKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE52</accession>
    <name>A0A084WE52_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003181-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00016589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB48496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE52"/>
    <dbReference type="STRING" id="74873.A0A084WE52"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016589-RA">
        <property type="protein sequence ID" value="ASIC016589-PA"/>
        <property type="gene ID" value="ASIC016589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016589"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001765"/>
    <dbReference type="OMA" id="IYCQLPK"/>
    <dbReference type="OrthoDB" id="10251219at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="CGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379">
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    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB48496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="385" mass="42035" checksum="7F4292F72C85B61D" modified="2014-10-29" version="1">MSAFSSLAFSAVEITNLLPLTAVIVCIGATIMFLIKAAVILRVQADDVLRPSNVAQQNHNVHVPRLKMTRVHIPFTFRLLDAGNNSFDEVRLAVSSQVRYSLQAFWGVSIRELHVSLWRTWNDLRKASSSLIVDSSYCQQLATNVRCCQPHSEHIIALQSPKPPLILGAPPRLAYPLVVFMIRETEPDELLHPDETVILVNVVHLRDPVCPLPTSILAQYLKQASGQLSCLKVSGKPLAILACLAAHGAESNGGAGSGASSGVPTGTLSLAEPVACAGNNEPLLCSDSAPRDCPVGEQLCVVCHYFPLSRALLPCRHTCICAVCFSKLDRCPMCRATITSYFCIRNEEYLPANTTNELKVNSKPKGTVHWLDALNDRLTDFLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF54</accession>
    <name>A0A084WF54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative potassium transporter 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017106</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017106-RA">
        <property type="protein sequence ID" value="ASIC017106-PA"/>
        <property type="gene ID" value="ASIC017106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017106"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7308" checksum="47D50727984BE334" modified="2014-10-29" version="1">MAQKLAAAAGTVGIGHLRAWERQLRYRDSDGEILHTGCDEIQIIPSTPHQSNTDRFAHRRNGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFX8</accession>
    <name>A0A084WFX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023409">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFX8"/>
    <dbReference type="STRING" id="74873.A0A084WFX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017275-RA">
        <property type="protein sequence ID" value="ASIC017275-PA"/>
        <property type="gene ID" value="ASIC017275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017275"/>
    <dbReference type="OMA" id="YDVEHIN"/>
    <dbReference type="OrthoDB" id="5988548at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8097" checksum="A22058FE06A926C8" modified="2014-10-29" version="1">MTTVSLSRMFRGKFRTNTCRIVVLTSLVWLLIDVILIVKYADCPSTGGGSSWLCKTNNRGEYDGETLSVQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGD2</accession>
    <name>A0A084WGD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017389</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023533">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023534">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC017389-RA">
        <property type="protein sequence ID" value="ASIC017389-PA"/>
        <property type="gene ID" value="ASIC017389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017389"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="15011" checksum="CB5E1959F4169737" modified="2014-10-29" version="1">MCPALGENWPERAERGGPFDLVMGVYGRVGVERXXXXXXXXVTMKVKVFASRPCHHTTAGQSRSVGVQRNQIRCWKIGRDRHGQRDLFDTLPGSAYGPPITAANVSRINISRGDERHINRRTGRLCIAEPAVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGZ2</accession>
    <name>A0A084WGZ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017687</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGZ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017687-RA">
        <property type="protein sequence ID" value="ASIC017687-PA"/>
        <property type="gene ID" value="ASIC017687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017687"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10874" checksum="7F94423DDF1EB6F4" modified="2014-10-29" version="1">MHSAGSVCYFGCSVAVPKGQSVTKNFNASASEQPLLPGRRSGVEGASRWQQNNMALPNEVTCVLQQQPRLSLTLLPGFPSRPYRTIAVPKTENISTLLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI56</accession>
    <name>A0A084WI56_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP010577-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00017930</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI56"/>
    <dbReference type="STRING" id="74873.A0A084WI56"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017930-RA">
        <property type="protein sequence ID" value="ASIC017930-PA"/>
        <property type="gene ID" value="ASIC017930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017930"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018547"/>
    <dbReference type="OMA" id="PLIKECW"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09193">
        <property type="entry name" value="PLDc_mTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000039">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000051">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="13">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017930-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="626" mass="70059" checksum="EFA1FDB90146C035" modified="2014-10-29" version="1">MNSNVPTKQCQYGADCYRVNPVHFREYSHPHIENVLAKASSLKDVKIPDTLNINKSVFEEQLKIVSKLFPSLSSEPNHNPEKKVKIDDNRSSPTPLNMPTASTSNAEPKASSSSTSTSKNSIDALFAERRARMQAAQREKPAPAPAPVQPAPPQSVPEPASNSSNTGISLQQSLPRDINSYFPVVAPRGRMAEKLAAAAPYNFFLTTITASKPTHTEPLSITFQELLDASLGQLESSVQMNFMVDIGWLLAHYFFAGYENVPLLVLYGDETPELKMVSKKKPNVTAVKVDIKTPFGVHHTKMGLYGYRDGSMRIVISTANLYEDDWHNRTQGLWVSPRLPAVPEGSDTNYGESVTDFRANLLAYLEAYKLPQLQPWIARLRKTDFSDIKVCLVASVPGGHVNTPKGPLWGHPRLGHLLAQHAAPIDDTCPLVAQSSSIGSLGPSPESWVLAEIMASFRKDSAPVGIRRQPGFRMIYPSYSNVRQSHDGLLGGGCLPYVRNTHVKQEWLKDYLHQWCSRTRHRNKAMPHIKTYCRWSHRGLYWFLLTSANLSKSAWGVYNKTGRFEKPLRINSYEIGVLFLPKLMLDENFFPMDGNKKHPAFPMPYDVPIVPYAPEDTPFLMDYLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIV3</accession>
    <name>A0A084WIV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018208</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018208-RA">
        <property type="protein sequence ID" value="ASIC018208-PA"/>
        <property type="gene ID" value="ASIC018208"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018208"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018208-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8060" checksum="91E68F9822328543" modified="2014-10-29" version="1">MEDGGCLGGGGGGGKGSPTAKNGRRKAQALENCCCCFGCPGLHIRSKTPEAVGGLLVLAGLAQGVRDQVIATGSAPKSDSSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIW0</accession>
    <name>A0A084WIW0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018216</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018216-RA">
        <property type="protein sequence ID" value="ASIC018216-PA"/>
        <property type="gene ID" value="ASIC018216"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018216"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018216-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="15707" checksum="0B535006F836E754" modified="2014-10-29" version="1">MLQNKPESSSRTNPNRATRLSGTGLNSTTAETSSIVTIDLTIGSDDMNISETNGTERRDSVQPDSTVLYTDCSIDLTEDETPSRMSQRSNVSPTAGQVTRELAQEGGGSGLQQTAVSGRRSTPLPLNPSPTHFRRSVAGCRLPRLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ38</accession>
    <name>A0A084WJ38_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00018304</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ38"/>
    <dbReference type="STRING" id="74873.A0A084WJ38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018304-RA">
        <property type="protein sequence ID" value="ASIC018304-PA"/>
        <property type="gene ID" value="ASIC018304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018304"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015464"/>
    <dbReference type="OMA" id="GWCEGFN"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07626">
        <property type="entry name" value="BAR_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11763">
        <property type="entry name" value="SH3_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014536">
        <property type="entry name" value="Snx9_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027744">
        <property type="entry name" value="Snx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="251"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR027744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR027744-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018304-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="594" mass="66061" checksum="EDD128F3C2A684F1" modified="2014-10-29" version="1">MTRVKVLYDFDGEPNSSEISIKVDEILTVTNTDVGEGWWEGMNSRGQRGLFPAAYVETISDAPQMPPPPAAAAVMMAQSVGQQKASVTSAGGWNAGGGVAKSTSQPAIAAGGNRYDQTADEWGEQQDDWDDDWDDDNDTYSEIGPGSTAGAGSRANGAGSYQQQQPAASYYANANNLPPLPAPDGDSMSLASVATTTVGGRRAAGSGKIFSKSGDTYLMGLPVPDVSEAERVQVLAMEQQGIVWKPMRDTYTVSVDSPKKEKKFNGLKSFIAYQLTPSFNNIPVARRYKHFDWLHERLVEKFCLIPIPPLPDKQISGRYDEEFVEHRRVQLQEFVDWVCRHPILSTCAVWMHFLTCTDEKKWKTGKRTAEKDPLVGTMFCASIFPPEKTLLPSQVDPQVEAANMFVPQMDAAVKTLFAICGDQSKKFQVQWKKEYQRIGEGFSEMARALGTDERRATTQISLSNSVGQAAGVFISIGQLFGEQPKHDFVPFSDRLHIYRGLLAGWPDTLGEYRNAVQKRKDCERLTAEQKMDNGQMQEVNRRVDVMSYALLAEMAHFRDERDTHLKDTIRNFLGAQIDFYKSIVQKLEQAQSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ51</accession>
    <name>A0A084WJ51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP011768-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ51"/>
    <dbReference type="STRING" id="74873.A0A084WJ51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018321-RA">
        <property type="protein sequence ID" value="ASIC018321-PA"/>
        <property type="gene ID" value="ASIC018321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018321"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001552"/>
    <dbReference type="OMA" id="YVCPYNS"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000022">
        <property type="entry name" value="Growth factor receptor-bound protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB50245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="21102" checksum="34CD83607A40B423" modified="2014-10-29" version="1">MEDDMNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCSDGVQHFKVLRDAQGKFFLWVVKFNSLNELVDYHRTASVSRSQDVKLRDMVPEEMLVQALYDFVAQESGELDFRRGDVITVTDRSDEHWWNGEIGNRKGLFPAIYVAPYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKV7</accession>
    <name>A0A084WKV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005207-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00019166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKV7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019166-RA">
        <property type="protein sequence ID" value="ASIC019166-PA"/>
        <property type="gene ID" value="ASIC019166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019166"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002729"/>
    <dbReference type="OMA" id="KQSQGMP"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="739" mass="83319" checksum="C3EF1F3A07BBE031" modified="2014-10-29" version="1">MFSKFKSSTTSAPPQNPYDNNPITQYFEIGKQIACAGPELIWKIHEGYRKTDGKECSIFVFEKRTAEKLHKPKRKETVTEILRASVKQLERFRHPKILQIMHTVEESSETLSFATEPVIASLANILAYQEAGGTIAGPPSTGASGQHCPTGVPRPAHAKEYSFLDIELKYGILQITEALSFLHYSGQVIHKNVCPSSILITKKGTWKLAGFEFTERTNETDATDPVPCQPWSTRASKLVQPNLDYMAPEIQINSSCSILSDMFSLGMVICAIFNHGRSLIQSGNSPSTYLKQMELLDEAVHNILPRIPIPLQEATTRLLKKSPGPRPTAQLLTLIKYFSDPAVQALQFLDVINMKDPTQKTHYYRSTLREVLPFIPRKLWWQHIWPNLQQEMRADEVLAAVLQPALTLVQESSNTEYEAIILPTFKTVFVAPKSIQATVALLENLHIILEKTPRDDIRTEVLPLLFNALESTTIQVQSAALVAVTNVYDYLDDITIKKLVLPKLKSVFEKNQSDLKIMGNVLQCVERTLDKLDKSQIIDEVLPLLLEVRLTDPDIVVRVVNIYRIMLCDKKYGLTVNIMATKVMPTLLPQTVNPSLNLEQFMILLEVLQEMLDQIDRQQRNKLKLDNLSLPSPDRHRPLRHQFSSDNMNAQQFNIPNLRIDQRKTSSAEDMARKNSTGSGALGSWWFGGSPSSPDSNFLRVVNAFPNRRLSDNTLMTPKIRIAPSCASSPGESVGRWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM58</accession>
    <name>A0A084WM58_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00019354</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM58"/>
    <dbReference type="STRING" id="74873.A0A084WM58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019354-RA">
        <property type="protein sequence ID" value="ASIC019354-PA"/>
        <property type="gene ID" value="ASIC019354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019354"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020107"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000130">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="16">
        <location>
            <begin position="83"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB51302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019354-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="247" mass="27201" checksum="94E3BD33B266E256" modified="2014-10-29" version="1">MFVLAELKDNVRIAPELFGLKLPEAVRDEINRKLANKVLLNVGLCIALKDIVKLGDSIILPGDGASHTEVNFRYIVFRPMIGDVITGKIRSCSREGVHITLGFFDDILIPPSALQHPSRYEEAEQAWVWEYPLEDGKSHDLYMDIGESIKFRVSGEVFEESSPVGPPDQEVPSGAAGPSSSGAGTSGTTPQDANKTPYRIVAAINESGLGLLSWWVQQNQEEEDEEEEEAEGEEQEQDQAMSGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMH3</accession>
    <name>A0A084WMH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP006136-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019895</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMH3"/>
    <dbReference type="STRING" id="74873.A0A084WMH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019895-RA">
        <property type="protein sequence ID" value="ASIC019895-PA"/>
        <property type="gene ID" value="ASIC019895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019895"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000723"/>
    <dbReference type="OMA" id="FYCNRNR"/>
    <dbReference type="OrthoDB" id="186812at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140911">
        <property type="term" value="F:pore-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB51417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="366" mass="40774" checksum="E75F890CB7109649" modified="2014-10-29" version="1">MQDGLISRAGASICNDPYADKGTGKYSAMNGTGMTTTTTMATPSAKQYSPTKSCQNHQPRQPPSPTHHTTGAEFKLCGYDCGPMMAGQTTDDSSRPHSPGSPKTDMFGVLEFWIKLRHDLRTLPWEQLKSVKLKNPRAAPGCAYIPTQVEHIANVLTHGFWILPSIYGGSNLYWRSYTPAQTLAAIIYGAALTMLFFVSTCFHCVCYCNHNRPLKDALHRCDRAMIYIFIAGSYYPWLSLGHTTHPQIVSVVKWCVWVMAVLGIIYQQMYHERYKCLETFFYVVIGLGPSVVIVLWGHEFTGMSELKFGGLLYIVGIVFFKADGLFPFAHAIWHLFVVFAACVHYFAILTHLFPVPTSTGVAEAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMI8</accession>
    <name>A0A084WMI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019912</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024465">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019912-RA">
        <property type="protein sequence ID" value="ASIC019912-PA"/>
        <property type="gene ID" value="ASIC019912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019912"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8767" checksum="4524F5D9067147C4" modified="2014-10-29" version="1">MECTSLESNAGGHHFGAVMFPGVSTRFRSLDEDSNLQIRPPHDTVLKAQASREFVIQHAPARDTRDDERLAVSRCTALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMZ9</accession>
    <name>A0A084WMZ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00019664</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMZ9"/>
    <dbReference type="STRING" id="74873.A0A084WMZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019664-RA">
        <property type="protein sequence ID" value="ASIC019664-PA"/>
        <property type="gene ID" value="ASIC019664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019664"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020932"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF82">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="280"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB51593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="519" mass="56834" checksum="9EF08574430E5511" modified="2014-10-29" version="1">MASGAAKKFGDLVGSIDEGTSSARFLLFRAETAEVVCFHQKELRQSYPQEGWVEQDPNEILAVVHECIERTLEKLVELGGNPSTDIVAVGVTNQRETTIVWDRTTGEPLYNAIVWLDMRTSSTVEQLLETVPNKTKNKNYLKPLCGLPLSPYFSAVKLRWLIDNVPKVKAAIRNGNCLFGTVDTWLIWNLTGGSEGGVHVTDVSNASRTMLMNIETLQYDKTLGKFFDVPLEILPEIRSSSEVYGLIKFKPLQGIPLSGCLGDQQSALVGQECLTRGRAKATYGTGCFLLYNTGTAMIDSSHGLITTVAYQMGPDAQPVYALEGSVAVAGAALGWLRDNVNLLASASESEVLAHTVENNGDVYFVPAFSGLYAPYWNQDARGVICGITEDTQRGHIVRAALEAICFQVRDILDAMNNDCGTPLQKLKVDGGMTVNASMMQWQADLIGLDVLKPTFVETTALGAAMVAGRAVGKWDIENVSIESSCTAFKPQISEDERDMRYSKWKMAIERSFGWENNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPD0</accession>
    <name>A0A084WPD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP001781-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00020261</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525368">
        <property type="protein sequence ID" value="KFB52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPD0"/>
    <dbReference type="STRING" id="74873.A0A084WPD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020261-RA">
        <property type="protein sequence ID" value="ASIC020261-PA"/>
        <property type="gene ID" value="ASIC020261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020261"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019570"/>
    <dbReference type="OMA" id="ARKDHCH"/>
    <dbReference type="OrthoDB" id="7733558at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="536" mass="58626" checksum="74D371A990DE6067" modified="2014-10-29" version="1">MSSLSSDFVTSDNQLGAWGTYPYGYSEFTMPGSDWFTSLSTDLEGSPLAYDPDMQHKEPYQVHQPAGGLHRISPLDSPVEVAEADSTQHYGYPFSMHQHLHHGNHPGGTGDFSYQNQKQAPPSTKSSTNAGARFVPHGYYNPSVRTMPSAAAPTPPQSSMYPSPPGQMLKHADVPSFNKPYGLLYVNGDHVPQPMAYNECPVPCGTQPPSDLYQPYAGVHTTPTYEGNLPSFQSVLPTGIDSVLPTVKYEWGSSSVSPLSPGTNPTSLNTEPCFTVKEEYLATYHSPSPSSLAGGSSIKAELMSDTSQTPPPPLAAGVPPMQTPSPQLLPPLESAYVPENKLIKQQSNGTSVVGPPMSAALKKQARNNYGTLFSCPECDRTFARQCGLTQHMKWHHSGEKPFRCTTCGKCFSGEEALTRHFERHSAIDKPHRCHVCPKAFFHKNDLRRHVYQHTGAAPHNCKYCGKAFARKDHCHSHEYSHERKVERQERKSKARERSEMDKLVPTNGVSVASSPSSSQLGSPMNQLSSPSGLLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPN9</accession>
    <name>A0A084WPN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000295-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020289</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020289-RA">
        <property type="protein sequence ID" value="ASIC020289-PA"/>
        <property type="gene ID" value="ASIC020289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020289"/>
    <dbReference type="OrthoDB" id="6258237at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020289-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10847" checksum="FE2293F60F3F497C" modified="2014-10-29" version="1">MMAETVVTVETPNRNATPAAPADAQGKSESNLNWLKLNPQYFRTIPGILKIVQVTFTLDFRANGTEAWALSWEFVLEHQLYVVRWLQLHLIVLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQG4</accession>
    <name>A0A084WQG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008952-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020697</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQG4"/>
    <dbReference type="STRING" id="74873.A0A084WQG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020697-RA">
        <property type="protein sequence ID" value="ASIC020697-PA"/>
        <property type="gene ID" value="ASIC020697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020697"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016102"/>
    <dbReference type="OMA" id="QFERSIY"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08028">
        <property type="entry name" value="LARP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12541">
        <property type="entry name" value="RRM2_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF166">
        <property type="entry name" value="LUPUS LA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="130"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="8">
        <location>
            <begin position="245"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020697-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="421" mass="47694" checksum="729F4C2AF3D7F18C" modified="2014-10-29" version="1">MTETDVQVAKPEEPKAEGENNENENSPALTASEAAIIRQLEYYFGDANLAKDKFMKDQISKDEGWVPLDVLLTFKRLKSLSDDKKVIVDAISKSEEGLVEVSEDREKLRRHPERPLPEMNEETRKEIYTRTVYVKGFAPQDGTQMDELVEFFQPYEKVVNIVMRRYYDKPTKKYLFKGSVFVTFATVEQCEKFLKEKLAYKGKDLICKMQNDYFAQKQVEEKERKQKIEERKRKKEEAKMADAPNLPTGASVSFEGTGADTTRESIKEQILTVDDTLAVAFIDFQKGDKAGFVRFTEADAGKRFVGKLTENKLKIDESEVTFELLEGEKESEYLEKIVLAKQARRKGGNVKGKGGRGNRGNNNRHHGGGHNKRQRDNGNDGGDDEPPVKKADTADAVKEGAKEKPATEEKKTPAKSEVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQJ5</accession>
    <name>A0A084WQJ5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00020733</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01025637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQJ5"/>
    <dbReference type="STRING" id="74873.A0A084WQJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020733-RA">
        <property type="protein sequence ID" value="ASIC020733-PA"/>
        <property type="gene ID" value="ASIC020733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020733"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018352"/>
    <dbReference type="OMA" id="STYHYWA"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785108" description="alpha-glucosidase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="40"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="646" mass="73516" checksum="EC88F04D38610EC6" modified="2014-10-29" version="1">MASYRRASLCCRFLVWLGLAVGISAASDQGDWWQRTVFYQIYPRSFMDSNNDGVGDLRGITARLEHLKDAGIGATWLSPIFLSPMVDFGYDITDYTVIQPEYGTMEDFEALVAEAKRLDIKIVLDFVPNHTSDQSDWFRRSVAREAPYTDYYVWHDGREDPTTESTNGTQRRLPPNNWPSVFYGSAWTFHPERGQYYLHQFTAQQPDLNFRNPAVVEELREVLRFWLRKGVAGFRIDAINHLFEAEGFPDEPESGTDTDPLSYGFTNHIYTKDLLECYDMVYQWRELLDEWTREYGGDTRIIMTEAYANITFTMRYYHSENDPPRPGSHMPFNFLLITDLSQTSTAPDFVHTINKWLTYMPRTGATANWVLGNHDQPRVGTRYGPERIDAMNTLLMTLPGIAVTYYGEEIGMVDNPDAGKAELEVETGKAFIAFSRDPERTPFQWDDTDNAGFCSGQVQPWLPVHPNYRQLNLAAQRRTERSHYKTYQRLVRLRAHETFRQGSVQLVPYSNDIIAYVRELADSDTFVVVINLAATAHTVDLLAVFPRLALELQVASSGSNSSHPTGAIVQSDRLTVDGYDGLVLRSIPLASRKNKFSLPVNLWAAAKDAAVIASIVIALGTGFYHFQHRFQRIADGGAKWLGGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQZ1</accession>
    <name>A0A084WQZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP010961-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00020887</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525401">
        <property type="protein sequence ID" value="KFB52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WQZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020887-RA">
        <property type="protein sequence ID" value="ASIC020887-PA"/>
        <property type="gene ID" value="ASIC020887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020887"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021608"/>
    <dbReference type="OMA" id="XSIASIV"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020887-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="183" mass="20945" checksum="B523E4421BF7E9A7" modified="2014-10-29" version="1">MSLALSDLLFASLLIITAYFGWRKQNYWNRVGVPYIPEIPVIGNFSTIFLQRHSTFGYIEHIYHHARTRLADFFGVNIFVRPALVIRNPELIKKITCTDASYFLNRQMCADRFHDAIGYFNLIMIQDPLWKQLRGLLSPSVTSAKLXXXXXXXSIASIVPIHSGGLDLQEECVYSTIQRRPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR55</accession>
    <name>A0A084WR55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Eukaryotic translation initiation factor 4e type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020958</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR55"/>
    <dbReference type="STRING" id="74873.A0A084WR55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020958-RA">
        <property type="protein sequence ID" value="ASIC020958-PA"/>
        <property type="gene ID" value="ASIC020958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020958"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012253"/>
    <dbReference type="OMA" id="THPIEYK"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="18807" checksum="6E0BB29ABB4E3846" modified="2014-10-29" version="1">MSNKYEIRPYASDSDDSGDEGADFDVDKLEPLEVGPGEHKLQYTYCLWFGKKGSHRAASGIKPMWEDPANMRGGKWVIRLKKSKIDRAWENVCMAMLGEQFLVGTEICGVVLCTQVSEDVLSVWNRTATDTDNTIRIRETLRRVLNLPQTHPIEYKPHCDSLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRQ9</accession>
    <name>A0A084WRQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00021182</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRQ9"/>
    <dbReference type="STRING" id="74873.A0A084WRQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021182-RA">
        <property type="protein sequence ID" value="ASIC021182-PA"/>
        <property type="gene ID" value="ASIC021182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021182"/>
    <dbReference type="OMA" id="HEKCTEF"/>
    <dbReference type="OrthoDB" id="6258998at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF7">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021182-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="321" mass="36263" checksum="E00D9743F235AAA6" modified="2014-10-29" version="1">MDVSSCNSTLPYTDGDDLIDSDHSISEDRTDDDEPPVREATPLPFHSKELPTPVNRSKKTPSKQVATPKTPVQPPEPRTEKSVDSGVLDPVTWILLAFVLFGCAYGVRNALQKYYTKLPPAAVIHEKCTEFYTLEESYTNIDDNLWDALEVSFRRANAHKRREPGTFLFLHHGSIEMVDRFIENISNITAYCFGGTEPIVLEQKYFQRADIQRDFGEFISQQKAALQKQGIMVVRNLEGIPPKAARAFHSICDPEEPLVDRAVIYFTMDTSKVGGKVTRGGVRSATEEAEMLLYHMWKDVLNPEVLDPLVIRLTEGVYRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRV3</accession>
    <name>A0A084WRV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021226</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026220">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525408">
        <property type="protein sequence ID" value="KFB52947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC021226-RA">
        <property type="protein sequence ID" value="ASIC021226-PA"/>
        <property type="gene ID" value="ASIC021226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021226"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="26275" checksum="0BE33A92CDAD766A" modified="2014-10-29" version="1">MPFSVGKEHSPGWHTVEFDHQLDIKRSASGSLSLHVAAAGCRNKQPAPDWTCGWNGYKIPVRKRAIKGGCNRQPGRERERTVIMRSYTCLVKTLRIKAQGSCELVRXXXXXXXGPFASAILVPVSRFGPVPVGQFSATPKPVPTPSFGQRPWFTDFRRTPLGGIGRHGWPVPVSAYTLPLGREDADVPTPLNLGEVAVLHWTHVAISVIRVMNGPGVWFVGFGLLAVAVSFRRSRRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS13</accession>
    <name>A0A084WS13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Lung seven transmembrane receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021301</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021301-RA">
        <property type="protein sequence ID" value="ASIC021301-PA"/>
        <property type="gene ID" value="ASIC021301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021301"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021301-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10401" checksum="3983EA47F3A64400" modified="2014-10-29" version="1">MVLPRPGCTPKPVSSSAAGLVSKREDVVSSGSDCKKTTPRTDSTSHEPASSMGRFACDRELKGGGQRKWPPKKEQFLARTSKMKAHTDQKQQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS97</accession>
    <name>A0A084WS97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002151-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00021383</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525413">
        <property type="protein sequence ID" value="KFB53091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS97"/>
    <dbReference type="STRING" id="74873.A0A084WS97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021383-RA">
        <property type="protein sequence ID" value="ASIC021383-PA"/>
        <property type="gene ID" value="ASIC021383"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021383"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012254"/>
    <dbReference type="OMA" id="GKWKNTG"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="110"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="404"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021383-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="474" mass="52383" checksum="7ABA699F244E37BC" modified="2014-10-29" version="1">MSSKRKPDGTKKAVKKRKNSESNYDSDLSDEYPRAGETSAREVVVEELRPMEKLPEELLGAYDKGPGKLLIAGMVSWEMTGKRDSKGVTKIRPNLYTFHRFTGETYRSMASFCSAAHSVLIDVNWKAWTFGRNQLSQLGHGDTTMCEKPTQVADLADFNVIQAACGRNHTLFLTDTGTVYACGDNKSGQCGVGNKLPTITSPTRISYNGPPIIKVGCGAEFSVILDIKGNLHTFGLPEYGQLGHNTDGRYFVNSTKMSFHFETQPRKVLVYMEKNKEGHVLPIENVNIIDFACGNNHTVAIDSKNRAYSWGFGGIGRLGHAEQKDEMVPRLIKFFDTQNRKVMRVFCGSSYSLAISDIGSLYLFGQNKKTGEANMYPKPVQDLAGWNITSIGTGYTSIVISADDSLIAWGASPTYGELGLGDLQKSSSTPKEVTRMEGMKIPMIALGYSHSLLLVNTEHEKTKEKYDNLPEFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT54</accession>
    <name>A0A084WT54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021716</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021716-RA">
        <property type="protein sequence ID" value="ASIC021716-PA"/>
        <property type="gene ID" value="ASIC021716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021716"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6127" checksum="1ABDEC5A5FD523F2" modified="2014-10-29" version="1">MSRSGKSRRSLGGGELVLGRQTCCGAVEGRSINSRKAIPRGHVEGRSAISLSSTGTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT68</accession>
    <name>A0A084WT68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Flavonoid 3'-monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021783</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021783-RA">
        <property type="protein sequence ID" value="ASIC021783-PA"/>
        <property type="gene ID" value="ASIC021783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021783"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6774" checksum="0396381EE676B52D" modified="2014-10-29" version="1">MALLWPPSGVAWRLNLLAIRVQLANYHFTSSSTASSTEIRSVAAHLDRNAASGANASEHGYMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUI2</accession>
    <name>A0A084WUI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">tRNA/rRNA methyltransferase SpoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022320</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022320-RA">
        <property type="protein sequence ID" value="ASIC022320-PA"/>
        <property type="gene ID" value="ASIC022320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022320"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11521" checksum="C37D2A3806AC3D60" modified="2014-10-29" version="1">MPEWDYDGTGRFSCEKRLIGQWSVTVRPGVSCVFPRDFPIETLASSRVMALDKRALGEFGARGFPFLAETVNPGMFDECNLISFRKLCNYDCIHHTFRNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUN5</accession>
    <name>A0A084WUN5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010848-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00022173</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUN5"/>
    <dbReference type="STRING" id="74873.A0A084WUN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022173-RA">
        <property type="protein sequence ID" value="ASIC022173-PA"/>
        <property type="gene ID" value="ASIC022173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022173"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024452"/>
    <dbReference type="OMA" id="FAYFPVM"/>
    <dbReference type="OrthoDB" id="8191482at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF224">
        <property type="entry name" value="CUTICULAR PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785424" evidence="3">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB53929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="335" mass="36778" checksum="921663361E3C454D" modified="2014-10-29" version="1">MTCCFFGGFLFWLSPGPLATCETNFSLGSLSRFIVWLAFLLVEELAFHRELMLATVATVATALHYGDEGIDVKINVEQNSNSYLSGRLPQGSFEYGLDVVKQKDNHFQHKVKGPDDVTYGCYGFVDPDGKPHLVHYVSDLKGYRIVPPESATKIYISRLERSINNVYQASQEKNVQWKDLFFPPACQQLYREQKVATTPRPTPRVFTTPRRPAPTQPRRVAPTITTTPAPVEPEPSSSNLCPSVVQVPPANLAPQPACSAVCDELKNELADIKSKLKTLLDAVAEKPSGKAGPKGKGNATFAYFPVMLSDGLPEGVDADSAKFAFPAVPQQCGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUS3</accession>
    <name>A0A084WUS3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00022216</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01027105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUS3"/>
    <dbReference type="STRING" id="74873.A0A084WUS3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022216-RA">
        <property type="protein sequence ID" value="ASIC022216-PA"/>
        <property type="gene ID" value="ASIC022216"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022216"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009121"/>
    <dbReference type="OMA" id="VMQYAKR"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000033">
        <property type="entry name" value="NEDD8-conjugating enzyme UBE2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022216-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="195" mass="21648" checksum="9149C64B8E293250" modified="2014-10-29" version="1">MITLARKKKESNSGGGGGNGGSATGPNGAGTLSDAPKRISIREFLLVKEVQELEQNLPTTCKVTFHDPNVLSEFTLVITPSEGFWCGGRFKFSVLVPEEYNMAPPKVKCLTKLWHPNISVDGDICLSLLRLNSIDGLGWAPTRRLKDVIWGLNSLFTDLLNFDDPLNIEAAEQYSKDKERFQAKVREYVSAYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUS7</accession>
    <name>A0A084WUS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP002639-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00022221</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01027119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUS7"/>
    <dbReference type="STRING" id="74873.A0A084WUS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022221-RA">
        <property type="protein sequence ID" value="ASIC022221-PA"/>
        <property type="gene ID" value="ASIC022221"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022221"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001063"/>
    <dbReference type="OMA" id="GFYFEFC"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF26">
        <property type="entry name" value="ODORANT RECEPTOR 10A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB53971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022221-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="419" mass="47735" checksum="AF4F86E9821B7CF0" modified="2014-10-29" version="1">MAVRKSVPVQVTSFANPEKLSDSEALYNFGLQRKIMLVCGIWPVEDSLERRWYLKSLIVINLVVLALCIVGEFLHGLNAYRDGNLNEVIESICPTVARISAFFRIVFYVANEKKIRRVLSDIDHAIRNQHPRERVITERVAYVGHCFTYCLILMMFFAALLYGVTPFLIMAYSWHQGQTPLVKLLPFKLALPYDSQDTLFFVLTTLFLNYASVPTITSQGSDALFSGVCLYVQGQLKGIKLDMEALATSEFGRSFGEDLLRADSLETRHVNRELRRISVRHQQIIELIDDVRTAFSPNVLLVYSGTALIICIVCIAMLIVEGLYKLTYLPYAVAELVLLFLCSYSGTIIRDSSEAIHTVAYNFPWYRYNRDTRHLIQMMMIRAQHGSNLDVPFFETSMATFSTIVRSASSYITLMKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAB2</accession>
    <name>A0A084VAB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00000590</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01003054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524109">
        <property type="protein sequence ID" value="KFB34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAB2"/>
    <dbReference type="STRING" id="74873.A0A084VAB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000590-RA">
        <property type="protein sequence ID" value="ASIC000590-PA"/>
        <property type="gene ID" value="ASIC000590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000590"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015373"/>
    <dbReference type="OMA" id="SLPHAYF"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF43">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="539"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="858" mass="97335" checksum="644AC795BF078232" modified="2014-10-29" version="1">MLSDADFHNEPSDTDDRRIGQPAMANGRSIRNLCDEDKIEVLQHVDAVEEMADGGETERFSGPGYGKQAVGVSVLEDRFQVGARESNQRPVGTNISFSQSFRRWSSNFGRSVKNNKRTVYNKTLRLMPSRIQKTFSIDGDLITTSVFDVDHITMELGQREQLMEDNPVAEQLRIEAIKSIAQKISTKRQIREHLAQTVHRRATTRAKSIGLLRRYRYSGKLYLARAAKLAKRFVTNFELFYGSMKQIEGHFGSRISAYFKFLRRLLVLNCVLLLFIVSFVTFPQLLAGHDDSVLPLRNGRLQFHLSDLITGEGYFTNSVLYYGSYSNQSFTLVPGTAEYSLPHAYFLTITLLVLATFVVISVSMGRSYRISFIESSATVQNLLTHKIVCSWDYGIANPKAARLKHASILHELRAYLDDRQREPPVEGRLLRLRSTALHALAHLIVLGLISAVAAALWALLVRFGETEHFSDWSALYVALVSNGTMLAFGYACQLLGRLEQYRQVSTQLNINLLRHFLLQTTIVGVLLAFWLTRKHSDGCWETAIGQELYRLIVVDFLVSTLLLTALRALRYVLHTRYGSIGPLDHLTPPPFCIETHSLRLVYNQTLLWFGVLFAPLLVSLVALKFLIVFYVNKFELIYLCQPPVRLWRSSQTQTLLLVLVFVSLFGVLLTHGYIIMQVPVSTGCGPFRGTEYMYQLFMQGILKLREEHLFWRIFVYVTKPAIIGGVLLTMGVAAYYLRAKSRAQIAKVRLLKELLGMEAKDKEFLLANLSKLTRGNDCPAEQLERIELLGAGGRLNGEQTDRYYIEQCATWRYEEAPPRKRTPPPTPSPQAAGSTDEVGGCSGYHRFEDDEQLRLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAF6</accession>
    <name>A0A084VAF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP010043-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01003492">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524146">
        <property type="protein sequence ID" value="KFB34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000692-RA">
        <property type="protein sequence ID" value="ASIC000692-PA"/>
        <property type="gene ID" value="ASIC000692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000692"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020996"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9580" checksum="0285BFCB68BD1E09" modified="2014-10-29" version="1">MEEQLDFRSATSLPRGLTDSDGDSVYQIGQASSPQQLSPRAGPAMRDYSRDGLFSPRAVSPESPPPGNGGPVFRTRNVPGRPMSPETDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAR9</accession>
    <name>A0A084VAR9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="5">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00000895</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01004187">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524195">
        <property type="protein sequence ID" value="KFB35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAR9"/>
    <dbReference type="STRING" id="74873.A0A084VAR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000895-RA">
        <property type="protein sequence ID" value="ASIC000895-PA"/>
        <property type="gene ID" value="ASIC000895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000895"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013954"/>
    <dbReference type="OMA" id="WKHQGQG"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000212">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="221" mass="25903" checksum="ABA23C1605BD3920" modified="2014-10-29" version="1">MVHYVKMEDGKVMPIQEMLKSIERYNPEHLKVIEEYVEEQARDNQYDLEANLACLKLYQFNPHLLNLDITYIILLKALTNFPHTDFVLCKCLLLPAQMNDETVKEIIYLADILEKCDFALFWTRLGKHPEYFKKINGFNDSIRKFVCHVVGITFQTIERGYLSRLLGNVEDNVLRAWLKRYGWKEEGGLVTIATQEDNIKTKHITEKIDFENLAPLMANCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBK1</accession>
    <name>A0A084VBK1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone-arginine methyltransferase CARMER</fullName>
            <ecNumber evidence="4">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00001787</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01007895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524442">
        <property type="protein sequence ID" value="KFB35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBK1"/>
    <dbReference type="STRING" id="74873.A0A084VBK1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001787-RA">
        <property type="protein sequence ID" value="ASIC001787-PA"/>
        <property type="gene ID" value="ASIC001787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001787"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010571"/>
    <dbReference type="OMA" id="YDPQGMT"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="19">
        <location>
            <begin position="268"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="520"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001787-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="645" mass="71494" checksum="5A7B94A573E03657" modified="2014-10-29" version="1">MSEQLARLQGCSVLAMDDGDKLVPKYDHKVTIVCGYDPQGMTLRIMKEGGGGGGQRQLEEFLVNGSDTTHLNRGNTAHLLIVGGELVLIRFASKADCGQFRALLQKISGKVNSVFNLRTEDSSASQYFQFYGYLSQQQNMMQDFVRTSTYQRAIYNNAPDFQNKVVLDVGAGSGILSFFAVQAGAAKVYAVEASNMAQYAQQLVSSNHLSDKIIVIAGKIEEIELPERVDVIISEPMGYMLYNERMLETYLHGKKWLKQPEGKMYPSRGDLHVAPFTDEALYMEQYNKANFWMQTEFHGVNLVALRDAAMKEYFRQPIVDTFDIRICMAKSVRHTTNFLTADEKDLHRIQIDVEFHILETGTCHGLAFWFDVEFGGSCAQIWLSTAPTEPLTHWYQVRCLLQTPIFVKQGQVLSGKVVLAANQRQSYDVEIDLKLEGTMISSSNTLDLKNPYFRYTGAPVPAPPGSNTTSPSEAYWSQLDAQGARNAVNLVNGITVNGLGEVDMSSTIINTNLMAIGGGGGGGSGNQPNIHPGLISSTGRLQSSSNVQQNQHHHQQQQQQQHQQHQQHQHQQHQQQQQQQSTTAQQLAMTPPIGCAATSTQNVAQHQLIGGAISPSLFTSPAQSILNSHLQNHHHGQPIHGNQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD65</accession>
    <name>A0A084VD65_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007377-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002862</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD65"/>
    <dbReference type="STRING" id="74873.A0A084VD65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002862-RA">
        <property type="protein sequence ID" value="ASIC002862-PA"/>
        <property type="gene ID" value="ASIC002862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002862"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000748"/>
    <dbReference type="OMA" id="LMAMAYE"/>
    <dbReference type="OrthoDB" id="6145499at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF25">
        <property type="entry name" value="METAL RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR-1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002862-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="776" mass="84579" checksum="99A5395A7C863FD6" modified="2014-10-29" version="1">MMNFALSSGHFDIDALERAIQQQVPQYFQTLAEENQLNPFDLVPLDGITLTDQDTVSSGIVLSPGAITPGLEESEQFLYGQNHLQSDEQQSSGSEGNSFCDINDNSILVEFEKIDDELEDGGCCNRSYSTVGNLRTHMKTHRGEYKFKCTEEGCSKAFLTSYSQKIHIRVHTKVKPYICSDSSCRKAFNTRYRLRAHERLHNGETFNCVVCEKVFTTLSDLKKHSRVHTQERPYKCKEDSCGKAFTASHHLKTHIRTHSGERPFACKISDCNKSFSTPHSLKTHSKTHERPKKKFSKNKLKKARPIASPQDQQPMSTNDAEPAADVVLCQAIETAPSNGQQFASGEAVNDDQMEMVPSASIEQSTAPPQETYSFVHVNDFHESKALELALATEEELNPQWIDISMLQTKPLAALNPVTSACLALPTSVPSYVDLAFNVNVADFLPSTDAAPQSGEPSTSASASSSAGTMLAADMVVASEDGTQVFATIDNYFDDNLLESANATVQIDRAIQKNSEQRGGSGVKQEEQEETDKLINELFADEFLPKLEPPPPPTGANFGQTVVDEAMRVLPPATVTKTLKDITADADICRCVNCQCDPLQGCIGGCGPENPCRSTVSQYAGNETLLPPAPESTHRLMQPTPQLHATNIQLISEPSGEATCVPSVDLVVSQKQPQPTQLPEPVKRPSTTSSCCRQQATPSTETESNGVASKLTDQLEPLTNMLKSLQHCSCAGPGDGHSKSCCVVICLKTLETLKKVLSTHSSLIQCHSSSNSSAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDB2</accession>
    <name>A0A084VDB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002977-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002921</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011205">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524652">
        <property type="protein sequence ID" value="KFB35956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002921-RA">
        <property type="protein sequence ID" value="ASIC002921-PA"/>
        <property type="gene ID" value="ASIC002921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002921"/>
    <dbReference type="OMA" id="HAHTGNC"/>
    <dbReference type="OrthoDB" id="6617264at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF1">
        <property type="entry name" value="FI03705P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783257" evidence="1">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002921-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="316" mass="36126" checksum="18547B9821DF715E" modified="2014-10-29" version="1">MVLLLLLGALLQQCGSSAGNATVVESTTKDGMREDPAPQKILSRKRRFLTFPEGSSFQVVYDQTIPMIGVERLFTIGITVALAYELPSITINQIEQMLQENAAEGYIFPKMDANVNQTVLVDTNVTPARKNIFSYYYQTPRPVVQAVPNAAGGGRINYYTASGGPDGNRRYDKYDRYGQRLSQWDRFVSSGLPRPPYVNPSGNDFGSIVNRYIQNWVRRHPPNYPVGKKRFYPVFGKRSIREDTDPLDRHFLNHHRVTRHALYERIEQFLTALPPTHETPNHHKHRLYDEAHAHTGNCAETYSYCEDSFWSSDFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE81</accession>
    <name>A0A084VE81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003394</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003394-RA">
        <property type="protein sequence ID" value="ASIC003394-PA"/>
        <property type="gene ID" value="ASIC003394"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003394"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003394-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7406" checksum="CB1DE9FE45D949CB" modified="2014-10-29" version="1">MRLTAGEPKPMEGSFSTAVEVPMLEKKGEAGSRGARGGLGYWHLRSRMATGKLLSGKLGERIYFRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFU5</accession>
    <name>A0A084VFU5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003907</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012468">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFU5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003907-RA">
        <property type="protein sequence ID" value="ASIC003907-PA"/>
        <property type="gene ID" value="ASIC003907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003907"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003907-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="15414" checksum="7D1A28F90607B0E8" modified="2014-10-29" version="1">MLMMLFRFRRQLLSTREQGSGKCLCRGWGVYVHRRWIRRLEGGEVAGTDTDNRIFNPSPSRLVLSPFELGLDSRRGWSVYTIDPRGTKENSSSIGLKSEATQERTWCVRLDCGCTSVSIFIFYLHLGASLLIHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFV9</accession>
    <name>A0A084VFV9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative colanic acid polymerase WcaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004027</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524800">
        <property type="protein sequence ID" value="KFB36853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004027-RA">
        <property type="protein sequence ID" value="ASIC004027-PA"/>
        <property type="gene ID" value="ASIC004027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004027"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004027-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="181" mass="20007" checksum="9305309551EFEB90" modified="2014-10-29" version="1">MSLSVSVKCGRQGECILTASGSCPSYCAPFSNSKCHTVARERLRLQCRGAVYGNEFDMTCTYVGRQMESRFPCTRVPPALRMCRFSGRKAQSRIECSPPPPPSPPLGTSGCSCEEISQNAYDLPQRKTTVRNDKAVARMMAKEVKGIPRVKGVAGEILKGSFCFRRRTKVCSPENEVEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG21</accession>
    <name>A0A084VG21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004086</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012602">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004086-RA">
        <property type="protein sequence ID" value="ASIC004086-PA"/>
        <property type="gene ID" value="ASIC004086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004086"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7407" checksum="6369260DE2B2257C" modified="2014-10-29" version="1">MHLPGIPPTPEVRAKPSGMIHQQRSLPVTASHFLIHEDSRSHDDCTVRGTTEAVAYVKYSILCAPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG71</accession>
    <name>A0A084VG71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP008813-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004135</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012687">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524808">
        <property type="protein sequence ID" value="KFB36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG71"/>
    <dbReference type="STRING" id="74873.A0A084VG71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004135-RA">
        <property type="protein sequence ID" value="ASIC004135-PA"/>
        <property type="gene ID" value="ASIC004135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004135"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="18358" checksum="2F50CB0577C124DE" modified="2014-10-29" version="1">MMFTILLVTGVAIVLTLSSIMAFRCRKKRNQPSVTINEYPLEDIRNRIPIVIPKEYEFSREKLCLLEKIGEGEFGIVRKATAQNILVTEPETVVAVKMVKTTCSPDVCDSLVSELQMLIHVGQHLNVVNFLGAVPMNACSSEYRVAIMPEVNRSSVKLFASQGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG80</accession>
    <name>A0A084VG80_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00004145</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01012696">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524808">
        <property type="protein sequence ID" value="KFB36974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VG80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004145-RA">
        <property type="protein sequence ID" value="ASIC004145-PA"/>
        <property type="gene ID" value="ASIC004145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004145"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001226"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007684"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013480"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015608"/>
    <dbReference type="OMA" id="THENNVN"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16213">
        <property type="entry name" value="EFh_PI-PLC21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000084">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF149">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="13">
        <location>
            <begin position="639"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="758"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="554"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="992"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1069"/>
        </location>
    </feature>
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        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB36974.1"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004145-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1377" mass="152720" checksum="5B6B8F6532CCA9DF" modified="2014-10-29" version="1">MVKSRLWRAFTNPAEVVNVYLIGLQGQIGRRARLRVCLGFEDSCIGTPVTLRVDVKGFFLYWVDQNHEMDMLDIATIRDVRTGQYAKKPRDIKLRQIVTMGSQDTLEEKTVTVCYGADFVNVNFINFCCTRKEIARLWCDELIRMAYNLTQLNGPAIMFLQKAYTKLCLQVDKTGKIPVKNIIKTFATNKDDRRRVEKALDVSGLPSGKGDTLALAKFQFEDFFNLYKNLSQRTEVEKVYDELVGTSKRRLMSTSQLVDFLNKTQRDPRLNEILHPYANTARARDLIQEYEPNKFNAQKGQLSFDGFLRYLMSEDNPIMAATKLDLTDDMDQPMAHYFINSSHNTYLTGHQLTGKSSVEIYRQSLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEICAKDVLEAIAETAFKTSEFPVILSFENHCNPRQQAKIANYCREIFGDMLLDRPLDSHPLESNVELPPPALLKRKIIIKNKKKHHHHHHHHHKKAATVEAPVRPPLNTTKASGVVGHLAIDELRFSSITEILSLMECTFVQRSVRAFVGANIPWSVRDGKKPTAYKSHCRSALPPPTGNGDIPHHAPPLQQIRQSSKESTGSSDTDSDDESDDESMPGAVAGPIGATEADKVQQTKETEAGAEISALVNYVQPVHFSSFENSEKKARFYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNYQTLDLAMQLNLGIFEYNHRCGYLLKPEFMRRKDRRLDPFAESTVDGIIAGTVMVTVISGQFLTDKKVGTYVEVDMFGLPADTVRKKFRTKIVRDNGINPVYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHLTLRTEVGQPIPLATLFLCIVVKDYVPDGLSDFAEALANPIKYQSEQEKRSKQLAVLQEDMEPTEEDSCVNKKSETVKSSGESNANSSSPAKARQVGGTQSSAAGSGGGGGGAADNDGDREAPLEAITKMVSLPVAQSSSQDHSMSPSARSNTTQFTLSGGGGGGGGGGGGGPIITTTTNTSGMGSSDTANHQHDGGKIVADPLEKIFEDKVIRKKREALEKELKALKKSHDKEKLKIHASQKSTDLGVDGPVKKSKFAMGNKLVKRFSSKNMADMNVKVPPCAPSSDAGDVAGDAQAERLRQICRDHASSYRDVLEKYHEIIYTLAEDLLRQSQEAQMKQLKTQQERETSEVMRQLQLSRKSEVKQLAMVHKDKDELERMKREVDSTLVEKGVTERTRLTATYERKRDELQRQHDAVKQGLEDHKVKARSMLEKEAESHACISDTFLAHLNTSNSTTSCSSVGAAGTTHPPATSLSSGNICATGGGGGGGGAGTHENNVNNAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGD2</accession>
    <name>A0A084VGD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP013252-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00004220</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012844">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012845">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524818">
        <property type="protein sequence ID" value="KFB37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGD2"/>
    <dbReference type="STRING" id="74873.A0A084VGD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004220-RA">
        <property type="protein sequence ID" value="ASIC004220-PA"/>
        <property type="gene ID" value="ASIC004220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004220"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005031"/>
    <dbReference type="OMA" id="HWPWHTA"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783345" evidence="13">
        <location>
            <begin position="20"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="316"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="589" mass="65102" checksum="21A2A4AF058D5A18" modified="2014-10-29" version="1">MRGFFVALLVATVMFLASADQLSCGERKVKTVYLVQHGIETKEGHWPWHTAIYHREGKEFHYACGGSIVDRNTILTAAHCLFNDRGALVKLDELSVQVGRNQLSEASLSSQEHAPLELIVHPAHNRNSVANDIALIKLATEITMTNYIQPVCLWNMEPDLALIAGKNGTVVGFGLTEHDRVSDYLRQAQIGVVDTWTCIESDRAVYGNSLTSNMFCGGGRKGVSACNGDSGGGMFFELADTWYVRGIVSFMPLRENVGLCDGTKYTVFTDVAKYRDWIEEYISPTSAAVPTDPLLVDNSPKLRLLNFNTCGISANLTGSSNDSFLANPWIGLVEVIPRGQNRTQALCHVTLISEWYVLGPAHCFANDGHVRTIRLGDYDTSTETDCVERQGKTVCAPPLQRLPIQTIDIRPDYNALSITDDIALVQLAQPADMTQPNVRPICLPVTLAQRSYKPKSFTLAGFPTGDDGTVVAQSNPTFLNSVNCQQRFNEIGFPLRKSYTQTCANGLPANHTGPCTRIMSGAPLQTVQTFGRRERRFLQGILSFGSRECDPTVPDIYTNVASYLEWILYNMKDIKLNAPDTRDRLVFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHQ3</accession>
    <name>A0A084VHQ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004719</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013199">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHQ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004719-RA">
        <property type="protein sequence ID" value="ASIC004719-PA"/>
        <property type="gene ID" value="ASIC004719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004719"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="16749" checksum="E19B80D6BFB42B39" modified="2014-10-29" version="1">MADELGITKNVAMCEARAGKRKIQNDGLITSIPSTLSTLNNQPGTLGLTHSKNPQLTFLSARASGCCSKTSWPVESYAPSNWTRTQQHQAAASAGGEHSFSSDKTKAQRDAQVEANYGKSSSSSVEEGILLLRRLAFSGRSERNGETGTLFVLLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VID2</accession>
    <name>A0A084VID2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005037</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VID2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005037-RA">
        <property type="protein sequence ID" value="ASIC005037-PA"/>
        <property type="gene ID" value="ASIC005037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012284"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="218" mass="24459" checksum="9DCA22EECD4F3902" modified="2014-10-29" version="1">MRHVKKDYEACATLYQSTMAKLGQAAATTTTTSTTFHPVGPTMATHPAAALRSGQYNAGHDVSQQRHHHHHQHDHAGYNGHPNSTKSVEDAEEERLKTVCCAFQKYMQCSEFTVRHACGDETALFTRKFLDKMSNTLMRRLVDQFRSMEFLINHLRTSSNGSTFRANVIVYGIAIPNTKVDNRERSSYNEPAYITTILSLTMMTISDQKLNNGTAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VII5</accession>
    <name>A0A084VII5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005096</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013359">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VII5"/>
    <dbReference type="STRING" id="74873.A0A084VII5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005096-RA">
        <property type="protein sequence ID" value="ASIC005096-PA"/>
        <property type="gene ID" value="ASIC005096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005096"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006464"/>
    <dbReference type="OMA" id="AHCKKGQ"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000184">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16785" checksum="D5E5ADD0F1859AF3" modified="2014-10-29" version="1">MAKAPKEKISAVQVFGRKKTATAVAYCKRGKGLLRVNGRPLEQVEPKMLRYKLQEPMLLLGKEKFAGVDIRIRVNGGGHVAQIYAIRQAISKALVSFYQKYVDEASRKELKDILTQYDRTLLVADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIM8</accession>
    <name>A0A084VIM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004990</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004990-RA">
        <property type="protein sequence ID" value="ASIC004990-PA"/>
        <property type="gene ID" value="ASIC004990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004990"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="16954" checksum="8359E8859CD4118A" modified="2014-10-29" version="1">MVQATNTKSFASSVARPNWRSFPNEKSVPSSNELFYESSSTSLHNIGIHTFGKGVLRMKPNGIPSRLDTNHHPYDLYDRAPATESDVDRHELVPSAGRKLPTVCLPQAGGSFWKIRSDSGDDSSPSDELARPITSWTSAPIRFGDHSLCCCCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIQ2</accession>
    <name>A0A084VIQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP000621-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00005219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIQ2"/>
    <dbReference type="STRING" id="74873.A0A084VIQ2"/>
    <dbReference type="MEROPS" id="M14.A18"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005219-RA">
        <property type="protein sequence ID" value="ASIC005219-PA"/>
        <property type="gene ID" value="ASIC005219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005219"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013935"/>
    <dbReference type="OMA" id="IGHITEY"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000005">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783433" evidence="13">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="149"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KFB37846.1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="444" mass="49763" checksum="8E735371F89D562F" modified="2014-10-29" version="1">MPINLPAGVLVLVVALVLADGHRLPSPKGLDVQNGADKPRAEQSATPQPVKYDGAQLWRIAYDDQPKKNAVAELQDRFDASMWNYNATSIDIFVAKQKLQQAECFLRSANIPFEVVIEDIQRAIDTENPSLEETELWENRNGHRMTWTAYHRLEDIYDWLEYLAKTYPDLCSTKSIGKSVQGRELKVLRISNGNPANKAIWMDGGIHAREWISPATVTFIANNLVEDWDNQPEYLRNVDWYILPVHNPDGYEYSHQYDRLWRKNRGGLQYGPCAGVDLNRNYGYKWGGQGTSKQPCSEIYAGSGPFSEPETKAVSQFMESSAANWKGFLTFHSYGQYILYPWGYDRVVPPDHAELRRVGDAAAQRMLQGSGSSYTVGPSGSTLYPAAGGSDDWARGALSIKYAYTVELRDTGRYGFVLPASQIQPTGEEAVAFVDTIAQEVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM06</accession>
    <name>A0A084VM06_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006707</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC006707-RA">
        <property type="protein sequence ID" value="ASIC006707-PA"/>
        <property type="gene ID" value="ASIC006707"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006707"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010402"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006707-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="10348" checksum="8AB59C4009E3030C" modified="2014-10-29" version="1">MMVKAREINKISQIIQMQENWNMTTKGSIKDRLTQSNARETTMAKKANIRTGNRVNSEHDEQNRPQTSWSAESPFAQQLGSNRLVGRKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMM6</accession>
    <name>A0A084VMM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Discoidin domain receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00006562</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014607">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014611">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMM6"/>
    <dbReference type="STRING" id="74873.A0A084VMM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006562-RA">
        <property type="protein sequence ID" value="ASIC006562-PA"/>
        <property type="gene ID" value="ASIC006562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006562"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001873"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018360"/>
    <dbReference type="OMA" id="KWLRWKN"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05051">
        <property type="entry name" value="PTKc_DDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1190:FF:000003">
        <property type="entry name" value="Discoidin domain-containing receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000053">
        <property type="entry name" value="Epithelial discoidin domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF580">
        <property type="entry name" value="DISCOIDIN DOMAIN RECEPTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="561"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="853" mass="96807" checksum="AC08A14A908E7C0B" modified="2014-10-29" version="1">MVSRGLKEYLQIDLLKMHVITAIKTQGRFGKGQGREYTEAYALEYWRPGFTKWKRWKNTRDNEILSGNINTYSEVEQALQPIIFASKIRIYPYSLYDRTVCLRAEIIGCEWDEGLLSYSIPKGVIRGVEVDLSDRTYDGEEEGDRLVRGLGQLVDGQKGADNFRIDIHGYGKGYDWVGWRNDSLGWAGKPVEMVFEFDSVRNFSSMVLHTNNMFSKDVQVFVHAKVFFSIGGQHFTGEPVQFSYMPDTVMENARDVTIKLHHRVGRYVQIHLYFALRWIMLSEISFNSAPVTGNFSDEEVNGNSISQENSVEYPLQRDESGINIVNKGERNHVTQIISPKPIDQEPEPHFIGVVIAVLTTIILLLIVIIMFIVAKNRRTRTAAVLDALQHNLHTDSLGIDKRLNSNFKVSIDDNESIDKSSLYHEPFNVNMYTSAASGCSMNDMQRHHITPDYTDVPDIVCQEYAVPHMQDLIPKIPGGYVSVRLTPPTLNNIFPKPPPVPPPPEKYYAATAICKSSTTPTTPSNQQQQQQQQQQLNAYSDLDLGISDDDLQLSEYPRDKLVIVEKLGCGVFGELHLCETKGYSSSLVAVSTLRPGASEHMKKEFRSKAKQLSRLSDPNIVKLLGACLKDEPICIVLDYKYSTDLNQFLQEHTAETGSLVQHNSLSYGCLIYIATQIASGMKYLEQMNVVHRDLATRSCLVGPQLEIKICTLGTVINRIAYPADYCHLEGAGRQSQPMPIRWMAWESVLMGKFTSKSDVWSFAVTLWEILTFAREQPFENLSDDKVIENIGHMYQDNKKHILLPIPVGCPREIFDLMCECWQRNEASRPNFREIHLFLQRKNLGYRPSASSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMT3</accession>
    <name>A0A084VMT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006629</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006629-RA">
        <property type="protein sequence ID" value="ASIC006629-PA"/>
        <property type="gene ID" value="ASIC006629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006629"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006629-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10379" checksum="755FAA70678E91F0" modified="2014-10-29" version="1">MSPGGDGAVLNGINTRATLRRCWSERYASGPYRMLTESERFKCCLARCKVINVILLLLTASMKAIMVMGGKPCPVRVRLNTLEQLQNRPPEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNZ8</accession>
    <name>A0A084VNZ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00007183</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNZ8"/>
    <dbReference type="STRING" id="74873.A0A084VNZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007183-RA">
        <property type="protein sequence ID" value="ASIC007183-PA"/>
        <property type="gene ID" value="ASIC007183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007183"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007106"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001328">
        <property type="entry name" value="Ribosome biogenesis protein WDR12 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007183-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="428" mass="47933" checksum="636EFF34DAB1CB2D" modified="2014-10-29" version="1">MSLSITGATEGQLQIHLFTKQKQYAVPDVPYSIRANVGNKELNVLLNTLLNDAGYKSTEKVEFDFLLNGEFVKIPLGQHLKEREISFEDTVDLEYVERYPAPEPQDCLLHDDWVSAVQAKDDWILTGSYDNTLNLWNTKGKHTLTIPGHVAPVKGVAWISLDNQTGVFASASHDQNVMLWEWNVVANSVECVHVCKGHERGVGCVAVNPSKTQMATGSMDTMLKIWSTDVQGDKIEPSASKKAKLEQENVRTPISTLAGHREFVSGVQWMDNSTIVTSSWDHTLKIWDLSLGGIKTEFTGNKSFFDLSYSPLNGMIVTASPDKNLRLYDPRSKYATFVKNTYLGHTQWVQTCRWSTTNEYLFVSGAYDNHVKLWDYRSPKAPIYELIGHEDKVLACDWSNPKYILSGGSDNAVRVFKSKISGSASNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ51</accession>
    <name>A0A084VQ51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007626</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007626-RA">
        <property type="protein sequence ID" value="ASIC007626-PA"/>
        <property type="gene ID" value="ASIC007626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007626"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9546" checksum="554E8023C70E91C2" modified="2014-10-29" version="1">MTKYPLLLPTQLLLGRRAFERVQLKLDLHFSQQRVYRMKDLITIPHHTAELELPVVLAIVTETALSLSSSSGGIYPAGPDANYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQL5</accession>
    <name>A0A084VQL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013135-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525004">
        <property type="protein sequence ID" value="KFB40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VQL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007722-RA">
        <property type="protein sequence ID" value="ASIC007722-PA"/>
        <property type="gene ID" value="ASIC007722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007722"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005472"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="169" mass="18194" checksum="5573E083069124A0" modified="2014-10-29" version="1">MADLLAVKMFARGIPTCPINLSTLRPRLPDLGNWSLPHICKEAVISSNGTTPEGASGNYSSNITATADAFYQPPPPGSLHAAAAAAPGAPGKRPSPYSRRPSSTTTRPICTSSTRRTRRCRXXXXXXXRPSVAAEGGAVVCRPHRYLRIDHINMRLYREVSVSMIGYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR86</accession>
    <name>A0A084VR86_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP002315-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007967</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015530">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525019">
        <property type="protein sequence ID" value="KFB40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR86"/>
    <dbReference type="STRING" id="74873.A0A084VR86"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007967-RA">
        <property type="protein sequence ID" value="ASIC007967-PA"/>
        <property type="gene ID" value="ASIC007967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007967"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010622"/>
    <dbReference type="OMA" id="YCFADLI"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007967-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="340" mass="38326" checksum="C12B82FE064228FB" modified="2014-10-29" version="1">MAMKQENWRDIIADRLRERNKTETSRYADIIHYNNRLFDTAVKLRQENLDLKIDKKIRDSAGAVGTGVAGTGFNADVAAITNAQIQALEKKVLAQQEELTELHKRKGEHSQMVINLNQKLGELQRLLGEKERALAEQTALCVALKDELEEMKTSHVTIKDESLASQLRANTAEDKLRMVQDENQKLLNLLMEYKSRDAEIMNKENDKFLKEKKARIESELERAIRDIPGPSTLGPDLDRFDFDGLPEGVEFKFDAHDGEVNAVRWSPIERIVATGGADRKVKLWDVGKGVCEQRGVLVGSNQGINSVEFDTTGSMILAASNDSASRMWSVVDHRLRKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRU0</accession>
    <name>A0A084VRU0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00008303</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01015779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRU0"/>
    <dbReference type="STRING" id="74873.A0A084VRU0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008303-RA">
        <property type="protein sequence ID" value="ASIC008303-PA"/>
        <property type="gene ID" value="ASIC008303"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008303"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012938"/>
    <dbReference type="OMA" id="GCVTDFE"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06618">
        <property type="entry name" value="PKc_MKK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000623">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase hemipterous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="147"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="820"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1053"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1106"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB40684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008303-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1161" mass="125277" checksum="91025BCB6A6518B3" modified="2014-10-29" version="1">MQPTDGSDDDVGSTTNGDVGRRANNKDEQRSNNGVGEGSGFAMSTSSIDTRITMMERLIQKPTPRTPPPPTLALPGSSTPGANRFNRTGSGGMGGGSGPNRPTLDLHLPIQTGTRRSESELKFQKIVDKSGLLKINEKIYRTQLADLEDLGELGNGTSGHVVKMRHNPSGAIIAVKQMRRTGNDEENKRIIMDLDVVLKSENCKYIVKCLGCFITDADVWICMELMTTCFDKLQKKSKKPVPEEILGKVTVATVRALAYLKDNHRVIHRDVKPSNILIDDRGNIKLCDFGISGRLVDSNARTRSAGCAAYMAPERIDPAKTVYDIRADVWSLGITLVELATGVFPYRGCVTDFEVLTQVLTSKPPRLPEDQNFSPEFRDFVQLCLRKDYQERPKYPDLLRHAFLQRAEHDANINVGEWFRNVAVSCGIQLTSTPSQMASHTNVNNTSVASSPGPWVGSSEQTRIPTPLGSLTEAVQAQSNQQKQTIAIAASSIPIKSTGSGPATVAAVPSPHLAHEAPSSFHTSRQQQHSQQQQQQQQILQSKLSNIQLASAAVTASGAPTTAMPPAASTSSSYASTSSSPAPAFDPRRSPSPQAQHYLSKMQPPKSAITSTSNAIPIGGPELAPRKYKHSPFLSRRTASEYGNGSPKKESTLSSLGQSIFKNLTTSPFSQRKSLPAGESKLTVSSASPVASGSLYGTSPLPESPFLVHSNGAGSNPSSPLLLLRKAQHHDPSTETDTQYKHLQGNTSPIVLQRFYHQQNQLMEQQREALQHQQPQPIYGNHPQQFGAPGAGPVVYTTVANVQQPGSGTMRYSPLPSHRTVHHGVHPVLTSNLPPQSHYPHHHEPPPPPPPSGIPVYQQQHHAPSGTASPKHHRTSGGSSFFSTFSRGMKSASRGDKVIDRGGVGGSASVAPAPTTMYGATTANQALPYHQHHYSGATNNSVLNRHGSLMSNGAGTDGLKEQQEQGLAKRSFASIKLNLGNNNNNGTSGTSTLGDKRTLKEKHLLQQQLQQQQQHQPYPATHFDPSVAGSTGPGAGVPPPYGSGMFVSSMVQPPSAIPSHAGPISHVLGSGTADRRHRSPDPPPRLNRGQSPLLLQRKLEQLGHAGSPLLNRRPFNSTSPSPPLPPRRGSESVPGSPQHLRTRINYTPEPHRRPYRTTIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT74</accession>
    <name>A0A084VT74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001606-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT74"/>
    <dbReference type="STRING" id="74873.A0A084VT74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008729-RA">
        <property type="protein sequence ID" value="ASIC008729-PA"/>
        <property type="gene ID" value="ASIC008729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008729"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014326"/>
    <dbReference type="OMA" id="TDCNVML"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="676"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB41168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008729-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1250" mass="133862" checksum="FCF834B401E4A587" modified="2014-10-29" version="1">MASGKYNFAIDRGGTFTDVLCITPDGTVRTLKLLSEDPANYPDAPTEGIRRILQQETGRALTPDGLIDTGLIGWVRMGTTVATNALLERAGDPVALVVNRGFRDLLQIGNQARPNIFQLHELRVGSIAREMGFQHVTLSHEAMPMCRLVARGFTACAEAYLTPHVERYLDGFRAGFRDQLRGAEVLFMQSDGGLTRMENFRGARAILSGPAGGVVGYAVTGVRDAAGEDDQDALVETPPLIGFDMGGTSTDVSRYAGSYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPLTVTDANLILGRLLPEYFPAIFGPDENEHLDYNASRSAFEALREEINEHLATDEAGTGPLTLDEVAMGYVRVANEAMCRPIRALTQARGYDTARHVLACFGGAGGQHACAIARQLGMRRVVIHKYAGILSAYGMALADVVHEAQAPCGLELCPDNRAALKERLHALSACCVEQLESQGFSLANDGITLEPYLHLRYEGTDCALMCTPDRVVENADHTVYGFGDFGRTFRERYRSEFGFVLEGRRILVEDIRVRGCGRTTLFDEPEIPAATGPIYAEKTTVAYFEGVGRQVTPVYDCAKLRYGHTIDGPAIVIDRLSTIVIEPGSQANVTRRGDLVIEVDALLDESSGGGRRVVDERLDAVQLSIFNHRFMSIAEQMGRVLQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQLRVRGGTLKPGDVLLSNHPQAGGSHLPDLTVITPVFAGTDDQRPVFFVASRGHHADIGGITPGSMPPHSTSLDQEGAAFKSFLLVDGGVFQEAAIVQRLTTPSPTSGAPGTRNLSDNLSDLRAQIAANQKGIQLVSELINAYGLSVVQAYMGHMQANAELAVRDMLKAIARETLARTGRTVLEAEEHMDDGTPIRLTVQIDADRGSAVCDFTGTGSEVAGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIEVRVPPGSILDPSEGAAVVGGNVLTSQRVVDTVFAAFGTCAASQGCMNNVTIGDEGWGYYETVAGGSGAGPGWHGTGGVHTHMTNTRITDPEILELRYPIILRRFTLRDDASGGRGRWRGGEGVHRELLFRKPLMLSVLTERRTLRPYGMAGGGPGKAGLNLLLRVGDSNDSTRPVNIGAKAAIQVRAGDVFSMKTPGGGGYGAPEDEEEPVRGVVTLATDGDNHPLAPSSKAFVERGSVYEYRMAQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT80</accession>
    <name>A0A084VT80_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15 16">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 15 16">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00008735</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 16">Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 16">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 15 16"/>
    <dbReference type="EMBL" id="ATLV01016271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT80"/>
    <dbReference type="STRING" id="74873.A0A084VT80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008735-RA">
        <property type="protein sequence ID" value="ASIC008735-PA"/>
        <property type="gene ID" value="ASIC008735"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008735"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008071"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000080">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="18">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="17">
        <location>
            <begin position="194"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008735-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="383" mass="42448" checksum="ABB55498707B93F3" modified="2014-10-29" version="1">MAISVTCIAPVNIAIVKYCKHWSGGKRDDDLILPINDSISVTLSTDHLRTKTTITASPELTKNVLRLNGVEESFENPRIQRCLLEVQKKAKSSGKCPKPEMLEWKIRVESENNFPTAAGLASSAAGYACFVYTLATLYGIEDEELSGIARMGSGSACRSLHSGYVQWVMGEREDGADSLAVQVAPATAWPNMHVLILVVNDRKKATASTQGMSTSVKTSELLKHRAEKCVPQRIEQLKKAIAEHDFETFGRIAMTDSNQFHGVCLDTYPPCFYMNDVSRQIVRLVHEINNMAGFIKVAYSFDAGPNACLFLLEKDVVEVSAIVRRAFPFNHCQEADYYKGIPNDEAAMAAVPEKVLNTFSVEEPNQLRYIIHTKVGEGPRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU44</accession>
    <name>A0A084VU44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009082</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525098">
        <property type="protein sequence ID" value="KFB41488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009082-RA">
        <property type="protein sequence ID" value="ASIC009082-PA"/>
        <property type="gene ID" value="ASIC009082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009082"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="20631" checksum="B55A1DE1DF4DAFF7" modified="2014-10-29" version="1">MAMAVEETVLCRFRRRTEIGSDHRSDLCDTGKDRKVRPTNEAESVSDFLPITCLHEVWLVGTTGVEYGWRRHTGFRVSGIKKAAGWFGSQEHHHHHHHHDSSLKSILRGARLRHRRRLIVGKLAGNCAFLVRECKPCRRCAISRRRHRRLSSAFEDLDDDVIGCMVIAVRWLDGDENEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUG2</accession>
    <name>A0A084VUG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009227</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01016788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525113">
        <property type="protein sequence ID" value="KFB41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUG2"/>
    <dbReference type="STRING" id="74873.A0A084VUG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009227-RA">
        <property type="protein sequence ID" value="ASIC009227-PA"/>
        <property type="gene ID" value="ASIC009227"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009227"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004562"/>
    <dbReference type="OMA" id="GFARWAN"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000208">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009227-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="24919" checksum="9E9ED1969E4E6274" modified="2014-10-29" version="1">MPTPTLYYFPMSPPARAVLLLLKEVGLTVNLKEVSPVAGETRTEEFMRINPEHTILALDDNGFFLGESRAILTYLVDAYRPGHSLYPNIPKEKALINRVLHYDLGTFNAKFGSSFGGLFGGAQTEITEENRATAHKALTDLENYLVRNDFFAGENPTVADLSLLPMIATAVHCGLDLTKYKRLNEWYENCRQLKGYEDDQEAARQVGEFLRSKFPEGLQALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUW3</accession>
    <name>A0A084VUW3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009390</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525143">
        <property type="protein sequence ID" value="KFB41757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUW3"/>
    <dbReference type="STRING" id="74873.A0A084VUW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009390-RA">
        <property type="protein sequence ID" value="ASIC009390-PA"/>
        <property type="gene ID" value="ASIC009390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009390"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008135"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020533"/>
    <dbReference type="OMA" id="WQNSAGW"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000023">
        <property type="entry name" value="CSON002431 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000032">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="399" mass="43862" checksum="BB425C9C9E0CE310" modified="2014-10-29" version="1">MFPTVRVSFSGPLRQITPADRYVVLLDVVPVDNRRYRYAYHRSAWLVAGKADPPPPARLYAHPDTPLGADALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLARLGPGQSIPITPKELADVDHKTYVFPETIFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRTTCPSFTNLLDQSFSSMVRDPMDALLLEQHLRSPLRLFPDPLMAQFATGPGHDLQDPSSAALLEKARQHLQMWGRSPYSELLLPQMYQRPQNLGALNLGLWQNSAGWATAHQLPPGFIAAAAAAAGGPRSTPPPNQPPPTLGPSATVSSAPNAAPMTPTSSSGSSPSPDPRAKHFTRFTPYQIPQASHHHPQPQPLHLQHPPSHMPAAPPPHPSPSSPRSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUY9</accession>
    <name>A0A084VUY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003354-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009439</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525156">
        <property type="protein sequence ID" value="KFB41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUY9"/>
    <dbReference type="STRING" id="74873.A0A084VUY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009439-RA">
        <property type="protein sequence ID" value="ASIC009439-PA"/>
        <property type="gene ID" value="ASIC009439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009439"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014590"/>
    <dbReference type="OMA" id="QLVQPWY"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25093" checksum="82FA458C0FA35764" modified="2014-10-29" version="1">MSMGTMECVCQLGNSTSKAKKIDVTDEYKKIILDEHNKYRSTVATGGVKWLPKAKQMVTMSWDDELAQLAQLNANRCTQKHDQCHNTANFRYSGQNLNHIKTFGAGDDIGNIPQVIKDLISSWWDERKDVNSRMVDSMYDPGRHTMIFHFAVMAAEKANKIGCALSQWSDEGNPFLYLVCNYSFTDIVGLPMYQRGAPCSGCTKGCNSDYAGLCNADEPVTYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVV2</accession>
    <name>A0A084VVV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009756</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009756-RA">
        <property type="protein sequence ID" value="ASIC009756-PA"/>
        <property type="gene ID" value="ASIC009756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009756"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009756-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="17909" checksum="159C10A869F267D1" modified="2014-10-29" version="1">MHAASANIQGRQSGAVLLQPCRHMLICKRVFEPLPSGDVYLAYLKLIIPFPSVSDMSIEASRRLWIYYQTVLGTNYAPTFATITIVDPSTSGATCSGPSSFRIVPRCGYEIIFSFLILPGPGLVRNEAPGRSPICAQILTMLARGRTFSGTRVCVCVHYPGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW51</accession>
    <name>A0A084VW51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009866</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017442">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525168">
        <property type="protein sequence ID" value="KFB42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009866-RA">
        <property type="protein sequence ID" value="ASIC009866-PA"/>
        <property type="gene ID" value="ASIC009866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009866"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009866-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12174" checksum="4654026D1864EE63" modified="2014-10-29" version="1">MEPCPNCWWSFTSPWGCYRQLVPAESNQQPNVQLQTPVGGRVSIERGSSVVMLQMGAKNQVPFSPSSEKRARGTVMRGVPLCAPSKERPVRESDAVLEASKDDVENARQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW91</accession>
    <name>A0A084VW91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009912-RA">
        <property type="protein sequence ID" value="ASIC009912-PA"/>
        <property type="gene ID" value="ASIC009912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009912"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783952" evidence="2">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6431" checksum="F2CDE4C93AC1846A" modified="2014-10-29" version="1">MIVGAFVLPLTISGITLASTTRSPRTPRTRKRESTTASGSPSGPILAVPTGWYSDIDISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW92</accession>
    <name>A0A084VW92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003785-PE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009913</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW92"/>
    <dbReference type="STRING" id="74873.A0A084VW92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009913-RA">
        <property type="protein sequence ID" value="ASIC009913-PA"/>
        <property type="gene ID" value="ASIC009913"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009913"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014521"/>
    <dbReference type="OMA" id="SANNAMQ"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009913-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="530" mass="58121" checksum="A5BDAA7906B3027C" modified="2014-10-29" version="1">MEALMSGQCASQSLGPANQLFGLLVQTILAAQCTISPPDMWPKDYGPTALAQGLDEYDFVIVGAGSAGSVVANRLSENPEWKVLLLEAGGDPPIESEIPFMFLSLQHTHYDWIYNAASTKARACRASTNGCYWPRGKMLGGSGAMNVMVYMRGNARDYDGWEARGNPGWGWKTALRYFRKSEDNRDPQIVRDGKYHGTGGYLTVVTSKGDTAGMQRMLQAAEEAGFPVQTDFNANKHIGFGRMQRTIVNATRCSPSKAFLVPAKQRPNLQVIKSVLVTKIEFDETKRVSAVQFRYSSGEIRSAKVKREAIVSAGTANTPQLLMLSGIGREKDLSPYNIPVVSDLPVGRKMQDHVAVPMVFKLNRDVTANSSLPKSTVEYLLHRAGPLAEEGLTGLVGFVNTFNRHDPYPNIQFHHLYGPARSGQTNAYLNAAEINETIQRVPAMANAKSDLVLVLAILLKPKSWGSVRLQSSNPQDKPKIEAGYLYDQDDVRALIGAIRVQQRLWSTRAASAFKPELLKLGSSGVRATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWF3</accession>
    <name>A0A084VWF3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DnaJ homolog subfamily C member 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009981</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWF3"/>
    <dbReference type="STRING" id="74873.A0A084VWF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009981-RA">
        <property type="protein sequence ID" value="ASIC009981-PA"/>
        <property type="gene ID" value="ASIC009981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009981"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006313"/>
    <dbReference type="OMA" id="DTCGEEF"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009981-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="578" mass="65887" checksum="4C72B216D3A6577D" modified="2014-10-29" version="1">MKCHYEVLGLPRTADGEEIKKSYRKLALRWHPDKNLDNPEEANQQFLLVQAAYDVLSDPQERAWYDNHREQILRGGHTDYEDNSLDVFPYFTASCYKGYGDDPGGFYAVYAEVFDKLAAEEVEFLDTEDEYETIPKFGNGQSDYETVVRLFYGFWEGFCTKKSYAWLNPHNVAEIRDRRILKAIEKENKKVQQKARKERNEEIRSLVLFVKKRDKRVQAYKKLLEDRATQNRLKSQQNRLEQIRRQQLEIEEQQRNSSNLFDQAYEEQLRKKLEAETTDDESDDDVDYAGGDSNGLEDAMAGLIVGQNENGEESFYVDDLYCVACDKMFTNRSSFENHESSKKHKQNVEQLRKAMREESQEFDQPEETVPPEQEESNVLPNDEQEPDDIALNGSEIEQEPNEKPTKSKQKKNKNKKKTLNNVSVIKSSDDEDPTSGLPQDIDMVGLRLGKKGAIDSDDDDDWGSGSKKPARKGKGKATTSGQKAKGQPNGPATKAPESDQKPVDTPAPKKGTQKTSETPLSDEDGPQQTDHSCVTCKEKFSSKNKLFDHLKKTGHSVYIDKLKESKAAASGKGKRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYY9</accession>
    <name>A0A084VYY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010958</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYY9"/>
    <dbReference type="STRING" id="74873.A0A084VYY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010958-RA">
        <property type="protein sequence ID" value="ASIC010958-PA"/>
        <property type="gene ID" value="ASIC010958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010958"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016107"/>
    <dbReference type="OMA" id="IHMNKVM"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000148">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="4">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="422" mass="47393" checksum="11C4EF54A276E55B" modified="2014-10-29" version="1">MGGVEEHIFNLSQCLLARGHKVIIVTHSYGDRKGIRHMTNGLKVYYIPIKVFYNQVVLPTMICNVPLIRYILLREQIEIVHGHSAFSTLAHETMNVAQLLGLRSVFTDHSLFGFADLSAVVTNKFLEISLANCNHCICVSHTVNVVVVSRLVYRKGIDLLAGILPKLKHLPNVHFIIGGDGPKRALLEEIRERNNIQDRVVMLGALEHAKVRDVLVQGHIFLNTSLTEAYCMAIVEAAACGLQVVSTRVGGIPEVLPSSLIILTEPTVDSVYRGLREAIAREMEKKQITSSRYMNGSIDGLTPTPSKTTYSGMCAFERNQIVANLYNWNNVTERTEKVYKTALREAPSSLDSMMKNCLRSGVWPFVLVISLCHLILRFLDWFVPRKYIDLCCPENPFLNTDSVRQPSDSVASTVRRKREKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ97</accession>
    <name>A0A084VZ97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011076</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011076-RA">
        <property type="protein sequence ID" value="ASIC011076-PA"/>
        <property type="gene ID" value="ASIC011076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011076"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9920" checksum="043AC4843D2FE484" modified="2014-10-29" version="1">MNSAAHLGSDPSGERYIEATVAWNEKKNGGAFYHHVSPCWKVIERGHLRTSRVADAAIQDRDLVHPKDWLGTTNSARFRYEGVVAKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZA6</accession>
    <name>A0A084VZA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011086</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018626">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011086-RA">
        <property type="protein sequence ID" value="ASIC011086-PA"/>
        <property type="gene ID" value="ASIC011086"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011086"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011086-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7688" checksum="AAF29A61F6FEE8FF" modified="2014-10-29" version="1">MLKELLPRKAEQQYRPMKRNGIAIQGVGKVAISRPFDHPPSGFIFPGKQRSNTPPGKTLVTMKKRFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZP4</accession>
    <name>A0A084VZP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002707-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011242</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525253">
        <property type="protein sequence ID" value="KFB43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC011242-PA"/>
        <property type="gene ID" value="ASIC011242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011242"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019538"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011242-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="192" mass="20548" checksum="8B548F851BC7DDCD" modified="2014-10-29" version="1">MSSSSPSTPSASSTNPSTPSSEWSEPPLSPTLPVTPSQMAAMRRPSSLAVSAESLLIQNVTSPVTDATTRPHHESMAKQGTPVGSVTTTYAMASGTRTITTASEGSSRGSTETSEEQYDGSKHTTFRPLIIPTLPDVRRSRVVHSMPYQSKHHHERHWGPFFEEPVNVTSGAALPVGYHLSTEAMLNCRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZS7</accession>
    <name>A0A084VZS7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4 gamma 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00011274</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. Interacts with DAZAP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC011274-RA">
        <property type="protein sequence ID" value="ASIC011274-PA"/>
        <property type="gene ID" value="ASIC011274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011274"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022443"/>
    <dbReference type="OMA" id="SAKIRQH"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000064">
        <property type="entry name" value="Translation initiation factor 4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
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    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="eIF5C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="983"/>
            <end position="1106"/>
        </location>
    </feature>
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            <begin position="1156"/>
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        </location>
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    </feature>
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            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="431"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="465"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
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        </location>
    </feature>
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            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037759"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00040449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011274-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
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        </source>
    </evidence>
    <sequence length="1338" mass="150555" checksum="9262A4A2A29D5415" modified="2014-10-29" version="1">MVKPSLGDTIQSATKAVHNHRQTTAVQQQWNLRENSSQFASFTIPGKIEKIAVPPSVGLRSAYPTAGASPTFKTEDPRQTGTESRATGRENPVPPASRRWVPPSLRPQHGLTEEARIDSIFRKVRGILNKLTPEKFQKLSDELLKLDLNSSKILNGVILLIFDKALDEPKYSSMYAQLCKRIEKELETDIDKNKSSTFLQILLNVCRDKFENRVQYSEKIINSESTLTDDLEEKKNVAKQKILGNVKFIGELYKLDMLAEPHLHKMLRSLFTNKSSSSTEKNCEDMECLAQLIRTCGKNLDTELGKQLMDQYFDRMEQYSLSSKFPPRIRFMLRDLIELRKNNWTPRKVALVEGPAPIQELNHDDDVLPPGLNHLRNRDRDYRNNDRSEQRDWISKFTLNLQHLNDGFNLLGVSSPSPLLPSYNQSSNGYGNRDHRDNGGGGGGNYRMHNNRNNQNNYGNNNMRYNKHSNNHHHHQGGGGGGGGGSMRDSSSGSHNSPYGNSNMMNNKDLAPRFKRNLMTPPQNPVEELQMRPTPNSLLFKANMNIKTQLPISSPMGVGGVGGGSKMSYNSQSLNEFASPLTTRTLLSEQRNASQINSSAFSGGSNAGSSFDGSGNSGSSAMSNSNANNNQNSNNAAGNNSNVMSSGRNAGGISNVNQNASSNALSHHHQQQQQQQNMSHGINPRSIAGTGMNANNYHNNQLQHNQKHQYHHEDSQQHYYTQQHEHHGGHQQQRGYGVINGGSERSPMPHDGHSHNNRHYDSHSMTTSNVMSTTGPNTPASPASNLIQNEQMIVKQSSSEKLEKKNKKDKGPGKDEYLVRVAAFVSDVMLENIKQQIAKAEQQPHNIEEKGSSKETASNNDKNKTAQEIVIEVVDKQSNNNSPTTTEQEAGSEDKRRESLSESSSSLPDSSSLIDTAKLETGLESQEMQDFKAQQLEANETTADELGMEEKVDVGSETNKETNAVPSADQEQVEENTFEQCPPIVQEGSPSAEECRKPSLMEELVVAFGALKIPEKFMRDAIIKILNEILDRNEPFHAKTIEFLQVLRKEAKLSNSAVLESFKSVVNGISEKEKTIPKITTIIASLLARAVSVNLCKLTDISSYTDNGQHYPLFLLVLQHLHKQLGKPVLQEMFNKSKVNLMSSLPECDRNKERMAEILEDRNLSFLYPLLRVQSELWKQILLDDNPQHFYKWIKENVEAICYTDPGFITAVMTVLLKYISQESNKLEEERKRVEKEKEIFTKYCPVLHAFLHSNIDLQLIAIYAIQVYWYDIGYPKGVLLRWFQEMYEMSVIEEDAFLRYKEDVTDTYPGKGKALFQVNQWLTWLAEAEDEDDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0L7</accession>
    <name>A0A084W0L7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00011499</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084W0L7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011499-RA">
        <property type="protein sequence ID" value="ASIC011499-PA"/>
        <property type="gene ID" value="ASIC011499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011499"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009774"/>
    <dbReference type="OMA" id="HDANEDQ"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="722"/>
            <end position="736"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB43761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="807" mass="87746" checksum="00051DD1F89DB70B" modified="2014-10-29" version="1">MLITTSLNQKQFIDSLCTNEAEDSSYDSDCEGEDISHEQVSRTTSDTLGQEFAEYVSSGGGGTGGGSSHHPHGTVDVSPTTTALPEHSPGYQQRVEFALKLGYTERLVQAALQRLGPNPAQNELLAELIKLGSQPGAKCANEFTVDHHHHHHHHGLGESGGGLGTDGGSASTAPGTGAGMASEESLRPIVIDGSNVAMSHGNKEVFSCRGIRLCVDWFKNRGHKDITVFVPKWRKESSRPDNPVKDGEILNELEKERMLVFTPSRLVGGKRMVCYDDRYILKLAADNDGVVVSNDNYRDLVQESSEFKKVVEERVLMYSFVNDRFMPPDDPLGRSGPTLDNFLRVQPRKGDPPPPCPYGKKCTYGNKCKFYHPERGSLPHKSVTERLSEYAARHLQARSGLEGGAGGSGRCAVQGKSLSVPLSNSSSETSPINDKRKALCRTRSNIPSESSNSSSLAYGGGINLGTPPMPSDPMMLPPHQGQHPAVRPPQQLPFLAPPGAVASNRPLPWDQQHHLHQPHGGMDVQQIFPKSHSIENISKEPYVHHAAAGLHHAGCYGTQAAMWPRGHQPSAAQQQASQGGAGGGGAGGLVSQTAPSSLDQSDPNGLAAHDGVNLHRKLHRQLTLNPAGCDPRIYQMQRMQQQSSQQQPGSPQQQQQQQQQQQSSHAAGAPQLSPHRPLAPSLSGGSRPSPPTQWELHQHVQRIASAPDSVRPWGHNGPPPASSSEPHINLGWSSNPAGAPANNHSQQQQQQQQQQHHQQQQHDRRRLHYHLASIFPEEQVQTVMQMYPEETDAQTICAAILTMFKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0M3</accession>
    <name>A0A084W0M3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011506</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01019123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0M3"/>
    <dbReference type="STRING" id="74873.A0A084W0M3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011506-RA">
        <property type="protein sequence ID" value="ASIC011506-PA"/>
        <property type="gene ID" value="ASIC011506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011506"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013400"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="360585at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="146"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="471" mass="54099" checksum="5E964B996B137F2E" modified="2014-10-29" version="1">MCFRLLQNPTRNFVRGYRHYRIKDLSTNNCKPGDKVNVKGWVKSIRKMKGNLFVDVNDGSDPTNFQLVVNKEKHIDTAYGSSIEASGTLVASPKNQFELQVDSLTEIGKCPLAEGFPFYPKKTYPPEYIRNHLHLRSRVSSMCSTFRLRHEATKAFNDYLAKDGFVQIHTPILTSNDCEGAGEAFLVKPSNEKLLKSMMKDGVPVEQAYFDRATFLTVSGQLHLEAMAHGLDKVYTFGPTFRAENCKSNIHLSEFYMLELEEAFMDSLEELADRVEDMVKHVTKCLLEKSAADLRLVRKLTTEQPLEEAFDWTEKPFPRMNYDEAIRVLKANQSKLKSPVDALEGINKEQELFLIDYCRSPVFVCYWPKNIKSFYMRENKQNGQLVDALDLLVPHVGELVGGSVREDNYDRLQHKLPNLELLQWYLDLRKFGGVTTAGFGLGFERYLSWLLNVHNIKDVIPFPRWAHNCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0S7</accession>
    <name>A0A084W0S7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP006014-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00011665</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0S7"/>
    <dbReference type="STRING" id="74873.A0A084W0S7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011665-RA">
        <property type="protein sequence ID" value="ASIC011665-PA"/>
        <property type="gene ID" value="ASIC011665"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011665"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011213"/>
    <dbReference type="OMA" id="VAWFGEE"/>
    <dbReference type="OrthoDB" id="9998363at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000616">
        <property type="entry name" value="PR domain zinc finger protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011665-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="451" mass="50018" checksum="CD975D0B5F8F3715" modified="2014-10-29" version="1">MYPSATFAPQAGTEGSPPFVGRKCRPRVDMHLNLSPEPMSDGYEGYGELSSQSSSSAPAVRQPVSPRHGSSVCALGFLPVDSVSKGYPPEEVCLRAAHSTVASGAARVTTIRKSSSTGLLTTNEAASGMKNSNWIRSIRLANDVRSFNALLELTSTQLLRIRLTGDVNSGEELKLWFAEDVIAHMQIPFLTPVNIQRQNCYVCHLCQKSYEDPNPLKIHLATSCNREPVAILWHRLHQALAARYGPFNPLFEFQPWRHSAFRPVLNPHVVKLDHLSGPPSPAHRHVHPPPTEPVAADEPTGAHLVTAAHLETIVSNMGSSKQGHVCIYCGKLYSRKYGLKIHIRTHTGFKPLKCQYCLRPFGDPSNLNKHIRLHRQHDGSLYECGLCGKKLARRRDLQRHLQARHNSTQMLDQSTTSEDDDDDDDDAVEEGEGDGRSSARRRDAVHNAHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0W5</accession>
    <name>A0A084W0W5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011709</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01019161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0W5"/>
    <dbReference type="STRING" id="74873.A0A084W0W5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011709-RA">
        <property type="protein sequence ID" value="ASIC011709-PA"/>
        <property type="gene ID" value="ASIC011709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011709"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001982"/>
    <dbReference type="OMA" id="YNCVTGN"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000639">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="39"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="400"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011709-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="538" mass="62145" checksum="7C1C69D5733CB87A" modified="2014-10-29" version="1">MVLRATVETSHNNELTMTEERKITTTPVMEFYRDKCVLITGGTGFIGRLLIEKLLRINVRQIILLSRPKKGKTVQERCDDLFGSVVFMNLKKDCPTFVERVKLVDADLQHPSLGLSEESIEYIVNNAQIVLHAASDVRFDQALKKAIEVNVRGTRDLLRIAEKIVNLELFVYISTAYSNCPQAVIKEQFYTPPSDPEKMIQLVEAMDERFEEHMNKTVNEFIHPWPNTYVYTKALTEDIVRQYGELLPLAVVRPSIVIATNEEPISGWTDNIYGLNGVIAGVALGIIRIMHVDDKNKADIIPADIVVNAVLAAGWETYVERKLDRPLPVAKSNGELKGAEKPRTKIYNCVTGNDNPISYEKIYEYSIEVGKHCPPKKSLWIVCHNTTQNKYLYEFYKLLYHLLPAFLIDTYLRAIRRTPRIMDLYRKVHKFATVIAYFANGKWAFENENMKNLRERLTPDDQIMFPCNIKKIEWTDYFWTYIHGLRKHIANEPLENLNEAIKRHKQMRIVHFFILVAYYSLLALLAFYLCKAVGMLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1U3</accession>
    <name>A0A084W1U3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008943-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00012096</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1U3"/>
    <dbReference type="STRING" id="74873.A0A084W1U3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012096-RA">
        <property type="protein sequence ID" value="ASIC012096-PA"/>
        <property type="gene ID" value="ASIC012096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012096"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011188"/>
    <dbReference type="OMA" id="IPYIVHW"/>
    <dbReference type="OrthoDB" id="6234674at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002166">
        <property type="entry name" value="Protein borderless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000830">
        <property type="entry name" value="Turtle, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001149">
        <property type="entry name" value="Turtle, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001842">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="249"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="344"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="437"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="551"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="684" mass="77768" checksum="48784D4A838FA72E" modified="2014-10-29" version="1">MPDGAGAVARVVGSVAHVSSLLALLTLFGAIGHNAGFLADRKPVYLEAKIGSYVVLDCPVDFPQDIPIPYVLHWNKENKPVFTLYDGLLNAYETFIGRVTLLNNDIVYGKASLNLTSIRESDNGWYECKVIFPNRVPNKRNNGTWFHISVLGGTLLRVPPINQTVLEGDPAFFHCVVQNQETMFVEWYKDGVSLLEYFDLSHRSTMGPDGSLTINPTQMSDLGFFTCEVRNAANDTQAASAYLNVQYKAKVVYAPKEVYLPFGESAVLDCHFRSNPPLKNLRWEKDGFLFDPYNVQGVFYNRNGSLQFDKVDDSHAGRYSCTPYNDLGTDGASPIITVIVQRPPYFTLKPKLVYVTKMGGTVEMHCDARDRDGYHTPDIMWVKKDGSLLPHGRYTIQGGNLTITDIVESDRGIYGCQATNEAATVTADAEIMIENVSPRAPYNLTGNSTDTAITIRWAPGYIRQYLEYIIWYRLADAPEWRTLKVSNKHILEATITNLQPAREYEFMVLCQDNYGDGMFSKAFRYFTKPTEYEQPENGLQDALLQFSQIGSPRNFFVRKEQEHFLAQWEPPELGLDQLRFYILRWWVEPKHVLHGSRETSETQLILDDLDEDEMYTFQVFALSTTNYTSGSNEFEIYVYPYRRVKAMTIGGALILLLCLAIICTLLFLKRKRMRKLREAENVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2D8</accession>
    <name>A0A084W2D8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012325</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2D8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012325-RA">
        <property type="protein sequence ID" value="ASIC012325-PA"/>
        <property type="gene ID" value="ASIC012325"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012325"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012325-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="17701" checksum="55EAD693AC2B81F3" modified="2014-10-29" version="1">MQFRGYYLFSPCLARCIRQHQPTSQPTGYSSNQTCTIYYNRDDEEHREDRDHDHDHRRTNTQPKHTSNQPPRPLHTDHYHTQLCRQGAMPLEVTALMFSLHSSPPKHPTARSGADLTNLRPPGSHSLPSCQSLAPSFRPLRSNGIREPMLMMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Z7</accession>
    <name>A0A084W2Z7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012476</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Z7"/>
    <dbReference type="STRING" id="74873.A0A084W2Z7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012476-RA">
        <property type="protein sequence ID" value="ASIC012476-PA"/>
        <property type="gene ID" value="ASIC012476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012476"/>
    <dbReference type="OMA" id="MNTEHNK"/>
    <dbReference type="OrthoDB" id="10030453at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018792">
        <property type="entry name" value="NUPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17149">
        <property type="entry name" value="NUCLEAR PROTEIN 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17149:SF4">
        <property type="entry name" value="RH17958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10195">
        <property type="entry name" value="Phospho_p8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012476-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7180" checksum="0C21C7B4DD0EDFCE" modified="2014-10-29" version="1">MSDDYDQYDMELEKHIHSGHSGKQRSKKEASDHTNHYDPSGHSRKIVTKLKNTEQNKKSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W416</accession>
    <name>A0A084W416_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00012952</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W416"/>
    <dbReference type="STRING" id="74873.A0A084W416"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012952-RA">
        <property type="protein sequence ID" value="ASIC012952-PA"/>
        <property type="gene ID" value="ASIC012952"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012952"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013169"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022497"/>
    <dbReference type="OMA" id="KWNAGLQ"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19008">
        <property type="entry name" value="LGIC_ECD_GABAR_RDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000033">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784457" description="Gamma-aminobutyric acid receptor subunit beta" evidence="20">
        <location>
            <begin position="35"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="269"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="444"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012952-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="557" mass="61300" checksum="ABE9B30592355205" modified="2014-10-29" version="1">MSLTIEVPHAKSPSLGVLILTLNLALFLPQTINRTPPYVLAGTGGGSMLGDVNISAILDSFSVGYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRIHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWKDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVSLGVTTVLTMTTLMSSTNAALPKISYVKSIDIYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQAADANHPPPPPPVASDHSHGHGHGHSHTHQHTPKQQMGSRSGTMSNVPPNMGSRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTINGGRGGGQPGGGGGGPPGGPPGGGGGGGPDEESAAPQHLIHPGKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5C7</accession>
    <name>A0A084W5C7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013352</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5C7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013352-RA">
        <property type="protein sequence ID" value="ASIC013352-PA"/>
        <property type="gene ID" value="ASIC013352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013352"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019408"/>
    <dbReference type="OMA" id="EESMPDF"/>
    <dbReference type="OrthoDB" id="7789165at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF0">
        <property type="entry name" value="DAEDALUS ON 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784300" evidence="1">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="212" mass="25402" checksum="3BEF82BF2021C655" modified="2014-10-29" version="1">MERDSVWAILSLSIVLLLQLSDVSCVKEKRIPVKISDPVVFTDEPKPFTVRVTKFICVETPYEESELLQCRTVLRRNRPTFFNISVHVPGVLNRIYFQVRTYYRYNSYEPFPITLLMEICSYFRKPTTDIFSRHLMSIMMEVVSHLLYQCPHGNTTYDAVYWLEDKFFPQSMPAGDFRQDVWFRTEHNRTIFAYQAYFSVRRMGIWRSMLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6D9</accession>
    <name>A0A084W6D9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006857-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00013759</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6D9"/>
    <dbReference type="STRING" id="74873.A0A084W6D9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013759-RA">
        <property type="protein sequence ID" value="ASIC013759-PA"/>
        <property type="gene ID" value="ASIC013759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013759"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011465"/>
    <dbReference type="OMA" id="SAHEYRD"/>
    <dbReference type="OrthoDB" id="7737922at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784415" evidence="4">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB45783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14668" checksum="F198D7FED7DC0AD5" modified="2014-10-29" version="1">MMKITIATLALLAVAVFGYEHEHHDYHSHPSYKFEYGVKDPHTGDHKSQWEHRDGDVVKGAYTLHEADGTERVVEYSSDKHNGFQAHVKRVGHAHHPEVYGHHEGGHSYGGHGHGHANSYANGNLYNHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6W6</accession>
    <name>A0A084W6W6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Bnr1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013925</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020996">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6W6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013925-RA">
        <property type="protein sequence ID" value="ASIC013925-PA"/>
        <property type="gene ID" value="ASIC013925"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013925"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013925-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8762" checksum="AF56C598C584312A" modified="2014-10-29" version="1">MGREKGKPKKVVSYFWQTRKQSVASTAVRRAVVMLCDLYSRSHHGSNHIWAEGSEYCSSKIRNAFTLRHALACYLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W796</accession>
    <name>A0A084W796_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00014066</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01021178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W796"/>
    <dbReference type="STRING" id="74873.A0A084W796"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014066-RA">
        <property type="protein sequence ID" value="ASIC014066-PA"/>
        <property type="gene ID" value="ASIC014066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014066"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023540"/>
    <dbReference type="OMA" id="FGQHARK"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="282"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB46090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014066-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="675" mass="76808" checksum="E7D03BA32F071279" modified="2014-10-29" version="1">MSFRMLTTRLYKHGRLLVQSYFKRDLHISNVWNSPTESVKVNTINETLRHDLRISEFRNNSFLRFGNQARRLFIDNVLNRVTNPYSVDLRLQATKKLLYGDSTPFFALVGVSLASGDGVLTKNDELEAVCWEIRHAMSNFQQKVGEKDIESRLDEEFGVENLNIGPPIATGCSAVVYAASLKEPTATEQDDAGIYNPNHFSSSGVVSPSSNEGSDVLEHWKSTDNLLFPERSPSMALQQMANWGNREANKPTLKNRKVRFNSETRTRTMSESNTYTQHQTHEEPTKEANDGQNFSIEEYPLALKMMFNYDIQSNAMAILKAMYRETVPAKRRTVESSWEKSLMEKTNFLPPHPNIVEMYGVFCDQVPDLSMSTTLYPMALPQRLNPEGFGRNMSLFLLMKRYSINLRDYLEQNNLDMRTRILLFAQLLEAIAHLNRHGVAHRDIKSDNILIELRPNMPPTLVLTDFGCCIADKRHGLRIPYTSDEIDKGGNVALMAPEIIGQQAGSFAMLNYTKADLWACGAIAYEIFGGTNPFYSGENSMLKNTTYEEEMLPPMNQNVPRLIQCLVQNILQKNPNKRLSPDVAANVVQLFLWSPSVWLREGFTPSSNEILQWLLSLTTKILCEGPLRVTPDDTMGRRTYTEYLLIASFLTRARLERIKRALAWIHTVNADTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W828</accession>
    <name>A0A084W828_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC750617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014364</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W828"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014364-RA">
        <property type="protein sequence ID" value="ASIC014364-PA"/>
        <property type="gene ID" value="ASIC014364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014364"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012164"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13611" checksum="80413B0067E8E106" modified="2014-10-29" version="1">MYKQGRLFGFGRPIEATLAVVWYAIVIWPGSGEKERYMGRPLDEEEIDPTDGQRSESDMERTTAPPPRCTVDDNDDVTDGGPYQLELNVHVRKMDIYADDASVDLRKCIHYLYVLPSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W874</accession>
    <name>A0A084W874_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014416</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W874"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014416-RA">
        <property type="protein sequence ID" value="ASIC014416-PA"/>
        <property type="gene ID" value="ASIC014416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014416"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013222"/>
    <dbReference type="OMA" id="FANVDEY"/>
    <dbReference type="OrthoDB" id="10399071at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="597" mass="64606" checksum="254194A7429CAB8C" modified="2014-10-29" version="1">MSASSRFFLSLCSEKRIFATDTDAVRCGAISKTFAQEGSNRPFPVQKCTASGRPVTNVRRSAQLRGCYNRLVQSNGRIETVLDRRLLAGQRSAAALLPGNDERSRGVTGGGEALPFPDFGIPGPVANSAKVQSIANFIKTDFANVDEYGVDLTSDFKDLATIRDIMYSISQEVATAGEAIGTAFAALATSTGPSIDTVFGTATSAITSMEALLSQSFTDEFATLEAIIGTYVTTEFRDSFGEMGIALANLRLALGRLKPGIEQAKVASKNSATIAPAIINKYVTPKMIQDVQDTLQRTRSNIQVITYTVTNTLGKLEIADDFIIEITDKVATDITEVETEFENYSTTTLTAVGESSDGAAAALQAGYATETDAIALIQSELDASTDFTDNFAPELTKVDDVLGTQALAALTLDITDAVTAYLDLVGAVDDDVSAFFSDEGCQPVLALVHVLIDNGYYATFCFEKYSPFAFNMFADFVDLVGDCYANELVKFDYLYEAVDPLVQLILFDVEDLAEALTTCVGYPDSSHCFSMIAPLYDKLFALTTAKRDYLKELFMHETDSSVQRFSACYHAQKFSIRQIMHELLANIDACETDGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8C3</accession>
    <name>A0A084W8C3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP011103-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00014452</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021410">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8C3"/>
    <dbReference type="STRING" id="74873.A0A084W8C3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014452-RA">
        <property type="protein sequence ID" value="ASIC014452-PA"/>
        <property type="gene ID" value="ASIC014452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014452"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021829"/>
    <dbReference type="OMA" id="TGWTMEN"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="555" mass="63390" checksum="2CB6DCDD24E79EE6" modified="2014-10-29" version="1">MKNIAREYLASSSCHGMPYVVHPKLSIVERVCWSVMVVMSLCVCIAAIVIGHQKWNEKPILVSFSPTQIPIWQIPFPAITVCPQTRVDVESFNVTDVYRRARQANHTLTEDEWRKLRVLTHVCSAVMRPKQDFYGADTGTNGSRQQPGEDEHVVQQLINMSIPTDERFMSCMWSFNYHPCKRFWARKVTENGICYSFNMLSSAELYTVDQEFREQEVNPNMGGLYKYHASNIRSTGWTMENGYTDTEDLLAYPRRTASAGFKGGVIMLVKTHEQNREYVCSGSLQGYKITIHAPDEIPRLSEYHIRVPPMQAVSIIVKPRMLTTQKSLHRFSPSKRQCYFSDERTLRFFRVYNEQNCEFECLTNYTLETCGCVTFAMPRLNSTRVCGAHEMKCYESAVMRLMELEEMNTDADQELCDCLPACTTLKYDVELSNDDLNLKALLDSIVKDESGLQGNDLMLLYVYYKDNKFIYTERVEYMSFTSELANFGGTLALLAGMSLTSFAEIVYYLAVRPVCLWSSSWYGKAKVGGNGADRTPESSPRSGAHSVLPVRPWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8K7</accession>
    <name>A0A084W8K7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nocturnin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014586</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021488">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8K7"/>
    <dbReference type="STRING" id="74873.A0A084W8K7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014586-RA">
        <property type="protein sequence ID" value="ASIC014586-PA"/>
        <property type="gene ID" value="ASIC014586"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014586"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023313"/>
    <dbReference type="OMA" id="CALFFDR"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09096">
        <property type="entry name" value="Deadenylase_nocturnin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034965">
        <property type="entry name" value="Deadenylase_nocturnin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="5">
        <location>
            <begin position="112"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014586-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="449" mass="49962" checksum="FA48111168C38480" modified="2014-10-29" version="1">MNGALKKSHLQRVMLQRMGSFTSAPQIKNVDYQDDKLEITEGMSVSDLVEYCRIARGDDRPQLVKRKFLKPIDRLNGSDLTDGFKMLKLDSISKTLGMHNDGFVRCPMEALTWDCRRYQLVEEIVQNDPDIICLQEVDHFKFLQKILSAQGYEGVFFPKPDSPCLYINGNNGPDGCAVFYKKDRLEMVNHFTRILEVWRVQSNQVAIAAVLRTRDTNQELCVTTTHLKARKGALLSKLRNEQGKDLLYFIDGIAGNRPVILCGDFNAEPIEPIYSTVLNYKPLGLGSAYADLLASEEEANGGGNVTNVSSQDENNQNAANLRPHSSGAGSRSGSIGSAHSVGDECGLSNGVKTKAELSATYEPAYTTWKIREEGEVCHTIDYVFYSKDKLTVKNCLMFPSGEEIGVDRTPSFLYPSDHFSLLCDIELKPPTESIQTVATSSTQPPNHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9A7</accession>
    <name>A0A084W9A7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011969-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014807</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021667">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9A7"/>
    <dbReference type="STRING" id="74873.A0A084W9A7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014807-RA">
        <property type="protein sequence ID" value="ASIC014807-PA"/>
        <property type="gene ID" value="ASIC014807"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014807"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005201"/>
    <dbReference type="OMA" id="PQRYFPI"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014807-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="497" mass="54561" checksum="B34151ED3981554A" modified="2014-10-29" version="1">MPEEQIPLDDHRPASSASSTSRSRQPSFGDVQDNGAPERIPVVDGDGGHFVAIRNMLNASRNRPVARIAPLLEPSFVPAPQRYFPIVIPAEPTIEELLRHAAGTEDLATVREIKLKVISHMTSLQRIPCFIPHLRSLILEGSIVMTLRDLGCDMTTLRYLNVSRCSLKHLDGTTGLESLEELVADYNLIEEVGPCTNLTNIKKISLKGNRITDLGSVTFLALCEKLEALDLRENLVSENPSFRHVLKLNIPQLRSLNEIPFREVAGDDTDLSSSEYRSSSSGSVEDIHRGRWNMLGTTVADLQREAAGIERRPTTASVERRVTVELLDQERPSTAGKSGPQRGSVCRPLTLCPSVPDPVKIKAQLTSGEPVVGSIVTKARRRRRQKTAWGESTSCSSVSSSDSSFSKDFPDRLPQKAVDLELGVIGVVAGEGDAGQGHSQSRSGAQPPNPSGAGADDDPQSLLRAARLWRQRSLQTRETIREQEQQLLMLRQLNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9D6</accession>
    <name>A0A084W9D6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002274-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014832</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9D6"/>
    <dbReference type="STRING" id="74873.A0A084W9D6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014832-RA">
        <property type="protein sequence ID" value="ASIC014832-PA"/>
        <property type="gene ID" value="ASIC014832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010628"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="642" mass="67896" checksum="AFFA888620273753" modified="2014-10-29" version="1">MQLAETQNFRYPYEDRLEDIKEEDTDFEVGSSRIGSIKDSFSSTPDYDLLAKRMASREHDDISMSSLQEFENLEHVISLENRKMQQGSQDSLSNGSFTRRFVQRGVHGDDISLSSLKEFEGLENACIEAHLIEIKAKEEAALLLSRSDESNKSDRSNGAKRSPPTTTVGPLSGGGKSDATGASTTHVVTTSSNASATVLGDPSERTVGVKVEKRTSSSDVSRDSLSGTTTTTTVTTISHESQVRQVLDEEDTSSHLVLTVSSDSLDGSKAPKVPPPPARDTLPSAHSSSDSLEINNRNVDVMTSSIDSIEFSKTGIATTRSSQSDSIEHMLGQQQPHRSDSTDSIEAQLHQKLLQQQQTGASKSRTLSDAKRDSLESLACSSDNQSGFSSPTKSAHGTQRVIGPDGSGVGYSQHTIMHTQAIHSTSTSIGGPMQKDISADSLTGPDAAFLTSTESLETSSTATNATYQNETDSQMSSSVTSCDSITMVDTLGPLHGSAMGMGDFDVFGSSATGGFGGSTMTSSISAAAAASATYSSTSGSFSSSSFTTTSTSATSVSSSSSQQQQVFRSSHMGAAVSSSSTVTAAVSSSSSTLASAYRVQQQQMMGDIELLSSEMFPGDIAFDEVKETAKERLHSKSTEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9E3</accession>
    <name>A0A084W9E3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01021721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021722">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9E3"/>
    <dbReference type="STRING" id="74873.A0A084W9E3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014840-RA">
        <property type="protein sequence ID" value="ASIC014840-PA"/>
        <property type="gene ID" value="ASIC014840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014840"/>
    <dbReference type="OMA" id="PINGDIN"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF118">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="15404" checksum="09EBB0B7543434E8" modified="2014-10-29" version="1">MDSGLAMTKLPDPQVGSIAEAYAGRSIFITGATGFMGKIMVEKLLRDCGDIRCIYLLIRPKKGVDPAQRKDEYVKNLVFEQVREKYSDRLEKIRLIRGDILSQGLGLSEADHRELVENTINRVIDWAFMQSERAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9E7</accession>
    <name>A0A084W9E7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021724">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9E7"/>
    <dbReference type="STRING" id="74873.A0A084W9E7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014844-RA">
        <property type="protein sequence ID" value="ASIC014844-PA"/>
        <property type="gene ID" value="ASIC014844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014844"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013590"/>
    <dbReference type="OMA" id="RWLFKEP"/>
    <dbReference type="OrthoDB" id="10060229at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="170"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="369" mass="42645" checksum="A6DC0BFB2DD770FF" modified="2014-10-29" version="1">MTKATTPDRHRQQHAAAATTTRSLPLVPALVAVALVLCILPAGCIGQRESQLRLGKAVNVFLRYGYLSISMKVISYNDSERWLFKEPTNNIFKGLDLLKTEEYEVKPGIFNGDFHMEFCDNRRQLFQAYFRDFQIERLDSPWRAYTEGWHPEVAAKKLGIQSKYLERDDYCYVLVRVSRFRDSARFAKPIPPNQTLEPDVGRKVQSVVIGDTTSAVQFMNRYGTHYINAYVTGNSLYQVFVFNKRNYAHVKEKLKTRGVLALSKVDLYEHFAPWYVEHMGKIRCASGNATVEAWAARKLRLSYYVFTYSSLLKLHGDGALLRILSELLQNEAILQLDLRSLSVIFKDPAKRAWYEEILDNYLKLWEVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9U7</accession>
    <name>A0A084W9U7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015001</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525325">
        <property type="protein sequence ID" value="KFB46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9U7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015001-RA">
        <property type="protein sequence ID" value="ASIC015001-PA"/>
        <property type="gene ID" value="ASIC015001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015001"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015001-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6642" checksum="00868374655A740C" modified="2014-10-29" version="1">MSRIENVTGVAANGRYTHDDGFQSGVTFKEPQHNFSTVATGSVRIELSRGRSDTVRVNSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9V4</accession>
    <name>A0A084W9V4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015038</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9V4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015038-RA">
        <property type="protein sequence ID" value="ASIC015038-PA"/>
        <property type="gene ID" value="ASIC015038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015038"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015038-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7529" checksum="885D6D166D2A5B0D" modified="2014-10-29" version="1">MDIAGPHADADSSSTFKAPRVPSPFQTPSPHSSQTLQVSGNIAGKRKTDDQTLTDSDASCNSKSGEEPVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAQ2</accession>
    <name>A0A084WAQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000374-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00015326</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WAQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015326-RA">
        <property type="protein sequence ID" value="ASIC015326-PA"/>
        <property type="gene ID" value="ASIC015326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015326"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011415"/>
    <dbReference type="OMA" id="CFYVAEQ"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="7">
        <location>
            <begin position="707"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1671"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2048" mass="229828" checksum="34A02511F3C08AC3" modified="2014-10-29" version="1">MITASEPLEYIPRGRHPMSYHPGPLKKEKPPQSLPEEMLLLQRMQNVTLSPGREDPSEFYSLREVAITEVTDCHALMPYVCTEEELYVQGHTAVWSHSLGSSPTSQPFTAFSIERPIKYAFFCPRRFLEPDTMAPGQRLDRDGICVVDDEVLQVYCSNGDTYGAKLECPISAIWPTPYGLLLEKDPARSLVLDTPMPRVFTLPYPTDEMKPVLLVSTDMFVSCDYLTRSDHRVVFACEQINLVVLYDQHERRHFLCWLRQATDEEKDQVQQTFDACEDGDNDGVDEDEQYNMMFGEDRVMNDYPSYFKRQSNVGPSTSGFPHVPPSRTSPLPPFDRFPPEFISEADGTGSNAHTSKPTATEEFHKGIGPAENWESLFGSEPFETCNIRQMGFAEPWMPIVPEYSLECIWKEPSNVGAHARRTSDAAWSGTSKGEMASVGFLHTDLVGSHYICFLQPDITRLLLVEFKKETKPETGECFALAACAAVSLERLNLFVLLDPTGKLMLYSGPLLVGKVHVSGLLQTSFLSSTGSSMSGTSSLRGASSTWKRSSLLPNVTPYDSKFEEELHLLSPVRGVPGGVEGKVRSDVALFDGTGTRFTIAFGGGITDAGGNGRSFRVILPPLADSQLVRRCLVALQHALPRKTAHQFFIRWYSTRNVPGTHAGFSIRQEWTMLQSLLLSAMGRPTTGDIGCTNPERPSCPSSEPSPSFVCSLKKRRKRENTVGTDADWEYLLESLAQGERIAAAPKDSTVNSSYKDPNVAHSLYNYIPQVLEVLHLLYEDFKLDTGLSQELRLLGEFLYIVAKDAHASNYEQHYFLDFPELCDQYRTNAYQLKDATLVNAIKENSTRLPHIFRYLKAIVQARPELSGMQRRQDGTAFAPYPHIAGINDRSRDVTVLVALMFRERRLTPWVQRQLDTLLTAERFEARLVKPLLMASKASEPGRCDVFGNTVLHFLIEQGYTRQVLSDLPLAVHFLLQQMLEPLRQSTVHGHDAAVYSLLLRPELHEHAVSAGVAACGSLVSQSERRVVDRERNGERRDQWFTDMAEFDALTGVVSTKEDPQKLEREDGMDNLDVELLRLRFPYDQRISDVRSFLTSSARVLIDIPQGPNVSDHDFIEEQERRLYSLCLRTMALPIGRGMFTFSTCYQGETELAQIPRLCLTGREPLRGATIEVVQLEVPAHMNLWPTFHNGVAAGLRICPDTPHLSSSWIKNNKHASKRTPPAGNNCPFFPGSEAMVEHGGFLLALGLTGHLRKLSMYNVFDYLVRSNELMRIGTFTLQVAALFGIGLVFQGTAKRHIAQVLLQEIGRPPGPEMENAVDRESYALAAGLALGMVTLGRGEQLAGLRDLAIPGELYHYMNGGTRRMTLGAQREKYKLPSFQICEGDEVNLDVTAPGATLALGLMFFDTSDPTISGWLQPPDTKYLFGFVRPDLLLLRVIARHLICWREVQPTQAWVTDQVPQILVDAVAYVEGGEEERPPQFEVTQKPNIPRVERELYCQAHSAIVCGSVVGIGLRFAGTADPVAATTLYHYLRYFIDLRHPKPRDANTPAGIRSRNLAKFIGGQVLENCMLMTLLALSLVLAGTGDVRVLRAVRMLRSRVGIPGVTYGSHMAVHMALGFAYLGGGRYTLSRSPPAIAAIVCSIFPKFPVYSNDNRYHLQALRHLYVLAVEPRLFVPRRIDTGNLTQCQIRFATRPTPLAPQTIETHLSPCMLPELHTLEWVEVCDENFYPIRFNAQNWNMLETIMAKRGYIDVVQHVGCLSYLEDPTRTVTMHLQNLPGRENSTWAVMAELLLELPSQPMIVRLAQTLLLPPKRYLLRAAIEPKRNLPEANRALEYFQAVVAHCVTRDRFHAIPILFDLTYLLLDPHNYKAQLPTDTWSLELFKAILGRTIPMVTEEGEVLPGKLLRSLVLAAHGKWTGDLLHYRTVLLNLCGIFSARNTPLFDRMSTLSLDTDDKEETDDVIGGNWPKVNRRTSILTNVARMAVQYELPLDVIDRELLRSLWPQNEPSRSEFVIAMAIRHPELAARTTMCLADLLNLRQSAKPKEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAQ9</accession>
    <name>A0A084WAQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015334</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015334-RA">
        <property type="protein sequence ID" value="ASIC015334-PA"/>
        <property type="gene ID" value="ASIC015334"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015334"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015334-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="19244" checksum="D9FC3050A363E32C" modified="2014-10-29" version="1">MKFLLTHDRRPSPTDTAILRRTAIRDEMMAILDVSIERESAFRKKPRAVLQERERPARDALRVSSAAVAVYAARETGQLPRCAMLRSIGAYIALYNSRSNSTKCPPGGVFWCLPACNTRRGQKNPRMNRRMNAPIQHEQKCTCIATCNYCYEMQRICRDARRHLTEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAV0</accession>
    <name>A0A084WAV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015493</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015493-RA">
        <property type="protein sequence ID" value="ASIC015493-PA"/>
        <property type="gene ID" value="ASIC015493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015493"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10128" checksum="5C65D5ED42F45278" modified="2014-10-29" version="1">MVVENSTVHSRQAQHLTPMFVCLPEILAGGPGGGWSVNKIPSILITAAASGKHDGKGWKVSYRNAEVHNLLNQLDSLVEVECRFSGVDSDDGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEB5</accession>
    <name>A0A084WEB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016871</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016871-RA">
        <property type="protein sequence ID" value="ASIC016871-PA"/>
        <property type="gene ID" value="ASIC016871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016871"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7759" checksum="F9F96B3FC1D15A47" modified="2014-10-29" version="1">MRKNKQWNGSQQKRQSSKQKKQKPKQTTKPNLKPPAIQNKNVKTKNKGHLFWRRARNRYGNISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEP6</accession>
    <name>A0A084WEP6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006147-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016690-RA">
        <property type="protein sequence ID" value="ASIC016690-PA"/>
        <property type="gene ID" value="ASIC016690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000773"/>
    <dbReference type="OMA" id="WISGRQP"/>
    <dbReference type="OrthoDB" id="7742929at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784765" evidence="2">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="391" mass="42208" checksum="1AF02DC9CB28FEC7" modified="2014-10-29" version="1">MPSVAKVLVLLTVVVCGIWGQNTPQEVSTVAPEDIFSLSEEDFQLWISGRQPKAWGGSSAGSDSNTVGTTTTPRTTSASVFRTTSTTPSPFSTRTTPTTQATTPNPLEFFTVRPPPESDGKSWFEDEDDGTLRPDVLGDQFRPAGEDFAQWLDRQMNKVQEVTFTPQTTLTGDQFPGLVTRLTTVRNRIPAPTTFAPSAADAVTVPPTPLPPSPASTSFPALPQLEPISPIVPSTAFAGQPTIGGGQQPVDLQKWLRDQLQLSQSLTDRLLAQWSPNGAFIRTDGHRYTPTAVSYQTSALIHGLQGVSHTGQIRNDPPLPFPGTSHSTDSYLSHQKPTVQPAPTPVAPVVPIRRVQPTVAPVFFPAGSYYYSAPSVPFVGHYRAPVVINYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFC0</accession>
    <name>A0A084WFC0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00016908</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01023328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFC0"/>
    <dbReference type="STRING" id="74873.A0A084WFC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016908-RA">
        <property type="protein sequence ID" value="ASIC016908-PA"/>
        <property type="gene ID" value="ASIC016908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016908"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016908-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="242" mass="27597" checksum="CD22034AD35743E1" modified="2014-10-29" version="1">MTRLVHVLHAGRLDFRRALQLQRAVASLVHRTNNPPDDAHHQQQWGSCRNVLITTEHDPVYTIGIRTHGYDSAEESRLRALGADFVRTNRGGLITFHGTGQLVAYPILNLKLFQPSVRWYVCHLERSIIELCRRFGLRAQTTPDTGIWIEDRKICAIGIHASRYVTTHGLALNCNTDLEWFRHIVPCGLVGKSVTSLEAELHRPDLTIDAVMPEFLSSFRDTLECDLVPMDDELRLQLLREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFC6</accession>
    <name>A0A084WFC6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000844-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016915</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFC6"/>
    <dbReference type="STRING" id="74873.A0A084WFC6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016915-RA">
        <property type="protein sequence ID" value="ASIC016915-PA"/>
        <property type="gene ID" value="ASIC016915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016915"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012779"/>
    <dbReference type="OMA" id="IPWMEVD"/>
    <dbReference type="OrthoDB" id="535992at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF138">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016915-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="27827" checksum="F867D789DA97B445" modified="2014-10-29" version="1">MAPDTVASPPAAPDSSQSSACSQPTDSSQPTLVKQVQRMLTPPADLLEWKDMPQHLQFNPYVLTGYRPLQGVKGCLSSLFYVHNETINILTHVPAMMPWEKDYRFLSWCHLVGSVAPWCGSFVYHLFMNLENGEGIYYRLLQLDMLGIWISQSFGALPMVTATVYCLSSPLKWLLIISYSLLCIWGLYKAMTASSPWQRRLCFLLPFSMRIILTLLRISKLGGGNPSSLTHVFLQLRCRFERGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFI2</accession>
    <name>A0A084WFI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016980</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016980-RA">
        <property type="protein sequence ID" value="ASIC016980-PA"/>
        <property type="gene ID" value="ASIC016980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016980"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022292"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8970" checksum="50F3F1806FB8029A" modified="2014-10-29" version="1">MSGQCLCGCGSAVMWECKLRMMLSSPDDQTEYGMYTQRMLRFWYSLPSQQPGPSNVAQNQAVPKKYVLKVSFSLHEANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGE7</accession>
    <name>A0A084WGE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006490-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017405</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGE7"/>
    <dbReference type="STRING" id="74873.A0A084WGE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017405-RA">
        <property type="protein sequence ID" value="ASIC017405-PA"/>
        <property type="gene ID" value="ASIC017405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017405"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021616"/>
    <dbReference type="OMA" id="SRETDVW"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000689">
        <property type="entry name" value="Tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000577">
        <property type="entry name" value="Tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF481">
        <property type="entry name" value="TIE-LIKE RECEPTOR TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="822"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131135" checksum="8D8021381F7F5C73" modified="2014-10-29" version="1">MTKRRMTNRDNKLMSVLQARRTALSRDRWRKEYHTPASALTKASLQRQHAASVAGNLVEDSSTPESNLIVPVQGMMAGSGRQVSGGVADEFLDTDESIHGMYVVNPRTGKIAIQQTGSSIKLAKETNNFIGAGPPSGNKSLEITKLSSAKATVATSPVPHQTRGHYAETRGKRLRERKTFVPLSTERSVEESDLIPYQFFGQKLLPAHHKGLDARNQVINSRRTHLNKLKEDPSLLEMGELPVAKPSTEKSKFWSNRYPSRNGVALNNYLRRGSGSTTSTSTTTTTTTSTYSPPGAGMVHSDTLTNSMIALSNLSDGDGEDEKQVFSRSANYTSSRKTEEDGAPTTISTTDVKEPSSIFEQAASSTASSELPSNHKPEIEQEYSSPPGLYNSGIAKLIINYPDVATPEEFYHPLHTFETHAQIVNLQEATEEPLPTTVAPPQAIEQEEEEEDYETPRNLVSLPDINQIFRNLSTPTTTEMTTTTTKATTTRRALTSTMAPAPARSRLNTRVYVPVSRSTTTRSTTTPRTTTTTTTTTTTTERPSFQDEEIDTPTTVLILTSNPTTTESTSTTTTTIPVRTTTDTPASSVVPSATPSSVPARTTTIRNFQRPSALPTMASPPKSTPSSRPVTTTTTTTTTTSTVAPPERGTVSVFTGLRPSPPELTQVNSTGVEAGFNPILSHIFPKLTGPGLPTRAPSSVDLSLAFTSPPPADHSSGTKKPAVSFDGVLLHHNSDVVIEMRKMNTATFVLAGLGMLPIVIIVLYVIKATVFNRENKVSHDLERYIPDGQPPISPVVRLEQSDTSSATDESIMTEHDFNRGNLRFKSLLGEGNFGQVWKAEADDLAGHLGTTRIVAVKTERSDNGHGDLKAEAEIMRKLGSHPNVVTLLGACLEQDPQLLIMEYAMRGRLLSLLRAARGAVNGLAPSVHNNRPPIMPLSPRRLAGFAHDIARGMEYISEKKIVHRDLAARNVLLDHNGICKICDFGMSIDLEKVKSTHAQIRLPRAPHAHSESRFKFDLSARSFGIGRHHGHDASGRHGGGDGGGHSSHGHDTKSRPALPIRWMAPEALSYHIFSRETDVWAFGIVLWEIATLGCTPYPNLSGREVVRSVPNGARPEVPADCRPELYELMQRTWRKDPRQRPTFSEARTCLARTLCQWQLEDNDTSNTSEYLDVSGFSEDLEQGMVYFNRRISEFECEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGV7</accession>
    <name>A0A084WGV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017456</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023739">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="19"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB49451.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9685" checksum="64DB40976A1D84EF" modified="2014-10-29" version="1">MHLQIDVQCQTRMDSFRVAISSEESTRTPPPSSRTDVHKQNNIQPSNYSAAAGLVTQHNGSTRYICMAVVVGKHRHQLTSFCSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHA1</accession>
    <name>A0A084WHA1_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Protein FRG1-like isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017608</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHA1"/>
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        <property type="protein sequence ID" value="ASIC017608-PA"/>
        <property type="gene ID" value="ASIC017608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017608"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10730" checksum="C07BB2A4610D1E5D" modified="2014-10-29" version="1">MAWQDHPVPTQNQVTSFGRSSPKRWQVPETKSTVRDDRVMNGHSDRIGKDRWEADLRGGRWQVWPQKSRPTQRSDRHTTSGPQEMFAVRGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHA8</accession>
    <name>A0A084WHA8_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP007969-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ZHAS_00017616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB49602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHA8"/>
    <dbReference type="STRING" id="74873.A0A084WHA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017616-RA">
        <property type="protein sequence ID" value="ASIC017616-PA"/>
        <property type="gene ID" value="ASIC017616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017616"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000461"/>
    <dbReference type="OMA" id="VPLQTMY"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="271"/>
        </location>
    </feature>
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            <begin position="309"/>
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        </location>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="346" mass="38852" checksum="48890F7EFC77DF45" modified="2014-10-29" version="1">MSRLLKLAQKFNCFYLNGLLKGDCRPFVVDGHQVGLVSQNVIEQLLKYPEVFHIRAPEHGKQNIVELNPAFRDYNTRSQQVDRILREFREQGMFVALKGWRDECYDVKSSVSGSLLKMDRSATCLFGVRNYGVEINGYVRHPTKGLCIWLQQRSDTKQTWPGKWDNMVSGGLAVGYGVHETAVKEAAEEASIPGHLIKNLVSAGCVSFFFESERGLFPNTEFVYDLELPEDFVPDNSDGEVQNFQLLPAHECLERVFEPDFKTTSCPVVIDFLIRHGIITPENEINFTQVIELLHVPLQSLYTYRTPTTPSAAATNGGNGSATTPNERQDLSGTISTNKSIENGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJW8</accession>
    <name>A0A084WJW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018552</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018552-RA">
        <property type="protein sequence ID" value="ASIC018552-PA"/>
        <property type="gene ID" value="ASIC018552"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018552"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018552-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6414" checksum="43ED5C4EDF5BA43A" modified="2014-10-29" version="1">MENFFLSFDGPKARCAPESFHDGSERWPTFSRRRRKRTNHSDPGPTARIGHRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK25</accession>
    <name>A0A084WK25_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Xylulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018884</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018884-RA">
        <property type="protein sequence ID" value="ASIC018884-PA"/>
        <property type="gene ID" value="ASIC018884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018884"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8676" checksum="E9F415D23225A07C" modified="2014-10-29" version="1">MLRMGGPRLGRNPNSSGGRQQQQPGTGFGGTFRNKNKTRQQASLRPLMAAVPEGFCFCFPDRLRTVWMAFARCTQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKC1</accession>
    <name>A0A084WKC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">L-aspartate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018700-RA">
        <property type="protein sequence ID" value="ASIC018700-PA"/>
        <property type="gene ID" value="ASIC018700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018700"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20363" checksum="CC5862DF9D4FDE63" modified="2014-10-29" version="1">MWHAHAGALVEEVEFIEFAPPHFANPGTERCKDTRGVAGKCAHGWGGWEIKTPLPPENYPPRVTVFYGRRRKNLADLPRRYKLRSYVDPFDVERLSLGRTPPPDPLEKSERVQQTPLANDNPWGKTNKPTINIALPHLLSSLHLASRWVSENHFKNHTVSGFFGMNMQRNQKRLRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL22</accession>
    <name>A0A084WL22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019265</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019265-RA">
        <property type="protein sequence ID" value="ASIC019265-PA"/>
        <property type="gene ID" value="ASIC019265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019265"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12104" checksum="AC281CE5656BF52A" modified="2014-10-29" version="1">MQSGGSAEGAQQTSHHYSDQNASVTKAQGSVEFPRARSALVQRHKAKVLTEPFPPNGSNKEHSQQLGQGSRGMNGGLFGTYRRVSCMTFGIVTVNLRAPERQGRTTSSSRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL55</accession>
    <name>A0A084WL55_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018990</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018990-RA">
        <property type="protein sequence ID" value="ASIC018990-PA"/>
        <property type="gene ID" value="ASIC018990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018990"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018990-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5519" checksum="377DEAF2C9C2537F" modified="2014-10-29" version="1">MACREQTFAVIQCRTWMMMATMVGDDGMVANDAVALACMTVASTSCNPPCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL60</accession>
    <name>A0A084WL60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018995</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024187">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018995-RA">
        <property type="protein sequence ID" value="ASIC018995-PA"/>
        <property type="gene ID" value="ASIC018995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018995"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="205" mass="22330" checksum="8E6ABEB901AD6995" modified="2014-10-29" version="1">MTATVLILAEAALDYCAILWKPWPFCSCSSSYNDGNNNSVNCSTLNSRLRLATSCEPFRGWRWGGGTLWRGVVPSPFASSTGDPQQLPFDFENKILLPFFPISSSLRTLSTGSSLPAPYEALNSFSTFHPPVVRLRPMSVRIKMKCVRGALALPSDMPTGVLLPSLHDAFHPNPHSAGPTHTRTPNHHHGIDATVIARPCVSCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM09</accession>
    <name>A0A084WM09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">E3 ubiquitin-protein ligase Mdm2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019298</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019298-RA">
        <property type="protein sequence ID" value="ASIC019298-PA"/>
        <property type="gene ID" value="ASIC019298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019298"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019298-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12243" checksum="D6D49F65174C823C" modified="2014-10-29" version="1">MKTQRDVQRGAGKGIKLFECIENAASNQKHIHHTVPWARRGGKAAHRDDCNPITQLADFQIASIAKGNPGGTGKSNPIFPIPKRSALQVFASSSVLSFPFPLAAFPPDKLLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMM8</accession>
    <name>A0A084WMM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019527</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019527-RA">
        <property type="protein sequence ID" value="ASIC019527-PA"/>
        <property type="gene ID" value="ASIC019527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019527"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785154" evidence="2">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="19553" checksum="FFE09676C646A1E9" modified="2014-10-29" version="1">MASSIQQLIVVVAALIFVCAANGLESYFETENSDSQECSLGEDNRLPYPYAMHGKPPQLGECADCGFVIVEKRHHYCIPGKSVIKVLRRKPTCNCKHPLGRRDGSLYGTESKVVPNYVMASGASQGPSPVAESMVPSDQVSRMLRTLISDRGNYGAESDKTATPQYRTLDSNSATRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMN6</accession>
    <name>A0A084WMN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006541-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMN6"/>
    <dbReference type="STRING" id="74873.A0A084WMN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019536-RA">
        <property type="protein sequence ID" value="ASIC019536-PA"/>
        <property type="gene ID" value="ASIC019536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019536"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005640"/>
    <dbReference type="OMA" id="MIALDSM"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="370" mass="41285" checksum="E45FCE710BDDBFBD" modified="2014-10-29" version="1">MQMALTVLFETTKYEVENKSFLFQYGPTIGTTEFRETLASFLTEGYCSEVNKSDLVQTSGATSGLHLILSTLVDLAGVIFVDEYTYMIALETISQFNTMKIVPVPLEEDGPNVGTLKGLFEQHRFEAKGKLFWGVYYTMPTFHNPTGIVFSEEKCHQLIKLARESDILIACDDVYNLLHYGDPDGAPPKRLFAYDIADLGVVEGWRGNVISNGSFSKILSPGIRLGWMDGVLKSGGAANNYTGGIVSTLIQMGLARRQVQLYSSNYSARLQAMLETLEIHLPKECSFSRPQGGYFVWIRFPEHIDCVALNQYSMEKHRVAGVPGPRFSFSGEARNFIRFTFAFHAPDYLRRSVASFCAAARDFMAKTGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMQ6</accession>
    <name>A0A084WMQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006574-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMQ6"/>
    <dbReference type="STRING" id="74873.A0A084WMQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019558-RA">
        <property type="protein sequence ID" value="ASIC019558-PA"/>
        <property type="gene ID" value="ASIC019558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019558"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016788"/>
    <dbReference type="OMA" id="NAMFPTV"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF23">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="5">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="5">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="669" mass="72167" checksum="285B9BD15FC245F5" modified="2014-10-29" version="1">MSEQVELAGLPPGWDCKYDSRTGRYFYVNLFTKTTQWEDPRARIRQLQTGAPTHLSNDSIAMQPVHGSPYHVYPTSNSFYPAQAAFQNPPSGVPSLNASPNLAQRLQQQHQQQQQQIEMAPIARSSPRMGLGRQGMVETTFSTNVPAAETDLTVAKINSMFPTVPETHIRMLLKKYYNREAVVISALQVEKHPLTTPGPYSTPPLGHRPFHNTAMGVVSAFQMTPVLSGRSEMSSSRTGSPVPRPASGASGSYYGGYGSPRNGPMDGTGYRSSPKPHSSPKMKLRYMKSIFPKAEETLILDVLANADNNVQSASQALLKMGYDKREQPVPQRNASRKGTGGSQGADDGIPEEPKTPTPKLKSPEEKKKIKTRLQGKYKDTPEKVIMMALESVDYSEERAKKILNIVIQEDRDKKKSVKIEAPHKSDEDKENARTGSAGPSRSNSTTSSQPRTPLVKRAPGGALAEDGITSPPATTSEGVQSPSGAASTVVDGKTTEPEFSSSSGNESSLAVGDSSPESPPERHHHDAAFRAGGRAANVTGAKQSFRPKAKTDHAKSSSSEDESCEQAAAAKMDGKSPQLATRIPTKGPNVKLFKGPNDDLLLADYVTWNGANPDLAKGSQKLSGGPDRSIRIERTYQAHGPNGDLCKGPVGSLAKGSMYGQMMKDVKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNM6</accession>
    <name>A0A084WNM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003855-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019975</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019975-RA">
        <property type="protein sequence ID" value="ASIC019975-PA"/>
        <property type="gene ID" value="ASIC019975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019975"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005860"/>
    <dbReference type="OMA" id="PYARSSM"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="134"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019975-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="363" mass="41071" checksum="5C35FC89377F6073" modified="2014-10-29" version="1">MPKTAETKFVNSLFLTNLIQSQYGESEVKIKAYEIEPASADINDPYARSSMNRILIKYTSKENPKDAVITFVAKIKPTEGLLVEQFKKADVFEKEIVLYKSVLPSMVSMISKLGSVIELAPQLIYSSETPSDLVVLEDLTVRGYSVENQALGLSFEQSKMAVEKLAFFHAASAMMLEENVLVFARFSKGTFHNEYKDRLNYFPDTIGLVAEMAADLGLSSTVAEKLKKLPAKTLPKAIAAFESDIKGFKVLNHGDFWTNNIMFKYQGNELVDAIFVDFQNCVVGSPIIDLVYFLSSSPAYDVLQKHKDELVFTYHETLVLLLQKMGYLKLFTPSRYHRSYARRMPRTRHPCSQPCTVQTNRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNN3</accession>
    <name>A0A084WNN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024643">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019983-RA">
        <property type="protein sequence ID" value="ASIC019983-PA"/>
        <property type="gene ID" value="ASIC019983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019983"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6493" checksum="7057E280811758CD" modified="2014-10-29" version="1">MGAGSEDQIGVSNCNGPKELAGQKTDQQRFITTRLGQPFEGRSSRTSRALTKGAGRVPVGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNW8</accession>
    <name>A0A084WNW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Chaperone/peptidyl-prolyl cis-trans isomerase SurA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020092</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020092-RA">
        <property type="protein sequence ID" value="ASIC020092-PA"/>
        <property type="gene ID" value="ASIC020092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020092"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13203" checksum="0CC2B103DB928748" modified="2014-10-29" version="1">MAWFFLIRHSECGTDWEFAASMGLIIFGCKLNYAIVRQVRAGIVSNGFFVRQYETGSLTTNCEFPGWWTIGDRYPSREAGGDRIGTGCINEPTEQRFRAHRCKCYSLPGSSETDMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP78</accession>
    <name>A0A084WP78_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012960-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020223</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525366">
        <property type="protein sequence ID" value="KFB52022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP78"/>
    <dbReference type="STRING" id="74873.A0A084WP78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020223-RA">
        <property type="protein sequence ID" value="ASIC020223-PA"/>
        <property type="gene ID" value="ASIC020223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013264"/>
    <dbReference type="OMA" id="CEYQCGL"/>
    <dbReference type="OrthoDB" id="8036166at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="682" mass="72492" checksum="CFDC45C378112F5C" modified="2014-10-29" version="1">MANRCPRSTLWPPNSTSSAIAPPTAAASATSGETPSRPPQAAVGSTRTGGTVVCGLIGKFECTSTDGTADVKVTANSCRDSDSALISGCRIARGAAHGGGALVDGFRQGPSGNRNECSDKTHPNGIGGGGTGGRALDERSGEMPEMDASVHRARRRQRKTVVYSRLCLGDALMFDDASALLRPDLRKANRVGECPEENSTRSTVGTLGGPAEVIRFPCVERLIELYANIIRQKEAEVQRFMSSIVRDGDKSRLDKGGSRVDGLAELQQGDIREERALPASVSLESLPSTTTTTTTTTTTTKTKTVPLGTELESDTKHASPVLPIDEVERTENPSPDAQSDEGWRSSTQLSPYGSSDEEDRLQALVHQDRSNEQIAVSGDQDFTETMKNRDKVTRSASSDSALGLDDDLSQQEQQQMIASVGKVRRLTLGVSDIPLRSALLPVPEPTTLPSLTTPSGGSEHCPTVVRSKMILEAQVIELPLAGDGSSEQHQQLGCPSSTSVSRRESAQSYISETGDGVRYVRTPSVVVSDYSDDTMCGITLEEIEYFRRHRLRRGSADCESDISAASSCSNLNYCGSSISALEGCEYQCGLRTPERKVSDCSTCSTVSCDEDEGYSVVRAKLANLALPAAGAVAGTPSSVPPNVGDSNVPEQKAPAPEDADVRICSKKKVSHTKTNACQDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPI9</accession>
    <name>A0A084WPI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020456</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025080">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020456-RA">
        <property type="protein sequence ID" value="ASIC020456-PA"/>
        <property type="gene ID" value="ASIC020456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020456"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7723" checksum="B2587AAABD1B4E24" modified="2014-10-29" version="1">MDGDSPYTFGAQVGGFTQGAEFAQLDRARERTTTPGSTPSPGGVFFFPVRGWNVAQRTFSGSFRNAEPPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQA2</accession>
    <name>A0A084WQA2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">2-hydroxyglutaryl-CoA dehydratase D-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020616</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525385">
        <property type="protein sequence ID" value="KFB52396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQA2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020616-RA">
        <property type="protein sequence ID" value="ASIC020616-PA"/>
        <property type="gene ID" value="ASIC020616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020616"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020616-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="29496" checksum="DB30A178453BD09A" modified="2014-10-29" version="1">MCICTADRAFQRNGTCLHNHTKRPIRCQVHQTFDKTVSPRSRLPDSMYRIHLGHRASSRAHFHSHGNGRKFFRTTTASTASRRRENSSDIRVTSKCGGGEEEDARPYLMECINKQHPKQRPEHDPETWRDGKKGKTKHYRQHVQVHFHSFRPPGVVFSSSRDADGFVSRSRNGSQHSGVTFAYCHPLGHLVFGAISMQLTLARLALLAQCQRGENENLNTFHGTASVENRPIQRKRSKGRFYFFVFERRNRKILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQH0</accession>
    <name>A0A084WQH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008958-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020705</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQH0"/>
    <dbReference type="STRING" id="74873.A0A084WQH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020705-RA">
        <property type="protein sequence ID" value="ASIC020705-PA"/>
        <property type="gene ID" value="ASIC020705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020705"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020646"/>
    <dbReference type="OMA" id="RIELIMK"/>
    <dbReference type="OrthoDB" id="7755558at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785040" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="20610" checksum="8931E25D6F8C2DDB" modified="2014-10-29" version="1">MTFKLGSVVLFILVTSQALEVAYEKMEQISGFDVLESTLRVRKYNRTTMVLNGTLIIKKEMNNTFVIHSNFYHSPLGNQQWNHYPMKLPARGICEFLYSIYDEYYKYIEDIVNLPKKGECPIMPREAHVYDKVFPSEVIPPVIPKGLWKAILTAKVEDVERTRIELIMKVYSDKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQY2</accession>
    <name>A0A084WQY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Sorting nexin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020895</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="60"/>
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    </feature>
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        <location>
            <begin position="91"/>
            <end position="123"/>
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    </feature>
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            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
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            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13880" checksum="9FA8493ECBDB593F" modified="2014-10-29" version="1">MHKIVPFRLTHILPPHINPAARRKPCHEASKHNASDLSGRSRVKIQQPTTDSRQTTTPRKATITHLMYECAVLRHGRNQFHLQIEPARAGSALSSYTAASNMSYRDVPDTSETGRRRTTTWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR67</accession>
    <name>A0A084WR67_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00020987</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB52711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC020987-RA">
        <property type="protein sequence ID" value="ASIC020987-PA"/>
        <property type="gene ID" value="ASIC020987"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020987"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020987-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15344" checksum="EB23CDDD44C31CD6" modified="2014-10-29" version="1">MDDCEAADRIIQLNVLLALALATIQYPSPGLPAGQKGLGGIGTGNGTVTDTARTQAPHNTRRTVKRWTTPRARPYRTSCSQELKLECCHADPATALQQPPCRAERIMIRRGVHRGLQLVRSLVAIPEGCRTPHALASLISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRS4</accession>
    <name>A0A084WRS4_ANOSI</name>
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        <submittedName>
            <fullName evidence="5">AGAP007007-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00021201</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB52918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WRS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021201-RA">
        <property type="protein sequence ID" value="ASIC021201-PA"/>
        <property type="gene ID" value="ASIC021201"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021201"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003858"/>
    <dbReference type="OMA" id="MAMRITL"/>
    <dbReference type="OrthoDB" id="7765419at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785105" evidence="4">
        <location>
            <begin position="22"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB52918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021201-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="745" mass="79151" checksum="EDD09666B68FBD4F" modified="2014-10-29" version="1">MAMRITLLAACCLLATVTVLGSPVDDSVRAALFRRMRLGGPKGQLTVASGSGLLLASTAGETFHNPHERHARDEPVAQLHHHHHHHHHLHRLHSFTAPISHTILPSEGTLSSPHATNPSQASRARPRRHFDANHISSHLANDNSIIVRSNIPHRSPPSSHHHHHDHHPHAHNHHTLRSHGTHRARNHDGVGVGGSRLNNSTDGQRQAVGRNNSLRRSAPGSSSTTAPGVDGGDDRRRLLLEAEISRLTVAQDGQLREHAQRNSFASFSDYFLAQLHKQNVAVAFAFDGGQLQEQQLDALAVSASEIPFYDDVDGIGDRRVIGSNPEGHTLTPVLNTTTTTTNITAHTTNTTTSTTTSLPAKVWGEGTESRFGPVLEFVLERIQSIFSVYKHEDQSRPGVPVADTLDSQSQERKASSVAAAPAPKESKELPEDGESASTAAPSPIKGGLNRLFARKKYSPLLRDSSKVATTEGSPAASSTVAQESSPSADSTTPSTSAGPSGSTRRTRPTRPGKLPRSTSPKPTVSVKPTKISSRFSKPTTEASESTVASVTQRTTRGRRTRPSKPSKTGTTTTTTTTEEPTTTTTTTTTTTSTTTTTTTTTTPPPPTTSTTTTTTTASSPAAVDGSSVASSAPVADPSPALPNVDVTPAKAASESLTSGSTTTTTSTAAPKQLTTATTTEEDDSEVPPRIVSNGQQPPQRDEPEPVVKASPVKPERVIPVVEKQDELNENESLLQSASYDTSSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSZ9</accession>
    <name>A0A084WSZ9_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP003388-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021651</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSZ9"/>
    <dbReference type="STRING" id="74873.A0A084WSZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021651-RA">
        <property type="protein sequence ID" value="ASIC021651-PA"/>
        <property type="gene ID" value="ASIC021651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021651"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018012"/>
    <dbReference type="OMA" id="GNYGETR"/>
    <dbReference type="OrthoDB" id="8062388at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021651-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="560" mass="53652" checksum="A3B5BBFBAFAA87F9" modified="2014-10-29" version="1">MMDMSGPPRGGYRGRGGPPRGGYSDRGSSPFPFRGRGRGGGPPMGGPRMGMGGGGPPGMMRGRGGMMRGGGGPPRGMGGPPRGGGGPPMSRGGPYGGGGGGGGGGGRPMGGGGRSSYGGPPSSVTNGSGPPAVMPAVENGDGGGGKPVEANGTTKAVATTTGGGAGAAQGGGAGGSGGAGVGSGASQSSAPGGGGGSEAEHMSPKQSIKTADSSSLAVASQESSIQSTHSSGGPYHSSSRGMSRGRGGFMSRGMGRGRGGGGGGYGGGGDYGGPRPFRGGMGGGRGRGGGGGGYGGGGGGGGYGGGGGPSGGYGGGGGGGMGGGGGGGGYGNAPPSSYNPMGGYGQNNGGPGGGGGGYNVQCPPPPRQFDSRQPSNQSAVPPIKRGGMPGQVVPCPPKAMPPHHGSAAPVPSYSAPPQPMANHGGYNDPNAHAPQMEHQYTHSATANTAGYGNTAAPQTGYASNGYSQGSYGTTTMASTGYPSTGTEYDTTHYDYSNSGTYDTRYQSGYTQDYSQTYGTTTDYSGAVSTDTYASQPYDDRSTAYSGYVSRVSSLFPLQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT74</accession>
    <name>A0A084WT74_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">F-box only protein 15 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021850</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT74"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021850-RA">
        <property type="protein sequence ID" value="ASIC021850-PA"/>
        <property type="gene ID" value="ASIC021850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021850"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021850-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13412" checksum="DC81BCE451ECE695" modified="2014-10-29" version="1">MSDEPPHQHNGRENHKRSIKLREEMKYDPRAIALFHFGHDRGSPFARSRTIGCVLGVENESGHFRAAHIFRQCSARSHIVKAIRAGVWTGLPEDTYSLLGVCWPIVSDLTIVLENAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT95</accession>
    <name>A0A084WT95_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021942</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021942-RA">
        <property type="protein sequence ID" value="ASIC021942-PA"/>
        <property type="gene ID" value="ASIC021942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021942"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8606" checksum="B90E679DBB06F2F5" modified="2014-10-29" version="1">MYTVLKISQLVYYSSASALGRIAQRFDGRTGPSNMKIGICTVRPIHLDSAEYFQEEAALPHNQIRLPGERTHSKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU37</accession>
    <name>A0A084WU37_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00022109</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU37"/>
    <dbReference type="STRING" id="74873.A0A084WU37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022109-RA">
        <property type="protein sequence ID" value="ASIC022109-PA"/>
        <property type="gene ID" value="ASIC022109"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022109"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011043"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="47"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="236"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB53731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022109-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="660" mass="76864" checksum="676BC42402C90DA5" modified="2014-10-29" version="1">MAEAALISEQIEDDEVQEILKTGTDLRQYSAQIEKEFKEVENRSIDDYIKESQNIANLHYQIGSTSNILERMESMLMDIQGALNNISTEITSLQKKSVSMSVQLTNRQSIRAQISQFVEDMAVPEEMVATIMDSPVTEKEFMNHLNELNHKLNLMKELNFKESKSSQDVSDVLQKLKVKAMSKLRLYLMEQIYKFRKPMANYQIPQNAMLKYKFFFEFILSNERVVAQEICNEYVDTMGKIYYSYFKSYSTRLAALKFEEAVSKDDLMGLDDSVPKSIFSKASSLKNKSTVFSIGDRGDVLNQQLEAPIIVPHAQQKSRYAYEALFRSEQYALVDNACREYLFVTEFFILRGQQAQELFNQIMGKTTALLIKNLETYVQDCYDTIALFLCIQLCLRYQLMCHKRCVPALDKYWDNLQAVIWPRFEQVFRMNIQSILDCDPTKFPKETGPHYITRRYAEFSAAIVGISENFPNELVSHLLLELQEEVKCFMLRMAAIFTTRKEQLIYLINNYDLVLGVLMERTRDNSKEAEAFRELLSTRSAEYVEEILAPHLGGIIQFVKDCEQMRDKEQTEELKRQERRSLQLVANFSANWKKSLEDLNREVFLSFPSLVTGSQLLQLALAQLVQYYHKFYKLLTPNARAQLVNIHVIMIEIKKYKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBP5</accession>
    <name>A0A084VBP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001970</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524485">
        <property type="protein sequence ID" value="KFB35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001970-RA">
        <property type="protein sequence ID" value="ASIC001970-PA"/>
        <property type="gene ID" value="ASIC001970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001970"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7918" checksum="6F4B427B0DD72DA0" modified="2014-10-29" version="1">MVEKPPGGRSRVHFHLHEAHSNHGTRAYKHKSPLGESPGDQERGWKVAGGRREPDGERLPKRPSNVFEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCF3</accession>
    <name>A0A084VCF3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007549-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00002504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524597">
        <property type="protein sequence ID" value="KFB35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCF3"/>
    <dbReference type="STRING" id="74873.A0A084VCF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002504-RA">
        <property type="protein sequence ID" value="ASIC002504-PA"/>
        <property type="gene ID" value="ASIC002504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002504"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019725"/>
    <dbReference type="OMA" id="MFYTQVH"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF13">
        <property type="entry name" value="DOPAMINECHROME TAUTOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783332" evidence="6">
        <location>
            <begin position="29"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002504-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="498" mass="56371" checksum="F3A61B613B077315" modified="2014-10-29" version="1">MAASRNLWIPVAGLVVVVLATLTGPVGSYSPFKKNNQHGSFTRTGGPNGAVGQREREQERLASPYVAPLAGLEGTGKRMANDFLEDLGKSAFDTVYHWKVIDFMYPSLQLRNNAIRTREFIPENNLPLGVDRFRDRLFVTTPRWNPGVPATLSYLPLPAQDRSHPLMPYPDWSYHTSPRNPDCSKMMSVYRIQVDECDRLWVLDAGVTDTLTNLQQVCPPKIMAFDLQNDELLFTYVLPPEQIKEDSLHTNIVVDVREGQCEDAFAYVADVWRNGITVFDLRKFKSWRTTNHLYNPNPIASDYNYQELNFQWSDGVFGMSLAPVHRSGDRMLLFHPMSSFMEFQVPASILQNETVWEGFGLAAKAFQPVGTRGRLGQSSTSGVAKNNVQFFTLVQQSGVGCWDLNKPYNRNNLGVVEKNPQKLTFPNDLKLDRELQQSVWVMSNKLPVFLYDKLDYTQTNFRVLMADARKAIEGTVCDPRVPPSLAFDAAQLECELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCZ9</accession>
    <name>A0A084VCZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00002782</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011080">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524639">
        <property type="protein sequence ID" value="KFB35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCZ9"/>
    <dbReference type="STRING" id="74873.A0A084VCZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002782-RA">
        <property type="protein sequence ID" value="ASIC002782-PA"/>
        <property type="gene ID" value="ASIC002782"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002782"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000971"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002782-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="316" mass="36380" checksum="FE3A701548E1861E" modified="2014-10-29" version="1">MGQGKRKTSTTQTKIIKIKYNKLNKAKKYETKNNNNNNNNNNFATSYVELRYLKIELPDDDGTLPPVRKIIPETQQQPAKQQTNATKEKPTERIRSCDYARWDQYDPDTELLKMDLDEERHRELVRANNRKNVEPPKIVELPPEMKLSEQEKQVLAEKLRVKGNDFFRAKEFKEAIEEYGSSLELWPTAACFNNRAMAIYCAVLRLEPSNSIALSSMAELSRQLPDLPPPNAFRMTIEEVSNDPVEPTDDEIDFSALVKPKKIIKDRLPTAIKQLKKDTASVIRQGAKEHTARSKQEITLQTDKNVSQRTPLIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD32</accession>
    <name>A0A084VD32_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011281-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002816</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524643">
        <property type="protein sequence ID" value="KFB35876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD32"/>
    <dbReference type="STRING" id="74873.A0A084VD32"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002816-RA">
        <property type="protein sequence ID" value="ASIC002816-PA"/>
        <property type="gene ID" value="ASIC002816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002816"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009999"/>
    <dbReference type="OMA" id="LIHWAYT"/>
    <dbReference type="OrthoDB" id="8188991at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002816-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="310" mass="35244" checksum="74E2123FC4905E8F" modified="2014-10-29" version="1">MAKEESKYGFKDRAKAEESLELLKAEDHKYQMLTVRGLIGRAKRVLTLTKAEEKVNNIKAAIETFEKWLEANNTASTKNAKPKEAEEKVETVPGLGFKDKQAAEQTLKILEGRDPDYQKLAIKGLLGSAKRVLPATKNEDKVKSIKEAMALFEDFLDLFDREERGKQNMPYLSIELIRQLPTPSQPDKLAADFLDCYETVAKGNYKHLRTKAPKDEQETWDIIRNRNLQKLKPKGDEKLFDSDGKPTETHLKLAQWAYSPQVEKLKSFAASHAKSKSNPRKRSHSTSDGEESNKSKDKHGKDQSNKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDV1</accession>
    <name>A0A084VDV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP003498-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Pep_M12B_propep domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003197</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011802">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524723">
        <property type="protein sequence ID" value="KFB36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDV1"/>
    <dbReference type="STRING" id="74873.A0A084VDV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003197-RA">
        <property type="protein sequence ID" value="ASIC003197-PA"/>
        <property type="gene ID" value="ASIC003197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003197"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015130"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="3">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="27559" checksum="5E53B881F823778C" modified="2014-10-29" version="1">MATHHHPRNGFSYSPALGLLRGLVCPLVQPQRSKTFNEAKGFEGGPEDDQRFHPSREFSHYGRVVPQLRHGRHKRSLIDTREANGLHASHLTLSYTLDEADVILDLQLNEQLLPSGHFLSYQLPNGTGKHVERYTRPEDVDLCHYRGKIRGKPDSSAAISTCGETGGIRGIIIDRDDTYYIESSAPFATEADDRASRIDLGEHFIYRHADLLPSGANGGHKCGYEGGHLNATHDPALYQELRDRGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEV8</accession>
    <name>A0A084VEV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011253-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003652</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524783">
        <property type="protein sequence ID" value="KFB36502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003652-RA">
        <property type="protein sequence ID" value="ASIC003652-PA"/>
        <property type="gene ID" value="ASIC003652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003652"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013064"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6219" checksum="F63AF8864A6BB564" modified="2014-10-29" version="1">MSSAGPGANSVPGSVQPTPAQYYPYTTLHGPDDVGYDANFHIFPPDYYASECDYRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFF3</accession>
    <name>A0A084VFF3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">STE/STE11 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003846</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003846-RA">
        <property type="protein sequence ID" value="ASIC003846-PA"/>
        <property type="gene ID" value="ASIC003846"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003846"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003846-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="11064" checksum="71C03C4A990EB463" modified="2014-10-29" version="1">MDVDSTAATCGLRACLFETESRRQLDPTTKAHRARPDCQRLSIRRVPEGTRCQPPRCARYEQPTGNASCHRVRHGPNIFFTPNRIDVSTVMCALHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG61</accession>
    <name>A0A084VG61_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00004132</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 24">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01012673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012675">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012676">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012679">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012680">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012681">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012682">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524808">
        <property type="protein sequence ID" value="KFB36955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG61"/>
    <dbReference type="STRING" id="74873.A0A084VG61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004132-RA">
        <property type="protein sequence ID" value="ASIC004132-PA"/>
        <property type="gene ID" value="ASIC004132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004132"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001133"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004678"/>
    <dbReference type="OMA" id="GHAKNGH"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase RgtA/B/C/D-like" evidence="20">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="19">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="726"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="876"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB36955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113823" checksum="C17B2F3EC89FD2C5" modified="2014-10-29" version="1">MLQNDFWGTPLTDSGSHGSYRPLCVASFKLNYLLDGFKPFGYHLVNVLLHSLATGLVVKLARHILPAARSGAAVAGLLFAAHPIHTEAVAGVVGRADLTGCIFYLLTLLAYIRHVRWRQWGDGRQWLALVATLLLAGAAVLCKETAVTALVVCAIYDIIKGYAGSRDKHRARSIGILALALAVIVHCRLTLPRPATLFSSADNPTAKSGSLWTRFLTFTYLPVVNFRLLLLPDVLSFDWGMDAIPRISTVFDRKVALAGCFYALLGYALWASGRALRQQARASVSSGGKGSGTLHASTSSFNRKLASKLTLHRLRAEGPAVLATGEPEGATCALCKHDIGLRHSVPCRTLHNNNGLSSIMCGCAYAPACKYLSLSPSTLSNYFWRPVPGDAGAVGPTGTGSSCKSIAPFCNNNDSASINLNQGFPGTMTKKFACHWPLAGTPAGCQDKFPFSSCASSVRGDSPDASMDENRSRGTLDNSPSAALLMSVALLTLPFLPASNLLFYVGFVVAERILYLPSVGFCLLVGLGVSGLTDGHHQSSRPSSGSVSGGGGGSGGGKQHSIHRNHVRRNASGGGGSFVRKWWTGVVQGVVRGVCVGDGECATRGSAVGSVHDSAANGNRIIVSDNGAHGASGGRFSKHRHSGIVSAGGSEGGASGGGPGKTRPTVPGRSGGQRNRSAKAANRRRQLVLVCVGVLLVAYSAKTVHRNRDWADEESLFRSAIAVNPPKALGNLGSVLSAQGRYQEAKEALKAALSHRPNMADVHYNLGILLQNQQDYNEAVESFRKAIRFRPSLALAYLNLGTSLIALGRCQEAASVLREGSKLDGTGLRDRAAHENARISALLQLGNLYADQGKLQRALAVYREALHSLPERYPPQGIYHRLGDVFARLNQWTEAERFQRAALEAQPDHIAAHLSYGTMLARNGSRTSEAEQWFRRALRLAPDDASVHHHYAEFLSAQRRPEEAFQYRVRAAELAPEDYALVVAAASSLRLHDRKLEAERWYRQAVKLRPQEARAHTNLGAILHLLGRSQEAASSYREALRLQPDDLTTLSNLAKLGVPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGC1</accession>
    <name>A0A084VGC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004199</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012766">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524813">
        <property type="protein sequence ID" value="KFB37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004199-RA">
        <property type="protein sequence ID" value="ASIC004199-PA"/>
        <property type="gene ID" value="ASIC004199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004199"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021486"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="6845" checksum="356D29D70DC2FDC2" modified="2014-10-29" version="1">MAVVGDVENNGKAGVQGEADGVKLPLGGWVESLKLPPVVNLAAPDGKKRAAQGGGEDVMSLNYGAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGD7</accession>
    <name>A0A084VGD7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004213</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524818">
        <property type="protein sequence ID" value="KFB37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGD7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004213-RA">
        <property type="protein sequence ID" value="ASIC004213-PA"/>
        <property type="gene ID" value="ASIC004213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004213"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="209" mass="23240" checksum="29626C72BD1BE05C" modified="2014-10-29" version="1">MQRTFNDNGHKGARKQGLDGINKICTLLRFCEPFLRSVVTACLSAKPISRPTRHGSPGRVENTLRKEKDNRAEYSGIHFCERRRSAGPLPRSGKARKIGKPFPRGLPRVTGGGRPEPYTRPASVAAGRELNARALATDCQTLDGWQKSLAAYSECLPRIRRPRGGFVGFGYESAVNKHAHQGVLTCGKRCRHVRPRLMLNPKSDKLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHB6</accession>
    <name>A0A084VHB6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Aldehyde dehydrogenase family 1 member A3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004655</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004655-RA">
        <property type="protein sequence ID" value="ASIC004655-PA"/>
        <property type="gene ID" value="ASIC004655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004655"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000205"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004655-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12785" checksum="55438E90275EEDBE" modified="2014-10-29" version="1">MAYARFVLIHIRNQWHSFDHHHHFPTASSSSSETSYDKPHGNDDPVEKATCRLRIRPVLLDTGSASVPGRLGKGESRMAGCSPDRILEHLFAHIPQAHLMNDGFGETVKWEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHI6</accession>
    <name>A0A084VHI6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear protein localization protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHI6"/>
    <dbReference type="STRING" id="74873.A0A084VHI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004563-RA">
        <property type="protein sequence ID" value="ASIC004563-PA"/>
        <property type="gene ID" value="ASIC004563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004563"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004952"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015589"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000012">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="271"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004563-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="658" mass="74572" checksum="3B3934FA8EC0594A" modified="2014-10-29" version="1">MANYIELDVKSNAWNVIIVPNETRQSVLRIQSADGTKRVETEPAATARNLYELVRTAYGFDHFDFALFRERNFTKEIVSSGSQDVKDIGLKHGDMLYLRLVEGPSTSKAAERSASASSLASSNSSSISNVAFSREATPSTSAKSLSVVPQLPKEDTVDVELYNQDGRIKRNRDEKLCRHNSNGCCVHCSPLEPWDENYLKEQKIKHFSFHSYLKKLTSGATRGKFVALEDLNCKIKSGCRDHPPWPKGICSKCQPSAITLNRQPYRHVDNVMFENTGIVERFLNYWRTTGHQRIGFLFGTYEIHPDVPLGIRARVAAIYEPPQESNRDSIRLLDDANDGDVDELAKALGLQRVGWIFTDLLSENLASGTVKHVRNIKTHFLTAQECILAGHLQNKYPNRCQHASNGYFGSKFVTVCVTGDDKKQVHMEGYAVSGQCMALVRDNCLIPTKDAPELGYIRESTDKQYVPDVYYKEKDVYGNEVQRLGRPLPVEYLLVDVPASTPLVPLYTFHERKDAKEYFPVENRLIDGHIQDFSALADYLAKSRSMPFLETVSDFHLLLYLYRMEDMLPMKPQLGPLLEAVRSKDKAKANEWKTREVWKTLEELIAASSHHEDSSMSNDVEFVPSGDAEQNWICTYCTFINSRELPACEICNLPRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHS2</accession>
    <name>A0A084VHS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004749</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB37516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC004749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004749"/>
    <dbReference type="OMA" id="PPCFRCK"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="13684" checksum="70E59DC5F019E7BC" modified="2014-10-29" version="1">MPVACMYTSPQDCPPPPCFRCKRWNNXXXXXXXYATSYNAHTVNHNIAAPYVAATPVAAAAVAKYVAAPAAPVAAVAPVAKYVAAPAYTTAYAAGAPVLPAAAAYTAYTAAGAPVLPAAAAYTAYNAAAYPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHX8</accession>
    <name>A0A084VHX8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHX8"/>
    <dbReference type="STRING" id="74873.A0A084VHX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004809-RA">
        <property type="protein sequence ID" value="ASIC004809-PA"/>
        <property type="gene ID" value="ASIC004809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004809"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005925"/>
    <dbReference type="OMA" id="QFNDVLW"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783530" description="ER membrane protein complex subunit 10" evidence="9">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004809-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="231" mass="26086" checksum="A098B23C4CDFCF50" modified="2014-10-29" version="1">MNLLMKITLIVAVLSVNIFNYVKANSLEYDGWLNIALYHALDYDEPNKFTLRGNVTVTNRNSGLVSVAQEPLTLQDRNKLKRLAQENRLYRLEAHVSDSNGVTKFLTSSKACALAKAQLTDVLWVSLDHSGTVTAVTQSVNNGNMDHCRDLSNSDIDVLDEFNTDVYVKHTENAPIPDTASFIQKMEREREARERGDTKDNRSFFAKYWMYLVPVVILVLISSTNPEAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJG1</accession>
    <name>A0A084VJG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000987-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00005380</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJG1"/>
    <dbReference type="STRING" id="74873.A0A084VJG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005380-RA">
        <property type="protein sequence ID" value="ASIC005380-PA"/>
        <property type="gene ID" value="ASIC005380"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005380"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004281"/>
    <dbReference type="OMA" id="NCINGRE"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF110">
        <property type="entry name" value="LD43683P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783689" evidence="6">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB38105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005380-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="27858" checksum="CE386F71F01217AD" modified="2014-10-29" version="1">MSNRVLVVIFPLVLTVALLCSAATDDSDDYFEFTCPKPDGQFEDPFQCDRYYECNDGRVSEKLCPDGLVFNPDSKLVNKCDQVFNVNCGNRKELQPPRPVGGCPRQNGFFPHPDPSICNIFYNCVNGRELEMTCVAGLHFNQPTGTCVWPDMANRQGCGSNANKKLNDGFQCPKNAAKMDKNGQAITHPNYPHPEDCQRFYICLNGIEPRQGTCDDGMAYNEDLQRCDDPENVPGCEDWYSLPETDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJM0</accession>
    <name>A0A084VJM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Palladin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005466</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524889">
        <property type="protein sequence ID" value="KFB38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005466-RA">
        <property type="protein sequence ID" value="ASIC005466-PA"/>
        <property type="gene ID" value="ASIC005466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005466"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014272"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="23089" checksum="31855802E71AA8E1" modified="2014-10-29" version="1">MEKYSLGWLQQQYPQFTVTAVDQPAPPQQATVELERTDLFAAAQYLQQNPEVTITAVDQHAPPEASTVSSAAAGLDLARLEAQSWPPTPPSSPPVSSLQCLSPATNTASSGLYNADLARQLARMDEKLDRLRHEHGVTSVMLEMSVERLMIDRSVCSHFEFVHLETREKMREFEEKLGQDTAYADAMVDQLKGANFRGMHLDWAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJM1</accession>
    <name>A0A084VJM1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005470</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013772">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524890">
        <property type="protein sequence ID" value="KFB38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJM1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005470-RA">
        <property type="protein sequence ID" value="ASIC005470-PA"/>
        <property type="gene ID" value="ASIC005470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005470"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005470-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5702" checksum="C1AA4348C7C5631A" modified="2014-10-29" version="1">MHVVGTRRRNGTAALRRECEDECERQGGPRSPVLGGLWVGADRVGGLVGTRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK44</accession>
    <name>A0A084VK44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein CEPU-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005691</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005691-RA">
        <property type="protein sequence ID" value="ASIC005691-PA"/>
        <property type="gene ID" value="ASIC005691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005691"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020922"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005691-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10282" checksum="2008367B5FCC9B9C" modified="2014-10-29" version="1">MSEWLAGGTSLEFYGLFRGSSEETEQQLKDEKSETKDFPRPGALLLDVGWLAMPRPMLLEDRMKITVKQCEMVACCARAVDLGRQMHLGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKA5</accession>
    <name>A0A084VKA5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Diacylglycerol kinase</fullName>
            <shortName evidence="13">DAG kinase</shortName>
            <ecNumber evidence="13">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00005758</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01014172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VKA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005758-RA">
        <property type="protein sequence ID" value="ASIC005758-PA"/>
        <property type="gene ID" value="ASIC005758"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005758"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012436"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013164"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016491"/>
    <dbReference type="OMA" id="TCKDLWK"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20804">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20854">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17111">
        <property type="entry name" value="RA1_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01783">
        <property type="entry name" value="RA2_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000004">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000200">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000058">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000011">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056392">
        <property type="entry name" value="DGKtheta_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24099">
        <property type="entry name" value="RBD_DGKtheta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="716"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="17">
        <location>
            <begin position="806"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="326"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005758-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1356" mass="150942" checksum="346C4605FE05191A" modified="2014-10-29" version="1">MAGGEHTFGRKTFHKPTYCHHCSDLLWGLIGQGYICEVCNFIVHEKCVSNIVTPCTGVAPYLIRNPVAHCWSEPSHHKRKFCSVCRKRLDETPAVHCLICEYFAHVECQDFAIPDCKENATYVPGKELGHVKHQHHWREGNLPQSSKCAYCKKTCWSYECLTGYRCEWCGTTTHGGCRNNIPAECTFGTLQPIYLPPHAVSIPRTEVPMEAIIGVQNRNKGTPGIQRDYSCPELWTIGMYQEELQEQQKRQHACTSESTELLLRRVQQEEQERKCSTGQLSPGVSFTFYNDDDDGGGSMASGSQRRAHTELTQQLYHSDNSLTLLQQQQQQQQQLHQPKPLDGQEDEWPMRPARSRNLIHPALRRAKATNQTGGPGDATTVMRSRSFQDQTDSIPKRLTKASVAPGYSPRFLARFRKKHQAPPSPGGRRSPSPPSGEARGSFEGGTGVSRLFTHSPGAGGRRGSTAMGPIRAALAPVFLHGTSSSLTSSSVVCSSGPLLTVSGVNGNDDDDDEEDDLSPPLGAPVERSSSFDCTAQAAMAVAAAAGTIRNVGHHLTVALEPRRVVSYDDVSEFGFIDDDDGSNAAAVASDSLALHQTKRTPADECRSALADPMVTPAGAAISQARDLGLSQSAPSQHLLGRIYRRMRKCSMGWSKTGCRVRRARSISEEITAESRYRDEEYVVRGEGSSSSGTHSKPDSAHKPDKDKDKKDKEERDEETIKVFDGNCSYRRRIFRAISVPRTCSLEQLLTTALRAFHIARDPNLFFLTDVYGDEVRLQEPNPVPSLHRVEGKRPAIYLRFRDKENDHGFVRVYPGKLQVENAYVIIPVDNDTTVKDLICESLKKFGLQSHQIEDYRCSEILLDRGVTERVLSWNERPWEIMKQLGKDSIRQMELMRFYLQLKQDPHGPNLALFVGNLPPGLSQRNYEHILTEFLGFENKFSSIGPIYYEYGSLVITYENASKAVRAFQALRESKYEEKHLLVLLLPNIEPSMVPPGVQPLLVFVNVKSGGCQGLELISSFRKLLNPYQVFDLDNGGPLPGLYVFRHIQDYKILVCGGDGTIGWVLQCLDNVGQDSECSSPPCAIVPLGTGNDLARVLRWGAGYTGGEDPLNLLRDVIDAEEIRLDRWTSEDNSQIFVMNNYFGIGIDADLCLDFHNAREENPNKFNSRLHNKGVYVKMGLRKMVGRKMVKELHKELRLEVDGKVVELPPVEGIIILNILSWGSGANPWGPEKEDQFSKPNHWDGMLEVVGVTGVVHLGQIQSGLRSAMRIAQGGHIKIHLHSDIPVQVDGEPWVQSPGDVVVLKSALKATMLKKMKGKMKRRNTEPTMQVMGPSGIQMTLAAPQEPDEVDSNNTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKS8</accession>
    <name>A0A084VKS8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005946</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524949">
        <property type="protein sequence ID" value="KFB38572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005946-RA">
        <property type="protein sequence ID" value="ASIC005946-PA"/>
        <property type="gene ID" value="ASIC005946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005946"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7887" checksum="EC24B330C24060D7" modified="2014-10-29" version="1">MSQRAAYGSERCTVAERLILHWFISIATEAIRWENTIFNLERTYRMRSIDPFKIGFANERLGIEFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL37</accession>
    <name>A0A084VL37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008474-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL37"/>
    <dbReference type="STRING" id="74873.A0A084VL37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006076-RA">
        <property type="protein sequence ID" value="ASIC006076-PA"/>
        <property type="gene ID" value="ASIC006076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006076"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020751"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006076-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13804" checksum="AC0D7777298E569E" modified="2014-10-29" version="1">MGQVKSQFSEDELQDYEDLTYFTKKEILYAHKKFKNLAPEKVGHNKNAKLSMSKVLEYPELKANPFGDRICKVFSSSNDGDITFEDFLDMMSVFSDAAPKSVKAEHAFRIYAPSAFDCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLT4</accession>
    <name>A0A084VLT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000469-PB-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N_BRCA1_IG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006250</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014551">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLT4"/>
    <dbReference type="STRING" id="74873.A0A084VLT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006250-RA">
        <property type="protein sequence ID" value="ASIC006250-PA"/>
        <property type="gene ID" value="ASIC006250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006250"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008096"/>
    <dbReference type="OMA" id="HWQGSPN"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000111">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="1">
        <location>
            <begin position="86"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="26207" checksum="FA6B8F1A66184E80" modified="2014-10-29" version="1">MDNSEEQASSTPDDIEQNFLMQFSSMVTTDKEELIKQFQTIGENLNSNTATFFLDMSNWNLQAAVGCYFDYMARAQLSMKLVKDNTIGQGEKIPPNTAIKLTWLVQNNGEVAWPSGTYVGLKRPPNVIPNLSTLSYEDLKFYVPEVLPYRTTTISVQLVTPAQEGAFETVWVTYDPNGTSFGEEIVSRLEVSLDGTMAVTQQLYQENFRHNASNFEPAPDNYIDYTEENMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM42</accession>
    <name>A0A084VM42_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006747</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006747-RA">
        <property type="protein sequence ID" value="ASIC006747-PA"/>
        <property type="gene ID" value="ASIC006747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006747"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9027" checksum="4BCBDBB3E2E72650" modified="2014-10-29" version="1">MQPSREQHVQDFLLKEDDALPPPSLALLSTALATLVDSARQTAVESPPDAQSLDRGPSGVEDELEVVASPALIVHCICDFFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMS4</accession>
    <name>A0A084VMS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP008778-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00006619</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMS4"/>
    <dbReference type="STRING" id="74873.A0A084VMS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006619-RA">
        <property type="protein sequence ID" value="ASIC006619-PA"/>
        <property type="gene ID" value="ASIC006619"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006619"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015361"/>
    <dbReference type="OMA" id="ICQINTR"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006619-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="294" mass="33334" checksum="8D8BA1B76C8338F9" modified="2014-10-29" version="1">MPTSSRARKTKRTYARTEASFPRFAEPIPNITVTIGRDALLACVVDNLKGYKVAWVRVDTQTILSIHHNVITQNPRISLTYNDHRSWYLHIREVEENDRGWYMCQVNTDPMRSRKGYLQVVVPPAIVESMTSNDMVVREGTNVTLNCKAKGFPEPYVMWRREDGDEMAIGGENVNVVDGEILHITKVSRLHMAAYLCVASNGVPPSISKRVQLRVQFPPMLSIPNQLEGAYVGQDVVLECHTEAYPASINYWTTERGDMIISGKLNLNIRVTNSPGENRSRLMKLIPQLDSYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNG1</accession>
    <name>A0A084VNG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">FRAS1-related extracellular matrix protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007002</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007002-RA">
        <property type="protein sequence ID" value="ASIC007002-PA"/>
        <property type="gene ID" value="ASIC007002"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007002"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007002-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13949" checksum="F29E9F539F9B409B" modified="2014-10-29" version="1">MAVTESYDGNRASKIRINIVCLPFLARPPTPFVNPSVVSEEKADVHMSADDNTRPPLQKPTTKKGYAPGWQTVRLCLIFHSQPFNGRFGIRSPSHRYTVRTGVLQLILMAIGMTVSWCAMEESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPR0</accession>
    <name>A0A084VPR0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009460-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007337</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPR0"/>
    <dbReference type="STRING" id="74873.A0A084VPR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007337-RA">
        <property type="protein sequence ID" value="ASIC007337-PA"/>
        <property type="gene ID" value="ASIC007337"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007337"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023609"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007337-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9927" checksum="EB8DB79EC0983BDB" modified="2014-10-29" version="1">MLAFDPMERISVDEALFHPYIHLWYSEKDVNRPAPAPYDHSIDAQNLTVQQWKALLYEEIRDIQQTMTLDEAPSPSGAVDPAGEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ06</accession>
    <name>A0A084VQ06_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007510</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01015102">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ06"/>
    <dbReference type="STRING" id="74873.A0A084VQ06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007510-RA">
        <property type="protein sequence ID" value="ASIC007510-PA"/>
        <property type="gene ID" value="ASIC007510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007510"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022744"/>
    <dbReference type="OMA" id="NNYDFIC"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="309" mass="35524" checksum="F161362665B3226C" modified="2014-10-29" version="1">MEDKATLKDLDQWIEQLNECKQLTESQVKTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNPNVWKFFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISELFNHTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDALKFSFLQFDPAPRRGEPHVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQK0</accession>
    <name>A0A084VQK0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dgri\GH14341-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007624</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007624-RA">
        <property type="protein sequence ID" value="ASIC007624-PA"/>
        <property type="gene ID" value="ASIC007624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007624"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007624-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="7914" checksum="5B05B522861C14D0" modified="2014-10-29" version="1">MAMLDAVQASTTGMDPPVYREEEHVARNTSVSFGIVMAIVIPVALIVLLIVRYKIRQGQKRSASKSKAGSNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQS0</accession>
    <name>A0A084VQS0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007802</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQS0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007802-RA">
        <property type="protein sequence ID" value="ASIC007802-PA"/>
        <property type="gene ID" value="ASIC007802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007802"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017337"/>
    <dbReference type="OrthoDB" id="7724957at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783981" evidence="1">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007802-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="182" mass="20038" checksum="AB857BBCCD9BB8FB" modified="2014-10-29" version="1">MVPSRMLLVIALGFTLGVEAVLAKNATTPGECTMVGAKNPRECCRSFMELHDAIISCLPKPGSTGTVCIAQCILQGYSLRPLGSSVPLSLSRVITYGPKLAAHFDECKTDLLDFLQGNMFQGDLQRVVCDERVNRFFVCMVKSWFQDCLGFDDSVEKCNEMKEKVQSGSCDISTFFELSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR26</accession>
    <name>A0A084VR26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP011312-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">CortBP2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00007898</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525013">
        <property type="protein sequence ID" value="KFB40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR26"/>
    <dbReference type="STRING" id="74873.A0A084VR26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007898-RA">
        <property type="protein sequence ID" value="ASIC007898-PA"/>
        <property type="gene ID" value="ASIC007898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007898"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001078"/>
    <dbReference type="OMA" id="CATPMVN"/>
    <dbReference type="OrthoDB" id="6021133at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050719">
        <property type="entry name" value="Cortactin-Actin_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019131">
        <property type="entry name" value="Cortactin-binding_p2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166:SF5">
        <property type="entry name" value="CTTNBP2 N-TERMINAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166">
        <property type="entry name" value="FILAMIN/GPBP-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09727">
        <property type="entry name" value="CortBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cortactin-binding protein-2 N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="150"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="681" mass="74093" checksum="4E843BB8FACF6748" modified="2014-10-29" version="1">MAEVGTSSSGDGESAAPDKPKGTVKFTDADLAAIKQTSDTWKRNPKMDFSKADLLKLLSYLEGELQARDVVIAVLKTEKIKQLLTTPRYSKSTNLNDPHAALFRDQLAASGNIASRQSSFQAAHSEHEMRLINDQRSSVREQMDSLATLVMQQRQAQAKMIEALKDAEERHKRVVQELYDERRKHEHTTAQGDDITYGLEIERSRLKQELDHEKEQHKALEIELRKVQEQFEAEKNRQKQIVLLLLAERKKIIIKYIEERKRSEDLAQILSEEKQRVDTIAEGLEEESKKSLRMEAELEKQAQVFEVERKMLHQSLAKEEKRVKEQEVEIQQLKAEIELLRKQTGIRHPLVAPQLPTKPGGLVPSRPSIAGGVLPGQMISSMATKVVQPTATVSSVPVSAPTTGIARSVSPGQLIRQTAISQLSVTAPPIVGGTSSPVAPAGPGGSPAGTTPSETYANTTGKMASTGVRKAAGIAAATVIAGGAGAGATSPATTNPSAGMSGSTATMKKTIIPPVGGRGVPPPIPPNKPQIPPKLSGVSAVAAVAAGAVSAPLPAIMLARTRQTPHTIIRFLCHICTQIILTLIIPSLMPIRQPVRPGVLPVPFRRPPIMLSPLLQLPVPSLELSPPQPPQTQQQQSACPQQQQPPTQHPQQSLPNHKVLRRQPHLPHPFHQPPQVGHPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRL6</accession>
    <name>A0A084VRL6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongin 15 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SIII p15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00008120</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (CUL2 or CUL5), a catalytic subunit (RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1, ZYG11B or RAB40C. Interacts with TMF1. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015746">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRL6"/>
    <dbReference type="STRING" id="74873.A0A084VRL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008120-RA">
        <property type="protein sequence ID" value="ASIC008120-PA"/>
        <property type="gene ID" value="ASIC008120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008120"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016505"/>
    <dbReference type="OMA" id="AMVSPII"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000016">
        <property type="entry name" value="Transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="16">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB40610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12884" checksum="7E83AB21692ADE49" modified="2014-10-29" version="1">MEERTGTERVYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENEANEVNFREIPSHVLEKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRM4</accession>
    <name>A0A084VRM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008129</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015748">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008129-RA">
        <property type="protein sequence ID" value="ASIC008129-PA"/>
        <property type="gene ID" value="ASIC008129"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008129"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759876" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008129-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7114" checksum="75DD928B71092595" modified="2014-10-29" version="1">MIAGLFAGMPGGFLLNFSLLVSNVAAASQPLIRRNDSALGCRLVCGLTTVSLKRGFSTPQDLKAQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRN0</accession>
    <name>A0A084VRN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP001809-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008144</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRN0"/>
    <dbReference type="STRING" id="74873.A0A084VRN0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008144-RA">
        <property type="protein sequence ID" value="ASIC008144-PA"/>
        <property type="gene ID" value="ASIC008144"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008144"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018862"/>
    <dbReference type="OMA" id="FIIRRDY"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000233">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB40624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008144-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="568" mass="64071" checksum="696AEB0FF7E53D41" modified="2014-10-29" version="1">MLSALTTLALHQRLRKYILSRTKSESAKGNRGSAGTGNSRTVTIPSFEEFLLKRDYVGANTVLQRSKDYDEVPELLKQLWTGFCDFHIGEYKRALQLYEKLYAADNSQKEVALNICVCMFYLGMYDEAQKLVEELPQSPLKIRLLFHLAHKLGDEDRLMELHGSLRDVVEDQLSLAGMHFLRSHYQEAIDIYKRVLLDNKDLLALNVYVAICYYKLDYYDISQEVLDLYLNQFPDSTIAINLKACNRFRLFNGRAAEQEIKHLVESGTFGADLIKHNLVVFRNGEGALQVLPQLIDIVPEARLNLAIHHLRRGEIQEAYHLMKEVQPTVPQEYILKGVVHAALGQETGSKEHLKNAQQCLHLVGGSASECDTIPGRQSMASAFFLYGQFEEVLVYLNSIRSYFVNDDIFNYNYAQAKAATGYYKEAEELLLQIHDISIKTDSTFAMVLAKCHIHAGHADQAWNIFLTKDSTPDAFALLQLIANDSYRVGEFWIAAKAFDTLEKLDPNPEYWEGKRGACAGAVQAILAKRGSGAPPGGVSEIISLLRDSTNTQAEGMLRVIRRFASSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRQ2</accession>
    <name>A0A084VRQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP001826-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008261</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VRQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008261-RA">
        <property type="protein sequence ID" value="ASIC008261-PA"/>
        <property type="gene ID" value="ASIC008261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008261"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011533"/>
    <dbReference type="OMA" id="MTWTILE"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF36">
        <property type="entry name" value="APOLIPOPHORINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783875" evidence="4">
        <location>
            <begin position="26"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="5">
        <location>
            <begin position="43"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="2754"/>
            <end position="2918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="3330" mass="366449" checksum="8A763E12F6BDDABD" modified="2014-10-29" version="1">MWVSSGRSLLWGFLVSLVLFQSVFAASCKSGCPTPNKSTKYNFKPGTVYSYDVDSYVQIQQADKAADKQTTLKVEGKVELYAGDNCQYTLKVVSLTSFAPDGKKTAFGAEISKPVRFTLSNDELLPEICTEADDTDFSVNVKRGLISLFQSAQEKSTETDVFGVCQTSFSSYTADGATVVDKSRDLSNCAYRESLSNSFVTRIVNSKAGIKSTPLLQSYYNNQQTFKDGLLASVKLGEEYQYLPYLKDKVGVTAKVTTKLTLTGNKAGAAPAAGNEPRSIIFENPDQQPTNNLANIKQELRQTVESYTNGNVGKKTANLFVELIQLMRYSKKEDLLALYNQVKAGSVHSNKDLTRKVYLDSLFRVGTGDAVEAITQLYKNKEITDAQEVKLAFVSLNLVDSMTHSALKAVNKLLEGNPPREAYLSVGSLVSKYCQKHGCQSADVKEISNKFASKLGKCQAGTRSQEDVLVAVLKGVRNSDNLVAPLLDKVVQCTGPDASSRVRVAALQAFPAASCNKKVVNSALATLKNTNEDSEIRIHAYLSLVECPSANVANELKALLDSEKVYQVGSFITSHLASLRSSVDPTREAARQHFGKIRTSNKFPFDVRRYSFNRELSYAVESLGVGASADTSVIFSQKSFLPKSVAVNFTAELFGNGVNVFELEGRQDNLERLVEHYFGPKGFFTGMDMQTAYNTLFQQYQKMSESAKARFRRGIREDVRGLAKNVNLHNDALQDFNLDLTVKVFGSELFFLSTGENLPTNPEQFLEKALELFDKLVEGAKKFERTFEHHALFLDTDLVYTTAVGLPLKLSAQGAAVARLDAAVEVDLKALVQDYTNAKFNVKLQPSGSFEVTGTLSVDAFNVLTGVQVAASGHSSAGAAVNFALHGASAYDLTVDSLQTKQELVSVTFREVIITRERGNPLITLPAKRNDVGTKFSECFDNLYNVIGVTVCAAHKVQGQEEVFEAYLEVEPKFQFSGKFDNSNPRHVTLQMSFDTPGSQTKRSTSLLLEGVTGGDLYVKATLDSPFRKVDFQLGANYNDKEVALYALAHNGMEEYLAKVGFERGSAGGREEYVPIFTIRSPSGDAQVSKLVQTTGKIVVESLGGDKRKYLLQNIEWTSPYAPKTTINGQVVSNGERNYDADVDVTVGETKNNVLGHLDFDLKHVKLDLEKKTPSDANKNFKVNLELAYTENSFKNLFSFASGKDFNNPSNKYELSQLAEFTLKPEAKGLESLKLYNKLQLPKQLIRLDFATNKNKFFLDGEYGYDKYKIAANVDAKYNEKSAGDYDVQVGASLNKHFFKFFSKRVVEQNKSRFSNRLTASTGTKFELNGAVTNRFSTQDGELNLDGTLVAVEKASPYKLSLTVQFSAANVVSNAKVLVDKAEFATYDFKLERGNDPNGKFSFVVKDFFDGNGELKSTKGQGELFAVANFQKQDRKVKLDSKFKVSAPVYDVSVDLYYDFEKDNSKKVHFETKNKATQTSFDSKNKVEVFSEKYEFNVQGQGNPKPVDGTFTTKFNLVLPTGRQFGGDFKRDASTKDEKKFGKMVANLFDKQPGGKQRTVQYTGELKDGNFKAKLFDATHNVKYTDLDGKTLVLGVGMKHVPAGSYRSAAGSLKVSGSLLPQVAEVAVVVDEYCEHHAKYHVDSKYGADFGLNLVGGYQTGGHGKPASHELKVDVTAPSVKLGATSNGKYLQPETDDGVFDFEYNGSFDYNGQKASVATQAKGNFNRGNGKLNLNFPNVDPIAAEGSYTYDGKEDGPLSTNGALKVTYGQGKNFEFTGSAKVPSSDDVQVHVTLKSDFENVRSVDVTFKHAKSAVSAYNTKLQVTADGKKFSVENAVVLSESNPSVDFTLAYPDKTVKVSGSYKTLGHSAFKADAKVQNLANFDMEANVEANFDSYQTFYFKLYGDAPMLKTNKFSVEVNAKPGSNGKGVNFRASEGGKDILSGYADYSVKEQGKATVIEGQGNVKLYDKQQTATFKLVREKLADSGFSASLTASVGKLSATHEVRVQPNDFKLKTSVCDEKKKCTKLEILSKLERNAGAFNHEALVSVDVQQYEHEFGLSAKTSANGFKFDHTTDVQLKEKNQPKYQYLFYVHPSSAGASLILPTRTIAVEGLLTLPKEKFGLFDGSVSVYLDKKNEPNNKATFALRGETKMLGSAGVSANGALTFSHPTIKGLSIRAKGSLDGDKQTADGSVEFDVFKKAADKLVASVRYANSDLSYKGFNITTDASVSSKGLGLNCGFNGHYALSLANRQASAAGSLTLPFEGYTFGSYFFGSPEAFDFLLTRFGDEFVRAHGSYDAKKYRGDFTSTFKFVPTRPVVFESQLNGLSSAKFSFKQDQFFSADGTFGVDKAVVLNVVGEGKPLLNAKVTLDASHFLSTEYKVDEANAKLFLQSLNKQLQTDFAVVKDDVTQRYAKLTQDVSTLSSKVMDALPDFSKFQQSYAAQLQKLQQDVMSDPALAEFVNQVATVFQSLSEVFGQLSQVYIETLRKVTAIVTDVFGKLMETFNTKVLPALQELSTKVEAIFFNIYEETVKLLMAVFERTVKALKVFEEDFNKIANNVSELFKQFAQTFSKAIQVLEKEFKDLYKLVQDYFESFDEFKAVKETFKEYFDGADRYAYQLLRELLTLVEAVYPMPEVQELTTAINQYVTSKLENKPVNDVEELKKLFVSFVKVLHQAVERLISNVNLQLAEPTFGSESFTSFFTFKFLPYVSSVQFSPWNFFKNEKFYSVRDLIHQLRLYAFNPFANVPLFHMHGQFADGGHFFTFDDKHFTFPGSCSYLLASDFVDGNFSIVADMDKGVLKSVTLVDKDSTVELNSKAVVKYNGKETDLPLYQKDVYVFRRYYTVTMGTKYGAQVMCTTDLKLCHFYVSGFYLGRLRGLLGNGNYEPYDDLALPDGKITTVSTDFANNYKTSQACAAVADHGHDSHEHSNPTCAKFFGSESSLKMCSYLRDQTGYKEACNHAAHDAGDKADEAACGIARLYVSGCRLYGIPASLPSQCEKCVGDGGNQIDVGDWFSVKAPQKKADVVVVVDTALGTLLGELVQATINDLRKELKATGVSDVNIAVIGYSKTNKYTSLFSNGGKLDYTGKLGQADVNSGPQQCKALVTGFPDVDAVLEQLHNAGEVAKENLGTTSEVYALRRAFTYPFRATASKSVLLFRSEAFEDARPGTAISAALGLANVKARGILFNIVAPLKNVGLSNTKDQSKVKSIVGFNERVVYHTNDKKRTVGSAEMKKSLKYDDVVGVTGVERAGGNFFVLQNYSQQKAGKEKKQFISIVAAVLADQFSRTETTNDCVCYLRSGLHPETVCSASDVQLLPPSKKAGGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS44</accession>
    <name>A0A084VS44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP013075-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008219</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015804">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS44"/>
    <dbReference type="STRING" id="74873.A0A084VS44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008219-RA">
        <property type="protein sequence ID" value="ASIC008219-PA"/>
        <property type="gene ID" value="ASIC008219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008219"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001803"/>
    <dbReference type="OMA" id="HANPLTH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="498"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="500"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008219-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="619" mass="67568" checksum="CEFE0536539CAE76" modified="2014-10-29" version="1">MIHHQPTKYHHANPLTHFLNLHTSHATAAAAAALALASDAGLGQHHHGHHAHHGHPVTGTHLHHHPSSSPHQHYQREMEGQRQHREDFGAGVGYRGKTCKFESQTDEDEEGQDDSSNERSCAGERKHRFDRGSEKEGQEELSESENNVDIDVDDREPGENDDRGIDQENGTEKCRTSNNLREQAFSKERVASSDVEEEEEEDDEEIIIDGKGSKDEGDFRDGEENMDRNNHAGCASPCPNEANTAVLETDGFVGKSFTIAAILGLKKKQDEAAAAAAANEYSDGAMNLSTGATFQPQQHQQRAAAAVAVAAAAMGRLPLVMAAMEKRERADSVDSADACGGPLGYGVRPLSAGQHQPGATGGGALTALQSLHQLPGLHGTGGGFSAFHPSSGGVGVHPNPHQQHQHHPGNHHHAHHHHPGFGAIIIFITFRANQLRNIPNSSSRNNNNSTRINTNHYIFSNIPHISNNSSSNSTLLTDIIWHWGHIIIVKIIAGISLKLERLEAEFERQQYMVGPERLYLAHTLQLTEAQVKVWFQNRRIKWRKHHLEITQQRLAMIRQRQIANGVPIGATPGPQAHLGQPAQAQGSMSGGRMVNQIDSPDLTICTDSMDARSASEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSE0</accession>
    <name>A0A084VSE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008411</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008411-RA">
        <property type="protein sequence ID" value="ASIC008411-PA"/>
        <property type="gene ID" value="ASIC008411"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008411"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008411-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="172" mass="19034" checksum="861896A4F1934330" modified="2014-10-29" version="1">MEGTEGSRTFSVSVVCDDASEPFRTESSMIAMGEGKMRVPRRAAVQSLAKKGKRPTRGCRWSEEATDSNPDETISVGFFFVLRPTVAGSGLSVVSIARGSSVSQHSRHCPARRRRWIERESAVESISAPIDNAFIRCTFEPQGSIIVSEMRKVFPRLVVALREEEGLVRNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTB5</accession>
    <name>A0A084VTB5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP002752-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016288">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTB5"/>
    <dbReference type="STRING" id="74873.A0A084VTB5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008774-RA">
        <property type="protein sequence ID" value="ASIC008774-PA"/>
        <property type="gene ID" value="ASIC008774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008774"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004439"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000659">
        <property type="entry name" value="AGAP002752-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000015">
        <property type="entry name" value="dnaJ homolog subfamily C member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783769" evidence="7">
        <location>
            <begin position="29"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008774-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="488" mass="55712" checksum="8CD36B11A7108085" modified="2014-10-29" version="1">MSQLADSRRLGTVLLFLLIELFFKGAETASQAEIDRHLEIGRDFLARGQLSDALTHYHAAVEGDPDNYLTYFKRGTVYFALGKAKFAINDFSRVLELKPDFMAARAQRGSVYLKMGDFENAEMDMMVVLRNDPHNQEANIHFSRIGPARDQWVLCVDLMERGDFNTAIALLTQLLEVCPWAVAIREARAQMYLRLGDRMAAVSDFRSVNRLSHDSTDGYYQLSRILYDIGDSGGALKEIRECLKLDPEHKDCFPFYKKIKKVDKVYVDAQTAREEQRYADCIASGEKLIKLEPDVPMIVYNGKQLLCSCLLKDEQFPSAVSRCREALDIYADPEVMCDRAEALVGAEMYDEAIAQYREALDINDNLQRAKDGIEHAQRVQKQAERRDYYKILGVKRSATKQEIVKAYRKAAQKWHPDNFQGDEKKMAEKKFIDVAAAKEVLTDPEKRRQFDAGQDPLDPEAGRNGFGGGNPFHHFQHGSPFQFKFHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTL0</accession>
    <name>A0A084VTL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004030-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008899</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTL0"/>
    <dbReference type="STRING" id="74873.A0A084VTL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008899-RA">
        <property type="protein sequence ID" value="ASIC008899-PA"/>
        <property type="gene ID" value="ASIC008899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008899"/>
    <dbReference type="OMA" id="QVTIICA"/>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008899-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="253" mass="28592" checksum="7C24432D22386FC9" modified="2014-10-29" version="1">MGDRNVELQTTLVRYNNPVLVVKHVEKREPAGDTANAPAKEQPGRPGSGGAVVVDSPRETEEILNCILPPKTWEEDGQLWTQTVSSTPATRQDVINLQEMLDTRLQQTQARETGICPVRRELYTQCFDELIRQVTINCTERGLLLLRVRDEIAMSLEAYETLYCSSVSFGIRKALQAQEGKEKLQEQIQLLEHEKEALLNSISDMKIKADQAERRNAELRASEEKKHSEEIAFLKKTNAQLKAQLEGIIAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTY7</accession>
    <name>A0A084VTY7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009016</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTY7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009016-RA">
        <property type="protein sequence ID" value="ASIC009016-PA"/>
        <property type="gene ID" value="ASIC009016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009016"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12208" checksum="0077397C606AF2F5" modified="2014-10-29" version="1">MENLFHQPTNSANHTLYSPFFAFASKAGLAKGTTVRRSLADGPNPSASFSSLVAWFRSERLGPGCSDRNETTFWLPRQFVGHGGPYLELIRPSRVWENGSSGSTNGGFGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUD3</accession>
    <name>A0A084VUD3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004851-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUD3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009179-RA">
        <property type="protein sequence ID" value="ASIC009179-PA"/>
        <property type="gene ID" value="ASIC009179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009179"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021494"/>
    <dbReference type="OMA" id="QHSNGWV"/>
    <dbReference type="OrthoDB" id="6597859at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="25250" checksum="79AD03D0FFE5AA2C" modified="2014-10-29" version="1">MICSSCNTVAVCLKIGSVWETVWVESCNPDEGLYCNEFEGGCSTSVGACNPGGGGTFECNTPGVFPDPHNCRLYHMCFMNGNNPVAISMDCGAGAFSPTTGDCSLLANDTICLSPQFTCTFAGQMAAWPGNSNIYYICAAETINGNRIFRPRLYRCPANQMFQDGQCVQRDWSNMPPGTIVPYECQRPGLFADPTNCRYYYSCNTDLVGERLQCPDGTYFESNLLTCVLGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUF8</accession>
    <name>A0A084VUF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009214</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525111">
        <property type="protein sequence ID" value="KFB41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009214-RA">
        <property type="protein sequence ID" value="ASIC009214-PA"/>
        <property type="gene ID" value="ASIC009214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009214"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9275" checksum="271200BA9A7A34FD" modified="2014-10-29" version="1">MEVNFPEYFSALKIRNEAEPSRAATHSSSAREEERTSHTSKKPTDVSRDGFKPVGRVPPGRRQQHHRLDKPCKRCELSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUJ6</accession>
    <name>A0A084VUJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009264</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB41640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009264-RA">
        <property type="protein sequence ID" value="ASIC009264-PA"/>
        <property type="gene ID" value="ASIC009264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009264"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6913" checksum="6B8F2208DEDE7BC9" modified="2014-10-29" version="1">MDDGFYATVSRMLMLFSKAPKPPYKRAWIAFAYYDSIFAVFEDHRRRTEMERAQWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUX8</accession>
    <name>A0A084VUX8_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009416</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009416-RA">
        <property type="protein sequence ID" value="ASIC009416-PA"/>
        <property type="gene ID" value="ASIC009416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009416"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="13883" checksum="78A8B799427EC4F8" modified="2014-10-29" version="1">MHGSLRAMQLLGGSARRCIPALIGQLAVVCRFSTCHGCNSTPTAGYLVRRSLSSLLSLLGVRLTSSKRTLEPVSGPSQPLATNCVNWQTARPKPNALETLVIAMTYLLAASYRPAVVLIEDLACELRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUZ6</accession>
    <name>A0A084VUZ6_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009434</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009434"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009434-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10695" checksum="53F78EA96E3F1A1B" modified="2014-10-29" version="1">MVRFEDAPAEDGRKRKEINKDGDINSITTRTHGNTDPLDGPKQSSSSLPTPDYRLPSADQPLAVAPGQRGAGINIRVVINWRGGLRDPCEEQRSREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVL6</accession>
    <name>A0A084VVL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nitrogenase molybdenum-iron protein, alpha and beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009588</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009588-RA">
        <property type="protein sequence ID" value="ASIC009588-PA"/>
        <property type="gene ID" value="ASIC009588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009588"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11675" checksum="1A0B045E1A331EEA" modified="2014-10-29" version="1">MGPATRHCFKHRRPRRTCLVRAFRGPSSSGRQLQLQLPITIATIISIILILSEVKRRAVLSSASDQATPQCSANQCLVNGAQQCASGFQWTCKRSSKLVHNSRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW07</accession>
    <name>A0A084VW07_ANOSI</name>
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        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009815</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW07"/>
    <dbReference type="STRING" id="74873.A0A084VW07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009815-RA">
        <property type="protein sequence ID" value="ASIC009815-PA"/>
        <property type="gene ID" value="ASIC009815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009815"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020662"/>
    <dbReference type="OMA" id="NDEHVEH"/>
    <dbReference type="OrthoDB" id="8187082at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009815-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="442" mass="49170" checksum="A6971D41584B5883" modified="2014-10-29" version="1">MPVAPCQRITTIQLDGVQYFISRMNPYSPELNYFLAYQYCRSLGLQLASFETKEKVESMTEYLQNAGYGKYNFWTSGNRLGTGMFLWMSTGLPFNATFDYFEKSPETVGMDPLDHNSNTSPQRTARDSSSGLQKGCVHLKAPSLRWAPEDCSAVKDFICEQTRCYYYNYGSIPVSSAQGRPIQTSTSTSLYTTLAATTTTTTTSTTTEAATTAAEARQFTSSTGSTTAPTLSSEPTSPLASLLNGDILEQDRTRRPIVQQQQHDNTAEEEHDEEQDQAEHDDDDEQLHDELEEDDEENVVGRSSGNASGIDAIEDEHEEHEHHDEEEDHEEQDETDDEEEQAADLHHQQALAAGQDTDAVSSGLPEDIPVEQKLKQITKEIEQLSGGAGADRELRVDSRQSFLSLSDLIKNIRPAEKVVPQIDSSYANTMRVLGEPLSHAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW40</accession>
    <name>A0A084VW40_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex I assembly factor TIMMDC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translocase of inner mitochondrial membrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525168">
        <property type="protein sequence ID" value="KFB42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW40"/>
    <dbReference type="STRING" id="74873.A0A084VW40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009853-RA">
        <property type="protein sequence ID" value="ASIC009853-PA"/>
        <property type="gene ID" value="ASIC009853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009853"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004354"/>
    <dbReference type="OMA" id="NSRVAYM"/>
    <dbReference type="OrthoDB" id="5826189at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055299">
        <property type="entry name" value="TIMMDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002">
        <property type="entry name" value="C3ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002:SF1">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="299" mass="33401" checksum="0A1835211AC17AD0" modified="2014-10-29" version="1">MLRRTVHKLCLPGGFVSAGLLPFTANDHDQIKIDTKTVQSMYEDAPGDKQTGMERLNMMFKIDEFGRVSSELNSIYQAGFLGFLFGACYGGFVNSRVAYMNFMERNQATAFQSSFEAKKKLQDQVTVNFAKGAFRWGWRLALFTTSYVGIQTVISVYRGKSSLYEYLAAGGVTGAMYKFSMGLRGMASGGLVGLALGGVAGGLSLGIMRATGTTMEEVRFWQYKWQTNRDQVIRESMKTQSDAEEEPLLTHHHNKFGTANIDLEAIEAEKRKIQLAVERETLMSKLDQEEPAPKQIEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWD0</accession>
    <name>A0A084VWD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009955</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWD0"/>
    <dbReference type="STRING" id="74873.A0A084VWD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009955-RA">
        <property type="protein sequence ID" value="ASIC009955-PA"/>
        <property type="gene ID" value="ASIC009955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009955"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007363"/>
    <dbReference type="OMA" id="YPMHQSV"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="150"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="435" mass="49750" checksum="DFCEFDECD6AEEA83" modified="2014-10-29" version="1">MSDSYPLHECVFNGDTRKLSSLLRTHEIAEKDKHGNTPLHLAVMLGRKECTFLLLAHGAPVKVKNSQGWSPLAEAISYGDRQIISSLLRKLKEQAREQMEQRRPNLVKALNQMGDFYMELKWDFHSWVPLISRILPSDVCKIHKSGCSIRLDTTLVDFSDMRWERGDISFIFKGENSPKDSLTALDNECRCYQHVRHEETELEIEDEVDILMSSDILAAQMSTKGISFTKAQSGWIFREDRRETVAGQYDSDLYTINGLTLEQRKRREHLSRDDLQKNKALMESLTKGGQAGQPGTIDQNGEIFRRASLQPPPTSGVRWEDYIAAEPGQYPNLGRELVYKESSKNFKATVAMSKDFPLSVDMLLNVLEVIAPFKHFSKLREFVTLKLPSGFPVKIDIPILPTVSAKITFQKFEFRDDISPDLFVIPDDYKEDTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXA8</accession>
    <name>A0A084VXA8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Dper\GL23756-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00010313</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525196">
        <property type="protein sequence ID" value="KFB42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VXA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010313-RA">
        <property type="protein sequence ID" value="ASIC010313-PA"/>
        <property type="gene ID" value="ASIC010313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010313"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019118"/>
    <dbReference type="OMA" id="XXKEITA"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010313-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="377" mass="41784" checksum="278FF4EF92257B42" modified="2014-10-29" version="1">MYDEDAGALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANRERMAQIMPCCPCTLPVVPPVLCRIPETVSPTPSQSLKDMLCLMPSXXXXXXXALPHAILRLDMAGRDLTDYLMKILTERGYAFTTTAEREIVRDIKEKLCYVALDFDQEMGTAATSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMETAGVHETVYSAIMRCDVDIRKDLYANTVLSGGTTMYPGXXXXXXXXKEITALAPSAIKIKIIAPPERKYSVWIGGSILASLSTFQSMWISKQEYDEAGPTVVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY30</accession>
    <name>A0A084VY30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010628</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010628-RA">
        <property type="protein sequence ID" value="ASIC010628-PA"/>
        <property type="gene ID" value="ASIC010628"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010628"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007459"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010628-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="19223" checksum="FFC516567CDB4E40" modified="2014-10-29" version="1">MASTARRVVLLPGGTGIGFGGRITILQAHRRHYHLPIRFTWFFHLASLVSGVVRSFPGTSGVRFVRLSPTQKEATEIGDRTPKRTFYFHSNGRSCSCFGESRNSTVIATGWRTRRLPSRSRCWFPQAATMTMAMATTSLFGQIERSTPSHRQQFDRSGVLLAFLTTFNRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ85</accession>
    <name>A0A084VZ85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP005527-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011063</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VZ85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011063-RA">
        <property type="protein sequence ID" value="ASIC011063-PA"/>
        <property type="gene ID" value="ASIC011063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011063"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010383"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020557"/>
    <dbReference type="OMA" id="TIDLLMC"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000191">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000324">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="912"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="651"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="658"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1364"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1459"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1484"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1502" mass="165576" checksum="68E978CD15A73331" modified="2014-10-29" version="1">MAEAQRMKMLNGHFVWLWMDTTSATEFYEAGQASYSPKQQMETSGGMGGRSELENDFYDTFDLRHHSHLADLVERRMEFEDFDPRRKNRTRTFVEGYSARYGSAALVNPQPEGPDPVGSLGAPGNSKQGKSRRPEKVKSGRVEKDGHGNHSLVDVLRRADRFDSEDSEEFDDFDDEGRVLPLVVGDDELELPGADSIAGQEMKLKRSSEYQLKPHNSSGHVLFHHNQDFPVGLLALRPIKMKIDRHFIRAAVRLFAATWAKVERDDTPATGKGRTWQSSGSISSTRSTAQDLPKGQRGQRPGQAPRKRSVVDNILTLPVNSANTQQSVHETSFLRHEPQSTIVDGAGTSVPPHAEQQQHPGSVAIDTGAATETMHVTNDIISPISNSSANFSDVGSTNSSRVKRQSTWWSAATNHKYNTDRGGPAGSGDRGRGRGGGGGATRYKGGCMGSINRAEQTKAYNFARNLQTNARQALSGFPIASGYIEKSLVSHFEILNLVPTTRQSSTKPDQHGDNSSHGGKYYGTSANGTASGSGTGGTGAEKGNLGIATKWRRVGLITGRSVHLDTIIWPGGDVTVSGLAGKAKTMFRVVVSVAPPFVMESPVNEEGECLRGLICYQIYTTGRHNLTLMFNEIERRNRLREIDPAPHLYNEDRHQAYPLYRKRCCYGLSMDLLQKLAAEINFDFHLYIVHDGLFGRRIPGTTNEQQTTGPAPPVRRPTPPTNVESKSKFDAQSGRSLKRGSKLKQAQAAANASRDEISYYPFEFSTAPPVRTRQQWNGVIGDLMSGTADLSFAPLSVSKARSEVIDFTIPYFHGGVSLLAAPETATDIPLLAFLLPFSPELWIAIFTSLNVTAVAVAIYEWLSPFGLNPWGRQRSKNFSMSSALWVMWGLLCGHLVAFKAPKSWPNKFLINVWGGFSVIFIASYTANIAALIAGLLFHNEGKYYEMSMLTQRVGSPIATAAESYVQQNDKRLWEHMKKYQLQSIDEGIQRLKNGTIDLLMCDTPILDYYRGTDQSCSLQRIGDNYIEDSYAIGMSKGFPLKKTMSALISKYSHDGYLDILTAKWYGDLPCFRLDREMAQPKPLGVTAVAGVFLLLGVGMVLGVLILIIEHVFYKYTLPILRHQPKDTIWKSRNIMFFSQKLYRFINCVELVSPHHAAKELVHTIRQGQITSLFQKSVKRKEDEQRRRRKSKAQFFEMIQEIRRVQLDTDVDVDASLSATSESTSQALLPEAHPVGGGRLSVSASASRRASPGQRMRFGFGKRDANASASKSSSFASSLNVRRFSTDSIISERLGTIGRRLSRDAATSSPPDLSHHFETFGKGGGGLAKEASKFDTYSGKNNSKESIVAVFKCDTFNGKLSSAGQDTVDAGGSSNSATNVNKGAGRAMPEGEEKPVLPVKTKKRSRRSPLNLELYESSRRRLIPINERVAQGLAPPFLEADTGSALLRDKLHEELRLKYGQTRWKGSASGNGASEGVENGGVESIKSTENQPGSSKRRPNRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZC1</accession>
    <name>A0A084VZC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">LSM domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011113</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525247">
        <property type="protein sequence ID" value="KFB43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZC1"/>
    <dbReference type="STRING" id="74873.A0A084VZC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011113-RA">
        <property type="protein sequence ID" value="ASIC011113-PA"/>
        <property type="gene ID" value="ASIC011113"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011113"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015576"/>
    <dbReference type="OMA" id="GHHIHIV"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011113-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12960" checksum="D72818A03E0A88F9" modified="2014-10-29" version="1">MEEENVVPGDDRPSERREEERTDETPAEDPDKDNPKRKKLKSWLNNMFRIKMTDGRVLIGIFVCTDADANIVMQVTSECPEIGGEERFLGLVMIPGRYIVSIEDRNDAGKFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZF3</accession>
    <name>A0A084VZF3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011141</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018753">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZF3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011141-RA">
        <property type="protein sequence ID" value="ASIC011141-PA"/>
        <property type="gene ID" value="ASIC011141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011141"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013613"/>
    <dbReference type="OMA" id="GWSRYFN"/>
    <dbReference type="OrthoDB" id="9435504at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8230" checksum="4F5A836A2688C2DB" modified="2014-10-29" version="1">MGMSEPKLKTDKDGIPIDDPSIRGWSRYFNNCTIRGRANVAKATLALMAVGTVYYRYFRPKGSAISETDASVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZV3</accession>
    <name>A0A084VZV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP004726-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011302</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZV3"/>
    <dbReference type="STRING" id="74873.A0A084VZV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011302-RA">
        <property type="protein sequence ID" value="ASIC011302-PA"/>
        <property type="gene ID" value="ASIC011302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011302"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001091"/>
    <dbReference type="OMA" id="NEEPRGY"/>
    <dbReference type="OrthoDB" id="6343110at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784352" evidence="7">
        <location>
            <begin position="24"/>
            <end position="588"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
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        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <position position="314"/>
        </location>
        <ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="528"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
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        </ligand>
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        <location>
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            <end position="547"/>
        </location>
        <ligand>
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        </ligand>
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            <begin position="288"/>
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        </location>
    </feature>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="588" mass="65305" checksum="6C295AEBBB2ED163" modified="2014-10-29" version="1">MEHRIHLPTLLKVVALLLSEALGESTTSVTPPTVHHFLETTLTTARHQPTTTAKQQVHAMALPALSSIPPEQIGSYVGVQTSGTSGGLLPTFTTEAFFTTPSPQAVSPQYNTSYTSSPTVSTTQPTIRQEPIDSLPVDITLIEEKQLGPGGPNQVESASIQRALTWLRERRLPDFSWGNDTHMVILAKELSGAKDPSESDNPIQAVSDLENLLSIKQMDIEVLTMLDRHHATAKLLNTDHIAKYILAMGGLCKDARHFYGHDLVAALEHHEHDQGQEYEFALTALAICSSATHVRKRQIRRLLDIASGEVNDVDTIAMVLLALRCIVTDHRHRHLQHFVRRPARGLASLQGLQGSFGSLRSTALAMQALQDLEPDPAGKWNRTAASEWLLAKQRTDGSWTEEPLQDGQDPTIGIGLTADIVLALGWRGLGAVRALQCDHVMRESNEPSENGEPKLAAPVGLGISPVEETEPRNVSYTYTLWVGTNETEEYYLDLTSPKNTTFFRAMKQAAEIDTRFSFEAREWPNGHYVHTLAGMKEEPKSYHFWLLYRLPERPDTKNPPGNQLIAPLGVDELLVEDGEHYLYWYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E5</accession>
    <name>A0A084W0E5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">ZHAS_00011419</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011419-RA">
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        <property type="gene ID" value="ASIC011419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011419"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011419-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6482" checksum="2A69B821FC0448FB" modified="2014-10-29" version="1">MVISFNESESPPPPGAPASIGGRGPENQKHGPSPPPHPDLRKADWLLAQTSARHPTVVTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1M0</accession>
    <name>A0A084W1M0_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP013161-PA-like protein</fullName>
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        <submittedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC011948-PA"/>
        <property type="gene ID" value="ASIC011948"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS010506"/>
    <dbReference type="OMA" id="KPPYGRV"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="520" mass="56637" checksum="0F5133D630261EEB" modified="2014-10-29" version="1">MELLLKVVALILRVLNVLLGPILAWLGGEQPRTEPFPPIRDELLRVPATELAERIRRRTVSSVDVVRTYVLRIRAVNPLINAVVEERFEAAIGEAVAADERVAACLGDESQLAELARQAPLLGVPLTVKESCSLKGMSLGGGVVRRQNLTASEDGEAVGRLRAAGAIPLLVSNTPEFCMAFESYNYVTGRTLNPYDPQRSAAGSSGGEGALLGAGASLCGIGSDLGGSIRIPALFCGVFGHKPSPGIVPIKGHMPVCDDAHFDQFLSLGPMCRYAKDLPLLLEVMSGPNASKLRLADPVDVSKVKIYYPQRLNLTVNAVPIAPEIRESLRTAVKHFQDKGNYSEPLNFRYFCDSMQIASASLQTLKELPNVFESKNPSLLWELVKVVSRQSEHTFATIFMYFLSATKATVSTEQRMKYLKMGEELKQDFTNKLGTDGVFLMPSFPKPALRHYESFGHVTGFMYTMIFNALGLPATQVPLGFNRHGLPVGIQVVGGPNQDRLCLAVAQELEKAFGGWQAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1S9</accession>
    <name>A0A084W1S9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Chromatin modification-related protein YNG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012013</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC012013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012013"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12937" checksum="B4301057898BE697" modified="2014-10-29" version="1">MQWKEWKNVPPNENVAAIEGNPREGTVGNANIISDASSSRRPRWKCIFKESKAEILPKEPTNEKRINKERQKRTDSDAWGENLGFPNGSNAEAFSSQLERALEKMRLRKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W234</accession>
    <name>A0A084W234_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012162</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W234"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012162-RA">
        <property type="protein sequence ID" value="ASIC012162-PA"/>
        <property type="gene ID" value="ASIC012162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012162"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7247" checksum="AB6965E3966C9E2D" modified="2014-10-29" version="1">MDVHPEVAGHSQNNSSNDEEEPEETARMARNRHLSLGSERNMCVAILPRGRVLLRSRLYTVCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W240</accession>
    <name>A0A084W240_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB44284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W240"/>
    <dbReference type="STRING" id="74873.A0A084W240"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012152-RA">
        <property type="protein sequence ID" value="ASIC012152-PA"/>
        <property type="gene ID" value="ASIC012152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023703"/>
    <dbReference type="OMA" id="YGYEQPQ"/>
    <dbReference type="OrthoDB" id="6376010at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF16">
        <property type="entry name" value="LP07342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784085" description="DUF243 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="291" mass="32356" checksum="AC59C8E1CBD629B3" modified="2014-10-29" version="1">MKVFVVLSAVLACAAARPEAGFSSYSSAPSFTSVGDFGGPYSGSNSGGGGGYNYSPAQQVVQKHIYVHVPPPEKEEVYYPRVSPVAPAQKHYKIIFIKAPSPPAPKAPIIPVQPQNEEKTLVYVLHKKPEEPEDIVIPTPPPTKPSKPEVYFIKYKTQKEKQSQPKPEYGPPGQSGPTTYLQRTNGLHQDENTNERKSLAHDAEWTNEIKTIAVPGPEVVRSLDRSSAGEPSDRCVWLQVPTSGKDDHDWRLYIDHVKHNTLICNGFFDRTFSSLRTAAYFQRKGKRQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W370</accession>
    <name>A0A084W370_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP001619-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00012549</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525280">
        <property type="protein sequence ID" value="KFB44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W370"/>
    <dbReference type="STRING" id="74873.A0A084W370"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012549-RA">
        <property type="protein sequence ID" value="ASIC012549-PA"/>
        <property type="gene ID" value="ASIC012549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018066"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021273"/>
    <dbReference type="OMA" id="PKMGFSI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000081">
        <property type="entry name" value="Empty spiracles homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="312" mass="33859" checksum="E78AAB215030C39F" modified="2014-10-29" version="1">MPMATGPTIVMALPTQKPRIGFSIESIVGGGQNRRPPKAPSLRTIDLSSNSSRSPPAGETCLSPEPARNHRRSASPPTRGPIMVPGVPAGLVRPFPMGGSAAELAVQAAHNQHLLAAQFQAAAAHLAHVQAHGPGGFHGHPAHLHGHHPHHPANIPRDSYPLYPWLLSRHGRNVFPPRFPGNYLLPFRKPKRVRTAFSPSQLLKLEHAFENNHYVVGAERKTLAQALSLTETQVKVWFQNRRTKHKRMQQEEDAKSGGNGDGSGGGTRSPGSPGGTYEDDEEDELIDMEMDDECPSGGEDDDDRGEDDHNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3I0</accession>
    <name>A0A084W3I0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP002118-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00012679</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020030">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525292">
        <property type="protein sequence ID" value="KFB44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3I0"/>
    <dbReference type="STRING" id="74873.A0A084W3I0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012679-RA">
        <property type="protein sequence ID" value="ASIC012679-PA"/>
        <property type="gene ID" value="ASIC012679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012679"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004831"/>
    <dbReference type="OMA" id="WTQTQQQ"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012679-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="386" mass="44109" checksum="9C240E4176554F11" modified="2014-10-29" version="1">MSSFTCLNCGVRFATAEMQREHYKTHWHRYNLKRKLAELPPVTIEEFEKRVNQQKSEDAAAQEDQSVYCKACRKVFKSKNAHDNHLDSKKHQENLKRYIEQSASSLAASSKDAMETEVEVTVKSTRAATRAAAAAAEAEAAGDAEMEGDSDEWEDVEFDNPIENNDCIFCPQHSEDLIGNIKHMSLAHSFFIPDAEFCVDVEGLLTYLAEKVCRDYICLWCNERGRTFYSIDAVRKHMAEKGHCKMLHEGAALAEYVDFYDYSSSYPDHEDGMDVDAELETPTALDGDEYQLVLPSGNVIGHRSLLRYYKQRINPNRAVVVKKSTQKLHKVLAQYRSLGWTSTQQEAAARNARDMHVMKRQQAKLMQKIGVKANKLQHHYRPQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W611</accession>
    <name>A0A084W611_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020717">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W611"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013512-RA">
        <property type="protein sequence ID" value="ASIC013512-PA"/>
        <property type="gene ID" value="ASIC013512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013512"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013512-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="187" mass="20852" checksum="50DB868990450296" modified="2014-10-29" version="1">MVSRILVEVLNVFKPNEYLNAIVNFTRDASIQNGGTNSSPFHLHRSLPPWFGVVQRNGTKKSTEASCARTELENGTPTRNGRERETRTRVPGVQELSRKKASPRRSLWRRVRGVCLKPQPRRASCVVAGLQPTKMSSPSREDGALRTDDDDEDGCGVACACWNIMDRRTLPVRYGDKCPGRLSAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W640</accession>
    <name>A0A084W640_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP010194-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013544</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W640"/>
    <dbReference type="STRING" id="74873.A0A084W640"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013544-RA">
        <property type="protein sequence ID" value="ASIC013544-PA"/>
        <property type="gene ID" value="ASIC013544"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013544"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005633"/>
    <dbReference type="OMA" id="RKCPKGN"/>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="201"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013544-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="370" mass="44400" checksum="40E6A82A04B795F6" modified="2014-10-29" version="1">MSLVQGKIKRKEWRKLCKKRRRKVVRQKAAKERDRLEEELQKEKDADPEYQKLLVEMLHQEEVAAGREALERALRNAQWLEEEHKAQQRFEQLRQQIETKEREEREKRERIRREFEERERRTEEARAERHRQQEEMVRLVRERHTKLQQFSATGIDDYLTELQMVHSTRADAVDCKFFTKTGTCRHGLRCSGNHPTPGLSKIILISNFFNHPALERTVHQEYGHDGRLEFDEEDLSNSFTDFFRDIVDEFERFGKIHQILVCRNFGLHLRGNVYIEYENMRHAAAAYLRMNGRFYAKKQLHVEFRSPIVWPAAVCGLFELKRCQKGPGCNFLHIFKNPDQRYQYDHFQQSRSMRKEASIVPATPLVLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W698</accession>
    <name>A0A084W698_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013713</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W698"/>
    <dbReference type="STRING" id="74873.A0A084W698"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013713-RA">
        <property type="protein sequence ID" value="ASIC013713-PA"/>
        <property type="gene ID" value="ASIC013713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013713"/>
    <dbReference type="OMA" id="IQTQNIR"/>
    <dbReference type="OrthoDB" id="7727916at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013713-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="389" mass="45403" checksum="4F09C0393FB5801E" modified="2014-10-29" version="1">MNRMQNEVHSYYRTLLADTFGMVMKISQWVFTAPYPLHPYQQVTSASRQRFYVLRFLQKCFAVLIFGTITAMPVLMYFLHDKSVYMYSVPMSIKIMYYMQTALQVVGTWYVVYVYQFRTSIHRYYFGHLLHVLEQFGRRDIDVGLRRVKRAVRIVILLIPVQIGMVALLIILQTKSWRQFPKLVTLGGTLLGTTINLQYMTIMGTVAILLRQMNDTLESFLTPTSDVQKTMSIQLIQPTRLTVDDQLTIEKIRLLQLELMKVVAKTNASGFGTFLCIFIIATFMYINILLLQVYQGLKQNVITFDIFCIRLINCAFKLWGYVMIAYSNRLVQKQNLRVGTILHQLNKVDNQTTCFNIINRFITQTCLFYNVHEAHEMIPIDMSLIFKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6A2</accession>
    <name>A0A084W6A2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020765">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6A2"/>
    <dbReference type="STRING" id="74873.A0A084W6A2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013718-RA">
        <property type="protein sequence ID" value="ASIC013718-PA"/>
        <property type="gene ID" value="ASIC013718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013718"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015291"/>
    <dbReference type="OMA" id="ICNCNCT"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013718-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8146" checksum="F181DB1DEA337352" modified="2014-10-29" version="1">MPFFEVSCKQNINIEEAFLTLARKIREQREHRGENFDDGDRQKGLQDMIKNGPGSNGLGPFTLGSGGEGGRCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7F2</accession>
    <name>A0A084W7F2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010772-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014144</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7F2"/>
    <dbReference type="STRING" id="74873.A0A084W7F2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014144-RA">
        <property type="protein sequence ID" value="ASIC014144-PA"/>
        <property type="gene ID" value="ASIC014144"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014144"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014517"/>
    <dbReference type="OMA" id="SEPAINY"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014144-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="363" mass="42241" checksum="0597361E70252B40" modified="2014-10-29" version="1">MLLQEIYKEFKDSIASAEERRDASEAEQKSKKSVTDDVVPTPSDRSQASVHELNSSEEVNRHSGVETYQQGKTRDTSSVYKSCKEVPTNESGIYRIQFKPNETLEVYCEQSTFGGGWLVFTYRYGGELDFERSWDDFRNGFGNLNDEFWMGLEFLHQLTSARKYELLFEIDWDDGPELEYYHFDEFVLGSEDQQYILNFGKNNGTEGFAGSFSTLRQGTKFSTKDRDNDEESTVNCAEMAIGGWWYKQCLLRGSEKKKHAASFRLMVREQEGVVQEMKNTVRTKDSAKIWIDPMMREQHGDMVNKTNFQDLKEVVQMKDIVNLTDKTVREQYGGFESFQERKEVRMNYTVRTNMSVFIMIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8L9</accession>
    <name>A0A084W8L9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Phosphoenolpyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014599</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8L9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014599-RA">
        <property type="protein sequence ID" value="ASIC014599-PA"/>
        <property type="gene ID" value="ASIC014599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014599"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15447" checksum="910014B36E01C084" modified="2014-10-29" version="1">MVSTAALYQRSGEEGHERETGALHEAYKFDAVDAGVDKVANHFEGALSPGGGGVEVMLPLSWVANRTGRDRLMWCTHPSRVPVETGGDLGRARGDERCERTTGDNYTFVRYVTLRRHRSGGLLLVADACGNATELRSNWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8P9</accession>
    <name>A0A084W8P9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014632</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8P9"/>
    <dbReference type="STRING" id="74873.A0A084W8P9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014632-RA">
        <property type="protein sequence ID" value="ASIC014632-PA"/>
        <property type="gene ID" value="ASIC014632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005462"/>
    <dbReference type="OMA" id="RIKAYYA"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Beta-Casp" evidence="11">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="466" mass="53025" checksum="C2C0A7FD411E55AC" modified="2014-10-29" version="1">MVDSELEIKAYYAGHVLGAAMFWIRVGSQSVVYTGDYNMTPDRHLGAAWIDKCKPDLLITESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNLKYPVYFAVGLTEKANNYYKMFITWTNQKIRKTFVQRNMFDFKHIKPFDKGYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGHKILGGAKKVEFENRQVVDVKMSVEYMSFSAHADAKGIMQLIQFCEPRNVMLVHGEAVKMEFLKEKIREEFKIECYTPANGETCTISTPIKIPVETSLSILKDEVKKYNAQPPDPKRRRIIHGILVMKDNKISLMSIDEIFNEAGIDRHVIRFISKIKLDDPGPPMRTIEKLYNMLNERLSGWTVTMNDNNSINVESVNIKIETEDVPSTAAQHGQSSVVSAHKICNVSWVNQDEDLGSYILGLLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9K4</accession>
    <name>A0A084W9K4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014906</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9K4"/>
    <dbReference type="STRING" id="74873.A0A084W9K4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014906-RA">
        <property type="protein sequence ID" value="ASIC014906-PA"/>
        <property type="gene ID" value="ASIC014906"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014906"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010093"/>
    <dbReference type="OMA" id="AVHLTNQ"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07132">
        <property type="entry name" value="ALDH_F3AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014906-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="495" mass="55240" checksum="E9ACAAFD0094E8B1" modified="2014-10-29" version="1">MSYSDVVQQLRASFNSGKTRNVEFRIKQLQALQRCYEENTAEMANVLASDLRKHKQEAHLLEIEFIMNDLRNTLYNLRDWVKPEKPDKSLVNMMDGVYIYKDPFGVVLVIGAWNYPLQLTLVPVAAAIAAGNCVVIKPSEVAPASAKFIAETLPKYLDADCYRVVTGGPKETSELLKEKFDYVFYTGSGRVGKIVHQACSENLTPCTLELGGKSPCYLDGTANIAVATRRILWGKFINAGQTCIAPDYVLCSKQVQKQFLEEARKVLNEWYGTNPKDSPDLCRIINQNHFQRLTSLLKGANVAIGGETDLQDRYIAPTILIDVKSTDPVMQDEIFGPILPILNVDNAYDAIKFINSRSPPLVMYIFTLDTKIQELFVYGTRSGSMCLNDTIMQYAVESLPFGGVGPSGMGSYHGKYSFDTFVHKKSCLTKDFNPIGEKLAASRYPPYSESKLSFLSTLLKKRQGINTAFLPYLLMFGIGVASTLLVSSILKKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAF9</accession>
    <name>A0A084WAF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015226</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015226-RA">
        <property type="protein sequence ID" value="ASIC015226-PA"/>
        <property type="gene ID" value="ASIC015226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015226"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015226-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21963" checksum="96BDE0828DD2EE19" modified="2014-10-29" version="1">MGRYDRKQKLPLNDTLFHRLTDNSYLLPDSGRLGTIVAKAKDKKRAKVGLTKDKRESRQLRGSAIFRQTQHDPAAADAIRSSFYRSPAFVYTIISRSRKGDRGPKGRSKLTLNQWFNKYIGGQKEQTNSARDLAEKGRNATKMQLHRASGCRWNKILPNRKGRPNKRTAQIGRNWFWQVQCFASPAKRICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAK7</accession>
    <name>A0A084WAK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022202">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015275-RA">
        <property type="protein sequence ID" value="ASIC015275-PA"/>
        <property type="gene ID" value="ASIC015275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015275"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017565"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8142" checksum="AC8BF1E74DECCD87" modified="2014-10-29" version="1">MFYFHRDSPTQKRRKTPQTLPSSTNATNAFVNNSQRKDAGVVSVAEGNTNPTGACQSPCREIMTNELAAALLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBU3</accession>
    <name>A0A084WBU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cytoplasmic dynein 1 intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015733</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022456">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015733-RA">
        <property type="protein sequence ID" value="ASIC015733-PA"/>
        <property type="gene ID" value="ASIC015733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015733"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015733-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12248" checksum="F2966801B5C276C2" modified="2014-10-29" version="1">MFLSDSQRFNISCSQQDSPTGLLDGCGRSHPVRMGFCVSPRSTIATLRHAQSTILSSYKTRDTKRHWRVLGGADPSVLAGRGWFAVRFRASIYRMTVTTLATIGSKAALGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD02</accession>
    <name>A0A084WD02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022906">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD02"/>
    <dbReference type="STRING" id="74873.A0A084WD02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016070-RA">
        <property type="protein sequence ID" value="ASIC016070-PA"/>
        <property type="gene ID" value="ASIC016070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016070"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007903"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="840" mass="92174" checksum="7F05E3DDCF6CF667" modified="2014-10-29" version="1">MENTRDETTRSYAGSEESESAASSLRAKPRIVDRELELARKRLALERLVFEFDISQRELELEELAIAIDKGMVQREPAKFHTAPCDQQAEIAMAQGDPSSLYTAPGARPVVGHSSPALTTVGPSRRQSQEYARWRQFFEDFHYSRAGRSQPATSVRHDTMAVPAWKMVGCGSVYAKDADLRKDADSPRSSISLATTGCGTSPDNVRRMGWMGSNTPSATTNRGPSPEPVRSQAGSNEFIYPAALGQGASPDRTLVNPLQEETRLQTLTRYTTAGCHGEEMQPREPVVHFASTEHGRDEMAAFEEWCYAIDYKKRDTAMVDTSTTPAMAYSYLSPENTATEKGHASGTAQTALLGSTAPTTYASNTGHTAQATRTDIGHAETHSEHTSHGTSHSSHSSLHGTGITLQQPGSNPEMIVQLKVDLGELMECEEGTMRQQIPENDRNSPAALHSTQDLQGMESDISGSIDTVASIPLKGCGRSKDSDDDDDDRRKRTQIIAYQPSSVRSSNLADEANGEDLHGILPGLEVVAMSLPHDDGDSRSSRVGDSTIDVLVLPEQLTRQSPVPDGGGYRDRDGGGMRESDNNHIDSGGGFDCEQDVRSGGGDLSDRAHWRGSNRQPLQPQLSSSVYRVGCPAGDGFRSRQESDVARMPNQPRFPGVQAVEERAENSVMLVSAELGERYGAVMLKVVPDYCGAVLAALFIEQRHIESSTQNNSLAPESIDHRQRERDALRLQSWWHGGNHRKRFLALLLSELSGRTLMMAEHFLKATQLRTMKFVSFGYPRNVVAIALDIERSSGTVTEVLELFFVQVDFTAIVLLAYLTLRLAIVLFKAEKIWCKKCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WES6</accession>
    <name>A0A084WES6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit rpc9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00016723</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.</text>
    </comment>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WES6"/>
    <dbReference type="STRING" id="74873.A0A084WES6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016723-RA">
        <property type="protein sequence ID" value="ASIC016723-PA"/>
        <property type="gene ID" value="ASIC016723"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016723"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002312"/>
    <dbReference type="OMA" id="WGMHNLA"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="14">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB48720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016723-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14766" checksum="3BBE2B198C85BB44" modified="2014-10-29" version="1">MEIVNPNAAILTNFEVMTALKNMKNNKKKFGLRNLATITYETVQYLEDTPCKEQSAAGIVQFLQAMKEFNLTKNECLMMVNDPPLSPLHIQLMIEDSDERLTEEQVAKILELAAKLRTTDATTTAEEATADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF35</accession>
    <name>A0A084WF35_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017009</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023289">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF35"/>
    <dbReference type="STRING" id="74873.A0A084WF35"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017009-RA">
        <property type="protein sequence ID" value="ASIC017009-PA"/>
        <property type="gene ID" value="ASIC017009"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017009"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019781"/>
    <dbReference type="OMA" id="QSRNGRC"/>
    <dbReference type="OrthoDB" id="433414at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017009-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71828" checksum="1F443F4AF7662596" modified="2014-10-29" version="1">MASINKCTITTQSIRPEGTSLQLQSAVSAINQPTLGPRKMGPHFATINWRGRKALTILFAYDLYISEKQKVTKAYYRLDAWTAMRNRSQQETSGPSNHINRKIPYFPEADLCAERLTSTIEFVNTKTIKVNIDLAQEAVKLQALKAGKTLFVAPSQKSDYLYAKIKPCNVDEVPLAQQKRIVKMLAGEETYEELGIEHAEPLDMIVVGCVAVTESGQRIGKGNGYVDLEIGILVDLGVITDRTVIATTVADEQVYPPLPEDLFTPVDFHIDLIVTPTRTLRTVRPTPRAVGIQWPLLSSRRLEVVRVLKKLKERLEAQGKVIELKDEDTDIESYRKPRNQRGGGGNGVGGQRRQQNRRRRGGFGRGSGGAGAEGGEGGEQKGAGGGDKQQQRNGEGTGEDGGGRMRKKKRVGRMKYPSYTRPDDDASPDPNVRRVMRQPGQDDENKSHHNAGAPRRRRNQRGGGGGGDGGDRENQRGGGGEDGGRGERRRRPAQHHHLGGVRIRVSNMFSVRFKDFKDELRARDCYPSKISKGRYGKCLLIFSKRGEGGPEDEQQQAEGLLQKLADMRITVLPDKEGDEPRQVELKCELEPAKQSNRPGDEDGDHEEGSRQQQQQGGGDGGGNNSGGSPPAAPPQAPEGDSPLKEPAAGGDQVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFD0</accession>
    <name>A0A084WFD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016919</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016919-RA">
        <property type="protein sequence ID" value="ASIC016919-PA"/>
        <property type="gene ID" value="ASIC016919"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016919"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016919-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="8895" checksum="8E54032F39E604D2" modified="2014-10-29" version="1">MPAVVSDWAVAAVHGGGDHLPSPFLSPDVFVPAGPDEPPRRGEREGMESPVVVSTIRRATRRKPLSSEPEGDDDLYIENFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGQ2</accession>
    <name>A0A084WGQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP000520-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00017496</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023664">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017496-RA">
        <property type="protein sequence ID" value="ASIC017496-PA"/>
        <property type="gene ID" value="ASIC017496"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017496"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006376"/>
    <dbReference type="OMA" id="WTLQMLD"/>
    <dbReference type="OrthoDB" id="8196286at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF4">
        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785008" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="350"/>
            <end position="493"/>
        </location>
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            <begin position="63"/>
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        <location>
            <begin position="1018"/>
            <end position="1128"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="196"/>
            <end position="220"/>
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            <end position="265"/>
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            <begin position="1110"/>
            <end position="1121"/>
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        <source>
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            <dbReference type="SMART" id="SM00703"/>
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        <source>
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    <sequence length="1128" mass="127376" checksum="5E37F26CF150FC62" modified="2014-10-29" version="1">MAVIFRHWYAALLVCLLVGAALVSEVDAFRLKEDRPGLAIVKRNLSPRLKKGFDGESGLIGGRKRWSVREEDEEEEEDEAVDEDDDDEEEDEDDEEGERESEAIRKATQQRLQRARRSKIVSGKAKPSKAPSKPAQKSVTSEKGKSKKQSVASDDKKDETQQAIESWLAGLGNVFRTIANRDNEDEGFLGWLGKLTAKDEDKPTAKNDADDGDDEKEKENPLINLLTSWLHTLDTGTDGDSNEEIRIRPVGDRREDASDEVDAKTSKGSRKPKQESKLVQLLNESPIAALFSAEELPKEASIETGPKKAKKVPQGPSKVVKQRIAISPEDFEQLLLRVPSFVPDYSLVPNEECRRQGHIFERQLRGKRLWALQMMDASAKLTSGLLRGNANQLGDFDLCTGIATKIQVKQNEQVRMRGKYCLAHVDVVAEDEELRLPVHLLQGRGFIKSTLNDPDHFLPRFTTINWGICLPAACTFEDAANIVKHFVRPYNSTGIKLFLELEEGNCHVRQVRTWSRLLKDNWQLVAVLGFYTFVVVVTLVATMNDYGIFIKIEPPSKLGASESEATSPDQLPTNVFHQTLMAFSLKKTLHQLIGSDTAFSEDGQDPAPARKDIRCLHGLKAVASIALFLALRLVPLGFQPFTNRNEFTESFSAPWSITVRLLMLYADVFLVISGFLAAYHMVREYRERAKVAWFKRIVGRYLRLTFPLIPVLVFYAWIWEHLGSGPQWGDVVVKNANLCKHNYLSNLFFIQNWYPVEEACAPHTVQLAIEMQLSVLAPFLMIVLVKNPFYGTAAYVILNGISTAIRFSSTTEDRLTPYVFNGVRLTQLYRTINLSFAETLHRLTPYLAGFGLGYLLQETGRQRQERGVHYAGWIGAAISLLWCVYFPLDIVRKDFQYDPGNAAQFAALAPLSFALGVCWLIYFCVTVEDSLLNRFLSSRPMVFLGNLSYSLSLVQFLVFFYFAGSTRGSEVFSFTSYVNRAEVCMLFGASLLLTVLFDLPIQNVKRLLDREGVLERMETNEPAKAEEQSEVQEPSEESTEQDKGAEKEASGESNDFVSPFDDRDEEDDGIWIRKSKVNPPVEDPVEDFWAQRDEDTVKAAPEPTKPNVKRRPESNGREWTRSWDLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHD5</accession>
    <name>A0A084WHD5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017646</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023807">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB49629.1"/>
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        <property type="protein sequence ID" value="ASIC017646-PA"/>
        <property type="gene ID" value="ASIC017646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017646"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017646-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="198" mass="21318" checksum="92B42FD3F4266D91" modified="2014-10-29" version="1">MCSLGFAISSSYVEPYVDHKQESPYRSESVNAGPKTGLCLCPWAPSFGPRPRSAMRSFCSGHYAFMYTHYRPQTLYVCLLDRLLISPSTRPSIGQPSEGCHGTSVSSASLSTTRTSNWFLVCTSTGLGGLHSSRGSSLLDRNGTSAGTAHYDPGDGREIEEEIVPFPLGSEELLSLAKTNKFSRPEPDGVGVLSSSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHZ0</accession>
    <name>A0A084WHZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00017855</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB49834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHZ0"/>
    <dbReference type="STRING" id="74873.A0A084WHZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017855-RA">
        <property type="protein sequence ID" value="ASIC017855-PA"/>
        <property type="gene ID" value="ASIC017855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017855"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011009"/>
    <dbReference type="OMA" id="CPSIQMP"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15094">
        <property type="entry name" value="7tmA_AstC_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000231">
        <property type="entry name" value="Allatostatin C receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="176"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB49834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="536" mass="58322" checksum="CC0FF20C750AE475" modified="2014-10-29" version="1">MDWNGTALANGTVDLLVAAGSVALSTLSPLPAITTHAHHQDSNTMASPAGDITIATAAHFHGGIPFPSELLTFLRQTTTSSSAAFTAASASANFTTFLNNITLRALTASGGGGASGSGTSSAEFTANLSRRFPHHPFFSTFFNESALDICPSIQMPVGNVISMILYALVAIVGLFGNTLVIYVVLRFSKMQTVTNMYILNLAIADQCFLIGIPFLITTMHLGEWTFGNAMCKAYMVSTSITQFTSSIFLFIMSADRYIAVCHPISSPRFRTPLVSKVVSALAWTASALIMLPVMLYANTIQREKDKMSCNIMWPSETGANSGTTFTLYSLILGFAIPLTLILMFYYLVIRKLRTVGPKSKSKEKKRSHRKVTKLVLTVITVYVLCWLPYWISQVALINSPPDICKSRLEITVFVLVSWLGYSNSAMNPILYAFLSDNFKKSFLKACTCAKGKDVNAQLQIENSFFPRFVRNRGSERGNSTKVLHVTNVQSSSSVRPSNEQPIVPISSGRLLDANNATPPATGAPIFTRPPVLHTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJH9</accession>
    <name>A0A084WJH9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00018646</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJH9"/>
    <dbReference type="STRING" id="74873.A0A084WJH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018646-RA">
        <property type="protein sequence ID" value="ASIC018646-PA"/>
        <property type="gene ID" value="ASIC018646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018646"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005631"/>
    <dbReference type="OMA" id="TVHTPKY"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000060">
        <property type="entry name" value="ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="137"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB50373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018646-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="37496" checksum="88FD007944EB3E34" modified="2014-10-29" version="1">MDTKEVTFIIKWSGKEYPIEDLTEHDTVAVLKHEICKKTQVRPERQKLLNLKHKGKPVTDDIRLGALELKANFKVMMVGSLEADIIEASSRPTDIGRVVNDLDNEDEDNVPLENKEVYLAKINKRIKDYTIKELNPPREGKRLLVLDIDYTIFDHRSVAENGAELMRPYLHEFLTSAYEHYDIAIWSATSMRWIVEKMKLLGVTDESRDYKLVFMLDDAAMITVLCPLRGVIEVKPLGVIWGKYSQYSSKNTIMFDDLRRNFLMNPKSGLRIKPFSEAHVNRHKDKELPKLAKYLKAIAEHCDDFDTLNHKKWEEYLSKKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKE7</accession>
    <name>A0A084WKE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018730-RA">
        <property type="protein sequence ID" value="ASIC018730-PA"/>
        <property type="gene ID" value="ASIC018730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018730"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14650" checksum="D3C3A70109EBD912" modified="2014-10-29" version="1">MENCFVENWFSEPLHHVNQITYQPNYGAFPLHTISTLLGKPPPRRGAKKDTLSFCADSSGPPVLSLMTEIAGDFHGSHPEVAKDSKRLLTVGYFIVRTDPIWPVMSPNAIRRTERRENASGKWIPEYGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL34</accession>
    <name>A0A084WL34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018965</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018965-RA">
        <property type="protein sequence ID" value="ASIC018965-PA"/>
        <property type="gene ID" value="ASIC018965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018965"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14626" checksum="B9E3A22C6EC967F9" modified="2014-10-29" version="1">MADRKTTPNVTLMVIFDGRTKPGALCNTKGHNLRAIESVNQAKHNRAHQPPTNGSKRNHSSQLAINLKNLPRAPRAREELDTNSLFLAVLGVNLVSATETGRSKLFHWDLEAGTPPRCDHRVTATREQARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLJ5</accession>
    <name>A0A084WLJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006728-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLJ5"/>
    <dbReference type="STRING" id="74873.A0A084WLJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019146-RA">
        <property type="protein sequence ID" value="ASIC019146-PA"/>
        <property type="gene ID" value="ASIC019146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019146"/>
    <dbReference type="OMA" id="SAERDIC"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11618" checksum="003489E129AB205E" modified="2014-10-29" version="1">MDRVNINVKAGTVSGVIEKQPDGNDFCAFRGIPYAKAPVGSGRFQPPEPLDRFQTPVLDCSAERDICISKNPFNQKWNGSEDCLHLNVYTPQIRSQCSIRYAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLV5</accession>
    <name>A0A084WLV5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019462</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024294">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLV5"/>
    <dbReference type="STRING" id="74873.A0A084WLV5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019462-RA">
        <property type="protein sequence ID" value="ASIC019462-PA"/>
        <property type="gene ID" value="ASIC019462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019462"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020031"/>
    <dbReference type="OMA" id="RKAIVCF"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13364" checksum="24500335A72539DF" modified="2014-10-29" version="1">MDVNTALQEVLKKSLIADGLVHGIHEACKALDKRQAVLCILAESCDEPQYKKLITALCNEHQIPLIRVDSNKKLGEWSGLCKIDKEGKPRKICGASCVVLKDFGEETPALDVIKEHLRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMT2</accession>
    <name>A0A084WMT2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMT2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019588-RA">
        <property type="protein sequence ID" value="ASIC019588-PA"/>
        <property type="gene ID" value="ASIC019588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019588"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7494" checksum="046BA695BF02B8C6" modified="2014-10-29" version="1">MSKESSHLPLSALPALNDPNLDEVPNRLVQNSSTKHEGTSETSRQIQPNGMEVDRSLRNGRTLVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN76</accession>
    <name>A0A084WN76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007443-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00019753</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN76"/>
    <dbReference type="STRING" id="74873.A0A084WN76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019753-RA">
        <property type="protein sequence ID" value="ASIC019753-PA"/>
        <property type="gene ID" value="ASIC019753"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019753"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012123"/>
    <dbReference type="OMA" id="AERTITW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785173" evidence="3">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019753-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="435" mass="48501" checksum="78EEE7B9B3254ACE" modified="2014-10-29" version="1">MAAILITSWVVLPCSGQCTMGIANTCMLNSLNMASDGIATLRKIPPNVFYAISVELVRMPENPSGVFLQRMAEFVNKIEIYQYYEQVFQILPGTSLQAVTVYRALSLNQVVIAPNLNISELFITVCPLVRIPPTIRNLEQLKVLTITRCAVKEFSFDLFTNNLKLDTLDLSFNEIRSIVPTTISTPFTLPIENLYLQNNLLEKLDMTAFVSLGALRGLDLSYNNLLTIAAQSTVTWPAVDFWNLQNNNLTTLDLQWLSAPNLQRLLLDSNKFQAVPQRLRRFPSLQLVAMSDNLLKSIDLAPFNGLPNLNSIDFSYNKEARGIRATRPVSLPMLTTLYAEHCALVRFNTTGLDLPVINYISLSHNNFTTVPRLATAFPSIDSFSLEYNPLPCTTVQAMTENIMSGRLIVGLPQDPEDCTSGYVTLKGSLTLCCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WND4</accession>
    <name>A0A084WND4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019818</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WND4"/>
    <dbReference type="STRING" id="74873.A0A084WND4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019818-RA">
        <property type="protein sequence ID" value="ASIC019818-PA"/>
        <property type="gene ID" value="ASIC019818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019818"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007393"/>
    <dbReference type="OMA" id="RFACEYC"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="465" mass="54664" checksum="B5F89D42BC483BCC" modified="2014-10-29" version="1">MEFSVSTESCRVCLRKTPTGKFLLEPVKGKEHTEHRTLLSLYNLCTGFTDPPWTQEETNTFFPQKICSACEQLLLTTYEFRKLSKKSEKVLQHILLFYNDDESSCIVLEESNREDRLQEDQFEEDCVDESIEECEQQDVLVEAGTETVDDRGLELLQEAALLSLEKVAETSECISSQEECPEYCDQPNEYATNELFQNEDAVLEECKEQPDLDEFIDFESLVDEDEQEEADRGEVFYESRNPSLPHHVECPDCGKLISTPYLPKHRETHQATQRFECDVCKMRFTFLENLTKHKRIHDNDKRYECPYCQELFLHWTSRRYHIERVHTKEKRFACEYCGAKFRQSSHYQIHLRRHTGSTPYPCSLCDKSFVTSSSRKEHMRSHSDEKEFQCKHCRKRYKSVKSLKVHMKTHSNLKEYVCSECEKSFTQNHSLRTHQMNEHPGLILPPPGTVMNIRAINRLQNDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNE0</accession>
    <name>A0A084WNE0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019825</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Rough endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01024592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WNE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019825-RA">
        <property type="protein sequence ID" value="ASIC019825-PA"/>
        <property type="gene ID" value="ASIC019825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019825"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020576"/>
    <dbReference type="OMA" id="SMGIMLP"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="922"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="959"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019825-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1371" mass="149040" checksum="9D6024A389568577" modified="2014-10-29" version="1">MGILLPPVSQVTNTRINMTQHHRNRSLDSALQRIPEVEVSSPSAESENTLHCPNAILSGTMCSKIIQTSSTNPTNTPSNSGGRGSSASAVGPTPTGTLGTVHGANVGTQGVEMRKQTAGKGDKLDRGSATLRTLKGSHSTDAETISGSKDSESKKREDLTSLGSDDSGIICGSEPDHTSLTRIRRSRESLDSGEIDPSEEECIEILETTSMEEEYRMLQSDLCFYPVVERQKDDGAQTDDACIEPQQTTVTAAGSTHQPPLTDKVRYRQQNMTRAAIMLEKLFVPIDYEDGIAGAAVGNEEDEMLLPDAPTPIVGEGKSLTTPTNALTPVLPGGAAVPPATAATIVPSTNTDKAGASSESQPPPAPPTKADQKNEVIFRNFFGATKNAIFRTAQSIIDNHEKKHAAKNRDKGQPSEEGTAANSSVGSSGTTGGSAGGNSAVATVKSPTELSRKREFGSMFGSRSKQQQTSSVTSPTVSEPSEASTGETPAAGNHLLVVAPKTASLSKSSSTASLKVVPGVAVAASSCLPPVEHSVNGNVTRDESGQIRTDRSGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDAEVDLYIPQLIVMYMQIEELSEVLDPYLVYRCRQSVDFSLKCVWLLEAYNFNMEMLSAAGNSIRKHLSLLRELYPKRERVKTACPNKVSPSGGDSAGAGAQHNDLAPGSGQHPALSAVRKTHHRSQSDATGMLGMLSVNPKMLLYGQPSAGTGLPTQQHLLHPLPALPPTGSSSSRTACLGDLSTGRAFDNGCPCFESVRGTVNDLLGQQTVCSCGAPKLAPEKEFMKALIDIGKMLTCLQTKIEKTSRLRILLNLINKNLPARVWLPLHSETPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEVHDIYTSPVIPKLMPTLRHTKSEERLDSGLNGEPSPAAAVHQTKTDMPTQASPQPGEDASSLPSAALTATSTRTAGGRHSKLSECSVENGTGAGTGGSMMELGLTEDDVWSQEDDEITAQYLSLTKMSTDRDTISQFSVDSYDSREHHTPALFNIGEVKKRHCANLNSENAKPFSNDPSDPSAAALKEPWHEKEKQIRESSPYGHLQNWKLLSAIVKCGDDLRQELMATQLLQMFKLIWDEEKVGLWVRPYRIVCLSNDSGLIETIVNTVSLHQIKKNSNKSLKDYFVDEYGTPETDLFRRAQRNFMQSCAAYCLISYLLQVKDRHNGNILLHSDGHLIHIDFGFILSISPKNLGFEQSPFKLTPEFVDVMGGPESELYCEFKYLLLDGLKAARKHMDRIINIVEIMRSSSQLPCFKNGCSGTVRNLRNRFHMNLTEQELERKVEQLIQDSLNSLSTKLYDGYQYITNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNI9</accession>
    <name>A0A084WNI9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00019935</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNI9"/>
    <dbReference type="STRING" id="74873.A0A084WNI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019935-RA">
        <property type="protein sequence ID" value="ASIC019935-PA"/>
        <property type="gene ID" value="ASIC019935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019935"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015260"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="417" mass="48111" checksum="B8D05330FEB96278" modified="2014-10-29" version="1">MIYSQETVDDVRVIVKHAKLDHKNLTNTAQAIYYPKEEPGHDLGNIKLLEVDEHILQAVENNDEVCFKGALNEKVVFCTESRTYEVKEAEISNSLLLVNGLKLAQATSRSPIKSPKGGVNTSMDSSMEEEDEPAVIDTIDDVERKEVVKVFHDYFELRQVKPKYRKIIDLLRLTRYAGPENEHLIDRSLLFRFGQLLDTVQCSKEEFHEGLKKYRAIEVEDRIRMLDIEYEYRVLTLLLGVILENSWELDAIDKDTTLEAMQGIIPYEIVNGTFDVYTIPSERMPGRWQYREDMVCALFAEKILQNGLKFHIDEFLVTWQEALPEGFEVSEKYLRGIGIVDREGNVPCVRGLNEADLPMNLLVRLNTLFHTKERWNLEQIEPYIECFATPTVGVTSILAKYTRSLVVKGVRMYVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNY9</accession>
    <name>A0A084WNY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004013-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020097</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020097-RA">
        <property type="protein sequence ID" value="ASIC020097-PA"/>
        <property type="gene ID" value="ASIC020097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020097"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008574"/>
    <dbReference type="OMA" id="ESHCANW"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785268" evidence="6">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020097-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="499" mass="55995" checksum="FB0EAFCB79E9470D" modified="2014-10-29" version="1">MKLSGLLVLIASCCSLAAIVPRKVAKPFLLDKLRRTSLAGVANPHSTANITEEFFTTAVDHFNHQNQATWNNRYLSMMDHFVPTGPVLIFLAGDVPVAGSMIDESTLINEMARDLGGAVFALETRFYGQSLPTDDLSVDNLRLLNTDQILADVADFVVHLRRTVIGNPFAHVLVVGTGLGGGLATWFRVRYPHLTDAAWSSSGYVNAVYDFQDFSSSWANTAIEFGSQECYNRIFIAFHVAQNLIDAGLARLMYEKFNICDPIDGDDRIHVAYFFSVLMTSIEVYTIRRGNLADFTSVCQEITDDTFPTSLDAFAYWFNKRFDEDIGCVIVDLDTVAESFRDASPADEINASGARQFLYQQCTEFGWFFTTDSDLQPFGERIQMELYYELCRRVFGDWVTPEVMYWATDRTNSRFGGSSPNVMQVHFTNGAQDPWRYTSVVEDLNVYAQADVIPRELAGSDLGAISEENDSAELLDVKRRLKEVLAGYLFPFNPRKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPB6</accession>
    <name>A0A084WPB6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin polyglutamylase ttll-15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020246</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525367">
        <property type="protein sequence ID" value="KFB52060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPB6"/>
    <dbReference type="STRING" id="74873.A0A084WPB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020246-RA">
        <property type="protein sequence ID" value="ASIC020246-PA"/>
        <property type="gene ID" value="ASIC020246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020246"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021653"/>
    <dbReference type="OMA" id="CGYITNK"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020246-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62727" checksum="64F634EE1F2F6A2B" modified="2014-10-29" version="1">MPDKRKEDNNKKPDERARSGEKVRPVSTVDKQPRHTDDSGSFFDLRTKSGQILFMAVTITAVTLVQCLPKESLKSLLRLEYPTQPCKPDVQFVEKKVFSTEPRPTYWIYGRNPTGGHLLHVHNVLQRLGIEQTTNDTNEWDLLWAHDYPFRQINLQRMKPHQLVNHFPGSGYITNKVDLSTTRLPYIPAAFKLPAEASLFREYATANPGKKFVQKNNQHRHIQIKGMEEIDFNSNDTFIQEFIDDPFLVDGYKFDIGVYTVITSIDPLRVYIYKGDILFRYCPVPYYPFNASNVDKYIVGDDYLPTWEVPSLKQYYEKFGFGMKDSFDAYVRSTGQDPDVIWQQVEDAIRTLILKKEPLLAALLPRYANRKNFFEMMRFDLVVDKHLKVFLMEANMSPNLSSAHFKPNRLLYEQVIYNLFQLVGVGSSIRRDSFRKRATEAEAMVSSVKNIAVSANQCSELPCMESCAPVECQLCTTCLEENRVADLHRAYREHLNRGDMKRIFPVPKADQHKVDYDILTASNQLMSKWFEEKCKVDHSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPS2</accession>
    <name>A0A084WPS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP000063-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00020326</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPS2"/>
    <dbReference type="STRING" id="74873.A0A084WPS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020326-RA">
        <property type="protein sequence ID" value="ASIC020326-PA"/>
        <property type="gene ID" value="ASIC020326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020326"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012967"/>
    <dbReference type="OMA" id="HFAYSAA"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="35"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="584" mass="61815" checksum="60D565CEA10D144A" modified="2014-10-29" version="1">MALKLKQRKFQTPSLHLLQLRSGVENAPASATGCSHSGVNQLGGIFVGGRPLPDSTRQRIVELAHAGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVNKISQFKNNCPNIFAWEIRDKLLNERICTPENIPSVSSINRVLRNLAAQKEFSKKPHAQDTLSDDVVGSYLPGKSLNESSFIHYKYGDGCRASMQQGAESVLRLNDNYRAGNAAAVAAEPDVKPLGGDEPAVKHQFGGKQHCFASLDPAASVPKQPPGFVDSDTERLSLKRKLQRNRTSFTVDQIEFLEKEFERTHYPDVFSRERLSSKTNLPEARIQVWFSNRRAKWRREEKQRSQAVSEGSSSAASAAAAAAAAAAAAAAAAAAVQNASISSCSLNLSTGPLVTHVYDSNMCVEDSNSNYLSKTYPLEPSFQNLDALKSPPGTGSHPAAPQAQLSPASMSFKMSFPNAGQSSGGGGGPNGGSAGGGGGGSGGGSGGGVPDASSASLMGGVALGNNSSFSHVSTSDDKSLYNHFAYSAAANMHHSYSAAAAAAVDQSYNGMYLKNQLYNIPTNAGVLSFQSTLEWNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRB3</accession>
    <name>A0A084WRB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021067</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026009">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021067-RA">
        <property type="protein sequence ID" value="ASIC021067-PA"/>
        <property type="gene ID" value="ASIC021067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021067"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021067-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17357" checksum="9DF84A99AD69C045" modified="2014-10-29" version="1">MFGRAVVWKGRTQAHGSGNGNIKQQRQRRQRQPGFHSPVKTEERKWENDRPIGRWVEGGFWDCGREAACLGIGVIVRTWCARAAGVLVAKKKHKGFRTTDGGDAGKWPWGGRAGGGITMNGTASSRWSSRGFRMSPVRNGKTRCLLRYEAKDASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRI5</accession>
    <name>A0A084WRI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002575-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00021098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525406">
        <property type="protein sequence ID" value="KFB52829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRI5"/>
    <dbReference type="STRING" id="74873.A0A084WRI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021098-RA">
        <property type="protein sequence ID" value="ASIC021098-PA"/>
        <property type="gene ID" value="ASIC021098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021098"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022530"/>
    <dbReference type="OMA" id="WINVKSN"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB52829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="254" mass="28364" checksum="064F27955DDBA7CF" modified="2014-10-29" version="1">MRPPTHFGNDITNTEANGTEEQNNQTNNNGGSGGNNGNGGNNNNNNSNNNGRSNTDFIVERLTQNGATRPLPKNAGSGIIRVVERCDDAKENSNLDLSECELIQVPDAVYHLMRNTELKTCDLSGNVITKISPKFAVKFSFITELNLSHNQMARLPDELADLHSLEVLDISHNSFISLPTVVFKMPKLRELRANNNAIIDIDRDEIITSESLELVDLRHNPLTPFCHDLLMRANVSFRIELSDRVKEDWEDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRV8</accession>
    <name>A0A084WRV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021231</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026229">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525408">
        <property type="protein sequence ID" value="KFB52952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021231-RA">
        <property type="protein sequence ID" value="ASIC021231-PA"/>
        <property type="gene ID" value="ASIC021231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021231"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021231-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10519" checksum="FF5B9B8985145B47" modified="2014-10-29" version="1">MKRKVGGGKGGLRVRGESKSPSLNGHDNGGDYSLSHASAATIRYNYKRQKHTHTPAHTSKRLLQPFHHFGAILMDVSFASRSTPPAPDDPWESARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT17</accession>
    <name>A0A084WT17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013095-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021672</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026803">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT17"/>
    <dbReference type="STRING" id="74873.A0A084WT17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021672-RA">
        <property type="protein sequence ID" value="ASIC021672-PA"/>
        <property type="gene ID" value="ASIC021672"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021672"/>
    <dbReference type="OMA" id="HYIREVE"/>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021672-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="11055" checksum="14C07FE245F4BC3E" modified="2014-10-29" version="1">MSAMHYIREVESATTFIRDRMTIACLPFRRRATLRAPIELTKRLEEVRLLESRRSLRLAVQEKDTDFARLADMAGDRRRQSSSIDVPFSLTQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT58</accession>
    <name>A0A084WT58_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00021948</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01026856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT58"/>
    <dbReference type="STRING" id="74873.A0A084WT58"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021948-RA">
        <property type="protein sequence ID" value="ASIC021948-PA"/>
        <property type="gene ID" value="ASIC021948"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021948"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010250"/>
    <dbReference type="OMA" id="FPRIWHW"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF116">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="245" mass="28205" checksum="03C1DC2E961FFEE4" modified="2014-10-29" version="1">MLSAVPALFEYSQNWFNKNRDVRSMHLPLADSPGAVLGIIAVYLYFVLIYGPRLMNKRKAYNLLSVIQAYNMLQIIANGAVFIKICYNVFIVCDRFSFRCQPIDFSTSNAGWDEVYISYAYFLLKLLDLIDTVFFVLRKKQSHVSFLHVYHHSVMVATAYCGLVFVPGGHALMLGLWNTLVHTVMYFYYFLASLGSANIWWKNYLTRLQLVQFVYLAIHFGQPLVDVLSQYLLSKWLMSVPKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTA6</accession>
    <name>A0A084WTA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Hsp33 chaperonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021955</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021955-RA">
        <property type="protein sequence ID" value="ASIC021955-PA"/>
        <property type="gene ID" value="ASIC021955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021955"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5912" checksum="1B9FDB65EB02343E" modified="2014-10-29" version="1">MKATSGQRLYDIRSKNGWPWEGVVPSQGTDKDEKKVYEITSDKKCQPAVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTN7</accession>
    <name>A0A084WTN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002614-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">DRY_EERY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00021817</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUH3</accession>
    <name>A0A084WUH3_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00022310</name>
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    <organism evidence="1">
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="EMBL" id="KFB53867.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11588" checksum="B83EC7B762AE2EFB" modified="2014-10-29" version="1">MVPIVACLPGITPAAATTSYRNVAGWAENHHTTVRRRQRPEAATGRWPKEGSLVEVYQYGASAETIINHTQHIGAAWHQLARAYIHIVGSAPPPAKKKGPSVDGTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9W7</accession>
    <name>A0A084V9W7_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Toxin HicA</fullName>
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        <name evidence="2" type="ORF">ZHAS_00000150</name>
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    <organism evidence="2">
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            <taxon>Culicoidea</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS006542"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34761.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000150-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11305" checksum="A5988056B92EA880" modified="2014-10-29" version="1">MSIFPASSSMQVHRGGKSRRKFASSEKLYPTCGMGSLQPSSTSLFDKSVINSLRAWYHLSFGADDTGCRHSITYFSLRLSARPFVPTFSLDAFFLPRSAPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAN2</accession>
    <name>A0A084VAN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP002492-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00000844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAN2"/>
    <dbReference type="STRING" id="74873.A0A084VAN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000844-RA">
        <property type="protein sequence ID" value="ASIC000844-PA"/>
        <property type="gene ID" value="ASIC000844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000844"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011992"/>
    <dbReference type="OMA" id="MLMQGSN"/>
    <dbReference type="OrthoDB" id="10031051at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7152" checksum="80DCA885B1103C43" modified="2014-10-29" version="1">MCDLVENGDGTMETITVGPGMHQMMIQGPPGSEPQVLQVLSLKDASVLTKAMAAISDVKGEEATIIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAR4</accession>
    <name>A0A084VAR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000879</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004137">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000879-RA">
        <property type="protein sequence ID" value="ASIC000879-PA"/>
        <property type="gene ID" value="ASIC000879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000879"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8766" checksum="A7338B5EBEF82988" modified="2014-10-29" version="1">MGVVSDFSKHSGTEWYEQFSTGGLGNCHSIFTRKSTIANVEYTDRSTEETPPGYSSHGEICKVRNPTVRVHPNAGTRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCN8</accession>
    <name>A0A084VCN8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002632</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes juvenile hormone hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01010838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524620">
        <property type="protein sequence ID" value="KFB35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCN8"/>
    <dbReference type="STRING" id="74873.A0A084VCN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002632-RA">
        <property type="protein sequence ID" value="ASIC002632-PA"/>
        <property type="gene ID" value="ASIC002632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022232"/>
    <dbReference type="OMA" id="WVKQKYH"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759801" description="Epoxide hydrolase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="9">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="461" mass="52652" checksum="24C68C64622F8EDD" modified="2014-10-29" version="1">MGFCGRALVVVVTLLTAIVYKQYREMSAPMPVPELNLKRYWGPGDEKQYKEDVSIKPFKIDYGPEVIDKLRTKLNDVPALTPPLDGTAFEYGFNTDRLKDVLAYWRTSYLDKWSNGRQKFLNKFPHFQTQIQGLNMHFIHVKPDNVPKGTKVLPLLLLHGWPGSVREFYDVIPKLTTKSDDKPGYVFEVIVPSLPGYGWSQGSSKKGLSPSEVAIVMKNLMTRIGFKKFYIQGGDWGSLIGNYMATFFQQDVLGLHLNMCSIMTPLSYPKMFLAALKPSLFIDEQYVDYYFPLGSKFSNMIEETGYMHIQATKPDTIGTVLQGNPIGIAAYILEKFSTWTNPAYRNLPDGGLEKYFTLDALLDNVMIYYLTDSITTSQRIYAEAFAADELKKEFDRIPTTVPAACAKFRHELFQQIDWVLRDHFTNLVQSNHFDDGGHFAAMQLPDVLYKDFVQFINTVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDJ3</accession>
    <name>A0A084VDJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003058</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524690">
        <property type="protein sequence ID" value="KFB36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003058-RA">
        <property type="protein sequence ID" value="ASIC003058-PA"/>
        <property type="gene ID" value="ASIC003058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003058"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003058-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5916" checksum="F29D2A11030757D4" modified="2014-10-29" version="1">MNGESFISSRWATGAKPHRVHALITLGIMSYQQHTRHTLENTAAKEKYIHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDW9</accession>
    <name>A0A084VDW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003042-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003225</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524725">
        <property type="protein sequence ID" value="KFB36163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDW9"/>
    <dbReference type="STRING" id="74873.A0A084VDW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003225-RA">
        <property type="protein sequence ID" value="ASIC003225-PA"/>
        <property type="gene ID" value="ASIC003225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003225"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005982"/>
    <dbReference type="OMA" id="CQVRCVQ"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003225-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="415" mass="46209" checksum="273D8DA8BDA18F76" modified="2014-10-29" version="1">MCGEVVECLIDFIHPSLPEHKISQSNSDILENLAWATVQLHCYCNASMNDRTGNDVAASRNVGGTTSLNASNQLKGEVLQSTEPKILFCDLRLSPGEAKQFLYRETVPLNTPPTYRGIRVKYYYKITIATQRLGSSVQALNIPIRVLPLPLPQSDLDEAITLNDESNEDLAPNNPFLEKRRPPSRIEYALHYLRGVTARRRPNFFMITNKWGKVGRFCLFKSAYKLGEDIVATIDFSCGTVKCVQLSVTLQCEEIELKAPPAGAVVPKVGDETVATDAGAPEPNSTQPNGVGSGELDRKKCISRVTNYSKHHEVCLGMLQTQVILPIPLHVTPTFRTDLVEVSWRLHFQFVTSTNPELSSESLIDRSAENEDELEWVAPTDIAIETMIWSLPITIYPTAPLQIPQPCGEYKLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF10</accession>
    <name>A0A084VF10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC100877370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003743</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003743-RA">
        <property type="protein sequence ID" value="ASIC003743-PA"/>
        <property type="gene ID" value="ASIC003743"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003743"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017259"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003743-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13361" checksum="6E66CE7C5D151B94" modified="2014-10-29" version="1">MNYVKDQQNVAQQADPDDAADPVDEQNAHHPHTQCKGGEAVFENDSVPTFLIEKVISSNTENNEQQTVNGTGCAQNNACLGNLCDREEISYATENPTVNVELAPEIEDEYENETFENDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF67</accession>
    <name>A0A084VF67_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00003810</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF67"/>
    <dbReference type="STRING" id="74873.A0A084VF67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003810-RA">
        <property type="protein sequence ID" value="ASIC003810-PA"/>
        <property type="gene ID" value="ASIC003810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003810"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012836"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003810-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="24523" checksum="94AB85B6CC17F297" modified="2014-10-29" version="1">MAEGDMPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLVFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALLPPEVKMDKDWQVQIEKDLEEAQHTALPDEDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFA5</accession>
    <name>A0A084VFA5_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP007647-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012371">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFA5"/>
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        <property type="protein sequence ID" value="ASIC003706-PA"/>
        <property type="gene ID" value="ASIC003706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003706"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001645"/>
    <dbReference type="OMA" id="MVICTRP"/>
    <dbReference type="OrthoDB" id="7398970at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032150">
        <property type="entry name" value="DUF4820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16091">
        <property type="entry name" value="DUF4820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
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        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
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            <begin position="381"/>
            <end position="393"/>
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            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="440"/>
            <end position="471"/>
        </location>
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            <begin position="472"/>
            <end position="481"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003706-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="500" mass="53655" checksum="6BA87D3D4366A37E" modified="2014-10-29" version="1">MGKVNAISAADEQEIAEARGSTLPDMLYDVMARAAITSIGQFVYKRIDNLLWTVEKTARWSLPQNPPIMTEKTATSEKVSPAVAGTEESEDAGTNISGPPLIRPLPWLLFLPALIVLRLIRTVLSMGAKVIGRGPVLPTTMVGFLQNKRRKLRALKYRGQRLQRISRHEGASEESPQGIASTWLQRIILPLKMVICTRPYRAADNNSDVAHAVVFRKDQPSTAAQKRTVPVSKKRNLNQREAESDEEGASDEDSFEDAGYKELLDKYANADDSSFNVEDISSPSDDSSSSQSDADPSPKKPTLEADKKLNGGSQQAAVAPKPETLKRSASEHKNGIDASAGASKNSSSAKSVNQPIRSQSAAELEKGNNTQSSASVGTDGNSNAASSSTSTTTPSKSIPNLTSSPENNENKPINHNIPGVAAGPPMKSPTPTSLKPLAKQSPTMSDVRSTFQQQKQPTLGTKASHSVATAPQQQTNQQQQQHMTNGGKSRNKKPSTQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGR8</accession>
    <name>A0A084VGR8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004369-RA">
        <property type="protein sequence ID" value="ASIC004369-PA"/>
        <property type="gene ID" value="ASIC004369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004369"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16847" checksum="863522CE76D89138" modified="2014-10-29" version="1">MEVTQKKRMQCDKLGSSAAEHKRSNQQGKEKKWTKAFKNIRAGRIRSIHCIRKCPPEPIVRSTVLFFSLFRSPVPSHPVELPKRRVTSPVVDGLPGAKTGYEIAGQERTTGRTQNTIIIAHLQERAAFYARRIGKPHRPARFSSSSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGZ4</accession>
    <name>A0A084VGZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP000343-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00004453</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGZ4"/>
    <dbReference type="STRING" id="74873.A0A084VGZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004453-RA">
        <property type="protein sequence ID" value="ASIC004453-PA"/>
        <property type="gene ID" value="ASIC004453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015283"/>
    <dbReference type="OMA" id="MAKVKWD"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="65"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="758"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115948" checksum="3188996EB30D20E1" modified="2014-10-29" version="1">MEKMEEIKYKVLELINKKEVKIPKMGFTDYYTNQQREQLSMRNASAIGSSGSKLGLNKLSDQEVLESTEVIYFDGNSNTGLHELRKIAEQDKQLSCRSIEESIGILKRQHRVISKKVLQLILEQRVACDAEFQRIRDTEQMLRETVCMCRTARLKLDTAKLLLTTTNLEILAAYKKRQTLVNLLRIMNALKSMRSIDQRLQRRLTDADYGGAIAILLENKNLSRRFYQYRCVESLSHKLQDTLLLTEVQLDCVLSEIPSEFEPTRYRKLQEAYHLLGKELIAMDQLHMNFISSVHTAAYTVLKQHMDVNVEESKKLTYEQMCDCVPADKYVHCLTALCRAFWKILVSYHQIRCWHQNHSLYEKGPAAMSSGEPLQTPNHGQQASSFHQEYIQQKLESGQFRLWNDVQGKVCVFISSSRLHSLKYDQFVQILAIVQRLKKVGFEFCDSHSEKLLGAMQKQSMVFFKRYHIACLEEIGLFFDHEVWVPISSFHDVTQLQEYKNFRHALARTVTNRAGASVTGVRGSLSGASKGGDNVVTRGVDLIPDSTSSMHSQDESSLYGSCVYFLRFTEKSSPFDGGFDSTMLEEDILAGIADESSYYYSEDSSDNNEQSPTSPALVAASFDGVPGEESPSSQNHSKTTATGGPNGGASAAPNLPVVVVNTSLTVLRCIGRYLYFCKLLHRITPHIVRSMAELIDYYIFSVHDLFSADLNIPRDNLYSARLRAALQRIKVELLPMLRRSWPLSDEMVRADLSDPDTMYGIHKRIVATESCLTLVAQFRQMENYLGGLLATPAGDAGQQPGDTPSAEDGGWTQASLREYLQQTAEYVPDIRKPIVMCSTARVVDLQGILQMMTKVKWDINHVNVQHSAYVDTINRGVQYFAMKLEDEISSVTLPRDVLWDSFVHVLTHLLVEGFSNAKKCSAGGRALMQLDFTHFWSLLEIVSGGKHPEHRAYVEQYVKAYYLPKDLLQEWLLEPHGYSTKHLIGLVQCACSSDKKTRQRLLALVESSQDNSSTSLATSGQAGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH27</accession>
    <name>A0A084VH27_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-AMP-activated protein kinase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00004492</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH27"/>
    <dbReference type="STRING" id="74873.A0A084VH27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004492-RA">
        <property type="protein sequence ID" value="ASIC004492-PA"/>
        <property type="gene ID" value="ASIC004492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004492"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023539"/>
    <dbReference type="OMA" id="MYATSIV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="4">
        <location>
            <begin position="167"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="238" mass="27015" checksum="8BE788F6324A98DF" modified="2014-10-29" version="1">MGNAASILRKERFKSEANDSISETPLMEEQGLVFDETPISMQDQQGDGVQSATVPTVMRWDGGGKKVYVSGSFSKWKALPMIESLGDFFTIVNIPEGDHLYKFLVDGEWKYDPKMKCVEDAGVTCNLVTVGQTISEYSKRSSRTVKKRTMLIRRSGVNIFQRQTHGARNQARQFFHPICWRLPPTKTLHYRESPILAEPNSSTLNHMYATSIVDGVMVLSTTQRNRNKNVTRLFYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHE4</accession>
    <name>A0A084VHE4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP002007-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013162">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHE4"/>
    <dbReference type="STRING" id="74873.A0A084VHE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004686-RA">
        <property type="protein sequence ID" value="ASIC004686-PA"/>
        <property type="gene ID" value="ASIC004686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004686"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011145"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021642"/>
    <dbReference type="OMA" id="SHNDVEY"/>
    <dbReference type="OrthoDB" id="27267at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783675" evidence="9">
        <location>
            <begin position="28"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004686-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="514" mass="57509" checksum="74EBB0F3DB703B7E" modified="2014-10-29" version="1">MQSISTGRTLMGLMLVLLVTLPYTTVARSFEKQTLRKGKSAQIMASAPTITTPLMDLCSEDINMKLACHCSPESHAKAQKASCSIFDGELPRKDYNWLAFHTQTELEHLKFTVRKSGNLTYIPSDVIATLQKLRTLTIEYGIIADIYPFAFGNLTELRVINLPNNQIVTLHANAFAHHRSLEELMLENNYIKKIDRDAFVDVPKLIKLNLANNSIVNLHDNGFEELTKLEELRLESNQISVLAREYFKGLENLKILKLSHNDVEYLGAFVFADLWSLQMLFLDSNRIEKIDERAFDGLTSLNYLHLENNHITTFDVATFTSVSALLLLNLDSNRLTTMTYGHIVPLMDNLVNSSALLSLRDNRFICDCRLAWMYDVSERTRNEELRESLKSIECILGQPSEETTRSPQPGAYDFGQLDEDGDYIEDSASENDALAKEAPQTVNVLKLGREELPCPEELAGPTGDPNPRESKGLFNLSWNSSAAGDRYGSSSGGKLLLAIATLLATVGLCRSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHL8</accession>
    <name>A0A084VHL8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00004599</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHL8"/>
    <dbReference type="STRING" id="74873.A0A084VHL8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004599-RA">
        <property type="protein sequence ID" value="ASIC004599-PA"/>
        <property type="gene ID" value="ASIC004599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004599"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012635"/>
    <dbReference type="OMA" id="RCICLES"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF5">
        <property type="entry name" value="FI02094P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35362" checksum="83F5365C30F06F0F" modified="2014-10-29" version="1">MSSDWLVDASEEDYSSDDAEFHNAENNSEQTIDAIHRALQRFDWPDYVVFVVMLLICVVIGIFFGYQDHRKHKGKQTRRDSEALDYLVGGRKMQIFPVSVSLVASWISGISLLGTSTEIYVYGTQYCYIVVAVVLMGFVLHYIFLPVFHDLQITSAYEGGLKAVVWTDVIQSGVTLLALLAVLIKGTYDVGGPREVLDRNIAGDRLEAPNFDPDPTLRHSFWIILVGAPIWFCYGVSCSQDMIQRFLALPTLQDARKALKGFIVGWIMVNVIFFPHWNAGVRHVLPVRSTYDPVGQSKGSTVASVLLPSVRFRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHQ0</accession>
    <name>A0A084VHQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004716</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004716-RA">
        <property type="protein sequence ID" value="ASIC004716-PA"/>
        <property type="gene ID" value="ASIC004716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004716"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9607" checksum="584300FC9ED57044" modified="2014-10-29" version="1">MKMLLLLHKADGIYALPDAGMRYVCEKNVAKFSHPSECNVISLPHIGSQPEGNNGYEKHPVAKLSSNRHHRKLGGFKMKPKSPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHX7</accession>
    <name>A0A084VHX7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00004808</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHX7"/>
    <dbReference type="STRING" id="74873.A0A084VHX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004808-RA">
        <property type="protein sequence ID" value="ASIC004808-PA"/>
        <property type="gene ID" value="ASIC004808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004808"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003920"/>
    <dbReference type="OMA" id="EPHSWIH"/>
    <dbReference type="OrthoDB" id="6247992at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB37571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004808-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="273" mass="31773" checksum="A2E37D976C837B63" modified="2014-10-29" version="1">MFPIRTVPSGAASQCFTLIRSLTVGSVRAAKKAEQLESEASAAEEDVPVTFVDDDAESAEDREARLGAIRNKSRLLPQHRNMLHDTLPYEESQSWIHETVKYKRMMLGRYGLEGSRVDPRICFPTKKEVYEKAEYERVAFPFSLKQMMDANAAARKAKKAAVEAREVEIARKLEKLDQWTADLNARMEKKEAEARAAKERKDRLVEEVRRHFGFKVDPRDERFQEMLTQKEREDRKKVKEAKRKEKEEKMMEKLQKKTAELEADIEVPNEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIJ1</accession>
    <name>A0A084VIJ1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00005102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIJ1"/>
    <dbReference type="STRING" id="74873.A0A084VIJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005102-RA">
        <property type="protein sequence ID" value="ASIC005102-PA"/>
        <property type="gene ID" value="ASIC005102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005102"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011697"/>
    <dbReference type="OMA" id="QWKVTDE"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="159" mass="18042" checksum="650987063369C408" modified="2014-10-29" version="1">MLNKRNSSSAVPAPLVDKQTIETVNKQLATRSEGRLFAVVQLAGKQFKITAGDIIVVEGYWPPENGDRLRLDKVLLAGSTDFSLIGRPLLAPGLVDVQATIIEKTLSHTRTHFRKKRRKQYVRINFYRTQQTMIRINSIDITRKLGESSPQESSEDRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIR1</accession>
    <name>A0A084VIR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013381">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005160-RA">
        <property type="protein sequence ID" value="ASIC005160-PA"/>
        <property type="gene ID" value="ASIC005160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005160"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005160-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="236" mass="25820" checksum="96F9876699A39FE8" modified="2014-10-29" version="1">MEGIQIAPIEGGASEHRTDSERLCWRHPGIVGNRPWVGSWPSIFRIILGPIPGTLRPYIIRGAASECQTTILITGDTAAVLICIHTRAVRTGLANTAALQNGPETSERLDRPAYRKDGQNPGVNTGQEILKPSSGANMPLPRGYGAVMFARVKIWHCQLRQPAIRSVELFSFPPPPCFPCGRICEPGRSTDRPNGKHRRSILQVRTDAMVMMMSLFKTNPILPTPGAGLIKAFACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIR8</accession>
    <name>A0A084VIR8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005178</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005178-RA">
        <property type="protein sequence ID" value="ASIC005178-PA"/>
        <property type="gene ID" value="ASIC005178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14673" checksum="DD60426D293E8040" modified="2014-10-29" version="1">MDRKSGNRQRRVARSDSIGCRLSSAERRTFSQCHASAAFGKPLERHNHATGLATEACDMAVRLTDVHRLRRGSRELGKCVIQNVLNSARPLAREVTANSSPVALPKPKLTVAPPTPDRKRGKGCNCRGTAEQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ60</accession>
    <name>A0A084VJ60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Potassium/proton antiporter RosB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005280</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524859">
        <property type="protein sequence ID" value="KFB38004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005280-RA">
        <property type="protein sequence ID" value="ASIC005280-PA"/>
        <property type="gene ID" value="ASIC005280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005280"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="14860" checksum="D49B169AE643E2FE" modified="2014-10-29" version="1">MKHPRRRMEALNPPTESALGQNWGGAQANSFVPLATDRTFEHGNGGASIHHNALTCRQRASLWSCTGNTAEFHHLPSICCVLGINHAVCPIPGLLESPGGLEIPSLKRGLFVEVVHTPTKDSLLLPADLVRIIGSENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJA5</accession>
    <name>A0A084VJA5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003703-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005326</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524864">
        <property type="protein sequence ID" value="KFB38049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJA5"/>
    <dbReference type="STRING" id="74873.A0A084VJA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005326-RA">
        <property type="protein sequence ID" value="ASIC005326-PA"/>
        <property type="gene ID" value="ASIC005326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005326"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005326-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="33456" checksum="7E8D49C9FA064512" modified="2014-10-29" version="1">MAYKLNNNATEKGHASETAHSLDTLASHGYTATTSTSYLGLTAPTASHYGPTTQTIHALNIGHTALSTHTTPSSQTTVTKHSSFLGNTSPRNGTDAYTLHLTSSIPHMKDEQKFDRATGVQLLEANILIQRRFRTKRLLGRDREEFEQKKIAAVVIQCLFRGHHVMIRERDRFVAVRRAAVVIQQYFRAHVAMVQETQRFQQIRQETITMQARWRSTILMRAQRSVFQQNVSAVRIIQTHYRRYRADLETRTGQARFQYYHRRMSIVVSASWMRFDYRPGGTGRIIGCSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJV5</accession>
    <name>A0A084VJV5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010331-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00005568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJV5"/>
    <dbReference type="STRING" id="74873.A0A084VJV5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005568-RA">
        <property type="protein sequence ID" value="ASIC005568-PA"/>
        <property type="gene ID" value="ASIC005568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005568"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009997"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10228">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000495">
        <property type="entry name" value="Heat shock protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="796" mass="88526" checksum="0959046F7BB704B2" modified="2014-10-29" version="1">MSVIGIDFGNESCYVAVAKAGGIETIANDYSLRATPSFVAFAGRNRVLGVAAKNQQVTNMNNTIGGFKRFLGRKFNDPHVQEELRSLPYQVEPTSDGGIGIRVNYLDEEHVFTPEQITAMLFTKLKEDASKELKTQINDCVVTVPSFFTNAERQALLDAASISGLNVLRLMNETTATALSYGFYKQDLPGPEEKPRNVVFVDCGHASLQVSACAFQKGSLKMLASCSDSVGGRDFDMKLAMHFNKEFQTKYKIDASSKKRAFLRLLTEVEKLKKNMSANSTKLPLNIECFMNEIDVQSSLQRSDMEEMCSDLFGRIESTMRKLLSDSKLALEDIHSVEIVGGSSRIPAIKQLIEQIFGKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFSCTDVQAYPVLISWDDSDGPHELKVFEQYHSAPFARMLTVHRKEAMTITLKYEPNSVPFPDPFIGSYQVKGIKPDANGEAQEVKVKVRINGNGIIMLASATIYERKESEEPASPGANGEQKAPDASGQQPSSPQEGDDASKGGEPMDVQEDKKKKVTTKHVELTIESKVHGFLSADLHKFFEEERIDAKNALEEQVYEVREKIQEDGALHQYIEPQEASEICRELEETENWLYEDGESCEKGVYKERLEKLHAKMNPVRNRCEEYSGHEQAFTELGYSIQQTLKAVEQYRAKEPKYDHLTETEILNITEAAQKAQKWYEDARTKLVGARKTQDPPVKLADIRHETQTLTTCTNSVLNRPKPKPPTPPADQQPNGPSSNNNAGAAGGDQQDSNAPKQTTEDSMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJZ7</accession>
    <name>A0A084VJZ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013480-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524923">
        <property type="protein sequence ID" value="KFB38291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJZ7"/>
    <dbReference type="STRING" id="74873.A0A084VJZ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005631-RA">
        <property type="protein sequence ID" value="ASIC005631-PA"/>
        <property type="gene ID" value="ASIC005631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005631"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005926"/>
    <dbReference type="OMA" id="PIDYPAH"/>
    <dbReference type="OrthoDB" id="8065722at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783478" evidence="2">
        <location>
            <begin position="20"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="695" mass="76918" checksum="7B247C46697F9B2B" modified="2014-10-29" version="1">MEFHLRKITLTFLLGLTLAEKQNATEQSVAPANNGAKEKRQTEHETRSIPLSLIANRRQQAALHHQHAQQQQQEYYQSEEAAGPFYGAQPNGGQVALAYKSSAGQKAGASQEQPQYQELPPEYISLLHQLAEHQPKAAAVKQGKAVSQQFEPQSHAQHSKPNQVQYITEEEYAQLVKQAQQQAGPAGPPPPQHQQQQHHLHHQHQAPPQGLQAYGRPSSHPGASHKYRPSIQLLETGEDQPGAYGQQEGEQYRVQYKSIQQAGSVTPVPKPVSSFSFEKELAKLVESNRPIAYHHPAPPHHPGRHEVQHDGQRYGPTPSPQSHEYTYVQAGGPAHDHAAPPQQPKQSIKAQYIAPFAQGLPLTGPKISPAHLQVGPQRFVDSPAQKYQFIGNPEAGSPKAHHHAQQLHQQQQQHHHHQAPAHQGQQYLTEVSPKQLQGTPSPKIQYYIPKEKNVQVYYQQAQQQQQQQQQQQQQQHHLQQAYEQHSPQHPMKIVEAPQLQNEKPQKTAQSHHRSKPAEQQQQHQHRYAAREKQPEASPVSSDAHAPSRSAIFVSQSTGVNQATAAATPAPAGAHYGGEKHAHKIPPKIDRPLTQEEFQALVDAGYSVVPVPVPVPVPISQYQQHQQAAGHPGAGRAHPTPASSSAARQQAAQASRYHLHQLATAENNPNQVVTYLRPLHLDPFSAGVRGPHKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKD0</accession>
    <name>A0A084VKD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005787</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524947">
        <property type="protein sequence ID" value="KFB38424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005787-RA">
        <property type="protein sequence ID" value="ASIC005787-PA"/>
        <property type="gene ID" value="ASIC005787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005787"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005787-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14725" checksum="2DBAC6080DDFCC8D" modified="2014-10-29" version="1">MHHVVTSALPEQPRSPVRLCAAASYNTVERLRGWNRHHDTNDAELVSRSSLSVAREFPAPFHPPNGQFIGDTVQHPQTAATTAVRWIRSLLLVPSTLEPLLGRLLHITNKHGRTVRFWCAVGPFWCVFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLB0</accession>
    <name>A0A084VLB0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP012792-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006154</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLB0"/>
    <dbReference type="STRING" id="74873.A0A084VLB0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006154-RA">
        <property type="protein sequence ID" value="ASIC006154-PA"/>
        <property type="gene ID" value="ASIC006154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006154"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007947"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000738">
        <property type="entry name" value="Autophagy-specific protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006154-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="344" mass="37801" checksum="000F780F20EF2C60" modified="2014-10-29" version="1">MNLVDCNPYGNGLLYAGFNQDQGCFACATDNGFRVYNCDPLKEKERQIFPDGGVSYVEMLFRCNYLALVGGGLRPLYPPNKVLVWDDLKKAPAISLDFNAPVKGVRLRRDRIVVVLEGIIKVYTFTQTPTQLHVFETSKNPQGLCVLCPNSTKSLLAFPGRRTGHVQIVDLANTEKAPHEIIAHETAISCIALNLQGTRLATASDRGTLIRIFDTSSGTKVAELRRGSNQAKIYCINFNHQSTSVVVSSDHGTIHVFNLEEPSKGRDGGPSGGGVGGSNLLARYFTSQWSFCKFSIPQGPPCICAFGSEMICADGHYYKFVYNNKGECSREVCSQFLEMSDDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLJ1</accession>
    <name>A0A084VLJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000607-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006321</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006321-RA">
        <property type="protein sequence ID" value="ASIC006321-PA"/>
        <property type="gene ID" value="ASIC006321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006321"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002484"/>
    <dbReference type="OMA" id="ASTAWHE"/>
    <dbReference type="OrthoDB" id="7733843at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783787" evidence="2">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006321-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="389" mass="44149" checksum="6A66EF0C06C31F6C" modified="2014-10-29" version="1">MEKLTYRCLYVLSLLWCVAHAAPNPTEQKSSAQGNVCGQHYNDIYAAAKSWQTKGIVPEHETQYKELKEKCAQAHKERQEKQNAVTTKLPTYMSNIVVALSSLNSTLRTEVSTLEEIVQNQHESLANAWQYGLELQHELLVTNIESDRIEKALLYHSILQDSSPKQIVTESYAYHGSHGKMVALLLKFVRSLPAKTERVEAYTELERLLKSNGQNERFPAVIFSQDVKELGDQGYNPDHTQLEGKAVARWQSLLLAGNFSEIVLFAQDHPSYYARIESTLIDALNKAWSKEALEKVIYFPNVLPNSSQRVAALKGVLKTLLAHQDKQLNDLYLMKLAKELEKLEHHVEASGDTQAKESLKEVKDIFGKFSYTRNFSNYVDLYGMLKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMU1</accession>
    <name>A0A084VMU1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006637</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VMU1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006637-RA">
        <property type="protein sequence ID" value="ASIC006637-PA"/>
        <property type="gene ID" value="ASIC006637"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006637"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014685"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022078"/>
    <dbReference type="OMA" id="WQLGGSM"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000109">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000178">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000258">
        <property type="entry name" value="centaurin-gamma-1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000025">
        <property type="entry name" value="luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="435"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="13">
        <location>
            <begin position="690"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB39285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006637-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1512" mass="164458" checksum="52DFE47D18E08C83" modified="2014-10-29" version="1">MTKEENNSFPCSTVDSFVNSQEWTISRSVPDIRLGIVGSLSSGKSALVHRYLTGTYMHEESPEGGRFKKEIQIDNQSYLLLIRDEGGPPEIQFAAWVDAVIFVFSLDNESSFNAIYTYYNRIAHHRKTTEIPFILVGTQDGICERAPRVIDDARARKLAQDLRSTYYETCATYGLNVERVFQEACQKIVQQRLSTGSTITPTNSRPTTPQGTRLGLASFHPATQLSVPSPTNGFTSGTNAGSSPANVGHAVANSSPSHQQQQTGGGGGGMTLPHRHHALSASSHHIPIKVSAELIAAEVQHHQNTAAAVGAGNGQKWGTISHGTSQQALLALTNENNNIAKFVPPMHPVSSAGGPHNDGLQSLGLPTGKDSGSGGSGSAKDSGKDGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKEQQQQEKIKNGELGSGRAIPIKQGYLYKRSSKSLNKDWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEVSLQYVTVKVPGQRPRGTKSIITNSALTAAAAQAQAAQASSNGTNGQTNGLTEGIGGLSLAKDRKCTEKVLLTAFDTLREPVKSNSQTSGDEGIVISNSNSQSFLGSDSNTIGGGGGGGSKIDAQTPNVKKRHRRMKSSGVGKNSEYDDSDGFEFYIVSLDNKQWHFEASNSEERDEWVSVIEQEIFKSLQGIESSKSKPLNPSDIASMQSIRSRVPGNGYCVDCDSPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDEWPPGHLSVMLAIGNSLANSVWEANTRGRVKPTPASSREEKEAWIRSKYEGKDFLPPFNPSPPIGQQLCEAVVRSDMKSIIILLANATHEHINSTASNRDLRTPLLLACAIGNLAISQLLIWHHANLKHVDNEGRSCLTFAKAANSLAAAKQAMNSPHHVNVETTAALVELLTSLGCTDPAPFSASGTLPRRRETIDQATFEKFSSIVYESSLECHLESRQKFRMLGMESAGRTRYDPSGQFWYGERLPPVWNPAAGLGRIILDSLARSPDKVIQINADTGRRTTCAEMRLRIIRVALHLRRLGFRKGEFVSLACANGEHVVPVFIGCLVLGLAVNPLAPVFNREDFAHMMRQTQSRLVFCDEANRAVVEQAVKDAITAKDVRLFDTGTGVTSVEKLLQPIEGEKDFRVEYLGDATKLLALVLCSSGTTGLPKGVCLSHAHFVDEMVFSTEISDGPIFSFSSLFWATGLFGVTTSLLYSRPRVFTSSPFSPELLLQVIEKYRIETVFTPPSYVSALLAHPRLSKADLSSVRSWQLGGSMVAEELLLQMQPHLPNAHMRSIYGSSEIGFITRCAIPVSVPTSVGSLGTNVECRLVDESGKVVGPGVQGEVLVRHRYMFLGYLNNPEATKNALTEDGFFRTGDIGYMDADGNLFVIDRIKDIIKYANYQISPSDLEGIIQKIDGVKQVCVIGIPSADRSSDLAMAVVERVPGSNIREEDIVRIVDGQVADFKRLRGGVRFVDSFPMTPSGKILRRAVKQMVNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN26</accession>
    <name>A0A084VN26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000209-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN26"/>
    <dbReference type="STRING" id="74873.A0A084VN26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006795-RA">
        <property type="protein sequence ID" value="ASIC006795-PA"/>
        <property type="gene ID" value="ASIC006795"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC006795"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006733"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="9845" checksum="CD434D8FB05B46DB" modified="2014-10-29" version="1">MKLWKSKKSTGAASGTAGTTTTSCVPGSGSTKGAGILAKTCKFNSSSTNGGGSAGNGSSLDDSSAETSFINQGPAGGPSELNGGTGVPVAMVQHSSGNIFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN70</accession>
    <name>A0A084VN70_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008089-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006940</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN70"/>
    <dbReference type="STRING" id="74873.A0A084VN70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006940-RA">
        <property type="protein sequence ID" value="ASIC006940-PA"/>
        <property type="gene ID" value="ASIC006940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009024"/>
    <dbReference type="OMA" id="CTVITYD"/>
    <dbReference type="OrthoDB" id="6414280at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783837" evidence="1">
        <location>
            <begin position="28"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="364" mass="41182" checksum="D159185DEBEEF2A4" modified="2014-10-29" version="1">MRTKPFLLILTCVLMTTFLLILFGSAGQQDDSLKNIVSQTHQHLRNFKQNLRESNSDRRPEIDPKYLAQLGFTQPLYNGTRANFTVVTYALPGELASTLLFVQNMAFKLPTQPLLVYDLGLEESDLHTLQTFCNGSSSGAPSHCCSVITYDLNKLPPHVADRSMHAFRPIIIHDALARSKLILFTENNVRLKGSNPARDIEDVRLRAENSSSGVLGCATKQPVTSRTHPKMFEYFETGVDNFYFLPMTSLEFVFFRNSATVNEKVLLPWVRCALTLECLHPIGAQSGGCKYNKKPLYRYSGCHAYDTCAFNIILGMTFGYDESNYSNQDLANLYYLETLEQATKILENRRKNISDTSEHPFTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNE7</accession>
    <name>A0A084VNE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP008035-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006987</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNE7"/>
    <dbReference type="STRING" id="74873.A0A084VNE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006987-RA">
        <property type="protein sequence ID" value="ASIC006987-PA"/>
        <property type="gene ID" value="ASIC006987"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006987"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005883"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017609"/>
    <dbReference type="OMA" id="EKDKQPC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000042">
        <property type="entry name" value="Kinesin family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000050">
        <property type="entry name" value="Kinesin-like protein, KLP38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF5">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="174"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="564"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB39491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006987-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135603" checksum="A884A285E2110988" modified="2014-10-29" version="1">MNRFGTAASSSPTKASTPRSVLRPGGSKLPTSLLTKRTCPLNTSSSESLGASPARTPKTSLAGPGTVGGITMAKSKSSTTLNLNNCFTPSSRPPAASSKSASKDFGTPRNLLKRTKAREDLLNARTPECFAPISVDSPLPAGAKHRSSQSKLDESCRSTTKEKDKDGSMGEMSNLKVAVRIRPLSVKECIDSVSNIVRVKNNEIFIHGGSTADNSAGVEHAFHYDHVFWSCNADDPAYVNQAEMYNTMVHPLLDKAFEGYNTCLFAYGQTGSGKSYSMMGMDLDDNYDDAPNPDAGIIPRFCHELFARINALKGKVHAEVEVSYFEIYNEKIHDLLSVTPTDGGFVVSTPGRGAKKPPLKVREHPVWGPYVVDLSTHPVDSNTSLRNWLAVGNSQRATAATGMNDKSSRSHSIFSVVLNLVEIVESSDPNDSGRSAGDGPTTVKQTKRSKISLVDLAGSERISQTCASGARLKEGVCINKSLLTLGKVISALADPKKGANTYIPYRDSVLTWLLRESLGGNSRTVMLATISPASIHVDETLATLRYARQARSIVNRVKVNEDPHDRIIRELRAKIERLQVLQQEHERQRRLSEANQHQQYLQPRKIIIETTVDDGEVESLRQQLAEMEQELAKAQRSWRERLQEAEDVRRTEMKLLKRKGLALELSAEQKEPCLVNLAADPMLSGTLLYIIPPGTVLIGRPSSLSSPDIVLEGPLVSPKHCVIENKNGMLYIIPEPNTEYETFVNGELIQERRKLLHGDRLVIGGSHYFRISNPLCPNKTTQVMVDFQLAHQEILREQENRLRQELDAEKQATLARIEAERMAQEQDYEERLASLELEKFRYKYRKELLETEQEALLQSTGKRDKLNSPKGDRSIEQDSFEGCEPSAESNLADEIRRIMEHTSDESLAHIQMMVKEASQRCRDVGLEYEFKQTQVWQDEGIFRAMVNIVDRVNGRVAEWFPARLECWLGFVRDRDDLTADNMFEPVDLVWNDAGDQSANESLLQESHNSSRISLNLGSVKDAILGRHSLVSNSSTTSCGSPSTGPVGNSRKSQGLLKSMFTKASMDAANEHARAAGGSARKALFTGPDDNDENIPSNCQRTSATKAAPPRRFDQKASQYLRDIHLATLKLRKLCEKQQDSAGDMMDVDGESGHREDAQKESRHQSRDFDEALANQCLESIGNIERSLQTIRSALTEHNIKEATLNASESDYGRTPKAVRFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP48</accession>
    <name>A0A084VP48_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007892-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007435</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014977">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP48"/>
    <dbReference type="STRING" id="74873.A0A084VP48"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007435-RA">
        <property type="protein sequence ID" value="ASIC007435-PA"/>
        <property type="gene ID" value="ASIC007435"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007435"/>
    <dbReference type="OrthoDB" id="10070392at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007435-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="249" mass="27642" checksum="514047C9B5E82B59" modified="2014-10-29" version="1">MFQWPTDNSTLTDERNLSSATRSASKSQQLLKSGTVDSGNALPGNEPSATNASQPNKDGVSKESSNEKQLEEKPVPKDSVTSSNNNNKSISINNNSISNANSPFWDSAVSSKQSSPERLPSMNGADRSVIIEDTEQVKVNSSFKTSQVEGKNFTLFRRGSLRRSKKSHPTVTTRMNRKFQAFVDRWLEQHVSVGQKSSCNDWLLGKHPDLAKNLTTVVIVRDKNATRTPYRPYNRYKVESMEVADGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQT3</accession>
    <name>A0A084VQT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007816</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015320">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007816-RA">
        <property type="protein sequence ID" value="ASIC007816-PA"/>
        <property type="gene ID" value="ASIC007816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007816"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007816-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="10276" checksum="2BAAB24F88FBFC9C" modified="2014-10-29" version="1">MEEVARLNLDTGTLRLESLDIRIFLRSYQLAAFLPVVFSIERKTVLTSHDIQAAFQHRSGWRHQLLHPVLRHDRRLFPGNRTGSGALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRL9</accession>
    <name>A0A084VRL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP011530-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008123</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015746">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRL9"/>
    <dbReference type="STRING" id="74873.A0A084VRL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008123-RA">
        <property type="protein sequence ID" value="ASIC008123-PA"/>
        <property type="gene ID" value="ASIC008123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008123"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007463"/>
    <dbReference type="OMA" id="TRNIKPY"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF4">
        <property type="entry name" value="GH11294P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="49"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="531" mass="60785" checksum="3097E333A4D26C99" modified="2014-10-29" version="1">MLEEDEKIEKICSVCKKEASKRCSRCALVFYCTTEHQQQDWKTHKSVCHPFKICSNEQFGRFLVATRDIKAGEIVLKESPLVFGPAQVTGPVCVGCLQGLEEKKHLECEKCGWPVCKRSCQDHPTHQAECKFTIARGSKVSIQHYYVPHPTYQCLMPLRCLLLSETDPAKWDALLRLESHDEERRGSEQWRNDREGVAKLIPRFFKCENKWDEDEILRVVGIIHVNGHEVPLTEPSSVAIYNMASMLEHSCRPNLSKSFTNRNEIVIWAPNAIRRGERLSICYTDVMWATGSRLEHLQQTKMFRCECERCSDPTEYETYFSALRCSGFQKDGKCKGYLLPVDKSEWTGDWSCVRCHKEVTGATVCQILERARMDLEAMQKHREDHCNKYIKHYSKWLTPNHQFMVDVKISLSQVIGGNNPEAIKKIPFDKLMNKIKICQELIALFEKICPAEARAFGATRFELHSALAELGRRSTESNNPAASVQLEDSLYNATECVRMLLHEPSALMESKICAQAKQNAETLKALLGIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSH6</accession>
    <name>A0A084VSH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP002734-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008460</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525051">
        <property type="protein sequence ID" value="KFB40920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSH6"/>
    <dbReference type="STRING" id="74873.A0A084VSH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008460-RA">
        <property type="protein sequence ID" value="ASIC008460-PA"/>
        <property type="gene ID" value="ASIC008460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008460"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022733"/>
    <dbReference type="OMA" id="DWCHFVQ"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="443" mass="50517" checksum="FF8D79FCAA5CC48D" modified="2014-10-29" version="1">MAIFLKTLRPHCDRIFSKRSTQLPLALSSFQFTTRVKCELDTITEKDITENGLKPRKHRGRIKCNNIALPAEIQDAILKSAKDYPIKSLINDGQRLHNCIRSRKWFPLDDTIAGRRKGAASEREVPSSAQRQKESVFDMHDTYSCLTQLIGRSDAEYAVLKRIFTEISQRDPELRPRSFLDFGSGVGTGTWAVTQFWREHLFEILSVDKSRHMNDLAELVLRQGDPNKATMVRNVFYRQFLPANPNRKYDIVLSSFSLFDQSTRRGLLELVDQLYATFNKYLIFVEQGSNAGFQLLDGIRNHIRKNHNADDSHLFAPCPHSLPCPRIAADDGTPCNFEATYTRTFPSGDGHQYGSILYSYLVYKKNPPDSAQGFPRLVRPTAVRSKHCVCHVCAADGKLRDVTFTTAKHGQVIHRCAKASRWADLLPMHVEWEDKAKREDGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSP9</accession>
    <name>A0A084VSP9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008605</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSP9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008605-RA">
        <property type="protein sequence ID" value="ASIC008605-PA"/>
        <property type="gene ID" value="ASIC008605"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008605"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008605-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15278" checksum="4AAEEFCD81AAEC13" modified="2014-10-29" version="1">MEAKTERAGNATSASSFVHVVQRCLEFGTNFFLLFVRFKRFAKGPTTQNRHPASDSSASGKDGAIACDGTVFEVEFFRNIPIDWLAIGGGVEKGLICSQVLQLGAQWFAYRSRAVMVWQLKRDEALATRSKGSKRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSX1</accession>
    <name>A0A084VSX1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011225-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008519</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSX1"/>
    <dbReference type="STRING" id="74873.A0A084VSX1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008519-RA">
        <property type="protein sequence ID" value="ASIC008519-PA"/>
        <property type="gene ID" value="ASIC008519"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008519"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011074"/>
    <dbReference type="OMA" id="NECYTAN"/>
    <dbReference type="OrthoDB" id="7734170at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008519-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="221" mass="25737" checksum="48686A86E03CCF16" modified="2014-10-29" version="1">MMRNELKNLTSSVLRLSSCRQAPSKLSGKYVIQVNETKFDVFCEQTNFGGDWIVIQHRFDGSVDFYRNWTEYRNGFGNLDGEFWLGLEHLYQLTKNRPHELIVELKDFDGNYKYARYAEFEVGGESEVYVLKKLGKYAGTVGDSFAGNKGRKFSTYDRDHTLRKCAVKQYSGWWQKNCSNANLNGRYEKKDGDMSSMIWWDFKGGNHGLAFSRMMIREIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT71</accession>
    <name>A0A084VT71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Myotubularin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008726</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT71"/>
    <dbReference type="STRING" id="74873.A0A084VT71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008726-RA">
        <property type="protein sequence ID" value="ASIC008726-PA"/>
        <property type="gene ID" value="ASIC008726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008726"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006071"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="17845" checksum="0F77305643C75351" modified="2014-10-29" version="1">MLMTHVLFAAFRSCQITRDIAAVDHLIIRCKRLAQMLLFRCQHVGGNRVNVVPPRPRIMEGSGTGSPQSSLCMVKPAELFPKPALLKDDEKLTVPFTELAGEGVHYLGQTDDGILALSNYRLFLQKNSTGAEVSVPLGLIESTQVRDLFHLIVNCKDASTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUI1</accession>
    <name>A0A084VUI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009254</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525120">
        <property type="protein sequence ID" value="KFB41625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009254-RA">
        <property type="protein sequence ID" value="ASIC009254-PA"/>
        <property type="gene ID" value="ASIC009254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009254"/>
    <dbReference type="OMA" id="GSFREYN"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="352" mass="37700" checksum="1F72A9DD42AB30B7" modified="2014-10-29" version="1">MRLKIPEIVAHPFASQKVDKLILEETEAGRRFLATLRRNHEKELLEAGGESHPSPAQPDDGSTIVVARSLAKDKRSSLRATLEHLIVRYLRRLTASGDEDENGEDNGEAARYRRQSPMGHDRTTSTTTTVGSLPPPEGEEPVGGTAGPGVISSSMEITLLTNDTDTNLTDAWDGSERFQQQQLKDSGHGYGLPGSSVSGQSGEKGVELAHESGARRDTAWDRSVGASAGQERVPPHGANGGGVSGSSESVENTASEGQQQQQGADVSATHDKLRVGDGDGMPLGVGSDPGVMGTGEGHVKAPGSGGGLRRQKQRECGNVRKRVSQLDRFELERSMRNGSFREYNIRNALNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUZ2</accession>
    <name>A0A084VUZ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP003352-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009442</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017130">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017131">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017134">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525156">
        <property type="protein sequence ID" value="KFB41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUZ2"/>
    <dbReference type="STRING" id="74873.A0A084VUZ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009442-RA">
        <property type="protein sequence ID" value="ASIC009442-PA"/>
        <property type="gene ID" value="ASIC009442"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009442"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012596"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13435">
        <property type="entry name" value="SPFH_SLP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="118"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009442-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="459" mass="50517" checksum="9060EC410242C27A" modified="2014-10-29" version="1">MDWTDRTVVEDQHSVDGLRGIDFRHDQQPAHQQQHLLQQPLQQPLLQPVQQLHPYLPQSTAPSPLPPPHHTPPALAIPISDALRHRTAEADSIGCVEVLATVCSIVLMVLTLPISLFLCFKVVQEYERAVIFRLGRLRSGGARGPGVFFVLPCIDNYCKVDLRTVSFDVPPQEVLTRDSVTVSVDAVVYYRIRDPLNAVVQVANYSHSTRLLAATTLRNVLGTRNLSELLTEREAISHSMQVTLDEATDPWGVQVERVEIKDVSLPDSLQRSMAAEAEAAREARAKVIAAEGEMKSSRALKEASDIMCESPAALQLRYLQTLSSIAGEKNSTIVFPLPIELIGPLMNFTSSLGIQRTTAPLAPRPRRPSQTRRTISRRSISSSYREYTCSDATIINTDGIRITTTITSSSSTNTTSGPGTTSQAAVTGSPPNPAPRRTPHPRRKIPPSARPPTVWRDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVH9</accession>
    <name>A0A084VVH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000392-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVH9"/>
    <dbReference type="STRING" id="74873.A0A084VVH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009543-RA">
        <property type="protein sequence ID" value="ASIC009543-PA"/>
        <property type="gene ID" value="ASIC009543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009543"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000795"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="22591" checksum="613449E471F14BDC" modified="2014-10-29" version="1">MVKLYAISVFYKAPTEARLLKSAYDLQSFSFFQRGSVQEFISFASKTLVERTQAATRQSVKQDVYMCHVYVRADNLGAVLIADHEYPQRVGHTLLTKVLDDFSAKVSSDQWAVTTNEAAIQFGTLPATLSKYQDPREADALTRMQEDLDETKIILKNTIESVLERGEKLDDLVYKSESLSIQSKAFYKTAKKTNSCCNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW13</accession>
    <name>A0A084VW13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009821</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017370">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009821-RA">
        <property type="protein sequence ID" value="ASIC009821-PA"/>
        <property type="gene ID" value="ASIC009821"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009821"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009821-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8350" checksum="D5DBB5173DD89098" modified="2014-10-29" version="1">MMNIRIRQHHRTAIVTTHSRLRNIPHHQHHNYHQLAPSVIGSGCLGASFLTTPSRGGASAGSALELGHDRGRGEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWG8</accession>
    <name>A0A084VWG8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009998</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009998-RA">
        <property type="protein sequence ID" value="ASIC009998-PA"/>
        <property type="gene ID" value="ASIC009998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009998"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009998-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="10027" checksum="FFD39AD68EEFA027" modified="2014-10-29" version="1">MFGRMNFATAGPRFGFSVCSTTVYSQVDRRAKWTYVYSRGHSLRSTVRPTVSGVGRWKRALVYNPEQCGAVHGENAHQSGYGRGRYHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWY2</accession>
    <name>A0A084VWY2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010180</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01017808">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525192">
        <property type="protein sequence ID" value="KFB42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWY2"/>
    <dbReference type="STRING" id="74873.A0A084VWY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010180-RA">
        <property type="protein sequence ID" value="ASIC010180-PA"/>
        <property type="gene ID" value="ASIC010180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010180"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002662"/>
    <dbReference type="OMA" id="ENATHHQ"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000046">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF14">
        <property type="entry name" value="FI05488P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="215"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010180-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139528" checksum="EA286073800BBC61" modified="2014-10-29" version="1">MENCNAPEVSSETVPAGSSTRFTSSKLKRAFSMPRNPFQGSRSSTPKVSSAASITTARNRRLGGGYSNDNEAAASKTSNGDGNGSNNSKYVMSDVSSTTDTSRLYSSDSSGQQVGAQNASSNSNNKLKTPSEPDAMAGPRDGDGERVEGRSDKKIFRRLSVKKFINRIAQQMTYVNRTVVQSSQKATLNGSVGRAAGNGKESAFVWPPDTVPGVIGLRNHGNTCFMNAVLQCLSHTDILAQYFVLDLYKADLKRRNKINAKKFGTKGELTEQLALVLKSLWTCKDAPDYSSNFKAVVDRYGSQFRSSTQHDAQEFLFWLLDKVHEDLNTATKRKYKTIKNNGRSDEVIAAETLANYVRCNNSFVQAVFQAQFRSSLSCPTCGKQSNTFDPFYCLSVPLPQLSQQPVLVKVIYASQQPKQVKLGLGIPHGSPVLALREQLHADTGIGLDRMILTEICETGFNRVLCDSHLMSSVNENDPLYCIECPAGLATGQQDASSGTKILLLLCNGKRLANGSIDKGNGNGCVKRFGTPFCLIVNRDISYSELQKLLLKEMSSILRSDVFTFATPAQNLFRMRLQDPSCDADTWLETTVEHPLFTEMIDLALSVLPSDAGPAHVKLLIEWTEPERFFSDMSDAFVEHESVCQMKEKIPASSTLTLEQCFEHYTKAETLGPDNAWKCPHCQEYLPVVKTLGLWSLPDIMVIHLKRFRQQQLRSSTQAAKLTNLVKFPLCGFDMTPHLVRDLSLQKTPGAPANTAQNENQHRGYSDSDSWSPWRKIKRSGPSTQSHSTGGSGANGRRQFAMDNRYDLYAVCYHQGDTLETGHYTAACKNPYDGQWYRFDDQRVAHVPNDRIDEEIINNEAYLLFYQRRKLPINNGVGATGECSGSSSSSSGDHWVSKIIVPPPVISHTASAVAATVDQGIKSTPSSSIAASSSSTTTTASIPETENKSPGASIVRESNKNTLVDTKLTADSGPPVSAFAEKPVVESIVEVQNGLHQVNNARALAKEQYYFQDVNRSSNEERPSLEMKKLTVDTNEKPDSISPKSTMHLPALSSSAVPTKVYEENAKEAKESLEAEEMVIEKLTLQQSDTTTTQSSPSMEEIRPLKIETSTNNSTTGTASKMLEANGIVSKEQFSLRLEKLDRMVDHKLGGNNSSVIHSTGGRFSLPSSQRYQDILWRENVSEIIHHRPSSFATYKSVIDANDAVSLIRGANTCSKDTLLFIDQQGHGLDRVMLDDDDDDPDELLPGSGSRTLWISPVTPHKLITVSPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYJ5</accession>
    <name>A0A084VYJ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010714</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018370">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYJ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010714-RA">
        <property type="protein sequence ID" value="ASIC010714-PA"/>
        <property type="gene ID" value="ASIC010714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010714"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010714-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="199" mass="21310" checksum="D27ABBBA7E339311" modified="2014-10-29" version="1">MYRAPSSQTVNTKRANVPVRKPRTVQSPPRAIAGPGRLFPSARTCEHRTVGTALPGRVESSRVGSSYHSPPPPTPSSWCPRASIRSSRSSSSSLDVHDTTKRHVHFTGPFPLHLAGVKLAALSLPCARSAKPAVPGTTSARVRMEGRPKNPVCGRDGCPLQKLTDARATRHERHPSDGVGKDWGDVPGGSTLRLLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYM5</accession>
    <name>A0A084VYM5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00010749</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYM5"/>
    <dbReference type="STRING" id="74873.A0A084VYM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010749-RA">
        <property type="protein sequence ID" value="ASIC010749-PA"/>
        <property type="gene ID" value="ASIC010749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010749"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007687"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000014">
        <property type="entry name" value="conserved oligomeric Golgi complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1970:FF:000002">
        <property type="entry name" value="Oligomeric Golgi complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="11">
        <location>
            <begin position="167"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="767" mass="85961" checksum="3680276649C2F8A2" modified="2014-10-29" version="1">MIKLESFIGDSDIGTSAGIEDVCEKISKKEQQIDSRLEEILSQQCQLEAKMRSIGIALTSLNVVSDKSRHLSEMINHTASLAESVSAKVRRLDEARSRVSECQQRVHDLIDLQLCSQGVMTAIREEDFEQGAAHVNRFLSMDKTLLQKTADDVSGSITSVSKAVSTLEQATVQIQQMVNQKFDDAVKRDDLASVERFFKIFPLLGMHDEGLEKFMTYICGKLAAKAAKELRSSMDIAKAEKRTAVAYADTLTILLENIARVIEVNQAIIENCYGPGRLVQICRILQRECDDEVTKCVQEFNRNRQTGRRIAQINDYIKSAGNSSSAMGHYRKASGGGGSIDKLNAKDIDSLIGEITIMHSRAELYVKFIKRRCTNDLEKSSLSPEVKEERLAELNTLLQKSRLNTQMQELLGTYLLFERYFMEESVLKAIGLDKLEDGQQCSSMLDDVFFIVRKCIRRSNGTQSLDGVCAVINNAASCLEEDFLKALKAPLKAGYPTGYIDLAQAYNAFQSSIQQGRLQTSDSDHARGRFIAALNNADMSTEFIETLWKMMAEEVEITFPTMTAREKEKLDSCLGGLKSFGDSLKALVDFGFQQLRSSAIKPRLHPWVDQFLTHNHNLTEEELATYEAGETFVQFLIVQIDGLLNSFKVALTPRNFDALVSIVTTEITTRMERAIKKTTFNRMGGLVLDQEVRALASFLTGATSWSVRDKLAKLLQMGTILNLESVSELPEYWESSSASWRLTANEARSILALRIDFKMEDIKKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0C1</accession>
    <name>A0A084W0C1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011391</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0C1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011391-RA">
        <property type="protein sequence ID" value="ASIC011391-PA"/>
        <property type="gene ID" value="ASIC011391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011391"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011391-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6531" checksum="83F38AB6FC5BA3DC" modified="2014-10-29" version="1">MLRVHEAVTELEDARPRYRERTSFGVTTGAAESLATAQPPFRNHPIPALPYWCACGMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1A6</accession>
    <name>A0A084W1A6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004701-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011829</name>
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    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB44000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W1A6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011829-RA">
        <property type="protein sequence ID" value="ASIC011829-PA"/>
        <property type="gene ID" value="ASIC011829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011829"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013043"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013410"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016542"/>
    <dbReference type="OMA" id="CITSTPH"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032057">
        <property type="entry name" value="DUF4799"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16056">
        <property type="entry name" value="DUF4799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="574"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="849"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1745" mass="190692" checksum="E01676344CBB9E18" modified="2014-10-29" version="1">MLKWTVTKRSEASGGNVLSQGQVLMQKRRHARRSLGALSERIEAAGRNAVSNDGAGNGLATHHQIKLRRSLGTAVHGVANYDKENQCITSTPHPMTSSRTLDSPYSTALRDVSNITPNTTPCRLSTVSTPQSRKRTWATSPASAGQKRAPNQEITVLREPYATTLPTFDIEYSPCGGKNVPFLAIRGLGMTEFENPGRYFPTDDEEPSSKRCKVSEKQSMSDETAPKKAPVGAPGLTPLSSRFADLRFNKGSFKRPRSVAKTVNNNHLPPPETGVDAPEETNELSLNSSEMGDITLDKMIDAILESAKKDTRWATPRPKRSSSIKSKQSKGSSPTYTPADDPATDLYLLERRLPARIAQQAGDTTIILEETSHVNEREVKTPEPIREHQTTSSTRRGFRQSLNKLVLASPLEAACHLRRQKAVRRKHGKQESGGHPPEGGGVASIPRKDMQGRGASKSPETPNVAFSHSRIDQLALIKTPVHEGVCIFAPEEGTVELQKQQEQQLVSATATPSIRSIDLQGTSTPTESIEKTRKCLNFSPTLSEDSLEKRGSVASSMTSRCSRAGFVLGTGPTVRGTLELSIGFDQTGRLQVHVIRCRDLQRTQTGSTAGCNAINAYVKVALTNTGNTGSVQAGHTEFGPFQRTAVHRNSSRPIFDHRFFFDIQPDDERRIQLAVWHRDRECRRSEFLGCISFPVQSATKQDINGAYHLQPQSCLTNPIAPLPDTMCENSQSSVDEIVCAVDTTSSAMSLSAGVAAGTAPEGAGVTNTANTDHTNGASEPLSLSKKALHQRDADENLFLRFLELDPSPEVAPSGGCGNLPVPATPRRNSVCSSTKPASASLGRTPFTITKRLARTGDRGFGFSIVWTHPPRVEKVESGLSAEKAGILPGDYVVFVEKHNVVTMPEQDVLNLIRSQGNTLLLEIFRRPQQAGGQQSRSNGLRNSVTGPANPSVVGSSNAINFPPLNACAAIMPSLLDEPSLKTAAPYGVARSSTACSNFSIETAKRKLHLPQVTFSKESIVQPFPDDHRRKFLYQLISREQHFVNAINFGIERFVNPLRERKDLISPNDHKTLFQNIDELSRISEDILEQIIQDDTEPHIHFASRVYLSKSTALCAAYRKYCNGLKKADCVLVNKSRNSNCDFMKFITEPPVPRKRPDLTTFIHRPLQHFREILKLVQMIASHCRVDSEEHNNFNSIISELQIAYREITVGGGLMEPIGEGRPLLTLQDLEARMVFTKCKPFQLASHGRQWIFGGDLSRVEGRSIKPYWTLLFSDILLFAKVSRDRVLFITEEPIALSTITDSCFNIRKKSTEFRITTDPNGRQIESPTVHCAPDLTRTPKKSSKKRYIVLRAPSTELKAVWQNLLTRQIFLVNATLGSTPLSSPLDSPDILQSLVPISDIGATATTMASVKVPSLDSIHLKNQQVCSLGSLAQAPSCHSVSSASFHNASATVLSGKGFNGNVGKKLSTLSGRSNTVESRSNRSVTTIQGSISELPELILLHQSTNNWAMAGLATSRLHNGPLTKTNEFANDEINQNYITTSGVNIECENISCDDLPSSTVSSADVSNAQRGMVTLSSRDRILQSFSRGSRDNMRSIVEFSLSSVGRSFIDNADDSDPDRQSTSVAEEYVPTPETPPPNVSPSSSNKVSDTFSNDFKETTTPPSASVSPIAGDAGGQITNADCSKYLLASGYGGSWDLLELDLDFHQVNYDPSFGNDVTETEFLGDDDDPFGMLPTQPTPPNLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L9</accession>
    <name>A0A084W3L9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3L9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012722-RA">
        <property type="protein sequence ID" value="ASIC012722-PA"/>
        <property type="gene ID" value="ASIC012722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012722"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018876"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20033" checksum="2415AAFA70ADAE17" modified="2014-10-29" version="1">MLNLERTIAPRKIHTSCREHCCRKKKFNRSIDPAALENVVASSLTSSPSSSLSSSSSASAAGAASRPRFNSVTVTSSAHRSPSVQPNRLQSLESAYHWTTGPPSPGSVRDRTSCSSGGINVLYVEAQELPLQATNNIKTKQISISNNRTIIPWLYRVGLIETKHPLCVGALIHPSLILTTAVCVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3Z8</accession>
    <name>A0A084W3Z8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525296">
        <property type="protein sequence ID" value="KFB44942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3Z8"/>
    <dbReference type="STRING" id="74873.A0A084W3Z8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012853-RA">
        <property type="protein sequence ID" value="ASIC012853-PA"/>
        <property type="gene ID" value="ASIC012853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012853"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010774"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="17610" checksum="283E86774C39B9A0" modified="2014-10-29" version="1">MPPKFDPNEIKQVYLRCVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATGDWKGLKITVCLTIQNRQATISVVPSAASLIVKALKEPPRDRKKVKNIKHNGNITFDEVISIARVMRPRSMARELSGTCKEVLGTAHSVGCTIDGRAPHDVIEDISSGAIECPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4W1</accession>
    <name>A0A084W4W1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013200</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4W1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013200-RA">
        <property type="protein sequence ID" value="ASIC013200-PA"/>
        <property type="gene ID" value="ASIC013200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013200"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013200-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11108" checksum="A1BF4C5B29A1EB2E" modified="2014-10-29" version="1">MSDQFWWVPPSGCSENRLSTRRAAINCPEMMLMMMESAPQFQARGSTSDMTASVSGISHSIATTKAVSNRRFGRLQFVGAMLWSILQAALGYKFRFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W502</accession>
    <name>A0A084W502_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001532-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013240</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W502"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013240-RA">
        <property type="protein sequence ID" value="ASIC013240-PA"/>
        <property type="gene ID" value="ASIC013240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013240"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013240-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8311" checksum="921E998384A68300" modified="2014-10-29" version="1">MYLAAGLLNIMDITLQHEYLQEYYQSAAGLANFSGTLPYGLGGLPPNGSGLQGAVDKNGSEVTIAAPGTVRVSSKAGVTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5E3</accession>
    <name>A0A084W5E3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00013370</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01020597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020600">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020601">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020602">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020603">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020605">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5E3"/>
    <dbReference type="STRING" id="74873.A0A084W5E3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013370-RA">
        <property type="protein sequence ID" value="ASIC013370-PA"/>
        <property type="gene ID" value="ASIC013370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013370"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020261"/>
    <dbReference type="OMA" id="EFDWTHK"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000703">
        <property type="entry name" value="Casein kinase I gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022247">
        <property type="entry name" value="Casein_kinase-1_gamma_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12605">
        <property type="entry name" value="CK1gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="59"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013370-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="452" mass="49704" checksum="7A11D9E23D5C7524" modified="2014-10-29" version="1">MKVNYLSGVPGAGASNTAGGGGGGGGGGGGGGARGGSSMYSARHSVSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGAHDTQSPPEGIPRVYHLGTCGGRYNAMVLELLGPSLEDLFTLCGRKFSLKTVLMIAKQLVKTHPHTYEHSSVSVSNGRDENFLIGRNSNKRDKIIHIIDFGLAKEYIDLDTNKHIPYREHKSLTGTARYMSINTHMGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIDVLCDGHPEEFAKYLRYVRRLDFFETPDYDHLRRLFQDLFYFKGYVDDGEFDWTGKTMSTPVGSLQTGHEVVVSPNRERHTPANKQTNSKGGVAAWPDVPKQTGTLGNLTPADRHGSVQVVSSTNGELNADDPTAGHSNTPITQQAEVEVVDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5L3</accession>
    <name>A0A084W5L3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP010269-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00013447</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5L3"/>
    <dbReference type="STRING" id="74873.A0A084W5L3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013447-RA">
        <property type="protein sequence ID" value="ASIC013447-PA"/>
        <property type="gene ID" value="ASIC013447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013447"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004697"/>
    <dbReference type="OMA" id="WQNHVGA"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="669"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB45507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013447-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121956" checksum="34615D3BDE6F1E4C" modified="2014-10-29" version="1">MDNYGFKEDGDTIPPSTPPLRPPRILRTTSYIENGSNKFPRLSTRFNLSSTKWGQQMDAEAALVSPAMMVNGLGGEGTVLRNSFNGVTTATTANGHGAADKAPIVANGAATVPKSTAPATVQPIGGRKSHIDSYEYMEVGPSPPAESAPNLYDSYDETYSESSAQLCNDIIRISITEQMRLAGGRVTLLECFETDDTLDRATVEQLFKSAAPAVPGTPAASKAPNDPTSGSGPGIGSQVEKNICFLWAAFLRKFPLLEQCVELGAELTFCDSNGLTALHLAAFSGCTECCDFLISHGQDVNWQPKWYTPLHCAAFGNSLATAELLIKNGARIDVATNKHHCEESLLHCAVRSNAIECLRFFIAHGADVNALERNGTNPIHLAADLGHTQCLAALLESPAADPNVRIQQGDKQMTALHLAADEGNLECVTLLLAKGADVRARNHRGFTPLHLAARSGSADCVEALLKLGGCDPNVADFDQRTPLHAAVSKSDAAVEMIETLVAWGANVNQRDIYGFTALHLAALDALGPCVETLLFHGADVTMKSRKGTSALNIISRKTPASLGVIQCKLDAAITLTHSQDSSSREVELELDFRSILQHCHPREISYLNTFVDDGQKEFLQHPLCSAFLYIKWNKIRKYYIARLLFCFTFVLFLTLYVLTALAHNCYNGSKDMKETTQEQELCQKQSIFGELLRNNPFVIEMQWMVLVAITAIEICRKIYGITGYTSLRHYVTQTENAIEWFIILSVFVISYIYTKRTYTWQNHVGAFAVLLGWTNLMLMIGQLPVFGAYVAMYTKVQVEFAKLFMAYSCMLIGFTISFCVIFPSSSSFANPFMGFITVLVMMTGEQDLELLINDPDGKDPPFLLEISAQITFVLFLLFVTVILMNLLIGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGWLPNWLRNLLYYTALVSPQAYRVVLSVKPLNPGETRLPRDIMMAAYEVAKQKKHYVRKSFSTLRRNMTYDPLLPAATNGIKSTVYDRSDSSNTAPSDRRDRYHNGTIGVNSTNSEHSAKFGYVYETPTLYGITNKLDEHTETIGNVASEIAELRASLEQTQQMLRQVLQLLTKNTKLNIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W687</accession>
    <name>A0A084W687_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dsim\GD15247-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013701</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W687"/>
    <dbReference type="STRING" id="74873.A0A084W687"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013701-RA">
        <property type="protein sequence ID" value="ASIC013701-PA"/>
        <property type="gene ID" value="ASIC013701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013701"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021739"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013701-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="18810" checksum="65EAC97DEC95D9EC" modified="2014-10-29" version="1">MEPLGWIHTQPNELPQLSPQDITTHARIMSENPAWDGEKTIVITCSFTPGSCSLTAYKLTPSGYEWGHKNTDKGNNPKGYLPSHYERVQMLLSNKFLGFFMVPAQGSWNYNFMGVRHDPNMKYELQLANPKEFYHEIHRPSHFLLFSSLEEAGDGNGADREDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6U2</accession>
    <name>A0A084W6U2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DDX42</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAD box protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00013901</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX42 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01020948">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525310">
        <property type="protein sequence ID" value="KFB45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6U2"/>
    <dbReference type="STRING" id="74873.A0A084W6U2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013901-RA">
        <property type="protein sequence ID" value="ASIC013901-PA"/>
        <property type="gene ID" value="ASIC013901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013901"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006772"/>
    <dbReference type="OMA" id="DHTWEQT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17952">
        <property type="entry name" value="DEADc_DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000524">
        <property type="entry name" value="ATP-dependent RNA helicase DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="308"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="512"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="666"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="752"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013901-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="802" mass="88906" checksum="F5541FFC9E5D63DE" modified="2014-10-29" version="1">MNRNRGNFSFQMRRTGPHRPNQQQQQHSKDQNRSYSLNAVPPPSSLCGRSSGVPPPKSYNQGPGISKHGYHTIESIHQYSNPSQYSVGKRRGRTEDEYFEEEDEPIGQPLEYIPAPGSPSAADSSVSSSDDDDDDDEEDPLDAFMAGIEEQVKLENKKIPQPNVDPKKGTRGDIDDEDDEESYYRYMKENPNAGVLDEGSDAELEYDEDGNPIPPPRRREIDPLPALDHSEIDYAKFEKNFYIPHEDIVNLSHAKVQELRQTLGVKVSGPLPPHPVTSFAHFGFDESLMKAIRKSEYSQPTPIQAQAIPAALSGRDIIGIAKTGSGKTAAFLWPMLVHIMDQRELGPGDGPIGLILAPTRELSLQIYGEAKKFGKVYNISVCCCYGGGSKWEQSKALEQGAEIVVATPGRMIDMVKMKATNLQRVTYLVLDEADKMFNMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIIHGDLGEANSDVTQRIMLLPNVQSKWNWLLTNLVQLLSEGSVLIFVTKKADAEQVANNLRLKENDVVLLHGDMDQSERNSVITRFKRREVDIMVATDVAARGLDIPHIRTVVNYDIARDIDTHTHRIGRTGRAGEKGTAYTLITDKDKEFSGHLVRNLEGANQEVPDDLMKLAMQSSWFRNSRFKQGNKGKNLNVGGAGLGFRQRPVHRGPLSRPSDASASGASTEDAAAGIPQAPGSSKGPATDRLSAMRETFRAHYNAQFKASTDRTWENTVPEGGVFAKPALPGFVPPSGNNSDEQSSSDSANNDSAPRKKRSRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8X7</accession>
    <name>A0A084W8X7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8X7"/>
    <dbReference type="STRING" id="74873.A0A084W8X7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014580-RA">
        <property type="protein sequence ID" value="ASIC014580-PA"/>
        <property type="gene ID" value="ASIC014580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014580"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006038"/>
    <dbReference type="OMA" id="FGCANDA"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014580-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="387" mass="44621" checksum="F07226212F96383B" modified="2014-10-29" version="1">MATSHHYDRRFGWVYPLFQLLGLALVPLHGQSLGSLYTLTSVIVSSYVLLILCVAVYSLAYPGDLFFLSDATGTFADAIQFEILLVVPLVSLILSLAKRPLQQRIARLMDQLDGQLEANASEPGLLERFNYTMSGDVLTTVIIYNVIPAANEMFIISRISANIIWYRNWLLKVWFLMLIRLGDTLFLVHVQYVRNRYRLLNYELKQTRSQPDAITHRRLVRLKAVQNLLKDLTGDVSDRFGWQLFSVITMLFICTTIDGYWMYASLYHDGNLYKTESFLCGISPFLMFFMLFNVCQHCVDEGELTFYHLHNVLNRPLPPQTIQNFSKQLNNEKVNFSAANFFELKLSGLTTIFASITTYLVIYINFLPKTDTFNDYNKEHNLVNSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W972</accession>
    <name>A0A084W972_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021647">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W972"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014768-RA">
        <property type="protein sequence ID" value="ASIC014768-PA"/>
        <property type="gene ID" value="ASIC014768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014768"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022578"/>
    <dbReference type="OMA" id="GAWRSFK"/>
    <dbReference type="OrthoDB" id="8186735at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784463" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014768-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="20545" checksum="6C287E7BE6E7ABA6" modified="2014-10-29" version="1">MLKCTQTWTLVIATLALSCLISAKILISKVDYESNPNYLTMNVQVHNETEGSTVDVDGMLYVDVYQGIHINIDIDSKMDGEYMTMIGTSKELCSKEESGIDPVVPLLNEELEKFGNLSFGCPYYKGLYRMRRFRMSNDHMLVKMVPPGEYVLKMDLKHQQENDTKMAHVYKLSFFFEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9H5</accession>
    <name>A0A084W9H5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014895</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525323">
        <property type="protein sequence ID" value="KFB46869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC014895-RA">
        <property type="protein sequence ID" value="ASIC014895-PA"/>
        <property type="gene ID" value="ASIC014895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014895"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16587" checksum="DC2700FDF0A328D8" modified="2014-10-29" version="1">MESYGNIPTKARVGRNGLLVAVCNHRRMHIIRALQGFATPTEYIAAEQQTISMQIRLLRRPHTGGCLVFAATGQPYDPWLCPVPEMASEIXXXXXXXMDAWWLRALEVRDGGQAKLSGFVVKRPFNFRFPDPSTGDKFSSLEVCQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Q4</accession>
    <name>A0A084W9Q4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004795-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Q4"/>
    <dbReference type="STRING" id="74873.A0A084W9Q4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014961-RA">
        <property type="protein sequence ID" value="ASIC014961-PA"/>
        <property type="gene ID" value="ASIC014961"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014961"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014961-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="15194" checksum="8E7E3412FE5F8C79" modified="2014-10-29" version="1">MAALCAGNYGLSQQGSLNDENKELIFVKLTDSALRAIEEFQRTQAKLGTSHNPSIQFLQNGQGFLSFPSGGNNVQKFNFSITDIDTGSIECIQQTQGQLQNMGHIPHKMRIHANDDVYETTRHRLAAAEENQKNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBC1</accession>
    <name>A0A084WBC1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hyaluronidase</fullName>
            <ecNumber evidence="8">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00015473</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01022343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBC1"/>
    <dbReference type="STRING" id="74873.A0A084WBC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015473-RA">
        <property type="protein sequence ID" value="ASIC015473-PA"/>
        <property type="gene ID" value="ASIC015473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015473"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019579"/>
    <dbReference type="OMA" id="FPSIYMD"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001329">
        <property type="entry name" value="Venom_Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00847">
        <property type="entry name" value="HYALURONDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="352" mass="40659" checksum="028C8920D7123E96" modified="2014-10-29" version="1">MNKDDKFSVCLWTFEVYWNIPTFMCNQFGMDFTGINQTYQVIQNTNDSFRGNAISILYDPGKFPALLERPSTKTIYKRNGGVPQDGNLTEHLELFERHLDELIPDQNFAGVGVIDFESWRPIFRQNFGSLQPYKDLSVRIEKERHPFWSAALVDREAARRFEATGREFMERTLLMAKQRRPRAQWGYYAFPYCFNMNGGANGGRENCSPEVQKENNRLLWLYDESDIIFPSVYLRQKLSPSEREQLVRGRVREAVRVAQRTIGSKPRRKVLTYLRYVFTDTVKYLSESDWISALAAMKSTGSDGIILWGSSFDLNSRQKCSDFKTYLETTLGPVLSSLRPRSTVDNPPGAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBG2</accession>
    <name>A0A084WBG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00015520</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="ATLV01022351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBG2"/>
    <dbReference type="STRING" id="74873.A0A084WBG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015520-RA">
        <property type="protein sequence ID" value="ASIC015520-PA"/>
        <property type="gene ID" value="ASIC015520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015520"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003333"/>
    <dbReference type="OMA" id="QEPKEVW"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="453" mass="51083" checksum="8F9B52961E432149" modified="2014-10-29" version="1">MMRYEGNEELADKSACAGVRADLKMCLLQIPREGFGPGMQDWGYAEVRPGAHMFWWLYYTTADVPNHADRPLVIWLQGGPGASSMYGNFEELGPLTLELDERNHTWVRDYNVLFIDNPVGTGFSYVEDFSLLTKTNGEIAADLVELMKQFYTLQPEFRTTPLHIYAESYGGKMAPEFAYVLDKAIKNGEIDCNLQSVGIVAPWVSPIDSVLSWAEFLLNMGFVDTKGFRAIQASAIETEHVLNQGDWEEATNLWGRTENVILRETHGIDFYNVLFKQDYASTRSQLEQFSRDMRSAIASRATRLATEDRDQMLEDLMRFEVHPALSLPAESVYGAQSGRVFNTLAGDFMKPAIDVMELLLNNTSLDVVIITGQLDLIVATPGNVRWIEKIQWEGQNSYLQAPRNAVGQHGVLEGYEKVYGKLSVYWALRAGHMVPADNPILMDYILQKHVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD98</accession>
    <name>A0A084WD98_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016264</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022977">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD98"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016264-RA">
        <property type="protein sequence ID" value="ASIC016264-PA"/>
        <property type="gene ID" value="ASIC016264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016264"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="130" mass="14808" checksum="326D8A336B53A544" modified="2014-10-29" version="1">MQENDEEIEKKLAFDDHTRRSLWFADGYVLRRVKHKNTPNIRAPSAISRAHVRTRDHLCFRMLPAGCDAERGLGKGPRLITPPGENREANRAQCLESGCIWAVEVFGHLPRLLGAELYNRCSISVSKIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE16</accession>
    <name>A0A084WE16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP004951-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00016444</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023102">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE16"/>
    <dbReference type="STRING" id="74873.A0A084WE16"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016444-RA">
        <property type="protein sequence ID" value="ASIC016444-PA"/>
        <property type="gene ID" value="ASIC016444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016444"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003861"/>
    <dbReference type="OMA" id="PWHESLG"/>
    <dbReference type="OrthoDB" id="7788383at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF43">
        <property type="entry name" value="ODORANT RECEPTOR 47A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB48460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016444-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="382" mass="43514" checksum="A4A8BAFEF3B2EDC6" modified="2014-10-29" version="1">MAFSEHHLPESHFRYLRYCGVYPRPTVGSRLRVWYTCVLLCIFVPLHLAYIVHNSTSDLMETCEEIMLMQVCTTAMLKFNIFFSNREKMYALLEAFKNIHVRFGEVEELYRFVRCHDMHAKLRRIYIISTTVVASLYVLNAVTASVTLSLQSGTLRFVTPMNFPYNYQHPVVFGLSFIYNIETMIMTMCISVTVDTCFSELSNDLALHFDIVGKRFAKLDFSAPVSTTAERELIRLIGYHGELLELAGKMMQQFQQVIFFLLLMVSTILCVLGYEFVIVTSVSKRLQVVAMAAVFITQAVIYTYNGSLVTEKSAAVSEGIYACNWYEASPAIKKTIYFCLMRAQKPIVMKSGFIEATLPTLKKILSSSGSYITMLLSLESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE83</accession>
    <name>A0A084WE83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016836</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016836-RA">
        <property type="protein sequence ID" value="ASIC016836-PA"/>
        <property type="gene ID" value="ASIC016836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016836"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016836-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6727" checksum="DCD5FEAC728F6684" modified="2014-10-29" version="1">MPICQVLYRVFNTKTTFASGRDNNESYSQAMPTFDSKSSTGSVHHHQQQQQQQWPAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEM6</accession>
    <name>A0A084WEM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023229">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEM6"/>
    <dbReference type="STRING" id="74873.A0A084WEM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016667-RA">
        <property type="protein sequence ID" value="ASIC016667-PA"/>
        <property type="gene ID" value="ASIC016667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016667"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022861"/>
    <dbReference type="OMA" id="APNWANM"/>
    <dbReference type="OrthoDB" id="7789933at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016667-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="158" mass="17658" checksum="F1389477071792B6" modified="2014-10-29" version="1">MTGLILDGPKLANDGPLKTTVTARHVDAASFCLSQAIEIPPGIFKFSSADVQASEHLLHASVLSMVEFDDDIFAGGNCFDWNQHPAKRGLFCPFAYRLPPPDQGASLVKDLALEYHYLGNTSEWFFLARKNAEKVIARNEQYIKYKISIQRNSIALKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFQ5</accession>
    <name>A0A084WFQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ubiquitin-conjugating enzyme E2-17 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00017061</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFQ5"/>
    <dbReference type="STRING" id="74873.A0A084WFQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017061-RA">
        <property type="protein sequence ID" value="ASIC017061-PA"/>
        <property type="gene ID" value="ASIC017061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017061"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022956"/>
    <dbReference type="OMA" id="PNIASMY"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000002">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017061-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="14499" checksum="AFAE7770D9E627E3" modified="2014-10-29" version="1">MWWLMFSDGELHRHPKQPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFT4</accession>
    <name>A0A084WFT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017256</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023401">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017256-RA">
        <property type="protein sequence ID" value="ASIC017256-PA"/>
        <property type="gene ID" value="ASIC017256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017256"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="10871" checksum="012094ED8ECA1F56" modified="2014-10-29" version="1">MYLFLQDESLLTPRLIYHSGLHLSAKRVRAELSVQSLLATHSVAGTHDNSVDARHESILPGRVRGSCIGSYPSQPTPPEKNIKPSLTGAAPEGRGRGSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFW8</accession>
    <name>A0A084WFW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AGAP008626-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00017264</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017264-RA">
        <property type="protein sequence ID" value="ASIC017264-PA"/>
        <property type="gene ID" value="ASIC017264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017264"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021628"/>
    <dbReference type="OMA" id="VINPWAD"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB49112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="255" mass="29020" checksum="532C5DE7454558A7" modified="2014-10-29" version="1">MAKSKTNDGYQRGVYGALLKLMHFIAAVQFSYGLYYDFVYVHFPPELKRPGGEFGGKLKFLTIWDAILQAVYFTICLLNDFIGTNEVAPKRMPLIRKVKDYMLAAFAFPVALNVGVTFWTLMAIDRELVFPKALDAVFPGWLNHVMHTNIVIFMVLEICTSFRQYPSRKAGLTGLGIFMASYLVWLHIVHHFGGIWVYPVLEVLNLPQRIIFFAVSLIFCVGLYLLGEFFNNLIWTKELKQLRTAAGSGASKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG10</accession>
    <name>A0A084WG10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017310</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023425">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017310-RA">
        <property type="protein sequence ID" value="ASIC017310-PA"/>
        <property type="gene ID" value="ASIC017310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017310"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7785" checksum="2BF95BFB386E65BE" modified="2014-10-29" version="1">MSKGSVVDKKCCVRKLLVEVKNSNRGYETALGLNGFGKIARHLHPGVTEMATNHEQSGECFPADPFAWLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG13</accession>
    <name>A0A084WG13_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Dsim\GD11944-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017314</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG13"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017314-RA">
        <property type="protein sequence ID" value="ASIC017314-PA"/>
        <property type="gene ID" value="ASIC017314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017314"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017314-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="14897" checksum="8A1377C057AADB5C" modified="2014-10-29" version="1">MVIEPASICHLHLNVDEPPLFTGAFKAAPENGSKTAMHRCSYARCTFALDLSTAGYGLAIGRLLAYRSPSPAGPFRCSIGSKDSRTRSNPHTADCSKLQIASARRCIRPRRGAYHVLAPCRGSGISGFIVVVRLLGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG59</accession>
    <name>A0A084WG59_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RPA_interact_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017204</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG59"/>
    <dbReference type="STRING" id="74873.A0A084WG59"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017204-RA">
        <property type="protein sequence ID" value="ASIC017204-PA"/>
        <property type="gene ID" value="ASIC017204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017204"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009573"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023062"/>
    <dbReference type="OrthoDB" id="435311at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028159">
        <property type="entry name" value="RPA_interact_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14768">
        <property type="entry name" value="RPA_interact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RPA-interacting protein C-terminal" evidence="6">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="450" mass="51207" checksum="C9C341A3880D40E7" modified="2014-10-29" version="1">MEIINPGPSAHQTSVAQKIRSRDAARRFKFGSPKLVDLMREKCRIRIKEARKDEFLRKRNIAQEERAFLESIVREELSELEHDIALQDLIYKELMQDTEQWLFYEQSENYLISSYDTESVFCPICEHNVLELDDTAKTLRCSCGIRLRYDQTIETFSELLSKTIASHALRCSSNLQFFTEPIADVEHVQLNAFCLCSGGGDGSSGTEERKRCAETIHSGQFMVSHFETEGAEDDDDDLGMQMEDVKPSDLIASDNAVGLPLAPVDVCSAGAGALVPLAASTSSEQNQLARYVPRPIPLSSRSAVSQVEIDTDLSTVFNTLNVTYTQKLTSPKWNPFKGIRLRWKEKIRLNNVIWRCWHMQFIMKRKTLVCQFASPLDVDVHNTPQAILLEGKYWKRKCNVIKAEYKKWRRFNLKQPLGATNIVDTLRTLFFVEGAFQNASPEAVGRSYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGF0</accession>
    <name>A0A084WGF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017409</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGF0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017409-RA">
        <property type="protein sequence ID" value="ASIC017409-PA"/>
        <property type="gene ID" value="ASIC017409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017409"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7201" checksum="50E7A08F430AA363" modified="2014-10-29" version="1">MGLHSLPEIEIRADLNELFGHHLTRRLALMDLRYNPAGQQRPYRRPAAPPEALVKGDRLIMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGZ9</accession>
    <name>A0A084WGZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017695</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023776">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017695-RA">
        <property type="protein sequence ID" value="ASIC017695-PA"/>
        <property type="gene ID" value="ASIC017695"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017695"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017695-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9337" checksum="357A963CDF51EDA4" modified="2014-10-29" version="1">MPGRDFCIVISEPFCGNDRFKDSEGFFETSERKPGNALGDRLAANGTQSSPNLKRNPQQTSPKRCRPEDLKRRGLKLLLRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHQ2</accession>
    <name>A0A084WHQ2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHQ2"/>
    <dbReference type="STRING" id="74873.A0A084WHQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018403-RA">
        <property type="protein sequence ID" value="ASIC018403-PA"/>
        <property type="gene ID" value="ASIC018403"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018403"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001626"/>
    <dbReference type="OMA" id="VENECAN"/>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784892" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="153"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018403-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="418" mass="45487" checksum="264220AFB44C62FC" modified="2014-10-29" version="1">MFSRTVVLCTLVASLGCLVAAQDSLDDLYLSLYNLTENKNTIPDTTAAPAVTLSTAAPAARQPTCQGECVQYYLCSSNQIITDGAGIIDIRVGEDPEEESECPHFLNTCCEKPDVIEEPPLSVLTTPAPPTPAPGKSSPKCGFRNADGLGFRITGNKNGESEYGEFPWMLAVLREERVADSSLNVYECGASLIAPNVVLTAAHCVYNKQKDQLLIRAGEWDTQTRDELYAHQDRRVAEIITHEQFNKASLANDVALLILTEPFLLAANVQPICLPPKGYSFDLSKCFASGWGKNIFGKEGKYQVILKKVELPVVANKQCQESLRTTRLGKRFILHPSFMCAGGVAGQDTCRGDGGSPLVCPISGAPGYYYQAGIVAWGIGCGEHGIPGVYGNVQYFREWIDKALVDRSILAREYVYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIH8</accession>
    <name>A0A084WIH8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP011934-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00018065</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIH8"/>
    <dbReference type="STRING" id="74873.A0A084WIH8"/>
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    <sequence length="437" mass="49821" checksum="A3F2B5E5AC095C28" modified="2014-10-29" version="1">MSRMVRYLVMFCAVLGMASSSGFYIDNGIDQTVREKSVSLHERQEIEHEILELLGLPDRPNKQHVHPSLRKSAPQFLLNIYHKFTEESNGGRPRRKRFADSNNVFTIADERAIGESDVIMSFLNKANRHLPKIRHHRGGHRLWFDTAEIASDDNQLLYASLRMYKNRSAIRPWDALVHGQQIVVRASLIGGYDEAKDGHRLEFVGEQAVPFNYEGWVEINATQAMQRWVVDRVGNKGIFVEVYFAESPRKEVLPHEVGLILSNKFGRYQPFLVGYCKGPELVKPTVHSNNGGRSRSKRSVRRKGSDGGGSGARRRTDRVRNPFLERFGGSERSKSCQIQTLYVSFRDLNWQDWIIAPDGFGAFFCFGECNFPLNTHMNATNHALIQTLVHLMHPTRVPKPCCAPTKLNPISVLYHIDDANINLKKYKNMVVKNCGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="EMBL" id="KFB50069.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="97" mass="10858" checksum="8CC422B374F74AEA" modified="2014-10-29" version="1">MRGNPSTGENRDLWDFDSVRRPESFPHRALALCAIFVPLVLGPSASTPSPEEVPSHTVQLPNPENKTNSRQQKVHTANERTNEKLCHMGGKHRHPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIP2</accession>
    <name>A0A084WIP2_ANOSI</name>
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        <name evidence="8" type="ORF">ZHAS_00018138</name>
    </gene>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC018138"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS022024"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB50086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018138-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="408" mass="47372" checksum="F688846C2D2F04D5" modified="2014-10-29" version="1">MEQFGTVQRVLINKERVSGHSKGTAFVIFKLKDSAQMSCRQNLKLQIHDQFLEILEALRKKDITERTKAKLEKRSKDSRNLYLLKEGVIMAGSPAAKDVSKTDMAQRLRLEQRNNEMLKNFNRFVAKDRLTIHNIPPHFSNDDLRKTVIKHTSCKPIECRIMRDKRASFGNPLGTSRGYGFISFKQHETALEVLRKLNNNPSVFGKNNRPIVAFSIEDLKVHKIKQQRMEKSRLNNPTYQKKIEEIKQKKQQKNVSKKAANRQELQQLAAAPSVVLQKLNSKGANSADTSGIKKKERKRDIEPMITPFTGAIAKIGKSSIRSNRKIRHQADSHMERIKAERKEQRKKKVKEEHARNRLQKSKTLQKKPKLDRQELKKEDSYFKQTVGKYKDMISNITKQSTRGKWYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ34</accession>
    <name>A0A084WJ34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS_1_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018299</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ34"/>
    <dbReference type="STRING" id="74873.A0A084WJ34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018299-RA">
        <property type="protein sequence ID" value="ASIC018299-PA"/>
        <property type="gene ID" value="ASIC018299"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018299"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011051"/>
    <dbReference type="OMA" id="FTEYRNV"/>
    <dbReference type="OrthoDB" id="6414167at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF27">
        <property type="entry name" value="FI19426P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="14"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018299-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="698" mass="77160" checksum="EC9E27D16428233C" modified="2014-10-29" version="1">MEDNKTLFESKHNLSLKCVLFLFYGGLGCIYPFLQSNMSRKGFAYSEIYWISVIIPLVALLGPIVFALVVDKWATKNAFAYGKRLRILTALTLVASIVLYVLLMFAVSRTPPPEPCEPQVSFLCNRKGASIVQEKCSDSGVCHDWTGQKSGLLNLENCTYTCQQENQFESNCYARLAKSAQLAWLREQEAEQADDGLVLDLGSGQGTMERDSDDDDNDGVPDVKDRANATDLDGDGVPDAEDDDDDNDGIPDAEDTDDDNDGIPDEKDLDDDNDGIPDALEGRPATFDASSEKDAGDECNYPLDGFRCPVDKAWVKAQPAGCKPVVQCDIANPYANEDSLLHGTTCDGDEDNDGDDDEGDSTFYYYLSVRSLLDFCLLGGLTLLNTIIVIATRDPATGVADFGRQLVWGAVGWIIFFNDDAEQPYMLFVLLYTTAAVILLSPLKMDLSPAEDWWQLRTVPQKFVSAHACQKYLRRCWLPFLVAIGLGSLWSVIDSIDESHMTNLPKTDETGQDDGQRSSVFQTIVRTVLLAGDLLAIPVLIFSRRIIETFGTCKILVGAFLSLVVRFILLAFLDYALWDVVEDWLLPTTLGLTWVTLVLHFRDILPRKVSALAQALPVIAHFGLGRFFGALIGIEHHYQRLENDYEILAGVLFAVTILSVVLYRYREIVLNFLGQYIPALKPGDANSASGKAKGETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJE9</accession>
    <name>A0A084WJE9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP005072-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00018613</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024018">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJE9"/>
    <dbReference type="STRING" id="74873.A0A084WJE9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018613-RA">
        <property type="protein sequence ID" value="ASIC018613-PA"/>
        <property type="gene ID" value="ASIC018613"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018613"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021102"/>
    <dbReference type="OMA" id="GMYCAGI"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF127">
        <property type="entry name" value="SERINE PROTEASE 27-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785115" evidence="10">
        <location>
            <begin position="29"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="321"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="422"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="645"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB50343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018613-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="854" mass="96765" checksum="B0B7BD19DC64B5B0" modified="2014-10-29" version="1">MIRNWAELGRCWILWIVLVDSLSLSVLAQSNGTILREGFDLQRCGVPRIKNLRSRITEGELAVEGHWPWHGGLFHLNEYQCGCTLINELFVLTASHCVYNSATGYKLSERILRIKLGMYRLSANDTERTQVYTVRSIISHTKYMTSSHKHDVALVRLNGTVQFTDYIQPVCLDLTESIWVEHLADAEIPIVRYTDCVEQDPSTYGPLIYSGMYCAGILNGTSPCNGDSGGGMYIFRDNRWFLRGVVSFASIRAGTNFCDSFSYVVFMNVPYYTKWISTEVEAARESVRLEAETSTPKTNVSSRWDSDLTENDASLEETFFPVARMDTEGENSSPLPRRTARCGQNVTLSCVRPSNSILTYRRDVRWYKSVNGRREFLASKALLRLQPVRSHDAGEYWCTTTARSGRLLESGILLEVSDVPLRFRQNGATKSYTSYGVPTRTGFSLTQFSFEMTFKTTESDGLLFHKPTLPDLESWSYSLLLERSRLTFRMVPPGQSEKVFRTVRLNLEPDRWMTVLISCYDGHGFLALDGQYLLGFEGHLLQHRLDRFYIANAPELPNAVPGLSGCVSRVAVNEQELRLLEDASEKVGVELCDDCPTGECRDADGTGCPMEQISCINYACSDGRCDRSDAFSPERTCDFQPGTYADGLRLQQNSYASYRSFLSTALTVELQFRLHSLQDGIVLHTAEHRRGYGKFITVLFKAGRIELRFTTDAHLTTTFMESEVPLAVGRWYLLRAGFANGYVYLQVDGERKVERSVAGKLVSPERQLVVFVGGVRWKGFINRHRDVWKGLDGCIRELKLSGLPVDMVDDMVESANFAVQLQNLSWQMGRLTKVSAFRVVRRSIKGNRRMDQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJI8</accession>
    <name>A0A084WJI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005306-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018656</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJI8"/>
    <dbReference type="STRING" id="74873.A0A084WJI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018656-RA">
        <property type="protein sequence ID" value="ASIC018656-PA"/>
        <property type="gene ID" value="ASIC018656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018656"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019027"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14083">
        <property type="entry name" value="STKc_CaMKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018656-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="405" mass="44626" checksum="D9550EC69A1CCFB8" modified="2014-10-29" version="1">MPLFGKKDSGKKVRKDVKDGCEKLPSIDDKYVIKELLGTGAFSEVRLCEHKESGQQYAVKIIDKKALKGKEDSLENEIRVLKRFSAVRSDGSGVHSTGPPLVGGPRFAHPNIVQLLETFEDKSKVYLIMELVTGGELFDRIVEKGSYTERDASNLIRQVLEAVDYMHEQGVVHRDLKPENLLYYSPAEDSKIMISDFGLSKMEDSGFMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGEFEFDSPYWDEISDSAKDFIRQLMCVNVERRFSCKQALAHPWISGNAASSKNIHGTVSEQLKKNFAKSRWKQAYHAATVIRQMQRMALSSGGSGTGGSAYGRSASRISNAPSADGGTGTNADHEHQQPVQTDTTASSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKK9</accession>
    <name>A0A084WKK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018800</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018800-RA">
        <property type="protein sequence ID" value="ASIC018800-PA"/>
        <property type="gene ID" value="ASIC018800"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018800"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018800-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7261" checksum="209FAA6CE2B34813" modified="2014-10-29" version="1">MCKERLAYSDDNFGLLASSASTTGHPIHTDRFGFYGLASKRAGFAPVHTSEDPQRVIEGGCTVRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WL54</accession>
    <name>A0A084WL54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018988</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WL54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018988-RA">
        <property type="protein sequence ID" value="ASIC018988-PA"/>
        <property type="gene ID" value="ASIC018988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018988"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018988-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7472" checksum="42FFEBB406BDC677" modified="2014-10-29" version="1">MPQGGRLRNPIPIGVERNAYGGKTGPCIMPRMDPKEEAKATGKEKNWHNTAVRYGSSGSRWESCDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLP2</accession>
    <name>A0A084WLP2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019421</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Golgi apparatus membrane</location>
            <topology evidence="1 5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01024268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLP2"/>
    <dbReference type="STRING" id="74873.A0A084WLP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019421-RA">
        <property type="protein sequence ID" value="ASIC019421-PA"/>
        <property type="gene ID" value="ASIC019421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019421"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020788"/>
    <dbReference type="OMA" id="ADYYYET"/>
    <dbReference type="OrthoDB" id="7730203at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 5" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="438"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019421-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="574" mass="66237" checksum="E855E20B091DEB0F" modified="2014-10-29" version="1">MPRRRTTRKFFSLACYLLLLIIACIVYKNCLLNLKLHSIPPSNNGVRPTNKFNTTKAGELPGDMGHPVIMDLNDTSVQELVQEGLKTFGYNEYASDLISVRRRLPDVRAPWCRAQDNSESSLPLTSIVMVFYNEAWSVLIRSVHSILDRTPAHLIREILLVDDFSTAPYLKTRLDEYFEEYPKVRILRAPRRLGLIAAKVLGAKASSAKFITFLDAHVECTKGWLEPLLREVAANETTIAIPTIDQINPMSMELQTDFAPRVVGAFRWDLNFGWWGRAAMKKRYPNPYVPFDTPAMAGGLFTIERTFFERLGWYDEGFDIYGIENIELSMKSWMCGGRMVIVPCSRVAHVRKRSHPYLDRVNVDVVKRNSMRLAEVWMDEYRQVIFDVYGVPRYFEELFGSVDERKAIRRRAQCGTFRNYIVQSFPEMMNPLVPGAFRGEVRNAALSPNLCLTRFWANSTLSMAPCDGLKQQQSWTHNFYNELNNYSTCIEPRRLTAADHYRAEVARCHRVEKAGSQRWRYLLSSDQIRNERAGQCLAVDSSRSITIEPCNLKSSNQKWLVQFVELDDSIFRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMR7</accession>
    <name>A0A084WMR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019571-RA">
        <property type="protein sequence ID" value="ASIC019571-PA"/>
        <property type="gene ID" value="ASIC019571"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019571"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019571-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="157" mass="17157" checksum="250F70E0032B9D21" modified="2014-10-29" version="1">MFPGGAGDDSAARNVRNPSKAFPRPPPLVPVFLCWEKRKRSERNKPAVHRSVGSWESKAGGSRKLAVRLHPVTDKGALITQTGAIATSIPSSPQPPRTASCVREKIVRERREKIRGSRSDRAKTVDDCSVSSGAERRAPQHDTLRQNATVVRCALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMV2</accession>
    <name>A0A084WMV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019612</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019612-RA">
        <property type="protein sequence ID" value="ASIC019612-PA"/>
        <property type="gene ID" value="ASIC019612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019612"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014991"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="15075" checksum="F1F1A7C1D844DFC1" modified="2014-10-29" version="1">MDSGKAPGRTYVSMSMTSTNMPPPLTSIPTTSGTGGSAAGGSRIVMKPMPQQQTSQQSAVLRRRFSTSDKVTVVAMRKTAPPMITISSTAPPLASFSSGSNANIRASMPTPPTSLASSPAGSVVLSRNNKPWPSSLPPVATRSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMX3</accession>
    <name>A0A084WMX3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019636</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019636-RA">
        <property type="protein sequence ID" value="ASIC019636-PA"/>
        <property type="gene ID" value="ASIC019636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019636"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10467" checksum="F078CE88E05536C9" modified="2014-10-29" version="1">MYADIRHKTTCIRCICGRGTYCETSCGINDAANGPAPARTLPIFPTQCREGVGLISLETLADTNRKSNSSARAEGVTDGGQFGRNLPSYRCLNHCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMX5</accession>
    <name>A0A084WMX5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Rpn5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019638</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019638-RA">
        <property type="protein sequence ID" value="ASIC019638-PA"/>
        <property type="gene ID" value="ASIC019638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019638"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13328" checksum="C6A0FEB9496CD4B3" modified="2014-10-29" version="1">MTICSCNPSQQRYKHLSSAACAPTIFPQTSLIEKGANVQTMEHRLMLPFPHPPYPSSGLRYINNVVVVSISHRKQVTTTAQHLVLLARRNTRKGKRRKWQVLTLTVNFSGSQTVRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN81</accession>
    <name>A0A084WN81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">BHLH protein Hesr-1/Hey1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019759</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN81"/>
    <dbReference type="STRING" id="74873.A0A084WN81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019759-RA">
        <property type="protein sequence ID" value="ASIC019759-PA"/>
        <property type="gene ID" value="ASIC019759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019759"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014948"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="188" mass="20359" checksum="350028B81D6CE85E" modified="2014-10-29" version="1">MFSLCRTGLDDASYDPQRFAMDYHIIGFRECVAEVARYLVTIEGMDVQDPLRLRLMSHLQCFATQRELSSKANAASATSPAWSHGSTTAYPVAAAAVAYPSTHHGTSGYYHPHQNYGPHQSATAPYIPQQAGAGSANNGAPTYTELSNHNPNRGLSAYGNPQYPVSTSTHGYNTAAKPYRPWGAEMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNM3</accession>
    <name>A0A084WNM3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00019971</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525354">
        <property type="protein sequence ID" value="KFB51817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNM3"/>
    <dbReference type="STRING" id="74873.A0A084WNM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019971-RA">
        <property type="protein sequence ID" value="ASIC019971-PA"/>
        <property type="gene ID" value="ASIC019971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019971"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023256"/>
    <dbReference type="OMA" id="MCDTKDD"/>
    <dbReference type="OrthoDB" id="6275030at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0035523">
        <property type="term" value="P:protein K29-linked deubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990168">
        <property type="term" value="P:protein K33-linked deubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22767">
        <property type="entry name" value="OTU_ZRANB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.560:FF:000002">
        <property type="entry name" value="Ubiquitin thioesterase trabid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000012">
        <property type="entry name" value="ubiquitin thioesterase ZRANB1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041294">
        <property type="entry name" value="AnkUBD"/>
    </dbReference>
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        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049768">
        <property type="entry name" value="ZRANB1_OTU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF28">
        <property type="entry name" value="UBIQUITIN THIOESTERASE ZRANB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18418">
        <property type="entry name" value="AnkUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="16">
        <location>
            <begin position="541"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022687"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB51817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019971-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="787" mass="88554" checksum="088819E1265C4893" modified="2014-10-29" version="1">MSGSSSTNEQQEQESPKQQQQNQQVEDAPDQEQHCSQSKWVCEYCTYENYPLSLKCTMCKGPKPLLNEDIFRLSPTQQLSATKRSNPNLESSIVATTTTTTTTPVTEPDSNQRWPCVACTYFNLPHTKRCLQCDTIRKDDPVPGPAASSRTVGGSYKQQQQQQLQQVQQPKPSQPRGKTEYDSISEQLNAMNICRSGSSEDDPTDLLIPSGTGENVLVAKRNRNNSPSSAAYGSSSRPTTTTNVLENESPAGSVKKSSPVNTIERAGVASPPHNGGKWFCSVCTYENWPKSLKCSMCLHSREPAAGNAGGKSTPPAAKASPEHDENSINLASNIMVNNKRNQQFVTEGKNNMDVYQQERHLRLLRRQPDWDWLNACIGIAENNIGAVEAYLDCGGDPSRALTPSEVHLLSQNNCAFDVGHTLIHLAIRFHRDEMLPLLLAQISGSGPGIKRVPSYVAPDLASDIRRHFAQSLRIRKASLNCQYVNEHATFSLPADIEELPLALQEQLYEELLDKDAQKQLEMPPPALNWSLEITERLGSRLMVLWNRSAGDCLLDSVMQATWGVFDRDNTLRRALSDSLHQCGHIFYPRWKENELFQAALLQYTMADRQLEEDWSTLLSLASHPGSSLEQLHIFTLAHIMRRPIIVYGVKYVKSFRGEDIGYARFEGVYLPLLWEQSFCITSPIALGYTRGHFSALVPTEPYSRIDATRDEREDITFLPLMDCEMKLLPVHFLNKNEIGREEMLIRQWLEVCETEGGLLVAQQKLHKRPLLVAQMLEEWLNHYRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPC8</accession>
    <name>A0A084WPC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020259</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025052">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525368">
        <property type="protein sequence ID" value="KFB52072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020259-RA">
        <property type="protein sequence ID" value="ASIC020259-PA"/>
        <property type="gene ID" value="ASIC020259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020259"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8603" checksum="F90BF579F097F93A" modified="2014-10-29" version="1">MHPERLLQSIECTWFVGCCERSRSGATHSQRYGRKKNGERCAGTSHMGHIRISEQDVVATLRVENLIDGESTDIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ23</accession>
    <name>A0A084WQ23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP011637-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00020516</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525370">
        <property type="protein sequence ID" value="KFB52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ23"/>
    <dbReference type="STRING" id="74873.A0A084WQ23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020516-RA">
        <property type="protein sequence ID" value="ASIC020516-PA"/>
        <property type="gene ID" value="ASIC020516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008716"/>
    <dbReference type="OMA" id="AMQINFA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12476">
        <property type="entry name" value="RRM1_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12479">
        <property type="entry name" value="RRM2_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="216" mass="24598" checksum="BB5FFA000714D9FC" modified="2014-10-29" version="1">MDIRPSHTIYINNLNEKIKKEELKKSLYAIFSQFGQILDIVAYKTLKMRGQAFIIFKEIASATNAMRTMQGFPFYDKPMRINYSKTDSDVIAKLKGTFQERPKRVKQPKPVQAEEKKSKKQKSAGDVGATNNSATAEQPPNQILFLTNLPEETNEMMLSMLFNQFPGFKEVRLVPNRHDIAFVEFATELQSGAAREALQGFKITPTHAMKISFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQE6</accession>
    <name>A0A084WQE6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525394">
        <property type="protein sequence ID" value="KFB52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQE6"/>
    <dbReference type="STRING" id="74873.A0A084WQE6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020688-RA">
        <property type="protein sequence ID" value="ASIC020688-PA"/>
        <property type="gene ID" value="ASIC020688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020688"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001499"/>
    <dbReference type="OMA" id="WGQEYIS"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="486" mass="55319" checksum="D22C66F36690BF8C" modified="2014-10-29" version="1">MDVNQLESLMRNLVIKETRTNSLDLLESKLADVDQEVYEVMLRSASLFQFLADASSDQFNIAARIIYDKALEFFPNGSIVVDQFIERCLTHPKNNVKQFGLRGAATMVDESVGLSLNNVQLLIQHCLPMKEVFVKTLLDMLVKTLPGVFTEVGVQEQLQKVLECNETIRCRVYEVVCTILEKRPDLLTAADPILKRALADLDTDDVLLQTSVLPILTQLLETQEGFAYVESVDLFRKVYVNFVTVEVNPYVRFVLPNALKFYANAALVQPALFLSRYPEALDFIFDKAVTGDPMLMAVAYESLGIVGKTNEGKIFLSEHQRHKMDAVLKELPNILHTTTEAFKVRFIDCLINLFSVESEPIDNRISSITQKWYETMTEREDLEMVQELFKVPFPDIKMAALRLLSVIVDYRWGQLFFQNTACFGEILLNRSLDVDVNVTQFKYDVIKRLSESTTLDSFVCDTLKQYVSEGAFYRKANVEVVIEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRV6</accession>
    <name>A0A084WRV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525408">
        <property type="protein sequence ID" value="KFB52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021229-RA">
        <property type="protein sequence ID" value="ASIC021229-PA"/>
        <property type="gene ID" value="ASIC021229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021229"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9870" checksum="03AA6AE643B8AB1F" modified="2014-10-29" version="1">MHQVCRRLDGVRFGAEDKASPSEKGYKGGHVHPDSVESGKRGIRKTRLSDSSIPSSSSSPSSELLEMENNGVKGSRRDKSKGKAKGENKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS10</accession>
    <name>A0A084WS10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021297</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021297-RA">
        <property type="protein sequence ID" value="ASIC021297-PA"/>
        <property type="gene ID" value="ASIC021297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021297"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="6955" checksum="822DFA2B01A5F584" modified="2014-10-29" version="1">MKLSLPRKPINNAGDGSSPQAPCYDHLVDVKGVKSSANLPPGSLQQQLARCAPGGSTLRHRETACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS44</accession>
    <name>A0A084WS44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021338</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026324">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021338-RA">
        <property type="protein sequence ID" value="ASIC021338-PA"/>
        <property type="gene ID" value="ASIC021338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021338"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021338-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7537" checksum="38D8F10C77C69475" modified="2014-10-29" version="1">MVELQRKLHGLAFPGESATGVEKLLRTFADIHHQVEFANRKRSACLGRSTNAIKKNATEGNAFRNTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSF0</accession>
    <name>A0A084WSF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003612-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021441</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSF0"/>
    <dbReference type="STRING" id="74873.A0A084WSF0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021441-RA">
        <property type="protein sequence ID" value="ASIC021441-PA"/>
        <property type="gene ID" value="ASIC021441"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021441"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001906"/>
    <dbReference type="OMA" id="PWNKPVE"/>
    <dbReference type="OrthoDB" id="6288097at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021441-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="227" mass="24859" checksum="DC3442B1FA9D6420" modified="2014-10-29" version="1">MADLDDFFAKKDKKKGKPKKFVTAEEIAKQLDDTSKKAVESKMKMKPIEPTENSADSKQQDDEWMEVKEQKKDYTGLKLAQLTIDDESNHNDPDHLGDSNDPNYDGEGGGEGGDRDPTKPWNKLDATAAARAKVPSVVEPAAATSNVYISPALKNLRAKQKKGAPDLKSEEYFPTLGMEKPEPPKLPKKDSTFEDVKHGGRVKAVEPSSSGHVSVGNRFTSLSNDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSH0</accession>
    <name>A0A084WSH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021464</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021464-RA">
        <property type="protein sequence ID" value="ASIC021464-PA"/>
        <property type="gene ID" value="ASIC021464"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021464"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021464-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7648" checksum="77EE21EA5726B65F" modified="2014-10-29" version="1">MADQKAEITSGLSIWDWNGSCARRLAGSFRCLFVSRRPPRALALRSSVWAVPSNAFLYLLFSIPHPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTT4</accession>
    <name>A0A084WTT4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00021869</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTT4"/>
    <dbReference type="STRING" id="74873.A0A084WTT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021869-RA">
        <property type="protein sequence ID" value="ASIC021869-PA"/>
        <property type="gene ID" value="ASIC021869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021869"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021960"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25485" checksum="C022B8C4468DA83E" modified="2014-10-29" version="1">MSFNIKFATSHEDGTICHYSYFRFVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIEVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLRELRDHADQNIVIMLVGNKSDLRHLRAVPTDEAKGFAERNGLSFIETSALDSTNVETAFQNILTEIYRIVSQKQIRDPPEGSVIRPNLENIDVKPTNPTTDSVRKQCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTX0</accession>
    <name>A0A084WTX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">F-box/kelch-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021911</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021911-RA">
        <property type="protein sequence ID" value="ASIC021911-PA"/>
        <property type="gene ID" value="ASIC021911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021911"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6370" checksum="5783DB2564501873" modified="2014-10-29" version="1">MDGRYCSVLPFSLPNSPSLNQSKRHPNCRELPPIARIQATFRQVIVRKELYAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUZ1</accession>
    <name>A0A084WUZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001789-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001098</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL642304">
        <property type="protein sequence ID" value="KFB54035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WUZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001098-RA">
        <property type="protein sequence ID" value="ASIC001098-PA"/>
        <property type="gene ID" value="ASIC001098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001098"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB54035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12223" checksum="4F7D8852B16F1A64" modified="2014-10-29" version="1">MDIVNIADVLPDRIHLCNQAHLQANAPQPFAATKVLDGFISNLEPVIEGEDVKTVYDVTLNYFQDALHRHWPGDTIGILTYNMQADVEYILNRLDLEGKADAIHRVGDX</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9T4</accession>
    <name>A0A084V9T4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000046</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000233">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523861">
        <property type="protein sequence ID" value="KFB34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9T4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000046-RA">
        <property type="protein sequence ID" value="ASIC000046-PA"/>
        <property type="gene ID" value="ASIC000046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000046"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8972" checksum="E8B7B120515CED51" modified="2014-10-29" version="1">MAVKSGSTGSVPFTLHFPCRFGLCPLPKPNPSATSPSVIVPLGFHKDQGCSLLPTRQPMLALETFSSANRNRSKNKCSKRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9U3</accession>
    <name>A0A084V9U3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523869">
        <property type="protein sequence ID" value="KFB34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9U3"/>
    <dbReference type="STRING" id="74873.A0A084V9U3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000063-RA">
        <property type="protein sequence ID" value="ASIC000063-PA"/>
        <property type="gene ID" value="ASIC000063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000063"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001986"/>
    <dbReference type="OMA" id="MDHLTAG"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="445" mass="43679" checksum="C40C33E5B25CE103" modified="2014-10-29" version="1">MSQFGLSSTNSHWSYSSTGPYSPYLTSCTTPTASQFNNPALGFTCSSGEQNGGQDFASARDCVTMLPDSTAADLDQHLSTLVGATQQATSHMVQTNIMAGGGGVTVSTGNGTGNASGNGNNGNGPTQIPTHISNGLIVPRYAQTTGSNSHTDAYGLTSSQSGPRSLSDSSQAESPVQDDLLSSNTPNLGSSGPSSTTGGGGGGGANNGGGSGGASVGHHQNFSSIVMNQSNAGSNSSAVSNYVGSNGTGSCNGSPLYPVLPASLLYSQLYTAANQSVGGFSHSVNHHHHIQSPHGAAAVAAAAAVANGSSTDSASAAVASAAAAAMHAGELQSVMDHLTAGGNQAAAVAAATASHRHSHHHHHHQAGANLLGHGGQGGGGGDGNNHPDLSLIGNCGTMARGTLDEAGHRVLGGTVVGSGRLGGPPGGQGQVGQAADNGNSVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA92</accession>
    <name>A0A084VA92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000568</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01003048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524109">
        <property type="protein sequence ID" value="KFB34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000568-RA">
        <property type="protein sequence ID" value="ASIC000568-PA"/>
        <property type="gene ID" value="ASIC000568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000568"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000568-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="50" mass="5567" checksum="B73C705979BCFFD6" modified="2014-10-29" version="1">MACVEFEITERELRISSNAQLPDGLGCCAHQTDQVNPKSDDDSREQQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAD5</accession>
    <name>A0A084VAD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000615</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01003063">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524109">
        <property type="protein sequence ID" value="KFB34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000615-RA">
        <property type="protein sequence ID" value="ASIC000615-PA"/>
        <property type="gene ID" value="ASIC000615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000615"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7026" checksum="E2C9AE7FA3DD88AA" modified="2014-10-29" version="1">MPARAQNRSLAKCGKSVDDIRCNFSMRNFDQPTTKISDRVNCCDGRKSSRMSSGTKVWQGGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAK9</accession>
    <name>A0A084VAK9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00000819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ATLV01004128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAK9"/>
    <dbReference type="STRING" id="74873.A0A084VAK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000819-RA">
        <property type="protein sequence ID" value="ASIC000819-PA"/>
        <property type="gene ID" value="ASIC000819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000819"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017234"/>
    <dbReference type="OMA" id="PHNYEQI"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="158"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="281"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="485" mass="57125" checksum="A0C3A323B3BDCD6C" modified="2014-10-29" version="1">MRLSKAVSLKKLFFLVLCFAVLILLVFNLRDKDWSTKSPHVLYAREEYQQDEINVQNEPSVTTETLEVVDRAEKENEIVDYGKPRSDERSKDNTLTASDLPWYFSQGMRYPKPARRNRKTNKRVARLLPSETSRGDRISNQLMFVPPNYETIKRKGKLKTILLYNGLSPWNVKAGRDVFLSSKCPVSTCTITAQREKASTADLVLYKDHYIPPAVPRSPYQIYMMYFLECPYHTQHVKYVDAFNWTATYRKDSDIVAPYEKWEYFDPRIRQVEQDRNYALNKTRKVAWFVSNCGARNGRLQYAHELQKYIQVDIYGACGSFKCSRSTAERCFEILDRDYKFYLAFENSNCKDYITEKFFVNALTRNVLPIVMGARPEDYEASSPQKSYIHVDEFGSPRELAEYLHLLDRNDELYNSYFKWKGTGEFINTYYWCRVCAMLHDEASFRKPKWYEDINDWWRGPGVCTNGSWRNFRARNPEKPASDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB43</accession>
    <name>A0A084VB43_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Citrate (Pro-3S)-lyase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001207</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005275">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524276">
        <property type="protein sequence ID" value="KFB35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001207-RA">
        <property type="protein sequence ID" value="ASIC001207-PA"/>
        <property type="gene ID" value="ASIC001207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001207"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001207-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7266" checksum="A76F1D2A7A48E72C" modified="2014-10-29" version="1">MGHTAACGCVRLLLTTACSRQTIGRARHGTDHPLSALVERELNPAEAYDIARNHGLMRPRANTRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBB7</accession>
    <name>A0A084VBB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007828-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00001455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01006318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524352">
        <property type="protein sequence ID" value="KFB35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBB7"/>
    <dbReference type="STRING" id="74873.A0A084VBB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001455-RA">
        <property type="protein sequence ID" value="ASIC001455-PA"/>
        <property type="gene ID" value="ASIC001455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001455"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010729"/>
    <dbReference type="OMA" id="DRYLAWY"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000059">
        <property type="entry name" value="Metallophosphoesterase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="58"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="375" mass="44017" checksum="F16B0E4062245698" modified="2014-10-29" version="1">MAKNWLARMKKKFLRLHPAWRVYVILLVLLVLYNEVLIYVLQKFKWSNIYCKESDCVRILLVADPQILGKTNNRQFYAGLANYDSDRYLAWYYEQAVEHVQPDVIIFLGDLMDEGTDSTEVHFEEYYTRFGAIFPTHPTARTIYIPGDNDIGGDGRQPLNPSAKRRFRQYFSERPAWVINNNLTIYNINRITLEMTLKDPRMVDSTGADVSDRYLRIFVSHMPVLDTPSTFTSTAIRNLKPNVIFSAHLHVSQYARIHRSRVKMVHYRPLSQDKRTAYKVHSFDLSYHQDTQELLEIIVPTCSYRMSVPDIGYGYAVIDGTTLKYTVLWTTRRFYQLISYLVTFVITVGLCLVFGLYKFMREHCTCRPKYTRLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC89</accession>
    <name>A0A084VC89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005607-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524589">
        <property type="protein sequence ID" value="KFB35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC89"/>
    <dbReference type="STRING" id="74873.A0A084VC89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002426-RA">
        <property type="protein sequence ID" value="ASIC002426-PA"/>
        <property type="gene ID" value="ASIC002426"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002426"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024463"/>
    <dbReference type="OrthoDB" id="8020139at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002426-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="22778" checksum="5CB651FA5B0C96BC" modified="2014-10-29" version="1">MSGQGAPSPAGRASLPLMRPTNQSLSGHQQSGPAMANQAALSATTTTTTTTTTLSGGVQMRTAASGIAKTSRLGLVRPSSGYFSYSTHRKHPDSDNESVNSLSSSSASSRGSLYRVDSQSIANNVQQPHLPVASATRTNSIEDVSGAAGAGGGGVSMLTKLNGTSHESQTTIGGPVSLQPTTGLKQPTAIAGTGAAKPSGLRPPSAIRPPSVRSGLPRPTSYIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCA5</accession>
    <name>A0A084VCA5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005620-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002443</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524589">
        <property type="protein sequence ID" value="KFB35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCA5"/>
    <dbReference type="STRING" id="74873.A0A084VCA5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002443-RA">
        <property type="protein sequence ID" value="ASIC002443-PA"/>
        <property type="gene ID" value="ASIC002443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002443"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022213"/>
    <dbReference type="OrthoDB" id="7724017at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783318" evidence="8">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14817" checksum="792BDFEE287BE0CC" modified="2014-10-29" version="1">MKLVWVLYGFFLICAPFLSAKPLQDGELWKQNIWVCANFLSDHLWLWNGSTRSSLYAQERHRIKRQFSLNLGATHEDGYGTDVNAEAIASLWKSTSGNTKLDGSATYTQHFGGMAGDGKPRISGLLSFSHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDX7</accession>
    <name>A0A084VDX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524732">
        <property type="protein sequence ID" value="KFB36171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003239-RA">
        <property type="protein sequence ID" value="ASIC003239-PA"/>
        <property type="gene ID" value="ASIC003239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003239"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003239-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="101" mass="11109" checksum="FE9703E784BF219D" modified="2014-10-29" version="1">MKGLYGRASDKLLPLPGLPPPHPWANDLLRTQLPFEGLVGSFSFTPSPPDPRLPKVNGSKGTEQNDGKKLILLRWFANTHESGCMVEAFKYTSATKENTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEP6</accession>
    <name>A0A084VEP6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">GTPase Der</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003477</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003477-RA">
        <property type="protein sequence ID" value="ASIC003477-PA"/>
        <property type="gene ID" value="ASIC003477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003477"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10376" checksum="9D11519AF356B6DB" modified="2014-10-29" version="1">MGFPQSNVLAAESTLIEHDNTHNFGSFVSEPSGIRERGRGEESLARAEADHPSIHSALLSLERAAVCLLCGAKRLSILDDELFDEAGTAGSIFAIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEX8</accession>
    <name>A0A084VEX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003676</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524784">
        <property type="protein sequence ID" value="KFB36522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003676-RA">
        <property type="protein sequence ID" value="ASIC003676-PA"/>
        <property type="gene ID" value="ASIC003676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003676"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6154" checksum="4123EF865284448C" modified="2014-10-29" version="1">MHPPTECIALQHGAVAPEELWCARYGSRCNGRRASRIAYRLLRRSDGSGGPCLAGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF90</accession>
    <name>A0A084VF90_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00003688</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Promotes neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes and thus regulates SCF-type complex activity. Function promotes cell proliferation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF90"/>
    <dbReference type="STRING" id="74873.A0A084VF90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003688-RA">
        <property type="protein sequence ID" value="ASIC003688-PA"/>
        <property type="gene ID" value="ASIC003688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003688"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016282"/>
    <dbReference type="OMA" id="LTCFRTP"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="136"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00059219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="354" mass="38815" checksum="8B725ECAE98BFD45" modified="2014-10-29" version="1">MGSCLTCFRTPPNANVATPGGPVTSAAGAGVVHDPAMTYTEMEQVAHETDDLLPVSPLGHHMGLSERCSGGSFKKPGSGGMMNGNISCSMVGSGGGLIGGSGGAIGGGLTVESTNNNGMGSKEWIGGTVVANQTLLSDNELNKLFESYKDAQEDAILSEGIERLCGDLGYKPDDFAILVLAWRLDASQMCQFTKAEFIQGLQRMNAASIEDIRTRLQQIVERLRTDSTEDFKALYRFTFRFGLEPGHRILSLDMAISLWRLVFTVHTPDILQRWLDFLEQHQNIRGVPKDTWNMFLNFVETCDIEHYDDTEAWPSLFDDFVEYEQERTGQQKTKDDDSGGEPPPPLSHNEHNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGR4</accession>
    <name>A0A084VGR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002950-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013065">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524837">
        <property type="protein sequence ID" value="KFB37158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VGR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004365-RA">
        <property type="protein sequence ID" value="ASIC004365-PA"/>
        <property type="gene ID" value="ASIC004365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004365"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009660"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="25271" checksum="04D707FCA2F8D5EE" modified="2014-10-29" version="1">MADKSCFEQQHASGAYAKRLKRVLEQREQERLGQSQQDSTHPIASSSQEATPVLADSDEPEPIFLSDERLPSDCDDEEEEEDGAYDKYAMFDSMTAKECFRVMAILKEVEQDTMEMILAILRKKAPQFGMPKDPRTLVKTNKKATGIREVEGGKLWYNGLRHCLNIEFGKKDMSSVPELNLNFGYDGIPISXXXXXXXCYAASQAFGETWQPVFGADFKSTVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH45</accession>
    <name>A0A084VH45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00004506</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524841">
        <property type="protein sequence ID" value="KFB37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH45"/>
    <dbReference type="STRING" id="74873.A0A084VH45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004506-RA">
        <property type="protein sequence ID" value="ASIC004506-PA"/>
        <property type="gene ID" value="ASIC004506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004506"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004579"/>
    <dbReference type="OrthoDB" id="6118826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="24994" checksum="105ADBEDC91E6471" modified="2014-10-29" version="1">MYKNILPNLDKKERNGSRKWTLQCQNDTRSKLEGLRNQLVSMINRVQQQQVTQTKTYQETSQTELKNIAENKKVLDLLANSIHSLNNHAEKSSKILTDHFVTPVRSCRQVANVSGKYVFRWLEHSKPLEVYCEQEKQGGGWIVIQNRIGNSVDFHRNWTEYRNGFGNVGGDFWLGLEYVHQMTMNYWSRFRISTETTDMLSTTSSKSDVNARTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHN8</accession>
    <name>A0A084VHN8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A2M_recep domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHN8"/>
    <dbReference type="STRING" id="74873.A0A084VHN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004703-RA">
        <property type="protein sequence ID" value="ASIC004703-PA"/>
        <property type="gene ID" value="ASIC004703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004703"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002069"/>
    <dbReference type="OMA" id="ATSTEWM"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="3">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="16215" checksum="95E6AC087209C5F8" modified="2014-10-29" version="1">MEYEYLVDLRNYKRQFDLSLEKLAPRSNDELKLKVCVRYRPELTNARSNMALVEVNLPSGYVADNNPISMTTGDSSIEHVATSFGATTVIVYYGSVGSEPNCFVVTAYKRSRVSLKLPAYVLVQEFYEPTKTAIEAYNIEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHP4</accession>
    <name>A0A084VHP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Thioester-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00004709</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHP4"/>
    <dbReference type="STRING" id="74873.A0A084VHP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004709-RA">
        <property type="protein sequence ID" value="ASIC004709-PA"/>
        <property type="gene ID" value="ASIC004709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004709"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="3">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004709-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="19035" checksum="1DBC118200E9FB73" modified="2014-10-29" version="1">MQTASKYISEVNVTMLTQAFEWLASQQQRTGQFDENDAIVENDTPNGLPNGIALTSFVLISFMENENAYNAHSRVVARGLQYVAKQMDNVTDPYDRSIATYAMMLSTEYPNEGLLKRLFEKSTTSKNGSERYWVTDWRAIQEYEVDERSVCDICDGDDCPDECLPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIE7</accession>
    <name>A0A084VIE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP011680-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005054</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIE7"/>
    <dbReference type="STRING" id="74873.A0A084VIE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005054-RA">
        <property type="protein sequence ID" value="ASIC005054-PA"/>
        <property type="gene ID" value="ASIC005054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005054"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010884"/>
    <dbReference type="OMA" id="TIVTWWL"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001053">
        <property type="entry name" value="Sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF96">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005054-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="509" mass="55205" checksum="55C01D231F41ED8C" modified="2014-10-29" version="1">MADEGTTTMAALKQTLLSLSVSLSYYCIGLVRGYSAPAVPSMHETAPGLLPSKNIASWVSSIPPFGAFFGSLVAFPLMHRIGRKYTVLIASPLWAIAWVLIATATDWRVLFVARMLSGFGAGLSLPAAQVYVSECSDPKIRGVIGSLPALAMSFGILVMYIMGKFFDWRLLAWICCGMACCLFLAVACFPQSPVWLKTRKQYEKAHVSAKWLHLQGFSVDPKAASGSVAPNPTGQRNEKCPAEAIPPKPFSKEALLRREIMIPLGIGLVLLLIQQVSGIDAVVFFTVEIFRAAGSSMDGHVATIIVGTVQVLSNIAALFVVDRAGRKPLLIMSGLIMCLAMASMGAAFHLNSIGNTSFGYLPIVSLIVFMIGFSIGFGSIPFLLMGELFPTAQRSLLSSLAGSFNLAMMFTVIKTYHPLEDLITASGTFLMYSVLCALGVVFVITCVPETKGRELESIQKLFERKPRQQHEMLESGKGASHDNPVFTATDEIVRHQQNPSEKRSYDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIK6</accession>
    <name>A0A084VIK6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP012037-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00004966</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIK6"/>
    <dbReference type="STRING" id="74873.A0A084VIK6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004966-RA">
        <property type="protein sequence ID" value="ASIC004966-PA"/>
        <property type="gene ID" value="ASIC004966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004966"/>
    <dbReference type="OrthoDB" id="7741088at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="247" mass="27434" checksum="D1CDBF1A4BF31FC0" modified="2014-10-29" version="1">MGTQNLTLVLPPVSWCSPAEYTLFVNAYDVSKDKSGKLLADVEPSFVHEVIPHEKYSETSLVHDIALLRLNESVPVGSKSLPQPVCVPMDPVNDEVASVGHALRCFGWGYNAEGMLDLLQKLPLCYLRLTLYFALFWSTGVLSTTKLWVTLQRISLEDCLERFSNMPSRQPNIADVSERNICTVTISGHDAYAGYSGGPLMYHKGGRWFLIGVISYGVGAISNKFPVVSTNVQQYTDWILSKINLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJU4</accession>
    <name>A0A084VJU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP010327-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00005574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013882">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJU4"/>
    <dbReference type="STRING" id="74873.A0A084VJU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005574-RA">
        <property type="protein sequence ID" value="ASIC005574-PA"/>
        <property type="gene ID" value="ASIC005574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005574"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006293"/>
    <dbReference type="OMA" id="WHQATLT"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000500">
        <property type="entry name" value="serine/threonine-protein kinase SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="589" mass="66247" checksum="2D7AB7D8EF8DDF66" modified="2014-10-29" version="1">MASTKKSSGNIHKIREFELDKVVLSDEFDILQIVGEGWFGKILLVEHRATDTEMVLKLLPKPFVSLTDFYKEFHFSLLLGQHKNIVTTYDVAFETAGFYVFTQEYAPLGDLTSNVSDSGIGELHTKRVARQLASAIDYIHQKELIHRDIKLDNVLVFRSDFARIKLCDFGESRKLGEEVLRRNEWLPYSPPEVLLVKTDDKYKTDTAHDVWQFGIVCFVCLTGCLPWQKASADDPRFNRYQQWHQATLTFPMKRCPKLFKLLSARACKLFKKFLDPRSDRRLKTLSDLQKYLDDRWLAKSAEKEMAENEPDELCPSMYSFHSSVEEKNKLLGTLAQCGIETTVDRAAKKNRIRDWIQSSVIAEEEEEDDSGTATPTSNVSRTAVPGHVSSVAALERAEKKINSTVKEASQKHIDPRTGNIQIGPSEMGSVNAKDGNNNSTPNINGHPASSTNTGKHSLLRATQGLVKVAFNSAAAVTVPEVTRNGSFNKRGTVKDSGYGSSNGGTKTVTPSSRKISRSPTLPKRSTFIRSESNPYEEPESADDRDSQSLEFDELETDRGSNGFLNTPAEKRVPEKKPESAYDKIFFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX3</accession>
    <name>A0A084VJX3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013910">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005588-RA">
        <property type="protein sequence ID" value="ASIC005588-PA"/>
        <property type="gene ID" value="ASIC005588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005588"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="269" mass="28613" checksum="E13F8163041F95CC" modified="2014-10-29" version="1">MRDLPKNTPHVVKKASQIFLSSDRLNSNRPSTNEVFDGETSASADPGTSSSIHGRTPLFVSSSVIPKIQDSPISSNNNSAKIHNTGTIQMHRVSLEESNEASPHSISLASGTALQHDTATDDEEILEFISNEINVSDEQTPSSSPSSSSDSESESSESRGSSDGKDEIITSAQQRSDRVIEEPCSTRRKTTIHQGGVAINTPVPFGAIGPSSTNRASSYTGNVAGGSTLRDEKSRIPRLSKAVSGTSSQGKERWGSCANVPGRRKHHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK82</accession>
    <name>A0A084VK82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00005730</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014131">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524944">
        <property type="protein sequence ID" value="KFB38376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK82"/>
    <dbReference type="STRING" id="74873.A0A084VK82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005730-RA">
        <property type="protein sequence ID" value="ASIC005730-PA"/>
        <property type="gene ID" value="ASIC005730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005730"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007807"/>
    <dbReference type="OMA" id="DECTHEK"/>
    <dbReference type="OrthoDB" id="7758549at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB38376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="689" mass="79729" checksum="CC7B9A132EAE5C82" modified="2014-10-29" version="1">MDEQMENICDASYPIDPMLRRYRDQFCRTCLKHCPDGSGIPVDTQIQDTTLLDMLIQLTQFEAEHNDAFPVILCLECKSKLQQAFQIRQEFIAQSEQLVQLVAEEKIMEYFNIDIVKPDETIEANVDEYACYIDEKEGSSDFPTNLLIADGEPSYVGQEPVDGTLNQVAEDLPLEMSDLKDHSCYTKALNQYHGLGIEDDARQDNFIVDSLVENEPTYTCSSSAAELLSEDNDEQSKDWESYLQHYEQEKLAKRKLKAETRRATKSKREKPAKTKTQMLEEEAWKNFPVTTCYVCDLDHDTLTERDLHMQVHIPMLPYQCDECTHEKQKADTKPQTETTEMVEPVILKTLTRLNIHLRMHRLPHKCESCYKRFGTVARFKKHVATEHDCEPNGLTCEYCGKLYSHLNAFRKHVATHRNELSGRLKCSFCNRTFGVKSSLQRHEASHKGEKKYKCMFCDKSFSTSYNRLNHHRIHTGERPHKCLECGRTFSQSTSLKLHLQKHLPPKARTAKPFPVQRAGNGGCCPYPGCDYTAVSYTAMFTHKRTKHLPPSFHCEVCGKSFAFEKSLREHMRLHTGEKPHTCKLCDQSYRRLSSYHRHLKTHWTNGSYTCEICQKSFKLPEYLKQHTLTHSSERKYCCDLCGTSYKSKGDLKKHTQQKHSQRSTELIVSPEEVYEEEKFVITVQTGVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK84</accession>
    <name>A0A084VK84_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005732</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524944">
        <property type="protein sequence ID" value="KFB38378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK84"/>
    <dbReference type="STRING" id="74873.A0A084VK84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005732-RA">
        <property type="protein sequence ID" value="ASIC005732-PA"/>
        <property type="gene ID" value="ASIC005732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005732"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007807"/>
    <dbReference type="OMA" id="THYWSSH"/>
    <dbReference type="OrthoDB" id="7758549at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF159">
        <property type="entry name" value="GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KFB38378.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="546" mass="63869" checksum="EFDF776EECC38121" modified="2014-10-29" version="1">MDHFREGTVQLADAVEFLPNDTASNDGSYHEDDEVDQEDESVDSNDPSKSDTQGEDADGIVKLEDDAEEILPESENTYEKSRRSEVQPLAIRTLDKKRKKRISWKHFSLSSEEARKRKAEILRERARAYSLACNRKRYRLEAEAQNSFPLTTCYICDKKHDTLMERDFHLRDHIPMLPYHCKECNEGYEAADTAEKDKPAVLKTTNQLNAHFRMHSMPYKCDKCYRRFCTDLKLKTHYWSSHGIAEKGLTCEYCGKQYFQRTMFNRHVAYHRNELSGQFKCSMCDRALGSNSSLRRHEASHKGEKKYKCLYCEKLFSTSYNRLTHQRVVHTGERPHKCNECGRSFVDNSRLKLHQETHYAEGRSPKERIRKSALLPEDKQSCPYPGCDFTAETYRTMYMHKRTKHMTMHKCEVCKKEFPFAANLREHMTVHTGEKPYRCEVCDRSFRHSAMYRRHLLTHSDTGSSHSCELCKKSFKMARYLQAHMLTHSSERNFICGICGNTYKTKGELKKHTQSKHANEFNGDYVILSGDSTVVENQWVKTYVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKU0</accession>
    <name>A0A084VKU0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005966</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524955">
        <property type="protein sequence ID" value="KFB38584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKU0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005966-RA">
        <property type="protein sequence ID" value="ASIC005966-PA"/>
        <property type="gene ID" value="ASIC005966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005966"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9390" checksum="988B690B46FB4F0F" modified="2014-10-29" version="1">MQRRLPRDYMVPVVLLAIVFLWTSRDGRTLAKQGRSNKPELDDFLQQRLTSGRYFPKRVVEGSFKQTKRGEAIDNLTTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKV9</accession>
    <name>A0A084VKV9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP010553-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005980</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM half pint family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKV9"/>
    <dbReference type="STRING" id="74873.A0A084VKV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005980-RA">
        <property type="protein sequence ID" value="ASIC005980-PA"/>
        <property type="gene ID" value="ASIC005980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005980"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011576"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015750"/>
    <dbReference type="OMA" id="VHTHKGY"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12370">
        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12371">
        <property type="entry name" value="RRM2_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12648">
        <property type="entry name" value="RRM3_UHM_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000136">
        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006532">
        <property type="entry name" value="PUF60-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034211">
        <property type="entry name" value="PUF60_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034212">
        <property type="entry name" value="PUF60_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01645">
        <property type="entry name" value="half-pint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="559"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="661" mass="71459" checksum="1D2B3A9045768466" modified="2014-10-29" version="1">MAAASHCFNAGPKYCGSNEYNSGSNNNNSEASPAREEYRKEPECSPPPAKVSKRDKERERDRERRERREREREREEREREPKILPYIAQPVYDLRQTGDVAFGPGTRSALLGILGGALPRLTSEQHELVTRAKKYAMEQSIKMVLMKQTLAHQQQQLASQRTQVQRQQALALMCRVYVGSISFELKEDTIRAAFLPFGPIKSINMSWDPITQKHKGFAFVEYEIPEGAQLALEQMNGAMLGGRNIKVGRPSNMPQAQQVIDEIQEEAKSYNRIYIASIHPDLTEDDIKSVFEAFGPIVTCKMSQGNAVHTHKGYGFIEYQTNQSAIEAIASMNLFDLGGQLLRVGRSITPPNALMGPAANSAMPTAAAVAAAAATAKIQAMDAVATNAVLGLSATTPTLKVGLGGLPLNPAITTAAGAGLVAHAQLAAATQAAAVINNQPGLLVPPVSSVGLAPSLLVNPVLGAAAKPLPTVLSQANPAAVAAAAAAAAAAAAAAAAAPNATAEDVYKKAQEKQQEELQKKLLEEGEPQTLQQQESMSIKGQSARHLVMQRLMRPSKSKVVILRNMVGPEDVDETLQEEIQDECSKYGAVDRVIIYKERQSEGTFAEDDNTDMIVKIFVEFSQATEADRARESLNGRYFGGRLVKAESYDQALFDHGDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL71</accession>
    <name>A0A084VL71_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AGAP008193-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00006117</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VL71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006117-RA">
        <property type="protein sequence ID" value="ASIC006117-PA"/>
        <property type="gene ID" value="ASIC006117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006117"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009580"/>
    <dbReference type="OMA" id="PGTGNQF"/>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00255">
        <property type="entry name" value="nidG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783751" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="17">
        <location>
            <begin position="84"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="16">
        <location>
            <begin position="301"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="734"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="777"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="857"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="900"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="943"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1073"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143033" checksum="48A529D3A3F0D215" modified="2014-10-29" version="1">MVSYKSGLFLLIGVLLPLHAVAVDSRDLYSYMNEAVEVLPRGDEEFRYMDLGMPIFFYNEKYDRVYMVGFLNLPFPLGNPAIAPFYSNVDTTLPNDTATIVYFTSRDPNLLEKTARLVRENFANQHDFQAQQVFVATWEHVGHFNMKNDVQNSFQVAIIQGAQATFVQFLYPENGINWIQGETGETGLPDVRAQAGFTGDDDVTFSLPGSGTDNVRHLYISSNINQPGLWLYRVGPLAPQENVEQPRHKLDQQSSEPRSCADGGRYKCHSAATCVNSQWGFCCQCKSGYYGNGFSCVKNDIPLRVAGKVGGTVNGETVDTQLQSYIVMADGRTYTAISPLEEQLGTELQLVQTLGATIAWLFAKPLGETINGYQLTGGKFNHTSTLQFETGEMFYITQRYSGLNVWDQLALDVEMSGTLPKVPALEKLQLDDYTVGLRAAGNGRLQATSTHSFRVASEGRNISCILYQDITYDVCRGNEEANARREQGTLKITRVNLGYEPREKAVRMGMLSKTVVGDQFNPCDEANCGDNTVCVPKPDDTYDCNCKNGFMYVHYGKTERVHCVDIDECSGTNICDENAQCYNEPGGYSCRCNPGFEGNGYQCDRVSATDAGEPTSSSYTVSTPASRENEVESYSERYYCDRCAEFADCIDGQCQCRSGYVGDPTTYCQALCDAESVWNGESCVKQLYAEEEEIAPFCTILGCTCPTGYTLIEYAFNQICRRVAIDPEEAPHPDLPSCDVENNCSPNANCEWRDNVYAYECICNPGFDGNGYTCVEKEVSCLDDEEICDIHASCNYILNLKMSICVCNKGYEGDGRTCHLAPECSVHDDCGMNSECQDGLCVCQEGYERDLSDFCVRAGSCGGAYCAENAVCRLDGVQKIPYCHCPDGFIGDGVSQCKSVPPPCNVRNNCGLHATCAPSYRDSSVFQCVCNSGFFGDGFVCTPERNCVNIPSLCDPNARCDSTTTGYQCICKDGFIGNGTVCNTAHRLDDGFLLISQGVANIRVPLNGGFGFPVTMAFMSIGLDRDCVEGRIYWSDIAAQQILSAKYDGTDQKPFITKDIISPEGVAVDWISRRLYWADSEKDTIEVASLENPEVRTVLVNKYLVNPRGIAIDPHQSKLYWSDWNREAPKIEWANLDGTERQLLVGSPQVALPNSIQVSMASGELCFADAGTKKIECVDTYSKRLRTIASNLTYPFGLAVTDDLFYWTDWITKKIESIDQYGVRQKAINSPVFGNHKMYGMTAVTDKCPLFHSPCVINNGECPENTICLINPRAPSGRSCKCTRNCNDVILDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLI3</accession>
    <name>A0A084VLI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP000615-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00006312</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014499">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLI3"/>
    <dbReference type="STRING" id="74873.A0A084VLI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006312-RA">
        <property type="protein sequence ID" value="ASIC006312-PA"/>
        <property type="gene ID" value="ASIC006312"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006312"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020731"/>
    <dbReference type="OMA" id="LLGHWMD"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783786" evidence="4">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006312-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="805" mass="89309" checksum="014023D1630D907B" modified="2014-10-29" version="1">MRLSWKCFSLLCLFVASAARADLDAALDGSKKQAQSKKDGESEKYQERAEHTPTYQRKSAEGLIEIPEKDDVSYKHSNSDHDAVTEKIDFDTIKLVQITDFSKEKDSKKVPDVLYDILENQKRMIQKIVNEIGEIESNQEQEQTGDTELGGRGEEATEAYQIYERAMGVLNKTKVDRILGHKLMVEAAAKGNSLARSHVAWAHLLGNPVPLDIEAAKQTFLELAEEGLPDAQMGLGFMYAAGIGFNVSQAKALVYYTMAATGENSWAQMALGYRYWAGVGVPNSCEMALDYYRKVATKVASQVTFSGGSAVHRIRLLDEVDNSGPSSGILDNDLIDYYQLLADKGDVQAQVGLGQLYYQGGRGIPLDHQRALQYFSQAANAGNAVAMAFLGKIYLEGSDNIKADNETAFKFFKKAADLGNPVGQSGLGIMYLHGKGVRKDTLKALKYFAKAADQGWVDGQLQLGNMYYSGIGVQRDFKLAIKYFSLASQSGHVLAFYNLGQMHAIGLGMIRSCPTAVELFKNVAERGKWADRLMSGYQDYRSYRFEESFMQYALLSEMGYEVAQSNAGFLLDREEVNLFKNRGEELVRALQYWGRAAAQGYSAAQVKLGDYHYYGMGTLIDYEMAASHYRHVKHALRMASEQQNNAQAMFNLGYMHEQGLGMKKDIHLAKRCYDLAADSSVDAKVPVTLALIKLQLLFKLESLKETPLKIIFNLDENIASNWDLYLITVITILFGAALYFRRPVAPAPAPPGGHPRQPEMNNDPVIAADYNEDAPEMNAAENPPAPRANGNNEQNAEPTLNDNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLX8</accession>
    <name>A0A084VLX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP009111-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006460</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLX8"/>
    <dbReference type="STRING" id="74873.A0A084VLX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006460-RA">
        <property type="protein sequence ID" value="ASIC006460-PA"/>
        <property type="gene ID" value="ASIC006460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006460"/>
    <dbReference type="OrthoDB" id="8011344at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006460-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="22838" checksum="6D85F43B9CC864A5" modified="2014-10-29" version="1">MPLIGTCNVVLRNAHNQSAVQEDFVIPSEMKYGFPVNHFNFYNLEIRTNLLHYTVYFAAIILLAVIGTMVLCTKDVMDFSFIRYTSMMFTLTAMQIRELHGTITQSQLNTIIKTHQATLKCFDHLQKALNLASLEVLRALQELSWYKQSPAVQKGILFMIQSAQRPIVLTAAKLIPINIAQFSEIVKKSYSVYLVLKDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMT5</accession>
    <name>A0A084VMT5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00006631</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="ATLV01014625">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMT5"/>
    <dbReference type="STRING" id="74873.A0A084VMT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006631-RA">
        <property type="protein sequence ID" value="ASIC006631-PA"/>
        <property type="gene ID" value="ASIC006631"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006631"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001930"/>
    <dbReference type="OMA" id="FSWMTPC"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0835">Urea cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB39279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006631-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="429" mass="46520" checksum="B2E9185CFE0C62AA" modified="2014-10-29" version="1">MLPRGAEVKVIAASFGQGDKKSTGFQPPFKGKVIASSLSHPESRDDYEDQAAASRLEGSLQMLPRLAVVRVVRQLTKQSGGVLGTSTAGYATSAQGDGRDLSLLKAKKINYERIGIVGVPFDKGQRKKGVGLGPKAIREAGLIDHIQEISPTLNIKDYGDIQYEALNFNGRKVGNMKKLEHVASCNRNLSHQVTEVLDDDRLCITLGGDHAIAVGSIDGHLHHSKDVAVIWVDAHADLNTNSTSPSGNIHGMPVALLAKELCDYWPYIPGMDWQEPIISIKNLAYIGLRSVDPYERAIIEKFGINAFGMREVEKYGIKEVMRMALARIDPEGKRSLHVSYDIDSLDVLEAPSTGTSVRGGLTLREGIFIMEEAYGTGRLAAVDLVEVNPAIGTPEDVRRTVEAAVHLLVAACGHSRKGDIADTLDLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMU2</accession>
    <name>A0A084VMU2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006639</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMU2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006639-RA">
        <property type="protein sequence ID" value="ASIC006639-PA"/>
        <property type="gene ID" value="ASIC006639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006639"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8285" checksum="2FF5079DAA18998F" modified="2014-10-29" version="1">MTMLAVKNFFLPERKAPPEAPKFSRMPEAFLRSIRRRSLRIKRPKTVIVEREKRKSDGLHMVCEPLFSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR46</accession>
    <name>A0A084VR46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cellobiose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007946</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007946-RA">
        <property type="protein sequence ID" value="ASIC007946-PA"/>
        <property type="gene ID" value="ASIC007946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007946"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="21613" checksum="6196E009DC8005CF" modified="2014-10-29" version="1">MALDKRKTALPAGMKNFRGRSDLNFADLRHESFFARRRPGPPKLPAGLPVCRRRRKLVSQRCLSRLSTIRGGKRMPVGLLRHEGVKTCPRPERDSPISTPGGRDERGNVFAMGDRSVTSGLGRILNRWEFDTAIPTCNELCCGRGSISIRSYLPGTRDAGGRSLHASTWSHLERIQRLQLQQLTLDEPSTAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRU8</accession>
    <name>A0A084VRU8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001877-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008311</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VRU8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008311-RA">
        <property type="protein sequence ID" value="ASIC008311-PA"/>
        <property type="gene ID" value="ASIC008311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008311"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008624"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008311-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1376" mass="142037" checksum="560A05E6887E33E5" modified="2014-10-29" version="1">MNSAENEPQEIDGTTREGQKQQVVVASSDLFHHQLPRKQEAAGVDSSWATQNVNDVGGRGESGGTYQRPDPSEAGNETELLNHHVAASSRTIYLTADGNGEVHLGTTGEAEVHAEEDEDSRRRRKNFTMRDPQESHHRLPLGEVESGDDSDCVVVAAPSERKVEPLKINLARDREPIRTIIKLTPGTGGSVLDSSSCSQQLSPTIREVPGSPKITIKPPKPPPPSTMEGPGGGGAPSSSSSSSLVGGANQNSNSVLSLPSTSTTALPNSSSIPKLTIKPVINPAEELLTVEAPAEQMQIIPKLLIKGSSLDASIHGVTEPHIVPKLTIRGVNNHNHHFHHHNHQHHPPESQSQSTGDSTGTVAAGASASGSSTTPSTPLVPKLTIKMDNHHPHHHPHVQQSQQHNNLRMKDVADAGGGGSGNRVESPIPKLHIKAILPEAGGSCSTQSPPSVGGSGSNILATASGSGNSLTSSEGVKLTIKPLPEPKLPKLTIKTTGLGTIAETSDASMVSSTSCSFSPKMMPAGNSHDQQHHHHHHHHHQQHNQIQLLAVAQQQPASPSDQHSNISSSSIPKITIKPIPAKLGLQQQQQSPTGSAAGNAASMGGADLPQTIPKLTIKPIPPPSSTKQSTGEDSNSSSETSINSLESSPVSSSCSSSSVATSAVITTSPSALRMTIKVSPQQDASSAGTTSGSTVTKLNIKPILPPPFPNPTGDANEPGADEVSPPSEGEVDPSAAPIVIPKVTIKTLANPRSQETEILSTPKVTLKPIPKPTGHELQLPGSPAIGQSVVEKHSPQAQAAANSIGHAAAAAAALTSNNSPTAGMTASDGGGSMDSPRIILKINKGSSSTTTTSLEQQQQQPDGMDTTESSSISHPPPTGGSSILANELKRPAGNAAANSIAPFSSSSSSASSTTVSISTSSSSAGSDPASPSSSAGGGDQGEPGSPEAKKSKLELVAAGVARVAREQQQKFIPHQLSEHNAALRQSLLENHQQQQQQLLQKAQQQQTALVGTGGQPPVADVIVIDDDSKSENESSERGESEKPPVDSSHVPKKLPDLNLISQDPASLRQQPIFAFMSNNEATTIEVVKPRRTRGTSRGAGGGRQSRRGAGGGRGAVAKQQPVVTDEAPRLKLPEVLVNHDDNDEGSSSDCMIVDDPSAATTTVSSVPTVRSGLSLESLLLGGGGIKQPVLYNTTHAGGGSNELEKNGTASNSSIGSVSSSIGSTPIPASPATATPGIRMSTRRGAGQLLKEVLANKHHDRDSGVDDEARTDGESGPHHGGPTPSKRPRGRPKKQSVDLTMETNGNGGSSSSLEGNGAGGGGIPDSNMMMALAMMSGGAGGAEGVTFLRPDGPGMLGTQQLLEGIMPLPITPVRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRZ8</accession>
    <name>A0A084VRZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001916-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRZ8"/>
    <dbReference type="STRING" id="74873.A0A084VRZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008169-RA">
        <property type="protein sequence ID" value="ASIC008169-PA"/>
        <property type="gene ID" value="ASIC008169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008169"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010649"/>
    <dbReference type="OMA" id="MLRVWQD"/>
    <dbReference type="OrthoDB" id="26518at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008169-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1238" mass="131883" checksum="BB49E7F78EC48452" modified="2014-10-29" version="1">MLENATKTTVEQISNEITAIDNRIKKIKKQIELPKTEEDIKFQMEEFLSAAEQDVVMLQRALKQLEAMRVQLSEFFCEDVGTFKMEECFKIFHNFSEKFQHAVKDNEKRRVQEEQALIRRKQREETLRRRQSNQPGTPVSDSEGSLLLDASQYDLRYSPAMSRRRLGSFNSNGDALLMRDECASPDITPNGSLRRRRSRVLSEEDEGNLMDFLRSSGHESSNRERKSAAYGSLDRSWARRARSGSGSKKRPDLLNVQFGADRERPSSPSPLTESKPLAVEEHKPRISREWRQKIESWLQANEQDERQNDDYKKKLKRVTANRRSYETDNESDRGSKLDPLPEEKPPTVTSPEPANVPKIITPGCQQVSTADGGGGSPSPPDQQLFGGQMTYKRVYPNWRPATSVEQTDVVGTIEALTGAVSPDADKSTWRKSLLNTVSSTESEDSAALAAGQRYRRQRSREGANPSSNLQSILEEDKRKNIIQALGERPPSDRLQIYIRRGSDNPPLPDSTTTSPTSGKTTTDATGGVDESNKQSIYIRQLGNEKQSIYIRPPNEGTNVATPSTISSSTASTTSGGSEMIVGAGDAGSSTSPPSSAVAPPPRRARRAHHVYDESTNNKIEIDSDNIETPPSIRRNVNVGASNGGGATASSGGSSCRRLHHQSSRGGESSVGDSKDSLLLAGDSGKGSSATETVGAEVLGDGQFDRFSSARRTRRFKRPIDLGAGAGSGNETTTTATTTTASPSPESLPDSAAQSPLLVPSGTATRTTQVSGTRATTIGTTKDSAKEQEQRLKRWQDKLKSSSTTTSSPTTVTSSPSTTHGRDSPRTHAEAVLNRASKVGRTISRISQEDVREAIRSLKSPTPERTWSPTKEHGLVNAKGAPATHELNDEGFEETQSLVSDTPSQGKDSVSSCNDYGSDTKSKRPTVTSASGKPLATSVDVVPTGGSLQRNKLAPSGGHRSSPSMASLLMVKNGQQSASSLERSRSLRAAPSSPATTSVTSSPGSKNLLPRRTTSMRRTAPSGEGGSLGSLGNHRLAAPALSQDVERSNSRTSLRSSRSSLSSAVSTNTVRKVPPPLRTPAKSSPLSNSGSALHTTTLSANSSPSKRPLGTATASNIGHRGAPASRSSSSGSSIGPTAVARKPPTKSSLGASASFKENHHSPAPSSGRIPSGSKSTSSGSLAGSGTGGGVSPTPVSGRSSAVGQQSSAASSAAAAVAAARRTGGFMRPTTSSATKVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSE3</accession>
    <name>A0A084VSE3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002413-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSE3"/>
    <dbReference type="STRING" id="74873.A0A084VSE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008415-RA">
        <property type="protein sequence ID" value="ASIC008415-PA"/>
        <property type="gene ID" value="ASIC008415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008415"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016197"/>
    <dbReference type="OMA" id="KXSESEA"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5MP1/2-like HEAT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008415-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="243" mass="27841" checksum="7BFA639E2B4EB64E" modified="2014-10-29" version="1">MSQKAERPVLSGQRIKTRKRDEREKNDPTGFRDAVIAGLEAAEDLEQISKYLDSAGNKLDYRRYGEVLFDILIAGGLLVPGGSISQDGEKPRTDRCVFAASEDMESMRNHEQIFMRLMRRYKYLEKMFEEEMKKILIFIKGFTPLERIKLARMTALWMANGSIPPQVLHVLNNEHLTKDGLALEFLLEVFTVFKQEKGGNAPLVAALRKGGLDTRLMEFLPVNKRNEDYLKTVLLEKDLADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTL2</accession>
    <name>A0A084VTL2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA helicase aquarius</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Intron-binding protein of 160 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00008901</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Within the spliceosome, interacts with SNRPA1, SF3B1, SF3B3, SF3A1 and SF3A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01016361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTL2"/>
    <dbReference type="STRING" id="74873.A0A084VTL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008901-RA">
        <property type="protein sequence ID" value="ASIC008901-PA"/>
        <property type="gene ID" value="ASIC008901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008901"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015232"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000396">
        <property type="entry name" value="RNA helicase aquarius"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="22">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="23">
        <location>
            <begin position="199"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="20">
        <location>
            <begin position="508"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="21">
        <location>
            <begin position="833"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1113"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1113"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB41306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008901-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1235" mass="143035" checksum="E83442387C83D8BC" modified="2014-10-29" version="1">MKQLLDMLKFYARFEINDETGDPLTDHDMTQLHYAKIKSLQKAAFAKFPNLRQFALSNVANVDTRASLEKHFGALDCGSLREIACYLNLVPEELQPPFEWHRVDEKFLRELLISRHERRVSQLESLNEMPLYPTEDIIWNENVVPTEFYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVSRMLPWQSEDGDVVFGGWARMALPIQSFAVVEVSKPHIGEKKPSRVRADVSVTLNVRKEVQEEWENLRKHDVCFLITVRPTRPIGTKYDYREHFVPQVGLVHVRGCEIEGMLDANGRVIEDGLEQRPQLSGEQRTFRVWLDSNQYRVDMDATLQQEGDDGGEDVYEGFNIIMRRKPKENNFKAVLETIRHLMNTECVVPPWLHDILLGYGDPGAAHYSRMSDQARVLDFNDTFLDYEHVAGSFPGYEMIPVGVDPTSQEGTLLKPPFRLTYEDVPEEDDSDDDEEKEGKEEKELPKRIRVESYRIPRRGPYKYNEPKKNAIRFTPTQIEAIRAGMQPGLTLVVGPPGTGKTDVAVQIISNLYHNHPQQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEESLETEKDYSRYGRVNYVLSKRIDLLGQVGRLQESLGVTGDVAYTCETAGHFYLYHVVARWEKFLNDFERPTGEEEEDAARARFEEQFPFTRFFKDAPQPLFGGQTYEDNMEIAHSCFRYISHLFTELEEFRAFELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRKELVTMGFKYDNILMEEAAQILEIETFIPLLLQNPLDGYNRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRLVRLGVPTIDLDGQGRARSSICELYKWRYSTLGDLAHVHQWPEYCRANAGFAFEYQLINVEDFNGVGESEPNPYFYQNLAEAEYVVAVFMYMRLLGYPAEKISILTTYNGQKHLIRDVIESRCATNPMFGKPHKVTTVDKYQGQQNDYILLSLVRTKTIGHIRDVRRLVVAMSRARLGLYIFGRVALFKNCVELQPAFRLLMNRPLQLQLYAKETYPCERRLSGDEATKSDQEPETIKDMTEMAQFVYQFYMRKVNVIRDEMEKMKELYEKQRQEQQEKMDEQVKQSDAEALEAEKRKQQLAAAAKKDFAPTPIRNELAEPEPVVSERPRRGKKRPVEGEEQEQEQTVVEQQGEEAVAEDNEKPAEDQEVEAMETGTEEEKKSEESTTVEAEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUK3</accession>
    <name>A0A084VUK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003758-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009272</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525127">
        <property type="protein sequence ID" value="KFB41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUK3"/>
    <dbReference type="STRING" id="74873.A0A084VUK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009272-RA">
        <property type="protein sequence ID" value="ASIC009272-PA"/>
        <property type="gene ID" value="ASIC009272"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009272"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003507"/>
    <dbReference type="OMA" id="GQNFMSA"/>
    <dbReference type="OrthoDB" id="190089at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF19">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009272-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="411" mass="46126" checksum="52A5406E260A996E" modified="2014-10-29" version="1">MAEPVPELTWISTDYFVRVLEAYLHADVTVQRYELAAGCAGGQNFMSAIVRATVHYTLGSAPEATRPDSVSLILKTKLSNAELAQDADLLNVFGIEKCVYGPVLKGVRELLTSFGDCTQFAPRFIYEDDRALVLEDLAVKGFRQPDRTARLDLAHLRVIVKKLAKFHAATAVLERKNRELFSPLANSMFTSEDNPVHLFYANAIQHCIEQTERVPQLAQYSRFLREFLQSAIERESKSYERSTAGFNVLNHGDMWLNNLLWKYDSEGSVEDVIMVDYQESFFGSPAFDLTHLLHSSANTAIQRAGFDELLQLYTDELRDALRQFKYDGPLPDLAYMQAEVTAKRDHALIVTTCIVPPLITKETELATPENMLGDDEQAVRARQLIFSNPAFIEVLEVLLPRLAIVDGAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUQ4</accession>
    <name>A0A084VUQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP010476-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUQ4"/>
    <dbReference type="STRING" id="74873.A0A084VUQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009328-RA">
        <property type="protein sequence ID" value="ASIC009328-PA"/>
        <property type="gene ID" value="ASIC009328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009328"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003049"/>
    <dbReference type="OMA" id="YLYCSII"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009328-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="14130" checksum="61826E319222801D" modified="2014-10-29" version="1">MSSEESTEQQAAIAEVPEDSTTEEVQQEQQQSVSELEKQEEEKMKAKYGSNASMGGPRGLGGHSAFLQKRLQKGQKYFDSGDYQMAKQKGGGVKQVFANKVPTGEAIPTPETVPVRKTSIIQTCNKFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUY8</accession>
    <name>A0A084VUY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00009438</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525156">
        <property type="protein sequence ID" value="KFB41782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VUY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009438-RA">
        <property type="protein sequence ID" value="ASIC009438-PA"/>
        <property type="gene ID" value="ASIC009438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009438"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016301"/>
    <dbReference type="OMA" id="TKVGCGA"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784067" evidence="3">
        <location>
            <begin position="37"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB41782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="39016" checksum="36FBA33F2C00CA52" modified="2014-10-29" version="1">MKSYSTTSTDTRWRSGSGSLVLLAVTLCVTPVSVWAAADSDVNYCDQSLCRSNYTHIGCNATESFGVLCPAATVQLVNMDQPMKDRILKLHNSLRSELASGKMNGFAEAQRMAVLEWDDELAKLAEYNARTCQYLHDECRSTKRYRNAGQNIGRKSRAGNVTVDLEQAVTDLTNKWWQEYVETNQTVMDNYRPVGEGVDVGHFARMASDRVTKVGCGATRYYNVARKRSNVYYVCNYSHSPELGQPVYRKGPQCSKCGADPGAKCSSTYAGCARASARRSIRNSRSEAPXXXXXXXSPARKNLTCVRSRRGSCGKLSWLALVSGWILQQLFPAARINSGCEQPFWNGGPLDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV23</accession>
    <name>A0A084VV23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009644</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009644-RA">
        <property type="protein sequence ID" value="ASIC009644-PA"/>
        <property type="gene ID" value="ASIC009644"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009644"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009644-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6025" checksum="D89EA73D5B84FF13" modified="2014-10-29" version="1">MVTTTRAHNHTCVHIAPRPHVMLTRTPNGYVGARMASRMAGGAFDTGPVDCGGWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVZ4</accession>
    <name>A0A084VVZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP003631-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009801</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVZ4"/>
    <dbReference type="STRING" id="74873.A0A084VVZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009801-RA">
        <property type="protein sequence ID" value="ASIC009801-PA"/>
        <property type="gene ID" value="ASIC009801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007957"/>
    <dbReference type="OMA" id="GWERDFL"/>
    <dbReference type="OrthoDB" id="10049706at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF24">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="294" mass="33500" checksum="4FE6C863B44559FC" modified="2014-10-29" version="1">MYVVSSVKHTISTWSPYGRKNVTHESVLPRNVRYDRFVPPDRKLNLRQRAKVKPENSSHSYIFSLALADLLVILICVPLASMIYTLESWPWGATLCRVSESAKDISIGVSVFTLTALSADRYCAIVNPLRKLQTRPLTVVVAFLIWLLAIICAIPSAVMSDVMTANLSNKEIEYCTPFGPRATDSDYSKYKTILNSIIYYFLPLSIIGLLYALMARRLHTSAREMPGENAGPQSRSQARARRHVARMVITFVVAFIVCFLPYHVFALWFHLNPHALDDYDDWWHILRITGFCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW97</accession>
    <name>A0A084VW97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cell wall biosynthesis glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009918</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525172">
        <property type="protein sequence ID" value="KFB42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009918-RA">
        <property type="protein sequence ID" value="ASIC009918-PA"/>
        <property type="gene ID" value="ASIC009918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009918"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9332" checksum="2E70C4A0A26B5AEA" modified="2014-10-29" version="1">MHTLLHHDLTEWVELNGQHRSPGRPNSTDCTRSRTIAENLSLSGADRGLESTRRLFVMTMESLYVTIKNIQPRDAIREEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWG6</accession>
    <name>A0A084VWG6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Sulfakinin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009995</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gastrin/cholecystokinin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017584">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWG6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009995-RA">
        <property type="protein sequence ID" value="ASIC009995-PA"/>
        <property type="gene ID" value="ASIC009995"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009995"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007003"/>
    <dbReference type="OMA" id="YRARSKM"/>
    <dbReference type="OrthoDB" id="6360815at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013152">
        <property type="entry name" value="Gastrin/cholecystokinin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013259">
        <property type="entry name" value="Sulfakinin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08257">
        <property type="entry name" value="Sulfakinin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00259">
        <property type="entry name" value="GASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759905" evidence="7">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009995-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="187" mass="19838" checksum="E052EEA4C7AA1C26" modified="2014-10-29" version="1">MARITLAFLVSLVAYLAYYALTSDAQAVGSLVRSPGPDGLSGAGSPSSAVSSLDAIGNGRPDKLPSARVRRPIGYRERAAARLFGNSFPGNQAYQAYRRIPPGAPDQASVADDGLPIGADSSGKPEPRVYFHAGYRGDAGGSFLDDNDDGGDGDIVKRFDDYGHMRFGKRGGEGDQFDDYGHMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWR7</accession>
    <name>A0A084VWR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">AGAP010089-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00010114</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWR7"/>
    <dbReference type="STRING" id="74873.A0A084VWR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010114-RA">
        <property type="protein sequence ID" value="ASIC010114-PA"/>
        <property type="gene ID" value="ASIC010114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010114"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012691"/>
    <dbReference type="OMA" id="MLACKSV"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="75"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010114-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="387" mass="43765" checksum="A677733D422EB284" modified="2014-10-29" version="1">MFALNETTEAAEGAMLMPMARTAIGEMPKLLGWNLPADEQHLVHDHWRGFPAPPYYMHLMLAMIYFVLMNTSIIGNGIVLWIFGTSKSLRNGSNMFIINLAIFDLLMMLEMPMFLVNSFSERLVGYGIGCSVYAAFGSLSGIGGAISNAVIAFDRYRTISNPLDGRLSRVQAGLLICLTWLWATPFTVLPLFEIWGRYIPEGYLTTCSFDYLTDDQDTRVFVGSIFTWAYVIPMLTICYFYARLFGHVRQHEQMLKAQARKMNVESLTANRNEKAQAVEMRIAKAAFTIFFLFVCAWTPYAIVAMIGAFGDRTLLTPFVTMVPALCCKIVSCLDPWVYAISHPKYRQELERRLPWMGIKEADDSVSTTDSKQTVVSDQQQQQQQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY27</accession>
    <name>A0A084VY27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Dmoj\GI11955-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010625</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY27"/>
    <dbReference type="STRING" id="74873.A0A084VY27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010625-RA">
        <property type="protein sequence ID" value="ASIC010625-PA"/>
        <property type="gene ID" value="ASIC010625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010625"/>
    <dbReference type="OMA" id="CAETNFP"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010625-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="7342" checksum="0DDEF775279F325D" modified="2014-10-29" version="1">MFCASAPGKDSCTSDSGGPAVHDGQLIGLVSHGAGCAETNFPGVYTLVSAVRDWIDGIITGNTGDNPTDGQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYI4</accession>
    <name>A0A084VYI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">WUSCHEL-related homeobox 8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010702</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYI4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010702-RA">
        <property type="protein sequence ID" value="ASIC010702-PA"/>
        <property type="gene ID" value="ASIC010702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010702"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14850" checksum="B04DA5432E8FE2BA" modified="2014-10-29" version="1">MEPEEGVGVCVSVSGGRVGGDYLRDLRKDMPAKHTDQWMAVVAMVCGLLTDCFKCASTQRRRPGPKLGNCVRGCGPETREETELKSDILIGRPTHFHQLRFLPVHRETFVQFRAHGMGGEKKNLWVQEGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYR7</accession>
    <name>A0A084VYR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018420">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525233">
        <property type="protein sequence ID" value="KFB43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010879-RA">
        <property type="protein sequence ID" value="ASIC010879-PA"/>
        <property type="gene ID" value="ASIC010879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010879"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015184"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="17678" checksum="7701DE97C279CFD3" modified="2014-10-29" version="1">MLVDPLNPLLAWFVRWGLINPFFIQNILVDPLNLLLVRFVCWGLINPFFIQNILVDPLNPLLVRFVCWGLINPFFIQKILVDPLYLLLVLFVCWGLINPFFSEKILVDPLYLLLVLFVCWRLVIALLQHLFDPTNKIKSFSESSGSVCLILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYU6</accession>
    <name>A0A084VYU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">PDZ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010911</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018475">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525234">
        <property type="protein sequence ID" value="KFB43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010911-RA">
        <property type="protein sequence ID" value="ASIC010911-PA"/>
        <property type="gene ID" value="ASIC010911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010911"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="176" mass="19957" checksum="EB63B51D2BAB4F93" modified="2014-10-29" version="1">MGRRKVFPLEQSDGVPLLCPSGRTKQNEPNPETTTGRKDHPHKMQNYPAPDSGKKLQPREERKLTKTLIEIRAHRGDRVSVGKVTMTTTSLPASERPFNRHKSPEDRRSLGGKTYNHRHSERTSTMARIRSAPEDTHEPREQSVRRTPFPTHPIGTQEKSHTPGKTTHTADQMTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYY0</accession>
    <name>A0A084VYY0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010948</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525236">
        <property type="protein sequence ID" value="KFB43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010948-RA">
        <property type="protein sequence ID" value="ASIC010948-PA"/>
        <property type="gene ID" value="ASIC010948"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010948"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="50" mass="5594" checksum="88A311C29EEBF4C8" modified="2014-10-29" version="1">MHPETRVSHDVPSEMESLLRNSTSCVGFAGSLVLFVPEIDYIKSKETPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZW9</accession>
    <name>A0A084VZW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003730-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011319</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019012">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011319-RA">
        <property type="protein sequence ID" value="ASIC011319-PA"/>
        <property type="gene ID" value="ASIC011319"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011319"/>
    <dbReference type="OrthoDB" id="10545987at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784304" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011319-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6318" checksum="B159A676F584E768" modified="2014-10-29" version="1">MAIAKMTRSFALFFRLTVVLLLLGCASSGAEAYRLGVGRADCTGPPVEIGFVSIWCGVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZY9</accession>
    <name>A0A084VZY9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP012866-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZY9"/>
    <dbReference type="STRING" id="74873.A0A084VZY9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011344-RA">
        <property type="protein sequence ID" value="ASIC011344-PA"/>
        <property type="gene ID" value="ASIC011344"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011344"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022460"/>
    <dbReference type="OMA" id="DYDASPQ"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784358" evidence="3">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011344-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="18354" checksum="142233D763A73F49" modified="2014-10-29" version="1">MAFKFAVFAAIVAVANAVAIGYPSPLGAYHAPLGAAYHAPLGAYPAVAKVAAPLAYPAVAKVATADYDPNPQYSYSYSVADAVTGDNKQQQESRSGDVVTGSYALVEPDGTRRVVEYTADPVNGFNAVVHREPLAVKAVAPVAKIAAPYAPYGYPAYGKVAAPIAPYGYPAYGKAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W137</accession>
    <name>A0A084W137_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c1, heme protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Complex III subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Complex III subunit IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome b-c1 complex subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00011757</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="21">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W137"/>
    <dbReference type="STRING" id="74873.A0A084W137"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011757-RA">
        <property type="protein sequence ID" value="ASIC011757-PA"/>
        <property type="gene ID" value="ASIC011757"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011757"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020347"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="23">
        <location>
            <begin position="147"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB43931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011757-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="365" mass="39554" checksum="BB3327FDF7AB9593" modified="2014-10-29" version="1">MAAFVGRICGSGLLSPKSGATLQKVGNNGPLLGNVNSISILRKRTRVSQVSSAVLKRCWSDPCKTTPPWSVDPSAEYGESDPTVQNFSTTRAWTKSQKVATAAGVLVGGAGALLYALEQSVAASGTEVHPPALPWNHKGVLDSLDHASVRRGYEVYKQVCAACHSMRFIAYRNLVGVSHTEAEAKAEAEEIQVRDGPDEAGNYFMRPGKLSDYFPSPYPNEEAARAANNGAYPPDLSYIALARHGGEDYLFALLTGYCDPPAGVVLREGQYYNPYFPGGAISMAQALYNEAAEYSDGTPPTASQLAKDVSTFLVWAAEPYHDERKRMGIKSVGIIMILGALSYYIKRHKWAALKTRKISFHPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1I6</accession>
    <name>A0A084W1I6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011914</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019349">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1I6"/>
    <dbReference type="STRING" id="74873.A0A084W1I6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011914-RA">
        <property type="protein sequence ID" value="ASIC011914-PA"/>
        <property type="gene ID" value="ASIC011914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011914"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011200"/>
    <dbReference type="OMA" id="IFHRKLG"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000009">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="184"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011914-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="33811" checksum="4EF5526FFFE23A50" modified="2014-10-29" version="1">MSSGLLKVDHPSNNGSGLVPGRLSLSSDNLTTTGSSSNRLGNGGERGGSLTPNILPSMDRLSAPIITRRKFSFPANLHSTALLGFPEIGRADGFSGSGSSLSAAGTALSARRRLSNVSDVVTRKLSSTIGWKQPVLPSQDIITQGKCLCGQYIRCRLKRSGVFNRKLGLQRIRSIVGTPSIHVVREVGEELERMYPRIYNGIARQLTRFGRGELKTPETAPVLLSAIARDLFKADITWGKVVSLFAIAGGLSVDCVRQGHPDYLPKLVEGVADVIEDELVSWISENGGWIGLANKVRPPQEEITFTGRNPNGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1U9</accession>
    <name>A0A084W1U9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA repair protein complementing XP-G cells</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00012042</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019462">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W1U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012042-RA">
        <property type="protein sequence ID" value="ASIC012042-PA"/>
        <property type="gene ID" value="ASIC012042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012042"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000044">
        <property type="entry name" value="DNA repair endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="944"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="449"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="731"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="796"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1201"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1342"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="631"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1244"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1370"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1397" mass="153992" checksum="75D95A57438BB4D7" modified="2014-10-29" version="1">MGVLGLWKLIEQAGKPVPLDTLENKVLAVDISIWLHQVIKGFQDSKGSALPNAHVLGLFHRLCKLMYYRIKPIFVFDGGVPVLKKQTIAKRHQSKNNYQNEADRIQQLLLETLAKEKVVQQALGSATNILISPSKKAITSGAAGSSKQAEREEEPDAMFKLPPLKAPEEPIDLDRSDSSMDEKASRNYYHLNLNAIDVTSVYFKNLPADVRHEILNDIKETRKQSSWGRLHELPVESNSFSSFQMNRLLKRRQVQVELEEAEKEMGGKCLSLAELESLLNEEGVETSSSRAAQQIASDENTRFLLVRDVQKAIEKAKAREEEQKLAPKPPKLAKLAREDGAGTSRAGALEEDDKEMDEELQLAIKMSLMQDENPHAVIELDDEDIRMSRTQKQVLGNAAQSLARGFMLEYGGLTSEEFNELLHQTQDVDGGDINDSMSQMFVHNGASIVEGSSMSSCEKPTTSKPLEGDDKSLGKESVEEDTESDSDFIDVPEDDLNDSLPGVSLPLNSTNHFKPHFNPIVDFTIDDLKKLSNVPTTQKKKVVEVFIKEEDMGVCDKDDIFADIFVKKETHSEVEKEGGQEKSTSEQHPMTSIPITGGKGSLSDTTVAENDHKDTPIDLLTTKPPTVGIKIKNVDDINAQLKEELENLKKGPPVIDLGVVSSQPPIVVAEREKASADLKRLSETLKQQLEELKASANAVSLDDIKLDAIPIDKEKLHKADDDDDSDATVIYDSEIVQGVKTPSKETSPKKEGGIEKDSLPPSKKADEGSANVPVPVIEILDSPAKKGTLEHLVIARTPGKDSKTDQPDEIVPHVTKPFFVNKTPPSSGKKHASAKDGAAVNDSVPAEKSSSGVAKELFPSIDSVPVPSTSKQSAPPDPKPIDAEHLITEMADTLKESRTPLELKQMALDLAQTERELEREKNKQNRLGVSITEQMRNDCMELLSLFGVPYIVAPMEAEAQCAFLNQIEMTDGTITDDSDIWLFGGQKVYKNFFNQQKLVLEFTIEAIEKMFHMDRKKLIQLALLVGSDYTTGIHGIGAVTALEILASFPPTPEQAGETSEMMSLLSGLRRFRDWWQHGRNGATVGARMALKSKLKNIDISEGFPSTGVVEAYLRPTVDCSEEQFTWGYPDADRLRDYARQKFGWSQSKTNDILLPVLKRLDERKSQASIKDFFKVQSAVAQSRLKVSKRVQYAVDTMAGKVDPAEDKPKQKKTSSPRKAKQAAGPATRRKSKASSSTTGSVETIDLDTIDEGDEDGAEEKEKNDDDDFVVPKATARKRGAKGKTNTATANNSKPKRGGKKSDPKSTDATTSNDVQGPAATPGHSLANIGGIIANINQQSADSLLEEPATRGRKKRLENKIPDFNPPIPQRVKDEQEMAERKQRAAELLKKVNARKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W239</accession>
    <name>A0A084W239_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012191</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019492">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525273">
        <property type="protein sequence ID" value="KFB44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W239"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012191-RA">
        <property type="protein sequence ID" value="ASIC012191-PA"/>
        <property type="gene ID" value="ASIC012191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012191"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012191-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8557" checksum="3EB410C83615F9B3" modified="2014-10-29" version="1">MSSHITVTVCDGDGATLSVSGKVRQGKIRKATTAVSSGAKKRSVTDRRIDRRIGKLGHHRDNNRSTVNGGTRFGSVPPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2E5</accession>
    <name>A0A084W2E5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Type 11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012333</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2E5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012333-RA">
        <property type="protein sequence ID" value="ASIC012333-PA"/>
        <property type="gene ID" value="ASIC012333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012333"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012333-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13777" checksum="798CE0A57A9AB2AD" modified="2014-10-29" version="1">MSEPRLVVVKYSQECPCWQPVHVKSLLDESHMAYRECGLPNVSWQHQDYNLPLYTNFFDILLRLKCSQQDISGGPLPLLCPVGRVLTVDVENHILNKVVSPKLKRLLRSSNLARLYSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3I5</accession>
    <name>A0A084W3I5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012703</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3I5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012703-RA">
        <property type="protein sequence ID" value="ASIC012703-PA"/>
        <property type="gene ID" value="ASIC012703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012703"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="145" mass="16036" checksum="21F359518B2A9589" modified="2014-10-29" version="1">MQISVRRCSAGHYRSLIGTVKTVPRERVRSTYNAGRPKSESNANIITQTRGQNRCTPPRVIPMRCELPPPQALTLFTIVALSKHGFPVALATRSDLRGINRHGVLLLERNPVQSSHEVRRTIIAMVDARRVINGGANGPYVSINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4F4</accession>
    <name>A0A084W4F4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GLE1 RNA export mediator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00013017</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525298">
        <property type="protein sequence ID" value="KFB45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4F4"/>
    <dbReference type="STRING" id="74873.A0A084W4F4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013017-RA">
        <property type="protein sequence ID" value="ASIC013017-PA"/>
        <property type="gene ID" value="ASIC013017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013017"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011741"/>
    <dbReference type="OMA" id="ELLMAHF"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000001">
        <property type="entry name" value="Nucleoporin GLE1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="152"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="695" mass="77871" checksum="46636CDB7E2BB214" modified="2014-10-29" version="1">MDSKKEFNVEDLLTGFETLKISALRNAAKLSPLIKECTLGPGCVDLSQKTRTQPGTGVTAETTADAERAKENDLNGSNEGTPPRSGRSVKTVEKKTPTTSPFAGCIQSESTSCAAVTSKLHQEELERQRQASVQKVLAERQSKIQLADKQREAQLRQSLQEAKLAVARKMQESEQRILNAVREQEQMAQEAGTRRLAEIEQENRRQSDIQAQLKRRQEELKRKAQLIDAIRQHNAQFRTGTETFTKALTAIGVQHASKFNNQKKSIRSLQKDFEQLLQTINANHEVTQPEIDQAAEYCKQLDQVNVEVSEIILQIEASQKQQQEQLQQQQLEQQQKQEQAAQEAATQQPETAAKAPDSADGAVSAPVPLPSTLPAADDSEPIFWPVSPECLQFYNEIKSFYEQHQAAVKQLMDDPSMKTYRFNCQKAINVPVNAISAVSREHLIDKYERLAALLSGQNVKVGDATVSINGHPLGRTYCTMLMAKKFVGQGDQSISSNASAAFPIATVIVGLWQQFPDFGRFFLAYLHRECPYLVPYYLPQHEGQSQEDYLKSLGYRFAEGGQMEKQDQYLKRMAGLARLYAAVIVTIPRIDPSKPHPHGLENGWRWLTNILNRYPKADICATLIVEFLQTTGAFLSMTYRSQFTKLIQLLQGDYLSALSRIDQGGPKARLEGLIAQVVRDGKFDTPEGMLSLQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5I7</accession>
    <name>A0A084W5I7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010239-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5I7"/>
    <dbReference type="STRING" id="74873.A0A084W5I7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013413-RA">
        <property type="protein sequence ID" value="ASIC013413-PA"/>
        <property type="gene ID" value="ASIC013413"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013413"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007265"/>
    <dbReference type="OMA" id="FFFQDGE"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000033">
        <property type="entry name" value="dnaJ homolog subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000026">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013413-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="346" mass="39347" checksum="665945BEFF20903D" modified="2014-10-29" version="1">MGKDYYKTLGIPRGSTDEDVKKAYRKLALKYHPDKNKSPGAEEKFKEVAEAYEVLSDKKKREMYDKYGEEGLKGRASNGTTNSSQNFSYEFHGDPRATFAQFFGSNNPFGSFFDMHNDSLFNSSIFNDDDFFTPFSGLGNRHGLGGAFRSHSFNVHSPLKKEKIQDPPIEHDLYVTLEEIYHGCVKKMKISRRVMQQDGTPKKEDKCVSISIKPGWKSGTKVTFQKEGDQTKGKIPADIVFIIRDKPHVWFRREGSDLRYTARLTLKQALCGVIFEVPTMTGEKLRISTKQEIIKPNTVKRIQGYGLPFPKEPSRKGDLLVAFDIKFPDKLSSSEKEVLNDMLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5J8</accession>
    <name>A0A084W5J8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00013427</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5J8"/>
    <dbReference type="STRING" id="74873.A0A084W5J8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013427-RA">
        <property type="protein sequence ID" value="ASIC013427-PA"/>
        <property type="gene ID" value="ASIC013427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013427"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013980"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="18">
        <location>
            <begin position="344"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="20">
        <location>
            <begin position="626"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="19">
        <location>
            <begin position="818"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="846"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139356" checksum="8DC502591D942E19" modified="2014-10-29" version="1">MLTNFETKSARVKGLSFHPKRPWILASLHSGVIQLWDYRISTLIEKFDEHDGPVRGIAFHNQQPLFVSGGDDFKIKVWNYKQRRCIFTLLGHLDYVRTTVFHHEYPWILSASDDQTIRIWNWQSRSCICVLTGHNHYVMCAQFHPSDEDIIVSASLDQTVRIWDISGLRKKNVAPGPTGLDDHMKNPGATDLFGQADAVVKHVLEGHDRGVNWASFHPSMPLIVSGADDRQVKLWRMNEYKAWEVDTCRGHYYNVSCVLFHPRADLIISNSEDRSIRVWDMTKRQCIHTFRRENERFWILAAHPNLNLFAAGHDSGTIVFKLERERPAYAVYGNCLYYVKERFLRELDFNTNTDSVVMTIRGGGKTPVYSMSYNPALNAVLLCTRTSNLENSTYDLYSIPQKDSGSQNKETDSKRSSGVTAVWVARNRFAVLDRANQLVIKNFKNEVTKKIQTPTCDEIFYAGTGMLLLREPEHVTLFDVQQLRSLAQVKIAKCKYVVWSTDMSHVALLAKHTLNICNRRLDLLCSIHESARIKSGAWDESGVFIYTTSNHIKYAIINGDHGIIRTLDLPIYITRVKNSQVFCLDRECRTRLLTIDTTEYKFKLALINRKYEEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEVALEAAKAMDDKQCWERLAQSALMQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVSILKNCKQTSLAYLTAKTHGLDEDAAQLAEEFEAEGKDLPEVNGNAMFLRPPVPIQQAESNWPLLTVSKGFFEGTMMSRGATTVHQALAPTETVAESAAEEDGWGVDDDLQDGDRFEDAKEDDEGKMEAGGEGAGWDVDEELELPEELMSKLTASNAAGTKNYFAAPPKGHPPSHFWAINSQLVADHVRAGSFESACRLLNDQVGVVNFGPYKDLFLESYVASKTSYSSLPHVASLTAHPNRNWKELNPKNGHPTLAFKLNDLVQNLQNCYQLTTTGKFGEAIEKLQNIILCIPLLVVESRQEIAEAQQLLTICREYVVGLQMETVRKTLPKATLDEQKRICELAAYFTHVNLQPVHQILTLRTALNLFFKLKNYKTAASFARRLLELGPRPEVAQQARKILQACEMNEADEHPLHYDEHNPFTLCAVTYRPIYRGKPEEKCSLCSASYQPAYKGIACVVCKVAEVGKDVIGLRISASQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5S5</accession>
    <name>A0A084W5S5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013555</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5S5"/>
    <dbReference type="STRING" id="74873.A0A084W5S5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013555-RA">
        <property type="protein sequence ID" value="ASIC013555-PA"/>
        <property type="gene ID" value="ASIC013555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013555"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019256"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="184"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="494" mass="54776" checksum="4D194B0826A9D888" modified="2014-10-29" version="1">MAAVETKPDPVEETPEGVEDKEDAADDVADENAPEGKKKKKRNRKPKKTAAEIEEAEILREAMAERQAEDKAIAAEKASKAAAETKQPADGPQPDGEEEGDDDDATAAGATGEGAKKKKKKKNKKKPAADKLVAPSVPISEQFPDGKFPEGQIMQYPDSTTAKDRFTNEEKRALDRMHMDIYNELRQAAEAHRQTRQYMQKWIKPGMTMIEICEELESTARRLIGEKGLEAGLAFPTGCSRNHCAAHYTPNAGDPTVLLYDDVTKIDFGTHIKGRIIDCAFTLSFNPKYDKLLQAVKEATEAGIREAGIDVRLCDIGAAIQEVMESYEVELDGKTYQVKSIRNLNGHSISPYRIHAGKTVPIVKGGETTRMEENEFYAIETFGSTGRGLVHDDMDTSHYMKNFDAPIVPLRLQSSKQLLGTISRNFGTLAFCKRWLDRAGATKYQMALKDLCDKGIVEAYPPLCDVKGSYTAQYEHTIMLRPTCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W671</accession>
    <name>A0A084W671_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00013664</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525306">
        <property type="protein sequence ID" value="KFB45715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W671"/>
    <dbReference type="STRING" id="74873.A0A084W671"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013664-RA">
        <property type="protein sequence ID" value="ASIC013664-PA"/>
        <property type="gene ID" value="ASIC013664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013664"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014273"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000022">
        <property type="entry name" value="AGAP010835-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB45715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="22754" checksum="4FE9767EA6618206" modified="2014-10-29" version="1">MSSDKGFELIREFERSTDPIPAFNDDGVRSVLEDITKIYQENYAHAITFNETRDRKFLPLVLYRHKLIQRQKRCVLAYLANRLFRLKALRWHVGATLPPEIKACINEPESLWFNKYSKILAEYMASIHDGYGLNLTNDIKPPKSLFIEVRCLTDYGKFELENGEIILLKKNSQHYLPKLQCEQLIRQGILQHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6B2</accession>
    <name>A0A084W6B2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013729</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020775">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6B2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013729-RA">
        <property type="protein sequence ID" value="ASIC013729-PA"/>
        <property type="gene ID" value="ASIC013729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013729"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013729-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="14128" checksum="D023A705C2E8A2F1" modified="2014-10-29" version="1">MVTPRSRRVAGVDEPGRATFAAGQERLAKHDDGDAAALMNKNDPILGGTLDNGVPDTEDISGHAVGSLALAKRVHSSAHRVRLRLQDATALCCTITLESPPVLLLTNLLDHLEFAAVETVVDETGRQELQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6S1</accession>
    <name>A0A084W6S1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013878</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525310">
        <property type="protein sequence ID" value="KFB45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6S1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013878-RA">
        <property type="protein sequence ID" value="ASIC013878-PA"/>
        <property type="gene ID" value="ASIC013878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013878"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001762"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13653" checksum="8B31607EE0DB4FA2" modified="2014-10-29" version="1">MVSLRKDFDHLMGVMGTSSTQPASNEAEKSETNETADHNAIGTKRYSLRRNAYKRVVKQKKFKIAGQDDELSDSSSEESQAPSSPEWGNSKSQLDDNEPRRRRAIRRTKTCISDDDDDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7Q6</accession>
    <name>A0A084W7Q6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Heat shock protein 70 A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014234</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7Q6"/>
    <dbReference type="STRING" id="74873.A0A084W7Q6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014234-RA">
        <property type="protein sequence ID" value="ASIC014234-PA"/>
        <property type="gene ID" value="ASIC014234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014234"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002785"/>
    <dbReference type="OMA" id="PCQSVNP"/>
    <dbReference type="OrthoDB" id="7752173at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000058">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="639" mass="70085" checksum="15250BFD58BCF159" modified="2014-10-29" version="1">MPSAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFSDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRKYDDPKIQADLKHWPFTVVNDCGKPKIQVEFKGERKTFAPEEISSMVLTKMKETAEAYLGQSVKNAVITVPAYFNDSQRQATKDAGAIAGLNVMRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRATAGDTHLGGEDFDNRMVAHFVEEFKRKFKKDLSKNARALRRLRTACERAKRTLSSSTEATIEIDALMDGIDYYTKISRARFEELCSDLFRSTLQPVEKALSDAKMDKSSIHDIVLVGGSTRIPKVQSLLQNFFCGKSLNLSINPDGAVAYGAAVQAAILSGDKDEKIQDVLLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQTQTFSTYADNQPGVSIQVFEGERAMTKDNNLLGQFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEKSTGKEKTITIKNDKGRLSQADIDRMLAEAEKFREEDEKQRERVAARNQLEAYCFNLKQSLESAGSKLSESDRKMVQDRCDETLRWIDGNTMAEKEEFEHKMQELTRACSPIMTKLHQQSGAGPAPSSCGQQAGGFGGRSGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7S0</accession>
    <name>A0A084W7S0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00014247</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="ATLV01021293">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7S0"/>
    <dbReference type="STRING" id="74873.A0A084W7S0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014247-RA">
        <property type="protein sequence ID" value="ASIC014247-PA"/>
        <property type="gene ID" value="ASIC014247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014247"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023537"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="26"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="393"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014247-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="515" mass="55992" checksum="927A02FE54F59994" modified="2014-10-29" version="1">MNPEAVSHLEHMCSLDIDATAPFVRLSGIICTIGPASVSPEMLEKMMATGMNIARLNFSHGSHEYHANTIKNIREAVENYSKKLGKPFPLAIALDTKGPEIRTGLIEGSGTGEVELKKGEKIQLTTDKEHLEKGNKDKIYVDYVNIVKVVKPGDHVFVDDGLISLVVDSITGDTLTCSVENGGMLGSRKGVNLPGVPVDLPAVSEKDKSDLVFGVEQGVDVIFASFIRNAAALKEIRGILGEKGKHIKVISKIENQQGMQNLDKIIEASDGIMVARGDLGIEIPAEKVFLAQKSMIARCNRAGKPVICATQMLESMIKKPRPTRAEISDVANAIIDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHRNLFKDLVDTTPTPLDTATSIAIAGAEASIKSRAAAIIVITTSGRSAHLISKYRPRCPIIAVTRFAQTARQCHLYRGILPVIYEQPALEDWLKDVDVRVQYGIEFGKERGFLKPGNPIVVVTGWKQGSGFTNTIRVMYVSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7X4</accession>
    <name>A0A084W7X4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP004631-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7X4"/>
    <dbReference type="STRING" id="74873.A0A084W7X4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014309-RA">
        <property type="protein sequence ID" value="ASIC014309-PA"/>
        <property type="gene ID" value="ASIC014309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014309"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014845"/>
    <dbReference type="OMA" id="THDHEGN"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF17">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13703" checksum="6FBE994448FCBBA9" modified="2014-10-29" version="1">MDVPIDTSKMSEQELQFHYFKMHDSDNNNKLDGCELIKSLIHWHEQGKAQENSGQPQHEEKIFSNDELSALIDPILNSDDHNQDGFIDYPEFVRAQHKAAQQQHQDQQQQQEQQPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAS2</accession>
    <name>A0A084WAS2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Nephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAS2"/>
    <dbReference type="STRING" id="74873.A0A084WAS2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015350-RA">
        <property type="protein sequence ID" value="ASIC015350-PA"/>
        <property type="gene ID" value="ASIC015350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015350"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012535"/>
    <dbReference type="OMA" id="AHMQPIT"/>
    <dbReference type="OrthoDB" id="6689787at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015350-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="360" mass="38610" checksum="9AF5290B293092B0" modified="2014-10-29" version="1">MEKHIPTPTGSEATVPPELSEKAELPSFVIFCIALAGLCLLIVNAGLVAWFIMKKRAKDASNTNGSKTATIEMYAPSSYNDTVTGETLSSVSEKSDAYSNDGSQPDFMPDETRKKAASTYLVDGVDLPPPMYQQDGSMPRYITNVGNGDVHCASPGPPNDGSYYNMNSERYLSYPPMDYPGVEHGTPPLPILPSMPHTESASETLRRVARTMVPPPDVTHHTLNRTHAHVSNPSGNLNGSISQAAQSTPKQPQGILKDPKRSNSSASGTSLSFALLPTQHHHPHQQQVAFPTQSPSLVYQQQQQLDHHPSGLNGFLIPTSHDAPSLGNGLLLGAYEPPSSSSLASYNVSLGYTDADGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC78</accession>
    <name>A0A084WC78_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC78"/>
    <dbReference type="STRING" id="74873.A0A084WC78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015779-RA">
        <property type="protein sequence ID" value="ASIC015779-PA"/>
        <property type="gene ID" value="ASIC015779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015779"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014773"/>
    <dbReference type="OMA" id="MERANMD"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9483" checksum="38F97AE3A94AB143" modified="2014-10-29" version="1">MADGKSEIDSDAEQNYSLNSNVDPKNMQELTIYVQNLLQNVQDKFQTMSDQIISRIDDMGTRIDDLEKSIADLMQQAGVEGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCL9</accession>
    <name>A0A084WCL9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00016015</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01022743">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525336">
        <property type="protein sequence ID" value="KFB47963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCL9"/>
    <dbReference type="STRING" id="74873.A0A084WCL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016015-RA">
        <property type="protein sequence ID" value="ASIC016015-PA"/>
        <property type="gene ID" value="ASIC016015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016015"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016742"/>
    <dbReference type="OMA" id="LYEATHP"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000502">
        <property type="entry name" value="Tyrosine-protein kinase Drl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000165">
        <property type="entry name" value="Tyrosine-protein kinase RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="17">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="258"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB47963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016015-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="526" mass="59511" checksum="D2DB54D042DECDAC" modified="2014-10-29" version="1">MANDEYKIKPTIHNRLSAEIYYVREGQVNEYALHFTVPVPVDVEEISFTWQSLAKKPLPYRINIVSPDLIALPKPSMNISWQGEIPEHIETFAIGLRCSGRESAEVDVTITVEVTLDRLTGNATELVFRRKKICLMSDHPDANQPDPYLLENASNGQNGLITLVIGGILAILFVALIILIAFCTRGSFHRKPHNAQPIRTSSFQRLQTHAPSAPSSIHSPPSIAPTIATLSRTRIYANVEPEELQRRISELTVQRCRVRLSSLLQEGTFGRVYRGSYNDSQEVLVKTVGPHASQIQVSLLLHEGMSLYGAQHPGILSVLGVSIDDHTAPFLLYLAPENSRNLKIFLQEPVARSLTTIQIVKIQLQLAQALGHLHSHGVIHKDIAARNCVIDDQLRVKLADNSLSRDLFPGDYYCLGDSENRPIKWLALESIQYKQFSESSDTWAFGVLMWELCTLARQPYAEVSRSRFEMEHYLRDGYRLSQPINCPDELFAIMAYCWTMLPMERPSFEQLQICLQDFYAQLTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD36</accession>
    <name>A0A084WD36_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010209-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00016192</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD36"/>
    <dbReference type="STRING" id="74873.A0A084WD36"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016192-RA">
        <property type="protein sequence ID" value="ASIC016192-PA"/>
        <property type="gene ID" value="ASIC016192"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016192"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002036"/>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09366">
        <property type="entry name" value="LIM1_Isl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09374">
        <property type="entry name" value="LIM2_Isl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000034">
        <property type="entry name" value="Insulin gene enhancer protein ISL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000056">
        <property type="entry name" value="insulin gene enhancer protein ISL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047244">
        <property type="entry name" value="ISL1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF8">
        <property type="entry name" value="TAILUP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016192-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="478" mass="52980" checksum="F546845C872FA04B" modified="2014-10-29" version="1">MAEIGGPLAHQLPLHNHRGGLVQPSLVMNHHLDSLDSSGCHGPNIHPKKERLSLCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDKCGSSFSKNDFVMRAKTKIYHIECFRCSACARQLIPGDEFALRDGGSLYCKEDHDHLEKTTQNGLIAGVEPNNNISGNANNNNISSTNNNNNSLSNNNHSSELGSMSGVCHTIKQHKEMPPNPPASSRRHRHLVKCFAGKYCLRTFRASGLRRKRVRPRGNPHRRTDDDNVQLRAGPIRYRSLPPATLSPAPANAAKCPVSVFILPVFLRRASPRLSFRLRPVVRSRNFHATAAAGKLPPQAFESAQPRVGFFLSFGLTKAKECRSCGEHRKTNASNRMLQPGVLILVQFEAYVLPPLRCFFAAVIAGWRLLKASRRSILEPSLVAPDQPAKSPLRRHGSTSTGYLSPAPPIIVCSPKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD89</accession>
    <name>A0A084WD89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP008003-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00016252</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WD89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016252-RA">
        <property type="protein sequence ID" value="ASIC016252-PA"/>
        <property type="gene ID" value="ASIC016252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016252"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014039"/>
    <dbReference type="OMA" id="KQMPPRI"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000247">
        <property type="entry name" value="WD repeat-containing protein 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016252-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1474" mass="164014" checksum="8C9A54A49E2B1729" modified="2014-10-29" version="1">MLNTNLVVPVVLWGPNTPTHCVSSVFLSRDQKILATGCYDGQICLWQVDPETLQMTPRCLLVGHTAPVLCLTRASIIQDNNFLVSSSENGEMCTWDLVDGKCTESIKMPQVHTNIQAYHMANCDDIRLFCNGYYAEIMVMDPFSLEVLFCLSSKVNPDWISALHVLRPSKRKDDVVLAITTTGTVKVWTLIGNENKYSEPIYENESKQIRCLNAITMNCCSQNQRTVLIVCAKYWQIYDAGDFTVLCSVISPSGERWMGGDFLSNDRVILWSDEGKGYLFRLPANSIPDNKDFHGPSVGKDSPFLYCILSQTGEKPLSCPPTMKLVTSNRGGKTQKYLLRGDSEGYVNIWAVPDISMEQIKQIQNLKQHPQTLEATICTSLLEAWNKMSPLPVGILDQLYQNSEPLIKLTASIYLPQQSRLVVGREDGSIIIVPATQTVMLHLLHGNHQKFIDWPPHQILNGHSGRVNCLLCPSLAHSRYDKSHLVSGGVDFAVCLWDLYSGALIHRFCVHAGEITQLLVPPPTCSPRILKCICSVASDHSVTLLSLQERKCVTLASRHLFPVVSIKWRPLDDFLIVGCSDGTVYVWQMETGHLDRVLHGILAEEVLNACDENTGETGSSAGSTSEMGLANPAVHFFRGLRHRNINAIRHATQRGIHQLQQLHAHNNQHGDFLMKNRSSPLIIQGLRTNPKDAESHILFFDIEGLIFELHAEEYAAMSPNTLEAEGLLIPAGADSHSSDAGKKISDFFGRVKNKAGDMEKILKEKDKHGILAKMKEGAENVQTKVQAKLESVVKNVGETGKDSSDISKKIAPRMEATHVMEVAQLLLSLIHSWGLDPHLDKVCETQLGLLRPMIPVSFGVLSKGGYMSLLLPTWQNNIVINSTPEELKTVAMTPEQFRREGLTKLFTARLHWELSTTLTSNHLLAMVAMSNTLMSMNMATFVPEQERARKLHRQSTRATWTNNEEEQEEAFTQQQAQIKQGWSLLSTHHCFLLPEKIDALDANNFKRPQVEMMARRWQHHCLEIREAAQQLLLGELGRMGKKGRKQLVESWAQYLPMYTHTEPIVQQAPGGGQSNAGSPTSSPTGQPGLEHEEESEEEEEVVRKPSSLAELKRKQTTAVVLLGVIGAEFGQDISASDGKRNNENRRKSSVVEGFGIGNNNLARSTSMALTHLLLAPPTQKLPAYTPLRRAAIDLIGRGFTVWEPYIDVSKVLLGLLEMCCDSNRLIPSLNYKLPLTPQADACRTARHALRLIATARPAAFITTMAREVARYNTLQQNAQAISVPITQSVLHRAKREILQCVEMLIDKMQTEIANLLVEVMDITLHCVDSGDLKNKGLAEVSPLMCKFNQVSHCSASRRIAVGASNGHLAIYELRQNKCQMIPAHTKPVTALAFSPDGKFLVSYSCTENRLSFWQTSAGMFGLGQSQTRCIKGYSTAPIPDVARLNPMRLAKLIWINNRTVTLMLADGSETRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDF9</accession>
    <name>A0A084WDF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005813-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDF9"/>
    <dbReference type="STRING" id="74873.A0A084WDF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016376-RA">
        <property type="protein sequence ID" value="ASIC016376-PA"/>
        <property type="gene ID" value="ASIC016376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016376"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022046"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000001">
        <property type="entry name" value="Iron-sulfur cluster assembly scaffold protein IscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016376-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16123" checksum="69F23E58741F21A3" modified="2014-10-29" version="1">MSLPRNVNTLLKITRARSVPVALYHQNVLEHYENPRNVGSMDKKDKNVGTGLVGAPACGDVMKLQIKVDENGKIVDAKFKTFGCGSAIASSSLATEWVKGKTLDQANQLKNTDIAKELSLPPVKLHCSMLAEDAIKAALEDYKKKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEF9</accession>
    <name>A0A084WEF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016591</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEF9"/>
    <dbReference type="SMR" id="A0A084WEF9"/>
    <dbReference type="STRING" id="74873.A0A084WEF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016591-RA">
        <property type="protein sequence ID" value="ASIC016591-PA"/>
        <property type="gene ID" value="ASIC016591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016591"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022445"/>
    <dbReference type="OMA" id="GHATGCE"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784748" evidence="7">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="259" mass="27643" checksum="A00F92C7E045F196" modified="2014-10-29" version="1">MKLAITVVALLVASLALVRAGVPGVRVVNGETATLGQFPYQARLTVNLADDKRALCGGSLLSDEWVLTAAHCVQGAKSLEVHLGAVDFNDDTDDGRLVLLSERFFHHEKYNPLFVVNDVALVQLPEKVKFSERVQPVALPTGNDDFSGRPVVVSGWGLMENGGDVAQKLQFAKLKVITNSECAKTFGPLLVKKSTVCARGDEKESPCNGDSGGPLVLADEKTLVGVVSFGHATGCERGLPAAFARVTAFRDWVNKKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WER0</accession>
    <name>A0A084WER0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00016705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WER0"/>
    <dbReference type="STRING" id="74873.A0A084WER0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016705-RA">
        <property type="protein sequence ID" value="ASIC016705-PA"/>
        <property type="gene ID" value="ASIC016705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016705"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012563"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.60:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="32897" checksum="311A45C965B5A915" modified="2014-10-29" version="1">MADVDDVISDQDKIRIASDFLMHAPPGEFNEVFNDVRELLNDDRLLKEGASAACAQYNKDQLTPVILENSELAVLITEFNDLGGGRFFDPRTKQSFKFDHLRKEATDLQNLDGDHTSEQWRAMLDIETLTYCANHYRNGSCSVYGRTVNGQITLNVCIEDHQFQPKNFWNGRWRSVWSITFPAAGGGTAELKGSLKLQVHYYEDGNVQLVSAKDCRESVPITNEANTAKEIIRLIEESEHDYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWSKIVSYSIGKELKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WES9</accession>
    <name>A0A084WES9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glycosyltransferase WecB/TagA/CpsF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016726</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WES9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016726-RA">
        <property type="protein sequence ID" value="ASIC016726-PA"/>
        <property type="gene ID" value="ASIC016726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016726"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="14224" checksum="FDE0BFCB64F95417" modified="2014-10-29" version="1">MTSRKKLTAHECRRTYSPWPSGLIEGVPFLTLLILTEHTRHGFERGRNGFLGSETETGTDWRVCRLRGLTFLRTPLEHTIDHQAVDGPDNSRKLPPKGEAEDSARIYFWTQIVQVARSPWHTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF72</accession>
    <name>A0A084WF72_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017126</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF72"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017126-RA">
        <property type="protein sequence ID" value="ASIC017126-PA"/>
        <property type="gene ID" value="ASIC017126"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017126"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017126-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6427" checksum="D0DB8F016A8C2E2E" modified="2014-10-29" version="1">MTPTSSRFASSGSARYRPDTGGGVQAAAPALGSSFLARHRTCTFEAPHLTRYRLWLAGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFG1</accession>
    <name>A0A084WFG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Enamelin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016956-RA">
        <property type="protein sequence ID" value="ASIC016956-PA"/>
        <property type="gene ID" value="ASIC016956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016956"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="8871" checksum="3D5AE7472717383F" modified="2014-10-29" version="1">MPAVFEVGSRKPLRKWSCTCSLPNVQLNVVNPSVPFAIAWLPISTTSGIRFPLFENRTQSPRPNVDENRNRAGSSAVCTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGV9</accession>
    <name>A0A084WGV9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N(6)-adenosine-methyltransferase non-catalytic subunit METTL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Methyltransferase-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGV9"/>
    <dbReference type="STRING" id="74873.A0A084WGV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017555-RA">
        <property type="protein sequence ID" value="ASIC017555-PA"/>
        <property type="gene ID" value="ASIC017555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017555"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004531"/>
    <dbReference type="OMA" id="FNSELYQ"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="44198" checksum="E690BF3005E12955" modified="2014-10-29" version="1">MSDVIKSRREKSQKRKKLLAQTFGVSSVEDLKHVLGTAEDSPNKSQKYDDEEASSSTQSQTEGMVYRDSSTFLKGTQSSNPHNDYCQHFVDTGQRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAETATPPMYLRADLKTFDLKTLGTKFDVILIEPPLEEYARGGAAVAAGAPRNFWSWDEILALDIGEVAAHRSFVFLWCGSSEGLDMGRNCLRKWGFRRCEDICWIRTNIDSPGHSKILEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIISEEAEFGSLEKPIEIFHIIEHFCLGRRRLHIFGRDSTIRPGWVTIGPELTNSNFNSELYASSFEENPTTGCTERIEALRPKSPPANGKVLRGRGRGFPRIRGRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIR2</accession>
    <name>A0A084WIR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011858-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018161</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIR2"/>
    <dbReference type="STRING" id="74873.A0A084WIR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018161-RA">
        <property type="protein sequence ID" value="ASIC018161-PA"/>
        <property type="gene ID" value="ASIC018161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018161"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004469"/>
    <dbReference type="OMA" id="FIHIVAL"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger HIT" evidence="1">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018161-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="14479" checksum="B18204772D313423" modified="2014-10-29" version="1">MCYKTHQEQPCEPVALPGEVEATILEDRVPKKTILFPTVDTVPQGKLELLGQSEHLKNLLQNPHLRRLLTEVDNGRDGMNAIRVAMMEPLFVEFADECLRIVEPPENEPQQIDLNELVFTNLQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJW7</accession>
    <name>A0A084WJW7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007045-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018550</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJW7"/>
    <dbReference type="STRING" id="74873.A0A084WJW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018550-RA">
        <property type="protein sequence ID" value="ASIC018550-PA"/>
        <property type="gene ID" value="ASIC018550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018550"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007436"/>
    <dbReference type="OMA" id="HNANARR"/>
    <dbReference type="OrthoDB" id="7776422at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF378">
        <property type="entry name" value="FI03225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784875" evidence="6">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018550-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="580" mass="66006" checksum="BC727D5D5E699592" modified="2014-10-29" version="1">MHPSCWSVGLLVFTIATGAFGAITYQCDHYEGDTYNLRYCALFGVKIVHDAEDVDFLSEYPRPYRFEFFQSNLTEIPRSLFTVFPEMQSIDLTGTGIENINKFTFENAKQLQTLYLRENKLTTLNNFIFKGCDRLLWLDLSRNRLRELKEKAFYEIPTVATLDLSWNLLEKLPEDVFSTMEKLSSLDLSHNRLTGLSDSTFRSNPLITLDLNFNRIVRLNADLLSSLNSLTSLNLKGNVLKNITLSSFPKNIDLAENNLTLILLEPRQYTVVWLNLSSNALTNVANVSVLSNLRTLDLSFNSLNTLPLTTFLSLKVLNTLNLESTNLTSLEHGIFSQQTDLLWLDVSFNRLQTFDLSVLTAASKLERLHLDGNYLTALEYRWIAELFPSLTYLGLFANRWNCSYLIELIRYCRQKSISVSPLKDYGTVLHMTNVQGIYCLGSSGAQLPSVRPVQHWENNSASSSESEEDSTETTTISSDQLLEMIRQLNQTTLQRMLKMEGERREIQSANAHPPDSSCTAMHAYSYQIFILLILSAILILNIAFLLWVQHNANARRAVDQMIVFRREHGGSVQTALNGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK96</accession>
    <name>A0A084WK96_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP007136-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00018673</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK96"/>
    <dbReference type="STRING" id="74873.A0A084WK96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018673-RA">
        <property type="protein sequence ID" value="ASIC018673-PA"/>
        <property type="gene ID" value="ASIC018673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018673"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011281"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021851"/>
    <dbReference type="OMA" id="CEIHPAV"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007198">
        <property type="term" value="P:adenylate cyclase-inhibiting serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007208">
        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000299">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000310">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="101"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="316"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB50640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018673-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="594" mass="64838" checksum="FF45A975849AC2FA" modified="2014-10-29" version="1">MDFHKAPPPRPPSLATVALSKANELYDDIFIDSGSPDSYLSADVGSIGNETFFNYSANAFANATELGPSLNGTADEPLADVIVMAVTSLVLGLMILVTVIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISRGWILGPELCDIWTSCDVLCCTASILHLVAIATDRYWAVTNIDYIHSRTSRRVFTMIFLVWFASVIVSLAPQFGWKDPEYLQRIEQQKCMVSQNIAYQVFATCCTFYVPLFVILVLYWKIYQTARRRIHRRGPKHPVTPNSSNQEETPKPKSKIRFHLKKKFTNPTKSAVSSLGLVEGNSTNTVNTVEDTEDSTNAEKKGLETTFSGDEGNNGPVLGSNKQIPTVSYEVTQRQLGDAESNNNNRATANSKTSPSGNGGTLQPPPTDTTAACPSESNQIASPLLQQSQQQKGHQEVHQNQTPKVQHTATHLTPTTVTPGAVGGPVGLQGAGGGSTLNIASTSNPHAQVSKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFLTALLLPLCESCAINDTVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGTHRSSKYRRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKU4</accession>
    <name>A0A084WKU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ubiquitin conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019022</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKU4"/>
    <dbReference type="STRING" id="74873.A0A084WKU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019022-RA">
        <property type="protein sequence ID" value="ASIC019022-PA"/>
        <property type="gene ID" value="ASIC019022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019022"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010147"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031372">
        <property type="term" value="C:UBC13-MMS2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="17364" checksum="CEA425B137B46C02" modified="2014-10-29" version="1">MAALPRRIIKETQRLMQEPVPGISAIPDEQNARYFHVIVFGPEDSPFEGGLFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAELWKVNEAEAIRNAKEWTQRYAIVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLC5</accession>
    <name>A0A084WLC5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLC5"/>
    <dbReference type="STRING" id="74873.A0A084WLC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019068-RA">
        <property type="protein sequence ID" value="ASIC019068-PA"/>
        <property type="gene ID" value="ASIC019068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019068"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005754"/>
    <dbReference type="OMA" id="GRTTKGW"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000153">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="429" mass="51323" checksum="B4FDE19E55422516" modified="2014-10-29" version="1">MTQYLPPNLLALFAPRDPIPYLPPPDKLPHEKKSQGYLGVGAFLDCFEDPKDTPPPTRVETREERLERRRRERAEQVAYKLEREIATWDPNQLLEATEDPFKTLFIARINYDTSESKLRREFEIFGNIKKIVMINDKETGKPRGYAFIEYEHERDMHAAYKHADGKKIDGKRVLVDVERARTVKGWLPRRLGGGLGGTRRGGPDVNIKHSGREDNERERERYRLEREREDRDRRERDRPENRFERRRSRSRDRERRHRSRSKDRSRRRRSRERDVEERDRWDKDRERDRDRSRDRDKDRKRKRSRSRDRDRSEKSRRDKRSDRGGERGERGDRGERGGPPGGSVGDRKERKPDFREGEIKIKEEPIDDYPDYSAQYAQYQTQVKYEDGEEEKYRPHDHEEHLLRGDNGRTGYGGNNADDDGEYDDGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMQ5</accession>
    <name>A0A084WMQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP006573-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMQ5"/>
    <dbReference type="STRING" id="74873.A0A084WMQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019557-RA">
        <property type="protein sequence ID" value="ASIC019557-PA"/>
        <property type="gene ID" value="ASIC019557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019557"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003006"/>
    <dbReference type="OMA" id="CREGNAM"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000187">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000245">
        <property type="entry name" value="Integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019557-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="448" mass="50678" checksum="97B3A31F63D25C4D" modified="2014-10-29" version="1">MEDIFHWCREGNSIQVRLWLDDTEHDMNLGDDHGFSPLHWCAKEGHTKLVEMLLHRGARVNATNMGDDIPLHLAAAHGHLDIVQMLIRHRSDVNAANEHGNTPLHYACFWGYQAIAEELVNNGALISLANKDGDTPLDKAKAVLGTRLHNLAVESGQELKKISFKDQSWSGMKTRSRDATLSRFKGINIQELTLHNKVAITPGGETWRGRWQNNEIIAKILNIRECTARVARDFNEEFPKLRIFSHPNILPVLGACNAPSNLIVISQYMPRGSLYDLLHGTAGIVVDTAQAVRFALDIARGMAYLHSLERIIPEYHLSSFHVMIDDDLTARINMADAKFSFQERGRVYQPAWMSPETLLKKRSDRNWEACDMWSFAICIWELATREVPFADLTPMEAGMRIALEGLRVTIPPGTSPHLSKLIKICMNEDPGKRPTFDMIIPILDKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPB7</accession>
    <name>A0A084WPB7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="2">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020247</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01025016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525367">
        <property type="protein sequence ID" value="KFB52061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPB7"/>
    <dbReference type="STRING" id="74873.A0A084WPB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020247-RA">
        <property type="protein sequence ID" value="ASIC020247-PA"/>
        <property type="gene ID" value="ASIC020247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020247"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007481"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB52061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020247-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7348" checksum="E99E35A2430B82F9" modified="2014-10-29" version="1">MVEQRADEILQGSENESIAFLVVGDPFGATTHTDLLLRAKEKGINTPVVHNASIMNAVGCCGLQLLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPX2</accession>
    <name>A0A084WPX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020382</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025136">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020382-RA">
        <property type="protein sequence ID" value="ASIC020382-PA"/>
        <property type="gene ID" value="ASIC020382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020382"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020382-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10816" checksum="E9744619E5771BA8" modified="2014-10-29" version="1">MPPVIPLNGTGNGIDLKEENCPFYCPHRLRSVAIRPETFGCPVENARRGTIELLAVRVVKTKIKTGEGVIVRNKIYQQANKTSGKTEKPKVLTFGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ65</accession>
    <name>A0A084WQ65_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00020601</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01025273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525379">
        <property type="protein sequence ID" value="KFB52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ65"/>
    <dbReference type="STRING" id="74873.A0A084WQ65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020601-RA">
        <property type="protein sequence ID" value="ASIC020601-PA"/>
        <property type="gene ID" value="ASIC020601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020601"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004152"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="567" mass="63018" checksum="C9E95FE2AE6C695B" modified="2014-10-29" version="1">MKVLDIFNASNLLYGARAISHSVVPTNKLPDFPLENEPVLAYKKGSKERTALEAALKKAAAKMEDVPIIIGTEEIRSKQVRHQVMPHNHKHKLAQFYYADQKQIQKAIKTATETQVKWDRTPLDERIRIWQKAADLMAGPYRQELNAATMLGQAKTVIQAEIDSAAELIDFIRMNTYYLKEAARYQPISEDLKVTRNSMRFRGIDGFIAAVSPFNFTAIGGNLAYTPALMGNGVLWKPSDTALLSNYVIFKIMREAGVPPGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWRQVGENIDKYNNFPRLIGECGGKNYHFVHPSAEVESVVNGTIRSAFEFCGQKCSACSRMYVPESLWPKVKDGLLMIRDTLKVGDVTDFSNFTSAVIDDKAFARIKSYVEHARSSKNLTILGGGKCDDSKGYFIEPTIVQTTDPTDRIMTEEIFGPLLTIYVYKDKDLDSALKLVGSSTRFALTGAVFAQDEAFLKRALDELKLTAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWATPQSIKETFVPLKEIDYPYMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ68</accession>
    <name>A0A084WQ68_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">DNA mismatch repair protein Mlh1-like isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020604</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525379">
        <property type="protein sequence ID" value="KFB52362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020604-RA">
        <property type="protein sequence ID" value="ASIC020604-PA"/>
        <property type="gene ID" value="ASIC020604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020604"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5620" checksum="9A76B5B1623CE304" modified="2014-10-29" version="1">MKGHPIWYMYCIEVHLKWAATRSHYKDGPIVNPPRPCGGEGRAEYGALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQH3</accession>
    <name>A0A084WQH3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008958-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020708</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQH3"/>
    <dbReference type="STRING" id="74873.A0A084WQH3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020708-RA">
        <property type="protein sequence ID" value="ASIC020708-PA"/>
        <property type="gene ID" value="ASIC020708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020708"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020646"/>
    <dbReference type="OMA" id="HETYPEF"/>
    <dbReference type="OrthoDB" id="7755558at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785164" evidence="1">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="37420" checksum="D3C0A0879DA0AE75" modified="2014-10-29" version="1">MFVLLILLQTFIFLQSLAIEVVYEKAEQLLGYDVLSSTLRVRKYNRTTTVLNGTFTFKVDMDDSFMIYTDFLHSSLGNQQFNMYPIKLPTMGMCKFIKFFHDNYPEVYQSIINFPEKGACPITARHFHLIDSIFPTKAIPPTFPKGLWKAVLTTKATTNLFHSSLGNQQFNHYPMKLPTQGICDFIDHVYDNYAEQIKEIINFPPKGECPVKLREVQTDFLHSSLGNQQFNQYPIKPPTMGLCKGMDFMHETYPEFVQSIINFPEKGSCPVTARDFHVIDEIFPTETVLPTVPKGLWKIVLTTKIDGMVRITLEVVVKAYSDKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQU3</accession>
    <name>A0A084WQU3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dumpy</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00020840</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025746">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525399">
        <property type="protein sequence ID" value="KFB52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WQU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020840-RA">
        <property type="protein sequence ID" value="ASIC020840-PA"/>
        <property type="gene ID" value="ASIC020840"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020840"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001642"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009722"/>
    <dbReference type="OMA" id="RVECHYD"/>
    <dbReference type="OrthoDB" id="7783995at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048407">
        <property type="entry name" value="Dumpy_DPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF39">
        <property type="entry name" value="DUMPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21164">
        <property type="entry name" value="Dumpy_DPY"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90148">
        <property type="entry name" value="DPY module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2500"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="749"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="885"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1587"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="2169"/>
            <end position="2413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020840-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2565" mass="277501" checksum="2A4F00D73C27F3FC" modified="2014-10-29" version="1">MCRCPDGMAGNAFVQCRPQQTPVVTNPCSPSPCGPNSQCREINGQAVCSCLSGYIGNPPMCRPECTGNSECPLNQACVNFKCADPCPGSCGFSARCTVVNHNPICSCPSRMTGDPFTRCYEIVEKFPPLNIPADPCQPSPCGPNALCVNSNGVPSCSCQPDMLGAPPNCRPECTSHSDCSRVLACSRQKCVDPCLNACGIDANCHVSLHVANCFCPDGYEGDPFRACTRRITKPPPQAEPKDACYPSPCGTNARCRPANNGAALCECIENYFGNPYESCRPECVSNGDCQKSLACINNRCKDPCPGVCGRQAECAVVNHTPVCSCPDGMKGNAFEQCLREEVPPPPSDPCYPSPCGQNTVCRVFNGNAVCECLPEFKGSPFGRGCYPECVINSDCPRDRTCVNKKCVDPCPGVCGYRAVCHAINNSPVCSCPSNMIGDPFVECQQAPPKDPCSPSPCRSNGICRVVGDRAECQYPECIINSDCSPNRACYNQKCQDPCVGACGLNALCNVINHAPVCSCPARHVGSPFVQCTVQRDEPPQPQPECTSDGQCTNDKACINGQCQNPCTVGTGLCTQNAECRVQFHRAICACREGYTGNAQLACYEIGCRSDSDCPATEACVNRNCIDPCRHTQCGRNAVCKSDYNHNARCHCIDGYRGNPLVGCTRPECTSNDECPYHQSCQNEQCRDPCNCAPNAQCRVDNHQASCRCPPGYTGDAQFSCEKIPVRDPAQCTMDADCPSKLACFSGVCKNPCTETKPCAEHATCTVQDTLPLRTMYCVCDEGYAGDAERQCLPVSKDEPGCYSDVECAPTESCRGRVCVDVCSNFNPCAPTAECLAQSHKAICSCPLGTVGDPFQNCYKPPVVSPECVVDADCSSSMACINERCQDPCAGSNPCGGNAECRAIYHRPHCTCPIGWGGDPKTQCYKPECKVDAECPFDKACFNEKCISPCTYGATQCGRGANCVAQSHRAVCICPPGTQGNPFVSCVTGMCQYNEDCAEHEACDRLNRVCRPVCDDETCARTATCVARNHQASCECGPGMRGNPYVECARDEPEPECRMDSECRSQQACIRNRCVNPCTELTPCTSQQTCSVIDTLPLRTIICACQTDMLMDRSGSCKPIVIEECLADTDCADTDRCQRGQCVTACKIDPCGINAQCTSVGHRAQCSCAPGYVGSPHVECLPEPRVTTPKECTVDDDCAVDRACFNDRCVNPCAGDACGRGALCRVDNHKAMCNCPNGFTMDANGNCVPPAGDLPKCRSNSDCTRSETCVNEICANPCNCGQNADCFVKDHYPVCSCRPGYSGNAQSGCFKLECESDSDCTNDKQCTNGECVNPCLLQDPCAINAECYGDRHRAACRCMPGLEGNPFERCRRVECHYDGECAKTMACQREQCVDPCANSPCAQNAQCFAMNHQAQCKCPEHLPEGNPFSFCRPRAVERDECRVDGDCPSRLACIGARCLNPCDELKPCAASALCTVQDSVPVRTMVCECPPLHVPDANGECQRVIQQTPIGVCTSDSECPEQEACINRQCRDPCSCGTHATCTIKNHRAVCSCEDGYEGNPNVACRAIGCRVDSECESTKACVNGNCVNPCLDNDPCGIGAECYARANRAECRCPSGYRGNPLVQCNVVECRSNNDCPDDKQCRNSQCINPCIYENSCSPRAECRAQNHLVVCRCPVGLVGNPYVDCRPELVPECRADTDCPSHLACIDNRCVEPCNALTPCTQPAHCEVVPSSPVRTMLCTCPDGYVSSGSGTCKPVVKAGCISDSDCSSDTACINSICRNPCNCGPNAECRVKDHKPVCSCAQGYDGDPETQCIKIECRADSDCSSQATCFNRQCVPACSMETCGPQAECIGVNHRAVCECLPGYEGNPRVACKLIGCRRDTDCPLDKACLNGQCENPCETQAVCAQNEQCQVYQHRPECACPPPFENDPLQGCVLRDDRCMTDGECPSQTACIQGDCVNPCNVTEPCGVNSNCKVLDTLPVRTMICECLPGYQGNAAIQCDKMALCPTERGFVRNSNGECVCPPGYGLSEYDDCQPCREEDGLKIDEATGRCECALERGLIRDERGRCICPIEHGYRLTSRGECIRTERPECERDEDCADWRYCNLDSKTCDDPCDRKICGTNALCNATNHRAVCQCITGYTGNPDVQCNQTTNFRTDFPQPEMVVTCQADGIQVVIGLAESNFNGVLYVKGHSKDEECRRVVNLAGDGSSTPRTEIFKVHFGSCGLIHVNGNASFVLVIQKHPKLVTYKAQAYHIKCVYETGEKNVTLGFNVQMLTTAGTIANTGPPPTCAMRIVAFDGKEINSAEIGDNLRLQVEVQPATIYGGFARSCVAKTMEESVENEYIVTDEDGCATDPSIFGDWEYNADTNSLLASFNAFKFPSSDNIRFQCNIRVCFGKCQPVNCHGANAYGKRRRRREALGIDMDRTIEIVYNRTKRAAENTALATDDDSLGMEGTLREEITIQSNPILTLEKREERSFDSNNITPAAQRVEDICVSMIGLILALVITALLALVAVAVAVSCWLMAYRRRPTITGPLPHPPEFPNPLFAHHEPSEPSHHDFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR41</accession>
    <name>A0A084WR41_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020942</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01025918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR41"/>
    <dbReference type="STRING" id="74873.A0A084WR41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020942-RA">
        <property type="protein sequence ID" value="ASIC020942-PA"/>
        <property type="gene ID" value="ASIC020942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020942"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015302"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="18760" checksum="4108902AD0046CB3" modified="2014-10-29" version="1">MIKKSFKNVFVTVGTTQFDELVRAVISNDVLEQLVNLGCETLTIQFGKGLEPDLRNANQRTTISITGYSLKSNIADDISKADLVISHAGAGSCIEVLEAGKALIVVVNETLMDNHQTELAERLNKEKCLFYCTPDTLQSTLVESDFSQLQSLAPGALDSFVDHLDKFMGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSN3</accession>
    <name>A0A084WSN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP003232-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00021535</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026629">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSN3"/>
    <dbReference type="STRING" id="74873.A0A084WSN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021535-RA">
        <property type="protein sequence ID" value="ASIC021535-PA"/>
        <property type="gene ID" value="ASIC021535"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021535"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008847"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013865"/>
    <dbReference type="OMA" id="YGDERHF"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021535-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116955" checksum="0735FA6014D5A4C0" modified="2014-10-29" version="1">MSKQEQLIAQKRQQILEKQRTLELAKQIAAEATKETPSTSTEVPEAPEAAGKVVLPFSNDGSFLERFKQLSEKIVKQTEDQVKPPASEEPDATASSEPVPLVGVSAGPSGEQMFKFDVPPPSLLPTLPPPPPPPPPQLPEMADEVHFEPFYDLPPVAPTVGSPSVDGGADEVGRHETATGEVETNFQVFSEHDKLPTTVEELIQLVADIGDVYEDKLCSRKNDLHPSLWFIFDKQSEAYRGYRRMIAVQRQSMGHPGGHPNLASGDAAFGSTGRSQLDGNGGGGTMVEEDEEDDTKYDPADVLDDSIIDDTHEDVSTQKPDGGGAEGAAAAVGETVAAAGADIPIHMMPNFYGDERHFYDDKSTTETDSDTEYVREARERNLKNLKRKTFDAGNRREDGSSTDSDDDYNGGLGDSANESMNEKNGGSSGAGGSATGGSGGGGGGGGGSRGHRQKYRKKSRWGDNTDAGTGTAGSQDGGQQQQQQGGPSTSGNVSGSFTAGTSREGQPWSAAAGGKVINMVDTSQPPPPPPPPPTLAPAAIDRNNPGLLQYVFQHYGTVADVSAECWNKAQEHYRLQLLFDDLTSKIQQHERYVRGGPAPPRGPVERGRDSDEERRLNTAKLEAIMCWINEITRLYERVRPGHLSEFLMRDDYERFIDQFRRTSDRQPNFEDYKEFRLREANGAGKPSGSGGPETQSGGPRRPEYSSTDSDFVSYPDQPPSSTMQSQQGRQQRKSGDQGETGGRRGGGGGEMGQSRVGHDPSVSSSSFAGEKRIAEEADLQQQQQQLAAKRRKSRWGGQAPVDCGPRFVPSQSPFSAGGNGPPLLSHPPPPLPPSVKAPPPAKLCAVSRTDPALLAYARQNFGTTNLSEEDWKKAEDHYKINLLYQDMLRKRQEIDRLANSGRFKYEYDSDEDTTGGTWEHKLRQQEMEATQKWANELTRQSEGKHHIGDFLPPEELRKFMEKYEAQKNNRQPNLSDYKDYKLREDNVGFQMLQKLGWKQGQGLGADGSGIIDPINKAAQRDNNQGLGIITPDNPEVNDNEYDAYRKRMMLAYRFRPNPLNNPRRAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSP1</accession>
    <name>A0A084WSP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Zinc finger homeobox protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021555</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525416">
        <property type="protein sequence ID" value="KFB53235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021555-RA">
        <property type="protein sequence ID" value="ASIC021555-PA"/>
        <property type="gene ID" value="ASIC021555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021555"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14965" checksum="5A3E81E2B158B72B" modified="2014-10-29" version="1">MGSALEHKKHQKQGRANPIQTASSIVFGFAIDQSRHTLHDTVLATDCVLSCHRKTVRPVARAPVGRMSGMWKSIQFAIRTAPNKRWGKNNETKRSAMMLMMMHLGLIVSEKETIGANKRGKHAAREKSRCPESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSQ9</accession>
    <name>A0A084WSQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021591</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525417">
        <property type="protein sequence ID" value="KFB53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021591-RA">
        <property type="protein sequence ID" value="ASIC021591-PA"/>
        <property type="gene ID" value="ASIC021591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021591"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10723" checksum="26EF6DFFEBE797FB" modified="2014-10-29" version="1">MLKDTPEGPAFRFLREPKCIISSGANILSEMVMTGSIFLVAASNKKKVHAVKRSEGYERNYNWLSLPTPGWSYVTGENHQTALCEQISLSTGYKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTP7</accession>
    <name>A0A084WTP7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021829</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTP7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021829-RA">
        <property type="protein sequence ID" value="ASIC021829-PA"/>
        <property type="gene ID" value="ASIC021829"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021829"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021829-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10362" checksum="15736D9E54C91C82" modified="2014-10-29" version="1">MLAPGTVPHMKRLTRAELDSHEPFRKIEKTGTTDDLVRPFDSPDVSEGVKSVALLPPGGPGKVELKTVRWLQCMPTATQLAEQWQKGPLGQDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTY8</accession>
    <name>A0A084WTY8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00022143</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTY8"/>
    <dbReference type="STRING" id="74873.A0A084WTY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022143-RA">
        <property type="protein sequence ID" value="ASIC022143-PA"/>
        <property type="gene ID" value="ASIC022143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022143"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015708"/>
    <dbReference type="OMA" id="FMHQEAQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001004">
        <property type="entry name" value="Protein PTCD3 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB53682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="672" mass="76912" checksum="627530D7EA329099" modified="2014-10-29" version="1">MHNLCRTLNRLRVHTCDRSLAFNRVFTASQSTTTSTAQRQPAAESNVPKEKIIIPTRIERSPTDILMALSATVGYDPTAPHYKYHDDPYLIPTSNANKKTFALAQEAGRKAAHWIRQENAKLFQHQEADPPIQAFVPTMLYTEESQVETTDLQKLIDSVEVKDAILVYNLLMKNGIEVGDELKQQMLELLCFYNHEDTLPEQFIEERWFRQGTVGRERQRKTWKDFELAEEIFHGLGEKRSEHYCAMIRGMARYFQVEKAWALYQETVEKGIELDTNTFNSLLHIASFLKESYDKRWDLVCEVLTAMKQQGLRPNLGTLNGILQTITTIGGYNHPRTYALKTLAEFKKLGIEPSLASWYYMLVIFCRERGPVSHVLHDIMNEVEGKAFTIQDPKDTFFFVTAMDVCRNHLHDKELAKRVNQLLHHGENYNLIGDSYKESIYYRHYFTLLATTEPLESFLETYHLLVPNVYIPEPSVMEDILKSVEMNTAIEHVPLLWSHMVQFDHTGRENLVNLLLHIMVSNQPVADEPRHADLVQRFANIGWDLYSRLEERATAPRATSSGLSGPMLGDILLLCARANDYEKAMGIFTKLSKEQNSVIGEPRVDGLREFINLCITNRTPSMAIQCLAYCSENGYPESAELGRHIFSSFALDQNLVAKIKSLVGAEAVKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU47</accession>
    <name>A0A084WU47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022120</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022120-RA">
        <property type="protein sequence ID" value="ASIC022120-PA"/>
        <property type="gene ID" value="ASIC022120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022120"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="8777" checksum="241E98A793D4041B" modified="2014-10-29" version="1">MRIIARVPENPAELGISSPQMVMTLDTTGGSPGKGKFRHQRYARPLALRLNRFGARHLCGIRIGSFTCGKTPGIPADASGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUA1</accession>
    <name>A0A084WUA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Acetylcholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022032</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027025">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022032-RA">
        <property type="protein sequence ID" value="ASIC022032-PA"/>
        <property type="gene ID" value="ASIC022032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022032"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9389" checksum="F7D87FD2661403BC" modified="2014-10-29" version="1">MVPTSAARKLEFNQGKVKEIAKEWQGVKTSLGQEEYVIPFGPPSAPTALSCADEEPLDGRTVQSSARSYTGRPKPSGASKPKGRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUI5</accession>
    <name>A0A084WUI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Pre-mRNA-splicing factor CWC22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022324</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022324-RA">
        <property type="protein sequence ID" value="ASIC022324-PA"/>
        <property type="gene ID" value="ASIC022324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022324"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5774" checksum="F8B6DBC27B8B2B63" modified="2014-10-29" version="1">MENLSATGFFTAGPLPTRGHLSWVECLHDLPAFCIQPVPLPAAVHCCSGERTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WV28</accession>
    <name>A0A084WV28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Outer membrane protein PgaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008797</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016325">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL646763">
        <property type="protein sequence ID" value="KFB54072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WV28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008797-RA">
        <property type="protein sequence ID" value="ASIC008797-PA"/>
        <property type="gene ID" value="ASIC008797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008797"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB54072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008797-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8512" checksum="3273318001652125" modified="2014-10-29" version="1">MFNYQTNIPYMPPKRITTVDVAARPYHLIHQHYYKQHHQQLQLLQLPLVVTATITTSISTSSTPLQATTIYSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA22</accession>
    <name>A0A084VA22_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000266</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC000266"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS007798"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="349" mass="39313" checksum="4D3941E60A36E0E2" modified="2014-10-29" version="1">MTRSRPFLLSDGCACCCYHPTNPIYQTNLIVNQIPFMDDELDEASVSSNFRRSHHFPIRHRRSARVDAIGPGALPPQALFRKNNLFATANARDDDGPFRPRSHTFNQSKVDDETVSMPNSIEYDHSGSVPELRRPRVPQRGRKMGAIYGNVALNVHVSNGMGTVAEVDDDVQPRVPPRRRYGMAQGKINPQDLAADRASQSSCLVLGMNSDARNPLNYKMYTPYYNKRQTMPVEHFRNWPPGRLEDEGDESENEFNRRALSYYSQVANQLDHYERRSFDTGSSTVLQAIDSNSILYRSDRDGLHRISTGGDEDPDARMHGGGRESRVSAXXXXXXXPKQAKPGPSKDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA33</accession>
    <name>A0A084VA33_ANOSI</name>
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        <submittedName>
            <fullName evidence="7">AGAP003537-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00000331</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01001577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01001579">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01001581">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523980">
        <property type="protein sequence ID" value="KFB34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VA33"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000331-RA">
        <property type="protein sequence ID" value="ASIC000331-PA"/>
        <property type="gene ID" value="ASIC000331"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000331"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009996"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016099"/>
    <dbReference type="OMA" id="KPNGMTT"/>
    <dbReference type="OrthoDB" id="19132at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001861">
        <property type="entry name" value="Protein tramtrack, beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001537">
        <property type="entry name" value="Tramtrack, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF82">
        <property type="entry name" value="PROTEIN TRAMTRACK, ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
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            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1137"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="426"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1191"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB34827.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000331-PA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1288" mass="136259" checksum="04C816B493AC43BF" modified="2014-10-29" version="1">MSSQRFCLRWNNHQTNLLSVFDQLLHDETFIDVTLAVEGQHLKAHKMVLSACSPYFQQLFVNHPERHPIVILRDIPYKDMKCLLDFMYRGEVSVDQDRLAAGPPSSSSSSSPSAGGGATAAAAGSTTTQSTGSGGGHTTGGAGGAGGAGGAGSAGTRGTHTAASTVAASTQGGSTGSVVSAASYTDDGRTSPALGSINAGTSSPAQAQLGGSQLKQLPPLIAASGIVTRSHSNSLLHQNHHGTGGGSSMLQTNPLLGSALSQQKRKRGRPRKLSGSDTGGEGENFPGADEYDSSSMDVMDVKMATGSGGSNSGDEEGSGQLRIVTSRSGEDDEVVVHHRRRADGGDDEDAIDDAEDLVDDEELLDADEQQDDEREEKDGATPSVLDDSMEIGEQHQLANNNNSNRNLKRQQNNISKLRSASKRSKTTVASSSTNLRNNENSMSDSKDSFVEDDNGIQMEETGGEEEDEDIEEDQYDERELNSSLMEPQLLLDEFDEPVEFKFDPRGDSGAVDSTSNSSYPPPPMQPKPGLKLAAGGPASAAGARMPQISVVPTTALQIPKLAPLTDKAAGGAPTRAHKRTRLLAPKKPNGMTTTQTILNNLNNNLTESLISTSNAGGAGGQLPLPGLGSEMYDMFSSSVLRSSSPRSNSNSPSVRGGGGGGGGSGAGSDSGSRPHKYAVIDDAEGSVRDFCTKEGDHVYRCKVCARVYTHISNFCRHYVTSHKRNVKVYPCPFCLKEFTRKDNMTAHVKIIHKQEFAHQQSPGVGPGGTSPAGSNSRGEDKSFSASLLLGGKPESSSTNGSAASNTASIINAVGLQPKVPSGGGGGGNIRIVFPFPTGGQSSSSASAAAANTNSGSTTTSSSAGISIKKEFQDKSSANSSGANSPTGSVSSSSSGLAAQQPATATVSAPFFPCFTTALSIFPIGNGNGRAREAEIVAEVDEDKSILKNPRKETMLNTHQALLDRLDRQELTITERPALNSGNGVPSPPSHGTDSCCSDVEDIEALSEFGVPSPNGHSAAVANGNDFLDSTNGTITPCGNVGHAKTISPDDPAEALTEMSVRGLNLFRYATVNAGVYECRECSKEGAQKTFKNKYSFQRHAFLYHEGQQRKVFPCPVCSKDFSRPDKMKNHLRMMHGGGALYEPKGGDHPVTNAPDGQHCFPPKPKVDMMQLHLHLQQRQLHHLQQQQNQHGEGHQLQEELDKRRQQEQDVLKIRQAVNAITLRQLQQLRSQLQEKVAQPEQSHHHQQHHPHLASEQAVALGQQRISNSNLQTSVPSQQLLALGGLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA43</accession>
    <name>A0A084VA43_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000342</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01001625">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523987">
        <property type="protein sequence ID" value="KFB34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000342-RA">
        <property type="protein sequence ID" value="ASIC000342-PA"/>
        <property type="gene ID" value="ASIC000342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000342"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000342-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15694" checksum="0ABFDC43979E739D" modified="2014-10-29" version="1">MNHGNVSARLQLASPCRKDSPQSLWWRAVHLQQHHAHVDLDLVRLRSPVCPRPVATVSSSRLIYTFGATAKPEGVCVNDIRSVSLDRLAEVVTWSRKGRRVRIDFGSVTLRYASSKFKCTNDEQELRPQTGKESARSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBN3</accession>
    <name>A0A084VBN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524468">
        <property type="protein sequence ID" value="KFB35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001894-RA">
        <property type="protein sequence ID" value="ASIC001894-PA"/>
        <property type="gene ID" value="ASIC001894"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001894"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001894-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9468" checksum="922DC4144354EA42" modified="2014-10-29" version="1">MESPLTTGERQTTTKRFDNDLNRLRSGNVDGNAIFHPMAKNTCDTRRRHFPLPIPPFTHSASERDFSRWGSDLPGNRCKDTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC20</accession>
    <name>A0A084VC20_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP003342-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00002281</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01009982">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524560">
        <property type="protein sequence ID" value="KFB35514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC20"/>
    <dbReference type="STRING" id="74873.A0A084VC20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002281-RA">
        <property type="protein sequence ID" value="ASIC002281-PA"/>
        <property type="gene ID" value="ASIC002281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002281"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023640"/>
    <dbReference type="OMA" id="NTACRML"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.20.110:FF:000001">
        <property type="entry name" value="DNA repair protein complementing XP-C cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018026">
        <property type="entry name" value="DNA_repair_Rad4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00605">
        <property type="entry name" value="rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="12">
        <location>
            <begin position="1096"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB35514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135961" checksum="0F6D7ACC8F5D09EB" modified="2014-10-29" version="1">MSDEEENFTESEEGSDFSASEEDEWVPTKDSKKKQGAKKSKDESSSDTEEDDDDSFSEDGSDLEDFEETSKKKKSKQSTTRKRPAAKTSPKPAGGGGKRKRLSPGLRDRLYQQYKKDLLKEIAPARPPLNSSVSAILQKCQYQRKGGSVGSQSKAEDSDSSGDDHLVDPEKLDLGSTFFNKHDKAQPTSESGPPQFDVNAGMRLSDSSDGEDPEPRSGRTGEEFLPASIPRQAADKLISHINQQSGEFMNFHNLDQFTAKVEEAKRFLKNYQQKEAENVNTESLGDSATKHQKESVSNLLALGETDAGVSPRKVQSNASSDSEWEEVQTEEGAERKPENDSKPKDVTIEMDTAQSRRKRREELEMELYIKRQINKVKRANQLNYHKSSVLAAVAIGRQLNHIIGGGAIKGLLISIMQEKVSVGSTKWDEKKVPSLADWFRAEFTLVSNDYLGKRNGCSLPFNLSLALYTRKVNCRRDYILLFLACLRLAGAQARIVLSASVPSKRPAMSDLCPMSERQIKENTEKRLSNGAQVEHPLGSVQKQENDCAETPKPNAKIPENENVEQAACKTTPTKENTSKEPLKGTTQKVATRRTTRRALATLNIPQLDGGDDVTLETALNVIPLRRSLRSSSASAVPVASPGSSPFTKRKSNTPGSANTVGIGKTKAIGTRKRKLFAPRTEPKDLVVTAMTTESRPAACSSTRKQAKEQLETKQTLGSADKAKDGKFKRQITRPSTPSDDDAFVSKASTIEQKEAVKGARTVKTEEKPSNVANKSIDRKVLSSDSSSEGESAKGKRKLATKNNHDPPTRKVKTKRAAKKKQAYSCSDDSDADSDFELPTSTSKRTKKSPTASKGKKSPAVKRGGGTSAGARQASGEKTDLWIEFYCEKSKRWITFDLASGRTDCVDYIVRNATSPISYVFAWDNGGIIKDITARYVQNWNTACRMLRVEQAWLDKVLAPFVGAKTNRDLLEDKELNKLDADKPLPKTIGELKNHPLYALRRHLLKFEALYPPEPPSLGFIRGEAIYPRECVHTLQTREKWYKQGRVVRPFETAYKVVKCWKYDRPNNNWLKDQPCDIFGFWQTDEYDPPTAENGLVPRNEYGNVELFTEKMLPKGTVHLKLPGLNKVCKRLQIDCAPALTGFDMAKMRVVPVYEGFVVCQEFAEQVVEEWYKEMEQEERREQEKLEKRVYGNWKRLIKGLLVRRKLQNKYNFDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC64</accession>
    <name>A0A084VC64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002396</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524585">
        <property type="protein sequence ID" value="KFB35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002396-RA">
        <property type="protein sequence ID" value="ASIC002396-PA"/>
        <property type="gene ID" value="ASIC002396"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002396"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783524" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002396-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11091" checksum="96310979D6DB3AF3" modified="2014-10-29" version="1">MKFAIVLLLALFAVACIEARPHPTEDDDAVAEVSAESAEESEVAVDAEADASAEIGIEAEIFDELVKDLESTPEGRKINWGKILLAAAEAVIDQIKSNKTTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCG0</accession>
    <name>A0A084VCG0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002526</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010701">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524603">
        <property type="protein sequence ID" value="KFB35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCG0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002526-RA">
        <property type="protein sequence ID" value="ASIC002526-PA"/>
        <property type="gene ID" value="ASIC002526"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002526"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759802" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002526-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6767" checksum="315ABF78BB19AB8A" modified="2014-10-29" version="1">MSLLSSGLFFFGWLDVQPETPFRQKTSDGSTWENRFRGEPLFTSSCSGISGNYSVKYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDF9</accession>
    <name>A0A084VDF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002982</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011324">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524662">
        <property type="protein sequence ID" value="KFB36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002982-RA">
        <property type="protein sequence ID" value="ASIC002982-PA"/>
        <property type="gene ID" value="ASIC002982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002982"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7498" checksum="C3EADCB0E282D3FE" modified="2014-10-29" version="1">MCNQHDEDSPSCTQNNGLGLGGDDVGTNDSVQHMGNNDNSYHHGQCDTAERCSLTSGDARYLNYAGTFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEW8</accession>
    <name>A0A084VEW8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00003647</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524783">
        <property type="protein sequence ID" value="KFB36512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEW8"/>
    <dbReference type="STRING" id="74873.A0A084VEW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003647-RA">
        <property type="protein sequence ID" value="ASIC003647-PA"/>
        <property type="gene ID" value="ASIC003647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003647"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015330"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB36512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="36217" checksum="2BB2449A5DD3F17B" modified="2014-10-29" version="1">MEMLLFRSSQLQMHELHGGKDFSFSPRGGGGPRGRGGSGDGGGRGRGGFGDRGGRGRGGFGDGGGRGRGGGGSRGGFGGRGGSRGGPRGRGGRGASRGGKPGGFKGGKSVIIEPHRHTGIFIARGKEDALVTLNLVPGSEVYGEKRISVETDGDKKEYRVWNPFRSKLAAAVLGGVDKIHMPPGSKVLYLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLLNVAKKRTNIIPIIEDARHPHKYRMLVGLVDTIFADVAQPDQARIVALNAHNFLKNGGHFVISIKASCIDSTAAPEAVFAAEVKKLQSEKLKPQEQITLEPYERDHAVVVGTYRALPKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF51</accession>
    <name>A0A084VF51_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative L-carnitine dehydratase/alpha-methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003791</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VF51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003791-RA">
        <property type="protein sequence ID" value="ASIC003791-PA"/>
        <property type="gene ID" value="ASIC003791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003791"/>
    <dbReference type="OrthoDB" id="6331612at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="163" mass="17911" checksum="A8C9B761ABA0ADB9" modified="2014-10-29" version="1">MKFVTFVATDHRPTGPGKTYKVVIEPHIFVLAVAEHHPGEYIALELAEGGDLEGLKLRILLRFASAACPGRDDHHNPPECKRQFTNRVSTKTFSTEAKFPSVANGTEGYSLGAAPGTEVQQCNDECHPTVGSSLSVQIFFKHKSILFQVIIIHLREGGDSREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFF5</accession>
    <name>A0A084VFF5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003848</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFF5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003848-RA">
        <property type="protein sequence ID" value="ASIC003848-PA"/>
        <property type="gene ID" value="ASIC003848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003848"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003848-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9005" checksum="843681DBF0459434" modified="2014-10-29" version="1">MLRPSAAAGKITFRATYRSFSALGKWKTLSSLQPRSAFYHVARVGFRDPCPSPLQLEYNIPDERDIAIGKAMEAQERTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG52</accession>
    <name>A0A084VG52_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004120</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36946.1"/>
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        <property type="protein sequence ID" value="ASIC004120-PA"/>
        <property type="gene ID" value="ASIC004120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004120"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004120-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12200" checksum="A07E70A52ED84CC7" modified="2014-10-29" version="1">MAHQRSPVRIRYSVWKLALPKTLCWELQLCTGYPSARAVLLDGLLAVAFGMQTSHHGFRVSLTTVVGEGDKYFTPERHENASAPRNREALKFGTKNRAWQLEDMSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG69</accession>
    <name>A0A084VG69_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Tyrosine-protein kinase SRK2</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00004133</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC004133"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS003521"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="21013" checksum="9E628D4C47EA7E04" modified="2014-10-29" version="1">MCERNVVKISDFGMARKVIRGCIYHKQRNDPLPVKWLALECISCRKFSTQSDVWAFGVLLWEMFSLGAVPYADIQTYEELYRLLRDGYRMEKPLYADEKIYDIMLSCWFVNVDLRPLFDKLASTFNGMLPSELWNRYIVLNELYERSNHLREQPPEIECSLEVGSPAEVAPPIPTHHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGY6</accession>
    <name>A0A084VGY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004444</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004444-RA">
        <property type="protein sequence ID" value="ASIC004444-PA"/>
        <property type="gene ID" value="ASIC004444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004444"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004444-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7872" checksum="0CF2C8839E6B8418" modified="2014-10-29" version="1">MNQISAEKINDPIRPAHGYRMMRAAISLLLRRSRRVIDTNLGVVERARARGRWKKARTKEKRERMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGZ0</accession>
    <name>A0A084VGZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013476-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004449</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524840">
        <property type="protein sequence ID" value="KFB37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004449-RA">
        <property type="protein sequence ID" value="ASIC004449-PA"/>
        <property type="gene ID" value="ASIC004449"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004449"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015691"/>
    <dbReference type="OMA" id="EPAQFYS"/>
    <dbReference type="OrthoDB" id="6507260at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004449-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="661" mass="72786" checksum="BCE0450DFD1FDE64" modified="2014-10-29" version="1">MRQHQQQQPVRNFRGVRKFRHFFYEQPENDDTILPIEALFTSKEDMSPSSTQFYGNRRDQRQQPRVASGEPKRQPLPIVGYSESVTLPSALQSETLQTNDIDESETTTVSSPEATTLATVTSAPMASEFAGAKKDNISTTTTATTPTEESTAPYGRDFSPTPVTDEQSTSTETGVHAPRSNVRSAKSAKVTQVSDERDQGMLPVLHSSNSHRSELSVEELDPTINRDETVPVEKDSAAEVQRVTSSPPTTLAPAPSDISDRMQDSAGSPFVQPFASQQRNRMQRKQDTKGTFQSIVYHERKDLMKSSSSLSYSYLGETTPTVKSWRDINEEYSLNRKRSSSVPPSSFGGSGKPADIVPEQETRKSVVYSEPARFYSEPAQFYSEPAKVYSEPAKIYGEPEKVYSQPAQVYSEPAKVYSEPAKVYSEPAKVYSQPAKIYSQPSSYWQTAYAITDSTEGQRATTASSASPSDGTSPAGLIPSTTTGAPQLQQLDSNGLGQNQRQRLVFNELDKIPYDQLNAPTVDSDTDSIHNAIGKFVPKQSHTAGTDEEELAGQKMLDAAHRVGADPVYEAKQQDEQQTPAAVQPLTPVVGSGDDAKVGYVVEGRNYRKYRVEEKTPDGFIVGEYGVLSHNDGNLRGVRYTADSDINPRLIYDALLKFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHJ6</accession>
    <name>A0A084VHJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Guanylate-binding protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004574</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004574-RA">
        <property type="protein sequence ID" value="ASIC004574-PA"/>
        <property type="gene ID" value="ASIC004574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004574"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759832" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7327" checksum="3729FFD5185EBA50" modified="2014-10-29" version="1">MATMAVQCLLLLCSLMLMTVSGALYERRVPLPGSLSHPDREMILKSVASRWGPAGCGIGGSTGGGPPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHN0</accession>
    <name>A0A084VHN0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00004712</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHN0"/>
    <dbReference type="STRING" id="74873.A0A084VHN0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004712-RA">
        <property type="protein sequence ID" value="ASIC004712-PA"/>
        <property type="gene ID" value="ASIC004712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004712"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010501"/>
    <dbReference type="OMA" id="IDNLWDV"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="693"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004712-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="844" mass="94279" checksum="E2CD9BFC7C8E5C6F" modified="2014-10-29" version="1">MEANKTAGQAGAGAGAGAVPVVARRRRRVARQLRESTPDPARDGSVGSRSNSCDDQSGSDETRGTGRSTVESSPSSSKKSLIERAIEYGSAHRNKILARKDKKLTIVAPRSRSVPRDETEVPSSPEIFSLLRRAKRSLSTARKPKTDDSSDGGRISDTEVRQRRERIERFRSERAGEGGTEGKPAGPLQANLQRFNEERRRFELEKLKFLQEKRELDRMRLRRFEKYREEMLEEQSRKLQAKLQQERARSIEATPMPPLAPSAAHRSHTPTRADTLSPPTTKKKILIVPKAPHRTSSHSASSSEDEGRLSSDEEKKAQLTVRRRFSPRKPPKRPRSTKLEPMKPIPAPDTGITSPESELPSDFQPEEPEAATKPNQEVQEKADKEPEMVLTHRRVAGKEHEDKIEEKNEVMEQSISTAKEIELKGEELPVETIDSKDATAIVKDGKGKLRRRPLVPYVEKPGEVFGWGEIGKEMVDLWRDFLDDHPEDIVRMRVQVNHCLFYFGVMVLLCGVGGIVFRLTEGTFESQYKCGVRRVKREFIDHLWLSSHNQREEDWKLSARNRLRKFEEELQVAFEAGMKSYSGNTAWNFINGVIYSLTEVMKGLNVVYDMVRRPSADNELQGATTTTATTIPQQTAPPAPSQTYRTQAESQPTAATGGGIETVPVPETPTTPIPETFEIDDEFNLPISVAIVILVGYMLFGATIYCTWENWSFFEAFYFVFISISTIGFGDYVPQHPIYMMCSILYLIFGLALTSMCINVVQLKLSDSFRQASAKIGATIGLQMAEAEMASQHHSPVQTPIEMAGVHTSTPTSAANVSLNGTVSSTPALPARPSSSVSKPEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHP3</accession>
    <name>A0A084VHP3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00004708</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHP3"/>
    <dbReference type="STRING" id="74873.A0A084VHP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004708-RA">
        <property type="protein sequence ID" value="ASIC004708-PA"/>
        <property type="gene ID" value="ASIC004708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004708"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005438"/>
    <dbReference type="OMA" id="EISAFAM"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049135">
        <property type="entry name" value="TEP1_CUB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21412">
        <property type="entry name" value="TEP1_CUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="9">
        <location>
            <begin position="249"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="10">
        <location>
            <begin position="454"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004708-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131228" checksum="BDA408FBB3ABAFCB" modified="2014-10-29" version="1">MKWSVLVPEKLADGEYMISIDGHRGFAFHEDVPVVIESERFSGLIQLDKPVYVPGDTVNFRVIVVDSDLKPPKRKYITVTIITPSDALLRQWDAAPLNIGVFEGSFQISALSIFGTYKIVVESNGDRLVSKTFEVKEYVLPGFDVDVFPTRVPLEKHQAVDLTVVAKNVFGKPIEFHDGSPATNVKCIVQVEGTEENEFERVSDNNGEILLQLTPSESEDVITLTVLVDGQEILEEEISKAEFKTKSFLKISLKSRAQVNMPIRLNINCDKSVTFFMYYVMAKGNIIDQGYVSVTRRTSANIYVQYSASMVPKATVFVVTVAGDRMVYDTMDILFEEQVNNIHVDIQQKQVQPGGHVNLNVRGRQGSYVALAAYDKRLREYGSIHDLTWKDVEMLYEHFYSIEEDEYAEFDIFEGFGLFARLPTNIKINSVVRRADRYDSFANPIQYRNDFAESFLWKNLSLQHSDQITLVERIPDTMTTWYLTGFAVHPEYGFGIVKQPVEFTTKKSFYIVDHLPYSIKRGEVVELSFTIFSNHKDSAVQVRLFNIHQQLEFIEQPFNDSAKIKYVVTQQKFGAPVTFKVKAKKLGPIVVRVEASYLLENDTIVKVIRVIPESLMKRGSESLMFHSQSYVNQIFEFDLHIDHHADVGSTKIQFIIKPNLLEAIEDNLQNITSTMGFEVSNTLIDFASNVAVLDFVTVAAKKYPEYQKLGRQSGLTSGYRNLLRYRKFDGSFNAYGSGDSSIFVTAFVVDVLLVASRYLGEVEERPIQSFDWLASKQHSSGRFEEIGPIVVQELQADPINCIALTSYVLIAFLNFEPIRNNYSEVIQKGIDYILNHRNDNGDTFHLAIVTYALTLHDPKSDAAVNSLLKLMEKGHMSEEHMYWPSESHTIATTAYALLSMRYNENFFVNQILTMRWLVKQRYTYDSFPRALDTYVGLKALTGLAEMIASYHNDYDIVFTILHNKSFRIRSFLINSYKNSYTGKFEDIPSDTRRVKINFAGKGVGLFTINYMYSVDLRNHIPQFMLTLEKFKTKSNYELKLKICANFIPSLLQERINVSLIEVTLPSGYVVDNHPISNATGVSSIEKIDIQYGATTVFVYYANMGPDPNCFTVTAFRELKASYRCPAYVIVKDFFHPEINAIKVYDVDQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHY1</accession>
    <name>A0A084VHY1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP011348-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00004812</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHY1"/>
    <dbReference type="STRING" id="74873.A0A084VHY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004812-RA">
        <property type="protein sequence ID" value="ASIC004812-PA"/>
        <property type="gene ID" value="ASIC004812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004812"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011360"/>
    <dbReference type="OMA" id="FHNGNWE"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF264">
        <property type="entry name" value="MIP05773P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783507" evidence="7">
        <location>
            <begin position="21"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="572" mass="64622" checksum="72C2EB9378BED8A0" modified="2014-10-29" version="1">MKLMTYIVTVWCSLWLTVDGNTGHSERPNIVIIVADDLGWNDVSFHGSNQIPTPNIDALAYDGIILNRHYVPPLCTPSRASLMTGRHPMNVGMQDHVIISDEPWGLGLDQKLMPQYFREAGYRTHLVGKWHLGFFRRAYTPTFRGFDSHFGYLGPYIDYWDHSLQMNETSARGLDMRRNIDINYAANGTYATDLFNDEAVRLVQAHDKQQPLFLVLTHLAPHTGNEDDPMQAPPEEIEKFNHIKDPNRRILAAMISRIDAGVGKIYRALEQRSMLENTIILFYADNGAPTVGVHANSGSNYPLRGQKESPWEGGVRGAALLWSRLLPRKGVVSEQWIHVSDWLPTLGYAANIRIPPRGSAIDGQNQWKTLQSISAGGRSVVMNNAHEEFIYSSYIKRGWKYVNGSSMEGHYDGWLGQIDGTEGLSADEYYGRLISAENIGSSLNFTRDQVEETRHSATVQCTNEIDQTACEPLVSPCLFKLAEDPCEYNNLASLYPDLLRELEADVQHYRERGAHSRRKPADSRANPALHNYTWTWWQDELTVKPPHSGPVANFMAALQNLVTFFASLFSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ30</accession>
    <name>A0A084VJ30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005146</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005146-RA">
        <property type="protein sequence ID" value="ASIC005146-PA"/>
        <property type="gene ID" value="ASIC005146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005146"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7768" checksum="D3D4B427FE8EBCD9" modified="2014-10-29" version="1">MPPSTSMRAHPANDVSFSPTKWLTKVRIKVVDRCRTLWWLGSGALAYIPRPASVVTERIPACAIHPGLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJS4</accession>
    <name>A0A084VJS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004323-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJS4"/>
    <dbReference type="STRING" id="74873.A0A084VJS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005532-RA">
        <property type="protein sequence ID" value="ASIC005532-PA"/>
        <property type="gene ID" value="ASIC005532"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005532"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000816"/>
    <dbReference type="OMA" id="PPKTQSC"/>
    <dbReference type="OrthoDB" id="6126662at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF11">
        <property type="entry name" value="FI13065P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005532-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1177" mass="123023" checksum="73B4AD4E82C28C84" modified="2014-10-29" version="1">MEPGPPGSTSTVPGGGAGGSGGGIVGALAGGSGGGGPIVGGVGGTSAGVVTRPPITALFREIHKNTWLRRLSGDSRRPSVLNKKPDRYWVVFCVHDDCEALLEGYSDPRQAPSHAPEWSLSLQTVQHISHALVPVEQEFEFVITLGSEVARFNANTWECMQEWVECLRAKLREMKLLSPKENLYSRLPEVRPPLAPTRDPTSPLPATPPVPAALVPGIERVQHHHINQPAASTSGHSSLGPVGLASSSATPQPASLPPLLANNGSASNTGTTSSTSSSSSSSSSSSSSSSSSSSSSGSYSSTLTSISSCVNGGPPAMSNTSTQNLMNLLSNPLQAVSSISAQSKSGPTQPPDNVSLVSCSSSGSSSATSEAGGLEELSEDLLKRIINPNTVATPSSLNLPKPQKIITRENGHANMTLASGSSPPVTSSLATTFVNNVLADPSGTAGASVKRTGPATDKLLLDVRGGPSERTGCDDDDVGNNERDAKKDAGDAKRTRRKISPLAMQSLSPTASNEELPSNVTIIQVSNSSVTTTPSPTVTTSPKPVSRFIFTKAKPTTMTTPAVIVKDGGTGNNGDTLATDHNYRSNVQIIPSNVEYERQQPIASTHGTEDHLLMQPSIIASINEQQITTVTVPNVSKSVPMPALKAAPSLKAPVTTAAATVQVAVATSSTPIKGPENNFGTVTQIAVNSSPNQQHYEQVFLSTTHTPPSVQVTTSSGSGRGTGGATEQLVSVTPVGVKPIAGNKSSKVLLLSKQPRSSSHSEIALPGRATVKGGKPCPAHPGSTASTSKHPGGGVQPSASSPAVPLHLTGGSPSKRPAVDRNIYTPHPQRAPLLQRGLTELVLSTRASPSATAGHPEHPAQNGGRSRRPPVESKMIRNEPLPPEQRRRSSSTSDARQEHPARINGTQPAAGGGGGGVVGRLQSPPQPFRPHHQLINVPEGQIANGVGGITPAQIGGGGPNRKLTLREQQVFQLRREMMHPGGVRLQLRRKDCINSIGLVDAFGAVWVAGWKQKEHPVLYNALHIGDQLISVAGVAIASSADAHKAIRAAPGLFVELIIRRVPFGRVYAIRREIDGQCLGLIRDGNTATIVDVVPNSLAARHGLPPKAKSCDGLSLTFWVLTEINGRPLNLFFKENEIRDRLNAVGRDISILVQPADLVTKLKKQLKSLRGHKDFIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKM8</accession>
    <name>A0A084VKM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">MltA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005931-RA">
        <property type="protein sequence ID" value="ASIC005931-PA"/>
        <property type="gene ID" value="ASIC005931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005931"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12472" checksum="8FBB8B1F42D09190" modified="2014-10-29" version="1">MPVLREAEQCTTVQRKHSGSAGATAEKGTRFGTSWKSRRCHRESFFAPGPQTKSRGFDLPIPDPLMMGFYKPFSDLSPSRAPCNVTSMLDDSTEPNGWCSVLFPALAGFPGTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL26</accession>
    <name>A0A084VL26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008932-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014399">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL26"/>
    <dbReference type="STRING" id="74873.A0A084VL26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006064-RA">
        <property type="protein sequence ID" value="ASIC006064-PA"/>
        <property type="gene ID" value="ASIC006064"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006064"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007048"/>
    <dbReference type="OMA" id="EIRCLRW"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB38670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006064-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="408" mass="45932" checksum="96FCA9D6139CAA87" modified="2014-10-29" version="1">MAAEIKPAPRSANDRFCTTKKPELLSKLEGCNDDVNAAVLIPGEDGVISVCDGKTIRVWQKRDSGQYWPSICQYMPSGCTSLCYTPETRTLFIGQENGTISQFTLSDDCNRLTPIREYLAHQARITNVTFAKHTGWILSAGRDKFFAYHSTETGERIGCYTFEAMCTAMQYDALSKYVFVGDYSGQITMLKLSATGATMVTTMKGHSGSVRSLYWAEGPQLLFSGSQDQSVIVWDVGGKRGTTYELHGHNNKVSSLSYGSNTQQLISAGEDSVIVFWEMNAMRKVTPDWVESDTCQLCTRAFFWNFRAMIDQKQIGIRQHHCRYCGKAVCDKCSTNRINIPIMGFEFDVRVCDQCHQRLKSEERPSLATFHDAKHSIVAMDLDEPRKRLLTVGQDRIIKIWDLSSIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL34</accession>
    <name>A0A084VL34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP013497-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006073</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014403">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL34"/>
    <dbReference type="STRING" id="74873.A0A084VL34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006073-RA">
        <property type="protein sequence ID" value="ASIC006073-PA"/>
        <property type="gene ID" value="ASIC006073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006073"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011212"/>
    <dbReference type="OMA" id="ILYAMRG"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="15627" checksum="B964DB3FA93775C7" modified="2014-10-29" version="1">MGRRKKRNDQLQTANDADVAMQQQSEPNTEQDDPYSIPLHSRQAAFAILWLLVYSFAMFTLPFGAFYGMKSLLLEQFQIDGFNNTCGSVLAAVLTVNGIIILYAMRGFKEVEEEDRDRQMRKANDDHIVAASESSKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLN1</accession>
    <name>A0A084VLN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000234-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006366</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014528">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLN1"/>
    <dbReference type="STRING" id="74873.A0A084VLN1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006366-RA">
        <property type="protein sequence ID" value="ASIC006366-PA"/>
        <property type="gene ID" value="ASIC006366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006366"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014837"/>
    <dbReference type="OMA" id="QNRTHIF"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006366-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="374" mass="42361" checksum="9268F1A11357510C" modified="2014-10-29" version="1">MGNVGIRSTGPATSCDRNDDTVTPPETHGTHRSSGGTSECDRADRTRTDSVSASASAQHPDQAGQAAKRKVVTFQLPPSAEDAHVSWLRLRYHEAVARLARTEWLRRTVPVLANALHAAGEVTPPNRTRTEREGRSRRRAPYRVRPLARISRRRWHQKTLVSDTQLLKTSWPVRQTEQLFLPTFPVDERRDRRYGNRVHVANGAFGRVFQVGESANPEQTARPPSQYALKVYRKSDIVYSGAVQQLVDEVNIQTICGHHPFIVRCVDFWQSRTHIFLLSNYYGNGELFQRLKTFCSELSRLYVAELALAIDFLHNAGIIYRDLKPENILLDDDYHIKLIDFGLSKWLRIGSRTSTLCGTAQYMGKGSFPKHTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM39</accession>
    <name>A0A084VM39_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase 16 kDa proteolipid subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Vacuolar proton pump 16 kDa proteolipid subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM39"/>
    <dbReference type="STRING" id="74873.A0A084VM39"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006744-RA">
        <property type="protein sequence ID" value="ASIC006744-PA"/>
        <property type="gene ID" value="ASIC006744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006744"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003131"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006744-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="208" mass="21733" checksum="1E37DA6DC236CC52" modified="2014-10-29" version="1">MRYTLGYIFSASFVSVATVLILYHVLTGKGERVSVGWFLEETSPYMWATLGIGFAVALSVVGAAMGIHTTGVSIVGGGVKAPRIKTKNLISVIFCEAVAIYGLITAIVLSGMLDSFKWSVVAANENVRNNNWMSGYVMFGAGTAVGLVNLFCGIAVGIVGSGAALADAANSALFVKILIVEIFGSAIGLFGLIVGIYMTSKVKMGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMR4</accession>
    <name>A0A084VMR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008772-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006608</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMR4"/>
    <dbReference type="STRING" id="74873.A0A084VMR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006608-RA">
        <property type="protein sequence ID" value="ASIC006608-PA"/>
        <property type="gene ID" value="ASIC006608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006608"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008314"/>
    <dbReference type="OMA" id="RDNTDVF"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="499" mass="51769" checksum="B377175B49458DF1" modified="2014-10-29" version="1">MSGFSFGTPTTSAPAFSFGTPAAATNTVPGAAAPAATAATAFSFGSAATATTTTATAAAGFSFGKPTTTTTTMAAPLSFGLGATASTASPFGTLNVPASTTAAATTTSTFAVPTLNFGATATGAGGLGSSTGGGLFGAAKTTSSGTTALAPATTTATTVGLGGVDINANLPKSVEGKNDSTKAKESQVPQEIINTVEHLKEYIKRQKTISSDIARSSARKMSNVSNEIKSLNCTLAELSNSVSNNQNAIKMLRHETSGITHQADMAQRTQETPAGLQFENTLPQQYFIELIQKYESDLINLKQQVELTEKHMNSLTTPQCFTPQDLKRCLKQIYESFVALAGRLHELHQKVETQKEQYLNLRRYLLRDNTDVFESHEGVKDGSKESDKFALNISSGPTPFSSVMGNVSFGVSLRQSATGTGTLWGSGAGAGGGSTEQHKNTFGQTNFFGMNPAGTSGTMGTDSLGFGNRLGFGFGSMSATGGDAFNLQKPPLGSKRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNF4</accession>
    <name>A0A084VNF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ribonuclease r</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006994</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006994-RA">
        <property type="protein sequence ID" value="ASIC006994-PA"/>
        <property type="gene ID" value="ASIC006994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006994"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7417" checksum="ED63506B966DC241" modified="2014-10-29" version="1">MEPEVQKGRVHPEPSRLPANFEQVVVNNKATHMVFGHIVSFQFDFCYSDALAQNFDGAFASVASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP27</accession>
    <name>A0A084VP27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007412</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007412-RA">
        <property type="protein sequence ID" value="ASIC007412-PA"/>
        <property type="gene ID" value="ASIC007412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007412"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007412-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="18366" checksum="EC2304ECE5223EAE" modified="2014-10-29" version="1">MNSIPKRPDAVDEDDEPHTKPSEAVGCTPFSWGGSGKRPPSPAWASYASYPSPGSGGAGGGSSLVENSAAAVYRNSNPAGRHPLTCVEKRPPANFPAHLSANPHGFPCPGRAAGSRRTGDDPIWRWWCISVARAQRPHTTKTDERLGCRDKNPVLMVERSVSRVWEGINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPC5</accession>
    <name>A0A084VPC5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009531-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007188</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPC5"/>
    <dbReference type="STRING" id="74873.A0A084VPC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007188-RA">
        <property type="protein sequence ID" value="ASIC007188-PA"/>
        <property type="gene ID" value="ASIC007188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007188"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018879"/>
    <dbReference type="OMA" id="YCCNCFD"/>
    <dbReference type="OrthoDB" id="8197893at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF98">
        <property type="entry name" value="TORN AND DIMINISHED RHABDOMERES, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="669" mass="72427" checksum="ABB43590500F048F" modified="2014-10-29" version="1">MANVLECVVSGTGSRWMLGTLILAHLIAYNEAGGPGSMIGMALAALYAAFAGACKSGVKSLQISYIRTTHRVDFFCLFLAKWMDILALFSACAVLVRTLSSSLDAMTGGLARMYILGRNSPANEPWPDVIGVVVIFIVTGMFMLGLENTRIFGLLMMSGVLLVGSLVVIMTGLRGNVSQFHSEPILPKGVVGLLSGTALSTFTYSNDLLNGNYIKRLLGLVVILLVLLSSELVCACLTVLIKFSSSHDYEAVPILSILELKDFHKLIPAVACLLVLTCSGALLELFPEMYTQIVQLTTSDWRILAKQIGYENRDSGSPTLTIFTGGSLCAMLAFACPLENLTYILAASNVLATLARSFHFLYLPFRPHYLEQSNESSLAYSRLNTGKSVGNSTVGNGLRSARKSFWCFKSSLAHQVLSGSRVVVSSHGNREEHEREWLLLGEPSSPKAPHSPQQSIESTVLSDQISDIECIALAKPENMDSEDSSTDIDAIVDEYRQKVTVSTAGYSSDGESLRLPTANSWYLAIIFIVLIVLGSVITASGLMLWETIMIVAGVNVVFIPAIILLLFPRYDQTNSSTPALMTCVITVLGSFILFSASFAQSWPALLLWFLAGLFLFIRCDTWCCLCLDRPGSGQTTLITSVSSTKTTTTIRVPRPPKGAIIQARIAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPJ6</accession>
    <name>A0A084VPJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP009487-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00007267</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VPJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007267-RA">
        <property type="protein sequence ID" value="ASIC007267-PA"/>
        <property type="gene ID" value="ASIC007267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007267"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015239"/>
    <dbReference type="OMA" id="HHSCLLV"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="6">
        <location>
            <begin position="456"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="7">
        <location>
            <begin position="650"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="913"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1304"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007267-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1348" mass="148911" checksum="B918EDE7EF07B409" modified="2014-10-29" version="1">MAHLDYEQHHYHHGCLLILVRGIGPSKPRSLQRVFERIQRVNNVKIPADSSGATRDIWVRYIRDHPVENNDWGDFQTHRRLLGLITVGKFDTQSELNELCRVHESLKVKYTHTLFDSRCLLFGPSTDELQKLPGSSTASEEAKGVGVAIEKCFQTPSNFKSRAFFYPENDSCSNLETKISEFITSIYYILELKRMEKTREKLEKAPLLLAPFEKKDFVGLDLESRNNKKRCIGRMTKHLGDLTLQAGLVAESLNFFHTASETLRAISDSLWLGAANEGLCAASAILLYPNFRYTMSIQRNSSLQENSSSPQKFNLARNQLYTGSYNGDSSTLKHKKSDMVINLNSTDTASIVTTDKTSASSNSSASSISSSLSSASGGSGSGASGNSSSDSGTLMNKGNGAVTPKYPANILQPDEITVRYRDAIINYSKYRNAGIIETEAALKAARICIEQGKNLDVAMFLQNVLYINLNMTEQQRVRRFEVLTDLYQKIGYNRKAAFCQRLAAWRHVAQSNSNPDWGQSYRLMLESFSGHKLSLEPNEVLENNMGWPVLQIDLLQQLVGTARRLGQSALATRHMTFLLQTMWKHLTPQEQKDMALQLQNLSSQCEGAPVPLVLENGIVIPPANLTDLPRCTQLLVKDLAPHQKPVKIIVHKVDSGPFLFTPIHFSSLDRRGQEKDDRVITFNWVQHDVCEVNLTLVNPLPFELQVTDMRLLTTGVVFEAFPQTVTLPPNAPTNVSLHGTSIECGELEVQGYSTHTLGVKSNCRLKHMQHRKDRHLPPCYRVKIIPALPKLETKTSLPQTATFSGMANADFVTTSASITLYNGERGECTITLTNTSNIAIEFVDATFHSSLEASLQGRIFQLDVDELNRKLPIQPNESIDFKLVINGEADFLGALTAGPGQIGGYAYSSGNPDGMNSAGPQSLTVSHGGGTGHGGPQMGMLSGGSGNPSIPSRISSPTNPHRRNELLTSSFRSSHSGHSSLATLSVGISTGHVPRQLDAQLRFKYSGGEGLQEGYCRQCAISFNVELLPSAQITNWDVLSAEIPSQFYLVLDVVNLTAQEMSLNYTSNKTILIEARESCRVPVPVQRCPLERIFAAVAEHQQQNQHLHHYPSHHQQTHSIGSTVTDHHLPSILSGVGGTSTSDSADLTERVCSEHISENVNLKWSLPGIDCHGTASLRGITLSPAMLDLVTVPPLEWEVKVDEQVVAPQSEVTCVTGQFLSFSISICNLSASVLHQVQLSVQFYQDYQNGVQNYRLETRLTMSGPNHVLIPSLNKDEKAFHKCSVLFFTPGRFKADIQCRSLSSTQQQQHQQRGDDAAPTMVVPPGSDSASHVWRFIPPIEITVADQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQA0</accession>
    <name>A0A084VQA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000642-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007680</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007680-RA">
        <property type="protein sequence ID" value="ASIC007680-PA"/>
        <property type="gene ID" value="ASIC007680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007680"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9673" checksum="F6B42F8498ABCC31" modified="2014-10-29" version="1">MENSCPPAFFPAIAEGPLLKNLYTQTAEEAFKPENAETQACLANLKKLACNKSKCEQATEVFTQCFGNTKLYSHLLDVFKAAATQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQC0</accession>
    <name>A0A084VQC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007703</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015183">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007703-RA">
        <property type="protein sequence ID" value="ASIC007703-PA"/>
        <property type="gene ID" value="ASIC007703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007703"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9921" checksum="B8CA1398B6AD068E" modified="2014-10-29" version="1">MFGKLDVDRSHVDVAVENAQSAHCSDIGPDGLRENKGKENNPNRLQQRLSLSEIRKEERNGGDIRFSCTERRLIDHRRNRTVMSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQD9</accession>
    <name>A0A084VQD9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006090-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007555</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQD9"/>
    <dbReference type="STRING" id="74873.A0A084VQD9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007555-RA">
        <property type="protein sequence ID" value="ASIC007555-PA"/>
        <property type="gene ID" value="ASIC007555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007555"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005892"/>
    <dbReference type="OMA" id="YFKQFGH"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="409" mass="45294" checksum="B1904C19382390B4" modified="2014-10-29" version="1">MAPKKENATIKSENTSTANNNIPAKKRPMKAKKVSPLTSGKLPLVKTNRRSPKPLRPYIGSKVIFIQHMPHGFFEEELAKFFTQFGDVKQVFVARSKRTGRSRGYGYVQFVYPEVARIAASAINNYYMFGRILKAQVVSQGFGDKVPRNLARSMDKDVAKRHAARLNRQVRNENGFFGDPRRQSRRLRQVEKVQKALGELKQAEIELPELPQCFVEVTRLVQHNADAKRTIKPATVKKEEDEENADSSDEEDAFVPLKPSDWVVMASESKTNDEDTAASQKTEKVEKAEESKSKPKKTVGGKEKKKTVGGKEQKKTGKKEILSKPAQKPSRKSLRTGTSKKKLLKKLLAAGWKIPSSAAASGGSAVISTSISAASRPYRCRHPTSDPTKLPTCAGVALYAAAAASIRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQJ7</accession>
    <name>A0A084VQJ7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00007620</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQJ7"/>
    <dbReference type="STRING" id="74873.A0A084VQJ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007620-RA">
        <property type="protein sequence ID" value="ASIC007620-PA"/>
        <property type="gene ID" value="ASIC007620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007620"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002524"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024427"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000002">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000002">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="20">
        <location>
            <begin position="531"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="253"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="760"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="852"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB40241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1201" mass="139770" checksum="AD5E20E72F7CD21C" modified="2014-10-29" version="1">MHIKQVIIQGFKSYREQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQALLHEGTGPRAMSAYVEIIFDNTDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRSEVVNLLESAGFSNSNPYYIVKQGKINQMATAPDSHRLKLLREVAGTRVYDERKEESMNLLRESEGKLEKISEYLRTIEDRLKTLEEEKEELSEYQKWDKARRTLEYIIHETELKDTRKQLEDLDVQRKSSGDKQKLLTQDIQKAQERVKAAQKALKDAKKDVVTAKDEKSVLATEHQQLLREKTKLDLTISDLSDEVQGDNKSKERAEQELERLKITIAEKEKELEQVRPRYEAMRRKEEECSRELNLKEQKRKELYAKQGRGSQFSSKEERDKWIQGELKSLNKQIKDKISHQNKLQEDLKKDITKHTELEKKILDHTETFEQLRVQIDEHNKHFYELKKRKDHHQTIRNDIWKKETAVTQTLSGYKEELAKTDQALRSMAGKPILNGRDSVRKVLESFQQRGGQLADIANAYYGPVIENFNCDKSIYTAVEVTAGNRLFHHIVESDRVGTQILKEMNKQKLPGEVTFMPLNRLQVKIHDYPEDPDSIPMISKLKYEEQYDKALRYIFGKTLICRNLERATELAKSTGLDCVTLEGDQVSSKGSLTGGYFNTSRSRLEMQKKRSEYLQLIQDNERELSDYRAELKQTEASINSIVSEMQKTETKQGKSKDAFEKIQADIRLMKDELTRIERFRSPKERSLAQCKANLEAMNSTKDGLENELHQELMSQLSVQDQHEVDSLNDEIRRLNQENKEAFTSRMSLEVTKNKLENLLTNNLFRRKDELVQALQEISVEDRKRQLTNCRNEVVSAEKRIKKVLSDTEEIDRKLNEAMKQQKTLQKELETWIQKEKEAQERLEEDSKRMEKWATKENLLHQKIEECTEKIAGLGALPNVDASYQKMSLKALFRELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYTRKAELDVGKDKICELMQLLEARKVEAIQFTFRQVAANFTEVFKKLVPQGTGHLILRTTTDQEGNDMERNVETSDEFTGIGIRVSFTGLDAEMREMNQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRSAVADMIHELSDKAQFITTTFRPELMEKAHKFYGVRFRNKVSHVDCVSKEVARDFVDDDTTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRA1</accession>
    <name>A0A084VRA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SURF6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008004</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Diptera</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Nucleus</location>
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        <text evidence="2">Belongs to the SURF6 family.</text>
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    <sequence length="292" mass="34014" checksum="EFC06C59D85302FC" modified="2014-10-29" version="1">MGRKVASELQTRLQTINDEIEFYLELFRIPESKKEDIDIEEFLLNTDKEVKPVRFGANKPADTAEELSARVEVMKNKITAKSKARKGKQTTDSGKIERKKLKKEQTLKQKLLKIGMMTAKKEEQRAKMLDHKPLAVKQEKKLAPTFNPEGKIVFSKFQLDENDKPKKGIETDKKKLLRKVIENKKHLTELKESGDLEKYAEVKKQQAWEKAMAKTTGQKVRDNPELLAKKLDQRKKQKKKSKTLWKERAAKIEQQKAQRQKERQANIKERVDKKQTKKLQKLAKKGRVIPGF</sequence>
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<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zou P."/>
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                <person name="Wang W."/>
                <person name="Lv Y."/>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1303"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1539"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2103" mass="225200" checksum="01233EE809940C58" modified="2014-10-29" version="1">MDFIGNLLNQMSSAFNQETAIPKKEEISMDETLKWRALKNNQFASRTRGGAAAAAAAVVVGAPTVGGTRSASSIGRSRSAGGRISQGGTSNGQQKQLDQRASSENSNDSSIGGEGGGGGGGGGGPLVDGLLEGLAANGEETDAPEEDIEIEIAKDISGEELQEALALSQLLEVDPMEVGTMEQEGPGAPEVKKDQKGEPVADSKDTLIREDETKMDTKMVETGQGELVAGDEKARSTNDAADEEKKINQKRQNEDKKAEEAQQKEPKESSSTNTGNDREEVGDDRDKKLPSNGVSIPATSSGNDASTDRTPSTEPGDKTIDGAIDDVEDDDDDVLIISTGEMVDVVEVAETSKEDEDDDEVLEELQKDLEGGEGSAAEVAKKQQPTVVEETEEKYHPNVGESNGNKTASALEQQEAKFSPTSKADQSPNDEKKAEEKPPLSRKDKSPKRDGSEASVKEDHVADADVTTKGGASLPGPVAVGGRTTRSKKAVGSVGTTSSSPSPATPAATPLQRRSQRFQGKEADAEGRKSGDVKLNGDRETVAVVVVKEEEPDEGKKKPAIAGTTAATVKGTGKTPTVAPTSVERRSDRSLRSRQQSTSSGSGTVGAGGQPATVVTRRSSETTKSVAPSESDANEPTETVADRGMLRRGRKRLSHDPAPTVELVASSRDKTARVPTPAAKEEDDPPVVSSTEPGFPLDPGENDSGGAQVEQVQQEQPPAPPPPPPPPPSQSQQVAPAAGAAQQQRRGRKRKQPNAPEPSGGSTSGASSSSPEKPPPYKRAARVSRDGSDGILASALARRDKVDPQGRLSRPIKLSAKMLANEELRHGFEQHNNGRIIIGSDTSTSVGGHVDEPVVVVVDREKVDRERAVPQDDKPRKRQSEMQQEIQRPKEPLVNLPPSNSAISSSSEDVMVVSVTYPTPKAGSSGKGSQNLSSFGRKPTDSSTERQRTTKPVSGAQPKKASSTTTNACPDVQTFLQEIRTSRICINRSPEENRKLNRSQTKRLAKQKEKHMMALGLQRKGTVQPPAVVRNGVAATRRSPAEEDEELLLSEPEPESESSGSEADFVPSQKIGTVGKPSVTLRLRKPETMQEGPAPSTSKPRNPQPPLVTVPSAMVRGSVVASGRQQQQQQVAVPRQQGASKQPQTNNSRMPANAPNSRRSVVLPAAMTTATTTQVRSSSSTAQSAAAAQRKDKETEQLQRSLERFGCELTLIPTNSTPSAAASEGRSTASSIAQTNRKRTKEQRTPPVRSNHLAQVSSSSSSSAASAAASTAHGTTSPSLQIVLEKRPQSSAAAGGKNHHRTATTPSSSIGSPPGSATAGAGSRPLLCLCRQMSDIFVASSVGTGYCTAVDDIDGQMIGCCNELSDELVHMLRPSPTVSFQLLCNLHRKRLEDHSCCAICGVYCTQGNFAMCKNAHIFHPDCAVKYVLNAPFDPARPTERTAPTLVLQCPHCAQECPNGEIQVTVQLTTPPVLLPSRKNIVKPAMMAIGKSNKGTANGGSTAKDAFRANVDSFVPSRVRNMLTTGGKGAATNGHDPRRASPSGAGSGSGTASKSHYSTKSIFEAIHSDNVDRITEIIISGFDIETRFRDFHDGTCLHLVSNFGSIGMAYLIICRAQSVDFLNILDRELRTALMCAVLGAKLDIVKLLLECGADVTVKGPDGMTVLHLAAKLGQHEAVRMILEWGRKRLTARDLLAFVNGVDNGAYTALVWAAENRYKETIQLLLSSGADVNICDKENNTALHWAAMAGCSDSMHLLLKKGCDPNVQNINGDTPLHLACRHGFGEICIMLLTMGASLNVRNASDELPQDMLQNPNSECASIIAANVKMFSLGKNTKETRILCSDISNGREYYPVQVVHTAGRNDRQQTIPTFKYIQKSVQLECRIDTNLSDMTVCTCKDSCTSADSSCLCSERTWYTEDGRLVNDFDFLQPPTIVECGDLCDCNQQLCRNRVVQRGLRVPLQLFYSPGKAWGVRTLVPIPKGTFLVEYVGELLTDDVANQRPDDTYFFDLNSGFCIDANAYGNVSRFFNHSCDPNVSPVSVFYEHQDKRFPKVAMFACRDIKAQEEICFNYGERFWAVKNSTMSCLCKSSACRYRTVQQQAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS64</accession>
    <name>A0A084VS64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Two component system sensor histidine kinase, GAF region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008242</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008242-RA">
        <property type="protein sequence ID" value="ASIC008242-PA"/>
        <property type="gene ID" value="ASIC008242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008242"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008242-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="163" mass="18513" checksum="C338C14C7B75CF54" modified="2014-10-29" version="1">MAHLWDYPSQYQTRRQTRHSSHGRNVKFNEASLIRIISTGIARAFRPPARCTVKFNARDGQLKPVETSLQLGEWLLDSASETSMFQPRTNTEPVPTQRRVEENDINGGVSSNFPVQASEPCGSFELAGVWRKQDRRYLETPLSCALEMGGISKNCCFFCFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VS71</accession>
    <name>A0A084VS71_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01015825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015826">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VS71"/>
    <dbReference type="STRING" id="74873.A0A084VS71"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008250-RA">
        <property type="protein sequence ID" value="ASIC008250-PA"/>
        <property type="gene ID" value="ASIC008250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008250"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018405"/>
    <dbReference type="OMA" id="WYYGLIR"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="323" mass="37427" checksum="D88304266DB81072" modified="2014-10-29" version="1">MAQSRELPSDNSCRRSDSVFDRLAKKNPNYQDKIKVIEGDLEKPNFDLCPESMEYLREHTNVILHIAATVKFDEEMIKAITINLGGTRTALEIGRQAKNLQSFVYVSTAYSNSYDEYIQERVYPVDCNPEKILANLDDEKLIQDVIKYSHKWPNTYTFTKALAETLTLEYRQHFPIAILRPSCVMSSLNEPMPGWCDSIFGTNGTFIGWYYGLIRTSHIDPDVTIDTVPVDYVSNAIIAVGWKTYIQRMSPVDLQLYPCDNRNYTWRLFFEVAVPGLKKYFFKEDLNNVRQARLAMRKKELIVNTVLFAFVGLILLQLYYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSG4</accession>
    <name>A0A084VSG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013171-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525048">
        <property type="protein sequence ID" value="KFB40908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSG4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008439-RA">
        <property type="protein sequence ID" value="ASIC008439-PA"/>
        <property type="gene ID" value="ASIC008439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008439"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023359"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="377" mass="35742" checksum="3634E32B2DDA141A" modified="2014-10-29" version="1">MGDFLYSSSVLANESCVTNPSLLDTLSINNLLNIKHLTTGGADIGAGSGVSDSLGTIGESSSSSSSVSGLGERSKNNNASTISKMASGGGGGLSLGPNGTDVDGQGLLMTSSVAASSCGVGGLSSVSSIITTAMSSEGCSLSLALGSGGGGGADHDGTVTSSLLNGGSITSPSIGVNLGNANGNNNSTGHSHSNNGSSSSNGSNANGNGNGAGGAGGNPNNANNNLLLDSAADQLQLQSVAEELSLKASDLGCLSVTSNLMNGSSHIGSCLAPSGLGFGATPDHSSPWSTGPDEAGQGGTAGGHLSMNGLGGTSSAQFPNKAGSLSLSSGGGSGSSGGGGGGGMGGMGGMGGGFPGPLDMDENRDPFLSSYQVSDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSM4</accession>
    <name>A0A084VSM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP008650-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008607</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSM4"/>
    <dbReference type="STRING" id="74873.A0A084VSM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008607-RA">
        <property type="protein sequence ID" value="ASIC008607-PA"/>
        <property type="gene ID" value="ASIC008607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008607"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012061"/>
    <dbReference type="OMA" id="YNADGRR"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000211">
        <property type="entry name" value="synaptotagmin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF373">
        <property type="entry name" value="MIP05618P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="169"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="304"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008607-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="456" mass="50232" checksum="4F4A2E7A28827503" modified="2014-10-29" version="1">MKSPISWFNQPDSAVNATQIAIYGSVSFLVVSLLGVLIYISCSKRYRLNWFEKNLLESAKEREAALRHSQDGQISCPIAYNVDAVAGTSRYLNRASGSPQAKADTPPFWASQGLYRKSDSRGQLIDTSDEETTGEESGDSACSSGRSVIAAPSGAVAIASTGKHVVLVSASPAKPTTSTSLAGGPSSSNGKPPKGAQDLQPQDFSGTADPYTKIRLLPDRNNMWQTRIHKKTLNPVFDEDFVFEVRSATIGRRTLEILLFDFDAYSRHVCIGGVQFPLAQVCLAEKIDIWRPLLPYTEQDNKQDLGDLMVSLSYVPSAEKLTVVIIKARNLRVIDGTRNSSDPYVKVCLYNADGRRIKKRKTTVARNTTAPVYNEALSFDISRETLKDCSIEFQVLHDSLLGRNETLGRATVGNGPEFRPENRKFFDELFRTRAATAQWISLSELKQKSTASTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSV6</accession>
    <name>A0A084VSV6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00008671</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01016142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSV6"/>
    <dbReference type="STRING" id="74873.A0A084VSV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008671-RA">
        <property type="protein sequence ID" value="ASIC008671-PA"/>
        <property type="gene ID" value="ASIC008671"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008671"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019064"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008671-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="630" mass="69763" checksum="F9CD679777B29A42" modified="2014-10-29" version="1">MLSGFQRTKIHNSAGHLAEEIEYDEIPVSRIRNFSIIAHVDHGKSTLADRLLEITGTIAKHAGNKQVLDSLQVEKERGITVKAQTASIVYKRAGENYLLNLIDTPGHVDFSNEVSRSLAACNGVILLVDANQGVQAQTVANYHLARSKNLVIVPVLNKIDLKNARPEAVCNELLTLFDIDPEEVLKVSAKLGTGCDQVLSSIIDRLPPPDANRDAPFRALIFDSWFDKYRGALNLIYVKDGEVCTGQEIVLCHTGRSYEVKSLALLRPDERKVERLVAGQVGLLGCNMRTSKESQIGDTVYLKRDKGCVPLPGFKPQQPMVFAGVYPPDQTQHPVLKGAIEKLVLNDSAVTVTPDSSPALGQGWRLGFLGLLHLDVFSQRLQQEYDAEPVLTAPSVTYKIKLKGAKAIAAHGGNETVFISNPALLPDPTFVEEYHEPYVLGTIIAPTECVGPIIGLCVERRAVQKTSLNIDNERIMTTYLMPLNEIVLDFHDQLKSLSSGYASFDYEDYGYVETSIVRMDVLLNGQLVEELCTITHSSKAQNHARELVLKLKELIPRQMVQIAIQAVVGGKILARETIKAYRKDVTAKLYGGDVTRRMKLLKQQSEGKKKMRSIANINVPRDTFIKVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT60</accession>
    <name>A0A084VT60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007032-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008709</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016196">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525061">
        <property type="protein sequence ID" value="KFB41154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT60"/>
    <dbReference type="STRING" id="74873.A0A084VT60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008709-RA">
        <property type="protein sequence ID" value="ASIC008709-PA"/>
        <property type="gene ID" value="ASIC008709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008709"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003715"/>
    <dbReference type="OMA" id="MEWEAVE"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04495">
        <property type="entry name" value="BRCA2DBD_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="5">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="3">
        <location>
            <begin position="119"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB3" evidence="4">
        <location>
            <begin position="475"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008709-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="711" mass="80259" checksum="FD1C9DC34C4C87AD" modified="2014-10-29" version="1">MDNVMAFRFSMIDYYGEALCNSNTTGIPIGSDGEAILLMDQHSTVGVEEMRLCFLASLGIDPRLVPSGWVENGWRWIVTKLSALERNLNDHFTGSLTPENVFHQLQYRYHIEIDCARRPPLKKVLEKDDIASRRMVLFVSNVFPIDGTMVDRELELSDGWYAVRTVIDSPLAAAVREGKITIGTKLMIQGGELLNHKDGCSPLEVPPEVRLKIHTNATRRVRWPVKLGYYRCPVPFLTPCSAIVDRGGLICRLRAIVVRVYPLVYVEKSSSESHGSVLRSERMQQRHSRRNDASQLDSLHKLYNQIQQEIESERRTAANTLNRNVRVTESTPCSQLQELLEGGLDVSFLDMELTLSQQAVIQRFQQQRQEELQQEINRRVKSQMDKRSGRSSVTSLLKVRLMDRVKPDRAFVLSIWRPSDDVRFVMQEQNYLEATNITANGCKNNDVQLTAHKSSTYTKLPIPGDVSNELLRFNRAITPIASIDALSFRPAFSEFDTIGVVVHVGSVDSKKFQSIYLADTAMELLCVNFWHGLAEYAYDDVVHERAILCVANLQWRTIGRQNQAIPQSFATEYTTFTEKPRSGQQRAEWDRFQLQLDAIDGDEFFQRCQEKVRELKDTLGSIGTPTANGNFSTPNAQRSMSRMLHAQHSTPLGTGTGGSMVQRKIETLATIYGSPPKLSPIVIRSNPILRKGFKTPARLDEGHSGSPASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV43</accession>
    <name>A0A084VV43_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009677</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV43"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009677-RA">
        <property type="protein sequence ID" value="ASIC009677-PA"/>
        <property type="gene ID" value="ASIC009677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009677"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784071" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009677-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8709" checksum="F3873D0CFCA52AB6" modified="2014-10-29" version="1">MQKVHALQVWILLGFVSGSLLLCDGENSELAKLVDQTEPLVNQVLIEATVAILVNNYVHYGGKQLYFSWDVSDASLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV45</accession>
    <name>A0A084VV45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lig_chan-Glu_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009680</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV45"/>
    <dbReference type="STRING" id="74873.A0A084VV45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009680-RA">
        <property type="protein sequence ID" value="ASIC009680-PA"/>
        <property type="gene ID" value="ASIC009680"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009680"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002851"/>
    <dbReference type="OMA" id="SCADMSP"/>
    <dbReference type="OrthoDB" id="7739311at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056198">
        <property type="entry name" value="LBD_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24061">
        <property type="entry name" value="LBD_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784132" evidence="13">
        <location>
            <begin position="25"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009680-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="525" mass="58690" checksum="3689F58C9CBDF202" modified="2014-10-29" version="1">MQDTRPAAFVWLVWALVCVADVHALTPTLATITLRRSPLSDVVGIILHTHFQQPYSTTLVMVRSQTEDGRRSLHDLVSLLLMDYVRGQLVIQFEGAHDANQSWQRPWSHILLLAEGYDALRLVYGQLTLKLYDFAGYYLIVLVGIDTTLATIDRIFNDLWQRQIVNVIVAFRMPPPANSVQLWTYFPYSPGLCRVPKPHLVLTWPNDTLLYGVNFFPRKNANFHGCPLKVGTFETRPFTILTGTPGLGLGLSGFEGDLLDSIAAKLRFSVNLRIPPHSQQWGVAAFENSTGMMRMIYSEEVDFGIGCLGVSSERSAMLKPGKVHFTTELVVVVPPGRPYTPIEKLFQPYSPLLWGAIFSYLGLGILAIITSQRRPLLRRYLIGRGVHAPSLNILRLLFGNPLPRTPTGNFPRTLLVFWVQLCFVLQIAYQGSLFKFLQRASRHPPMATLADIDRSGAHYHITESARRFFEPFPINLAAFGTSHPAQTVSLRGYAGSVPTRTTRMLPCAPGTMWRTTTGQIVAGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVQ2</accession>
    <name>A0A084VVQ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009628</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009628-RA">
        <property type="protein sequence ID" value="ASIC009628-PA"/>
        <property type="gene ID" value="ASIC009628"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009628"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009628-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8853" checksum="6E9F3430865B6A80" modified="2014-10-29" version="1">MNRSLGGCMLLGVYRSPRFLHPQRMVGKTGPATIRGQDSGAEFREKVSMRDFLSLARAHPGNEASERQENLATEPPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW01</accession>
    <name>A0A084VW01_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Apyrase</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009808</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01017363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW01"/>
    <dbReference type="STRING" id="74873.A0A084VW01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009808-RA">
        <property type="protein sequence ID" value="ASIC009808-PA"/>
        <property type="gene ID" value="ASIC009808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009808"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017359"/>
    <dbReference type="OMA" id="AWEYAQV"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000001">
        <property type="entry name" value="NT5E isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783856" description="Apyrase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="34"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="14">
        <location>
            <begin position="347"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009808-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="615" mass="66778" checksum="810A94ADF59B8EF8" modified="2014-10-29" version="1">MSAKASIIPLMLLILAMANRAISAPKAAGLELIVLHNNDMHARFEQTGAYSNDCQPSDVASNRCYGGFARVAHKVREYRATEASGGLPVLYLNAGDTYTGTPWFAVFKDNITTAFLNMLKPDAISLGNHEFDLGVDGLVPFLNEVDFPVLVANLDLSSTPTMQNTKSLRRSIVFTKSGVQIGVIGYLTPETKQLTPVNTVEFMDEIEAINKEAATLKEQGVNIIIALGHSGLERDKEIAAGCPEVDLVIGGHSHTFLYSGPAPDVDEPAAPYPVMVKNAAGKEVPVVQAYAYTKYLGYLHLQFDAEGNLVELDGSPILLNGTVQRDSDVLQLLEVYRPGILELDEQIGHTNVFLDSSRCRFEECNIGNMIADSLVIIHAATRTNADDGNWTDAAIGFVQGGGIRASLNAGTITKKDLKTVLPFGNGMVLTELSGAKLRQMLEHSVYRYDGVSGYGEFLQMAGVHVVYDLSRPPLERVVDVEVRCARCNVPTYGPLQDDAQYRVLVSQFLYEGGDGYTMFADSEREQLAYGEYEITEEYLKRYSPIYPAIEWRIRLEGQPQPPPSETTTVGPEGTTGAVETTTEAGGGAGSLLSLTISSLGMILLAALPTSVRFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWN7</accession>
    <name>A0A084VWN7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01017674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010073-RA">
        <property type="protein sequence ID" value="ASIC010073-PA"/>
        <property type="gene ID" value="ASIC010073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010073"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006593"/>
    <dbReference type="OMA" id="AIIAQCC"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02429">
        <property type="entry name" value="PTH2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13192" checksum="66076797446E7BE8" modified="2014-10-29" version="1">MAATKLVQYVVVNGEIAKSWPKGAIIAQCCHAVAAVSHLYASDPDTQEYFNDLDNMHKVVLEAPDAAKLVGLGEVLRQNDVKHKVWIEQPENLPTCIALKPYPKETVQKYMKKFKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX60</accession>
    <name>A0A084VX60_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010265</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01017849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX60"/>
    <dbReference type="STRING" id="74873.A0A084VX60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010265-RA">
        <property type="protein sequence ID" value="ASIC010265-PA"/>
        <property type="gene ID" value="ASIC010265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010265"/>
    <dbReference type="OMA" id="VLQTKWP"/>
    <dbReference type="OrthoDB" id="9981542at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="549" mass="59432" checksum="18B64EC18A98548E" modified="2014-10-29" version="1">MGEHLASQSMVVPPTTGIEQTAGPGSSGMTGDNSAGSSSSSDSNTSGAGGKRMVSKEFFTLLWGSKIKQDVFRRWLQGFSFSEHEPSALVQRDGGPCCVIAPVQAYLLKILLMETPGHTLGDLTADKCKTLLIQAVCQILTKCKTDAYRIVTLESASATSASSSSSSSSKEHTTSEVAGEEQSADAVATSAGLGPDVAPVECVGYDVPDAAMVRPAEEAAAAASASSSSSSGAGGGGGGGAGRSQDCRLTPEEFHSRIGFREFNSVDDVQQFYMQNFHILTDECGVLLLLYTVLQTKGLEAILSEMSDPSESLIHDTYGCGSQALINLMLTGRAVPHVWDNEQDVGGMKLKGINQQSDIGFITVMEQLQYCTVGFFYKNPKNPVWVMGSDTHLTVLFSNEKRLVSPETPSEVARRVFRQFDADGSNFIPSPMLQDVLCALDLVSEPEYVDLMRSRLDPENLGIILLNAFMNEFFPNEKKSTPDTFDLLHYNGIPHSNLHNRVLYNRGHAVLLESDMRMYNSSDPMLTCLQTKWHNIEVSWNGDRTPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZI1</accession>
    <name>A0A084VZI1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011217</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZI1"/>
    <dbReference type="STRING" id="74873.A0A084VZI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011217-RA">
        <property type="protein sequence ID" value="ASIC011217-PA"/>
        <property type="gene ID" value="ASIC011217"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011217"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015499"/>
    <dbReference type="OMA" id="YNCAACE"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011217-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="13229" checksum="9E7690540E5C2F3A" modified="2014-10-29" version="1">MGKIFVDHIGGQKLYNCAACETNLTNKRELISTRFTGATGRAYLFKRVVNITYSQVQDRIMLTGRHMVRDVMCKNCKAKLGWMYEFATEETQKYKEGRVILEHALITESEGFPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZW0</accession>
    <name>A0A084VZW0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011315</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525258">
        <property type="protein sequence ID" value="KFB43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZW0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011315-RA">
        <property type="protein sequence ID" value="ASIC011315-PA"/>
        <property type="gene ID" value="ASIC011315"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011315"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011315-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12445" checksum="710AD31EC0AA5C4B" modified="2014-10-29" version="1">MPSVHQRNVRKPYHGTLSDPSSISIGERKICKSIGKRTVVRAQDVPRHSGIESAGTLEKMDVGLCWEHQDGVSTGHCPHAPPLLAEEVKASVPCPHYYIRSLAFSSPGGYNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZZ7</accession>
    <name>A0A084VZZ7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AGAP002816-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00011353</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019059">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB43541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084VZZ7"/>
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        <property type="protein sequence ID" value="ASIC011353-PA"/>
        <property type="gene ID" value="ASIC011353"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC011353"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004002"/>
    <dbReference type="OMA" id="NENCFTR"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Ero1"/>
    </dbReference>
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        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ERO1-like"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
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            <begin position="411"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB43541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="489" mass="56636" checksum="0FCECB6B89D51B8A" modified="2014-10-29" version="1">MAPRRRLFDRQPARLEFQWVVISFVVLLSLANRSSGYFYSGGDEESNNDQFCFCQLQGTIDDCSCNVDTVDYYNNVKIYPRLKSLLVKDFFRYYKVHLNKDCPFWVDDSKCAMRFCHVEHCEEKDIPPGLKGDTGSYHKYIKEVQTLTNCNEDLDVELGYLNTSISDKAHKEFQRWADYDEAQDNFCILDDHEPGAEYVDLLLNPERYTGYRGESARRIWSSIYLENCFQAHSIKKKNAFSAMIPYQDMAHNEVCLEHRVFYRMISGLHSSINIHLCANYLLSEKSSLGFVAPSGVWGPNMEEFERRFSPHMTDNEGSHWLRNLYFAYLVEMRALAKAAPYLRNEEYFTGLEKDDREVKTAVKDLLTVIEGFPSHFNETAMFSGGTSSIKLKHEFREKFMNISKIMDCVGCDKCRLWGKLQVQGMGTALKILFSGKFDDKVDSDGLGTKLKPQSPPLRLKRGEIVALFNAFGRLSTSIHELEEFRQRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0G7</accession>
    <name>A0A084W0G7_ANOSI</name>
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        <submittedName>
            <fullName evidence="6">AGAP001175-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011443</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="gene ID" value="ASIC011443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011443"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB43711.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6892" checksum="F14140623D828CCC" modified="2014-10-29" version="1">MFWIVWYKFVVEDPDVLKANVGWCVGLHILLHYLMLVNYFWMFCEGLHLHLVLVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0H4</accession>
    <name>A0A084W0H4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001169-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011451</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0H4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011451-RA">
        <property type="protein sequence ID" value="ASIC011451-PA"/>
        <property type="gene ID" value="ASIC011451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011451"/>
    <dbReference type="OrthoDB" id="7743230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011451-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="17719" checksum="761F5DC1FC7B4CA3" modified="2014-10-29" version="1">MVVKMILVDFLIGFPMYAVYMWYERDTGLVFLSSFTFNTVAVMQLVATTNIVQFALIWGNCLYRLINERIQHLVSSIRQMDDSVEYWNGSNAEQRYIFRHIWRHLNILRGQHYTLTESIRDMARFYNLPLALIMSNQFVIIISEVSKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0V6</accession>
    <name>A0A084W0V6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00011699</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0V6"/>
    <dbReference type="STRING" id="74873.A0A084W0V6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011699-RA">
        <property type="protein sequence ID" value="ASIC011699-PA"/>
        <property type="gene ID" value="ASIC011699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011699"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006010"/>
    <dbReference type="OMA" id="DKMYELF"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="348"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB43850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="580" mass="63255" checksum="A90BAD89A6ED5AE3" modified="2014-10-29" version="1">MALNDKYIHRTENDQPSEAIALSNLDESDSRPRGEDKHSRIRRYGTITAINGTVAVFFAFATHRYIYHEKDCTTNCGMQWCDGYGMLVLLLAFVYSGLLYFLFLKPRIGSTVSRLLAPPKSTLSNMFHKKMTKAIVGAIVLLGFALFLYFDSRHDASRLMSLTGMVVLLALSFLCSKHPKRINYRPVFIGLLVQALLGLFCIRWDVGRSIFACIGAKVDTFLHYSSIGASFVYGDALINKYAVFAFSVLSVIYFFSFFISILYYVGAMQWFVLKLGWILQSIMGTTVCESIMAASNIFLGMSESPLMIKPYVKDLTHSELHVIMASGFATVSGTVLAAYISFGASPGHLITASVISAPAVLCVSKIIYPEVEESKTSTENIQMEETTDTSIVDAACNGANAATSLILGIIANLIAFVSFVAFINGLLGWLGMLVGVEEVSLEWFCGYIFRPLAFVMGVSWKDSEHVGKIIGIKTVVNEFVAYQQLGALMKNQTITSRSSTIATYAICGFANPSSLGIMIGALSAMAPSRRSAITSVSFRSFIAGSIACFMTACIAGLLIDDSQSMAMQQRALGATANLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W197</accession>
    <name>A0A084W197_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Multivesicular body subunit 12A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ESCRT-I complex subunit MVB12A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein FAM125A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011819</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MVB12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W197"/>
    <dbReference type="STRING" id="74873.A0A084W197"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011819-RA">
        <property type="protein sequence ID" value="ASIC011819-PA"/>
        <property type="gene ID" value="ASIC011819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011819"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004108"/>
    <dbReference type="OMA" id="QTTRYLC"/>
    <dbReference type="OrthoDB" id="6021306at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032510">
        <property type="term" value="P:endosome to lysosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032801">
        <property type="term" value="P:receptor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019075">
        <property type="term" value="P:virus maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.100.10.50:FF:000002">
        <property type="entry name" value="Multivesicular body subunit 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040335">
        <property type="entry name" value="MVB12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018798">
        <property type="entry name" value="MVB12A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31612">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31612:SF2">
        <property type="entry name" value="MULTIVESICULAR BODY SUBUNIT 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10240">
        <property type="entry name" value="DUF2464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MABP" evidence="15">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="UMA" evidence="14">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="299" mass="34027" checksum="6EAA9FBF19D6F11E" modified="2014-10-29" version="1">MMKSTTQQQKNILNTVIGALPDNRPITSLQLVEEYEKCPPNFQPINKTYDQDQDADLWREKMLIGKRTTRYLCQSKTEGLPDYIVETLRIINDKEVTPDGFSQLTRTADTEQKAWRKKQIVYRLTKKGSAKQAVTDIILCSRLRQAPEGFTLAGDLNGILVCFKTCPIPHRPPPSVPSKQTITELEKTIENLKLQANPTNNNSSESQDYEYVQLRPSYQLSPKRAAPRPPMYSTGTLNIHTDVEGVPFVLNPALKHNNTALPVFYNAISVNMEYDFQLERQVLCTTKTSNSQNTNPFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3A6</accession>
    <name>A0A084W3A6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">DNA methylase N-4/N-6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012592</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525284">
        <property type="protein sequence ID" value="KFB44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3A6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012592-RA">
        <property type="protein sequence ID" value="ASIC012592-PA"/>
        <property type="gene ID" value="ASIC012592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012592"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15099" checksum="98B34F4D86FD3343" modified="2014-10-29" version="1">MYPFVIATVASDWKLVKPSTAPFATTIRGDSIARALKQGGATITHRYESCFRQANENENSWYCILLQQQHVRNNGRRFLAVCYTVLRSPNRTRIVGDSVLSENKSHILKEAKAAAVFVSPEVGQSKAEASSAGVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4K7</accession>
    <name>A0A084W4K7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4K7"/>
    <dbReference type="STRING" id="74873.A0A084W4K7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013106-RA">
        <property type="protein sequence ID" value="ASIC013106-PA"/>
        <property type="gene ID" value="ASIC013106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013106"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001129"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020914"/>
    <dbReference type="OMA" id="FCENPSE"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000159">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000929">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="441" mass="47561" checksum="16B49AFFB1E8857A" modified="2014-10-29" version="1">MREKDHSPRKMLPSPKQGAVYPLLGLGSTLPAPFDLSLVNRSSSSNLLHQQQQHQQSLAEQPLDLRVEHKKSSNASGGGGGTSTTASSDDEGTDPPRASSTDSKPSSNFRISNLANHSPSALFPPPGLNPLMLEAIAKAGLPLPYRGSFLPPRSPVSYDLQRLKEREALAASLSQLRQSATNGGGGGGGGGGGGGGGGNNVLNNNNANIINHNLPPGAGGPGVHGKNKDRYACKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCALCERCFGQQTNLDRHLKKHEADAAGLGLGLDERLRAARRNSRGIPEDSYFEEIRSFMGKVTQLPIPLRLQQQQQPSSQTHQSNSGADSPFGRRHQAHQDLQNDTHSSRSSTPSDDEPVSPAASIGSHPAEEDIKMETNNNEDGDEPLQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W514</accession>
    <name>A0A084W514_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001520-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">CBM21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W514"/>
    <dbReference type="STRING" id="74873.A0A084W514"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013254-RA">
        <property type="protein sequence ID" value="ASIC013254-PA"/>
        <property type="gene ID" value="ASIC013254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013254"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014452"/>
    <dbReference type="OMA" id="GWKTHED"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF48">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="205"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013254-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="376" mass="41167" checksum="3DAF3DB85CA6B9EB" modified="2014-10-29" version="1">MPAFAEMLVSQSPPVYSHSLPTTDYKSGSGSPGSPGGGNDSAASYFANMGSYCRPASLQLTTTPQSNGPPPFQRQLTPPWGLSPTGGKGPASPRRSCLVVRPDEPTTPEEPEPPITADMTPSTDAATTTTFAGEIPVKSKKKVVFADDHGRQLTHVRIMSEPSYMPPIWSLQFLAHVTQGMISPVPQEQWVVDFVQPASDYVRFRQKLDERNVSLENVIIKETEQLIVGTVKVKNLSYHKEVIIRSSCDSWKTHEDTFCTYSVVGNGAVSAYLLYDTFAFKLTLPPKSRRIEFCAAYKCDGVEYWDNNDGRNYSLTNRIAPREDSGAFLSSAAAYSSGRNGTTTATGGFRSPYVDSSAPLDTWTDMNVESQTGPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5D9</accession>
    <name>A0A084W5D9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP013463-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00013365</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020591">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5D9"/>
    <dbReference type="STRING" id="74873.A0A084W5D9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013365-RA">
        <property type="protein sequence ID" value="ASIC013365-PA"/>
        <property type="gene ID" value="ASIC013365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013365"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007596"/>
    <dbReference type="OrthoDB" id="7784786at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB45433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013365-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="331" mass="36941" checksum="2F320A7EB974DC07" modified="2014-10-29" version="1">MLSAVEFTVLLATIPRLSFCTHMVMLKRVAKNFIQCLFLYSMILVGFAISFYTLFRGPNGNGGANRNNNATDPEESNPFNEFGMLSMALLKTTVMMTGEFEAAELKLHQSWGYYVLFGLFLFFVPVVLYNLMNGLAVNDASTIQKQSELIAIRQKVFVINSCERTLKAFNRVRNIWNRCFDGQPGEMMENFEYICISPNTGNNILVPSKVVSDNIANTDEIELREVTVVNEITSAADLTAVQRAPGNGKAPVPEEPILSDLPGRMDDTVVMNAYGILCSNGEDSINQDLKVQQSIYNLSQEIATMNKLLTAKRQHELPQLNPIHQANKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6C6</accession>
    <name>A0A084W6C6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013745</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6C6"/>
    <dbReference type="STRING" id="74873.A0A084W6C6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013745-RA">
        <property type="protein sequence ID" value="ASIC013745-PA"/>
        <property type="gene ID" value="ASIC013745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018618"/>
    <dbReference type="OMA" id="TRYTPDM"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784267" description="Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="52034" checksum="54AAB667ACD8C5E9" modified="2014-10-29" version="1">MSVFALMKKLGILNFIVVQVELETLDKLTVWTKNQFTHREDHFLSDHRPVAQLFPDKLHDLNGYQFVLYGEWDYPYIMPYVDGVYGVLPKFFDIIIHQRCNGTTSYSQNAKHSHLVDSRFNRMDHRLSFEHTLYFREQSGWYLVCPERKERDFLQPLLKPFSMGIWIVIAALFVTCWMLQFLFPMTYRYDLVGITFFGGGGTEYEHPFQFRIVTFTLIVLLFFLSEAYNTKLISLMTFSKFYKQPETLEEFARSDYRILAVPSSLEMSLGLKHNFLSLSETRREERRLGPRKNEVYCSIMNQGIAFSVVGIGLENYAVPLYMIREPVIVDRSLVQFNRHSPFYDMFQMYFDRFNDAGLWINLIDRCMHALGKVRPHLQGSEQFQEVIFYFNDLTCIWILVIAGWLVSGITFVFELIWWKFHYKFGTRNAKSEQFRISLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6U5</accession>
    <name>A0A084W6U5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013904</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020953">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525310">
        <property type="protein sequence ID" value="KFB45939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6U5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013904-RA">
        <property type="protein sequence ID" value="ASIC013904-PA"/>
        <property type="gene ID" value="ASIC013904"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013904"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017344"/>
    <dbReference type="OMA" id="MWHITFF"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000028">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="271"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013904-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135995" checksum="CCC95FCD36CFFA51" modified="2014-10-29" version="1">MTCGISCVDNALNRSFYKLGLFIGRHPGYFLIVPVLLALLCMTGYQQIKYEIDPEYLFSPIRGEGKSERAIVESYFKVNYTHRFNVGRITRPGRFGRVIVISKDESNKNLLRSEVWQELRLLDGIIQNATVQYDGETFTYREACARWENECFTNDILNLDKIIDEVEAGDLNLTFPVMFNPVTWDAHVFPVFFGGTQVSEDNIIISVPSLQLVYFVTADSKRQDARGAAWEEAFLEAVGYAEDNGVFKHISVARFASRTLDHELERNTRTVIPYFSSTFVLMILFSVVTCMMGDVVRSKPWLGLMGNISAVMATCAAFGLAMYLGIEFIGINLAAPFLMIGIGIDDTFVMLAAWRRTSVKLSVPERMGHMMSEAAVSITITSLTDMISFWIGILSPFPSVQIFCAYSGFAVCFTYLWHITFFAGCMAVSGHCEFKNLHAIFGYKVLPESVAIKEKRSWLYRKLNTGGINRDDPDNPIDNKEHALMAFFRETMARILNKGWTKTIILVIFAAYLGGACFGLTKIKEGLERRKLSKADSYSVKFFDLEDEYYREFPYRIQVIVTGDQNYSDPHTQMQIEELMQSLENTSYVTSPLYSESWLRSFISYVDRNNDYLNLTLDSEQAFIDALREIWLFPANPFSLDVKFNEAGTKILASRFMIQAVNITDTNHEKVMVKDLRQICKDSPLNATVFHPYFVFFDQFELVRPTSIQSMIVGALIMMLISFIFIPNFLCSLWVAFSIISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKARTPDERVREALYSLGMPIVQGSTSTILGVVALLLADSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCTSNYHPDDDHKLSAVEKSYPHPYCISHPQLALTGAFGSKNFLGAPYKAYGEDKDLGIGTSGEDSSESSSSKSQRRQAIEDENTRRRYEEGWRRSTHNLTGQSQFQPMLDLYGQEALWTKTASKVPPLKVANGRYGYDDMLLNVAQGQTTTATRKQRSADLEHDRPEDHRRDRRRSAEDERYKSRYEDNRTFVDDEMLDDTDYQHTNRYYVYDTSHVKRLSNDSSAAGSSNSGHPHNHNAGGGHHAGAQGGGPSSDQHNNPVVANRRKFSDESDNRGRRHSDERRPRKFSPPEGIYKQNPHRSSSQHNLYYPRQPPQRTASQSSLHQLRHMGDMRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W732</accession>
    <name>A0A084W732_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013996</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W732"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013996-RA">
        <property type="protein sequence ID" value="ASIC013996-PA"/>
        <property type="gene ID" value="ASIC013996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013996"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="13152" checksum="ABCA2FF0D72746CC" modified="2014-10-29" version="1">MYKKSDSFPILSSPDLYQNRSIHLTVATALVRSPPFHWLKTPCLGEMSFRRWKSGRRPRSIDLPDMGRWAIRSPESSSVVIAATMHHAKGGVSFRQIDFRKPQTRTRCQPWIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8F1</accession>
    <name>A0A084W8F1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP012577-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014485</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021421">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8F1"/>
    <dbReference type="STRING" id="74873.A0A084W8F1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014485-RA">
        <property type="protein sequence ID" value="ASIC014485-PA"/>
        <property type="gene ID" value="ASIC014485"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014485"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003729"/>
    <dbReference type="OMA" id="KAFHHFK"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005390968" evidence="7">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014485-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="547" mass="62010" checksum="E631A25D2018C4F5" modified="2014-10-29" version="1">MKFLLLVLSCLAASALATKPPKWPEVYAVSGVLTIPYAEINEPFYAWYDKKNGRSRIDYYGGMVKTYQLTKQGDFGVSLKLAPVSTKDQMNKETCLQVNGTTDNAIEVQGILPYVKDFTLLGTEECSGYQCDMFGLTEVIGQKRNVYKLWVRYVKSPKYPAARMPIPVRYEMKGYNTLLGSHYDHYYLDYDSYDHEDIPEDVFEVKLSDPCVGFPGPGNGHYATFNPMQEFIHPRSEEHLHDEFGRFKNKHKKSYVNELEHEKRLNVFRQNLRFIHSHNRANRGFSVAVNHLTDRTEDEIKALRGFRSSGVNNGGRPFPYDPKDYLDDLPDTWDWRISGAVTPVKDQSVCGSCWSFGTIGHIEGAYFRKTQKLVRFSQQALIDCSWGYGNNGCDGGEDFRAYQWMMEVGGVPMEDEYGGYLGQDGYCHVQNMTLYAPITGWVNVTSGDADAFKVALFKHGPLSIAIDAGHKSFSFYSNGVYYEPECKNNLDGLDHAVLAVGYGKLNGQDYWLIKNSWSNHWGNDGYALMAVKDNNCGLTTDATYVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9K8</accession>
    <name>A0A084W9K8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00014910</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="ATLV01021831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9K8"/>
    <dbReference type="STRING" id="74873.A0A084W9K8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014910-RA">
        <property type="protein sequence ID" value="ASIC014910-PA"/>
        <property type="gene ID" value="ASIC014910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014910"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007186"/>
    <dbReference type="OMA" id="FMDTINP"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000084">
        <property type="entry name" value="AGAP005119-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000040">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="141"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="545"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014910-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="834" mass="93287" checksum="21EA9563726E799F" modified="2014-10-29" version="1">MAEPNQNIICAPEDCAIKISKWKVREGYPVTSGNIILFYEVLDGGDKEVKRLKATKSGVVKKRLAREGATVAKGKPVLELGQCSHTTVIKDMCADCGADLRQDEPGSCSKASVPMIHSVPELKVTETLAKKLGQADTERLLSDRKLVLLVDLDQTLIHTTNDNVPNNLKDVYHFQLYGTNSPWYHTRLRPGALDFLAKMHPYYELHICTFGARNYAHTIAQFLDKDGNFFSHRILSRDECFNATSKTDNLKALFPCGDSMVCIIDDREDVWNMASNLIQVKPYHFFRHTGDINAPPGMSKNELDGKGVDFKELMNQSMKEKKSKEAPTGEDSRPPTPKIQTDDSKQKEEKSATDETSAAEGKATEPTEGSKEAEEKSEKIPTATTVDETNSETAVATKEEPTNEESGSNEKKESVEESTESNALDSHSDGVVVDANEQEDEAETPSNIVAENDNGANKEAKENAEELKVQPAETEAEKKKENSTTVQRKTKSNDSQEKKELIEIEDPDDYLLYLEHILLKIHETFYSEYDRSKAISDLKQLIPRVKAKVLVGTRLCFSGLIPNNVKLEQSKAYQIARGLGAVVTQNLEPTTTHLVAVTIGTSKVNNARKNSKINIVTPEWLWTCAERWEHVEERLYPLKASNPAKMRQPPPHCHSPEHVVNYGGGTTKSREEPKFMDTVNPLLSFSNDDLDAMNNDFDDFFESDDSSSGDEPVDIENPPMEKAMRKRKRAEEIETNRGRHNIFRKRTEEEEQAENARILKFNNAEQDEASQTNASSDDEDESPSAKFRRGEDLPSDLDMGSNSEGSDEPIDDVDDGDWNMMGAALEREFLGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9P1</accession>
    <name>A0A084W9P1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004805-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014947</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021849">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9P1"/>
    <dbReference type="STRING" id="74873.A0A084W9P1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014947-RA">
        <property type="protein sequence ID" value="ASIC014947-PA"/>
        <property type="gene ID" value="ASIC014947"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014947"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016086"/>
    <dbReference type="OMA" id="MMPGFSP"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="83"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="655"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="447"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="941"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014947-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129230" checksum="10630A37AD4883BA" modified="2014-10-29" version="1">MGLASSKAVNSIAVSSHGGAEMGNGRLSKDSVIVETSSSYPSADIQQQPCSILPSPSGSSGIDTWKSSSCHVRQASIRSRNLQPMPDAGELDRRFAKVLASMDLPPDKAKLLKNYDNEKKWDIICDQEMVQAKDPPAHYLTKLRTYLDPKASRSHRKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDENQGLDALIDYLSFRLAMMRHEQRIQEAKSESDEGLNPKETSGINSSYGSNEANHRLVSNGFMRPGLGDMMDSPSIKRRSRHIAKLNMGLTTDDIHVCIMCMRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILFAFDNFKKVCSEQRRFQTLMEYFMNYELFNIDFMVACMQFVNIVVHSVEDMNYRVHLQYEFTALGLDEYLEKLRLTESEELQVQISAYLDNVFDVAALMEDSETKTAALERVNELEDELGRALDQASEIEREALFKIGELEAELSRTRCERDELYNKQLAVEDEVAKLKRALKQHEQESQNRKSMLLELENLTKTLPKGTSIADVSNLLAKGGLSELSPTNGGNGGGQQQQAPPIPPPPAPPIPSAGAPMPPPPPCPPGSGLPNGGANEPPKAPPKPPTFIPVPPPMGGPPGFHNALHCTDGAMTIKRKVQPKYKLPTLNWVALKPNQVRGTIFNELDDEKLHRQIDFVDFEERFKIGMGGPLTNGNCDMDGLTAFPSKRFKKPEHISLLEHTRLRNIAISRRKLEMPIETVIKAINNLDLKLLSLENVELLQKMTPTDQEQKMYKEYVIEKKDLNQLTEEDKFMLQLTKVERISSKLSIMNYIGNFFDSLHLISPQVYSIISASSSIKSSKKFRAVLEVILAFGNYLNSSKRGPAYGFKLQSLDTLLDTKSNDKRMSLMHYIVATIRLKFPELMNFDTELFCIDKAAQVSLEMLISDMSELEKGMEAVRKEVDLRGKGTQSHVLRDFLANSEEKLKKIKSECKTAQESFKECIEYFGESSRNADANAFFSLLVRFVRAFKTCDQENEQRRRLEAAALQASTKKDEEEQVVMRNNKINSQKKQQEAVINELKLKAHAVREKKLLQQDEVYNGALEDILMGLKNEPYRRADAVRRSQRRRIDSNRLSRTMEEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Q3</accession>
    <name>A0A084W9Q3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP004797-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Q3"/>
    <dbReference type="STRING" id="74873.A0A084W9Q3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014960-RA">
        <property type="protein sequence ID" value="ASIC014960-PA"/>
        <property type="gene ID" value="ASIC014960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014960"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005282"/>
    <dbReference type="OMA" id="ERGNDCM"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF532">
        <property type="entry name" value="HEAT SHOCK PROTEIN STI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014960-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="23710" checksum="BB0B97B905F98BEE" modified="2014-10-29" version="1">MVGIRRCSCTQSTAANGKAAAPEKDGGKSNLNLTADELKEEGNKCVKAGNYTEAILHYTHAIKLSPSDAILYSNRSLAFCKMQQYYYANEDADKAIALNPTWAKGYFRKAEVSMGVGQYDTALLSYGKALQLQPQDMGIIQAARKAAALSNADRRDEKRSPLIGTGIGCVVGLCIVLADMLLTEKPAIKTFKSPKKKMKDPVTSGPSEIDIQKLKQGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAX9</accession>
    <name>A0A084WAX9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein KIAA0284-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015618</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAX9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015618-RA">
        <property type="protein sequence ID" value="ASIC015618-PA"/>
        <property type="gene ID" value="ASIC015618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015618"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8822" checksum="589E99B7ACF6D8C7" modified="2014-10-29" version="1">MVKQIVAALSAYEREQSAIEPLEGGVGKNIVVEMGVTSVDGLVAPNPTPIGTVKRSRLLRSPEEAIAANKKPKSGRKKKEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB07</accession>
    <name>A0A084WB07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015649</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015649-RA">
        <property type="protein sequence ID" value="ASIC015649-PA"/>
        <property type="gene ID" value="ASIC015649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015649"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015649-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="16141" checksum="F19A8F383A668A46" modified="2014-10-29" version="1">MEESASLDGLRPTCLMDVHSTYRSVDSAQHAIAGSYFIPGGDEGELSPTYDRQYQTPGHKEERTSGVWQILASKSAEPFRRFGRLSSRVQELVCFLVARNSDSSIDLAIRSLEETLPWRRFRANGFLIHKTIEVYRMVDGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBF8</accession>
    <name>A0A084WBF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP012607-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00015516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015516-RA">
        <property type="protein sequence ID" value="ASIC015516-PA"/>
        <property type="gene ID" value="ASIC015516"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015516"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003267"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015516-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11491" checksum="1973D391F8934B90" modified="2014-10-29" version="1">MSLYSGILFGVALGAGAWLNSLQEPIPIVQLAILAALIMVMLYRYWSTRAFMPAGMIILLSFGVVVWTCVIYRDYLAVGWMRGAPYSDHNFTVVIVDENSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDG2</accession>
    <name>A0A084WDG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00016379</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01023007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDG2"/>
    <dbReference type="STRING" id="74873.A0A084WDG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016379-RA">
        <property type="protein sequence ID" value="ASIC016379-PA"/>
        <property type="gene ID" value="ASIC016379"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016379"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014793"/>
    <dbReference type="OMA" id="FVECDIH"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024448">
        <property type="entry name" value="XylT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12529">
        <property type="entry name" value="Xylo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Xylosyltransferase C-terminal" evidence="20">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016379-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="253" mass="29012" checksum="F334AD8F0E40B4FB" modified="2014-10-29" version="1">MPSWQPDFIINLSESDFPVKSVSKLTDFLTANKGRNFLLQQKVLPLQKYISSTGLDTNFVECSGRMWSIGKRSLPVGITYQGGSDWFCLSREFAQYVVNTNDDLVGDLHALMKYTGFGTEVFFHTLLYNSRFCQTHYDSNLKLVSWKLGHGCIDNSQTIDWVGCSPVVIRDEDWSQLMLRVSNDDIFLARKFNPIFDQMIILKLEEKILGKYPPNTPNLNSYWENVYHHHDPDPKNNTSGLIRIAYALTIQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEB7</accession>
    <name>A0A084WEB7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016873</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016873-RA">
        <property type="protein sequence ID" value="ASIC016873-PA"/>
        <property type="gene ID" value="ASIC016873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016873"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="20772" checksum="DF09B82D1C6DE8D6" modified="2014-10-29" version="1">MQEPRVLRRPITDGHVVQNGNEREAIQSFPVPEESSVCSRIIHDAVRHESINGLGTGAEPKVGACVLLGLFPIANGFPPSRRAVPFGHMFGRMLLPLEITRPPRLASSVGAHIVANGVQCGLGVIQIARRLGGSDFPPDATGYVSTARVLPQSIRLCNAASRTNVGLNPSGKYDPYLLLVRRGHATQVMLQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEE5</accession>
    <name>A0A084WEE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP007084-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00016575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEE5"/>
    <dbReference type="STRING" id="74873.A0A084WEE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016575-RA">
        <property type="protein sequence ID" value="ASIC016575-PA"/>
        <property type="gene ID" value="ASIC016575"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016575"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018311"/>
    <dbReference type="OMA" id="FGACNCM"/>
    <dbReference type="OrthoDB" id="6628406at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF247">
        <property type="entry name" value="PICKPOCKET 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016575-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="473" mass="55142" checksum="3A324166C37C731F" modified="2014-10-29" version="1">MAYRLTFTKAIQSVLSRTSLHGVFHLVHARSTYFEKVLWFGFITMALTGGCYTVGIFWLRYWTNPTVIALDRDYHLWNTTFPSLTVCFQKRLNERARDELIERIDPELAPRYAEFLDTLLDSDIENVGRLAEFDEFEGVNLRELLNELTDRPNAIIAMEGDLQGTLVRTLTEMGICYTFNSALTRYLSIDPYTGEEKLYQVSVFNGEASATISNCTSNANIYFHSPYEMPTIRKSLLLERGFFTFTKMDFNALAITSDPALKYLSIKQRKCRFPHESNLRFFPEYYSYGLCLLECKFYLFLKHCDCVPYFYQIADRSKYCKLTQLACVELYQSYISFLTADELREIFGACNCMKNCDDVTFTLQQYGSTFWFNDPVIKWSIRIPKIRYSRRIIYAFIDALVSTGSILEFFFGFSIITLIEVGYFSLRSLVVSCLRSKSTQTFCRRQRPKENRAKNKQVLVSKPIVEEKQIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEF6</accession>
    <name>A0A084WEF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016587</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023209">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016587-RA">
        <property type="protein sequence ID" value="ASIC016587-PA"/>
        <property type="gene ID" value="ASIC016587"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016587"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="188" mass="20824" checksum="29FEF4BBF8206917" modified="2014-10-29" version="1">MNKLEQVWARASPPHSDLTASPVRIDYADDRVFRCRSWKSDSNELAVIWQQGVHLLALVERSLCCVGTCVRHAIGPREVRTRVAAYQRGIPWSLVIRRPSRRHYIFVPVAARARNVPKAAAAARNGMQAAVGCRSRSIHHGAKAEAPRETLTKGPDRNPLTRPDAIRAAGDVTVADCSIFHHSTHGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFF2</accession>
    <name>A0A084WFF2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000859-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016946</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016946-RA">
        <property type="protein sequence ID" value="ASIC016946-PA"/>
        <property type="gene ID" value="ASIC016946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016946"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019672"/>
    <dbReference type="OrthoDB" id="5950649at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018445">
        <property type="term" value="F:prothoracicotrophic hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052876">
        <property type="entry name" value="Insect_Hormone_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940:SF1">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016946-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="307" mass="35213" checksum="DBCCE9AE8D8B26CE" modified="2014-10-29" version="1">MHFIEEVEVKLNAPGTQSLVDQKTEERSGKQKAANRKLQQEGELQVSTPDVPPWDWRVFVQLIVCGVLFVLILAPTDCKLKYTEVLHGNRPESLLLRSVNSAKRLDLQREDPATSDSSARLQSNGDRREQDADRDEVNRSGESSEDLSVSCFPPVDLFHKYDWAQYQLRHLPERSWVQDHTQTIDGETSARSSVKRSDYNRELSADLYAQYPSSCACQTKYELLDLGYTHFPRYIVNAICQNRSANSRKCWRGSSCKEIPYKVRVLTRRSANESSDQDHHSTLLPEPLREYWRFKTVTIAAACQCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG16</accession>
    <name>A0A084WG16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009270-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023429">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG16"/>
    <dbReference type="STRING" id="74873.A0A084WG16"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017317-RA">
        <property type="protein sequence ID" value="ASIC017317-PA"/>
        <property type="gene ID" value="ASIC017317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017317"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009169"/>
    <dbReference type="OMA" id="CKYMPHG"/>
    <dbReference type="OrthoDB" id="6419989at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF8">
        <property type="entry name" value="BEATEN PATH IA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017317-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14857" checksum="771B698F9024F786" modified="2014-10-29" version="1">MSLCLRNVRVTVPTAVRKGDSAQLFCYYELEDKERLYSIKWYKGKREFYRYTPQENPSMKVFNLDVERTLSNQSHVVIKAHETNVSGKYSCEVSADAPSFHTMIVSGDMEVIGKRFHRKLLRLASSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGH1</accession>
    <name>A0A084WGH1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sialin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">H(+)/nitrate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">H(+)/sialic acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vesicular excitatory amino acid transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">ZHAS_00017432</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="28 30" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71539"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:72592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:72599"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:72600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:28989"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGH1"/>
    <dbReference type="STRING" id="74873.A0A084WGH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017432-RA">
        <property type="protein sequence ID" value="ASIC017432-PA"/>
        <property type="gene ID" value="ASIC017432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017432"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003690"/>
    <dbReference type="OMA" id="CGFAVNH"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF455">
        <property type="entry name" value="GH23975P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="27">
        <location>
            <begin position="27"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KFB49315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017432-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="487" mass="53961" checksum="7FD11FA7630DC0B0" modified="2014-10-29" version="1">MDASESNKLSDGIEAPMWMFWKRRRYVLVFLAFFGFFNVYSLRVNLSVAIVAMTENRTIEHPNGTVSYEQEFDWDSSTKGYILSSFFYGYIFTQLAGGYISNALGGNYVFGVGVGTTAALTLLTPLAAHGGYGWLIAIRALEGFFEGVTFPCMHAIWSNWAPPSERSRMATIAFSGVFTGTVASMLLSGVLADTLGWEWVFYILGAFGCLWFVVWMVVVKKSPETDPYITTKEKEFILATQQRESSDTAEKVYHPWMAIVTSKAVWALIVASFAENWGFYTLLTQLPTFLKDTMHFELQAAGFLSALPYLALGSLLSFAGYLADLCQIKRWLTTTQVRRYFNCGAFLVQTVFMLIGAFILRPGPTIACITIAVGCGSFAWCGFAVNHLDLSPKSAGVLMGISNTFSTVAGILTPIVSGQITANGSDDEWRTVFYIAAGIYLIGCVIYWFGVSGELQPWSIEAQEREQAQREKENVYVNAGMVLDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHM5</accession>
    <name>A0A084WHM5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018371</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHM5"/>
    <dbReference type="STRING" id="74873.A0A084WHM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018371-RA">
        <property type="protein sequence ID" value="ASIC018371-PA"/>
        <property type="gene ID" value="ASIC018371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018371"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001626"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002228"/>
    <dbReference type="OMA" id="VVEHDEC"/>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784741" description="Phenoloxidase-activating factor 2" evidence="8">
        <location>
            <begin position="20"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="109"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="450"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="715" mass="78978" checksum="8DE8B17EC191C1B5" modified="2014-10-29" version="1">MFQQTVVLFALVASMGCMGEPQRSTCDGTCVPYYKCKDNTILEDGSNIINIRFGDDSEEDRECPSPFEICCEKPIVLLEPPPSVTTTTSPPVPGPKCGYRNTKGLGFLITGNKNGESEYGEFPWMLAVLREDRKANDSGNVYECGASLIASNVGLTAAHCLHNRQKDLLLIRAGEWDTQTRHELYPHQDRRVAEIITHEQFNKGSLANDVALLILTEPFVLAPNVQPICLPPKEYSFDLSKCFASGWGKNNFGKEDNYQVILKKVELPVVANEQCQKSLRETRLGKRFILHPSFMCAGGVAGQDMCRGDGGSPLVCPISGAPGYYYQAGIVAWGIGCGEEGIPGVYGNVQYFREWIDNALTCDGTCVPYYMCKDNLVIEDGTNIIDIRVGEDPEAGPECPHYLDVCCEKADLLLEPPPSSPTTTSPSVPVPDQPSPRCGYRNTEGLGFRIAGHRNGESEYGEFPWMLAILREDRKADNSVNVYECGASLITLNVVLTAAHYMFNKTKDQLLIRAGEWDTQTRNELYPHQDRRVAEIITHKQFNKGSLANDVALLILTEPFVLAPNVQPICLPPKGYSFDLSKCFASGWGKNIFGKEGKYQVILKKVELPVVANKQCQKLLRETRLGKRFILHPSFMCAGGVAGQDMCRGDGGSPLVCPISGAPGYYYQAGIVAWGIGCGEEGIPGVYVSMQYFREWIDNALINRGILTHEYVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHQ1</accession>
    <name>A0A084WHQ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018402</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHQ1"/>
    <dbReference type="STRING" id="74873.A0A084WHQ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018402-RA">
        <property type="protein sequence ID" value="ASIC018402-PA"/>
        <property type="gene ID" value="ASIC018402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018402"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008925"/>
    <dbReference type="OMA" id="PWLVSIW"/>
    <dbReference type="OrthoDB" id="7468414at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784973" evidence="2">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="168"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="438" mass="47920" checksum="961B0E3288842478" modified="2014-10-29" version="1">MNHLERTIVWLVLVTFVLSLSRGALGCSCVPEALCPAPDVDLRLVDSAEECPLGSVCCDVPVGEPSVKDNEISTDLFCDGECVPINGGSASDEYDEYGTDLIDIRLVADTRCPTGFTCRSEPPTKAPVCKGTCVPKSMCTMFKMDTQNGGCTGGDVCCSMDRTSWMGLINGINEMEFNQSSKTTAQEERCVWRTESDGIRIPPWLVSIWARMEIVPGLTTDQFVCAGALLDPQYVLTLASCVKDLTVEDLFVNIGDYDLASRSSLRMSNIYSIREKTIHEDYDPPLIRNAALLKLADQVRKSNCNVTLAPTKDNGHESMKCHIVGWNRELLAVKNAGLPRQYKTRVESFNEDLFCAPGTICLHPEGTECESSALTGSPVICDENKPTSEGWSLKGLLVGNCTGVTVDNLGPWVEHQQTPGFVQLPKPTDPSRQYLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI02</accession>
    <name>A0A084WI02_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Macoilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00017868</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI02"/>
    <dbReference type="STRING" id="74873.A0A084WI02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017868-RA">
        <property type="protein sequence ID" value="ASIC017868-PA"/>
        <property type="gene ID" value="ASIC017868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017868"/>
    <dbReference type="OMA" id="KQRTACE"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF6">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="96132" checksum="B578730D1D642406" modified="2014-10-29" version="1">MKRRNADCGKIRRPIKKNKIAEQIGSNTLLYFKFLLLWVSVITADFLLEFRFEFLWPFWLLLRSVYDSFKYKGLAFSVLFVCIAITSDLVCLFFIPVQWLFFAASTYVWVQYVWHTDKGICLPTIILWILFVYLEAAIRWKDSRNIPHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRIRQRKQREVAKDNDFYMQLLQEALPKEESILLDPAVTDGTVNGGGKMNGSGGSYSYHQAVAVQQGSGIAATSTTTTTNTTSNNQNTANGITNSTKDHGGSGGSNHLGGGAGGKEPKDGSGGGVPTETVPHGAGSAVGSGKSSAGKQNGHVLNHEVVNSESGTPAPNEAKSGGRSGRKNRLKKAAEQNQANLSAIAKLCATLALASSVSTLTTSTATSTGGGVGDTTTLTTAATGTTSSPSSSSSSTKDNHQHNNGEQTKGGNMTADGGSSTNQHGPSSGSNKAMGGGGGGLSGQQQQPAVTTTVVVQKVCESCPRLEVDLKKVRAELATHRQTENELRQKYDSTTGNLKACLQAKQKDYDELQSRYQELSNQRQQERQSLQTVERRLGEERRHRQSLEAQLNNERKHRKQAEEKAARAECGEACKMKKEQMELEIDKLQHDLLATEDAKHMAEKQARNYEQEMRKMEVQMRNREAQQNTEVLMSALAAMQDKNATLEKNLSAETRVKLDLFSALGGTRREVEILTCSLRSKEKEILDLNAKIVQLVAVMPTLTNEALCLGGPGSGTGSDGVPGASMMRLADAPQLLPQQPMAGGPLNGVGGNQGGGGQQPSPMAHRVLNGPPMMSQLGSLGVLTSSMTTLPSVSSVLAGQNSGPPPGSVGVSLASLASGSGNSSVGGGGGNSQIVQMQSSNGAPNGGNNCPSNLDPNATVYTPKNNGMVGGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIB2</accession>
    <name>A0A084WIB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Pmp22 peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00017992</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIB2"/>
    <dbReference type="STRING" id="74873.A0A084WIB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017992-RA">
        <property type="protein sequence ID" value="ASIC017992-PA"/>
        <property type="gene ID" value="ASIC017992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017992"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004533"/>
    <dbReference type="OMA" id="CAPTMIG"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF81">
        <property type="entry name" value="GH12661P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="28100" checksum="99519DCA583761B9" modified="2014-10-29" version="1">MLSRTVVCRSFFYGQQRCRGQAPWLRVAFSSKAPSPDPSKLEPSTVRRIWRLMFGRYLLVTNTVSSGVLMMLGDIAAQEIEMRRDHAVPSTGYDWRRVFNMTLVGISQGPLHHYLYKWMDVLLPGASVRTVFKKIGIDQFVISPIFIITYLYSAGLLEGASFTTCTDEIKNKYWTIYMADWLVWPPTQFINFYLLSPKYRVLYINGITMLYNVFLCYIKHNDDLVSLITGGAGGDAGEKKKTAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK73</accession>
    <name>A0A084WK73_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018940</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK73"/>
    <dbReference type="STRING" id="74873.A0A084WK73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018940-RA">
        <property type="protein sequence ID" value="ASIC018940-PA"/>
        <property type="gene ID" value="ASIC018940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000966"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="467" mass="51768" checksum="A077554DF183D215" modified="2014-10-29" version="1">MSDAKDRMEVAEDQNIEDAILARASDDEDMDDDEEAGGEKVKAKVYLPGHNISPEEELVCDESAYIMLHSASTGAPCLSFDIVQDPLGEDREDFPMTAFVVSGTQAARTHVNSVIVMKMSNLTRTSKAKSGGGDDDDDDEDEEDSDDEDVGGMGEDPHLDCALIKHAGCVNRLRVTTFNSIQYVATWSEMGKVHIYNINEQLAAVEDKQACRTYQDGKVGDGIKPVFTFAGHQKEGFAMDWCTTTRGMLATGDCRRDIHIWRPNDKGSWTVDQRPLIGHTDSVEDIQWSPNEANVLASCSVDKSIRIWDCRAAPSKACMLTAANVHESDVNVISWNRNEPLIASGGDDGVLHIWDLRQFQAKTPVATFKHHTDHITTVEWHPKESTVLASGGDDDQIALWDLSVEKDEDVEDAVTNDDPRLNDLPPQLLFIHQGQKEIKELHWHPQLKGVILSTAHSGFNIFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLJ1</accession>
    <name>A0A084WLJ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006733-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019141</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLJ1"/>
    <dbReference type="STRING" id="74873.A0A084WLJ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019141-RA">
        <property type="protein sequence ID" value="ASIC019141-PA"/>
        <property type="gene ID" value="ASIC019141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019141"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13056" checksum="27734518F433976A" modified="2014-10-29" version="1">MVDKIEMSLDEIIKSQKSSRGPRGGGRAGGAGRPSRRPASGASSRNGFRSNQQRNGAVGSGGGGVLKGRNRGGISRARFGRPYRDELELTQGVLGQLPAAFPKSSPDGRPKQRQGCCGFPFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLN3</accession>
    <name>A0A084WLN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019188</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019188-RA">
        <property type="protein sequence ID" value="ASIC019188-PA"/>
        <property type="gene ID" value="ASIC019188"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019188"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019188-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="175" mass="19629" checksum="DCA206CDD6AAF29C" modified="2014-10-29" version="1">MCVLWMHSAAAKHSLPFDVCVRFSLAAVQSHRQVFPFPMANQLHPPFGKNKWPDIIHNITAAECKRAAVGMSAINNRKTSKAHTNARQSCVCVVATSTARPERAGRMDRRVVGAEAQPYEVRKIKRFSHFRLSITGATSAAARSDYFISPPGKEKDRRRGLRRKSAVWRCGQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMV5</accession>
    <name>A0A084WMV5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019615</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMV5"/>
    <dbReference type="STRING" id="74873.A0A084WMV5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019615-RA">
        <property type="protein sequence ID" value="ASIC019615-PA"/>
        <property type="gene ID" value="ASIC019615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019615"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019391"/>
    <dbReference type="OMA" id="NQAGGTH"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="25660" checksum="B1354AA9FEBDF808" modified="2014-10-29" version="1">MSIKSSNSVDSRTELADLIKRKAEISETLANLERQIYAFEGSYLEDTQLYGNIIRGWDRYLTTNKTTNSKADKRNRKFKEAERLFSKSSITSMAAVSGLVDTTDTKHERNSESDSMTNDDSSDNQVSSLTTVNHSASTTTTTASAGRELGASGAHDGALKNSVSKTLGNQSKANVDKSSASSSSFLNRATTPTKETNSTTSIAKESPASGTPSNTAKHKASSSIGSMKKGSSNKKVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN99</accession>
    <name>A0A084WN99_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nori-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TP53-regulating kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">p53-related protein kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00019779</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN99"/>
    <dbReference type="STRING" id="74873.A0A084WN99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019779-RA">
        <property type="protein sequence ID" value="ASIC019779-PA"/>
        <property type="gene ID" value="ASIC019779"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019779"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013299"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019779-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="235" mass="26636" checksum="50E143D4DEC7ABD7" modified="2014-10-29" version="1">MGGENEGKVQEKLLKQGAEGKLYIGTYKDKQCLVKERFEKKYRHPALDRQLTRQRIKAEQKAFQRCATAGVVTPALYGVDLEQRKIYMEYLDKAKTAKDFIDELTGSPGAEESPQLKKLAEQIGQMVGVLHKNNIVHGDLTTSNMLLDPVDTEETLPYRLVTIDFGLSHSSDNTENKGVDLYVLERAILSAHSQLPKLFGMILKTYCEHNTNRCDETIAKYEEVRARGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNX6</accession>
    <name>A0A084WNX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP013112-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00020083</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SERBP1-HABP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024772">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNX6"/>
    <dbReference type="STRING" id="74873.A0A084WNX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020083-RA">
        <property type="protein sequence ID" value="ASIC020083-PA"/>
        <property type="gene ID" value="ASIC020083"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020083"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000649"/>
    <dbReference type="OMA" id="EEMNGFQ"/>
    <dbReference type="OrthoDB" id="6022699at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032381">
        <property type="entry name" value="IHABP4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16174">
        <property type="entry name" value="IHABP4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="207"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB51920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020083-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="507" mass="52953" checksum="21202CEC9FB66427" modified="2014-10-29" version="1">MENTSYGINVANRYDLFCIDDDAGDPMEAILKNKQKQQKKQQPAANAGAAAAAAGTPAAAGAPQSQQPSSGQAKSAAAKGGEKENKSAGGRGAENRHPDKTAAQTNGTGNLHNQRGTERRGIKETQKDNIRNQENQKAGPGAAGAKFPRGPNNKNGTVAPGGGNDDKYPRKPREYDSDGQRKPYAQNGGGAGGAGGAGGPKRFDGRGKRDFDRQSGSNKTGIKAVDKRDGAGSHNWGSSKQDAKEYSNLDQEYQPQDADTSADEKTNPERTNNVANGGEGDGAADAAAIAKAEEEAKEMTLDEWKAQKAAVRLKPQYNLRKAGEGEDSAQWDKMVALDRKSAKGEGAEGDDDENNDTQKASAGGKSKQVLEIEFHFNDNRRGGLGRSRGGRGGKGGGRGMGRDGPGGRGGRGGDFGGDNYRSGGGDYGYQQDGGAGGTNEGGMERPQRDNIRRNNRPPLGGAGAGGPERSYDGGMNKYSRPNPRASKQPNTPAAPKVDDEHAFPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNZ3</accession>
    <name>A0A084WNZ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004258-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525361">
        <property type="protein sequence ID" value="KFB51937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNZ3"/>
    <dbReference type="STRING" id="74873.A0A084WNZ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020143-RA">
        <property type="protein sequence ID" value="ASIC020143-PA"/>
        <property type="gene ID" value="ASIC020143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020143"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001075"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020143-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17566" checksum="38E56DBE63DE6CE3" modified="2014-10-29" version="1">MAGPHLEESTVTTPSITGGVVVNTASLSLSRPTNLESSICTIDDFLAHFKHKELENDVSKYLSHKQRPLCRRVLAYLRTAWMGAKFTSKSDCELEEIVSPPKYRPESIAALCEATRFTEAEIKRIYRGFKAECPAGIIREETFKFIYSQFFPQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ57</accession>
    <name>A0A084WQ57_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP011566-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00020567</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025253">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525378">
        <property type="protein sequence ID" value="KFB52351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ57"/>
    <dbReference type="STRING" id="74873.A0A084WQ57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020567-RA">
        <property type="protein sequence ID" value="ASIC020567-PA"/>
        <property type="gene ID" value="ASIC020567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020567"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003136"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013415"/>
    <dbReference type="OMA" id="GNKNVVR"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000217">
        <property type="entry name" value="Combgap, isoform F"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001137">
        <property type="entry name" value="Combgap, isoform L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001384">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB52351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020567-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="706" mass="77379" checksum="91F911A08F9384DE" modified="2014-10-29" version="1">MCAAQTNPPASFNYTTWGFAENPRSDSVVEISPNINYTVADGSSAMPYLHLPDGASIIVQKDAKGTIPHTNKTVRRMIVLPHDGSTVQQGTQRIITTSGTTATVSTGHTKKQNEVISKLVKSLFFLLANPYTVDQSNSTLANGIIDSKTKTILTAAGSGGAFMSPLGPIQLTAEECNDILMKRAAAAVAANNQHAITNSTDGHHTSIAVQVQKVIQGLEEGDDSQAATSNHQLKIEPTLSISPKLEAVEIDYNDYVQAEAATPTPNVVPKERPYSCDQCGKSFLLKHHLTTHARVHTGERPHVCVHCGKDFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRSFPLKRHLVTHSKFHAGERPYVCEDCGESFAQKEHLVMHSRFHGSLNPFVCQDCGATFPRKFQLVNHGKLHGRIPHSCTLCGKEFLQKRTLAAHMRIHTGDQPFPCIACGEGFRTKSELSAHNRLTHGGTNANSSSNATIITTNTVVTSNAQQQQQQQQQQQQQQQQQQQQQQQQQAQGQQQHIEVQQIQHHQGQQQVQEVANGNIITTIAATGQGSPETSPRPQYACRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAAIPGHLFPAVNQEYSLVGNPANGGATTLMTTSPVIQSNPPFPVQIITSSGQVQVLEGNTTQVIKYEIIHDTSRQSNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQC3</accession>
    <name>A0A084WQC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010954-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00020647</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525389">
        <property type="protein sequence ID" value="KFB52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQC3"/>
    <dbReference type="STRING" id="74873.A0A084WQC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020647-RA">
        <property type="protein sequence ID" value="ASIC020647-PA"/>
        <property type="gene ID" value="ASIC020647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020647"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001743"/>
    <dbReference type="OMA" id="PIYFIEA"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="480" mass="50228" checksum="69F870062D66575C" modified="2014-10-29" version="1">MLHVCYGVLSSGGMYKVCALWGVSNQHPSLENKPKHSLPKRPPCTLGGFISLGRAGDPGIIFSFSSSFSSGGVVAYVRTSFGKNQTNSSRSNTQLIGGGGGVGSGNSNNNLVGATGASSNGGGNSPLLLSQGFSVTMGATNNGFTGSNATMLNPSTQQTLNQHNQQQQLQQQTFGGYQLQKQPVGSASHKQQQQQSHGLGTHNALHRSVSQPATKATYANIMELLKLSGMQSVLNGDMVSAVATASAANGNSSNSSSSSSSSSASSVNSNSGNNGHHHHHHANNTSSSSGHRKLERTQSEPLPQQVNTSRYKTELCRPYEEAGECKYGDKCQFAHGMQELRNLQRHPKYKTELCRTFHSVGFCPPALSMSTGSDRASPIGSLSLSRTTSMTSFFPEASSPTFQQAAVQHAFNFPSSPPASPIDGLSPMATPPPSSPSLTAMKLGGSMVLGGGATVSGLEDRLPVFNRLSSAMDAFTNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQF5</accession>
    <name>A0A084WQF5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003578-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00020694</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025588">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525395">
        <property type="protein sequence ID" value="KFB52449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQF5"/>
    <dbReference type="STRING" id="74873.A0A084WQF5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020694-RA">
        <property type="protein sequence ID" value="ASIC020694-PA"/>
        <property type="gene ID" value="ASIC020694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020694"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003933"/>
    <dbReference type="OMA" id="WNFPLDM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB52449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="489" mass="52667" checksum="C8B30216BCC474D5" modified="2014-10-29" version="1">MANPNQEIKYTKLFINNQFVDAKSGKKFATLNPATEKPIVEVAEGDKEDVEAAVRAAKAAFARNAPWRQMDASGRGRLLNRLADLMLRDIDTLANLESLDNGKTFGDSVFDINCAIDTFRYYAGWADKIHGATVPSDGPVLTYIRKEPVGVVGQIIPWNYPILMLTWKWAPALAAGCTLVLKPAEQTPLSALYMAALSKEAGFPDGVINVVNGFGPTVGAAIVAHPEIRKVAFTGSVETGRIILNGASTSNLKKVSLELGGKSPLVIFNDADLDEAVEIAHNAIFANHGQNCCAGSRTFVQEGIYDAFVAKAAEMARNRKVGDAFQDGIQQGPQVDDEQFRKVLGYIESGKQEGAKLQAGGKRSGTVGYFVEPTVFSDVTDGMKIAREEIFGPVQSILKFATLDEVIERANSTEYGLAAGVVTKDINTAITFTNAVEAGSVWVNCYDYVVPTTPFGGYKQSGSGRELGYSGIELYLETKSVTIKLPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQM0</accession>
    <name>A0A084WQM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP009214-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00020761</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQM0"/>
    <dbReference type="STRING" id="74873.A0A084WQM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020761-RA">
        <property type="protein sequence ID" value="ASIC020761-PA"/>
        <property type="gene ID" value="ASIC020761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020761"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004435"/>
    <dbReference type="OMA" id="FIDWILD"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
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    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB52514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020761-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="30485" checksum="2679C957AA1E2886" modified="2014-10-29" version="1">MTSQTPPARQLRRRIDLLDLQGCGVYSEDRVAITVLFQFPWMALLRSNGAWICGGTLINVRYVLTAAQCIKDTTIDTVRLGEFDLNQAIDCFPRAECAPIPQDIAIERTIIHEQYSVRRKANDIALLRLVHAATENENVIPICLPVTPEMQPAVATYYVAGWGTREYKKHSNVLHHTKLILVSKDECQMQIRKEERLVPIFDTQVCARSVNNHSDYCSADAGGPLKSLGKNGRLVQYGVVSFGLSSCGKQSSVGVYTRVESFIDWILDKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQN1</accession>
    <name>A0A084WQN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020773</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQN1"/>
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        <property type="gene ID" value="ASIC020773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020773"/>
    <dbReference type="OMA" id="NANQTIM"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020773-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8740" checksum="5DA10E17AA4C4C20" modified="2014-10-29" version="1">MQEREIDREENANQSIMYQKNIQQRDTTDSEVGRWAELVRRRALRIADLRREFQGWHGNHERHCILHDVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQX5</accession>
    <name>A0A084WQX5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020869</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB52619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020869-RA">
        <property type="protein sequence ID" value="ASIC020869-PA"/>
        <property type="gene ID" value="ASIC020869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020869"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013081"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12303" checksum="659251850AC4FD91" modified="2014-10-29" version="1">MTAAITVRDGSRSEICACVKRPAGSSRRELGGTVRSSRTHSLSTTVGGGTVVVVEEREMEGRKNTIGKHQGHHWPWSRSYARDSSVIVGLVLLLLLQTIEVISLNNYTTVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRC8</accession>
    <name>A0A084WRC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP002469-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00021037</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026020">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRC8"/>
    <dbReference type="STRING" id="74873.A0A084WRC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021037-RA">
        <property type="protein sequence ID" value="ASIC021037-PA"/>
        <property type="gene ID" value="ASIC021037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022735"/>
    <dbReference type="OMA" id="WISFQCR"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051744">
        <property type="entry name" value="AP2_assoc_SerThr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907:SF4">
        <property type="entry name" value="BMP-2-INDUCIBLE PROTEIN KINASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47907">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Hcy-binding" evidence="9">
        <location>
            <begin position="758"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="997"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1071"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB52772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1097" mass="118167" checksum="4197D6E4928FC599" modified="2014-10-29" version="1">MKKFISKFETKNELTTTSSSRETNSFVGKTFKLSKENVVTVEEVLAEGGFAVVFLVKGAKGERYALKRLYVNNEYDLGVCNREIKIASNLSGHKNIIGYIDHSIVAKGNGVHEILLLMPYCKTNLLTLMNARLGTGFTETEVMQIFCDVAEAVARLHQCQTPIIHRDLKVENILQNDLGHFVLCDFGSATARVLNPNTHGRTVVEEEIQKYTTLSYRAPEMIDLFNGQDITVKADIWALGCLLYKVCFFTLPFGESALAIQSCQFSIPDGSKYSRGVHQLIRYMLEADPEKRPNIYQVCELAFGIVGRSNPVRNLTKCTVPSLESLPVPPFESETKRVPTIGAGVGQPGATPKATKPAGQLPLEGGTSVAPRQRPKASQAATPNPVGVVNSFALGLPPNPSPKNILSSPTPGVVPAPTVSHAVPSAGSDAPEVFVAKFAANFPPPAVGRGAELSTPDAGPTVVQQASQQPVAVAALFQTTYPDPFREADFGSTGEKNASSSSLTMVQSPSHAPSSHATIPATTGGSNSSSNSGGVPGGPILAPPKLAAATGHRRNVSDTSAFNKAFATETSQFLAPYEQSTYNNDNQPVASDGTPPVTLGSNGSLHKQHQQQQQQQYSSISGVAASVFETRSASLAASSNPQLNHQQPAQHRSASSGGSNWNPFGDPTPFAQMTEDLIFGEEFDKIRQQGSQGSLQTPPLEVVPRHSSLPLIQGTMLPGGRSLSSATVQAPAAQFSPENIPDELEDPFSSAPFSLPVKGKSFKLSSRKVIVIDGGFSTQLAEHVGSKIDKDPLWVSRYNATNPAAVLEAHLDYLKAGADCILTNTYQASIEGYMDYLDLNEDESIKLIKASVDLARRARTRYLAEKLENKSHKIPWVVGSIGPYGAHLHDGSEYTGSYADQVPANRLQKWHRPRINAIVEAGVDALAIETIPCRMEAEALLELLTAEHPTVRFWISFQCRDGASTAHGENFAETAIALWNRAKELANPNLLAIGVNCVHPQFALPLLQSVNERRGAATPTDAERIPLIVYPNSGEQWDAGAGCWRGAENLTPLETYIPQWVELGAKFIGGCCRTNARDIKRMKKTVIGLYGSRGSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSE4</accession>
    <name>A0A084WSE4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP008308-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021493</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSE4"/>
    <dbReference type="STRING" id="74873.A0A084WSE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021493-RA">
        <property type="protein sequence ID" value="ASIC021493-PA"/>
        <property type="gene ID" value="ASIC021493"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021493"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004625"/>
    <dbReference type="OMA" id="YHIETID"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021493-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="127" mass="14417" checksum="D3D8E4B090A79538" modified="2014-10-29" version="1">MARIADDSDFEALKRLVDNHDGWTLELSKSDTQVYTRPVAGCNFNMVKIHTEFADVTADVVFDVLHDPDYRKVWDSHMLASEEIGILNVNNDVGYYASKCAFNRLINGQDRPETRTLTSCCRRVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT28</accession>
    <name>A0A084WT28_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00021684</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01026812">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WT28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021684-RA">
        <property type="protein sequence ID" value="ASIC021684-PA"/>
        <property type="gene ID" value="ASIC021684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021684"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001275"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005993"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="368"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="520"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1153"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1275"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1300" mass="145767" checksum="85FD02F852EC21E2" modified="2014-10-29" version="1">MWNSERSQTNGGGGSGSSTRTLGMTSAISTAEPKPEDIQKTKELEKCLEPYNVFEAESELNHRMEILAKLNTLVKQWVRDVSIAKNMPEAMAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERADYFGSFFELLKQQPEVTECRAVEEAFVPVIKMNFDGIEIDLLFARLALKEIPDNFDLRDDMLLKNLDQKSVRSLNGCRVTDEILRLVPNIENFRLALRTIKLWAKRHGIYSNSLGYFGGVSWAMLVARTCQLYPNAVAATLVHKFFLVFSRWKWPQPVLLKQPDNVSLGFQVWDPRVNVQDRFHLMPIITPAYPQQNSTFNVSSSTRKVMLMEFNRGMQITDDIMMGKQMWDKLFEAPSFFYRYRHFIVLLVSSSNADDHLEWCGLVESKIRYLILNLERNQHINLAHVNPKCYEQHEQNSATTLNGADGKPTPFCSLWFIGLEFERSENLNVDLTDSIQSFTDSVHKHAVHIKLLKDGMKIEARHVRRKQLAQYLDPNLLKRERKISDSYTVSAGGPGGSNNGSASPADASSRKRKSTDPSSATPATASSPTAGGAAVPGSNGSASKKRRNDSFDGASNSSFCSNSSAVAPNPEDRKSPPQPTTTTTTTENSAGNGSGNQTDAPSTVDPPDASCLLNGGDDERLNGSDEPMASAVASEEQTDGKANDQDSGAWMLEIQTETPSTDVERRVESVLTDVCRKFSITSVRWLTVYSRNVLTTSESEREREHNELFEFRKIMSNRTACSQLVPRDYPVMITKEELQSDCKILEGKFITPLEIYMPGLVPEVAQQAHFQIVLPLKWNDERFKPICIHLAGTGDHYFWKRRNLIVKPLLKEANLGAIILENPFYGLRKPKEQRASSLQNVSDIFVMGGCLVLESLVLLNWCERNGYGPLGITGLSMGGHMASLAATNWPKPLVLVPCLSWSTASSVFTEGVMSHSISWDVLETQYFADGNFRERLSKMVTVVDDAFVAGKHFIQNFNKSVEELRQDINETKDLVCGEPTSDVNLTVIREVTPERDQQQEQKDQQDQQQDQQQQLQQSSSRIHINRTNVLNLSEPLLNKLLTNVKCELTQEEIDELNMKIHLALKRHNEEIEAEGEGDTRTNDKLILEVKTEGIPSTEGSTTPASTKSVGSKIMEYISWGSSTSSSSPSLPDGEKRPPIDTTKQRWWEREALQFMRGMMDECTHLKNFSVPYDTSLIIAVCAKDDAYIPRDGCTSLEDIWPGAEIRYLDAGHVSAYVLHQKLFRSCIIEAFERAKKKWIPEQEPLRGELNGHPSGPAIDNGPQEPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTA2</accession>
    <name>A0A084WTA2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021951</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTA2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021951-RA">
        <property type="protein sequence ID" value="ASIC021951-PA"/>
        <property type="gene ID" value="ASIC021951"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021951"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000228"/>
    <dbReference type="OMA" id="HKYLGRW"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19437">
        <property type="entry name" value="lipocalin_apoD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000003">
        <property type="entry name" value="Apolipoprotein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF62">
        <property type="entry name" value="LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013432751" description="Apolipoprotein D" evidence="10">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="11">
        <location>
            <begin position="38"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021951-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="21243" checksum="CB66B5368C94786B" modified="2014-10-29" version="1">MKSVQLIAAAFVLGLVQLVSAQQVGIGACPNPPVHINFDVSRYLGLWYEIRRYEQVFQLGGECVTAEYSLNADGSVRVFNSMVVPPAQARSSDTGRAVIAFPDESPLEAKLNVTFGTNPDIDISANYWVLGTDYDSYAVVWGCFGVGDTLRAESAWILSRTPQLSPAASQQVQGFIDLYLDEESLRTTMQDPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTT7</accession>
    <name>A0A084WTT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004556-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTT7"/>
    <dbReference type="STRING" id="74873.A0A084WTT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021873-RA">
        <property type="protein sequence ID" value="ASIC021873-PA"/>
        <property type="gene ID" value="ASIC021873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021873"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014501"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="36"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021873-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="503" mass="57344" checksum="2AF14467F6C95B63" modified="2014-10-29" version="1">MKKKSRKPLSKAQKQRNRVKVAAPIEEEPTAIKNAPHTFVIRRGERCSSVSKLSRDFRRMMEPFTAAHLRERRINKVKDFVHLSSYFHVSHMCILSLSTETLSLKVIRMPKGPTLTFRVHQYTLAKDVINNARKQFVDEDSFKTAPLVILNNFSGEGKHLKLMATTFQNMFPSINLSTVKLSSLKRCVLLSYNPVSKLVDLRHYTITAVPINLNRGVKKIVTRNIPDLGRFEDIADFVEKGHLLSESEVDDEESHVVLPQTLNRGNLEDNKSSLRLHEIGPRITMRLMKIEDDLLTGEVLYHDSIEKSAIEVEAMRKKRAQQRKLKEMRKQKQADNIKKKENKKEDHRAKTSAQEKSNQINETDKLLLKDAEEAVGDVSDEDDREYYRDAIGANPDDELFDSAHKGARKRPFIPKGSNYSLKPKKPRTDNRKQYDDDDDDRHESKNRKGSGGKNGKGKFGRKGMRDELKGKSIYNGGKHTGRGKSGGPKKTGGGKKFSSSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUN9</accession>
    <name>A0A084WUN9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prisilkin-39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022178-RA">
        <property type="protein sequence ID" value="ASIC022178-PA"/>
        <property type="gene ID" value="ASIC022178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022178"/>
    <dbReference type="OMA" id="SGFRGYN"/>
    <dbReference type="OrthoDB" id="7744250at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785174" description="Prisilkin-39" evidence="2">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22271" checksum="A4124C8AD4DE59F1" modified="2014-10-29" version="1">MISTGILFKMLLLTSILAQVAHALPQRVRREASKPLFADPLVADGKGEGAADATSSSSELLPSTQGSARTQRSYYGGGSSERLFDLGLLGKPYYSGNRGYYPSGGYYPQGGYYPQGGYYPQGGYYPQSGYPSSGYYPGTNTLGVGSYGGGSGVYGGYGGYGGFGGNGGLQSYYGYNNDNYYGNRNLGYGYYSGGSPSTYVGSTLVSGFRGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA65</accession>
    <name>A0A084VA65_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP002804-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ML domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00000407</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01001920">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524012">
        <property type="protein sequence ID" value="KFB34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA65"/>
    <dbReference type="STRING" id="74873.A0A084VA65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000407-RA">
        <property type="protein sequence ID" value="ASIC000407-PA"/>
        <property type="gene ID" value="ASIC000407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000407"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005292"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783162" evidence="4">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="15764" checksum="2752D4843DE838A0" modified="2014-10-29" version="1">MFRVLLLVALVPALASATEFFACGGGRPLPTSVNIEGCPSGTCNLVRGSDVIAFIDFTAGKSRCSVDDHGCNRDGAGRHDDYPLGSNSATCNFLQGSSCPLSAGEDVTYRLTMPILSIYPLVSLTIEIDVVDAAQQSVACFSVNAQVVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAQ6</accession>
    <name>A0A084VAQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002511-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00000871</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAQ6"/>
    <dbReference type="STRING" id="74873.A0A084VAQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000871-RA">
        <property type="protein sequence ID" value="ASIC000871-PA"/>
        <property type="gene ID" value="ASIC000871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000871"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003311"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003672"/>
    <dbReference type="OMA" id="MLPASCK"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="974"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000871-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139953" checksum="68F2EA21C0CC230C" modified="2014-10-29" version="1">MPGSSPGVPEQQTPSAEETEQPKHAPRRSTTFEVVVVVGACHVRKIPLHKYSARPAAQWYVTGVPGAVKKERTPGRGPSLSVWHCSTPLSVGGLRKGKLVLPSSYTAHGDDLDIQLHADPLELQATVGRLKLQISRTLPAGAGTVATTLDIRLDANHNVTQIKVPCYHFLHGGDYELAVLEEGVGHQENPARVIDERLRQSLKVEWPAARLAIVPNRTDTYPEAKVQGILEFADVRCQLPAKGADSLDLPELWLELIYCGKSVESCSKANATVPFSKAQILYIEQVRGLPRSRVIDFRCDLFGLAGFYALHLKPSAASQTSDPSMGSLLQARALLQADWSKQYVFTVHTRSIFPCDPHGPGIRVLFQYPACILNQADRVRVYAKLRADVLSLAPPTSLHYIAEQRVSKGQHSLYFECDLFYEKFVEYCFVYVSQAISGAVADIRMDCVPTLPVSASDSGGWGPWSNWTHCSTTCRGGIRNRYRFCDSPPPRYGAKFCEVASVQTERCGSESSGDSWECMFSPAIGNINLPLEIEDVNTEIGPGCRCGCVIHLGMVKPKRLLGSSSHSCPDRSLWLIKGDEGCHIRMTIDFHKFPCDGQWLKIRDGDSVADELLLQFGADQTGSEGSGTVAEASSNVLLVEFFSRKSEHYEEACNAGFLGQAEQIKLNQSVIMVPGNNTTIASKVIMPIVQSLRSYASFTIAHVCAIAFICFIVLVSFLLVVQYLFRYRKYELATSRMEAADSPAHTLFGSSQSLGGVAPMQPRSRAVSTTTLISEIVSYVKLRPLRATTSIKHERFRESVEYTLESTGSRSEGGPSDGSTEIIMELQDRGTEGDQSRRDEVDEETPLQSLNDLNHPEGRTESPRRLRKVSDSSRGPEDAHESDDERSTTMSSAYSSLNREKTPLVTRKSGTANRSHDTDTLRSDQHLVKSATCLMTTSSTSTATLTNVSPSDVVSWWFGECCSPPDPGVQSPLTRRNTGTSSTRGTRNAKESKEKRNLQKLLAGSDFSLGAPSEQDMEMDYYDYNVINAGAAPGSYLGMDPAFLVWIPPLDDDDENENEDHPAKNAQGEDLSDDEDGELRELTNREREGEPRSASVTPSAELIRQLAEQKRNDYIIVSHSISKSDVCSESDGDTKLSTERRRRKLHELILVRRKGDSGGDSGSGSSVRKSSSDESAEEREKETSFTKSPVDNKQISDFYEMADIAFADDEADEEEEEDDGKASPGSGGGFGEEHPKGGTLLPSARIVEGSKEESKYQSVVVAGDLRREGDHLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAU2</accession>
    <name>A0A084VAU2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005329-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00000955</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01004461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524214">
        <property type="protein sequence ID" value="KFB35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAU2"/>
    <dbReference type="STRING" id="74873.A0A084VAU2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000955-RA">
        <property type="protein sequence ID" value="ASIC000955-PA"/>
        <property type="gene ID" value="ASIC000955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000955"/>
    <dbReference type="OMA" id="LEWELYC"/>
    <dbReference type="OrthoDB" id="9994280at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="746" mass="80262" checksum="AD9D481594A0F8C8" modified="2014-10-29" version="1">MHARGGSQWQSRRKTSLGPLRRAHPASGATWNVQVVRGKMTSRCLWHACRALVLGMVLMFVGGAMATVGYYANNFPSLSDVRSNSTSTIRVKNEHRGLHLNNLSYVGPIIMGVGGFIVVASCVMTFEARDSAAKVVPARFKITGQGSARNPNSRNNTSRRSTGISNGPASLVLGSQNARWEQHLGVFRTSPATEQVPDRKALTAALVHFSKALGTPKTSPHRRPSESQSRRVSRSGSVPNLYAEKLSVPSVTSGSPANIRSETVGHRHHRGSRVSSMVQRSTRDTCGSSGGLLHPGMLQFHRHALSVDEPEPFARTLKQAGSHGSVQYGYGGEIVPVHKMRDRNKRSDTARRHVLSRQTKIEKDESLGSPKHGHISRRASTISNTSVSSKPHRSSRRASTISKTPSVDSRGAASTVDINSLDRSLLMGLTPPRKGVPSAAPGPISMPSGDKEYRSQLSICSEPVAISQRNLSCQSSLEPCVPEEESSPEQEHGQRDETGLVREEDRPSMPLEPLSVTNPPLRPDSLVLEPDSDERTAPNRFLYRSNSSKSFRKPKPKAASKKRSNEYDQIYVISSGNGGGGGGSGGSISGANGTTAPGSGRYPNFHHATMMARNNDDDHYDSIEVIHERRSKNFSKFSTSGGGGDGHDGRQDAVADSVDGEYRKMGSNTISVVADISPAPPIALAPELTADNDAPPGNEVLVGNGTPERTENACTQNIILNSQPPEGAERLEQSQYPATEDATPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB27</accession>
    <name>A0A084VB27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001145</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524266">
        <property type="protein sequence ID" value="KFB35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001145-RA">
        <property type="protein sequence ID" value="ASIC001145-PA"/>
        <property type="gene ID" value="ASIC001145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001145"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001145-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7347" checksum="41136CC3ABF3E226" modified="2014-10-29" version="1">MRTRVASAHTYTGAYQVSGVVVSRGDSLPTPGGRTIRNRNRSSVRQEPEAEQDTEHCYGATGGNDPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC28</accession>
    <name>A0A084VC28_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Fumarylacetoacetate (FAA) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002290</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002290-RA">
        <property type="protein sequence ID" value="ASIC002290-PA"/>
        <property type="gene ID" value="ASIC002290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002290"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759799" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002290-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11718" checksum="C50815624DE44DBB" modified="2014-10-29" version="1">MKNDVVVMLSLCTTVTCTDANRDVSYRNPSVECFSQQEAGPSSSIEIVNHSEKHSGGGCQGSPWERWNAMNFECSVLKCIPFSYAAELCAVRVAIRNRGWLRSPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD19</accession>
    <name>A0A084VD19_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010041-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00002802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011130">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524642">
        <property type="protein sequence ID" value="KFB35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD19"/>
    <dbReference type="STRING" id="74873.A0A084VD19"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002802-RA">
        <property type="protein sequence ID" value="ASIC002802-PA"/>
        <property type="gene ID" value="ASIC002802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002802"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001049"/>
    <dbReference type="OMA" id="CHENDHR"/>
    <dbReference type="OrthoDB" id="192402at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042508">
        <property type="entry name" value="FBXW5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002802-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="635" mass="72633" checksum="AFE7E234769716B0" modified="2014-10-29" version="1">MAEVDDVPMADASSTSSTPSEQDDDGLFLDNSPWVFLPEPLFNTIFLQLQPRDLLNASQCCRRWHKLSLDDYIWKKYFQAEFNVDPSIPLKRGAESWRAEYRRLTSNVPMVLTDVLTSHSHQVLHVSFSHNGKMFATCSKDGFVILWNSAYPSTIRDSYDMRKLSWKYTQFSQFNQSDTLLLVSGVHFGSPHSTSGEIAVFTVQSKFLIRRFDGSVGIMCFKKKENRFVTNPVLLPLYMHFINSDLSIGVYVGLIDFRICSSSGQQATDEDPSEDDRRAGNPLSHYQMNQDVDSDEEPAAEAADENLRNPPANPAGARQQPPDHGEYAGPIQYVEEFRQEYEDSYYESSDDCLGDDDDDCDDEELSEGDDDLENLCPKYLIFSTGSKTYTPHQIGFKRITSVNFPRRLDPGPSLQERIALRDRQRELQNESPPMEPNWNNYDEVAGRFDKVDKLIDLHGHIIGMGLSPDHRYLYVNSRPWPKNCVIRNPLQPPAIAQEIDIHVIDLMTLKKVGKMLRAHKAYTPNTECFFIFLDVCDNYVASGAEDMHAFIWDRYYGVCLAKYQHDNVVNSVAFNPRDNEMLVTTSDDYEIKIWRSLSKAKKLGIQPVGRASEYRKNKVNRPPPQPHQYAGRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDC4</accession>
    <name>A0A084VDC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal_L2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00002948</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC002948"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002948"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020608"/>
    <dbReference type="OMA" id="EHNKEHV"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03947">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
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        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002948-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="297" mass="32971" checksum="BD3B564956E3734F" modified="2014-10-29" version="1">MANLAKLFQRLSITTLSRDVRHTCVRPISLESLEIYLNKPKPGGGKSFRRIVHYPTEYTVEPLRVTNLAGRDPETGRLIAKGIGGGIKHKYHWIKWVRDGPLEGPPQVEKVIDVIDDGCRTAKVALVAVGNEMKYILATENMKAGDLIKTSRFIPRIPVRANEGDAYPLGALQVGTLIHCLEKYPGQPCHLIHAAGSYGTILRKFGDLVVVQLPSKQEFAFQQTCMATVGRVSNIAHSKTPIGSAQKNRELGNRPRSGLWHRKDGRHGRKVRRLPPMRVIPPPAEKAAEPLKLTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003055</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ASIC003055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003055"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="8964" checksum="62F321F2DBF54D72" modified="2014-10-29" version="1">MRGCGAVDASLPASCLEHRLHFTSTPPGRSGRATSGLRQPADDKSATVPSPLGRPTPPTLGAGGIRNKAKNELTTISSTEPEGSVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDM1</accession>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003095</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC003095-PA"/>
        <property type="gene ID" value="ASIC003095"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003095"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003095-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7405" checksum="D133BF0790EDE46F" modified="2014-10-29" version="1">MPSAMLKHFDENVQTDPFRSGAHPKRNHNSPCVKAQVNDPLATWRHTRNLWFLCSATAFGARENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDR5</accession>
    <name>A0A084VDR5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Lim homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00003153</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011699">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011700">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011701">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524712">
        <property type="protein sequence ID" value="KFB36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDR5"/>
    <dbReference type="STRING" id="74873.A0A084VDR5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003153-RA">
        <property type="protein sequence ID" value="ASIC003153-PA"/>
        <property type="gene ID" value="ASIC003153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003153"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013917"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013998"/>
    <dbReference type="OMA" id="RCCKCLH"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000136">
        <property type="entry name" value="LIM domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="353"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="479" mass="53603" checksum="6B9D54BCF4C5D772" modified="2014-10-29" version="1">MERRGSITVRWVIRRDTTFVLAKSLPHPFPHVPFLLHHHHISFVLDRSIERGTEAGEACLSRQLDGRIVNAFAYLLWMPPPSNAQVPAFPPLTLSFPYLNIYGRPYYLLVADRAWHNQCLRCCKCLHNLEAELSCYSREGNIYCKDDYYRHFSTRRCARCGNGISASDLVMRAKDLIFHVNCFSCLICGQLLRGGDTAGIRDGRVFCGEHYESEVLSEPETISPQFFPVTTAGGMSVQPSQKGRPRKRKLATPQPPTLLLDATGPQHLGPQHPSCPSQQQQQQHQQTPTQPQPPQLQTQQTNPPQPLEALDAGTPLRLDLLHKELNVNSLDLSTYDGSQSPGSGGALTPNCRTKRMRTSFKHHQLRTMKSYFAINQNPDAKDLKQLAQKTGLSKRVLQVWFQNARAKWRRNVMRQDVGMGNPGHGMGGLPSIGTGGMHHQHHHSASGPNGTGDGSVNVNDLSSTQVLEEMHNMTFAELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEP4</accession>
    <name>A0A084VEP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003475</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC003475-PA"/>
        <property type="gene ID" value="ASIC003475"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003475"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003475-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="13966" checksum="ECBEEE88B20365A0" modified="2014-10-29" version="1">MGIVCKDDYDQKPRGHPGVGPWEAAVAVAIAEEKATTQNGAAKGSQKLVGPHFNGTDFPRHGSDIFLSENVRKNISFRAGRGGDVGDVHKGSIFQRLGESLSIVSAGARGEGMRIMGSSKIRLYIIGCARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFH0</accession>
    <name>A0A084VFH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP008580-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003864</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003864-RA">
        <property type="protein sequence ID" value="ASIC003864-PA"/>
        <property type="gene ID" value="ASIC003864"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003864"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021643"/>
    <dbReference type="OrthoDB" id="7727300at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003864-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="214" mass="24771" checksum="14B9150C2AD854A0" modified="2014-10-29" version="1">MEVVQRLKDIEPKHAEIKRRFINFLYSAKLNVVERMDEFYLQLFTEKEGSLTGSIVLEDAMLYQLDHQLESADRSCIDTLRNIVDSNMNVAGIGYTNCINSVQEGLESELEKVQKLLQFDESKILYQRLLDVFEGENIIYDPERILAKLKDKGFEIDAMGSDCLLGVFEIVEKFAAALDDLRIAYQMCLIENEYILRTAYESTISQLTNICHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIE3</accession>
    <name>A0A084VIE3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005050</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIE3"/>
    <dbReference type="STRING" id="74873.A0A084VIE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005050-RA">
        <property type="protein sequence ID" value="ASIC005050-PA"/>
        <property type="gene ID" value="ASIC005050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005050"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022122"/>
    <dbReference type="OMA" id="IWEVEFF"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.770:FF:000002">
        <property type="entry name" value="recQ-mediated genome instability protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1020">
        <property type="entry name" value="RecQ-mediated genome instability protein 1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032199">
        <property type="entry name" value="RMI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044881">
        <property type="entry name" value="RMI1_N_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16099">
        <property type="entry name" value="RMI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="8">
        <location>
            <begin position="79"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ-mediated genome instability protein 1 C-terminal OB-fold" evidence="9">
        <location>
            <begin position="498"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="638" mass="72271" checksum="693E901879F04390" modified="2014-10-29" version="1">MIQNETNRAQQTKQRFIREYNIKVLDEWLSGCVSFCLQENSKISNESLFQFAFSQWLLADLNEVGVGAFAPGLGEKIDSHMLTGTFPVQMQYLLDISEPAYEQWRNLYDKKLDEAEDEVQMRKSQAPQTKKRRMLKLELTDGKQTAIAMEHTPIRCLNTKLAPGVKLLLSGPIRCVNRVLFLESKNVRVLGGEVDILLISNAYENVLLRALNKPANPNPKIDYEEPEVVENKHRPNHSNIQPVPMENYRVVGHDERKPVVRKSPPLVVDDVDDDSLLMGIDLDAVEASQPRVAPVSKPEQVASISTLMDDDELDDIVQLVEVPDDPEVMDQQVSSTKHSQPSPKPRIAGFVRPTFDEPLDDDFDLMNSLENQIQSEFRGFQSEPPPEHLVPPVAKKSRVLDEQFVTPMQVARKPAAPPQPPSSSFQSNSNKHPVSPQPSSSKMFNRFSASSLFEDSMDCVETEELPSPSANITSPNYTFRIDGTNLATIDQIVALPEDKLAGASFVVYCEVSAVTEQPRIRKERWHLTIVLTDQSEQHLPVRLHNDVIAKLVRHDAGELMRMHKTDREGVMKLLDTILAEFKELLQEIKCFWRVVYPTMAGNSELPVVMESYEMNDERGSILLDKIIKENCNQLRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIN6</accession>
    <name>A0A084VIN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP011737-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00004999</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013373">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIN6"/>
    <dbReference type="STRING" id="74873.A0A084VIN6"/>
    <dbReference type="MEROPS" id="M12.A51"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004999-RA">
        <property type="protein sequence ID" value="ASIC004999-PA"/>
        <property type="gene ID" value="ASIC004999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004999"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011895"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023279"/>
    <dbReference type="OMA" id="YPWESTT"/>
    <dbReference type="OrthoDB" id="9936463at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04272">
        <property type="entry name" value="ZnMc_salivary_gland_MPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034030">
        <property type="entry name" value="ZnMc_salivary_gland_MPs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783430" evidence="10">
        <location>
            <begin position="22"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="371"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="705" mass="78492" checksum="5C19AD6CBCD25064" modified="2014-10-29" version="1">MPFRFVFVLRIACCVQTCVQGEAKPRNPLFQRSKPWSGCASARLCDSERQGRSSAESARGETIIHRHMSSAQLQEVFHVDHVDLVPHYELVKLTHHTNTPVLASVRRKRSIESASSSATAAGSKSNGLNDAGGNSYSHHVKKDLSKVRFTEKVSELPVKPGQQRKPVPTTRQQVPLEAGPVLNSEQDDVITIEPLVESAGISIADMAEHRVSFDAFGENVNLTLRKTEGLLRGGAHSLRMWNVRSDPNSTQGLVYEEIHDEVQPADSFGDIYQDEDNMAAVLMRKHLESGDLMMEGSIGHELVIKPVPTEVSQEEDGSVHHVIYKRKTPEEHNDQLSDYAFMEPDRLQKRFRAKRSPQGYYKSSRAIDRTIYPEILVIVDYDGYRLHGGDNVQVKRYFVSFWNGVDLRYRLLKGPKIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRQYANDACNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAEKCRWEDGYIMSDLRHTERGFRWSPCSVQSFHHFLNGDTASCLHNPPHEDEALGRALPGTLLSLDAQCRRDRGTSACFKDERVCAQLFCFDSASGYCVAYRPAAEGSSCGDGQHCLDGRCVAEHENIIPDYSQHTPSYTRYNQQSVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJC4</accession>
    <name>A0A084VJC4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005348</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJC4"/>
    <dbReference type="STRING" id="74873.A0A084VJC4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005348-RA">
        <property type="protein sequence ID" value="ASIC005348-PA"/>
        <property type="gene ID" value="ASIC005348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005348"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018586"/>
    <dbReference type="OMA" id="MPVCELE"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="2">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="217" mass="24292" checksum="76935967213BAD6D" modified="2014-10-29" version="1">MAPPIPQPTKPVEHTAPRVFHYDFWKNPSESVDLDVLMPNGVIITMNQSIYLTLTELKGYVWEVAESKPLYRLLGDKNMYCFSTLASGTTNNGTYEVDDESRRLLDVQPVFGIFRFVEKKNVSVNSTLINNINALLGSGLSEKTLKNPEVNDFRTKMSQLGEEIGIERAAMSRMERIAYQYPVKLASSTNIPEQIKKDWPTVEGVVATAAATEVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLL0</accession>
    <name>A0A084VLL0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000603-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006343</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006343-RA">
        <property type="protein sequence ID" value="ASIC006343-PA"/>
        <property type="gene ID" value="ASIC006343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006343"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021367"/>
    <dbReference type="OMA" id="REYRNCA"/>
    <dbReference type="OrthoDB" id="7758746at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="18038" checksum="F7CCB4E6AD8D8C25" modified="2014-10-29" version="1">MSSRRILVQEPEGVMKSTLAILLVTVGAFVVAQQNAPYQKPVSSKPSGGTQPTLEQRTVAQQNQALNVSFAQAFTEDTPEEFQLMVMELYVRCQAELDNCADLLWETHLLREYRKCALTQRRFCTQEIQELQSMLEALVAAGSEQVVLTPEEEEVLRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLT9</accession>
    <name>A0A084VLT9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001040-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLT9"/>
    <dbReference type="STRING" id="74873.A0A084VLT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006255-RA">
        <property type="protein sequence ID" value="ASIC006255-PA"/>
        <property type="gene ID" value="ASIC006255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006255"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010858"/>
    <dbReference type="OMA" id="NHRNSED"/>
    <dbReference type="OrthoDB" id="8019798at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="20386" checksum="C8D24BEC75499BDE" modified="2014-10-29" version="1">MSSETTENRVEVEASAVDYKTQKREQMERRNKRNEDLARFILSRTSIYLIRINKALSQMAARYRLQEIAQAIFASLQEYPLLALGVAIVIFTFTLPFLVFIFFTMTTAVMAFTGFVLIEGALITAASVMLVSLLIGVFLMVAIIGMIFLTGYYSMSRMYEYTNKFNLENVREYLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLZ4</accession>
    <name>A0A084VLZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006638</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLZ4"/>
    <dbReference type="STRING" id="74873.A0A084VLZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006638-RA">
        <property type="protein sequence ID" value="ASIC006638-PA"/>
        <property type="gene ID" value="ASIC006638"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006638"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013203"/>
    <dbReference type="OMA" id="APECEGQ"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF38">
        <property type="entry name" value="HL01515P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="113"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006638-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="40819" checksum="F31AEAF389EE0AEC" modified="2014-10-29" version="1">MSIKYNEKNFPYIDLGKGYIIYLEDEDYTDERWVLKAEQELNETPENQARALEQLRELLRGEKKLTVPLEDEKFLLKFLRPLAYDVQKAFDCIRHTFLMKKNYGKDYYEGRIKPSHIRHIYDSGMVTFLPMRDDDGCGICITQLGRKWNTSKISMYDVVALFRINIEASLMDPLVQLNGIRIIFDFDGISMSHVAQASPKHAMVSLQWIQKCCPLPLKSIHIVNNSMLFNVMFTIFKPFISKELRDKMYFHNRDWSSLTKTISPKCLPPAYGGTLDAPECEGQLLGDFMQLYDKHYEGECQTPARNRFSLLSQSPLTNVRVPFSFPTHHGGSAFWGHHIAALDAFGYDETNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMA0</accession>
    <name>A0A084VMA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Dwil\GK21266-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMA0"/>
    <dbReference type="STRING" id="74873.A0A084VMA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006420-RA">
        <property type="protein sequence ID" value="ASIC006420-PA"/>
        <property type="gene ID" value="ASIC006420"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006420"/>
    <dbReference type="OMA" id="QYFVAMC"/>
    <dbReference type="OrthoDB" id="7740032at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006420-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="265" mass="29965" checksum="2AD0179C97CF41A8" modified="2014-10-29" version="1">MRAALTAAGFEVEPTAGPNEVERLYKTMLAGQLPGNSNSGQNGEASKRSDAKEIGAIEKDHKEATSAEMVISELQKEVKELRERIASLEVAVVEKNYLDQIALLVKPFSGDTFVTFQKWLPDLENAFRLLALNDKQKVIAIARLLTGSAEVFLRTIRVSDYTELKANLLKEFSAEFSQEEAIKFLRKRRLQANETVHRYVLDIEEMAMSCSVPEEEVVDIIIEGLGDATVYNSMLYGLRTVNELKQMIHRYERMRFGSSRRTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN85</accession>
    <name>A0A084VN85_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006917</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN85"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006917-RA">
        <property type="protein sequence ID" value="ASIC006917-PA"/>
        <property type="gene ID" value="ASIC006917"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006917"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006917-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="14716" checksum="BB239068BBBA8EF9" modified="2014-10-29" version="1">MAINELVNALTSDDGKNASIISPNAIRTCPATVSVTSLSGDPGKEKPLPAGHEAVVVKTVSYVFLDFLLPFPTVELKGILERSRNDQTMLPFRCVEKAEVNRNRSSRLNGFDSYHGFQLRRDDIMINLKQIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPZ9</accession>
    <name>A0A084VPZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007502</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525002">
        <property type="protein sequence ID" value="KFB40043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007502-RA">
        <property type="protein sequence ID" value="ASIC007502-PA"/>
        <property type="gene ID" value="ASIC007502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007502"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007502-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6527" checksum="878F867A9AB87814" modified="2014-10-29" version="1">MCKQRQRIVITHRVRVLRKPITPENVAHSDDRTSNIPPFAQISLAWGGCGGCGAVHFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQD1</accession>
    <name>A0A084VQD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000376-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007547</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQD1"/>
    <dbReference type="STRING" id="74873.A0A084VQD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007547-RA">
        <property type="protein sequence ID" value="ASIC007547-PA"/>
        <property type="gene ID" value="ASIC007547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007547"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017857"/>
    <dbReference type="OMA" id="SPHADID"/>
    <dbReference type="OrthoDB" id="5914301at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016357">
        <property type="entry name" value="Transferrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF57">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002549">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00206">
        <property type="entry name" value="TRANSFERRIN_LIKE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783744" evidence="6">
        <location>
            <begin position="24"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="7">
        <location>
            <begin position="392"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>hydrogencarbonate</name>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002549-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007547-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="553" mass="60372" checksum="EA99B0AD7E1F6A39" modified="2014-10-29" version="1">MNVLRTGRCMLLALALVVVGAFGAPSAEKDGGTVRWCVPEQLQANCSRLTSAAGVGIECVSGLDRTECLRMVRNRQADYVMADPEDLYVAMNMENQDFVVFAEQRTTEEPTAPFRYEGIMLVRAADGFSSLADLRGKKSCHTGFGRNVGYKIPVARLQRAGLLKLPVADGALSTVERELSALSELFSASCLPGTYSPHADIDALLKHRYANLCERCDAPAQCGKQDKYAGYEGAIRCLVENGGDVAFTKTIFVRKYFGLPVTPGGTAQPARNPAARPEDYAYLCEDGTTRPIADGTAPCSWAQRPWPVLLTNGDYSGTRFQRLQAVTSQLDQYYTDSQSTAPEADRAAAVALGIKATNPLVNRTELAAPRDYLQKANYVEVIEREGPYGSAVRLCVTSEPERQKCELLRRVAYSRDIRPAFQCVLKTEEACIAAVRSGQEVDVVVLKKHSAQLKPIVTEVFADHPAKTNGAKNGEGRAYVYVRPDMDEAAQDSIVHAFVALSETFGAGKPNALVFRLFGPFRVEKQADPVSNLMFHDNAAKLTSLNKNSLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQG0</accession>
    <name>A0A084VQG0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">3-isopropylmalate dehydratase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007578</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015207">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQG0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007578-RA">
        <property type="protein sequence ID" value="ASIC007578-PA"/>
        <property type="gene ID" value="ASIC007578"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007578"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007578-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16373" checksum="85E95B067BAF6B7E" modified="2014-10-29" version="1">MVPSPWGCDEGRRTSGGGGVCESISLSRVRRDRRLADSVENAPGYAKKCDAPWLLLHGPRPTDSILSRRLSSPAPGMQNILPAHEAHHASCPAFSWLEKFRKWLTFTQQIGVCLAKTSAFPPCAIRRNVEELLGCSARSNDQHEMVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQX3</accession>
    <name>A0A084VQX3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP007238-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007750</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQX3"/>
    <dbReference type="STRING" id="74873.A0A084VQX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007750-RA">
        <property type="protein sequence ID" value="ASIC007750-PA"/>
        <property type="gene ID" value="ASIC007750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007750"/>
    <dbReference type="OMA" id="IIDWAGG"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="15465" checksum="0956863F59093AFE" modified="2014-10-29" version="1">MSGKKGIDLLRTIASVMTKTNGYDRCLQQLVMVSGGDGRCLAEFKVQEEHLNRAGGLHGGFTATIVDVVTTYALMTKENAVPGVSVDIHVSYLKGARQGDEVLIDANTVRAGRNLAFLECELRHKKDNSIIAKASHTKYIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRM8</accession>
    <name>A0A084VRM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008133</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015749">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525033">
        <property type="protein sequence ID" value="KFB40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRM8"/>
    <dbReference type="STRING" id="74873.A0A084VRM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008133-RA">
        <property type="protein sequence ID" value="ASIC008133-PA"/>
        <property type="gene ID" value="ASIC008133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008133"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011022"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759884" evidence="10">
        <location>
            <begin position="31"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="122"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="244"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008133-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="36533" checksum="84FD7A35D34FCE9A" modified="2014-10-29" version="1">MIPGVGGVPRARLFALLLLTLVEVIARALGDPAPYVGHTALQGGGSSKAAGIFSSTKQNDVTSVTTQLAKAGGSTGASSDLWIHPEDGEALPVGAPRIERSTAKRHSAGATDTGSKYNFHFAHAVYNVSIPENSVIKTYAVQPPNEDRMGIHVTPDLEVKYKIVSGDKDKFFKAEERAVGDFVFLAIRLRTNNIVLNREKGDSYRLEVKATGTRREGKSRISLEADTVIDVRVLDANDLSPLFYPTEYSVAITEDTPLHKSILHVVAEDADLGLNGEIYYSILDETEQFAVHPTTGVITLTRPLRFTDRALHELTVVANDRGIGSTRNQASKARVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSE5</accession>
    <name>A0A084VSE5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP002414-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00008417</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525044">
        <property type="protein sequence ID" value="KFB40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSE5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008417-RA">
        <property type="protein sequence ID" value="ASIC008417-PA"/>
        <property type="gene ID" value="ASIC008417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008417"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000098"/>
    <dbReference type="OMA" id="DHTEKCD"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000016">
        <property type="entry name" value="carboxypeptidase D isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783973" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="986"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="52"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122460" checksum="B4E3056AA969063B" modified="2014-10-29" version="1">MIANVKLLSLLAVAIALNGLSVYGKTVQTATTAGDGVVTAIQQDESFLQQPHYRGNDELLDVLAHLQKEYPDLAKVHTIGQSREGRPLAVLEIRPNVNRPRPLLMPMFKYVANMHGDETVGRELLLYLAQFLLANYERDPEVHALVNQTAIYLMPTMNPDGYQRSREGVCESPPDYTGRYNAANVDLNRDFPDRFDDERTRHQRMKRRQPETVAVMSWILNNPFVLSANLHGGAVVASYPYDNSIHHHECCEDSPTPDNRFFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFGGAYELTLEVSCVKFPPASELPEFWHQNREALLQYVEQAQHGLTGTVQSTIGHPIARATIQINQLEHVSYTTADGDYYRLLLPGLYNVTVEAEGYESQTQEVRIPPEATQAVRVDFQLMRDDPQHWSSAYDFRQLENILKTRYHSDEELKATMGEFENRDYKTVEFELRGNEVSMAYPSIKVTDHIGTPEETKLHILIVSSLFQTAAIGREMVINLARHVLAGYNIKEPLYIKLLENAVLHFVPVKNDFVEIIQQFRANESVCNPMLRTDELADKLLNAETDHQKDMFLRMLKEEEYDLALTFAAGGHDVFFPHTDDQVAIYSRFADKIRGHKYRQAQSDQCAVDAGQLHQVESTQHVTNAIHNLYEVPLFTLQLGCCKMPTETSIATVWRQNLDRMRNFFRLVDTGIRGYVRDVNGNPLRRAILRVQGNKLIYKVTPNLAHFRIVLPSGSMNIEISCFNYTSRMVPIKLNEDQILDLGDIVMQEAARPRESIVAPPVPAIPHAPPHQGKDFAVLEPSKTMKVFPLDGGVEIKTDPAGSAVSPVRLSGIVLDDANHPLPGAKVYVTEGKTKGGKILATGSTGQLGKFQFEDGIPVEKDIVVHAEPSGYEAGEKQIRLGPVGGASGLVFHLTRDERVLGLPRLLFVILAGCGSVGIIACGILCFTYIQARRRDSRYYYNFSLLPQKGDLNRKLFDDDEETELFRASTTKLQPYFDDERDPLTDTEDDSEEEIVMLNPSFRSVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VST6</accession>
    <name>A0A084VST6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008648</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VST6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008648-RA">
        <property type="protein sequence ID" value="ASIC008648-PA"/>
        <property type="gene ID" value="ASIC008648"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008648"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008648-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7297" checksum="219295A26D106BF3" modified="2014-10-29" version="1">MIGTEDLAIKRGAARLAIIVSHRRGHCCEDEGLPPAKRAPLLPCWGGSLPSPPGSVVQPVATKQSAARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTK8</accession>
    <name>A0A084VTK8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00008897</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01016361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTK8"/>
    <dbReference type="STRING" id="74873.A0A084VTK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008897-RA">
        <property type="protein sequence ID" value="ASIC008897-PA"/>
        <property type="gene ID" value="ASIC008897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008897"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014261"/>
    <dbReference type="OMA" id="GDPPEFY"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10809">
        <property type="entry name" value="GH38N_AMII_GMII_SfManIII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000042">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000009">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000007">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF70">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="12">
        <location>
            <begin position="534"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1168"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB41302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008897-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141929" checksum="B199D7C89D87C76E" modified="2014-10-29" version="1">MTVKLFRRGSARCIGLLSAFVTILLCLYYISMGQPSPAGSGPSVATGMGGLHGKDMALAAHQKRSNGVGGVAQHTGPNANHSWHSWLRNSLHSIGGAAGQRHHRVPGADGENGRAVDTDEFEDGPGGEGADGGGGPLPRFGSRWDECSALQEASTDISTVDEYGKFDFQPEWMKTKEYWDKDFESRYEKLQKDPKRPPLKIVVVPHSHNDPGWLKTFVNYFQSDSRQILNLAVTKMPEYSNMSFIWSEISFLQLWWDQAHPTKQRILKKLVQSGRLEITTGGWVMTDEANAHLYAMVDQLIEGHQWVKSNLNVTPKTGWSIDPFGHGSTVPYLLAASGFKGTIIQRIHYAWKQWFARHRYGDFLWSPYWKSSPASSRAHTMLTHNMPFDIYSIKHSCGPHPFICLNFDFRKIPGEYTEYSIKAQFITPENIEAKADLLMEQYSRTASLFPHNVALIPVGDDFRYNKEKEMEQQYTNYKKLIDYINEHRSRYNAEISFGTPVDYFNAIRERYDRFPTLKGDFFVYADIFNEGRPAYWSGYFTTRPYYKILSRELEHNLRSLEILFTIAFNRARQASNSNAFKIYEKNYEKMILARRNLGLFQHHDAITGTSKANVMRDYALRLFESIQDTVKLQEKTIELLVQRRSSEQQPHSFLIGELERDNFGKLPRKTPIIVTEGRSTDFIVYNALAQERLEVITIRTLTPRVKVLDAGGKAVDIQINPVWNITETSYTSRKIVPSDKEYEVMFVARLAPLSLTTFTAAYDDDGYQGKMATLYCNECQDEKNKVFEVRNKQPGDIQLENYKMRLLFDEQSGFLKSVTKKNMGKQIQCAIKFAAYKSAQFHSGAYLFKTDPEQRNSEKDVLEQYGDLTILITSGPLASDVTAIYGPFLAHTVRIYNSNSVLDSAIYIENDIDFEAPPKNRETELFMRFVTDIENGASENPEFYSDLNGFQYQKRVKVSAIGVEGNYFPITSGAFIQDDRMRLTLLTTHAQGAASLEPGQLEVMLDRRTLYDDYRGMGEGVIDSRLTRHRFWLALETIDPVTVKPEAGSPEAAAAGAEDKKVDEYQLPSIFANSLSNGLNYPANLFIVERYDESNQIELNRAVRLLRVQFPCDLHMLNLRTLTESNLPLFPSSSALLVLQRQGYNCRIGGDEMIGHFCGNGTTSASSPASAIAQDGGGGGDGGGGGGGGGDPNTNAIDRQPMSDERRQLQLFRRLRIESIEATSLTGLHPGARLSSYTDIFLEPMELKTYNLTFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU10</accession>
    <name>A0A084VU10_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome bd-type quinol oxidase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009044</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525097">
        <property type="protein sequence ID" value="KFB41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009044-RA">
        <property type="protein sequence ID" value="ASIC009044-PA"/>
        <property type="gene ID" value="ASIC009044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009044"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009044-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9262" checksum="AC6BAA43967E74AB" modified="2014-10-29" version="1">MFSNVHPAQRQVTLTASQQPAGSQPISGDGAAANDTRKREGGRKNQVTGQNRASTSERERVGDETENVNYPIKTISNSGWTSSSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVD1</accession>
    <name>A0A084VVD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009487</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009487-RA">
        <property type="protein sequence ID" value="ASIC009487-PA"/>
        <property type="gene ID" value="ASIC009487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009487"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009487-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="16240" checksum="D8E4964BD6951B08" modified="2014-10-29" version="1">MKFIPEPQLSFQLRFQELSLLPDATTTRTTTTLTSAVNVQLVSRFYPVQTVRTGNRAANRPAFKPAFDSKAKAGGDGLVTPRYGTRKPPTGFGRRQTVTRERTNKRTNERDGRLVGSQERQSVVWRLLRAFAWCVLTFRFCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVL1</accession>
    <name>A0A084VVL1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000254-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009582</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017196">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVL1"/>
    <dbReference type="STRING" id="74873.A0A084VVL1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009582-RA">
        <property type="protein sequence ID" value="ASIC009582-PA"/>
        <property type="gene ID" value="ASIC009582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009582"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020991"/>
    <dbReference type="OMA" id="SHAVYKN"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="12">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009582-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="23554" checksum="DF69590565BE4E99" modified="2014-10-29" version="1">MSFFKSIPDAFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHLKKTSLSESSSDMMDLEDGVEATSGLLGEQNRMVPFLGAHLTDKHQLQQQQQNCCKQPSNGGGGLGGIGGGGGVIGDIGSGLGGVGGGGGVVGGAVSGVAIGCGVSAEGVGVGSIVGANNLQQRHNSALAVSIETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWC0</accession>
    <name>A0A084VWC0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">YEATS domain containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00009944</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017551">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VWC0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009944-RA">
        <property type="protein sequence ID" value="ASIC009944-PA"/>
        <property type="gene ID" value="ASIC009944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009944"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012556"/>
    <dbReference type="OMA" id="VKPYHNE"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
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<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX49</accession>
    <name>A0A084VX49_ANOSI</name>
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            <fullName evidence="7">AGAP000869-PA-like protein</fullName>
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        <name evidence="7" type="ORF">ZHAS_00010253</name>
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        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the PAR3 family.</text>
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        </source>
    </evidence>
    <sequence length="1909" mass="197300" checksum="C6779A109EE95380" modified="2014-10-29" version="1">MKKKGTNMFELPPKCPALADKITGIFGWRHTYQVHQRQKGIAHGNQYLYKSYSLNLPRRGGGGGGSMVSSTGSLTAGGSASSSSSQTSARERLYHRHHPHHPHQAAGSSCCATEPGTPNCEVNPDSWVVVHHLQSQSGILDPEDHISDVADDREEIIASYEDAGVGPDPGVQQGGGDGASGSSVGTGSPDIFQVGGGPKGAPGVIGVGGGGGGSAGEPPPDDDGGHVGVAADGGDPSVTVTAGVAAGGGTVMVTTGGGGSANGEGSSCIEVSANEPGPLGLGLQVRRGSEPSLHQIGVTDQRSPLYNVNPNGHHQETSKRWSAAPVCRSDSDPPPDKLNGLGGGGAGGGIGGGSSAAGYHNHLHHHHHHLLSPEWNVPEEDPQQQQLQQQPPHGQQSQQQQQQQQQHDSLLPQAFNRSGRLSMQFLGADATSGYRWMDAAEKAAAAALHNQSSPAVYQPYMQYVQQQQQNQQLNHSFHHSGVRGIDGGGGRGSGRGIAGLNNSTGSSFSSKSLPRESTRKEPLGQAKASVYDSLREKDSEMLLVVNETGGPLGLTAIPDKDRGGLLVQSVEPGSRAERGRLRRGDRILEINNIKLVGLSESSVQEHLKKSLASTELRLRVVRGGSGATTNTTTKGGSKAGGGPEQQQFAAAGRLVTGGSGSRYRRDNRVGQMMIEAEEKPTSAAKVATVSPTRKMPGGPSTASSLQVANTRKLGKRIEITLTKGDHGLGFSVTTRDNPAGGHCPIYIKNILPKGAAVEDGRLKPGDRLLEVEGIPMTGKSQTEVVSILRGTPHGATLKIVVSRQQELAENVKEREIGFGVESEPKSTTVPKPPPPVMPKSSLKQSNSSNSLAGGHHNQHPDDEGGTRGGVSGSRSMGKLSSISSPKTPTVQKKPLASILKSASTNQVADLLLLQDPPVNGTDGGNGGGGSSMTYTNGTGGGAGSLSGAAWKNREILTLHIPVHDTEKAGLGVSVKGKTGSGNSSSSGGSSSNASRTDGDLGIFVKSVLHGGAASRDGRLKMNDQLLSVNGVSLLGQSNAEAMETLRRAMLQQSGGSYPGKIILTVARRIGRPVSTGELLETMDPRPTATSSNTAATTTNPEKDGGNGGGGGGNAVSSGTTVIYLSADKQQQQQQPHRPQDNGEPKLQQSKRYSNPVLDRLTGGSGTGGNSSAGGMMMSGSNEALSSGGASALRTAGGGGAGSRGPSSAGQQTPPTHGLRNESYYMATGEHWNTTSSATSLNGSNAVLIEEDPEPTSPTFHLARPADVGGVAVGNGATSTPNGADTTYASQLSLETNPPPSDAFSRDAIGRRSMSEKHHAAMDARETGTYQRNKKLREERERDNKLLLLGGGGGNGTSMTASGGSMESISHQMARIDSLRHGGRGGGAGRQQPTAALAAHLLRDEAQDQLGDLGPSLGMKKSSSLESLQTMVQEIQMADEPRGPNALRTPRGRGRDEILRALVEQPPEANQAKKHWLLEDAPPPGAAGRGAETAGGGGPSGTELPDGGFVSRNSPFQSSLNDGKGAKLRVKKSGGLLRGIGHMFRFGKHRKDGIASMETAITSRSMMPCPPEPVGGGGPSPHGSNAWMWAAETSGNSSNGGGGAGGGGGSQKYGGSSASTKTAATSGASSNSGSNNNSTAAASRYIVFEQNSVERSASSGVVYGHQQPPHYQPPPPPPGAGSGGGTSIHHTDVFNHRYSHYVNYEELQQQISRRHHHYHSQRSARNTPPVGDIGLLGSGSVSQQHQPPSHHHHSIALHNPSHAQQQQQQQQQKYKSARPTSCYYDNPGGGYETISSIGPPLSGGGSLSSTHRKTSGSGGGGASNNNNNNNSSATSQHTLLTVSSSSANSNGNSVLPEDVNGSVSNNNWHQSHHHPGANGGGAGISTGSGSMRNTRGPFVTQVKIQNQMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXU4</accession>
    <name>A0A084VXU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cathepsin (ISS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010537</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018207">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010537-RA">
        <property type="protein sequence ID" value="ASIC010537-PA"/>
        <property type="gene ID" value="ASIC010537"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010537"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010537-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="14606" checksum="014194A5487C4EFE" modified="2014-10-29" version="1">MVDFRLCLNTFDGIFCSLRFLPLLFLAQTPKLALSPTPKDVDLTPNGHAPNELLDRRNDRTNEAAEGKNSGRTFRKTGILSIIMQMGTLLSLGISVEISGEREGGGSERTKLKTSSTPHDGDARDACVLRFGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXW6</accession>
    <name>A0A084VXW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP001523-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010561</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXW6"/>
    <dbReference type="STRING" id="74873.A0A084VXW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010561-RA">
        <property type="protein sequence ID" value="ASIC010561-PA"/>
        <property type="gene ID" value="ASIC010561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010561"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017819"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="266" mass="30327" checksum="43E5E5EB57E7D487" modified="2014-10-29" version="1">MENIYLREQITKALHCLTKSGFRNSRTSSGKYLADTIKKIGAVKRGECFGLFGMNGAGKSTLLQMLSRNVPISDGEMFLLNCEEQNSNALEYRDQYGYCPQVDSLLDFLTVYQTIDYFASIKNMNEREKHIIYWLKELDILAYKDHTVGECSASTKRKLHMILALLGDPPVVLLDEPTTGVDPNTRRCIWKCIKSIQRKGQTILLASHKINECEELCNRLSYINNGALEFIGSMLELKNKYGESFNERFQPDNNLAIDRVASFTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYY8</accession>
    <name>A0A084VYY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010989</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010989-RA">
        <property type="protein sequence ID" value="ASIC010989-PA"/>
        <property type="gene ID" value="ASIC010989"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010989"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010989-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12089" checksum="E8F2320118B3B8AF" modified="2014-10-29" version="1">MAPSDPTRPFNSDPIECTIRYGFSIFRFRQRSVPDLDGIGRLISVGSPELGATGVASHIPWETGRRDRAPTPFYFRAKNRTALAANGHFRSSAVKLGENASKLLPNHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ77</accession>
    <name>A0A084VZ77_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005532-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011053</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ77"/>
    <dbReference type="STRING" id="74873.A0A084VZ77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011053-RA">
        <property type="protein sequence ID" value="ASIC011053-PA"/>
        <property type="gene ID" value="ASIC011053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011053"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008003"/>
    <dbReference type="OMA" id="YFWIMAK"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011053-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="281" mass="30408" checksum="B5C6D5CF2E27EB5C" modified="2014-10-29" version="1">MKEKRYARSLNGKVVLITGASGGLGEALAHSFFLAGCKVILAARRKEELERVRKDLLAVHTTVPTHPPVILPLDLSDLNSIAGKVQEMLEIYGAIDILVNNGGISVRGDALSTAIDVDIRIMLVNYFGTVAMTKACLPSMMARKEGRIVCISSVQGKFAIPYRSAYSASKHAQQAFCDSLRAEVAKDNIKVTLVSPGYINTSLSINALTGSGQAYGKMDATTAGGASPEATANSILKAIARDEKDIILAPIAPRVAYWLRHFMPPVYFWVMKKRAEKLNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZA0</accession>
    <name>A0A084VZA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005514-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011080</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01018619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZA0"/>
    <dbReference type="STRING" id="74873.A0A084VZA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011080-RA">
        <property type="protein sequence ID" value="ASIC011080-PA"/>
        <property type="gene ID" value="ASIC011080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011080"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011080-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="33625" checksum="47AC24127118081D" modified="2014-10-29" version="1">MSNENANNNDSTFCQIMKPIFFVSKVSGLWPQSLQRSSPGITVLDIAYLAVLYAMFIFCILVNTNGKLWDYYMQPFGSDILRYGLQTHIVNGLYLGLVMITINIVQYKRKWEYTTLLDSITKIVEKEFYVKNPVRVVQTFIWWVVIAENVYLLLILFGYYCIIDRTLNIKTSYFYASYYLINLTTLALINEYTYFTFHIRRLFSVVNRLMKQLLLEESNSETILLDQNRKSRTPTIAYDEIFTIYGKPTKQRGSEVTRDIKRTGLPKITMVAPASAGFNKLSMDTVYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZM5</accession>
    <name>A0A084VZM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010439-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018866">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZM5"/>
    <dbReference type="STRING" id="74873.A0A084VZM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011218-RA">
        <property type="protein sequence ID" value="ASIC011218-PA"/>
        <property type="gene ID" value="ASIC011218"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011218"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001736"/>
    <dbReference type="OMA" id="NCNANMD"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF34">
        <property type="entry name" value="LD40565P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="331"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011218-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="518" mass="57279" checksum="A9F17202AC56DEEC" modified="2014-10-29" version="1">MGSRAQSVICDKVLAGLPQLLDDLQKLSEDQDTADVAFVLGSGEERVYAHRIILMARCKSFQNTKRGEICRIPGCTVSTSAPGTPTPIRLPHIEPDIFRQFILYVYTAKIMLQDSKVFEMMTLAQDMGVEELKIACEDHVSKTMSVANACTFLTAVMEIQEKASGAKCAAPFLEKCITYIAENASECVKTNAFLNLTKEGLIQVISYDNLGLEEEDVWRCVLAWAKNQAGVTQPTAHWTEEERQRVCQYLAPVISHVRLFLIDSQVFAEEVEPTGAVPIELSLERYRRAALHSNKLPTVTATAVPVPSGPLTENDKRLQPRLMLNLFHGSAILKNDKIHFQGTLNGWYGASKQTWRMVYRASTNGFAASAFHRHCDGVAPLYIIALGSNGAISGGFTDVAFAKTNRKGGYLHSEKAFLFALNSNNESPAKFDIVKKPYAICYHPDCGPIFGAGADLLISNNCNINMESYSNFPHSYDGPNSMFGHLFGDYNFSIIDYEVFTPAPTSATAANKIKHDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZW6</accession>
    <name>A0A084VZW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP003128-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011372</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB43510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC011372-PA"/>
        <property type="gene ID" value="ASIC011372"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FERM_F1_FRMPD1_like"/>
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        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
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        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
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        <property type="entry name" value="Uncharacterized protein, isoform B"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Band_41_domain"/>
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        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
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        <property type="entry name" value="FERM_2"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
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    <dbReference type="PANTHER" id="PTHR46221">
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    </dbReference>
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        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FERM_3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        </location>
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            <begin position="92"/>
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        <location>
            <begin position="227"/>
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    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="812"/>
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            <end position="1178"/>
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        <location>
            <begin position="1196"/>
            <end position="1253"/>
        </location>
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        <location>
            <begin position="597"/>
            <end position="606"/>
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            <begin position="835"/>
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            <end position="1224"/>
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        </source>
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        </source>
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        <source>
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        </source>
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            <dbReference type="EnsemblMetazoa" id="ASIC011372-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1467" mass="160562" checksum="6EB5FD5066BF3CA6" modified="2014-10-29" version="1">MGHPNIHSNKLLFVNYYYCDHTCCAKQGHITRTAGWLPPIENWVQTNDLPYGWEKAIDQKGQPYYINHLNKTTTYEEPIRHHGNDSPPEPRVVILQRSPTLGFGFVAGSEKPVIVRFVTEGGPSVNKLEPGDQILAVNGEDVKDAPRDHVIQLVRNCETSVTLLVCQPQLYNAVGRKSTLLSAGKKAKLKSRPIRVRFAESVCVNGAPLFPPSAFSLGDLCVPPMANVLKVFLENGQTKSFKYDSTTTVQNVVTSLRDKLCLTAGEHFSLVVEHVKSLKRNKLTLLDPQETVARIAARPGAHKLRCLFRVTFVPVSAAGLAQKDLNALDYLFLQCCNDVTQERFAPELQPEVALRLAALHMHQHALANNISPAKLTVKTVEREFGLDRFVPASLIEGMKRKELRRLLGHFLKLNSQMTGSSTKMLTQLQAKIHYLDIISGLPSYGAKCFSTNQRDGVERVLLVSPRFGLSQIAGVRNTVPQPICNLEELIRVVVTRDDDISNTVTVFITPDRVINFSMEDRDASEFAIVLAGYYRLMAGKELPLEQERDVQIEDIAPPYLSQHTVVSNGWSYLPTEKQTHSIAFLMPPPYHSTGFRSATGSISSSSRSDECDRNANSARMSNRNVRPSLKEYDFETAQKQGKDARVSKDGTMVGGVGRLPGGIPEARNEEVLRRVAEMQKLVENSERYLNEHGDYGHEFEVKPGGKLNFWRETSVDVDESDCESLNSSKQSSTEDGPGVLKHSDSLTLLTETINQGLDGIAKGLSSIYTAPFSELNGKLDHGGSGSAQNTPKSQRKISGLSQILSDLQALGNDLSQSESDSESLYTPNSSPIHKTQVNQSLQQQQQQQQQMQNSTQRNKSIRTSFGLHSPDSATDGRDMNLKDYLRQLKEASSASELGSDGTDLAAKKLGDLYGYELLGDDAIIETDPDIIDLRSIPPPQTPDELDNLHVLSVPPSGFDDRAGKPSGPIAAATDAVSSTGDLEEFLKQSEQQKSTEPPNLALPPKPCPHTAANQPSPPQRPPKSAELQLRLGSPVRSPPYYARMNGMAGTGNYYEMDPPSLPPRFEQSPTPPPSVILATQLPKKPPLPPVPLKPCLLRSPVPILKNPHAQTFNHHQQHFQHHLQHYQHHPAHSTPPPHLPHHLQHHPHHPSAAGGGSLSANSSPVRTAGIGSPHFHRNPNCYREIERAFNHHRDDLGAGQTTQMTPAPTTGTTTTTTTSTTMQQDNKHQLQPQPPNGHHRSHSDCPPVCLKNPPADSRAQLTLLCSPQMSRKASLPTATGPPAPTGNVTFSNPGSPILSNKNGHVLNVDTLMAKTDVAMAGLLVKLDQVAALCSAAQTAGGGSSIDEDRFQQAKDELTDQSLQLVTASKHLVVSMSDANLTNLPEHLTACLSALRRITELAQDLTRYTSAPLQTRNIVLKIHDVASSFRELACVRVGPAGAGQLALNAECLANVLATLLRSLRVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W046</accession>
    <name>A0A084W046_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP001238-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC011527-RA">
        <property type="protein sequence ID" value="ASIC011527-PA"/>
        <property type="gene ID" value="ASIC011527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011527"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009788"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015668"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021905"/>
    <dbReference type="OMA" id="NYWASRR"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13261">
        <property type="entry name" value="PH_RasGRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="274"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="678"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="1360"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="824"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1245"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="884"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="969"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1604" mass="180740" checksum="36F88A75312B39F9" modified="2014-10-29" version="1">MQRSVRVNENQLIMLSDRAQYDHSMHGYLHKRTSDNNKWQMRWFVLYQNLLFYYESEQSSRPSGLIFLEGCYCERLVSAPSLSGPPISANAGHASKIIKEEKLQHCFTICYRRENQRQYELRAATESECSAWIIAIREASFNKLLLQKEELEQKHVHLLQVVESEKTAKWQYTQQCEELASEIRKLRTEICVLRKETRSSYSATPVGRGSFSVPADSQDDHGSLPGLCASVQDSIELRKIKKVQSFFRGWLCRRRWKQIVEEYIRSPHAESMRKRNHLVFSMVEAEEEYLEQLEVLVACFLRPFKMAASSKRPPCSHEDVNSIFLNSETVLFLHQIFLKGLTSRLESWPTLVLGDLFDMLLPMLSIYQEYVRNHHYSLQVLTECKSNTNFATVLKRLEAKPSCQGRSLETFLTYPMHQIPRYIITLHELLAHTPHDHVERKSLQNARQQLEDLSRQMHDEVSETENLRKNLAVERMIVEGCDILLDVNQVFVRQGSLVQVPPGRGRIRSRLASFKSERDAVRQCFLFSNHMIIATRTSGGRLHLLPDVGKIPLADATLVEDPSDVQHDDEEASVCSASTRGSTLSVTESVNAGNRDFKILVESKSGARHGIHLVAPTIQDKEAWISDISQCLDNIHMHSLLSPGIGGSSGGHQALRADPRLFKDDVDIRFSRTLNSCKLPQVRYATPERLLQRLTDLRFLSIDFLNTFLLTYRVFTDGETVLNALKTVFTIHRSNRRVTVNIKRTFSNCRTRTGVPLHVAHRVQAPFPVRYCSEGADRDRSMSGDSTGLRFRGSRRGYQNHQSAEQETLSWIPEQVGPVIVHSAHHPSEKQEEKPIEPTGGTVHLQSKSQHQIHHQPQDDSYLVIPKAMPGSSSSDTLTETVMSGPSSPSNLSSVTLVGSTGSGGQDKSDDTPTEGTFKYGKAPTSPLPERINLKVHAKQSYTTTTPPTPTICTTDTTQTEDDQTPGKQAIQQQTCQEQQQQQQQHQQHYLPQHQQQQIKLPPTPPTVTTTPCYGASNGQSPNGHHPLQEQHSLPSPKPEQATIVQGRLEYGGPKIVTQPYLTTSTTPTTTVTITTTTPATSAKSISPPHLLPTDRRPSVGHNIAIPHAALCQHRHSLQLNGDGSLFSKSEKTSSSPRLTTRKFSAPKTPERQRKSLFGTPQRDRDSSSTRRFSESDDDMATSIFTTPRGSLGGVSLNTISSRASMQHDHVPHCSSKVGVVITSYRQSQRRSSTSTAAAAFAIATSASSNPRDEPPEVEARNRKESVVSSPATMRVLNVLRHWVSKHFQDFEQDAALRSQTIAFLDDITCSPNLLPTEHRAASQLLRLLCRDDIDSGKQQLEILLTPPQTPSKESIETLSALEIAEQMTYLDHQIFLAIRSEEFLGQAWMKSDKKSRAEHIILMTKRFNDGSRLVCSEIVSRSNMAARVAAIEKWTAVADICRCLHNFNGVLQICAAFTNAAVYRLKKTWDKVPRTIKSTITKLQAVVCSDGRFRVMREALHRCDPPCIPYLGMYLTDLSFIEEGTPDFTPDGLLNFSKMRMIAHVIREIRHFQQTPYKIDHIPKVTSYLLDTSLLLDDDELYHKSLQIEPRSSRLSAPNTANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0G8</accession>
    <name>A0A084W0G8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Calcitonin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011444</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0G8"/>
    <dbReference type="STRING" id="74873.A0A084W0G8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011444-RA">
        <property type="protein sequence ID" value="ASIC011444-PA"/>
        <property type="gene ID" value="ASIC011444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011444"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003813"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
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        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011444-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13862" checksum="D263B72AC191B53F" modified="2014-10-29" version="1">MIRDILEPMEANAGNANESLFTALDNIGGEGQTAGNGQDERIQFNRLEFESPADLMRHLYYTCLRSNVTEKPWELDDNEKFCPRRFDGWSCWEATPAGTVAENLCPKFVLGFDHRRLAYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0G9</accession>
    <name>A0A084W0G9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011445</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0G9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011445-RA">
        <property type="protein sequence ID" value="ASIC011445-PA"/>
        <property type="gene ID" value="ASIC011445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011445"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="51" mass="5419" checksum="DE2ED7954F58D909" modified="2014-10-29" version="1">MPVNSITTAVTMTPATEAFGCSAVRFNPIWEVQHGVTTIVLLVWLAVADGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0J3</accession>
    <name>A0A084W0J3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00011472</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01019122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0J3"/>
    <dbReference type="STRING" id="74873.A0A084W0J3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011472-RA">
        <property type="protein sequence ID" value="ASIC011472-PA"/>
        <property type="gene ID" value="ASIC011472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004344"/>
    <dbReference type="OMA" id="NIPRKYW"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010751440" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="28388" checksum="E8C184E3A4962219" modified="2014-10-29" version="1">MKLALFLLAVSSWRSDGVAIERSYFESYLREPPPPTQKDSEKHSGGKNALRLEYYKWPNGIVPFLFSHGFSLNEQAIILDAINVLQQQTCVYFIPKTPEQREHIRFVKSDWGCGSSIGYRRGQVEPLDVTLDDFCLGLPGAVQHELLHVLGLFHEHTRPDRDDYVEVLWENIEPAYRHNFAKGSWDYMETFGLPYDYGSVMHYPNYAYAKAGASVTMVSRINSSAPLGQTDGASFYDLQKIRYMYPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1C0</accession>
    <name>A0A084W1C0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00011845</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525266">
        <property type="protein sequence ID" value="KFB44014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1C0"/>
    <dbReference type="STRING" id="74873.A0A084W1C0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011845-RA">
        <property type="protein sequence ID" value="ASIC011845-PA"/>
        <property type="gene ID" value="ASIC011845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011845"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023765"/>
    <dbReference type="OMA" id="SWKVLTC"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="488" mass="55913" checksum="87A3B0F39C37B632" modified="2014-10-29" version="1">MHKHSITKLPSMRYGHIAPKTQWGKVSTIFYAILGIPLMLLCLSNIGDIMASSFRFLYWRVCCYVCTREPKRSNTRRGRSRGTIRQGRSSLRSNQGPGTNLRRSVRNSQRSADSGFDPYYEPGLSHSYSESDCRYNSNIEDHYYPDNDRGMRQPPSKYDPQSSNGPGGMRQKIRGPHNQEEIMNDGYQSGHQQMKRPPPQSRAETMGLDHSQRSLQKSRPNDASYRKSPGMRAQSLDRRMFRQDSQMIDMDDESPCKTPILCNKYAIDEVDEIGRPTRPNPRSQSMPRQARYGDSLMPDRMPYYTEDNELAEIQTVRKSVPRRREPRPLPAPSPRIMSPMGFAVHRQARHLQNVMDDNSLYDDEWDMQSGELPPPSIVRPVPIWLCVFLVVSYIIAGAFMFSEWEEWSFLDSAYFCFITLTTIGFGDFVPAQGVKNDSEISIALCSLYLLFGIALLAMSFNLVQEEVISNVKSVARRLGILKEEEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1H9</accession>
    <name>A0A084W1H9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">30S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011905</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525268">
        <property type="protein sequence ID" value="KFB44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1H9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011905-RA">
        <property type="protein sequence ID" value="ASIC011905-PA"/>
        <property type="gene ID" value="ASIC011905"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011905"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011905-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12900" checksum="079AAF7AF86DED74" modified="2014-10-29" version="1">MHYAYNRRTPVESGGNGKRTRRLFAEWAFGVRREAPGRGDSVFKHSEADLPNALPMEMRPRNTPEPLELRMNDLENIRKNSIPDGALFKFKSTHERAGIRDTARKNEDYTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1R6</accession>
    <name>A0A084W1R6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">omega-amidase</fullName>
            <ecNumber evidence="3">3.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nitrilase homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00011999</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:32963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16769"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:32964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxosuccinamate + H2O = oxaloacetate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57735"/>
            <dbReference type="EC" id="3.5.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:59413"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01019415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1R6"/>
    <dbReference type="STRING" id="74873.A0A084W1R6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011999-RA">
        <property type="protein sequence ID" value="ASIC011999-PA"/>
        <property type="gene ID" value="ASIC011999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011999"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015970"/>
    <dbReference type="OMA" id="EFFGFPC"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB44160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="276" mass="30872" checksum="E99141CD9B5AF3D9" modified="2014-10-29" version="1">MSSLRVALVQLKGQPTKKECIANAAAQVRLAKDKGARLIILPECFNSPYSTAEFAHHAEEIPSGVTSQALAKLAGDLGIYLVGGTYPEREGTKLYNTCPVFGPKGELLCRYRKMHLFDMDIPGQCTFRESDALTAGDQLATFTIGTLKIGLGICYDKRFPELTACYRQLGCDMMIFPSAFDPYTGPLHWDLLGRSRALDNQMFVALVSPARDPTTEYVAYGYSLLCDPWGRVLCRAKESQETIIQDIDLKVCEQIKRQIPILKQKRIDIYQLFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W280</accession>
    <name>A0A084W280_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012349</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W280"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012349-RA">
        <property type="protein sequence ID" value="ASIC012349-PA"/>
        <property type="gene ID" value="ASIC012349"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012349"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012349-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="18245" checksum="CA065BC0C8FB71B7" modified="2014-10-29" version="1">MDIKESKMLPHLLQPPLVMMMMMMVPVSVSAGGELVPSGPIIKILSHLTKHGPRPVQVVHPDRRSMGSTRYRRWLLRVRAFLPSFSRARKEKGSNRLSCPAAWNQTREVDADAASAAAIDIELIIIFPASSTLRSPCRTSGRLLPSADRRVIFSLLDDCNYNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Z4</accession>
    <name>A0A084W2Z4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012471</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB44588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Z4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012471-RA">
        <property type="protein sequence ID" value="ASIC012471-PA"/>
        <property type="gene ID" value="ASIC012471"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012471"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012471-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="7099" checksum="C8483A91F84D05CA" modified="2014-10-29" version="1">MHQHRYDLVLIINRLFAEEETVLGPGETPNAKNLSQCFPCQCFRFPPPPPSVMYRVIVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3C0</accession>
    <name>A0A084W3C0_ANOSI</name>
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        <submittedName>
            <fullName evidence="3">AGAP008173-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3C0"/>
    <dbReference type="STRING" id="74873.A0A084W3C0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012608-RA">
        <property type="protein sequence ID" value="ASIC012608-PA"/>
        <property type="gene ID" value="ASIC012608"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012608"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003054"/>
    <dbReference type="OMA" id="ERDHYCE"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012608-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="241" mass="27561" checksum="F0CA548E4BAF0755" modified="2014-10-29" version="1">MTSLQLQRVHIGKLEMDWSNHLQHFSSSRAQIGFVDWLQNLTALKSVGMSHCRLESLSLDLFRHAPNLWAVELLHAQIDQLHFPEERHQCCGNLTDLNLSYNNLPSINLTQFSELSSLKWLSIAFNRINQMLGALTTDSLVFLDLSGNQLTTIELCQWNATSLTKLHLSQNRLSHMFRCVNRLEALLYLDLEGNSIAKVDFAVFAKNSLIRLNLAFNNISEVLNRQSIARDTLVIMDHHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L3</accession>
    <name>A0A084W3L3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3L3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012716-RA">
        <property type="protein sequence ID" value="ASIC012716-PA"/>
        <property type="gene ID" value="ASIC012716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012716"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784135" evidence="2">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7616" checksum="A052D65BBB48F082" modified="2014-10-29" version="1">MCCAHALALLVPILSHLGDDCDFILDHNLNFTEDNTGARFGMLRLAVIGLIGKILILSAPTMMAMIVRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W459</accession>
    <name>A0A084W459_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006059-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00012940</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W459"/>
    <dbReference type="STRING" id="74873.A0A084W459"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012940-RA">
        <property type="protein sequence ID" value="ASIC012940-PA"/>
        <property type="gene ID" value="ASIC012940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012940"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002799"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011147"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024476"/>
    <dbReference type="OMA" id="PECPRKQ"/>
    <dbReference type="OrthoDB" id="10037824at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000065">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056707">
        <property type="entry name" value="DUF7805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF8">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25090">
        <property type="entry name" value="DUF7805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784345" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="233"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012940-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1176" mass="130265" checksum="83D31CF236B24B7F" modified="2014-10-29" version="1">MITKAIHHSLLAALALALLGVCYGCKISEYPCKGGASCVPLDKYCDGRDDCGDGSDEPKMCTVCNRTYYGDIGRTYTLTVPPPQWNRLPFLCHLTFTASGHEQGDIVQIIFDKFTVGRFDEGLIDPDMDSSDASLTSGGDLPGCPEGFMQLSELGRPFTGGSWCGKASGHQLYFSETSTVTASVKVFHAPMQAGTPFEFRIRYKFISQSEAIVRYGAPSELLELGRVTPGTYCTRQYDECYRKKCRLQSPNYPGMYPRNVTCYWTIRQKVVPTCKHAMVAISQENEHKALVKRSIASLNKTARAVRAWSDCTGERDHLIFYDGSSTNDPVLAKYCGGDWLPRVVSRGPEMLIAFHSSPFSAPLQSGQSNRGFELDVDILFADSDSFDFAQGNKCEFHINASNPDEVLLSRRGRMGHLLSPRHTLAPNTTCTYYFHGMPTDLIWISFTHYHLQILQPSGSGDNSTMGRNESPLPWITRTRVWDSAGTFVPVRTTSPTSILSTGSSTTAYGSTVGAATALLPGLTSTTALYQQLMNRTVNNYYAAVNQNGKSLKINVDNVWNPVDQYIYGPTVNSIFNQPAPTAPSDGIRGRGSGYGSSGYQEKYSKHKGKSEMGAGNYVQSVRHGKDSSSGGSGNELSREHGRKDRQSSKSSLTSRRLMAEFFDNEAPKLCDHMTVESKGHRMRPCTPLESYVSTGRDLKIEFHTMTGTSLFPSSFGINYEFVDTELGGEPYLGTDASIPILCSRVFRKRKGDFQAPRNVFLHGRGGAKNISCLYRFEASVGERVRVELFNVSFGEFATCVTESDGHTGRARCSPSESEADSRIGELRIFDVPYPDVRIPLGCFCDNTSSTYNAPLTFISNSRTLELTFIVTRLNISEDFADVYFHAAYDFIRVPECRRRLRLRGSGGEDEMHFPLKSHDASCDGLPWYIEAQQQDRSLFVRTWGSFLAVEPTAEDYSKCHTRNRLIVYSGVPLKIMRVICPSTPSGRSSALHIFSEDWLSNQPFLSFDRPVSMVLEPILKEQGSIGFSWLEIQRTKASLIQQLDLQTNFTANDTLVEFGLYPRENECEYRCPELDACIGSALWCDGRPNCPSGYDESEQECGSRLIELPGGIYAAFGCVAAAISACLIFCLLVMVKKRRKANEKLKPAGPGAGASLNGTLSKKDYKKEPLFFDPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4J6</accession>
    <name>A0A084W4J6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Fimbrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013094</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4J6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013094-RA">
        <property type="protein sequence ID" value="ASIC013094-PA"/>
        <property type="gene ID" value="ASIC013094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013094"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6526" checksum="9BA4BDC667D4630E" modified="2014-10-29" version="1">MQGNARRAGFKKREKGSNCTLVQDVYLHRQPLEARGTTGRLGADRAADNVDELLEKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Q0</accession>
    <name>A0A084W4Q0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spatacsin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W4Q0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013157-RA">
        <property type="protein sequence ID" value="ASIC013157-PA"/>
        <property type="gene ID" value="ASIC013157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013157"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021214"/>
    <dbReference type="OMA" id="MECVPVA"/>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008088">
        <property type="term" value="P:axo-dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1849"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1868"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2098" mass="238014" checksum="563DAB33B9257A85" modified="2014-10-29" version="1">MAPGDSLTPEKSIIVKGWEKLDDDVIIKEVSTKGKHVNLCIQYLAERNELSMTEAKNYFLQKVNAYVYRLLSSRQLHKAHHVLKNIERVPKYVFYQIAAETNDSGLRDYIREHLARTVESYNDGEEQRIAASWRVYTQLKANVRQMAEVLNEVTSGYTVLEIETMSFNTFCMKEDVYRNSVAVDLFFKNQETEISPILDRYTVWSYLLKNNIANLVKIWIQLNGCLRRCFQQGVDPTPHLLRIKIDIYDDPRFNERLRQLFQRWEIDDFMLSQLSHHRSLSRNEILLNELARLGKFLDHERQDAVAILRRLFTTESYKQNREWTEARWFREQITRRLVENRFFPLLGLSIVSQEVLEQLANDPTGQHRDEVNVFLQLQKLQDATINAKQLLEVSRTTSNYILTHNRAFYEENPIVYLFEYGLDEGNTRFDENNPLLAKLPHLNNFIKRNKQTQPSHDAMVKKLLAIAGIPDPAKIQQFLFYGTRTDANGAVEEEDERAARMELLEQYGTIPHFNHPLLVERYGQPVTLRYTHYIGLHRACYAVYEFYREQLQNYSQISSRQINSAAQTVAQMAIGKYWDQELVTHAVAFMEMIGVSSVPTRAYLRCLSLIKQEGSGSGPQKLTISGLLHRCEQAIADKSVDDPELLIDLEAMTLVARTNGLPYPEAYLRERLLAHDDWYRFLLLVDYLNYPPEQVVELCRTGFHTARIGKNLMLALLYQLKDGDSIRDIPPISSSVGSIKRRSSLTPRRRRRASSTTADSSGHSSVSSEGDAISSGGRTSGVTGSTPPTIGAGSVDENSCHDGACFLSERYDTDLVSTVLLCSNEPNSASPPSGPITSADQFESFARLIVTAGTSGSHRVQRYPQTYLNLLDRSIRSRWPLLALLAGEICPPECRRHCWIVWTMLAGDYPFQELLATGGRDGSVLEQDPKQAERSFVSGLVEHLVRTGRICTLASSLAIFYPRSNWHYLASFLSVTEDVLFDADRASDLFTTFLVSSSTGEECFLLRIPKYEMFNFSARLLMIHLSNRASLHHQLLLLRAYVRCDFRCFLIAEVDFGRMLRICEIVRHCQSITIDFHALYERSCAGKEQESEFYEALCERLVKRKYHEAAIAVADEASLPRESIIFEHWVSAFEATGSVGDFERYRVDSERYGLGPELRISFFTHIANRLEYGDRQRYELLRCALELIREHGLYPSETFDRDRLEYELALSYVRCTNEDTLELYRSQYWCNRRQHSEASQRAGQSTAILYHTFLELKEAAGIDDLTLSNLPLAQPEERLRLDALINRLLDCGDIVQALRYQAIFEQRPIDLHFIVFCMALSEGLVSFYNLSKEERMLLNEDRARSAGRFQRRTLSRISRVSQSSTTGGRIDGSPMKSGAGATQLDTSDTSTAGMSDFEEVPSRDRQDIFEAISGLGNRITHGQDLAQRVILTYRVAMYLDRDYNELLKLRDPLAFLPEIVREDCAHKLEVISDIVTATRMSVESFTDFLASEIVSSVVRSKFYLFQQQNSQQQHQHQQQQQAGMKTDELLWGYNIDREFHLFLELAPNTTALGNALLRYCNALRLYRKRERKDTAQSVQDALESFETIPSLRSTNDVAVLVDRLDEMLQRQVLSLKKQNTIIVALLVKAHDCFVHECSMEGIMEVLACCKALTAILTAAKSWNLIVRLLVGIGRYRDMYYCFETLIKHEQFESLLGQFDDRAANGRRLQSAIIAYLNEHCPERKDYFRLAALHFRMHKEIAELWETEAQATIHAILETYEVKQMVPLRGMSMGSVGQQTPIPSIVYCQQLQATALVQTELTSAMDAYTHAAETYLLDNNLTLAQRAAANAELVALQIYLVRQAIATERGTTGGGGSNSSPSVKRTDRSTPTSSTSTEPTCLCTSVLNIRSSEPDGRRVTVGSEITGTNGATGTLLYYINFLLTVPQTLIVARAYNIEVNWAGAIYQHYVIRGEKSYLEDFLERLPVTDAMIETLVKIFQLEPHITPQMEQAIERFIGRIQSVTLKYRLASLVGLRKTIHDLINGGAVYYLKDTNYGKSETEQNVGGGSAGCVTSNTGASAGVGGTTGVGGCVSMTSSIIGSSSIASNTSPSVNTMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W522</accession>
    <name>A0A084W522_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013263</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020456">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W522"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013263-RA">
        <property type="protein sequence ID" value="ASIC013263-PA"/>
        <property type="gene ID" value="ASIC013263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013263"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="129" mass="14307" checksum="BABC5C8599A6BC57" modified="2014-10-29" version="1">MPLLELLTVQKDSHRSGGRKMVTCTRLQFHPLANPPLCAASHHKLTSSDRRQPAVIGNDAILCQRIFLFLETHRGGPIDSGMRTQRGGSNCDRDPSPRKLPPVTPPGPVVYYFLRQSVVPDISEQSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6B8</accession>
    <name>A0A084W6B8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">FAD linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013736</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020776">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525307">
        <property type="protein sequence ID" value="KFB45762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6B8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013736-RA">
        <property type="protein sequence ID" value="ASIC013736-PA"/>
        <property type="gene ID" value="ASIC013736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013736"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7655" checksum="A92D7DA967BCA323" modified="2014-10-29" version="1">MRELKRIMMAYEAALPPATRTLDLSRPLLASEGQPGMIRKNWRNEMHLVSMKGDPGRATGRHNPLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7U3</accession>
    <name>A0A084W7U3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Alpha-2-macroglobulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014273</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7U3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014273-RA">
        <property type="protein sequence ID" value="ASIC014273-PA"/>
        <property type="gene ID" value="ASIC014273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014273"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014273-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7046" checksum="CD456359F682B178" modified="2014-10-29" version="1">MPLAKKPRSGKEQQEVGHLQCASEPIMVRIPLNQAKDKDQFQPVARRADDLCYPDVSRGERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W822</accession>
    <name>A0A084W822_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014357</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W822"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014357-RA">
        <property type="protein sequence ID" value="ASIC014357-PA"/>
        <property type="gene ID" value="ASIC014357"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014357"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014357-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="12062" checksum="F1BFE35E8B95B24A" modified="2014-10-29" version="1">MARCTRLHTYKKRVTWVTTTITTNTRIILPAADTTLLVRTTWLNFIYMFVFRALIDECVVSVPVAPRVVLLIQFGGKFITYEAFRGRLTGRCGTDKWFVVSGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W825</accession>
    <name>A0A084W825_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W825"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014360-RA">
        <property type="protein sequence ID" value="ASIC014360-PA"/>
        <property type="gene ID" value="ASIC014360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014360"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014360-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11689" checksum="B913F32640C89879" modified="2014-10-29" version="1">MSLILVSFVNLKARPYVNPEEKKQGHGHPLMQSSAGDDRRKSMRYETDNGKCVLSHQTQAPKPTHTHTCQTAARRETVTGRGNNTKEKESERIRKATGEWNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W849</accession>
    <name>A0A084W849_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00014389</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W849"/>
    <dbReference type="STRING" id="74873.A0A084W849"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014389-RA">
        <property type="protein sequence ID" value="ASIC014389-PA"/>
        <property type="gene ID" value="ASIC014389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014389"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010912"/>
    <dbReference type="OMA" id="IEYQMFT"/>
    <dbReference type="OrthoDB" id="5789657at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784619" evidence="4">
        <location>
            <begin position="36"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="899"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125340" checksum="1A587FDED7100027" modified="2014-10-29" version="1">MKYKRTTGGGLAGLGFIVVLYGCWVLVLGPPSAHAEYIPPGPKYKCPEKVKLIYPCVCTHGTDDGLFVQCENSNLASLSVAFINLASMNLPIVELRLKRCKIKNLFGTLLHKLPVKHLHVTDTPLASIADHAFYGINDTLLELHLVHNELTQFPIEALKILGMLKVLNIDGHRIESLPKGSFAGAHFEGTLEKLHFVNGPLAELGPDIFGGLKKVKTLDLHGNQLISLKKGQFKGMREVEVLDLSYNNLTKLDATHVSDLTKMTWCNVSNNALTEITRGTFARNTVLRVVNMAANAIRKIDANTFRGMRFLRRLYLSDNMISDVGRGTFGSVTRIGTIDLARNRIKKVDYQMFFQLNYVELIDLAENEITEIQKDSFKDLYLTHINISHNRLETIEPKSFINCANMTVLDLSHNLIRAIPRTAFDETTYATEWIVTHNLLTNMTQLPLANMTGLKILNVSYNNLVDIPKNTFPKLYELHTIDLAHNNISHIYNAVFQNLLSLRNLNLSYNALEKIGPSTFGTLPTLLELDMSYNRLKDITRGALAKTTGVRFLHMQHNKLEKVFQIPISLNELNLAHNEIAEIPEKTWPTMNSLLGLDLSYNRLANNLARGSFAGLLTLQRLNLESNGISEIPRDSFADLGTMQYLYLARNNITMLPKGAFGSLPILFELQITENGLNSVAERAFDGLLQLLTLNMSHNELRTVPNGAFMGLVSLRRLDLSHNLLTTLDNKTHGLLEDCLSLGELNISHNRISFITRKTFPSNPYIPYQLRSVDLSYNTMSFVTGDLKVGTGTVQHLNLSHNNIKEIRPGVLGNLTSLRTLDISHNELLRMDNDVFRMPVNFSELYAHHNKIWNASYDALLKLNNLTLLDLRANELTRFEPQLVRRMKTSNLTVALGENPLKCDCYMRPLFHYLRSLPSVGEWYRELECTLPIPLAGERLFNVTDELLACVPAVEDDAFRPLPDLRFREIAFFRGQLVINWYVAATSDVADFYVYIRDQANRIIVERTVPYTSRSTAINGDDIRPQGDPQLELCVLAKASDDAINFLDSQCVPLPADLDTIKRQYNAQYNYKYPLNLARASANSGASCDKCVPSVAASFGAAVLIIAWIRMVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W881</accession>
    <name>A0A084W881_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008134-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014424</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021385">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W881"/>
    <dbReference type="STRING" id="74873.A0A084W881"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014424-RA">
        <property type="protein sequence ID" value="ASIC014424-PA"/>
        <property type="gene ID" value="ASIC014424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014424"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006320"/>
    <dbReference type="OrthoDB" id="7760873at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="453" mass="50447" checksum="87B75B9BD02FB99F" modified="2014-10-29" version="1">MATAVSDCSVPYNPANETRPSNAEDFPNFRDFQIVKMVKHFLVITDGSKQQLRLGFKCRTCGQTFNKTMQLLGHIRLHFEDEHTCRNCGKYFFDPNKLQIHVKAKHTVATVVKCQLGCDSFQTPSYKSMQMHYERYHCVKIRMRELRKMDDAIRNGGTVMTQLVSLKPKRKRVHTPLEVRGPPSSGEESQESAEAAGTGDSTSEPMELVAVLNQADEEDDVEEEIEQHEALINFEQPEDERVYDDMQCCVCGAIFGNELQLEMHENSHTTPFECSFCSMAFRELAEIRVHYQHKHQDAGKTPHAQLAAVNPYQQTTAATLTPIQQNTQIAWPITATPITTNQHHLQQAQQILPPVQNQIEIIPLHSGPPAGTSTAGSPHGIITTIAPQHQHMQQVHHAQPQQTTLAPIHISLKDASGNVISGGPAGGGAAGEQKYIQSSFIVTDASLLTPYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8I7</accession>
    <name>A0A084W8I7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP012692-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00014525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8I7"/>
    <dbReference type="STRING" id="74873.A0A084W8I7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014525-RA">
        <property type="protein sequence ID" value="ASIC014525-PA"/>
        <property type="gene ID" value="ASIC014525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014525"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007777"/>
    <dbReference type="OMA" id="RMICADL"/>
    <dbReference type="OrthoDB" id="7729212at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0222">Digestion</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784506" evidence="8">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014525-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="268" mass="28981" checksum="03A011516BF287B9" modified="2014-10-29" version="1">MKQTFGLVFFALLFGCVLAGNKPESVSAKGTQSGRVVNGTSVSSENYPFVVSMHRYLGGFFCAASIITDKHALTAGHCLVGNIVKPADFVLIGGSSYVDSGILFFVSNYSVHPKYSVDNDTADYDAAIVTIDGTFDNFTNIAPISLPKTAINYSRNNPTWCYVVGWGRTDGKMPTYPETLQHAWMQVVSQYKCQQIYIRKTAITSRMICADLPNTSACYGDSGGPLVCNGELTGIVSWGSDYCSGQPSVFAKVDSTSIREFIKEIAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8J5</accession>
    <name>A0A084W8J5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">MAF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014612</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021479">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8J5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014612-RA">
        <property type="protein sequence ID" value="ASIC014612-PA"/>
        <property type="gene ID" value="ASIC014612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014612"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014612-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7592" checksum="6F3C377CC7F74C9B" modified="2014-10-29" version="1">MVEGNPNDSVPKSIPTRMAATMSDSVRLRFEPGQLLIRSDASSKKDAGKLSSPRRQPARSINPKTINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Y3</accession>
    <name>A0A084W9Y3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein cueball</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00015043</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cueball family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Y3"/>
    <dbReference type="STRING" id="74873.A0A084W9Y3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015043-RA">
        <property type="protein sequence ID" value="ASIC015043-PA"/>
        <property type="gene ID" value="ASIC015043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015043"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004905"/>
    <dbReference type="OMA" id="RCEQNST"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF42">
        <property type="entry name" value="PROTEIN CUEBALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015043-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="661" mass="75147" checksum="58C7693510A5EECA" modified="2014-10-29" version="1">MYVFLSAYEAAVTTDNGILFFDSNWQKISSAAHQYTRLSAFAYDEVLGKLYFSDLNDPEYRVCALEYDDKEHVNHKVTKLLPYSPETTAIGGMAFDHLERKLYWTEKTTHKIYSIEIDPLLDGAALRNQGEANVTLPLPKIVATVEQDDDLAGIAIDECRRHLYWTNSYLQRSNIVRAAMNGTILNTHEEGVYQPRGITIDHYRNRLYWVEKRYGRRYNIESTDLEITNLTTLISDLDRNPVDLAVSNGFVYWTDQENNDIYETAKNSSQQTRSVYHGEHPSAVILRANLLIDHQKNNPDCTGVIESILEKMQKSKSSEELRKKQQASGQDQVIVCLNNGTLNPNTRSCICKPFYTGKFCETNVCQNFCLHGSCTMGRDNKPRCECESPYEGIRCDQKPCDGFCLNGGLCQSKSATERICQCDSTGFTGARCEKPICSKDYCFQGECVVDQNRQPTCRCPAGYRGKRCEENSCNDHCMNGGKCTLNNETVPECQCGDEFAGKRCEIPVRLCEHPQWKQQCLDTAKTLPQMEPKVTYCKESFNRTVVYTSLCFTVSFVLLLIIVLTVHRMMKPPRPRITKKMVVTPMTSRPPTTQCEITIENCCNMNVCETPCFDTKLLKNSPKKDDKVYLLEDIEDVGGSYRKLHNCDDGSEKFNGSSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA63</accession>
    <name>A0A084WA63_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00015155</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022047">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA63"/>
    <dbReference type="STRING" id="74873.A0A084WA63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015155-RA">
        <property type="protein sequence ID" value="ASIC015155-PA"/>
        <property type="gene ID" value="ASIC015155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015155"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012951"/>
    <dbReference type="OMA" id="CQGDQGG"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF136">
        <property type="entry name" value="GH06673P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784767" evidence="3">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="44"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB47107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015155-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="380" mass="41043" checksum="7A19929C5641CBCC" modified="2014-10-29" version="1">MKNLHVCLVLSAVVTWTACLANPLEAVHLAGKRVELPVHKTPRIRGGIPVGPEEIPYAVGLMIQQPIGNRCPGPTTVLLGASNMNDVEDIVMANAVILHQAYVPSQNLNDIALVQLSRPANISNYVRLARLPNWRQADSLFTNQLATISGWGALGQNAPEVLPLNNLHRVDGAVITNTACNLQFLGGIVESHVCVASSNGSPCQGDQGGPLTVQDADGHQTVIGVFSFITWLGCDANWPAVYTRLTPYLAWIEANSDVTIRNDFEFFPTPPELQPTTTTIASTTVTTEEQTTTSLETTTQPTTTTIASTTVTTEEQTTTSLETTIETTTLETPTVTSGEPEMTTPQPTTETTVDPELTTVQPLMPPHRTGRPAVRQHHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB26</accession>
    <name>A0A084WB26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011398-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015361</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB26"/>
    <dbReference type="STRING" id="74873.A0A084WB26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015361-RA">
        <property type="protein sequence ID" value="ASIC015361-PA"/>
        <property type="gene ID" value="ASIC015361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015361"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003194"/>
    <dbReference type="OMA" id="RYNDQFA"/>
    <dbReference type="OrthoDB" id="6622877at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033545">
        <property type="entry name" value="CEP89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36170">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 89 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36170:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 89 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="458" mass="52953" checksum="CD0074750E969883" modified="2014-10-29" version="1">MTHIGTVVGRSKSVDDLTSVDDIERDDGKRLSETTAGGPELEKLLRSKDEQIAKLVEKLSTVFECNNQFAVEHEKLQKDYQQAMQNLHTLQGIKAKSCDQCASFETERDQLAKENGDLRNDVKMMKILVYRLNVQIERYQDAIREGTTAKNAIPRLDFVDSTYGGAKDNLNWGPVNSHTLGPLLNAYEETIAEKSDLVQQYESELVGFTGKLKKVLEENESLQQEMETMRAAQAGWTSERTRLQAQVDVLRSKADVQGKRADLAKEKLVEVLKCYEQKVQAQSLDIQRLQEAYSRSKGELATLRNLNHNPELVANSLKECQQYDLTQKATELEQLRNDYQQQLKIFERQKEINEILMGKNAALKQTLERTRQSKEILKQRLKTMITWGKGSEQRKDQLQESWQTIRALQAQLQQRDGQLRSLQQRYQTEVEQLERRLRQREDTLRKILAEKAQFHRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBI1</accession>
    <name>A0A084WBI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015542</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015542-RA">
        <property type="protein sequence ID" value="ASIC015542-PA"/>
        <property type="gene ID" value="ASIC015542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015542"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015542-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11287" checksum="95D3536A7BC4ACFC" modified="2014-10-29" version="1">MSRSRRVLQELPCGIPINNSLSSWRRKEPLANVDARQRRHDAVCVDRRAFRSFDWPWKVGKSIGRGQGTVPSMLMEFMESIRTRSRCSCGARGGSPRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC09</accession>
    <name>A0A084WC09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">SJCHGC07392 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015822</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015822-RA">
        <property type="protein sequence ID" value="ASIC015822-PA"/>
        <property type="gene ID" value="ASIC015822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015822"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6470" checksum="24AFE2E298F8F7C8" modified="2014-10-29" version="1">MSTHSKAAVLLLRELPVRDLLHLPLTSHVLPQWVGSPTIRRDFQTLLLALGKETAVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC37</accession>
    <name>A0A084WC37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015853</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022555">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015853-RA">
        <property type="protein sequence ID" value="ASIC015853-PA"/>
        <property type="gene ID" value="ASIC015853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015853"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7429" checksum="02192F588B72A6C4" modified="2014-10-29" version="1">MHKSEPGEGQRGEGGKDDEGCETKPKFRSMGAEKFNGPEPTLSCVRLGHFLQEPLLIITTLERGTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC77</accession>
    <name>A0A084WC77_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009881-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015778</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC77"/>
    <dbReference type="STRING" id="74873.A0A084WC77"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015778-RA">
        <property type="protein sequence ID" value="ASIC015778-PA"/>
        <property type="gene ID" value="ASIC015778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015778"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021700"/>
    <dbReference type="OMA" id="WMLMNND"/>
    <dbReference type="OrthoDB" id="60621at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015778-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="368" mass="41602" checksum="3895FD19E72B1D6D" modified="2014-10-29" version="1">MLRSGNTTTILCEEQSKFILDRIGSVEKHFSELCGAFSEYTRKVARLRDKSDELAHATQDYCDAEKYNRTLANALSSLAKAVTLIGDFQDTGYEAVCKHCKEGVKEALLARDKDLAKRKQLEQNKNRNARYKRNTNDTEMIKSNLEVAKSLKDIEQLVERFEKQKLRDIKDLLQSFVLIELKMHAQAVEVLSATYQDISDIDECKDHQQFKKYLQQDTVPDRYFLQRIKSQSMGALNATFAGFSGGRKNKSLSSNSLNSSQEQEQEEAPGALAGVVEQQRVQRHPTSRRSNKTSVQQSVESLDSLKHDTSTESKSSSEEDDSEDSETVTDENSELAIKPMRPTVIAEPVKKGQVDSTFKIIKLKDFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCC8</accession>
    <name>A0A084WCC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015926</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCC8"/>
    <dbReference type="STRING" id="74873.A0A084WCC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015926-RA">
        <property type="protein sequence ID" value="ASIC015926-PA"/>
        <property type="gene ID" value="ASIC015926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015926"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008080"/>
    <dbReference type="OMA" id="RIQRPFH"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="249" mass="26533" checksum="5370279CF493EE40" modified="2014-10-29" version="1">MDNPSYGSAHMSSPALVVFSQATNGLSDALRIQRPFHSQLPDAKELHHLSLMSGYGAHLLHGFQPHFLHPLNPAVSTASGSSPFGGGGAFVKPFPSNLPLPSAFAPPKCLGFGIDQGLLFGSSGSGSESFRTDSSSPACTSLSPPAKDESLEGQTSEEGDRDRDRICSPERSPETPGFRPFSGHRLAHFSSQMLVLLHCPVREAVFWAQEASTPPHRTRKCVTRSFLPVAYTIVWAALKCPAKGATGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD27</accession>
    <name>A0A084WD27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Short neuropeptide F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016250</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD27"/>
    <dbReference type="STRING" id="74873.A0A084WD27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016250-RA">
        <property type="protein sequence ID" value="ASIC016250-PA"/>
        <property type="gene ID" value="ASIC016250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016250"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006977"/>
    <dbReference type="OrthoDB" id="6364308at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016250-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="286" mass="32659" checksum="179E9B86700AFA97" modified="2014-10-29" version="1">MRTKSPTPPPPPPPTTGRKVGRSFVFDFCTVFELQMLCANLTRNFPVSPKASIYFLQLTPIPSSDGHAVGTEQWKDAQADGPGSIKDLYEYLLQREYAAPVSYADHQIKRKAVRSPSLRLRFGRRSDPSMPIRPDDDDLMEQKVIRAPQLRLRFGRNDPLWSSFNENALLEENFEKRAPSQRLRWGRSNLFGNLANQQDDVMQQKTIRAPQLRLRFGRTDPSWAMYNEHQFTADPEAALTNEASEKRAPTQRLRWGRSDPALAKDLSEDNKVLDAEESETNVADDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDK8</accession>
    <name>A0A084WDK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005727-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDK8"/>
    <dbReference type="STRING" id="74873.A0A084WDK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016281-RA">
        <property type="protein sequence ID" value="ASIC016281-PA"/>
        <property type="gene ID" value="ASIC016281"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016281"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021849"/>
    <dbReference type="OMA" id="AHINVAF"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051662">
        <property type="entry name" value="H2.0_Homeobox_NeuralPatt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331:SF0">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016281-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="20947" checksum="5C78CBED711A61E1" modified="2014-10-29" version="1">MKWRNSKERELLANGGSRDQTLPNKNNPNPDLSDARTDRQSSLSPPPSSPSQGTDPQTQAPVQSPPQPPTPTASPKPPTAQPLITFKSKFELLKPSAVAAGGGGGAGGEFKFDFEDHRPPNAGAAGHFGMAGFYPPAGGERDREAALMRLSPGSGTVGGSVRSNSSASSDPNAGGGSAGGTMYYDEYDSAGDTDDSDEEINVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDW7</accession>
    <name>A0A084WDW7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023078">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016536-RA">
        <property type="protein sequence ID" value="ASIC016536-PA"/>
        <property type="gene ID" value="ASIC016536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016536"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5994" checksum="A34D9306AEAD14C4" modified="2014-10-29" version="1">MARDTRSDKSEEAKAGGKGLCWQMPSRSNRLPRLPARMMSSKRGVRGQFSPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE15</accession>
    <name>A0A084WE15_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004952-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE15"/>
    <dbReference type="STRING" id="74873.A0A084WE15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016443-RA">
        <property type="protein sequence ID" value="ASIC016443-PA"/>
        <property type="gene ID" value="ASIC016443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016443"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008382"/>
    <dbReference type="OMA" id="CSMYSIS"/>
    <dbReference type="OrthoDB" id="6253837at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="340" mass="40029" checksum="EC337FE03AB9EB40" modified="2014-10-29" version="1">MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQAEAYKKKQEELRNQYEKEQELHDNKAMLSRDSKDKLSVNFMYELPPGMKKEREQESNESEYKFEWQRKYNAPRESYCKGDTEIRDQPFGIQVRNVRCIKCHKWGHINTDKECTMYSLSMSEAKKIHSEAEANQVLSKGELEQQLRDDGLAMKRSAQELVTSHKLVTDPEVEQAVPETEFIRSLTKKQKKKLLKKLEKIEKKQRASKKKHKRRSSSSSSESSNSSSSDSEDSGTVVRSSKKKSKKQTTHKSDNRHDERREPREKGTERRDKYRHRSRSRSPHAGSSRGNEAKHSKRRDRSASPRRDRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE27</accession>
    <name>A0A084WE27_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016456</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE27"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016456-RA">
        <property type="protein sequence ID" value="ASIC016456-PA"/>
        <property type="gene ID" value="ASIC016456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016456"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="181" mass="19081" checksum="F2F9E422D325F4B5" modified="2014-10-29" version="1">MGKRKDDRTATAYNGPRKPRATPVCTRSPPWAANDRKGQKASLESLPESGSVSELPRVSGYRTLSLTPTGVFPADSTAEMLESRFSSVHFSFDPKIILPSTATGRPFSFGPGAKETTTTTITTRTTVKTNAQTSLLLGKKSLFANACSSIETGVGIPLESLAHGKVGGSVHAKSLLANRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE55</accession>
    <name>A0A084WE55_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00016622</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01023152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE55"/>
    <dbReference type="STRING" id="74873.A0A084WE55"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016622-RA">
        <property type="protein sequence ID" value="ASIC016622-PA"/>
        <property type="gene ID" value="ASIC016622"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016622"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022630"/>
    <dbReference type="OMA" id="ARRCPIM"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015118">
        <property type="entry name" value="5aminolev_synth_preseq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09029">
        <property type="entry name" value="Preseq_ALAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="5-aminolevulinate synthase presequence" evidence="9">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="165"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016622-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="579" mass="63555" checksum="C5B3FFE60348C664" modified="2014-10-29" version="1">MPCPFLTRLSTSYVRNYAPTLLKTYGAQCPVVQRTISTLQGSQGTGSATSGAEAGSMVGKEAKGTESRRNLSSQPKPEPVQQSSSPEGSKKCPFLSTASPHVKKLGVESVEVPTERTFAYEDFFHEQILRKKKDHSYRVFKKVNRLAAEGQFPRALEYSWGERPITVWCSNDYLGMSCHPEVKRAVADALETYGTGAGGTRNISGNSMNHENLEKRLAQLHQKESALLFTSCFVANDSTLFTLAKALPGCHIFSDAGNHASMIQGIRNSGVPKHIFRHNDPAHLRELLEKVDRSLPKIVAFETVHSMTGAVCPLEELCDIAHEYGALTFVDEVHAVGLYGEHGAGIGEREGQLHNMDIISGTLGKAFGNVGGYIAGTELLVDMIRSYAAGFIFTTSLPPTVLCGALKAIEILASDEGRELRARHQDNVRYLRQRLQQEGFPVEHTPSHIIPVKIGNPRQCTDVSDRMIQRFGHYVQAINYPTVARGEEKLRLAPTPHHTRPMMDEMVRDMKVVWQELGMPLGGNQCPAECTFCRKPLLFDRFESRTKGGSSSSPTASSSCAAEVICQIPNCPQIAAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEQ4</accession>
    <name>A0A084WEQ4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00016698</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEQ4"/>
    <dbReference type="STRING" id="74873.A0A084WEQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016698-RA">
        <property type="protein sequence ID" value="ASIC016698-PA"/>
        <property type="gene ID" value="ASIC016698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016698"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014933"/>
    <dbReference type="OMA" id="FINADIM"/>
    <dbReference type="OrthoDB" id="7744263at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB48698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016698-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="598" mass="68577" checksum="0C7B78385CA0E65B" modified="2014-10-29" version="1">MTLLVICAIAAIIVLLEDFTEMISNVMGTITLILHFTRMCFVIPLILWPLVNRSRSIKLCNSAIDIQIRLYDRLNPNEPIKHVGFTLLKAQTILNILVLVMNCGFFIYNFYMFPQVRKLQLVVIHYGFALIEFLISVHHVNTQIWAIFIARQLKEMVRHTKSIRQDALRSIIALSSDLDDFKKLFGSIFGPMQIVHVLNVFVMCSVQSYVAIYCLVPAIVASGERFPTMSHLTVLNIFNHLCTSVVYVDASQKEVTARRKHVLRNILPIACLIMMFAYLGSVKSLRDFNLMMQSVMEIVHLIKYCINGQIICYVVVWMYRYSGDVVRLYQDMIEMDNALQRLRPAIGFETDHHGPMKMLIALAILLRAAISAYHLVTLSTDDTPVSIDVMLILQGNVVVELILDLDKIYLVFFAIYLNKRYVCIEQMVRTNDAVQLVGTFEAFGRLLTVKERISQTLGQPMLFMVLETFVACSVHAYLLMFFAGTNAKTLLHVLANAGQLAIHFLLFYILTHFYDAVERKEAELRSALKSIQYINFKQQTGEQKDFYDLINLKLMMEPPKITACGLFEINLQIFYNVFAAIITYIVILFQFRGFEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF22</accession>
    <name>A0A084WF22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP000021-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017127-RA">
        <property type="protein sequence ID" value="ASIC017127-PA"/>
        <property type="gene ID" value="ASIC017127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017127"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003647"/>
    <dbReference type="OMA" id="TIKTCEY"/>
    <dbReference type="OrthoDB" id="6278121at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15202" checksum="015AB6363BB09114" modified="2014-10-29" version="1">MYPPKGRSAHECYVCSNQTGNTDKCLNTVKICEQGEDACLTEIRWGSTPYFSLGAQKQFYVSKRCAKKEICQRIRTKHMPYCTHIWYEDWTCSACCLGDRCNYYVISAAPSITMSTFLAVIATVGLLARTILWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFM8</accession>
    <name>A0A084WFM8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017032</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFM8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017032-RA">
        <property type="protein sequence ID" value="ASIC017032-PA"/>
        <property type="gene ID" value="ASIC017032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017032"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017032-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13022" checksum="167042BD5EBFBD52" modified="2014-10-29" version="1">MDIPLERLTADGWMDGKMYYFGLSQSEFARRHKECHGAVEKWRKGGGVGECNSCVHKARARCGKTSGSGIRMLRARCEFPTGKRMLASGGRSSTSAFARNFIVREASERPEHPEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGQ3</accession>
    <name>A0A084WGQ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00017497</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="ATLV01023664">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGQ3"/>
    <dbReference type="SMR" id="A0A084WGQ3"/>
    <dbReference type="STRING" id="74873.A0A084WGQ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017497-RA">
        <property type="protein sequence ID" value="ASIC017497-PA"/>
        <property type="gene ID" value="ASIC017497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017497"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012149"/>
    <dbReference type="OMA" id="KCPIVEH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="117"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017497-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="695" mass="77357" checksum="12AF7611CF895289" modified="2014-10-29" version="1">MTKQNLNEIDCVDEIEENLQCVGGTAGAVALTVAAAAATYYYSTRPVPEKPLVPLDNQCPIEDGPDQVHVSKFYKEAKDGKFVSYLEDDVRTLYQSFRKGAHMSNNGPCLGWRENLQSPYQWMNFNETLLRAKNFGSGLISLGLRPGPSTYIGIYSQNRPEWILFEQGCYCYSLVVVPLYDTLGPDACAFIVDQTEMQVVVVEDDKKVNLLLDKAPRSLRKIVAIKEVRPATLQRAKNVGIDVHSFDEVEKMGAINDHPELEPQPDDLCTVCYTSGTTGNPKGVMLTHANVLAGVAGVLLQLGTHRPRVGDIMVSFLPLAHMLERCCENGVYYMGGAVGFFSGDIKELTNDLKALKPTLMPAVPRLLNRVYDKVFAEVARSSVKKLLLNMALSSKEAEIKRGIVRRNSIWDKLVFRKIQEGFGGRLRLMVVGSAPLSDTVLAFSRAALGCLICEGYGQTECTAPITLTVQGDFVPGHVGPPVACNAIKLVDVPEMEYYASQQQGEICVRGANVFIGYLKDPQRTAETIDKEGWHHTGDIGQWLPNGTLKVIDRKKHIFKLSQGEYIVPEKIENAYIRSQYVEQVFVHGESLKSCIVAIVVPDVEVIKSWAQENNIPGTLSVLCNNPDVKQLILNDMTLWGKEFGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKSRRPQIRSYFAPQLEDMYKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGX1</accession>
    <name>A0A084WGX1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP008101-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00017589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGX1"/>
    <dbReference type="STRING" id="74873.A0A084WGX1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017589-RA">
        <property type="protein sequence ID" value="ASIC017589-PA"/>
        <property type="gene ID" value="ASIC017589"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017589"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009762"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB49465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017589-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8731" checksum="E34564A53C17B44F" modified="2014-10-29" version="1">MSFSDYCSARVSPSKPEDHYRAVCRALVTETLELRTFLQRVCQGEAEVLRLKAQAETTGKELEKIHFNDWLGGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGX5</accession>
    <name>A0A084WGX5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spire</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGX5"/>
    <dbReference type="STRING" id="74873.A0A084WGX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017633-RA">
        <property type="protein sequence ID" value="ASIC017633-PA"/>
        <property type="gene ID" value="ASIC017633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017633"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006844"/>
    <dbReference type="OMA" id="QNGGHRI"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55050" checksum="58320B9FF3D84B22" modified="2014-10-29" version="1">MQQNGGHRISSGFGGGAVVAGVAGGKRSSTTDDRTADSTNRLMIVNNENNQNNINTVLRRTTYDLATQCESRRASLRRHTIIGCNQSYKRDPLASHSMPPSRPTSRTEQHPPVRSEATPASTVLPSTTTTNAPAKEKPSAMVTPHTINGARPAPIGGAGGSSGGGGEYGAGTGTGSNLSSLETWTKNSLDEHQWKDTFNLNDRLSLTLEEIVHIRSVMTKAELEGLPVDVHIKEDVEKRKVCFLCLRTRFTLFARGILCKLCQRTVCNKCNTKMRIPTEHFRNVPVVLLSPSLMNSPCTSNTPSPSHHAHGTGSGPTSMVDESFPRSLMERLLRPELDRKTRNTVGSAPSSPKNQRSASSTPGTSLHGTETLSLSLSHHVASANAAKDPVPVANGGAVVASSVSAAQRCSLMSRSMEGPNSLPPQSPARPHSNCSTLDRKNRFAKAFTLTTAGGQGGGALDPQKERLTGELMAVCNDCRSLVLEIIRSSRQTRTTARNQVLRHLTLDISPVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGZ5</accession>
    <name>A0A084WGZ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017690</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023772">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGZ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017690-RA">
        <property type="protein sequence ID" value="ASIC017690-PA"/>
        <property type="gene ID" value="ASIC017690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017690"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="213" mass="23559" checksum="021B0863A136FD13" modified="2014-10-29" version="1">MAGDQKAGLPRQWAGRKNTRQVGARREQTPKRTGARGSVPVSGEIGKTKAGILRRAGEIRAKPSPPPWAHPIVGRRSWCSLPIGGSIGLNDTLWDPLAVGAQMRNESRNNSDNNNNNNNEKATRNKTTPMVNRGPKFGIKRPACRNDPWPKSIDSRFTRRANRTETAPAQRRNPRRSVLGGTRAREHAHTLACRVRGLPVLPRGRPKVAGKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHP1</accession>
    <name>A0A084WHP1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">G-type lectin S-receptor-like serine/threonine-protein kinase RLK1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018389</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB49735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC018389-PA"/>
        <property type="gene ID" value="ASIC018389"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018389"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018389-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="131" mass="14241" checksum="8BBBFF2E10D2AE65" modified="2014-10-29" version="1">MLASPKPPTIAVVQCREFAFTFPPHSPPPPNRDGYLIVSSHKSKKIVIITRWPFISRPVGESKLLFVVPLAEGLVPVPTPPSLTDIPATREPVLISLHVQHIITLLPSLGPQAVEVGLRAAFGYPACRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI31</accession>
    <name>A0A084WI31_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017901</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017901-RA">
        <property type="protein sequence ID" value="ASIC017901-PA"/>
        <property type="gene ID" value="ASIC017901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017901"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017901-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15872" checksum="C89AC7F7178B93D4" modified="2014-10-29" version="1">MSLFIIYLKLNHLKQLSPDSRGLARSLTLPLPLARRSLRHPERHGRNGPGNGSRIAASTLRYCFTRAELHARVAGRNVQYQKLISMHPSSLLGAFGLAQTQLQDQIFPLMTSARWQNAFAELVVVDVVVVVQLAQPKFDIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIA2</accession>
    <name>A0A084WIA2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012089-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIA2"/>
    <dbReference type="STRING" id="74873.A0A084WIA2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017980-RA">
        <property type="protein sequence ID" value="ASIC017980-PA"/>
        <property type="gene ID" value="ASIC017980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017980"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013571"/>
    <dbReference type="OMA" id="HREMPPP"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017980-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="329" mass="35067" checksum="E580DF2937501B28" modified="2014-10-29" version="1">MKFHPAHGTFIGSVRLEANKPTQLQINSQFSFGASTRHYILRERPTVGSRTNIMEDIPMMDTSDGTFLGLPESQTELDNLTEYNTAHNRRISMLGISDDTSTGASAGGAGGPVGNSGSNYKKNKRNKRKGVAFNEDEIIINPEDIDPSIGRFRNLIQSTIVPVSVPKRAKMEVQNSMGIVTSPSSGLKTAVFHHMTAHGQHGQSNSLVAQSLYHGIDPADGGGGGHGSSTDVRHFGSFDMDTTPSGLTTKLGILLPNPAPDVNPTPVAVRDTLAPVFAVPGSSTSGAGKSVKISEKVPEAPDEPKRKNTPRNSGPDESRSDWPTSIDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIQ0</accession>
    <name>A0A084WIQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018146</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018146-RA">
        <property type="protein sequence ID" value="ASIC018146-PA"/>
        <property type="gene ID" value="ASIC018146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018146"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018072"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="283" mass="30049" checksum="D965C5652DC08D12" modified="2014-10-29" version="1">MDDENGSAATGTISTAITTPDIGTYEGSPKSSSEQLTLSTAAGKEPTDDESAESEFGVEQQNSPNNIADPSETENSATEVEKPMDGTGPSFSDGKCIDGTPEYRKQEENVGNYETTSINGVGVEATSESDTSAEHSSHMPSSQTNEQQDLLEKDASVQHVVHKKKMSKEPKDTLSEDELSVAKDDTTLTNTDNYRIAESCTGHLDEQARFTDCPTSDAYADNCISPSEEKLANEDGNDAVRSTYNAKSGTNTALNLDGATLAESSAEQLANDSQIVNAPPLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIU7</accession>
    <name>A0A084WIU7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018199</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIU7"/>
    <dbReference type="STRING" id="74873.A0A084WIU7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018199-RA">
        <property type="protein sequence ID" value="ASIC018199-PA"/>
        <property type="gene ID" value="ASIC018199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018199"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010323"/>
    <dbReference type="OMA" id="ESEYKPC"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018199-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7376" checksum="30CCC1AF926A3235" modified="2014-10-29" version="1">MGLFDKLANMLKMKKEQINILVVGLNNSGKSTIVNHFKNPNERTSIIVPTVGFSVERFESKYCMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJC8</accession>
    <name>A0A084WJC8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005066-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJC8"/>
    <dbReference type="STRING" id="74873.A0A084WJC8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018590-RA">
        <property type="protein sequence ID" value="ASIC018590-PA"/>
        <property type="gene ID" value="ASIC018590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018590"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019084"/>
    <dbReference type="OMA" id="GIWYSME"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF114">
        <property type="entry name" value="CARBONIC ANHYDRASE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018590-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="28599" checksum="5F30290E8D8A0259" modified="2014-10-29" version="1">MADTSAKNVQSPIALSQRSTAIKDGVQPLDLFGHWDGLGKAKMVNTGSSVMITFSDRPFRPFIVGGVLNNKYVFEQLHFHWGIGDGSGCEHTLEGSTYSMEAHAVHFNAKYGSFAEAVDKPDGLAVLGFFVQAYGDQDCPAFDKIVAGLRHIHTPNAVTDIDADCLKWMGMQDLNRHYYSYKGSLTTPPYFESVTWLVYKTPIYVSSAQLAAFRELRACPKDSSKKIVNNYRPVQVPKYEPEVVFVRNNHPVVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJE0</accession>
    <name>A0A084WJE0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Glutamate-1-semialdehyde aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018603</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJE0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018603-RA">
        <property type="protein sequence ID" value="ASIC018603-PA"/>
        <property type="gene ID" value="ASIC018603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018603"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018603-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7393" checksum="8C749C75F4E34E79" modified="2014-10-29" version="1">MRYDAVEGGEMLLRKSVTGIDYLRAALADLVDAPGWDFRPPGMKLFDGPKDHKWDEVRGLCLVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJI4</accession>
    <name>A0A084WJI4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005212-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJI4"/>
    <dbReference type="STRING" id="74873.A0A084WJI4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018652-RA">
        <property type="protein sequence ID" value="ASIC018652-PA"/>
        <property type="gene ID" value="ASIC018652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018652"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017224"/>
    <dbReference type="OMA" id="ECIESQH"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="267"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018652-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="696" mass="79659" checksum="0C07F4C8D9EF9D48" modified="2014-10-29" version="1">MSNQSAETIGAQDGGNSRVQKITEKFETLITSQKQKQQVVTSPQLDSMHKSPAKRTGFERGDQRFSVPPPRELDARRGIKRSQAFRRSTSQTGTMNGGSAPPSNASNLQLIHSESIREALNKPLPEGPPPEKPPRFVGQEKRTRDTLYGEHDSEHYEDVNMFIQVAFQEPENVLAHESPTREQISLRQPVSEEHRKRIRRLSRCAELNCYTQQYGTIRAYDVVEKRDTGTVDVQDKKTPDTKGLIEHYNKLCTVENAVIPAAQSLYNYCIVVGYDIMQNKPYVKSKYPPQKSLHKMIEVFVYPDNGALIRGSDQEYCIIITDYPQRLYGFCRRVLPESSEFCIPLTYCFVTKHNEPTVFYKLLECIESQHGNGRVPEQLMEQFYNQKLPLAGEKMSLTLPTCLVTHSPLRQKPFAPFTLTISRPKDLRLEKTELYDIFKCLGPDGLIEVFESLLLEKMVILFSEHLSLLASCVQGLLLILYPFQWQHILITIIPDHLQQMLEAPVPMLAGTLQPVPEQVWKSGEACYVNLDKRTVRTTKKEQFSILPSELKKPLRVSLELVKAFEDSKGLASVLIGGAFIRFFVELFSNLDTYSYEKSQFLNRFDNPETKLFLNCFLETVMFADFLENWHASKVLTNGSHSADSFDYSLFNSKITEKSQNKYWHTASFDEIIANSKLIERKGKTFMAKVKNLMKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLN7</accession>
    <name>A0A084WLN7_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Peptidase S10 serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019193</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019193-RA">
        <property type="protein sequence ID" value="ASIC019193-PA"/>
        <property type="gene ID" value="ASIC019193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019193"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="50" mass="5759" checksum="95D5F95201BD6DFD" modified="2014-10-29" version="1">MARDRDDRLISETLRDVRADREMTGSRKCALQPTTLMDPADFKPHDKAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM99</accession>
    <name>A0A084WM99_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019402</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB51343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM99"/>
    <dbReference type="STRING" id="74873.A0A084WM99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019402-RA">
        <property type="protein sequence ID" value="ASIC019402-PA"/>
        <property type="gene ID" value="ASIC019402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019402"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018904"/>
    <dbReference type="OMA" id="PCAGSEM"/>
    <dbReference type="OrthoDB" id="8041741at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
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        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
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            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019402-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="366" mass="39975" checksum="9E34B10F29686C0B" modified="2014-10-29" version="1">MNRGEQENLYRQSRNLRLQQQEAKAHQDQQQQHQQPGGGRPQRHYSYGNIHQYSSASIGLPPDGAMIARGLGSFGLDDHHLQQQQQQHQHQGGMACDDLVLSVLKSPVKETTNLLAGSRSAISASPSAGSNGIAMGSTGTAGTLTQTPSPCAGSEMRNSGGGGGGMMSYRTLQGSEDDLVDDVESAIETTELNASDHHAYKSLHPGSSGPSSSSPRALKFLRRFRPGKPARAFEPHHKRVPTPMRRKNRGRSRSRSTDILDGVGASPGNIVDDDDDDDDVDLDEDAHEIQGVSLGVVGTGEPGVPGGKNLGVPNPYYPIALPIDQAFKAKYVFHHRRGKTVQERFYVFLEHPCGWLCFYYYRFYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-03-27" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNU6</accession>
    <name>A0A084WNU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020050</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNU6"/>
    <dbReference type="STRING" id="74873.A0A084WNU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020050-RA">
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        <property type="gene ID" value="ASIC020050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020050"/>
    <dbReference type="OMA" id="MANIAKT"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="435"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="532" mass="61923" checksum="B56B07F5713E2C3C" modified="2014-10-29" version="1">MIEENEKEIKKAQEKIQELNDIQNAQDTQWNLKATQRDEQIRMALQNLKDAHENKKANEDILRTLETKRVEEEEQRAKKFENALEDIQRAHDEIKNTQKLERDKNVQSAEEELRKAQEIQKVQEAIQSSLVDQSDKAVEQKIQDERQTAKDIQIIETMIETANNNVKKIQKNQESQSIQRSENIKTAMANIAKTQENQIAQDRELKALELQKAQAEKQMSSRIDKVQEAIQKTNEEIKTAQEILKNGNSQAKRKAAETIQEATKNLETQEQSLRNLIKQRNQEQAQFAQKIETVKEELHKSQEQLTAQQVILKNLQDLKTQEEIQSSKDIQNARETIETFEQKIAEARGLLNLRNIQRAEEETVRDLQLSQSRVEIQRAQATQRAQIDILEALEIQEAQQELQRDKDMENAIAQIRKEQEEIKTAQDVARTQETQKAQEEIQKALQLIEAQDEILQSLSNAEVEQAIQRAQETSQSTQDIERAQETIRTAEEAIRNIQEIQNSQNDRRAQVLQTLQQEIQNAQREIQRFEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPG6</accession>
    <name>A0A084WPG6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020427</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025075">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPG6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020427-RA">
        <property type="protein sequence ID" value="ASIC020427-PA"/>
        <property type="gene ID" value="ASIC020427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020427"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020427-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="94" mass="10091" checksum="37D098867FE1D6D5" modified="2014-10-29" version="1">MFLARCAASPPEGEPNVKYVISRSDEMKLSAVSVASVEQEAVVRAPCNRTPKPGETPLQLPVNRQVPANLRGKTLTAAASRDVPFPEALEHKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPU6</accession>
    <name>A0A084WPU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012978-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020353-RA">
        <property type="protein sequence ID" value="ASIC020353-PA"/>
        <property type="gene ID" value="ASIC020353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020353"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020598"/>
    <dbReference type="OrthoDB" id="10554617at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="239" mass="25267" checksum="1EB926813EDFA1D9" modified="2014-10-29" version="1">MYAKRLDYFHYIGYFEANSRGTRDDSSASDEGGDRERDTVTFFLGGCPSTSNLQMSALNTLNTGIITSTTAAAFTGTPTTATATTPTSIGYGSMPAHTNTNNSSSSNLSHLANFSLPAAYTGLPSSSSSLYGGTTPTTPYSPMPSGRDSCVGDSSQSLYTDECQVSSSSSLALTDRIVPPRVKKAPAKLPQTVPSMVGKAPMPPPRKTLSSQRQQKLHDKSSSNNSSKSDINEPFFGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRW3</accession>
    <name>A0A084WRW3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Carbamoyl phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021237</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525408">
        <property type="protein sequence ID" value="KFB52957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021237-RA">
        <property type="protein sequence ID" value="ASIC021237-PA"/>
        <property type="gene ID" value="ASIC021237"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021237"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021237-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6627" checksum="06EAF9AF9480FCD6" modified="2014-10-29" version="1">MTLKRCASLVPVYDSDLGEPLLRNLADGLNVYSLRYGHRGDFSREVIGEAIEGRKEPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU25</accession>
    <name>A0A084WU25_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00022096</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a transcriptional coactivator in Wg signaling.</text>
    </comment>
    <comment type="function">
        <text evidence="1 15">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU25"/>
    <dbReference type="STRING" id="74873.A0A084WU25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022096-RA">
        <property type="protein sequence ID" value="ASIC022096-PA"/>
        <property type="gene ID" value="ASIC022096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022096"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004041"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="65"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB53719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022096-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="471" mass="52499" checksum="E467021BEC39FF81" modified="2014-10-29" version="1">MTDLEKIEIRDVTRIERIGAHSHIRGLGLDDVLEARAVSQGMVGQKEARRAAGIVVQMVREGKIAGRCILLAGEPSTGKTAIAVGMAQALGNETPFTSMSGSEIYSLEMNKTEALSQALRKSIGLRIKEETEIIEGEVVEIQIDRPATGTGQKVGKVTMKTTDMETNYDLGNKIIECFIKEKIQAGDIITIDKASGKVSKLGRSFTRARDYDATGSQTRFVQCPEGELQKRKEVVHTVSLHEIDVINSRTHGFLALFSGDTGEIKQEVRDQINSKVIEWREEGKAEINPGVLFIDECHMLDIECFSFLNRALESDMAPVVVMATNRGITKIRGTQYRSPHGIPIDLLDRMIIIRTVPYTEKEIKEILKIRCEEEDCQISSDALMVLGRIATETSLRYAIQSITTASLVSKRRKAAEITVEDIRKVYSLFLDEKRSSKILKEYQDEYLFYDDSLPKTGSDGQQSQAMEVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUK3</accession>
    <name>A0A084WUK3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022343</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022343-RA">
        <property type="protein sequence ID" value="ASIC022343-PA"/>
        <property type="gene ID" value="ASIC022343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022343"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006272"/>
    <dbReference type="OMA" id="ETSWKHF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026095">
        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022343-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="656" mass="71055" checksum="5B0BB6B929372C6E" modified="2014-10-29" version="1">MPPPRATAIRLRLRNTLLAQRNGQRKKPHHPSQQRQQWQKMWVSTNKVLIGSVGGLKKTHFRNPNFECDETKLLISLWGDPKVQRTLITTHKKHPVIAKLAEKMREYGYNRSTEEINTRIKNLKCFYNRIKKDLEQGTINEPSWKHYKAMDEILTRPVFGGANAAGARKSDEPSTSGGLVTRRSRRHSAGSAGPGDLSEDPDDQIEVKLELVSDDDKDLRPEELLKNAEQVELKEPNLLIPKDEPMEEDADDPNDPDFEHDGGSETDDESSGMDEADESDRSTRLRRRTKRVHKPSKTHPATGGPSTSGNVSKNQPTVITSVATSTAPPVSRAIKIMNYPAGSYLKFTSVASVGSGVSSATNTTGITTLAGGSSAVTTTPSSKISLVPTNFLLKPQASNLGFKQPIQLYTKPTVSIASTTKPTTSLQPVVTVSSASTVSTTGSSTGTPAAPMKLLLVNTLPKDGSAPKQQLINPQTKQIYTTSTGVPLQKVTGLPGSLSIQPRQLVPKPVTGATPIEKLLPTIRPAPSAGGPPKLGGFKALLGQLVGLQRENLGISKTRLLTEKERFGNEKSVANSLMDALGELNALLMEASAELNQSAEEKASEMMHIKISNARHVPSLHALVDQPKEISSRPALQPVIDDESVKTEVISDSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA80</accession>
    <name>A0A084VA80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein KIAA0664-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000529</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01002713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524082">
        <property type="protein sequence ID" value="KFB34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000529-RA">
        <property type="protein sequence ID" value="ASIC000529-PA"/>
        <property type="gene ID" value="ASIC000529"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000529"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000529-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12285" checksum="C039675EF42D8F30" modified="2014-10-29" version="1">MARAKTVIAKVEFNRRAAQTDWPEPAGLLPESRRPGVLLWPPEGGRGDTTSSSCASAPEPETMVGGEEEKCGKKLEAVQKCDRIGTRRGAEELTRFTNGSRAMGRCLGRALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB61</accession>
    <name>A0A084VB61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001211</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524277">
        <property type="protein sequence ID" value="KFB35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001211-RA">
        <property type="protein sequence ID" value="ASIC001211-PA"/>
        <property type="gene ID" value="ASIC001211"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001211"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001211-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="5722" checksum="695025FA0C997426" modified="2014-10-29" version="1">MDPTDAFDNPCDSTGLNVCLSLVTSLWGPNIHVDASEIECKLAAIQVDEEASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCJ4</accession>
    <name>A0A084VCJ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Hydroxymethylbilane synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002583</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524614">
        <property type="protein sequence ID" value="KFB35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCJ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002583-RA">
        <property type="protein sequence ID" value="ASIC002583-PA"/>
        <property type="gene ID" value="ASIC002583"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002583"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002583-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12784" checksum="8A8A51BFCFEEA030" modified="2014-10-29" version="1">MELCGSFRVAASPSLNRKEVTYGLLRRTDTVCLTGIPVDKIGQERNTRNVEDGSTIVARVRFPSSVFRLWAEENLQRKWKLGNGSSPYAINVFAKKTILGGRRMEWFYDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCW3</accession>
    <name>A0A084VCW3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002731</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524624">
        <property type="protein sequence ID" value="KFB35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCW3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002731-RA">
        <property type="protein sequence ID" value="ASIC002731-PA"/>
        <property type="gene ID" value="ASIC002731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002731"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002731-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="8928" checksum="F38E9E831D5085E3" modified="2014-10-29" version="1">MAFVFSSTGGGQSYPPVKSGTLILRSLDQRNEPCLMATLTVPKAQVAGDTGFDIAVQLNPKARTRMTENSAVCENLGKPTEPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCX6</accession>
    <name>A0A084VCX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Exonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002748</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010989">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524630">
        <property type="protein sequence ID" value="KFB35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002748-RA">
        <property type="protein sequence ID" value="ASIC002748-PA"/>
        <property type="gene ID" value="ASIC002748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002748"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010994"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11314" checksum="17E2930479217F61" modified="2014-10-29" version="1">MPTSTKVHQEPTTVVGDDKSYSGEHCRSQSASPARSESPMVASPAGGHVVPAVANFSVINYGKFGDAFRAELATVPVGKLRLGPCSIPGFFYGDRTRAGTGNQSPRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD84</accession>
    <name>A0A084VD84_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006091-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DUF1394 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00002884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD84"/>
    <dbReference type="STRING" id="74873.A0A084VD84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002884-RA">
        <property type="protein sequence ID" value="ASIC002884-PA"/>
        <property type="gene ID" value="ASIC002884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002884"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017374"/>
    <dbReference type="OMA" id="EYRSRFN"/>
    <dbReference type="OrthoDB" id="60973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="324" mass="36805" checksum="735C1C071F128F09" modified="2014-10-29" version="1">MGKLLSLLARDESTCCTPKTYDVFLDFENAAPTDLEREVYEEVDHVLRQSEIVLDEIQCYKGAGKEIREAIADPSPECQEKAWNIVIPLVEKLKRCYEHSLELERIVPKLLGQLVGGRLNPTQHLETQQALVKQLAEILEFVLKFDEYKMKTPAIQNDFSYYRRIASRQRLDAAHEMIISTELANRMSLFYAHATPMLKVLSEATSKFVQDNSDNVDNTTETLGTMAKVCLRMLENPKLLAQIEREETHLLLLRVMVGLVILYDHVHPVGAFARGAHVDVKGCVRLLQAQPAVKAEPLLNALRYTTKHLNEDNTPKNIRNLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VET8</accession>
    <name>A0A084VET8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Ring finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524780">
        <property type="protein sequence ID" value="KFB36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VET8"/>
    <dbReference type="STRING" id="74873.A0A084VET8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003633-RA">
        <property type="protein sequence ID" value="ASIC003633-PA"/>
        <property type="gene ID" value="ASIC003633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003633"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016613"/>
    <dbReference type="OMA" id="MMHEPER"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="127" mass="12917" checksum="AC3CA79119533706" modified="2014-10-29" version="1">MISGGTAGNGGGGDGTGTGTRASFKDSRASLVPTPDAGSVGGRSIATRSLTASPASTSLSCSSSPTLPLAGLMMHEPERVRMRSAAGSNRRRVKDFNDSITCTLCSGYLVEATTVNDCLHTFKSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGM6</accession>
    <name>A0A084VGM6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003764-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004322</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013005">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524833">
        <property type="protein sequence ID" value="KFB37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGM6"/>
    <dbReference type="STRING" id="74873.A0A084VGM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004322-RA">
        <property type="protein sequence ID" value="ASIC004322-PA"/>
        <property type="gene ID" value="ASIC004322"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004322"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006619"/>
    <dbReference type="OMA" id="TTIHYRC"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF12">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="44598" checksum="6A672E206F270A69" modified="2014-10-29" version="1">MDHRVDEALVPAWLDDNFFRTVIRKFTHDEGTELCHGCKLRPGTKPGEHFASVMYRTTIHYRSSKGKEAALDVIMKIKPFQAGLKKDVLNDGDLFVREIRVYSRVLPEMGRRLKEIGETINHPRLIYASEVPHTILILEDVSGKGWQTGQYITSLEEVIPAIKTIAKFHAASVVLQQDNPSFSIEYQCGVVEKLRALDGMLRKSFVDLLAFMRSTDGFEELIVPVEMLQGTLLDGLIQSYAPSTSCMNVLVHGDFHSKNLLHQICSWTTPAVDLFYLLDTIVDQALKERYRDELIYLYHEEFARLLRRLGYLGHITTLLELQMELLQKGALELFHYVALYPFRFIDRSKVDFEQMLSGAAQNPAAGSPVYKRVMRTVLTRFLHQGVMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGS9</accession>
    <name>A0A084VGS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001656-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00004399</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524839">
        <property type="protein sequence ID" value="KFB37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGS9"/>
    <dbReference type="STRING" id="74873.A0A084VGS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004399-RA">
        <property type="protein sequence ID" value="ASIC004399-PA"/>
        <property type="gene ID" value="ASIC004399"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004399"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007663"/>
    <dbReference type="OMA" id="GIHKWIA"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12951">
        <property type="entry name" value="RRP7_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004399-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="255" mass="29407" checksum="63768C1746E1A2B0" modified="2014-10-29" version="1">MSTKEDFTVIPLKYVESDKTGHQLLVKENASKVTCKQKPIGRTLYVLNVPPYATKKSLQQAFSSAGNVERVALQEKPSSKESASIDEMAKNLFKFKVAYIVFEEAASLKKLLKSKKINALNEDGKLLTGVPKWIQAYKRRVPDPVALQQEIDQYMQSYDETMEQKKIEESAKNESEDGWVTISKKNSNAFAQKESVVKRLEKKMDNASSTKELKNFYTFQIREAKKNDIISLRKKYDRDVQKMEQIKKTKRFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHN2</accession>
    <name>A0A084VHN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00004728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524843">
        <property type="protein sequence ID" value="KFB37476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHN2"/>
    <dbReference type="STRING" id="74873.A0A084VHN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004728-RA">
        <property type="protein sequence ID" value="ASIC004728-PA"/>
        <property type="gene ID" value="ASIC004728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004728"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010501"/>
    <dbReference type="OMA" id="MYPAKAG"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB37476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004728-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="185" mass="20345" checksum="1A477A7BBE3F2060" modified="2014-10-29" version="1">MTQASEASKTPPAAGGGAGSAASGRPRITMPPVYVPPPVTGHPQAKYSPAHYFQQLHHQQQQQQQLLLQNPLYVPGSAAIPVTPGSPTRISLGADGTVEAPDYTDYYSMYPAKAGEFMFKQFEGFRDFTVNTAKSGLGVGEKSVFWMYTKITRWSRKWFTHFFLFLMLFLYSVAGAALFIAVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHY2</accession>
    <name>A0A084VHY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004813</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004813-RA">
        <property type="protein sequence ID" value="ASIC004813-PA"/>
        <property type="gene ID" value="ASIC004813"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004813"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004813-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="54" mass="6022" checksum="E76A9E93A8BD8433" modified="2014-10-29" version="1">MGDCEQDDYPRAVRSVSIEGEVLPSSLEFFTIYQIEPRGRKVVFSVNKCAVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VII8</accession>
    <name>A0A084VII8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00005099</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VII8"/>
    <dbReference type="STRING" id="74873.A0A084VII8"/>
    <dbReference type="MEROPS" id="A28.A05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005099-RA">
        <property type="protein sequence ID" value="ASIC005099-PA"/>
        <property type="gene ID" value="ASIC005099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005099"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019463"/>
    <dbReference type="OMA" id="CRMEFNI"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000005">
        <property type="entry name" value="DNA damage inducible 1 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="446"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB37782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="560" mass="60340" checksum="1D024314BD1D0C80" modified="2014-10-29" version="1">MRITVMDANSSDLSTFEVADDMELENLIALCRMEFNIPANMRLVLSAKQQMLVDHKQTLTHYDVKDGDVLLLHKEPIAQPAPPAAPATAAASAARARPMMPPAGTGKRHIEDEFSSATFVPNGERMTLYGRKANEPAALASLDFSSIQVPTSILSSAGAGVQPPGGSAGGSAALPSHLNRPSPSVGLEDDPGVVRDMFLSKPDQLALLKQNNPRLAEALLSGNLETFATVLRKQIAERMEKQQQRLRILASPLDAEAQRLIAEEIKQNNIEANMQAAMEYNPETFGTVVMLYINCKVNGHPVKAFIDSGAQATIMSTAAAERCNIMRLIDTRWAGIAKGVGVQRIIGRVHMVQIQIENDFLTSSCSVLEQPMDMLLGLDMLKRHQCNIDLKNNVLRIGTTGTETPFLAEGDLPECARLTGSPEEEKRALAESAKLAEELAIKEALAKSQTDQASTSGSTSGTSSGNNNTTTTSTSTPASSSNTPPAAQQQPPPATTEQPPPEPMQQDEPMLTLLPTDRFTEMDVVELESMGFKRQMVIDELRAANGDKTKATSGLFSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJD5</accession>
    <name>A0A084VJD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">YALI0E11077p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005352</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013541">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005352-RA">
        <property type="protein sequence ID" value="ASIC005352-PA"/>
        <property type="gene ID" value="ASIC005352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005352"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12235" checksum="CF145DB029B25B11" modified="2014-10-29" version="1">MHLIRDELGGANANARDEPTELVGLFSPSLSRLPKRGLYTHLAVRCKFGQRRTLFHLLAPPHTNTRRFDRSVEWRTQHRPNRTERYVIHSVRYSQESAPLPGFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJK7</accession>
    <name>A0A084VJK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Carbamoyl-phosphate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005445</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013696">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524879">
        <property type="protein sequence ID" value="KFB38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005445-RA">
        <property type="protein sequence ID" value="ASIC005445-PA"/>
        <property type="gene ID" value="ASIC005445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005445"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005445-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10483" checksum="6C915C47EE3FDAC1" modified="2014-10-29" version="1">MPSDEINLAELYLLKTVRPRLLINSLGPVTALSGSREGVGIAPGGDGCPASIPAIAKAESFKRFCCGMTVFGGECLRCAGCRRLWFRQSNSQHVNNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKN3</accession>
    <name>A0A084VKN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005936</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005936-RA">
        <property type="protein sequence ID" value="ASIC005936-PA"/>
        <property type="gene ID" value="ASIC005936"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005936"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005936-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7637" checksum="F99CF9BA971212CB" modified="2014-10-29" version="1">MTTQLRANRTREGEADVCITHEQRKHVEPLSQHAHKGRRHFVQANGKMQPAAGMESFPSENSKPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKP4</accession>
    <name>A0A084VKP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005814</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005814-RA">
        <property type="protein sequence ID" value="ASIC005814-PA"/>
        <property type="gene ID" value="ASIC005814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005814"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="8447" checksum="4C13579B6789A726" modified="2014-10-29" version="1">MDTRCSDVEDATAALYTSAAGDGEHILIVDLPNELISQLPTFPNNHKTRKRRGASFVAMAHIFTGLSSAPGLSCSWLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKP6</accession>
    <name>A0A084VKP6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005816</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005816-RA">
        <property type="protein sequence ID" value="ASIC005816-PA"/>
        <property type="gene ID" value="ASIC005816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005816"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022076"/>
    <dbReference type="OMA" id="LEIDCHT"/>
    <dbReference type="OrthoDB" id="7737235at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005816-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="54350" checksum="92CBFAC4E68B8A51" modified="2014-10-29" version="1">MRMKIIIATDIQNRPIREKLIRAILKTEHHETVFFILDHKLNETRAITYHPYRKKYATPRIDEYHTFYPDYHRNFHNKPVIACSMPAAPYIIANPGSMIASGIDFAMLQVIGKMANIKFLIKIDFVTMAQTAKFLKIFNKTGALIWLNRITLKKTVKSSVTTPDMSEYVIIAPRGQRLTIPETFLRPLTKAAWILVIAMVVVSFLVMWNFNRYFRNDLILLPVCGIERYNLNQTHFAEKLIVLGLMVFYFLLQSGYESIIISLMLDVPYHRDILTFEQLRDGKLPVVVADRHDIHFFMPLFKHYQLPIENGTTLLKVNLQIDKATLHDYRSGKMLIDDVFFYDRINERKRFNLLQDTISAHPTSYVFRHRTRVQETFERHMHTIFEVGLLIHWAQIFQKLKDSRLKVSPPSEDSDLVKFGDLAPFWAVIGVGWSVSIFVFLLERFTTLQLEVKLKAPRSYHHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VME4</accession>
    <name>A0A084VME4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YqaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006468</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VME4"/>
    <dbReference type="STRING" id="74873.A0A084VME4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006468-RA">
        <property type="protein sequence ID" value="ASIC006468-PA"/>
        <property type="gene ID" value="ASIC006468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006468"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012778"/>
    <dbReference type="OMA" id="ESANTFW"/>
    <dbReference type="OrthoDB" id="6774613at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="215"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="403" mass="46007" checksum="836F02C40F905882" modified="2014-10-29" version="1">MSFPFSNIFVVDMFFGRAETNRNRTVFATVLETRRRYGVPYETEHSVEMKFFQKKNKVEAVYCASCAETKARCTVAFTFVDFLELYVPDRKSKKVVPEEATQEKIVTKECYVLVKKENIAPEPASAGPVAPKALTKVEKTPVAPKALTKVKKEPIPITALQLESAQKLSMFSLIKEYEGNNPEDFLKLCTDRMVRENNCSSIELLTIEQADTDLWHELRKGRITASRMHEASRCTMLNGSLTNKIMGLSRGFSFAMKRGTDLEGHVFAVLKKEYPSLRNTGLVLDPQFPWMGASPDGICDEFVLEIKCPYTKKTHDCYVDVAKLSKNYFAQIQLQMHMTHKTKALLAVAALDFETTKNVTKVWIDYDKAYVDKLMAESYEFWCKAVFKALLKKRGTKKRFFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMQ6</accession>
    <name>A0A084VMQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008767-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006599</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMQ6"/>
    <dbReference type="STRING" id="74873.A0A084VMQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006599-RA">
        <property type="protein sequence ID" value="ASIC006599-PA"/>
        <property type="gene ID" value="ASIC006599"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006599"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005868"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021730"/>
    <dbReference type="OMA" id="NIYGIRG"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000026">
        <property type="entry name" value="Big brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF268">
        <property type="entry name" value="NEUROGENIC PROTEIN BIG BRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006599-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="613" mass="66409" checksum="0D56EC2EDFE85BF4" modified="2014-10-29" version="1">MNQSTMSEENHSNIMDKNIDFHIVQLFERLESLRKDPAPKLSLSVQGRANMHKELRTLELWRSVTSECLASFFYVFVVCGAAAGAGVGASVSSLLLATSLASGLIVVVLTQCFLHVSGAHINPAVTMALAVTRKISALRALLYITAQCGGSIAGAAMLYGVTVPGYQGNLQAAVSHSAQLAPWERFGVEFILTFIVVLAYLISTSSFKKYFGSSAIAIGAAYSACSFVSMPYLNPARSLGPSFVLNKWDNHWVYWIGPFVGSIIAGLIHQFVFTPKPKSKGTPKSNNVSGAPPTGVAITEEGCSSYTVDVSKLATTGQGTVQGKFQNLRHHSGTLPSRFCHSMYATTDQPTIKIEPLEPIYGAAKSMFGKSPQMSRSNLNRSQSVYAKSNTALNHPEIPVTVAATATLRPGALVPAQSLYPLRVSQQQHQHQHQHQQQQNQNVQNQLQQRSESIYGLRTTVRQQQQLAEHLSQQLAPRPNLPDGQGFQPIYAIRNNNPSCSNDALRDVHEQAGCDKVLNTHARADRPESMYAATRRIHSTHSDDSSYGSYHGTGQANTPPTREHAGAYGGSLLHPAPNAGRTHTQHSHGGHRGVTILHDPNMPPPPPPLMSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNN2</accession>
    <name>A0A084VNN2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007012</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524988">
        <property type="protein sequence ID" value="KFB39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNN2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007012-RA">
        <property type="protein sequence ID" value="ASIC007012-PA"/>
        <property type="gene ID" value="ASIC007012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007012"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007012-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="190" mass="21275" checksum="EEBCD89544CA1FBA" modified="2014-10-29" version="1">MENFALLVLPLDEEKEEEEAEAKKPEKRYKWHPLYRMPSNRPIDRIVYISRQAPRQFRRITLKECQPTSCPDFAGLTGRIYTHTHTPKDQGERRVAPRSDQSDPQILVTSGAGDVASGRDGPSECAELLPERSSVIIATGLVWGMSTGKTDQKKGGMNCQTMAKVTRTNSSRDHSGTDQHKLSGVNESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNX4</accession>
    <name>A0A084VNX4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013392-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00007118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014940">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524996">
        <property type="protein sequence ID" value="KFB39668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNX4"/>
    <dbReference type="STRING" id="74873.A0A084VNX4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007118-RA">
        <property type="protein sequence ID" value="ASIC007118-PA"/>
        <property type="gene ID" value="ASIC007118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007118"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012404"/>
    <dbReference type="OMA" id="CRRMRYC"/>
    <dbReference type="OrthoDB" id="10067503at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052428">
        <property type="entry name" value="Autophagy_HostDef_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048569">
        <property type="entry name" value="RUBC_PIKBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF1">
        <property type="entry name" value="RUBICON, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21054">
        <property type="entry name" value="RUBC_PIKBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="2">
        <location>
            <begin position="357"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="573" mass="65472" checksum="E0B9361DB063FC19" modified="2014-10-29" version="1">MQNYEYRGRLGRCSSAECLAVTGTVFSKQNSNSAPDLVDHESEVAFVIHRYGSSYHIPQFNYHDCNNPPTSSSTPPTCPTMSPMAPVEYGEYQATPSSIKVRGSIGFLDDFVPQKGRRLRKHCPELDPFEGQCRYWPDSPLERIHPEQGCIPILKAVYFTRNNNDLDKENAHFKLAEALISTFELLKWKSCLNRSSSQLLSNLDWDSANEPSPTSAVSFHDPSTNSDESCEAIEAKETTCDMKTYSAEEIAISLLNKFQDKQLPSAGDFLWLVSEQDAPQKILPMPSGAVIDPDDVHPVYDTSTLIRGTQEWAPPRAQVIFTYKPQPLERREHMKKQGNRCEGCGIKVNKTYMSRYRYCHYTGKFNCSGCHKNQMAIIPARVIHRWDFAALPVSVFAYRVLGDIWSTPLYRVNHLFPGLYSNVKMLRNVRQTRVNMKYVKDFIMNCRHSESLRSIFQEVPEYFTSDFDMWSMADFLAVKNGTLARILASIIARCEKHILSCELCRARGFVCEKCIGQKVVHGKHVLFPWQPKVFKCEQCGTCYHAECWRRDKSCNRCYRMHQRAATGTARNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP24</accession>
    <name>A0A084VP24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Atp binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007409</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007409-RA">
        <property type="protein sequence ID" value="ASIC007409-PA"/>
        <property type="gene ID" value="ASIC007409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007409"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007409-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17624" checksum="18E83C7DDDB9FF23" modified="2014-10-29" version="1">MAPFTGHSGTIPVRFQILFDQINFYVEPEQNPEPEKRKQRTTTSARAGCRCVPALSIMAFRDIYEPERRTVGECDPGSNHSLAPLSPILPLPRTESTRFPGSFQGFQVALRTYGRTDGRAATVWKFKAATLDHQQSYPFSEQLPRLGNSRRLTKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPI5</accession>
    <name>A0A084VPI5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009495-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007255</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPI5"/>
    <dbReference type="STRING" id="74873.A0A084VPI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007255-RA">
        <property type="protein sequence ID" value="ASIC007255-PA"/>
        <property type="gene ID" value="ASIC007255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007255"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018665"/>
    <dbReference type="OMA" id="SQETYVF"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000016">
        <property type="entry name" value="Kelch domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="357" mass="40952" checksum="77E02942F4578AE3" modified="2014-10-29" version="1">MHWILNLDGGPRRVNHASVAVGEFIYSFGGYCTGEDYQSNSAIDVHVLNTHNMRWSPIPAVEDENGVPCKYPEVPFQRYGHTAVAFEQKVYLWGGRNDEIVCDILFCFDTRTRKWTRPSITGTVPGARDGHSACVYGDRMYIFGGFEESIDKFSCDVYFLDLRTMHWTYVNTLGEPPSYRDFHSATIVNDRMYVFGGRSDAVAPYHSQEEIYCPKIKFLDLKTDCWHTPKTTGEIPLGRRSHSAFIYNHKIYIFAGYNGNLDKHFNDLYCFDPSQNIWRLVNPQGQAPRARRRQSCLVIGKRMYLFGGTCPMANADPSSFDYSDTHVLDFEPSLFTLAIIKVLQYKLDTSCLPRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPK0</accession>
    <name>A0A084VPK0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP009483-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00007271</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPK0"/>
    <dbReference type="STRING" id="74873.A0A084VPK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007271-RA">
        <property type="protein sequence ID" value="ASIC007271-PA"/>
        <property type="gene ID" value="ASIC007271"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007271"/>
    <dbReference type="OMA" id="ARAMEYG"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003982">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007271-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7837" checksum="7E3CBAA56182578F" modified="2014-10-29" version="1">MPIKKLLAPAEKPHKCSLCSKSFPTPGDLKSHTYVHNGSWPFKCHICSRGFSKQTNLKNHLFLHTGKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPS6</accession>
    <name>A0A084VPS6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP009439-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00007355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPS6"/>
    <dbReference type="STRING" id="74873.A0A084VPS6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007355-RA">
        <property type="protein sequence ID" value="ASIC007355-PA"/>
        <property type="gene ID" value="ASIC007355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007355"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013291"/>
    <dbReference type="OMA" id="YLQMLPK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB39970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007355-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="391" mass="42823" checksum="DFF480A12F61FC27" modified="2014-10-29" version="1">MIRSSALIGRLPLRGIAAATFNNSAGLLQSSPNFAALQTTQVRHRSTPINTMVMFVPQQEAWVVERMGKFHRILEPGLNILLPIVDRVKYVQSLKEIAIDVPKQSAITSDNVTLSIDGVLYLRILDPYLASYGVEDPEFAITQLAQTTMRSELGKMSLDKVFRERESLNISIVESINKASEAWGISCLRYEIRDIKLPSRVHEAMQMQVEAERRKRAAILESEGVRAADINVAEGKRQSRILASEAQKQEEINRANGEAAAIMALADARAKSLKIVAESLANEHGRSAASLSVAEKYVVAFEKLAKQNNTLIVPSTASDVTSMVAQAMQIYNNLSSATARAATGDHQHRQRRDTDDPTAFGSHSESSIKLDSLQPLESIEGGTAPQTGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQK9</accession>
    <name>A0A084VQK9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.223</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00007730</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16221"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:12574"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:132104"/>
            <dbReference type="EC" id="2.4.1.223"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.223" evidence="19"/>
    <dbReference type="EMBL" id="ATLV01015249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525004">
        <property type="protein sequence ID" value="KFB40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQK9"/>
    <dbReference type="STRING" id="74873.A0A084VQK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007730-RA">
        <property type="protein sequence ID" value="ASIC007730-PA"/>
        <property type="gene ID" value="ASIC007730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007730"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019774"/>
    <dbReference type="OMA" id="KFMGSHT"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001888">
        <property type="term" value="F:glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000033">
        <property type="entry name" value="Exostosin-like glycosyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052376">
        <property type="entry name" value="Oxidative_Scav/Glycosyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39082">
        <property type="entry name" value="PHOSPHOLIPASE C-BETA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39082:SF1">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="22">
        <location>
            <begin position="204"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="23">
        <location>
            <begin position="705"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="962" mass="108619" checksum="65827317906D5953" modified="2014-10-29" version="1">MTSYDTLGGSGGGVLPGIGGLWHWFKHMKLYRVILLVALCFLVGPFVFYHLLQDDESSAPHNDIHRTRSQLDTFEEVSPLKAADLKLRIDEMLRIKGTVSLELRDLESRRQKLQSDIGLYNQKIDELKQELARQQTELDRLKISVEQAQVAQREAVLRNTPELALPRALFSDSLPVERRPIAVEQSRACKMSTCFDHSRCSLTSGFPVYLYDPDTTVVVSEGYDIDGFLKTTIKQTLGYNAHLTTDPKKACVFLVLIGEALPEHEVLKNNRYNTPQDRAATGGAIQQSSLNATRLRMLPYWGGDGRNHVLLNFARREIGTSAGNMLRGTTVDTGRAMVVQSSFEESQFRPGFDLISPPILGPPGGDVWQECVPMLPARRKYLLSFQGELNGQNGSMGGEMGPRLPGTDDTEADTVDEFIIEHLKDMSSGRTQDHFLLQFECVPATEQRNPSNVRDWSLCGTDNSRKSVLKDSTFALLLAPGGGSVSSTLLQARLYEALRAGAIPLILGGDQVQLPYADTIDWRRVVIALPKARITELHFLLRAIPDADLLTMRRQGRLVWERYLSSVQSTVDTIVASLRDRLGMPPKPVPSVVAHSVFNSSFVPLKSDPVIDTEPEESLGPIEPPYPSPAFRRNYTAALMQSREMWNDWADPFALYPQLPFDPVLPSDAKFIGSHMGFRPIGKGAGGAGKEFGESLGGNYPREQFTIVILTYEREQVLMDSLSRLYGLPYLHKVIVVWNSPKPPLEDLRWPDIGVPVHVVRAPRNSLNNRFLPFDAIETEAVLSVDDDAHLRHDEILFGFRVWREHRDRVVGFPGRFHAWDVNTLDSWNYNSNYSCELSMVLTGAAFIHKYYTYLYTYTLPQAIRDKVDEYMNCEDIAMNFLVSHVTRKPPVKVTSRWTFRCPGCPVSLSEDDTHFQERHKCINFFTKVFGYTPLLNTQYRADSILFKTRIPHDKQKCFKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR53</accession>
    <name>A0A084VR53_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ferredoxin-NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007926</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007926-RA">
        <property type="protein sequence ID" value="ASIC007926-PA"/>
        <property type="gene ID" value="ASIC007926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007926"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8400" checksum="94F96493388AF046" modified="2014-10-29" version="1">MGASVLLRYGFFHLYNVRRCCRLVGTGLFLNRPHRIRAESVRSLTMGAFEVEENLPECTRRVERGDLKWGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSI6</accession>
    <name>A0A084VSI6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00008484</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 17"/>
    <dbReference type="EMBL" id="ATLV01016038">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525054">
        <property type="protein sequence ID" value="KFB40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSI6"/>
    <dbReference type="STRING" id="74873.A0A084VSI6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008484-RA">
        <property type="protein sequence ID" value="ASIC008484-PA"/>
        <property type="gene ID" value="ASIC008484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008484"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004271"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="312" mass="34083" checksum="1693B4A805DDD54B" modified="2014-10-29" version="1">MASTKLHSSLFHPTLRKLQCQEDDEAVQNIPSMPGVARYGLNKLLAHLEPLVEKGLQSILLFGVVEKLPKDATGTTADCATNPVIRALPQLKAAFPQLLIACDVCLCPYTDHGHCGVLTSDGIIDNEPSIKRIAEIALAYARAGANIVAPSDMMDNRIAAIKQTLRDNSLENRCSVLSYSVKFASGFYGPFRDAAKSAPAFGDRKCYQLPPGSKGIAKRAAKRDVEEGADMLMVKPGMAYLDIVKQVKDDYPELPLFIYQVSGEYSMLLNAASIGAFDLKTVLWEVLVGMRRAGADCIITYFTPVLLDWLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT42</accession>
    <name>A0A084VT42_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP002890-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00008702</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525060">
        <property type="protein sequence ID" value="KFB41136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT42"/>
    <dbReference type="STRING" id="74873.A0A084VT42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008702-RA">
        <property type="protein sequence ID" value="ASIC008702-PA"/>
        <property type="gene ID" value="ASIC008702"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008702"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023630"/>
    <dbReference type="OMA" id="GQCNPKT"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008702-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="419" mass="47679" checksum="C85F59251567302B" modified="2014-10-29" version="1">MVVIRSTVFLLSVKFIVSVHRQLKRQHSGLPQMESLSRFSSIPMVETGLKTAGTVYKRVKTSNGLLTWGFETAESITYALLDSLRPATKMIEGPLHQLDSIMCKSLDLVEQKVPSMYLPPEMMFWNTKEYMNDHLMKPVLTRANSMKNLGHAVLESRVSNRVADRIDGALVVCDKYVERYLPTEPQDQPDSPTCTPAQPDDSNEMHVVQTFHRGQQFSRKLKRRLTFRTRQELSALKKQSTEAVHVVAYAAELIATNPRLAMQKAIELWRYLSKDEPENQARPQTLEQVAVLLTRESARKMVHLINFVTTGVTRVPNAVRAQTRELMHHFLFATERLMKTVHLEKAKNATLSEASGLVHRIQHTYDDLQNQTNLALERLAVFLSGRLEAEKITTSGNPRRRIQPRPNSNPMNSNINGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUG3</accession>
    <name>A0A084VUG3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009228</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01016788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525113">
        <property type="protein sequence ID" value="KFB41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUG3"/>
    <dbReference type="STRING" id="74873.A0A084VUG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009228-RA">
        <property type="protein sequence ID" value="ASIC009228-PA"/>
        <property type="gene ID" value="ASIC009228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009228"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004562"/>
    <dbReference type="OMA" id="GHTLYPN"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000208">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="25103" checksum="666CCFC95A54C30D" modified="2014-10-29" version="1">MPTPTLYYFPMSPPARAVLLLVKELGLTVNLKEVNPLTGETRTEEFMRINPEHTIPTLDDNGFYLGESRAILTYLVDAYRPGHSLYPNIPKEKALINRVLHHDLGAFYPKFFGSFGGLFSGAQTEITEENRATAQKALSDLENYLVRNDFFAGENPTLADLTLLPTIATAVHCGLDLTKYKRLNEWYENCRQLKGFEEDQEAARQVGEFLRSKFPEGLQALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUN8</accession>
    <name>A0A084VUN8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Putative mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009310</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUN8"/>
    <dbReference type="STRING" id="74873.A0A084VUN8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009310-RA">
        <property type="protein sequence ID" value="ASIC009310-PA"/>
        <property type="gene ID" value="ASIC009310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009310"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001475"/>
    <dbReference type="OMA" id="FLMRCAP"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759902" evidence="7">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009310-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="254" mass="28144" checksum="0E524445E9879A9B" modified="2014-10-29" version="1">MVHQLIGITILLAISIAAARSQQIETSSMCEGKEINSFVPDPDNCSKFFQCNGDTFIHGSCPTGMFYHPQDVCSFDDTNCSSSTEQTTTSSSSSTTEESNVTSSTVIPEPSSTTAAPTDPEQWCADVDPNRPHFIKSPTQCSEYYICVNGKAILQKCQEGKYWSAKHFYCDDPKNVPCAFDRIPNPEQFCNTSAEDEISFTASPTDCGEYYICVKRLPFLMRCAPGSHWNDDIKQCDDPRIAGCKVRRKSDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUU6</accession>
    <name>A0A084VUU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001008-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009373</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525142">
        <property type="protein sequence ID" value="KFB41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUU6"/>
    <dbReference type="STRING" id="74873.A0A084VUU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009373-RA">
        <property type="protein sequence ID" value="ASIC009373-PA"/>
        <property type="gene ID" value="ASIC009373"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009373"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020504"/>
    <dbReference type="OMA" id="IEIAWEY"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009373-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="407" mass="46325" checksum="8920448B851131D9" modified="2014-10-29" version="1">MVSSSKLLFNRASLGRTCRDLWHPQFASCLAYNVHFWRTILPGSFKLYIPFLVLPPLVKLNDVDWRYLWDHTLQYAYISFCTYVQAALSLSAQCGLFHLVGRLNYWCVMFWPCLLGVAIGPPLPNQLLRLQAITFFNMSLEAAVRKSTSPVVRFAHRSNTLATVSFMAFSSIILTCLRSGLVKQFWLVNPDPVVRGSVRCEHPGCCRRHLLDGMLKYGAVGLVLEAGRAVLRQSTLLLRNPLAIFGGKFLRSCNLRLGLFLACYVGIFRAVCCLLARRRGHEQQALMHTALAGFLAGVPYCIYPTYQIYTLGVTKAIEIAWEYCLTVHTGPTIDEEPKSLRTTVLRHLQRLPMLRLVQMCSFGYLGHVYAFYPRVSPVFHQKAMDVCSTDLTLNMKLRLNRWMKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUX2</accession>
    <name>A0A084VUX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525145">
        <property type="protein sequence ID" value="KFB41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009408-RA">
        <property type="protein sequence ID" value="ASIC009408-PA"/>
        <property type="gene ID" value="ASIC009408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009408"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009408-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13218" checksum="FF7944D24564EBB5" modified="2014-10-29" version="1">MATQWHLRDYQLNLRTTSQPSNRPTDQPTNRAPFDNFLPSHFPLHGPVRCAVSGTCHTGAEPISHRNTGPNGSGIRQQLCAAYFQALRFISISLALTGSRDGLSVETLPRTPGHHGRDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV83</accession>
    <name>A0A084VV83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009722-RA">
        <property type="protein sequence ID" value="ASIC009722-PA"/>
        <property type="gene ID" value="ASIC009722"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009722"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009722-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11009" checksum="AEA33FE1A0D23479" modified="2014-10-29" version="1">MYFATSVGVGRLDASFTEFSEDGRRRSWAQFNCVLPGHECGSVVRSPQPSNNLLLLMGAQLVHPSFRRARELQLTELGLGPAPPSTVTVRGGVGEEGRALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVV6</accession>
    <name>A0A084VVV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00009760</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVV6"/>
    <dbReference type="STRING" id="74873.A0A084VVV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009760-RA">
        <property type="protein sequence ID" value="ASIC009760-PA"/>
        <property type="gene ID" value="ASIC009760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009760"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004266"/>
    <dbReference type="OMA" id="AYYLHHY"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF83">
        <property type="entry name" value="COMPLEMENT FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="35"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="286" mass="30680" checksum="2C390271FA41D6AE" modified="2014-10-29" version="1">MRVEKIEPKATMFERFGHFLLLVAVLSLPTIIEAIVRSESDSWARSAWFPFAVSLQLIDRGFEHFCGGTHLGDGWILTAAHCVIAFNHSQIVAQIGGQNLNDTTIVRYPIVEMHIQGTYNRVTMVGDIALLRVAATGSGSNAFRLRPRSNVAKRLSLPAPSDGTVVNGEQCYIFGYGSESYEGPVSPTLRYGTVLAFGIDSCIGMMGAVVAPPPDSGMFCAIGQADACKGDSGGGYVCRKPPSNQFVLRGIISYGVGCGAAGTPGVYTDVAYYLHHYSMSSLMSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVX5</accession>
    <name>A0A084VVX5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP003349-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009792</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525163">
        <property type="protein sequence ID" value="KFB42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC009792-PA"/>
        <property type="gene ID" value="ASIC009792"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS004405"/>
    <dbReference type="OMA" id="RHSKFAK"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclic nucleotide gated channel beta 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclic nucleotide-gated olfactory channel"/>
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        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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    <dbReference type="PANTHER" id="PTHR45638">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
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        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="746"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="175"/>
            <end position="198"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="225"/>
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        <location>
            <begin position="874"/>
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            <begin position="1085"/>
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            <begin position="1772"/>
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        <location>
            <begin position="1939"/>
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        <location>
            <begin position="20"/>
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        <location>
            <begin position="37"/>
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            <begin position="1994"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50042"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    <sequence length="2016" mass="221630" checksum="868D7B3E5ACA4CBF" modified="2014-10-29" version="1">MDPPNPSAAGTASGGAILPTCSTISSASSQMHPYGAASGGHGATGSGSGGGGVGADHGANLLSPTLLSPGTNTGTASIATSRDEEDDSSNQASSGSKGSGQRVRRGSSAFRTPPEVRTSLVSRAGSGEGGGQRGRTYQSTEPCRSTSSRYQSIDRSHSFTDQDSDAMSRWYQYHQQRHPLSRTGSRTGSGQRRRYSLRDDIELEDGSLNRMVSLSDSVGGGHGSCGGLLTRHRVSHPSVTSSSLDPFEPNQLHPPSNQQQQHQQQQQLSHSVSNGTSRGAQSWKNLRAVMAYYCSLRKIKRNVQLLRSTTNICDEYLHEIRNTYINNQSNFNCNTHNLLKSMKITDISTKSNQRWMKLRTTVQISSAMQKKPPLKREDSFLKRFSTRQIPEAQETVEDTGSEGATDAEKSVRRRRRFAKIPRTVVNPDENFYFYWLMIVTISILYNLWTLIVRQSFPELQSNASRFWLSCDCLTDIVFIFDVAVQLRTGYLEQGLMVYDSKKLAGHYLRSRAFLLDLAALVPLDILQFRLGSQPMLRFPRFFKVYRAVKYYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGDWVYPYRPGDYATLTRKYLGSLYWSTLTLTTIGDLPTPETNAEYVFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLTAMKDYPEAQEILQTLGRKRLMEVRCVNKKHASKHAAKEHAGDRSSNTHNNQGDSSDNSASKRIVDKLRSDVKGLKNVLRKSRTGTTRRSNESIEMQPLQGNAGGGGGGGGGGGGGSGGSGGSGGSKTPKTMLKRMARVKSDDIHTEDEGKDTDKVPSPIGAGLPLLQRLRMLKEKQDREERAAKATAQIISPPHTHVTSAISPQESIQEEPEPEVIGAGLPLMQRLKLLKAKEDRLAKESQSKLQVTSNQTSSSPSIVQSMSPTSPTVKAPPSPILNTAGTATHHHLKPTMRVSFKDRIRSLHHQDSKHHGEAKLPSLPGTIHETTDMKQHLLQQSAALQGKVAHQAQSQPQQQHHAKPSTQKTQTFKDRIRSLGHLQRDDQLKPWSKLKLATVVSLGGSYTSLNNASASEESPILKQSKRSRIKTSIPADLNLNSLVSLTPPPISSAPPTTCAPQTAFLPNKVLSCAAGEKASVSDSEVASGSGTQRTMPGGTIAVQGRASLGGAGSGTAPARVRMKPKPIKLDSAPKSYMSIDDLSPEYCGLPFVKKLKILNERQKLAELESAIKTRSLSLDCTDSNTSTGSTHDPLDQLTRSQSEGSGMANSVRSKSESPRRSDSNGLLPLSPESNETLERRQLKSILKKLSEDKAALEQRPTRDLKKLMRAQTVEGYVARHSKFTKSVTFHRNTLSSPPSSANQCDSIEERSLFPLLSAQTVAGAGSGSGGAAGVGAGIALSPVAAVSTSDDSVSVATTIEQQHERYYQVLHEEHHHLHHREEHHQFHRVSPPGPPAGVDVPAVGEDGTRHALAVISNGDAHRGFPYDPHADGGMDLEPDATGQETRTSLSALASQRKLIKGSLEEQEFFGEVLLGIKQVIQTHMKEIQVKFQDEFFNLELEVKKRDDIISKLQNRILELEAEQHQGLMVQLPPEQGGDVPYHQSGSSGSGSTGSSNELPFMRGDSLDTIFASSPHSDSDAPRQPKVRSRKPRTSPRHRQLRNRPTWDESTDQESFDRKDSPPLGHRQQQSGYVTQAGGGPSGPPPPVPPRRMSTTTTSTTTAVTLSTTDRIRSPYRDLVISELTGNIISDSVILNIEPTSSSQSESQSENDDDRRSLQRRSLLDEDDEEEEEEREGDEARRLVRRRHSRSRETEDDDDDDDDCDDEQDIGEAGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW15</accession>
    <name>A0A084VW15_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009824</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017373">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW15"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009824-RA">
        <property type="protein sequence ID" value="ASIC009824-PA"/>
        <property type="gene ID" value="ASIC009824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009824"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11609" checksum="61C1C720E96F172A" modified="2014-10-29" version="1">MEWTIVRDRPRFISRPHSLPGFSVYVWTNQPPPQLVISHNPRVHFVPVPRDARASDHYGKLPATNDGHKHTGSSSAPDVVGYIHRRVKGGRVCGRELMMDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX37</accession>
    <name>A0A084VX37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Peptidoglycan recognition protein 1 short class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00010240</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525195">
        <property type="protein sequence ID" value="KFB42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX37"/>
    <dbReference type="STRING" id="74873.A0A084VX37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010240-RA">
        <property type="protein sequence ID" value="ASIC010240-PA"/>
        <property type="gene ID" value="ASIC010240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010240"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017513"/>
    <dbReference type="OMA" id="RFVVIHH"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF74">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="49"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010240-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="177" mass="19683" checksum="9603FA980CECA9DC" modified="2014-10-29" version="1">MAQEALPESACMASVVKRSAWGAAKSTNVTYQLKPVPSVIVHHTTGDRCTTAAGCRELVRNIQTYHQTQNGWSDIGYNFLIGNNVVYEGIGWHRQGAHLRGHNDKSIGVAFIGNYDLERPTPRTLQLLNTLLQCGVELGELSAEYRLYGALQLQSTNSPGKFLYAKLKEHDHWSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXS7</accession>
    <name>A0A084VXS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010517</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018205">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010517-RA">
        <property type="protein sequence ID" value="ASIC010517-PA"/>
        <property type="gene ID" value="ASIC010517"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010517"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010517-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11102" checksum="E93B177A098DD365" modified="2014-10-29" version="1">MVKESGSACCRISWIVSEWAISNGRSTGWEGQSIEQAAKRIGDRNRRSTSFGRMTVEINRRNSMKSDDPRIGPIFTGKQGASLGCNFCRQRFQENGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY45</accession>
    <name>A0A084VY45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010645</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018276">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010645-RA">
        <property type="protein sequence ID" value="ASIC010645-PA"/>
        <property type="gene ID" value="ASIC010645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010645"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010645-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="19617" checksum="A89769E8A223C8FA" modified="2014-10-29" version="1">MRQVFSTVEFFAVLHFAPSPRLVAWWSASVAGLGFLEVQGLPFKSNLHRASRNDSCTTLTGTTSAALVMSMLIFHRVLVFGVCHRVKFKLGVRPPIDDKDDDDYDKRVDKQVPEAPVTCESLAIRRVQARRSQKHALLIIAELNQRAITDVFQRPERANFVELAFFHLSQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY54</accession>
    <name>A0A084VY54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006444-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00010659</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018304">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525228">
        <property type="protein sequence ID" value="KFB42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY54"/>
    <dbReference type="STRING" id="74873.A0A084VY54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010659-RA">
        <property type="protein sequence ID" value="ASIC010659-PA"/>
        <property type="gene ID" value="ASIC010659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010659"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001278"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002799"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015565"/>
    <dbReference type="OMA" id="LEHENFC"/>
    <dbReference type="OrthoDB" id="10037824at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000065">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF4">
        <property type="entry name" value="GH12701P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="397"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="818" mass="90952" checksum="760B3E14EC470267" modified="2014-10-29" version="1">MKPRSDEPRRTACHFRQQPVSHRSHRWQHRRGWLHTVPPVPGTVLLATLTLATLVAVAAKSGSPSTVVTSSVGNAKTSFNQPKDTVSVIALAATSQKQASPYHSNRGTAQRSQCALSEHTCTNGRCIPWDKYCNNVNDCGDGSDEPRFCTRCNRTYYGDIGLTYNLELHRPKEDRIPYVCILTFTAAGGNFGDIVQVTLDSFTLGRFTSYTENGCPDGYLQVSEAKRANVGGMWCGTTWGPAIFYSETDSLVMTIKLFKLSRDQSGYNFDFRIQYKMLSRASAVVRYGGLRHEYIPPWTNEVAGGGGAGQRNRMVFSAFGSNHDLMQHYPATTYDNMTRGGHTPGTSSYGYDDRPGQTFGRLNASMMDWTAGVASRTQLNYTEPQYYLGDLMTGTFCSRIFTNCDKKVCRLQSPNFPGIYPRNLTCYFAVRQHDVPPGKHAFIVISQPKGNLVWISTEASAGAAPNAASRDEKEKYKPRLQTWNECDSVQDYITVYDGYTTRDPIILKICGGGQAIPQAISSGPELLVEFTTSPYGTFNTPQTSGHSLHGFQLEVSVRFVDLQTPTYAKSKRICEFWLRGTGHGVLQNPLHSLAPNTTCLYHLQGTEARALDAINIPRRSGALSTSPTRFKVWISVMKFELAPEFGATEEQLLQYQTKEDCSGMLRIWDGPLREVPICKDIDCLTTEKDGTQRSSIRFGANTTNIIARYCRGSVPRSCDHGILNVSSSRPCTLSESFVSSSDFVTLELKTSDSTVLRPLQFALRYEFVDLLQDGTAIGSEHECNRRFASSQMERKGPHQVRSVRNIFLFGRGGAKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYZ8</accession>
    <name>A0A084VYZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018576">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525238">
        <property type="protein sequence ID" value="KFB43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010969-RA">
        <property type="protein sequence ID" value="ASIC010969-PA"/>
        <property type="gene ID" value="ASIC010969"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010969"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010969-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="246" mass="27515" checksum="4C372DA70891E72D" modified="2014-10-29" version="1">MSDATLPNRCVFGAVSDEFTLSVVFHQPLGQTRPRSSRFRKLEAHRDGIIMMESCASMRLKLKDGKSAGQKCIPLRRSDGGRVKGKRTRARKSENPTNPATHQHHLISELFSWKRPRMIHFVSMKVEHILHRVDRGRRTGGVGKRASRQLFPTVDFSVAPSSRERGGGVGPEYIARPRHKLISFPLYPIRSPPILPPSASGATAARIIRFDGGFHPVDLATRLDPWAASGTVEELLKPKYRRLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0A3</accession>
    <name>A0A084W0A3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carboxylesterase</fullName>
            <ecNumber evidence="5">3.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00011591</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01019107">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0A3"/>
    <dbReference type="STRING" id="74873.A0A084W0A3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011591-RA">
        <property type="protein sequence ID" value="ASIC011591-PA"/>
        <property type="gene ID" value="ASIC011591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011591"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006757"/>
    <dbReference type="OMA" id="ENSCHEM"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106435">
        <property type="term" value="F:carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784314" description="carboxylesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="22322" checksum="DD05FC08D47E9950" modified="2014-10-29" version="1">MTFLKFVVLVATLTSTQINGRTSDKLKVTLPHGGKVIGRYLHSFSGRGILAFLGIPYAKPPIGELRFKASVPYGAWVGERMAITDAPLCTQRDPYRRDEAISGVEDCLQLNIYVPERPNSSSPDKLVATPFPVMVFFHGGGWQCGSGTRSFYGPDFLLEHDVIYIAANFRLGPLGFLSTEQADCPGTMGLRIKVWFCAGSRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0C6</accession>
    <name>A0A084W0C6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013230-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011397</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0C6"/>
    <dbReference type="STRING" id="74873.A0A084W0C6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011397-RA">
        <property type="protein sequence ID" value="ASIC011397-PA"/>
        <property type="gene ID" value="ASIC011397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011397"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015679"/>
    <dbReference type="OMA" id="WYPPYPM"/>
    <dbReference type="OrthoDB" id="7669009at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011397-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="446" mass="49431" checksum="9FE7882018F8D83E" modified="2014-10-29" version="1">MTEELQTQQQPQPATVQPQPKQRLGPQDYRNSELVTKLMAANPPYLYSPAVGPHNFFFSEMLRSLVANKRNESLRNASEQLHHHQQHHQQQQQLQQAAQHPGQVPNHLALQAATTRRPRKRSWSQHRYYPEALKEGKESEERRPTQPEKPLELTNKLSAFSRSISSSAAASSTQKYPENDLPERFKAPSYHDRKPEESKTSLGADKASMNNANLIPEPSTASMPPSDLILPPPPPVWYPPLYPPYGIDPLHFFIDLRVSGHIYDRKKDSNSPGSEESSLSVKREHSKLIGTGADRQGSAFSVPKPRDSSTGSKPSGTGSAINLAASLEEGGGSSGEVVEASDQPSPAMGSLFLGDFADHKMDSIKNTNYVLQNLPRIYGDLNGNHKMVDRCAGDDDMNGNLSDEHEQDQDSKSVESVEDLVGDENKYKDIDLNVISDEESIAVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0Q6</accession>
    <name>A0A084W0Q6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Methoprene-tolerant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Met</name>
        <name evidence="5" type="ORF">ZHAS_00011641</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2023-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Xing X."/>
                <person name="Si F."/>
                <person name="Chen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="OR783325">
        <property type="protein sequence ID" value="WPC83335.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0Q6"/>
    <dbReference type="STRING" id="74873.A0A084W0Q6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011641-RA">
        <property type="protein sequence ID" value="ASIC011641-PA"/>
        <property type="gene ID" value="ASIC011641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011641"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008031"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013948"/>
    <dbReference type="OMA" id="QMYDYNQ"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11391">
        <property type="entry name" value="bHLH_PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WPC83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011641-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114460" checksum="82AA4EDEEB38384D" modified="2014-10-29" version="1">MSTQGYAPGSDGMSRRSSYYGHRFYGGPSSGSSFDDAGPSTGHGMRLNNPSSADDNGFAERFEGFGPYAEENRPFFPPTLHPASGSYQPSLGYSPHQHPHHHHHHHPGAGRYGYTPSGALRMQQDVGMYGGNYSPSVPTWYQHPSAHQHHHPHPHGGYQQHLAPHQPHHQSATPRCYPLPPEHMYSMFNFNRNGREARNRAEKNRRDKLNGSIQELSAMVPHVAESPRRVDKTAVLRFSAHGLRVDYVFGKSKPEETFKPEAQDSLFRMLNGFLLTVTCRGQIVLVSPSVEQFLGHCQTDLYGQNLFNLTHPDDHALLKQQLVPTNLVNLFDGAASPGSGPVGTSSSTSGSSLAMLSPPLEGKPGDEQEPGSDQRHSQHDEEEEIDRRLRKDTRKFTIRMARAGPRSEATTYELVTIDGCFRRADLAPRGTAKSGGGGTSGMQMIRRARGRDEAIPLHSINGNDIVLIGLARVMKVPSICDRLIEACKYEYKTRHLIDGRIVQCDQRISIVAGYLTDEVSGLSPFTFMHRDDVRWVIVALRQMYDYNQNGESCYRLMSRTGDFIYLKTRGYLEVDSDTKVVQSFVCINTLVSEEEGQRLVREMKRKFSVIVDKVELPDESGEPVVENPMQIEEAVMNLITNLDGEEKLLSTMPASPASSVKSCGHGDGMPGLAIVAPEKSSIKSAIVKSINVVSIASKTIREARSSPGDWSPLNGDQQSSNDSSSTGAPPQRATVLQKRGESASPQPSGSGSSVEQRVPPLPNSEHYFTQPFSPSGGGGTSVLSPASSQHSQRNVRSPHGYGGSVPSPPSNAFSRAETTSGGQTRTTSVLKRTYSNSSICSLTSSDNYTEYNSLNGGNPGESKRCKTGSPDLASCFNELMNPASDLTSFLPNSFDVVDQSLTLMETTTTIIREQVSNFPNLHESHNQLERIAEEHQEQRQMLQSIQEEFQIQMSNGVGSRSAAGRQGPRSGSGGNDNRTGLVTVTTPSTTPSTTSYLLAGSVVDSDAIFCNTGPHGRQSGGSSSTVSSMMPSVITPNIGRTQAHGSTLDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W110</accession>
    <name>A0A084W110_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011727</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W110"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011727-RA">
        <property type="protein sequence ID" value="ASIC011727-PA"/>
        <property type="gene ID" value="ASIC011727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011727"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012816"/>
    <dbReference type="OMA" id="YPQVIQE"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000098">
        <property type="entry name" value="HEAT repeat-containing protein 5A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000138">
        <property type="entry name" value="Putative HEAT repeat-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2043"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2116"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2120"/>
            <end position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB43904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011727-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2150" mass="234747" checksum="10187611D0B6D134" modified="2014-10-29" version="1">MGHNNDNLSLFRYIRDAATSSLKHFPQLQSSEANPCDGYNEEEEEAEQTARMELSHSLTLNEAALAQLPEQKRPVFIFEWLRFLDKVLVAAQKSDIKGCQKKLVEQLTQHIQGAPGPPTRKLIARCLATLFSVGDTFLLFETVNKCNDILKNKDDSPSYLPTRLAATCVVGCMYEKLGRMMGRSYEETVQILLKSLKNAESQSRIEIMMTLEKVCAGMGSAISNVHKDIYKAVRYCLTDRVMAVRVAASNCLLEMTKHAPFLYTTELESLASLCFRAFDSCNYEVRCAVAKLLGTLIACTQNGSLRNFSSMTASSSSTKSLRPVSLDEALGVLMAGFLRGGVSFLKGTGEIIKGSSGVNREVRVGVTHAYVVFVQTMGGLWLERNMQSFLVHVLDLVANPKAASSHVDAVYSRKCINFILRSVIGKMLGEKAQSSACKELIHLIAKQMNSIDFNPENAKDSNQETLFSQHLLVCALQELGSLVLLLGTTAQNLLADQQLNFIDAVCAVLIHPCMAARLAAAWCLRCVCVAVPSQITPLIDRFIEAIEKMRTSPDAISGYSGALAAVLGGVRYSPLGIPHTRGKVIFNTAEELLRTASQNSRLSLNRTQAGWLLIGGIMTLGVPVVKGLLPRMLLLWRNAFPRSTKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLHCPELVTDDITRRLLTPIESALAMLINITSVLKTYGQHLKAPTAMVRLRLYETLSLLPATALESSYTHLLRMLVSEFTLTENPANTTTSFLRQMCHGNDSIILGTWLQDTDHRTIEDQLQPNSAAGSGALEHDACCLYRAIAPGEQCPGPLPLGVAVIDMSVTLFGLIFPKVANKHRLQMLEHFGECIKHAKSSRQEAVQMNIFTALLSGLKGLTETKSAIGQDDVRKSATNLIINALTSANPILRCAAGEALGRIAQVVGDSRVTAELAQTSFDRLKSARDVVTRTGHSLALGCLHRYVGGMGSSQHLNTSVSILLALAQDGSSPVVQVWSLYALSLIADSGGPMFRGYVEPTLSLALKLLLTVPQSHVDVHQCIGRVLSALITTIGPELQGDSNSVATARSSFLCAAAIMQAHSDPLVQAEATGCLQQLHLFAPRNVNLSSLVPNLCQNLSSNYLTLRKAAVSCLRQLTTREAKEVCEHAANLVSDEDRYALSDYGLPGVLFGMLDTESDSQMVRNIHDTITSMLQILAAENLSQWLSMCKNVLTVASDASVGADGGTSNTTGSGAAADHQATHPAVQPRWPTRVFAAECVRKVIATCENASSNHFDLVAAKEMQMTKSRGDFLVLHLSDLIRMAFMAATSDSDQLRLEGLKTLQEIIDKFAHVPEPEFPGHLLLEQFQAQVGAALRPAFSQDTPSHVTAAACEVCSAWIGSGVARDLNDLRRVHQLLVSNLSKLNSRTNSTQLYNESMATLEKLSILKAWGQVYIMAMVGHGAAPASQMLKTLHTVSGGQSLSSTAQPKEFNRLAFDEEFGDFESRGESLLSLVQPELDNLSKHWLAALKDYALLSLPAEYASQLPHDGGAFYTNDTMNLSKPHYLISWPPILYAAALWLNAEGFVKGEHRLSQEQEEDKANANDVGSLAPPGSRGGGQSGSTPTVPTISHGSLSADRFHLIFGICMEALCSTRTNEKLDSVIACLQALYTIFDSHWSREMLMQNKTLPVELCNVLHRLILTRDSVEVQYLCISILKQTIAAANECLEREKNDERRKLVVANGPSSGGGEEGEILPGKSLVYAVLEVVLCLLARQIPNMNPSQSTRVANEQLQRQLARAQHGLIKLGDDNSLLVANAIQSLNDLTKLCSPLGALSILPTILYLTTGVIKEVATKSVHDESLTAGTNVVQVAVQLLRTLATDRYGKHEQSGDEWRKLLQSALGRIIDLTKTGCEETKMDEVTVMLAIAVFLLHSPSAVVSVPNLQYPCINHFRQCFQSASLPVRLKCVQTMRSIFANADLKVSTPYIHALAPRLIEHLYSEQARNPTNEQELALVVEGVTTVETLIALAEPQNRIQMLTLLVPILINYLDDPDKQQQPQQRGGGSLSAKPTTKYTNALNDHAIQWLMKIGPKYPQEFKTLMAQAPELRRKLEAAIKRSQLNASLQKSKSEAANAAARNSAAQQQKPTIQLKTDFSNFNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1P8</accession>
    <name>A0A084W1P8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019401">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525269">
        <property type="protein sequence ID" value="KFB44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1P8"/>
    <dbReference type="STRING" id="74873.A0A084W1P8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011979-RA">
        <property type="protein sequence ID" value="ASIC011979-PA"/>
        <property type="gene ID" value="ASIC011979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011979"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020912"/>
    <dbReference type="OMA" id="THEQMSP"/>
    <dbReference type="OrthoDB" id="8194914at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="499" mass="55551" checksum="9303D8FC0DD08694" modified="2014-10-29" version="1">MPTTTSTTITTSDSKRVECKTRSGTKATFSKLLNSPAQTQSLQTPRYTTVETSTPRRDESYTYSKTYKTVTESSSSDPYSRPSTSSSSYTSTSERNSRGGPGGYSYSTERTSTTGGGPGGYSYSSTTSGRLPHGTTYRHYSYRFNTITTTTTTTYRTPMPYVAHKRLVPVTRVVSSPPRVLVSPLRVLGSPVRVVHSPVRVYGTPVRTVRAVRSPARVIVSPARIVTIRSPYLRPSIINKEFDRIERKYRASPVSSALEQYYNSPSYLEFEDEKRDIRNSTALLLRQLNDPVPRMLAPVAQAAPEPNPKKWVYDPFSTHNRLNSDTYVKSHITDPIRSVRNDIEAMARYHSPASRYVGKNHLASTRIIGSQAYPKTKPRIYNYDTAKVGKDVNVMSYYKSNRTQAKADVEEGKRDRVQRKQDKQSKARSKARADARKQQTPSPPPPTPPPSTLPQPSSPTPTSSPLTETCPVVDSNGVPTFTTHEQMSPDRLSPEPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1W9</accession>
    <name>A0A084W1W9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Transposase, IS605 OrfB family, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012103</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019471">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1W9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012103-RA">
        <property type="protein sequence ID" value="ASIC012103-PA"/>
        <property type="gene ID" value="ASIC012103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012103"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023024"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012103-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="8751" checksum="2BFCE7FA2B86840F" modified="2014-10-29" version="1">MCMEPRVAITAIAPGYSARLPATTGTIGTGGANLDACERSCQGPSGNEYGQPSSVSGAKEASVGSVIDDRMPSVKTSDLNAFFSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2D4</accession>
    <name>A0A084W2D4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Bursicon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB44378.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10122" checksum="1931868784AEF0A7" modified="2014-10-29" version="1">MKSTLLVVLELAFILLPGRVLHAQKDNASGSGLSHPNHTQQADHVSTKAPLECMCRPCTGIEDANVIPQELTAFADEGTLTGYFQKSHYKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name type="scientific">Anopheles sinensis</name>
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    </organism>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC012262-PA"/>
        <property type="gene ID" value="ASIC012262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012262"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001496"/>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB44473.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012262-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="720" mass="78742" checksum="6DB8582B7BC66899" modified="2014-10-29" version="1">MVTISAHSMRSLALLQFIWCCCVIFPPTAGLENLLTSFEIRHGYVYPTSVTVAEGEVMHLRLLVPMQNGDRCLYREPGSSVDIDVHASTDGARNVAHRTRRNVNGEPELLRILENECGIRVNPVHRGDAGFWRLTLVRGTDRIRGVSMVDVIERPSVPEVGVGGGASVSSLDEISPERTEYCYVLRQGGASERQVQHEVPMHERCKLPLSSTDPTGAGVWNVIAGVQGQMRELTYGIQIENKDEQIITTTHREADYHVLSCHLRYTQLMLKFCRFVRLSDGFGLNVIPGIGTSRYGYVGDGFERNECGLEILEPDGLGQGASGNEQIITTTHREADYHVLSCHLRYTQLMLKFCRFVRLSDGFGLNVIPGIGTSRYGYVGDGFERNECGLEFSNRTVSTGASGSVCSAXXXXXXXDETVTAQNESTVSLQCNANKPIDYCWFRGPHGQFYSLSEGLSEERGAGHYWYSGISLAMGECGIGLGTINDHEHAGRWHCYVGNGHVSALEVSAGFNVRVSPSQMIASADTVDSVLDFPALLGCDSIPRGTPLQYCRFVTPTGEAFSLNENVTSDRPVLERFYSNPNHNLARGSCSLVIASVRQEDFGQWVCAGKIDGHATEHIAQLVLHNRDEVPEPSEEPAPASETLSAASITGMAIGGVAVVGGAVGLGYWQYRKRLRRQVSAVNAEIQMRDVSRARISVVSSDSGSSTNSNIDRPVMQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W351</accession>
    <name>A0A084W351_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00012532</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W351"/>
    <dbReference type="STRING" id="74873.A0A084W351"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012532-RA">
        <property type="protein sequence ID" value="ASIC012532-PA"/>
        <property type="gene ID" value="ASIC012532"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012532"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007646"/>
    <dbReference type="OMA" id="MERENNQ"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00240">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
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        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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        </location>
    </feature>
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            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012532-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="564" mass="63420" checksum="18C1F8B5857AA2C1" modified="2014-10-29" version="1">MSAPSNSKSTAGPSQPAPSGTSSAPVSVQEFVIRVPKNLKKKYHVMRFNATLNVDFTQWRSVKMERENNQKEFKGMEEVMPKFGAGSEFNRDLREEARRKRFGIISKKYKPEAQPWILRAGGKSGKMFRGIREGGVGENAAFYVFTHAPDGAIEAYPLNEWYNFQPINRYKALSAEEAEQEYGRRKKTMNFFSLMFRKRLRKGEDNDGEEQEETKGKKEGGKSKDLKISDMDEWIDSDDVSSSGDDDEEAMTRRKIRKAKNKKKALADSKKKKRDVDEEAFEESDDGDEEGRELDYISDSSDSESDHDAKVVKEMKSVAEEDALRKLLTSDEDSEEEEKKSDEEEEKEEDKNGKSKEKDKDGKEKESKEAKKKKKAKKNKNKKSESDKKDSSSDFSSDSSDSDAASSKKKMKSKKEKEGVGSNLSSANNSRSASPSVSQFDSNKRKLVGSNMPSTDLTGSDNSNSPVSTPAKKMKSDSAPSIPPTFAGIVNTSSKDDNGITEEAVRRYLMRKPMTTTELLTKFKNKKTGVSSEKLVETMTQLLKRINPVKQTIQGKMYLSIKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3F1</accession>
    <name>A0A084W3F1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00012644</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="ATLV01019962">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3F1"/>
    <dbReference type="STRING" id="74873.A0A084W3F1"/>
    <dbReference type="MEROPS" id="M49.A01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012644-RA">
        <property type="protein sequence ID" value="ASIC012644-PA"/>
        <property type="gene ID" value="ASIC012644"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012644"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000165"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000008">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012644-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="705" mass="79867" checksum="094E4451885B403A" modified="2014-10-29" version="1">MSDKAQYVLPNTQPIVELECATAFNNLTEKEKQYAHFFSKASWTGGLVALVQSSPESPLIFSLLHRIFLAEPVDTLKESAISAGVSEDEFTAFLVYTCGFLANAGNYKGMGDSKIVPNLDENKFELIVKSSAAYKANNELIGSLWERTKVPIFLLTERTKTLGLCDTGVTTYFSSNVTREDTELISEWMKEHKFEAYICRTFKTEENGKTVYDIKLASSEEGDKKGLTREPEEYKGCIFKITRGDYKELMQLVADALEEAKNFRQGSLDAHKTGSRYWIKDKGPVIETYIGFIETYRDPVGQRGEFEGFVAMVNKEMSAKFGTLVSNAESFIKLLPWGEDYEKDSYLKPDFTSLDILTFAGSGVPCGINIPNYDEIRQDEGFKNVSLGNVLANTNKTDAIPFLTEEDQALMKKYKAAAFEVQVGLHELLGHGSGKLLRINEAGEYNFDLKKLTNPLTGEPVDCWYEPGETYDSKFKSLGSSYEECRAEAVGLYLCLNRDVLKIFGHTDEQEIENIIYVNWLLLVWGGVGVAMELYNPTQKAWLQAHYQARFVIMKVLLEAGEGLVNVQETEEGKNLLLKFDRSKIETVGKEAIRKFLLKLQFYKSTGNVKAATDMYNHYSEVSEGGSHPWAKWRDIVLLHKKPRLIFLQANTEVESDSGNVKLKTYEANFSGYIQSWVERFTDVKVDEVLERIYEADKHYYEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W403</accession>
    <name>A0A084W403_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00012860</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="EMBL" id="ATLV01020246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525296">
        <property type="protein sequence ID" value="KFB44947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W403"/>
    <dbReference type="STRING" id="74873.A0A084W403"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012860-RA">
        <property type="protein sequence ID" value="ASIC012860-PA"/>
        <property type="gene ID" value="ASIC012860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012860"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000659"/>
    <dbReference type="OMA" id="QEWAFSK"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000065">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000026">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="373"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB44947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012860-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="501" mass="57198" checksum="AE859ACB9BCF9C57" modified="2014-10-29" version="1">MTWDYFDETSYIQKGGLQRGEDPYLRNRFNQQASDGLKSNRELPDTRNAMCRRSSWSEPSSIAHLPATSVIITFHNEARSTLLRTVVSVLNRSPERLIHEIILVDDYSDFPEDGQELAKIQKVRLIRNSKREGLVRSRVTGAAAATAKVLTFLDSHCECNVNWLEPLLARVAEDPTRVVCPVIDVISMDTFQYIGASADLRGGFDWNLVFKWEYLSNAERKARQRDPTAPIRTPMIAGGLFVIDKAYFQRLGTYDTQMDIWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGGSGNIFAKNTRRAAEVWMDEFKKYYYAAVPLATNIPFGDIDDRLQLRRELQCKPFRWYLENVYPQLSVPDRRNNGSIRQGAYCLDSLGNVAGAVVGLYSCHGNGGNQNWVLNRKGELKHHDLCLTLVKFTISAKYNSVLMKYCDDSENQQWRLKDGGLIQHRKINVCLDSRHMKERGITAERCNSALDTQHWKVVTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W581</accession>
    <name>A0A084W581_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013213</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W581"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013213-RA">
        <property type="protein sequence ID" value="ASIC013213-PA"/>
        <property type="gene ID" value="ASIC013213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013213"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013213-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="123" mass="13138" checksum="E71E0C6204D08774" modified="2014-10-29" version="1">MSEREGKIGSSDRWLMLSRSRSQGWTAQERGTERNQAVAKNVSLFGLQPRATRAGQKPGRGTCLHAKRQMRSTAERVTKSTPKVAEGPAIFLCQPSGSPGTIAEIVINISTAGSPTNIGNGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5P6</accession>
    <name>A0A084W5P6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial glutamate carrier 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glutamate/H(+) symporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 25 member 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00013488</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020679">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5P6"/>
    <dbReference type="STRING" id="74873.A0A084W5P6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013488-RA">
        <property type="protein sequence ID" value="ASIC013488-PA"/>
        <property type="gene ID" value="ASIC013488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013488"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018748"/>
    <dbReference type="OMA" id="NEAVFWC"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000026">
        <property type="entry name" value="Putative mitochondrial glutamate carrier 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="28083" checksum="7E97ECA40AE81E35" modified="2014-10-29" version="1">MYNSMLDCFKKTYRAEGYFGMYRGSAVNILLITPEKAIKLAANDFFRHHLTTANGSLPITRQMAAGGLAGLCQIVITTPMELLKIQMQDAGRVAAQAKAAGKTLPKVSATSIAMELVRTKGITGLYKGTGATALRDVSFSIVYFPLFATLNALGPRRDDGSNEAVFWCSFLSGCAAGSMAALAVNPFDVVKTRLQALKKAEGEMQFNGVADCIGKTLKHEGVTAFFKGGLCRMIVIAPLFGIAQMVYFLGVAEALLGTKSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6M4</accession>
    <name>A0A084W6M4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013853</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC013853-RA">
        <property type="protein sequence ID" value="ASIC013853-PA"/>
        <property type="gene ID" value="ASIC013853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013853"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="73" mass="8401" checksum="B89F1B3E4B950FF1" modified="2014-10-29" version="1">MVEDNGDLRRHGGSNCRHCDRRRRHLWYSLRESTEACARLLVVLLSEHLADEGTIXXXXXXXGQQFVLPSTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6V8</accession>
    <name>A0A084W6V8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP004318-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013935</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6V8"/>
    <dbReference type="STRING" id="74873.A0A084W6V8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013935-RA">
        <property type="protein sequence ID" value="ASIC013935-PA"/>
        <property type="gene ID" value="ASIC013935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013935"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013777"/>
    <dbReference type="OMA" id="VDIKWGC"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="130"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013935-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="377" mass="41451" checksum="20F864B9BF7B5169" modified="2014-10-29" version="1">MDISISRTFSNNNHRRKALRQGESCTHQGEQGVCTPFSKCVRGARITVCSYSAQEAIVCCPQSQLIRADNVPQTGPFESTNRDLGTRKSVQMCNEYKKLTTERVAISSLTLNPTLVNIDVPKCDTVVKLIVGGNVTKPGEFPHMAAIGWPKPTGGYAFECGGSLISDYYVLTAAHCYLESDDGALPSIVRLGDQNLERSDDGAEPKDYDILRFILHPQFRRSVGKYNDLALIQLQTRVTFTNFIRPACLYDSDIINARTAIATGFGLLEGFGIKSDDLRKVALNIYDNALCAEQYITNRFVRQGIKNTQLCVGDLAGGKDTCQGDSGGPLQITHDENQCIFYIIGVTSFGKVCGSSTPAIYTRVTPYLSWIESVVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W704</accession>
    <name>A0A084W704_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Flap endonuclease GEN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease GEN</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xpg-like endonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00013966</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB45998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W704"/>
    <dbReference type="STRING" id="74873.A0A084W704"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013966-RA">
        <property type="protein sequence ID" value="ASIC013966-PA"/>
        <property type="gene ID" value="ASIC013966"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013966"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022369"/>
    <dbReference type="OMA" id="RNLYFRT"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09905">
        <property type="entry name" value="H3TH_GEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09869">
        <property type="entry name" value="PIN_GEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000054">
        <property type="entry name" value="Flap endonuclease GEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041012">
        <property type="entry name" value="GEN_chromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF70">
        <property type="entry name" value="FLAP ENDONUCLEASE GEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18704">
        <property type="entry name" value="Chromo_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="18">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KFB45998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013966-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="741" mass="84760" checksum="CDA9385DD7B146C1" modified="2014-10-29" version="1">MGVKDLWNLLTPYMERKPLFELSNKVVAIDLSGWVCESLNVVDYFVHPRFYLRNLFFRTCYLLQTGITPVFVLEGTAPPLKYGVIVKRNQIQFRGARPKKIANCDKASSTTTATKEKTEKPKEQKRNRFHHVLKQCEELLSAMGLVCVQAPGEAEALCAYLNHDNLIYGVISQDSDCFAYGAVRVFRNFCASQNGGSVEIYDLQRLDNSPLRLGQEKIVAMALLSGCDYCPAGVVGVGREMVTRFLSCYENNAILPRIRSWRSTANRLTELEIRAEDKNICSDCGHVGKLLQHRKSGCMDCRMKPGCAETRWKQQRANVKAELDIKRKALMDPAFPHEPIIEEFLTRPCELPKLDLSWRQPNLVKFIKSMSSCMQWNELYCFQKILPLFTRWQMSAAKFTPEKQLNIFLQPDFIKKKRNPKGIASYEIVWNDAQNMFHGLIPQEQIDAYLEEAGNSLECLWSTIEPQELVLQAYPELVDAFLQRTTKGKKKKPLSQNNDQEKPKKKRETQATGKEKKRAYKKKDVQHPSVKDLLNKAASQQKQEKTPSQDTENVAQTFSSMEIPEDVDHFLNFTAELEAIADDCTVNESFNSSVLIDRLCHPNYLQRALEEYTAIIESEKKTAALQDLLSQSITVMDTVESATEENGVQRRLVLKQDILNASLNNSLLNHSIVRPRKAKRMSFFFEPIDIPPPDDQQQYHETDAMDMFECSLMLKDQIVIAPSPCDEISDPNQTIIYDIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W799</accession>
    <name>A0A084W799_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP002841-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W799"/>
    <dbReference type="STRING" id="74873.A0A084W799"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014070-RA">
        <property type="protein sequence ID" value="ASIC014070-PA"/>
        <property type="gene ID" value="ASIC014070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014070"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014256"/>
    <dbReference type="OMA" id="ENMGLTH"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="250" mass="28551" checksum="37A56C6569BB5F19" modified="2014-10-29" version="1">MFSSNGRILKRLVVLDFDHTVCEHNTDIVVRDLLGPEGIPPDVRSILRSGGWIPYMQRVFRLLHQGGFGPMDIASAIRGIPEVPGMKACIANLVRRGFHVIIISDSNSEFIRLWNDFNDIGRYIHTVFTNPAQFDSNGLLELRPYHHQTECTLSSKNLCKGKILEQFLRRQHDERNVEYEKVFYAGDGKNDVCPMLRLSSNGFACARRGYACYDALQSAIGKLEHKYTAKVLQWTDGYELSDLIWTELEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7Q1</accession>
    <name>A0A084W7Q1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Gambicin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014133</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </citation>
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</entry>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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</entry>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
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        </source>
    </evidence>
    <sequence length="1379" mass="150287" checksum="6B79B555A00DF39A" modified="2014-10-29" version="1">MAVAYFVYADYASSGRSLQFLEDYINKEVLPAFGDISCISAVTGLQSHLYDNEARDLVRAAVGANAEDEIVFCDNPTERLCYLLSNPNVCDLSQPHTLQGLSAPPILFVSTSEPVSNLRSWIDAGWQIERIVKNHEGFLDLVDLEKRLQHYSEGRRKMVGLFSGASRLTGILADDVATTILLHQYDALSIWDHSMAASCAPICTNPVLPGAQKDAIFFHCNRLVGGVQAPGVLVIKRRFIEHSTSFLTDSVGVVSAVRAGLVLQLKESLGSQAIMGRMEKTCKQMLAHVRTIPEIVLLGPPCTTAKRLTTLCFMVRHPRGAFLHHRFVVAVLNDVFGIQATADNMISDSLGINPQLSVEYEKLLNDESLQSGCLHPGYTRITFPFFMPEAEVAFILEALKMVATEAWKLLPQYEMDERSGEWRHHSNSLAKERKWLGAIRYIDGKMLFSDRRISGPGSFPQNYSDCLQTARNLFNRARKMAQRSTTEQIVLKLTNAAMEKLRWYMLSGEAHELLLGHSHNVKNTVPFDPTRIPENSSLMLIHRHHSLSALDIKRFKSRSLPASPLQISTRRQNSSSPSPYQSHSPTPTSSPPMVRFSVGGEVTTMLNPTPLANVGVGSGPGPVGSNVVTAGAPSIRRDMNVSRNRCHSWGAASYRTAIGGLSSREGTPSDADNDGPVGANGGGGAGGNNLHALSPQTRASLGLEPHQHPLRAAYHTQLSSPGPSQHQRPPLHRPYSVAAVPSATPSGSAGTPGLRPKQRSCSCSSQTDLSLPRNESPPQTKRTAASPTPSLPNLRSLMGSSCSESTEDIQAYVKEVTKELATEIKSEIREVISKVEDVLESTDSIELNSLVNFNSLGQHSHPAPIENKRDSISTSDVVDYLREFSREMTNEVKSEIRDVVNAVDEIISPEGGGFLGARKNSPPDILRSNAANGGSGTTTGGHKLLVKQRYSDITPGAATHRPRSADNNDSKHRSESFPRPSSAASPEHIVGLGPPLHYTHAANAVAGAILKSADLRSTMSSQDSGINMSFCDATDEHSRLRTVRAPASDRIRTVSAEIDSSNKPSLPPRRLISEPTGGSIIEAASPITTDDASQTDPSGGGKGGLTRQQHVLNRSPSGEATGPAIAEGPIQWHQMPQEVWKQAAETLDEYRMLKDGDRVLVCISGSSSSLCLLHLLHQFCRTRQLQVQLAAITIGGSDGGVDPRALMLYLKELGVTFFYEPLASNDQLQDQLLQHARHRQYNVLAMASTLDKLADRFLTSLLYRGELTALQAVQGACGAKDTTTDDVRIVRPLLYLREHLFDEFALSQGFPSRSSSRGHDACPNGTQVSPIVELLRGQEKVNPHVYNNIRSALKPILSLRIEPSKSAYEMLRSSLNTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W948</accession>
    <name>A0A084W948_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014746</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021603">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W948"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014746-RA">
        <property type="protein sequence ID" value="ASIC014746-PA"/>
        <property type="gene ID" value="ASIC014746"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014746"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014746-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17683" checksum="89F26355C7066F17" modified="2014-10-29" version="1">MEEEKNSGDVLTIHLEWYGQKLEFWEKLAGRIVCASRARIVAGAQNTHPTKLTPTPGVLDGKCYMCNEIAFLSPYYYVVANKLIEMSHVTSIQQPAAPVPPHPPFHPALDSRFRYASGRETWDAELEQSVKGMNKPSHHRPINAAPMSRRKIPFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA06</accession>
    <name>A0A084WA06_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Exonuclease 1</fullName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00015119</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="EMBL" id="ATLV01021992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA06"/>
    <dbReference type="STRING" id="74873.A0A084WA06"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015119-RA">
        <property type="protein sequence ID" value="ASIC015119-PA"/>
        <property type="gene ID" value="ASIC015119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015119"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008498"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022811"/>
    <dbReference type="OMA" id="ATFKHMV"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 17" id="KW-0228">DNA excision</keyword>
    <keyword evidence="15 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 17" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="625"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="749"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015119-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="842" mass="93629" checksum="C5B7C6C0C6B92E34" modified="2014-10-29" version="1">MGITGLLPFLEKASSTYHLRDLRGKCVAIDSYCWLHRGAFGCAERLARGESTDLHIQYCLKYVQLLLSYNIKPILVFDGRHLPAKAATESKRRESRENARKRGAELLRLGRIEEARSYLRRCVDITHDMALQLIQECRRRNVDCIVAPYEADAQLAFLNRADIAQYIITEDSDLVLFGCNRILFKLDLTGNCRMVDASKLHLAMGCREERFQFAKFRYMCILSGCDYLDSLPGIGLAKACRFVLKTEDPDIRRALAKIPSYLNMRQLSVSEEYKDEFLKADATFKHMVVYDPVHRRQTRLLDPDEEGTPEAYCCNAGEFLDENTALNLALGNLDPFSLRQMDDWHPDATDDADGAVPNTGKRRHPSIWKKNYHALVEEKQLVRQIPSKHKTASMTTFVKRPPPNAHFEEQGTKDTICDVLQAYGIQSNEPPLKRLCYTQTARSSTLSSVAIEYEDVNALETMALLEQQPTTPKRNRNPFVVAATSGGSVASRDSPNADLLSPTKITPENRSLLQNISPVKRIDYSQQRQGSVAAATTTTSRLSRFTRANTTATNNGGQKVISRFFCTQQTKVQIASTLHSTTKAKSPEPNKTGTDSSGALYESPTAIVKAIKSKRSQMLEATALYLQSPEAQRMDRGERTPEKGTNPHLASPDDGRSQLGRFDSGIAMGEKDQAEDDNPLEEPNSSDGLSSSQKENDGTGMFEAATECTSPRVKGSVRLALFERQQGKKVGEVNRIENDPEEALAIVIDDDNDDVDAVGIGRKQESKQRNASPPTRKLPEPETMKPTAVGAKNVKSRASCRRPGLSATRKQSSKGDNGGGLTQSRLSMFGFQKKPSMQLGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA31</accession>
    <name>A0A084WA31_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00015118</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA31"/>
    <dbReference type="STRING" id="74873.A0A084WA31"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015118-RA">
        <property type="protein sequence ID" value="ASIC015118-PA"/>
        <property type="gene ID" value="ASIC015118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015118"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018091"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="18697" checksum="DEB625A17F12A341" modified="2014-10-29" version="1">MQPSAYSIGTNVKLLIDRSDGTYCFRENKSRVYYMPEKILKLAETIPKDNLVSVGTCFGKFTKGNKFILHITALVYLAPYAPYKLWLKPSAEQQFLYGNHVAKSGLGRITENTPVYQGVIVMSMSDVPLGFGVTAKSTNDCKVADPLVTVCFHQADIGEYIRSEDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBH2</accession>
    <name>A0A084WBH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00015531</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBH2"/>
    <dbReference type="STRING" id="74873.A0A084WBH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015531-RA">
        <property type="protein sequence ID" value="ASIC015531-PA"/>
        <property type="gene ID" value="ASIC015531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015531"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012093"/>
    <dbReference type="OMA" id="NGYECHA"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB47566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="34265" checksum="11DC2982DB4D1988" modified="2014-10-29" version="1">MAQAKDIMVHEPFTTVAVKKMKSHDPEKLEAMLSEIKIIIRIGQHVNIVNFLGVVTENIRNNELMIIFEYCRYGCVHSFMQKNKSKFIDCMDDLPMAWKPTTIDRNLNEEESNGGMRKSFRTTDLIYWATQIAGGMGYLSSKNVFHGDLAARNVLLCENNVVKIADFGLTREFNRVTHYKKTRKDRVPYKWMALESIFEHIFSMKTDVWSYGVFLWELFTLGSPPYPTFVVNEEFFNKLKDGYRLERPQYACEDIYYMMLSCWCVNPERRPTFVELESFFNLMLPPELQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC50</accession>
    <name>A0A084WC50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015868</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015868-RA">
        <property type="protein sequence ID" value="ASIC015868-PA"/>
        <property type="gene ID" value="ASIC015868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015868"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8513" checksum="ACD84B504C0741CC" modified="2014-10-29" version="1">MYLLSALQVEREIEPKDQQWRNSSIGGRKGSIKIAHLNDAKHNGSILLTAPAPCAVKDDPLEVAGDGILRSFGKLMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCW6</accession>
    <name>A0A084WCW6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016030</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022891">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016030-RA">
        <property type="protein sequence ID" value="ASIC016030-PA"/>
        <property type="gene ID" value="ASIC016030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016030"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13636" checksum="774959BCCF433865" modified="2014-10-29" version="1">MQQEVGQNAVAQLWPRPLGRAVVGPLYVEGKKWDHRDVFARPGPAKELAPWRWQNAAQAHAREQDKQNVMCFHLGEPASYGQHRPVHYSTSAHAKDRLVPATVRQHIRLPTFASASNANEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCY1</accession>
    <name>A0A084WCY1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016046</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016046-RA">
        <property type="protein sequence ID" value="ASIC016046-PA"/>
        <property type="gene ID" value="ASIC016046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016046"/>
    <dbReference type="OrthoDB" id="10622651at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784629" evidence="2">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB48075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="250" mass="27682" checksum="1D9E565F87212A9C" modified="2014-10-29" version="1">MAKITCIIILGLVALGSGKPYESDHRSSGALRQLRYELHRFYDSDRVTESEFLYRLFDHLPEDRNAGEEKHRDSDTDDLSLDGEQFEDESGELNDTADIVHPRNRVPDQQELKVEHDKPKPENQKQDPSGGATADNVKRKDKNGPPKDHPTGKAQPDAKSEGNVDSASVPSPGSDKTLDETQGNEHQPRGKPLRDPHPKDSESKKEQKHEDPSQVEKSPSPSSSNPPQSEAQRKPEAPLVQINVNVAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD40</accession>
    <name>A0A084WD40_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016197</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016197-RA">
        <property type="protein sequence ID" value="ASIC016197-PA"/>
        <property type="gene ID" value="ASIC016197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016197"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13253" checksum="C99981DD144D05FA" modified="2014-10-29" version="1">MSHRLGQAQQACGVRGSRMRPHSKVSHRPGNAARNTKTHDCALNRRGVWSGRPLGAKLKVIWRRNKARLPRVGVILAGRNFRPSQSVNRCGGRCLFEGGDDWYVAASSRKTHTPSMTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDE8</accession>
    <name>A0A084WDE8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Spore coat protein S, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016364</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016364-RA">
        <property type="protein sequence ID" value="ASIC016364-PA"/>
        <property type="gene ID" value="ASIC016364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016364"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10188" checksum="156449760D9803E0" modified="2014-10-29" version="1">MRCAMDSSYFEISLRPGSGSLFGRKKADPSHLASKGQNGKLSQNPHRIRPGFLSPSCTYDSRLAEALGFTENHSTKIDRKTFRRMLPMVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDR4</accession>
    <name>A0A084WDR4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP012444-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TsaA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016477</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDR4"/>
    <dbReference type="STRING" id="74873.A0A084WDR4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016477-RA">
        <property type="protein sequence ID" value="ASIC016477-PA"/>
        <property type="gene ID" value="ASIC016477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016477"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022425"/>
    <dbReference type="OrthoDB" id="4882at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016477-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="187" mass="20683" checksum="2E0EA20E91276FB1" modified="2014-10-29" version="1">MTPACRIDISSTVFNNPSHSLEGLESFSHIWIIYHFHRNPNHLKAKVAPPRLGGERVGVFSTRSPHRPCPIGLSLVQLDRVEDSKVYFFGTDMVDGTPVLDIKPYIPQYDVPVNMSEIEFYNSREAPDGEETSLMDNNPPGSSSQSVSSVSVPNWVLNSSILDVVFNTNAESQLQALGIEKVKLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDT7</accession>
    <name>A0A084WDT7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Exonuclease rnase t and DNA polymerase iii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016503</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023063">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDT7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016503-RA">
        <property type="protein sequence ID" value="ASIC016503-PA"/>
        <property type="gene ID" value="ASIC016503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016503"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7025" checksum="73933EA6240EC21B" modified="2014-10-29" version="1">MTTAKNGSASSILSNLRPDLDTRSLPRTTMTTRGPMVVDQKPIGKHRGRRIAIESQVKHRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WER7</accession>
    <name>A0A084WER7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00016713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WER7"/>
    <dbReference type="STRING" id="74873.A0A084WER7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016713-RA">
        <property type="protein sequence ID" value="ASIC016713-PA"/>
        <property type="gene ID" value="ASIC016713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016713"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017099"/>
    <dbReference type="OMA" id="TIMECVS"/>
    <dbReference type="OrthoDB" id="9976048at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA methyltransferase 10C, mitochondrial RNase P subunit"/>
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        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="304"/>
        </location>
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        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="339" mass="40565" checksum="8C45E0E91EFBF4CC" modified="2014-10-29" version="1">MEKRRKILELEIEVMRQEGRKVPSLSSIKPDQWEHLLTLASRNQRRHYYMYLWNIEVVRQSQKIKKERKQEEIAKRREELMKATAENDHIVYGLFHNTMFLRIYDSTVDHFHNNRLIQAMQFGINLVIDCSYDEYMNDKEMRNTAKQLMLCFAQNRAHPEPFNIHHCNADYSKTTMKQLEKHLVQIHQPEFPFNITERSYLDLFPKERLVYLTPHCKNDLTEFNPDDIYIIGAMVDKSSQEAVSLGKAKKLGLRMARLPLDNYFQFKSGKSLTLDQMVMIMLELKGSNDFGKALQFVPRRKIITMDEETEREKQRQEANKFKFNFKRSGDKWNSSKKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG90</accession>
    <name>A0A084WG90_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Protein HIRA-like isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00017240</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <begin position="72"/>
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            <begin position="78"/>
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        </location>
    </feature>
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            <dbReference type="EMBL" id="KFB49234.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="165" mass="17649" checksum="052E9902B3480384" modified="2014-10-29" version="1">MSHVAIAVGNQCSSILESAFDRNTTTVSYANIINRGETSCGGGDPNYEVSVQLVETFDRFADANQFDMRLQGGKGGKLTNNAHRSHRSITATPSKAVASSPRAAVCGYLSPTVAPSERPEQLFCGCKCWCTTADDCFPRSENRAPPFGSRCETVLATIRTHPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A084WG99_ANOSI</name>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="gene ID" value="ASIC017440"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KFB49243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017440-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="202" mass="22902" checksum="5C2F2DECBBBA79E1" modified="2014-10-29" version="1">MRRALIRFRLSVSVSDLLSHPSVADGRCRPADVPLRFTGFWGLRKGRPYMCGVKIVRRFAVVINRRDVDNFGGCWVRCPEEERNVCATDKDVPFCPIILCRRSVCRLVDVSCTGKLDRHRGTQIKKKAAGATRECSVQCANGVDSLQYVAHAKRFKASWCGLKIVLHHVTGFFESLHEQGPWGHYRDFTLGERNTRPGKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGH7</accession>
    <name>A0A084WGH7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006598-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023571">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGH7"/>
    <dbReference type="STRING" id="74873.A0A084WGH7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017438-RA">
        <property type="protein sequence ID" value="ASIC017438-PA"/>
        <property type="gene ID" value="ASIC017438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017438"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010232"/>
    <dbReference type="OMA" id="SRFTHMQ"/>
    <dbReference type="OrthoDB" id="10020110at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019391">
        <property type="entry name" value="Storkhead-box_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040126">
        <property type="entry name" value="STOX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437:SF0">
        <property type="entry name" value="FI21431P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437">
        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10264">
        <property type="entry name" value="WHD_Storkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix Storkhead-box1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017438-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1051" mass="113333" checksum="9C8A1E21737CA9B1" modified="2014-10-29" version="1">MSTNSPGTPKKCRLILQQCLAIQLTKPGNPPEDFWMYDSGYTIFQNFLSANLQCWWNAPLAAATKVLKYLGHISPGMLLITAEPCALEIIRSAYARSVLKPPATYLINSVGDIDDCIVTPIVQTQFTPLTEALCDVIMELTSQGQSATIENIRNRLRSRFTHMQQPSVEVIYDTLVQLMQEIKIYQTSKGYFIETTQQNKHLGVRWVPGGVDLDSQAPTKESKTLLMSSHEALSSLYGEISTERAGDQTHQCIQTNLADVICGGNPNDKILYPRSVSKQRSSSFPSNGGKTLERRHSLRFFGSSKRLQRSASTRSLSKNYAQTIAKDGTTTVPAGGTPGAPPSPESPPSALDAKKQTSSQSLLSRIFRRSTRSKSKTKQIETYSAQFPPPEWFNSKTTHLHSVGTQTTDYLDFPIKSRLLNSTFYDSSDVSQRSLSLPRRRHHRRNLSSESTFFISSRDCSPVRRGKSPASYYCGSLPRSIHSTPASSGYYKVSRGKQLSSADKLHSSSDSQATSAVASSAKLDHNKTTTTTSRQHPGSGPSSIDSGKMTYVTSGPSSFDSEKLSSTRTSTHSSLESHVSSSTITTAIQQQQQNQSNNQSSGSSGQSNSSSMFFTNDTNGKSGSSSTNASPSRGSLNGTRPVSSVGTPPTPGTVTTVMTAVASTTKANNSAYKCFETTFGYSRTNTDGTKPPRPAATSPLGAGVGLHITKPIDHLTALSESLLQFRLNGEAQTQGGSSPTGSSTATTTPATIHTIPIQQHGSLDNGCGQLPELNKYNKNSTMNNSKVMQGTGANPVQPAANFFYKNVLKNIQHDSKNICGDLAVEKTTPRCYDDLPGSGVGGGRNGLRRSNSEIKKLNSQHQPTLGKQPCPGDDLTIGGGAKCGQALPQPQLSGLIVMKKSLSVSSEPNLLANGDKNNAQITILVKENEGEPLGNGDKPKGGPHAQTDFDELDRRYSYQARDEPTVLEEMYAFPSLSDLSFNFTSLAAQKILQGDASLNSIDTLVELNINQEKQQTLMRLKNDARMLAQAGVVGGGETPDGGKVMTDFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH50</accession>
    <name>A0A084WH50_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP008403-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00017751</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH50"/>
    <dbReference type="STRING" id="74873.A0A084WH50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017751-RA">
        <property type="protein sequence ID" value="ASIC017751-PA"/>
        <property type="gene ID" value="ASIC017751"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017751"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000741"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006803"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009700"/>
    <dbReference type="OMA" id="GCLWNDE"/>
    <dbReference type="OrthoDB" id="7721714at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785030" evidence="10">
        <location>
            <begin position="24"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="337"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="694"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB49544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017751-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="892" mass="100394" checksum="D27C8BF77BF85FFE" modified="2014-10-29" version="1">MAANRVKLLRAVLICQLITIAQFIGSDCHLRYYKYGEGPEPLPAFGQPAYLREFAHMAAVGWTKPDGSIGWNCGGSLIWENYVLTAAHCAADDENNQPDVVRLGDIDLYNDTDDQYAQQLKIVEIIRHPEHRFSSRYHDLALLRLEKNVVLHDTVAPGCLWNDEEIPFPSMEATGWGATGFGQNSTPILLKVSLSVVKKAECDRQYRVGDRGLKQGLQNYHLCAGDIKMDTCPGDSGGPLQIKLLHNAKMTPFVVAVTSFGSVCGKSVPGVYMKVSSYIPWIRSELAKRGEKIEEWSFKPYACALRYVNLREYEDDVVISKSASFETLDSSKAHMNIIKSTQTVKIHWPPVGQKAPDDCYGVVIDEDTVLTLARCAVFERSRASYIVHNDTRNEVVNVYRHPMYTPGSYYNDLAVLKTKNRFKLSRKFVPACIWSAFDLPDPKFYVTGQGRLDINEFNYFSKKMTEFKPQIVQLSPRADIQSAGNCSIPEDYLPGLTRGLTEEHLCFGNKPFLVPEACQMQFGAPLRRKIWRTRRHFEHIYGLNLFGKDCGFGRSAVATRLGFHHDWLKSVLLPNYRDNSDAVNFFNKDLDELDHCAGVDGSAGLCVEVSRCPKVAYDIGVNRNVRFCGSNSVVCCPYHNIKNQTTEASAELDDCESRYKSFHREYTYDTGRIDQFFHTVYIGHQTGGQTSWPCTGTLIARNIVVSSAYCLTRGSAPPNVVNIAAGAPNVTRSRPQVVKIDAVAIHRGYDPKTYRNDIALVRLEKPIVPTAEKYPICLWQNDTHTPFRLQRMVRDDGEVRFVENYPKYNTDCQEFMNERGGRKLSGTEFCTDIDVPDVASISGDPIVWSRLNKADNTTTQYLVGIISFGNAKEQLGVNTRISAYVGWIKSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHS7</accession>
    <name>A0A084WHS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP012308-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00017786</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHS7"/>
    <dbReference type="STRING" id="74873.A0A084WHS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017786-RA">
        <property type="protein sequence ID" value="ASIC017786-PA"/>
        <property type="gene ID" value="ASIC017786"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017786"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013524"/>
    <dbReference type="OMA" id="FTCYSVK"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000008">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="6">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017786-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="341" mass="38400" checksum="8F0861A17625891F" modified="2014-10-29" version="1">MRAILALGVSPDRILFAHPIKSTEALAFARAQGIRRMTFDNEYELEKVHREYPEAQLVLRIRHDSDRVLIALGKKFGCDARGDGLRLLARAASLGVEVIGVSFHVGCGSLDADCFYRAIESARLVFDYARQELGVHLKLLDIGGGFPGDSDKPINEFALAVEKGLHDFFPEKTVEVIAEPGRYYVGSAVTLLSTIQGKKVIRAGDRIEQIMYYINDGVFGTLFDWLSLRQINDLERAVPVVRPEREQEQSYRTTIWGPTCDSTDIVCEDVDFPEHQIGDYIVFKNLGAYGMTFATNFNGFPKPTVQVYVKEDIWDMLQSIAGTNWREKTLSFFERMQPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHW8</accession>
    <name>A0A084WHW8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017831</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHW8"/>
    <dbReference type="STRING" id="74873.A0A084WHW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017831-RA">
        <property type="protein sequence ID" value="ASIC017831-PA"/>
        <property type="gene ID" value="ASIC017831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017831"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022858"/>
    <dbReference type="OMA" id="NCCNIYH"/>
    <dbReference type="OrthoDB" id="7740893at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017831-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73070" checksum="A70EE50A37A5659E" modified="2014-10-29" version="1">MWQLLNQFPVPLELKDGIIYCQRALRDCVVQHQRVKVKELLLELEEEMLEIGDEQDSLVRTLSQRLQAFRAYVQQKTNVNITDDIANGYVTRVLHCHNETTGTIPTPASCSNRLSANELAQKYCLENIAKLEKFINDDNANFAPWSTGTAHEQRTEEKKCKKIDTKSLKAKANLCSSSSSSSSPSPVVTTGSRSLLKPKQERFPQGSTTSEPSSKDGASEPRAFASVIKSEESKDVKVTEVKNESSSNQATTAILSKKEPESTDEKPEPQKPQLYTQTGKRPWMPGLRGRPPKGVKYIPAAKHALQAAQRENYLRRMQQAMLGVKQRGRPPKMPIVVPSPPAEPEPEQHDSSEEQSASGSFGRPSVAVRRGRSNLQMALNRLKRLPDGENTETFINRTATEIAKKSKPTTGGKQGSSGSSGSSPSSRSSTPTLSQARLAASDDSSDRRCDMAPPESPPTKEPEVPPPNDIWELGMKALLNYFGLCTPEEAKARRERRQERKRRSCYSTERKDFHYGRLDYYEQQQLQAAVRTSKRPNQRPILYSPPVAVVKKRKHPMGAVPGAAALANSNARQRPPPMRCRLSLDSRDIFAAMARRSCFVCNKTGSTIELSACTNCCNIYHISCHRNEAESDLQLFQLRDNLCPVCLTAECGDDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WII5</accession>
    <name>A0A084WII5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WII5"/>
    <dbReference type="STRING" id="74873.A0A084WII5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018073-RA">
        <property type="protein sequence ID" value="ASIC018073-PA"/>
        <property type="gene ID" value="ASIC018073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018073"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001492"/>
    <dbReference type="OMA" id="IRKCCFV"/>
    <dbReference type="OrthoDB" id="27842at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF193">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018073-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="642" mass="73878" checksum="D4DB8D772038AB61" modified="2014-10-29" version="1">MEMSIESWFNLHYYGFGHDGEPLSDGEEDEEDIESGTPEEPIDEIDDREFPFHDDVFYINLKGPRVRTGFDNLPMEILINIFRFLNAVDRDSAALTCKRWFDAMGYRDFLDEVCFHFEEVTICDATPPIELFLHSFRHFSNIKMTRVTFNGYCEFWDIFGDYIREITFSNCPNVTKSKLTMILKRLPFLECLVLEECDELFKSWTPVDKKRIEPNCKNLRKLALRKNNAFTVDHLDYLIAMGPNLASLEVSKCLKQIDAPTRVKILTTILAIMERRKKKLKSVDFSYTMYDDLFLKQFAEIEDMSLSQISLSFFERAPIKDPGIIDILRCQSNIVHLDLSSFLNLTDFALIEISNSLHLLKTLKLNGCWLLTDFGVESIYKLDRLRVLDLSDCDKISDRGFMKAIVDRKRDCMNQLFLSMLPGLTDGVILKICLTLLNLTVIDFCGSDCMNDTSVQFLFCYLKCLRILRLNGCVKISDAGLTGENLAVAAIEMWDVQTTFSISDLRSLQELQLSGCFKVTDITLMHSFRFRELREVNLAHCVQISEPGIEAMSLNCPALEQVDLSDCFHVNDRCVESLSKNLLRLRLLKLVRLPLLTGASVDSLVNNCRALRYLHIRGCHKLPKDSAERLKKIPTLRNIPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJD0</accession>
    <name>A0A084WJD0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005068-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018592</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJD0"/>
    <dbReference type="STRING" id="74873.A0A084WJD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018592-RA">
        <property type="protein sequence ID" value="ASIC018592-PA"/>
        <property type="gene ID" value="ASIC018592"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018592"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004711"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF7">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018592-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="25382" checksum="358A49E10BEFFA3C" modified="2014-10-29" version="1">MLTTTTDESDALQPYFDFDVNRNLTITVGQTGFLHCRVERLGDKDLLRPANSVNWTLQIKYPQTRDSGVYECQINTEPKLSLSYVLNVIELRARILGPSDIFIKSGSEITIVCVIQRGPHELGLVFWYKGSSLLEPHTQENNVHPSDEGRITIETDWTDVLTSRSQEDVPKNKNNQNLNAADAIGSTRKMPCWNITKKCPTRLKWFVGGGTFDRYFVSRTEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJL2</accession>
    <name>A0A084WJL2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP005747-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00018433</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024038">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJL2"/>
    <dbReference type="STRING" id="74873.A0A084WJL2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018433-RA">
        <property type="protein sequence ID" value="ASIC018433-PA"/>
        <property type="gene ID" value="ASIC018433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018433"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008369"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF93">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB50406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018433-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="478" mass="52938" checksum="B8EA94838F796522" modified="2014-10-29" version="1">MYMKRALAARETLNEVDETHASSSSTTAPIWKHFTSINNGIAAECVYCSRQIAITNGSSSSLEMHLVQEHPNILQHAEQVSSPREAAKESSHKPATKTFGPTSSTMSQTTLRNETEEYSLKSHSHPQDISATLANLYINDRYADVMLLTCNGEENYTIPAHKFILGSSSSYFANIFDKSIVPSNAMTYIVLPPDLTYRSVQVLLQYMYTGESTISNDILNEVLRGGEILQIRGLCANERGQICRTGGNTGESRVGKKNPQNNQPRQNNQKQRTNDTQHTLNVRGGTEKSSSLPSTFQEHHDSTEEFNFINVKMENVEWSDYGTGDSGRSAIDVLPTELNNSELIISESTIKLEGCTAEASRSPTPSTEEPTSHGSLACELCSERFTAPSEFVRHIKVHTDMVQDHPSKRPRQEATSNDETDPLKCALCSTFYPTPAEWILHLQNTHTETELAVSSNRTVSPETRPSLSREDSAGKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKG7</accession>
    <name>A0A084WKG7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">17S U2 SnRNP complex component HTATSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ZHAS_00018752</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Within the 17S U2 SnRNP complex, interacts (via UHM region) directly with SF3B1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with (poly-ADP-ribosylated) RPA1; promoting HTATSF1 recruitment to DNA damage sites. Interacts (when phosphorylated) with TOPBP1; promoting recruitment of TOPBP1 to DNA damage sites during S-phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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            <dbReference type="EMBL" id="KFB50922.1"/>
        </source>
    </evidence>
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            <dbReference type="EnsemblMetazoa" id="ASIC018959-PA"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="117" mass="13093" checksum="77C133306B26401B" modified="2014-10-29" version="1">MLLSSPEAGVRVLLALKSPASKLATRAWKGCSAHPDAVTKQPTRALSAFGGETRDLRTRWRRPHHPTASADTVRRRASPFHTPRSFHVSLLPADPSESLRQAGFRYRTYEIESEFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
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    <name>A0A084WLT5_ANOSI</name>
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        <name evidence="8" type="ORF">ZHAS_00019439</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
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        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF77">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="1253"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019439-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1402" mass="155773" checksum="12DEB8AAA8C627EE" modified="2014-10-29" version="1">MPSPNENKTPNRMPPEARTAIKAVRALVSSLKETSTVLSVMRDYRAMEGEPLPFRKFGFNTVEDFLRASGEFVIKQAPGDATRIYIKPNSDSAHILQMVSAQKTSGSAGGGRGGAKRFVALRQPTAPSLSGRGFGGGATQYSRIYQHLPYSGRNNGNSSVSPKKISFKLNPPATTTAASAKTTNRPILKAQQTNGSTAAGGGKETNNNNKTTKNLNGQQQPQQAKLPSTDLRHVLNERNGNGQQQQAKLPSTDLRHVLNERNSILSRSSVEMRQPSKALPLSITISNNVARKLPFSVSDKTPAAKQQQVKQKVVQQYHQNQQQQQQQQPARKILPLMTIDVKPPETLGAATPSSSFSSTPAKSVNSRLMLAKAAMPSATAQEQTPQTSNPPSNNNFQRAQSLDERAPTTPSNHVPTAVRNVPQQHMMTTPYSPFGIVPLPASLPGKKSLQDRLKANQQLDEKDQARLPLPQQQQEVQPQPPNPFERTVSIPDTNIAPSLSLSEQINAFAPTTKPTTFSWNDPNATPVELLVKYSCYKGYDRPEYRYYRQKNGRIQCKVTLNGSSYTTYPADYGNQFEGQFAAALIAIEAIQRDESRQTYSVCLDSDPDIATTIYELLVPCRSGMFSKNIPDAFLAAHHELLPDHWFSIIDRYSNQLFQLEETSADTIVLARPQPSGSDVESNTSEARQMAMNQLPLPWNEQYWNLYITNPVSTVEVWARLVGPEYSDKMDALITDIEMSMLNCQPKAEELVAAVGEYYLVVITDCWYRVRVDEINYEANQCQCFFIDIGEREQLALDALYPCDPKYLQLPGQAKCFSLDGLEDFSEYPKGKHHLQDLLAGRVFIAQVLTKREDYEAAEQSDGPGTCTLKLMLYDTSTQNDVLLNPIILTRICDDTPTPELNLKVVNYVTISYVDDQGDVYCQKAGNMKYIQKLITNLTQSNALEGEYRGLYTSTADTTLLHQRLYLVQDETDGKWYRAALDAKESGPYCRMLYVDVGCRRRANVSNIYRLEMISLALNRYPAQAIRMRMFELPDCSEPQVLARLRAFLRPAMPAMAKVFGMETGILPLVKLYVHVADGGDEGKKILVCVNEAIKIEQELEINSELINSPRVAEGSIPSSSSDTDTTVGTVHSQSSAGYTLSSADGKDLSNRFDGLNLSQPLSSSPEISAKKSSSTPTASTTTTPNGERKEAIAKLAKVTLPAVGKLFDVKVTIASSPKFFIIQPYAQAKQLDQLMQELQKFCMTKAQPVRKDQVRQGEAYAALNRDGHWYRVTVVNIILFGPTPIHAYFCDFGLVAMLDVANLRVLPAKFRVLPQQAVKAKLYGVKPINKDWVTADAVRFQELTAERKFASVVRKVEEDEFNRHEELVELELIDVSTDDDILIHKVLVDEGRAIYTAEAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM57</accession>
    <name>A0A084WM57_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 21">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 21">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ZHAS_00019353</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Associates with the precursor of the 40S ribosome subunit. Interacts (via its N-terminus) with PRMT5 (via its N-terminus). Interacts with WDR77. Found in a PRMT5 complex composed of PRMT5, WDR77 and RIOK1. Interacts (via its C-terminus) with NCL; this interaction targets NCL for PRTM5 methylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 21"/>
    <dbReference type="EMBL" id="ATLV01024388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM57"/>
    <dbReference type="STRING" id="74873.A0A084WM57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019353-RA">
        <property type="protein sequence ID" value="ASIC019353-PA"/>
        <property type="gene ID" value="ASIC019353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019353"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009093"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="26">
        <location>
            <begin position="167"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="22">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KFB51301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019353-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="574" mass="66150" checksum="F7C364119C893DA6" modified="2014-10-29" version="1">MSAGQFEDALEDATEYLGVVDLKEKLKSTVPTSKVNGASPAVTRIEIQDALFGTGKNEGEKEQWEEYDYDYYDDDDDDDLDDDNFYCYEGGEIKRNQQLNLQQSHTNTQSVSQKVSHFQPADTLFKKFTNRINVEKYDGPSSLPSHAKNTLIETQRKADSDRLRSKDKQDRATVEQVMDPRTRMIVFKLLNRAMINEINGCISTGKEANVYHATSSSGMDYAIKIFKTSILTFKDRDKYVTGEYRFRHGYNKHNPRKMVRTWAEKEMRNLVRMKKCELPVPEPILLRGHVLVMEFIGRDGWPAPKLKDVELSTSKARELYRDAVVMMWTMYNRCKLVHADLSEFNLLYHEGKIIIIDVSQSVEHEHPHALEFLRKDCTNVTEFFRKRDVSTMTVKELFDFITDATITLETMEGCLERISEKIANRSFDEFTELQKIEEAVFKRIFIPKTLHDVYDAERDVFEKREEDLVYKTITGLGAVEKQSSNQPVVPGTALDAKDGNSSEESSDSEHSSNDEDDEEDGNEGKGSAVSVRAKDETAEERRARKKAVKDEKAEKRKTKVKKHIKKRKEKMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM70</accession>
    <name>A0A084WM70_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP012132-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019367</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WM70"/>
    <dbReference type="STRING" id="74873.A0A084WM70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019367-RA">
        <property type="protein sequence ID" value="ASIC019367-PA"/>
        <property type="gene ID" value="ASIC019367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019367"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010190"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023355"/>
    <dbReference type="OMA" id="TMAPTRY"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785139" evidence="6">
        <location>
            <begin position="18"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="452"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="561"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019367-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="622" mass="68313" checksum="FCEBFD7DFE348D12" modified="2014-10-29" version="1">MLGSVFILSGAILVAAGATIDPRCSRYSQGMEAQVLPYLPDCRKFVICDMGGNGQVLSCPKGLYFDVESHACSYEKDSCTHGELAGEADDVVPQVPVKPQPQVPVKPLPQVPVKPQPQVPVKPQPQVPVNPQPLPIQPNPLPVYPKPVQPIQPQPVPVPIQPPNFIPPVVAPDSKPLGPNILPIVTAPTTLAPIAEEQPDIHQLNICKDQAAGKVYPVSHDCGLYVVCMGNSKAIVQRCPKGLLYDGKQQRCEFASASFCATPRIDGNVVLDMHGVDMSLRTDDDESLDTPDYAVPVKPVEVIVHQPLEVIHQPQPILIVPEPEQKPEAVVENKFRIIDNHPRCLGRVNQALTLELPHETDCSKYLVCVGRTAIEKQCPPGQHWSAKNNWCDFVSAAGTGCNGTRGRSSRWYSPSTPVDNAAMDGRRCAFSVALLVGLALTSVQAAVTVTRDSRCPRVDDPEKTIHLTHPTDCNRFLVCSSGMAYEMRCPEGLEYDTEQRSCDYDYLVRCSERGRTQIQQANQPFEMPSGQLLLNRPAWNDPQEEPRVEAQQYKAPVSVVDARCPRTDDPMKPIHLPRTGNCNKFMKCFGGRAYEMDCPAGLEFNAKQNRCDYASLAGCSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMW8</accession>
    <name>A0A084WMW8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP006798-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019630</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMW8"/>
    <dbReference type="STRING" id="74873.A0A084WMW8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019630-RA">
        <property type="protein sequence ID" value="ASIC019630-PA"/>
        <property type="gene ID" value="ASIC019630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019630"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000486"/>
    <dbReference type="OMA" id="ATNKPHD"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019630-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="29374" checksum="2358E4214D162668" modified="2014-10-29" version="1">MSHSRSYNYYEGSRSRSRERKYRRDYREESERYNVQPSSSSHAPTDYSASRYRRSSHQRSSHYHDHPSSSSGCPSYAQSGKVVLAVFNLSIYTTEAELYDIFSKFGPLRKTTVVLDAKTGRSRGFGFVYFESAEDAKVAHDQANGIEIGDRRIRVDFSATEKPHDPTPGVYYGKVSHPKSSFGGHPAGHPGMSSGGGYHHCRACEVEARDRERWERETRARDYYYYDSYSSHDRSRDRSSTGRSGRGDYYRGGTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNE1</accession>
    <name>A0A084WNE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007513-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019826</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNE1"/>
    <dbReference type="STRING" id="74873.A0A084WNE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019826-RA">
        <property type="protein sequence ID" value="ASIC019826-PA"/>
        <property type="gene ID" value="ASIC019826"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019826"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015456"/>
    <dbReference type="OMA" id="HMQEHDK"/>
    <dbReference type="OrthoDB" id="7731522at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB51735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019826-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="480" mass="55957" checksum="4DAEF12B5FC35D61" modified="2014-10-29" version="1">MEPSDKCTICFSTSESDYLDIFAKDNVSKNMAAVIAKHLWFEEIEQLHHQQQQQQQQRPASRSNGKARSESPAPLQGPTYKTEFLEIKGEPLEDEEDEARAVDAIDGELDEKAESNETIKSEDSDEFECDSSSPSDDEVKRRSKKFTTGARSRKAYKKDRSDGSLKKRKAGGRVSVHPDEDKAILQFYKRIVCEVCDNQRMIVGEPVMEFLTWGALLRHTKEVHGHYKIFVQCPVCEMKLRTKVTLWQHMDMHTNPDKYRCEVCSEVHQNMKEHMQNKHEERQFSCDLCGSKFPFKKRLVVHMKKMHAEKDVRCDQCDKSFVSFRLLIEEEGTIWETNLRSFLSSSFTKYTIEDHRRSVHMARFVCEHCPKTFKIRFRLQKHMQEHDKSLRTSTSVPCPTCGQVMGDKYILRQHIRHMHAERQAVDCETCGKTFKNKRNLTVHLANVCMKPAQIHTCTICDKQFRHKNKLKDHMSCCIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPA4</accession>
    <name>A0A084WPA4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004428-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020232</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525367">
        <property type="protein sequence ID" value="KFB52048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPA4"/>
    <dbReference type="STRING" id="74873.A0A084WPA4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020232-RA">
        <property type="protein sequence ID" value="ASIC020232-PA"/>
        <property type="gene ID" value="ASIC020232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020232"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010347"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000025">
        <property type="entry name" value="Midline fasciclin, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000023">
        <property type="entry name" value="periostin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="82"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="232"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="43426" checksum="63FF8EB220482F10" modified="2014-10-29" version="1">MAAADGVKTSTSNMLNERLEFEYAAGDADSMEPVTEGLPGTDGASKPTQRIRINGQATIQESDVMASNGVLHVIDTVLPTDSGMPISTTLANHNLTIFKQLLVDAGLEDEFDDMSNRTFFIPSDQAFEQTEAGRYWIRQLKEHPENLRNNAALREFLEYHVVEPLIKTCSLEEKMLPTKAAKDVRVNLYTTNPLFSTVMNRATVNCARLVHFNEETCGSVVHQIDRVLDVPKMNLMEALAANPDYSMFLCMVSATNLTELLGSSEDDDVFLEVNEWYQETLQNKDELERIIRAHVLPNVICCTGIVPSEWPFVRTTETVGGNQLRLNRSRRPEIENAGITKCDIVAQNGIIHEINDVINVQAKRGTVAPAGSNTFPSFGSLARPLSFWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQK8</accession>
    <name>A0A084WQK8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020747</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQK8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020747-RA">
        <property type="protein sequence ID" value="ASIC020747-PA"/>
        <property type="gene ID" value="ASIC020747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020747"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="12603" checksum="86A2CD46FE6B2A9E" modified="2014-10-29" version="1">MALRSLSTNETSHSAPPHAGGGHWVTLPAPIGGPRCNTPDCPINTLRAVPGRRLEGAIVTPYRKFVEKPRHLTVVPHWKAPDAGAGVDRSKVGLPASPIRCQLGSQWRHPLNLELPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR29</accession>
    <name>A0A084WR29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003710-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020928</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525402">
        <property type="protein sequence ID" value="KFB52673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020928-RA">
        <property type="protein sequence ID" value="ASIC020928-PA"/>
        <property type="gene ID" value="ASIC020928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020928"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007471"/>
    <dbReference type="OMA" id="RFNNSIM"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF1">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020928-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="427" mass="47204" checksum="AFCD2A010E9F5448" modified="2014-10-29" version="1">MSGSCDKDATRSKFDERRRAYGQRTVSDDDGDESDTLTEFSRESLTSSQGRSSIGSIPWAEDAIKQNQTEWERIDRMFYGEEELPSDPKLREEILEWTSVFPFLRLTGKSLSIEESEHVKGNDPFHEEILMVDPPLISRTRSSRSGKDGSSKHTTKDIDCALTCCELDKCLYISSGSTIRQNNQPNVVKPGRRSGTDLAPEYLDRNEKPYIKVKPLNSLMVPQVPIVPIGSYGLLISNHCVGTGSYLSSSRNCSAQSVSHSSHGGVDGHTYGGRSRNGNLQRKLAPLPHRPQQQQPQQPHKPSKTIETTILSASASATHNRVPPLAKNYKFLVQNSRVAPTLLAEIEQRHHTKLNVVKSATTRYMASSPTKHIFALPSLAGIDGLTHHVRAPGGSVLQRSPNKKRTFRSEVIGRSISAAVTQKGNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRG8</accession>
    <name>A0A084WRG8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00021082</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01026054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026055">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026059">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525405">
        <property type="protein sequence ID" value="KFB52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRG8"/>
    <dbReference type="STRING" id="74873.A0A084WRG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021082-RA">
        <property type="protein sequence ID" value="ASIC021082-PA"/>
        <property type="gene ID" value="ASIC021082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021082"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013163"/>
    <dbReference type="OMA" id="SANICNW"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000144">
        <property type="entry name" value="Chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF144">
        <property type="entry name" value="CHITINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785095" description="chitinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="397"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="836"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021082-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1226" mass="138773" checksum="C9EBF378E6B259C9" modified="2014-10-29" version="1">MATSATALLTLLLAMTLALQSSLAERRMICHYTTWSQGRANPYSYRIEDIPGHLCTHVVYNFVGVDSEEYELTTLQREIDIVQNGFGRFIDLKQRFPDLKLHVAIGGWDHGGERFSKMAAYRQRRQKFVTSVMKFMSQYGFDGLEIVWLYPGNEDRGGAKIDKDNFYYLISDLKSAIRKAKASWEVAIQVPADHTRLELGYQQDALCEIADFVHVIGYDLRGSWTGFVDVHSPMRDRPHDQGIYAGMNVQNGVESWLQSGCSPDKVVLGVPFLGRTFLLRNRVENSLGAPARGPGPKGPHTYSEGYMGYFEICEKFKQGNWSQMWDAIGLCPYAFRNFQWVGYENERSLQEKAQWAISQKLGGVYAFSLDLDDYRGTCGEPYPLMNAISKIIKRSNGNNIVHGRPKEYSYQIEDIPGELCTHVAYNFVGVNEDTSELVSIKPDFDDVQDGFGRFRDLKKRFPDLKLIMTVGGWTHGGGPFSKMAASRQSRQIFVASVVEFMERYNLDGFEIVWLWPGAPERDGKKQDKDNFYYLVDDLRHGFQRAGKPWEVSVQVPVDRARLATGYSQESLCDPGAKATGPGETGPFTNDPGMIGYFELCEKFKDGNWTVAVDRTAQCPYAYRGNQWVGYEDEQSLEEKSKWVTEKGLAGIYVYTLDLDDYRGKCGAPYPLVRSLHKFIKNYPKSDEDFNFAIYRTHRQVPTRARIPPTTTVRVRLLVVLRRESQRSLTYVFRLSHRAADYVYITGYDLSGPWNGITDVHSAMNKRVFDSGVRRDLNVKGVNIGSSLSVNILEKSSAAARFQLKMSITHVRQLISVVLLVHLTLLGPSTVRGDGETRLVCYFTNWSPQRPGEYAFNINDIPVDLCTHVSYTFAGIDEDTFELKSTVPSFDIVQKGYDKFSKLKNNYPDLKLSLAVGGWAHGGEPFQKMASSLESREIFIASVIEFMHQYDLDGIEMVWLWPGSPERGGTTSDKDNYHSLISEMKESFRRAGHESWEVYVQVPIDQYRLELGYHQRQLCTAADYVYITGYDLSGPWNGITDVHSAMNNRVFDSGARRDLNVKGGVQNWINNGCPANKIVLGVPLFGRTYTLQDESNHGLGAPITGPGRAGPYTNDAGYLAYFEICTAMRESSWTTEWDERGMCPYAYSGNQWVGYENQTSLEEKASYARHKGLGGMYAFSLDLDDYRGKCGTAFPLLNALRTAFKPKNLCSDTIVFALYRESCDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS73</accession>
    <name>A0A084WS73_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003060-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525410">
        <property type="protein sequence ID" value="KFB53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS73"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021363-RA">
        <property type="protein sequence ID" value="ASIC021363-PA"/>
        <property type="gene ID" value="ASIC021363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021363"/>
    <dbReference type="OrthoDB" id="7779135at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021363-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="11829" checksum="0AC493C676FA20AE" modified="2014-10-29" version="1">MQMKAKVSVQTFLAGNGLIDLSIVRSQSVNELWPPRFVEARCINGFTVFFAFVLAVATVAGQRFGFPQTSQFGLASLTGDFGGPTAFGGQDLSGTLNAGVRDPRQNRGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSL9</accession>
    <name>A0A084WSL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP003221-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00021520</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01026618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WSL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021520-RA">
        <property type="protein sequence ID" value="ASIC021520-PA"/>
        <property type="gene ID" value="ASIC021520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021520"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011666"/>
    <dbReference type="OMA" id="KNPRQGA"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="220"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="497"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="805"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1407" mass="156984" checksum="37982C13A7B72FA0" modified="2014-10-29" version="1">MDSSRKPVKRNPRKGAFCLSQLLFGWLLPLFYRGSRRGLGKDDLTKCLKADRSEQLGDRLEEQWERELSQARIANRNPKLRNALFRTFYKQCLFDGFLIFLFVLIKTILPVVLAQLLVQFQEPTNATHVAVPNFNDSFISTLPPMAMPLMMDPQTTRSQLENLVFDETAMINKRRRKRKISDVNGASSNAAGNSIDGGKPAPNQDEVGANQTAFDDLSDFLHHAWNDAFWLSGLLVLLTLFGCFCSHHSDLRERLIGARMRIACCSVIYRKTLRMSKKAAGQTPAGYMINLLSNDVSRLDYGFIYVHYVWVLPFQACFTCYLIWRRVQWAAIVGVVGLLVKTIPVQTGLSRLSSIIRMRVAKKTDQRVGIMNELIQGIQEVRQIRWASYIRGIYLSTMVFTERSTLFLAIACCVIEGRAITADIVFPMAQFFNILQLTAAIFYPLAVSLGAEALVSIDRIQEFLALQEHDPQSASSGLKRNLNELHQSTEDPTRPALELQNVTASWEETTEKTLKDISVSIGTGKLLAVIGPVGAGKSSLLQLLLGELPIQNGTATINGDVSYGSQEPWLFTGTVRNNILFGLPYDRQRYQAVVRHCALTTDFQQLPDGDKTVVGERGTSLSGGQRARVSLARAVYNSASIYLLDDPLSAVDSHVGKHLFDEVIGPRGYLAQKQKATRVLVTHQVHFLQEADWIVIIEGGKIVTQGTYTELANGKVDFGKLLNCGGKSPSEQEEDMLSSEIPEDEIPFIDGVTLDGYKLLKGSSVSLRGATPNSCASSVAENLGRQVAEDQAEGSISWRVWATYFLSGGNILMLMFTLFMLLFSQAIVSGSDYFVTYWTREEEERLTNPGTVHTSTVDYLYTYGVIIIGVVLFTIFRGYLFFNICMKASRNLHDRMFARILTAPMRFFDTNPSGRILNRFSKDMGAIDELLPKAMIEAIQILLVMSGILTMITIVNPLLLLPLLGAVLLYAVALKLYLRPIQDLKRLEGITRSPVFSHLSATLSGLSTIRSSNAQEKIREEFDDLQNVHSAVWQLTMASNAALGLWLDCISTAFVACVTFSFIVLHQDTYSANVGLAISQALILTGMVQYGIRQTTESIQQMTAVERVVQYTEIPSEQDPPKVPPGDWPWKGQIQFHNMSLSYEQGMPPVLKNLELVIEPTWKVGIVGRTGAGKSSLIGALFRLARIDGRIMIDGIDTGVISLEALRSKISIIPQDPVLFSATIRYNLDPFSLYDDDMLWRAISEVELRSSISGLDYMVTEGGTNFSVGQRQLICLARAILRNNKILVLDEATANVDPQTDALIQKTIREKFKHCTVLTVAHRLHTVMDSDRILVMDAGVAREFDTPHRLLQQEDSILKDMVDATGPSESESLKRIAAETFARMDPNRHLMNDMPNPWRFSKESASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUH2</accession>
    <name>A0A084WUH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP010767-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00022309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUH2"/>
    <dbReference type="STRING" id="74873.A0A084WUH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022309-RA">
        <property type="protein sequence ID" value="ASIC022309-PA"/>
        <property type="gene ID" value="ASIC022309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022309"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="185" mass="20652" checksum="C847E80602258552" modified="2014-10-29" version="1">MEIFPHQINTPRREGTEVQVQGQLRLTRSRSSSVSEGRSPVHNQSSRIPTTQNGSAASPRQHQQSQQTTPQQQQQSQNHQQQQQQHHHHQHHQSPQRPQTLTPTREAAANGSMAMQTLVLTVHKDATGYGMKVSGDKPVFVESVKPGGAARRAGLMPDDMILKVKCHALEEEGNLQRTCNKDRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUU0</accession>
    <name>A0A084WUU0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022235</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUU0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022235-RA">
        <property type="protein sequence ID" value="ASIC022235-PA"/>
        <property type="gene ID" value="ASIC022235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022235"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11759" checksum="8F3520FE8A9AC873" modified="2014-10-29" version="1">MLPNFKPEMAGTAAKHGTTETLAKCQDTRETFCLPQNRFGDSLLSVRSHLCDSITTALCTLPLANLANNCTSPSVFHLHSSGFLEATVPRTPALETSGLRLERKVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>V9QP75</accession>
    <name>V9QP75_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CPA-IV</name>
        <name evidence="18" type="ORF">ZHAS_00013610</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-09" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterization of eight carboxypeptidase genes cloned from Anopheles sinensis and their expression in relation to blood feeding.</title>
            <authorList>
                <person name="He Z."/>
                <person name="Zhi Z."/>
                <person name="Chen B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KF707630">
        <property type="protein sequence ID" value="AHC32032.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="V9QP75"/>
    <dbReference type="STRING" id="74873.V9QP75"/>
    <dbReference type="MEROPS" id="M14.A11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013610-RA">
        <property type="protein sequence ID" value="ASIC013610-PA"/>
        <property type="gene ID" value="ASIC013610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013610"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021623"/>
    <dbReference type="OMA" id="RASVDMY"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF123">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010849280" evidence="15">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="120"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AHC32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB45619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013610-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="418" mass="47264" checksum="5B59D47D9789758E" modified="2014-03-19" version="1">MEIKISPVVLVTCTLALLAAVDGKLRYENYGVYKIDITNADQLTLLQKLESTPNGYTFLEYPAQVNKSVEVVISPSEKFTAERLFKKHSIGSTLLTSNLQQILDKERPSRRKLEGFGWDDYHTLEEIYEWIDGMVAQYPSVLSVDTIGQTYEGRDMKVIKLSYKPGNVGIYIDANIHAREWITSATITWVLNELLTSEEPNVRFIAENYDWYIVPVANPDGFAYTHTTERLWRKTRTQHNLLCYGTDPNRNFNFQWNNGGTSTTPCSDTYSGPAPESEVEVSNLTTFVRSIAANVKLALSIHSRGQYILFPFGYNNAPRAYNYQDLLQVGQRASVDMYKLYNKPYRVGTTADALYVASGISVDWAFAVAGIPLSYTYELRDQGEFGFILPADQIVPNGEELLEGFIAMIDEARVLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VA84</accession>
    <name>A0A084VA84_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00000548</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01002860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524094">
        <property type="protein sequence ID" value="KFB34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VA84"/>
    <dbReference type="STRING" id="74873.A0A084VA84"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000548-RA">
        <property type="protein sequence ID" value="ASIC000548-PA"/>
        <property type="gene ID" value="ASIC000548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000548"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012896"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 8" id="KW-0186">Copper</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="9">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="153" mass="15737" checksum="30300154AA9D8960" modified="2014-10-29" version="1">MPLKAVCVLNGEVKGTIFFEQNAESEPVKVTGTVTGLKPGNHGFHIHEFGDNTNGCMSTGAHFNPYGKTHGAPEAEERHAGDMGNIVAEADGEAKVDLTVSQIALSGAMNVVGRSLVVHADPDDLGLGGHELSKTTGNAGARLACGVIGMCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB46</accession>
    <name>A0A084VB46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001186</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524276">
        <property type="protein sequence ID" value="KFB35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001186-RA">
        <property type="protein sequence ID" value="ASIC001186-PA"/>
        <property type="gene ID" value="ASIC001186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001186"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7227" checksum="68BBC5C81E982CDF" modified="2014-10-29" version="1">MVRTMSGFRSNATTYEEGFPNVSNVLSNRENIKAFLPAKEIVVSPIKVEFLQSLSDGSRQTSTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBR8</accession>
    <name>A0A084VBR8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP004178-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00002056</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01009141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524507">
        <property type="protein sequence ID" value="KFB35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBR8"/>
    <dbReference type="STRING" id="74873.A0A084VBR8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002056-RA">
        <property type="protein sequence ID" value="ASIC002056-PA"/>
        <property type="gene ID" value="ASIC002056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002056"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002459"/>
    <dbReference type="OMA" id="VETNAFN"/>
    <dbReference type="OrthoDB" id="10072647at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001826">
        <property type="entry name" value="Lethal (3) neo38, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000843">
        <property type="entry name" value="Potential zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001269">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="545" mass="57356" checksum="711B3B7F2B326926" modified="2014-10-29" version="1">MNFSAFGGPFSGIHQFAAKFGSNDGAFTSTNSPGNGAAGAGNGSGLGTGSGGVGGTTGGTNNIGQQQDLNRYHGGTNGNHFNQNTTSMVNAPMSYGQNISHAYGAANQQPANDHSFGNGNATMGGNDHQVKVPKGGNTLKVDRDEMINQQILQNVNQSWQTLTNPSNTVDYSSHLLSATLPISIQHFLKYSETIKKESNGSVGGSGLNSPGPLSGLIGVETNAFNVQKDLLNLKNGSNLNLALGNVAVSAAAASLGLNHQHLAQHHHQQQQQQQMHQHGANHHTDNGFASQQQQQQQTSLANNLTNGANGGGAGAGQTVVSSDAHNSSSSTVNGATANGEEVAAPVTTGKTKTKKQKKRKPPKEKKPRPKPGQIRETQALDGSPLFCCPECQMAYPERGLIEQHVISHAVERRFVCDICNAALKRKDHLTRHKLSHIPDRPHICSICLKSFKRKEQLTLHIVIHTGEKKHICGECGKGFYRKDHLRKHTRSHIARRVKSEMSASNGTAGGSGSGTAGSNGAAQNNSALAGSLMATNMQGAPVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC81</accession>
    <name>A0A084VC81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002425</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002425-RA">
        <property type="protein sequence ID" value="ASIC002425-PA"/>
        <property type="gene ID" value="ASIC002425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002425"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002425-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="7819" checksum="C63A669D0AA95708" modified="2014-10-29" version="1">MAIVVRALVRSWCCAGAAIVVSDCAELQVPRVPAGSASIPPGMLNKQMMVRVDAMLLMIRFLMTLTVFCVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCI8</accession>
    <name>A0A084VCI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP004093-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SCP2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002565</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524612">
        <property type="protein sequence ID" value="KFB35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCI8"/>
    <dbReference type="STRING" id="74873.A0A084VCI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002565-RA">
        <property type="protein sequence ID" value="ASIC002565-PA"/>
        <property type="gene ID" value="ASIC002565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002565"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003221"/>
    <dbReference type="OMA" id="INSMMAK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000009">
        <property type="entry name" value="Sterol carrier protein-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF32">
        <property type="entry name" value="EUCALYPTUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11183" checksum="F57F3D0E5C1FF270" modified="2014-10-29" version="1">MKCDAVIEKIKARVASIDPNGPRKVLGVFQLNITAADGVHEIVVDLKNLKVSEGKASSPDVVINLKDEDFIAIGTKQIPVKDAVAQGKVSMTGDQNLFQALVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEA3</accession>
    <name>A0A084VEA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003428</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB36297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003428-RA">
        <property type="protein sequence ID" value="ASIC003428-PA"/>
        <property type="gene ID" value="ASIC003428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003428"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003428-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7302" checksum="9AB674D563AB9FC9" modified="2014-10-29" version="1">MRFGAAQTSSGQLQVRQGVGGSANLLANSLGSDAAMSESIDSLHHSSHSPNSAFSTALDYIMTPLWMFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEX0</accession>
    <name>A0A084VEX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NAD-binding protein of Kef-type K+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003649</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524783">
        <property type="protein sequence ID" value="KFB36514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003649-RA">
        <property type="protein sequence ID" value="ASIC003649-PA"/>
        <property type="gene ID" value="ASIC003649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003649"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003649-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10389" checksum="F723B3C82F310C63" modified="2014-10-29" version="1">MGGKNQAIEVKRKHARDRRQDIRETGGMRRVTSAKEAKRLLATAGTTTTTTRSPASRFTVARRSVGRFRARALAVVATTSRRQNDSKWRFAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VF54</accession>
    <name>A0A084VF54_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003794</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VF54"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003794-RA">
        <property type="protein sequence ID" value="ASIC003794-PA"/>
        <property type="gene ID" value="ASIC003794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003794"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015086"/>
    <dbReference type="OMA" id="TEFRSIC"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003794-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1404" mass="151056" checksum="A33757B42C8A08AD" modified="2014-10-29" version="1">MKCSSCIGGGRRSLSSSDHESASPVTDGVTTADREYLAAHTMAASDSEKRDLLRAYRVDSPSAKNGPDSGAASREDDSDDYRPPSITIEELDDDVFEDCGEDPRMMAIKRKEEQEESVVMDPQTVGYTQLLLPPSLRAPLEVIREEELSDCSDSEFSHRPPTTTDADAKAGNVDSTVRRVDPPPTDMPDGGGTARGDAVAHGLAKFSPAKVLREILRYRRRRRSSGGNRKQPAPSAPFLHPGQERQEQTTCVLVGAKEADIAPQEYRSVCTTQTVNCEMMEVEVINIGSNSSSLDDLSDVDADTVEQVDEEQAYEKLELEDEHTTTISVHENRGEELTTSVSDDPANEQLDDPSKQLPYESITTQIIPDSQDVEIHPTSYEGVASSDPPLRLDNTHNSSLADHDLHQTEKNDENASPKSVVLQVVHTGSDGSSSSSDGIQQFVAPAHPATSPSGSSQISNADDDDDDDGDDPAAVACNDRDQQERNSSERTSDTDEKIPNENSRSPSTPAADDTTGDALLDISCSGVAPVDRDRDRASVVGIDDDESVTKASLNPSLSSSSSPSPSEIDRGTLIGVGTRVNHCVQNGERPPLPPPRTATIMSIEDDESISAVTVVKKGHRSPPPLPPVPAPRVAAIPLPPPPSVDGEATTTSSVTHPGRQPSVGEAEEGKDQEEKSAGSVAPPPPPPPAAYLVPLTVEALSASESSPQNGQIHSGDHSYQTDHADADQNSAQDSVDAVAAVDRSSPAVHTEEFKDDQSVLLKYMQEDSVSGSSNRSETIKSSDQVTDDGGDISEDFKQRQRTTGRPTGSYSSDPGESKEGHGPKIEPSSGSRRRGGQYLCDGFESAVVRRPQVSRSNDPVPADAASAAAAGMGVIPGPVEQNRLANTKGSSGGNQDSSSPEHKAALVADLRTEISRLKDAELQEEFLKLELETAKYERELQLITVPKRDPKVPNGVGGCGSAHENRTYFVSKQQDFVVERSPNNGAFGSSRMTGGGRLRANVPVPLPATDTKGPAENEQLYNEWQQKMEQREERRVQRVITTEQSFSQKQQQQRQDAVSVDIQPPSGPIPPPPPPTTDADEEIFTKKVKDRVRDLMASQAAAAEEARARQRGRVVSSAPSTPTARRKHIEEEFREFREIRQRETAAVSAALATESAKENARQLVEAVNHYAPSKIPLATSYKKAPALQRTTPVPAPKVTTVTINSNDQTTSSNNGAQSAGEEEIKVNVAALIATHQEKQQLQQVVPVASGQPPKVAPSRSNPDARPTEQVPVQDDCTSEPTVSVSDKCQQFEQRIRRNSDAGKVVDNNMAPTANRKPTTSTGATGHQQQQGRAGTTIGSYADSVECCDTKQRGFCSEADLLHEIDHALVLAKDFLFSRGMFHVLSPILALLDIACLRPTACSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFC2</accession>
    <name>A0A084VFC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007636-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003726</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFC2"/>
    <dbReference type="STRING" id="74873.A0A084VFC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003726-RA">
        <property type="protein sequence ID" value="ASIC003726-PA"/>
        <property type="gene ID" value="ASIC003726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003726"/>
    <dbReference type="OrthoDB" id="7985628at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8534" checksum="AF9DFD967FDF7C1D" modified="2014-10-29" version="1">MAYIVDQLYPPIKHIEEEDNEYTSFNYWREPVPEIDFDGCDISGSSSNGSASGSVPSEKLSPSAATIVQQALPTIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFW2</accession>
    <name>A0A084VFW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004030</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524800">
        <property type="protein sequence ID" value="KFB36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004030-RA">
        <property type="protein sequence ID" value="ASIC004030-PA"/>
        <property type="gene ID" value="ASIC004030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004030"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004030-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10587" checksum="FAA731D36C1215D7" modified="2014-10-29" version="1">MPDINNNGNNDDYRHIITIAQAPSSSQGSTKQPQPGQWQCFLRCSPRCSLGGTLRAVGSRQNHTLRSFPSIKNREETETMAAEWSTGVGNAFSSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGE7</accession>
    <name>A0A084VGE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004244</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524821">
        <property type="protein sequence ID" value="KFB37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004244-RA">
        <property type="protein sequence ID" value="ASIC004244-PA"/>
        <property type="gene ID" value="ASIC004244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004244"/>
    <dbReference type="OMA" id="PTHVGCC"/>
    <dbReference type="OrthoDB" id="9974612at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004244-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12708" checksum="8BA9A894ED3C46DE" modified="2014-10-29" version="1">MDFKASTTATIATIDKGSDRTFASAFFHPQASPTHVGCCVLNRAPARPPSEIYFESRGKCCKKLLRYNGYPNKVLLYPEEGWARSAASSYWTIAPCRWRRNRCVVEEVAGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGQ4</accession>
    <name>A0A084VGQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004362</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013049">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524837">
        <property type="protein sequence ID" value="KFB37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004362-RA">
        <property type="protein sequence ID" value="ASIC004362-PA"/>
        <property type="gene ID" value="ASIC004362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004362"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="12460" checksum="413E3EC0E3D78AC5" modified="2014-10-29" version="1">MDKKGAMQKHFGGVKPQKETRIWELGREVIPPSQTHPSTTPRCSKLVSTGKDFSSPLVCLFVDYGFLCFASSHSTIFISNIVIDIIIPPRTIGLHAGDDVQLISETLEFDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI46</accession>
    <name>A0A084VI46_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP007788-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00004878</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524849">
        <property type="protein sequence ID" value="KFB37640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VI46"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004878-RA">
        <property type="protein sequence ID" value="ASIC004878-PA"/>
        <property type="gene ID" value="ASIC004878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004878"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002451"/>
    <dbReference type="OMA" id="AGERKCK"/>
    <dbReference type="OrthoDB" id="9978677at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19815">
        <property type="entry name" value="Bbox1_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16631">
        <property type="entry name" value="mRING-HC-C4C4_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        </source>
    </evidence>
    <sequence length="3769" mass="415392" checksum="DCDB15104F000BAD" modified="2014-10-29" version="1">MDSGPAGRFRTARNMPSWVTESSDRVGPPPPPPPVIATDPEYEVIDVANQQYSNAPPPVPLKSPDIKRLTVMKCDLCGSVTPIVRCEQCDSNLFCASCDDRYHRHPKRQTHARKPIDPPPPAPPSTVKPPLPPKGEAGVGGPLPPPRKNKRPGSFHFPNQQQQQQQQQKPPPPPPSPALSLREKMNSLKRFIHPSNRPLPDPPENKIHSSNSSLDTVSKRSPSGGMSRSVSTTMEKIQNNTAATLDRMTLLQQRYRQHQETMKSGDGDRSRRASLTSNTDLQSSATESSNSFRSRPTSATFQQPHPQQQFLQVSPHAPGVGPMHQQAHLQQRWLNPPAPRIRSGSVASGINLLPGAPTGLTPALNASNAPPASVSPTQRSEFGDSPPMMPNPPRSLSTSVFNLHQPPPQQPNMWGFNPLHQAQSMAHFNPMQWNQMNAWMARGSQNGSNMSLNLPSQSPHGFPQDPSGYPPAWANAWGGMYPYPMGMMPMMPGVAMPPPRSRANSRSRAASPALSVKSRKSTMSMRNLNRNSFVDDLTDDEDSDDEFHRSRGRGSDRRRRERLNSTSSIDFDEPEPANHAFVRASSVKHSRFNRDRRGGGSSARSLIDYPVSRKPAAANRYEREEFPVSFLIARNASKQASTHPHKLYPFHSHKTLLVVLCPLVPNRKIVKQAHLGPRFSQVPSLLLSRTIELLLHSTLRNSCNSTTNILSKIKRIHPRLTFVVEIIPIERFYFVCTGNVMIDTDLVVTITTQKPNRYIELLHNRIKIASPFLCFARNHKLETKSKLEKDKQFAFRVLIRCRLFSCSLVLDDAGQSDVDDEEDDEMDTGMTMEGVGGGNGVGNGVDQQGSTVTPPKTLARRNRLRKNVVKEKVSTGCGPSPPREIVVEAKRATLSDGERSGMKASTGTSPPPQDMSTQTYDTFEQVREEIAALEQTVDKPINNRVEEEPSHQQHQNHDQNIASSLYKRSYSLATPQLLQVDRPASRNSISSDTQSLPPSPHELSPQPGLQSSTRFQANTALNQPSHPNPSTSNTTSSPSSAHYGQQQDETLSYLDRAIHQILQTAANQSRGASGVRPAPVDGSKYRTVGDLRRIEEQQQIPVTVAQTQPKKPMVTRERDSMDDHVEPEEIEQQGQPGSLVQNGTGKEEPSEMTLLLREAERYQFTAEELQAALNHCGDKHPVQWLRGNWNKLIETVQTLATKYGHEKRENTIGTISTTEAREALRQHRGNIWRAITECIEQRQRKYREIAKQGNFTPXXXXXXXPFGVLITDRFPHAGVAMPPPRSRADSRSRAASPALSVKSRKSTMSMRNLNRNSFVDDLTDDEDSDDEFHRSRGRGSDRRRRERLNSTSSIDFDEPEPANHAFVRASSVKHSRFNRDRRGGGSSARSLIDYPVSRKPAAASRYEREEFGARERFDKMALASPSRKAPSDSYTNESDVEPEGTRRGPSTAAGRTRSSNDGFSSPRKVTSDSLTNDSDADFERRRQAKLRAAQNNLSASARRPTSDSLTNDSEPDHERRRLAGKANKQPSAAPAKKQSSDSDGRDRQRKISSDSKASGGAGGKVSTAGPVPKKIPSDSHTPDTDGEQKRRFATKQQRQRKHSSTEFIANDSEEQEEQTRGKGNAGKARAPAEKPPQQQVVNGLLEFRTISPTKSDSDEQRDAARGGELRTGGLPPPPAPVXXXXXXXLGPPERGRQRQRQLTAAPAGPQRGSEWNHDIQQFISAHVEKELLGEDGCAIQETVPEESPVIADETAEKLQEPEEQTEPEIATLTSTQDAGNREEVCEEVTSNSCNTEILKDIEALIQQMERNQESMNAPVLRNIQQLLTQLVQAEPEPEQSSRSPSVTSVRSQASDQRIMSKSPIPVVRPSIIQHQAHPGETDRTIEDDVRDFVEQNIQEILPNLVQQVRQELDAVHGDQWTKPTGTLEDDIRETLMKADYTESDYSNIHFFPFEKSNEPKAVFPERQVSVIDVASKSPVVDAEDEQEYANIQQFLQRAIKNERTTTAFDRYKRRHYQIDSSSDEARQTAESTDYYDLVSINEKLMSLFNKPPVKEQQLEPSSISRPADMQADQMIVVQTVQEQPVIAKVETVEPPKPSNAAPVPVIPVDKIDTPAATPVEITSEKKGMKKRRGSRVPANKNNYLSRRPVRSSSESDFEGVAHTPKSSNLPTAVAIDNVEALRHVVEKIELIERTVEAENTVNQEVGSAPDQQVEEPIYINLPVNQEPVVFEEPREVKLEPMPAQASQIEEVVLSQAQQEPEPIPVQSTEIKELASTHAAQEPEPIPVQSAQQEEMVLPHVSKEPEPMPAQSAQLNSVVPQVSEESGPDGKALVSNESPLDPKIEGTEAEQETVPSSNPTEADAEKHIVPTRNQTDPKETVQPPAATSSESAIENIAPIESLPAGNGEPSPKEPANVVGNGEVPQDEVLVHSAKLSNNLSELVLDTKRLIQQMKDEINSDIATFNEDDAAYEDDYYEDEYEDEWEGEEEEEEEEWDSNEEYDVDENGEFIDDFNDALSVIEHSVSEMRNMLQLTEEALGPLPDLGGPLQHASSVETLQNSPEQSEISEITLVPEQGILASAAAEESSEQTLVAEENLPMTMKEVQTLMNAKAVIGGFLKNVLNENIEQTVVPVPEPVELPEADAPAVIYDSVRTTSTETTENKPASVIERNSMVNTGPAETPAQIISPNDVNGLGTHGTLLNENNVQSEPQPNEPVQIATGNAVLQNTEVLTPVQDLEPSQLELAENITQGPLHPTSEDRQSDSTIQKPVMNGVPTSGTDTLVVDEKIVPTVAHNVGGEDGIQESGIQNQAVTLPQEMEPVENVTPEYVNVAALQAIDTLEPASTVPDYATVIKTGSQLHVIENVVNGAQSELNGHYDEATTSAGSIPVVSNDAQLVESPSSIAVSKDDENVPKLDTVADGTSNSTIDRSSLTQSGEAPDQQIQAAEKLDANVNVGQTPNITDDASTANGASSLPSHVESEPLTSTESTASVKEDSVIEQQQPANDVRTTDHASKPPSSITQNGIASAALTQTPDTTYDRPPSPASSEEPSSSFIEVQPSQVIVHSPHPTSPPEAPPRTTNIYQNVDIQPPVSTTNGPTTVRKKASSKLTVKITNATTLQSDDGTSPTTPPTPTASKANAKASKTTKSDAKKKSTTTTTTTPTTTADPSGRKQSIVRKKSTGSPFGTVQTNTVKAMQKEFLSKAKESPKPSTSKVTPKPSKLVQPKVFTNVRTSPPSSSSSSIPAAPGTSKASTPASDGASSSRSTPGLMSGAPDEPGPSTSSYTCEKMLKKKYRETCFSDDYQTTDDEDESRMTITESERTIIKSLVKPYEPDSDPPEVQAKKILDDGLVQSLTQAELAVQLIELRYAKDSAIWAATQCHTIDEAKDLLQKECELCLGVFPMNEIVSMLKCTHTCCLECAKEYFTQEITNRSITNCNCPYCKEPNLNGSDVTEDDVLEYFSNLDILLKSIVDEEVHDLFQRKIRDRTLTQDPNFKWCVHCSSGFFARPKQRRLTCPDCGSITCASCRKPWESQHEGLTCEKYAEWKEANDPELQAEGVQRHLQTHGISCPNCKFRYSLARGGCMHFTCTQCKFEFCYGCNKPFMMGAKCSVSPYCAKLGLHAHHPRNCLFYLRDKEPRDLQNLLLMNNVPFDTEPSEMMKQEHMNGQSTIPKCPIPLQKETPAGLMDMICSAEVPEKHAGLCRTHYVEYLVSTVSKAQIDPLPILDLTDCVQELRRRGIPLPERGPWDTDVIYREMCQKIVKEQIPLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI94</accession>
    <name>A0A084VI94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP012343-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00004937</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013334">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524853">
        <property type="protein sequence ID" value="KFB37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VI94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004937-RA">
        <property type="protein sequence ID" value="ASIC004937-PA"/>
        <property type="gene ID" value="ASIC004937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004937"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019473"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024512"/>
    <dbReference type="OMA" id="PSCTISW"/>
    <dbReference type="OrthoDB" id="6106100at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF32">
        <property type="entry name" value="NEUROMUSCULIN, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="246"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="358"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="455"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="564"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="653"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="771"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="856"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1423"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1362"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1432"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004937-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1547" mass="170893" checksum="1676AFF64EB0869A" modified="2014-10-29" version="1">MPVAVIAPLGADLGRLLKDQLKVAPVDETISVLRGEKVELACPIDIATCGELHSLKWFKGTERIAVVSGDGEVAKVEGSYNDRLSLSHETQTSRLIFRSVEIADEDTYLCETTFLEPSEQCENTGAYSVALNVYAVPSVITLQDGNRNSIKNGSHIGPMREGQDLQVVCEVYGARPEPVITWHRQGRVVRDNLAVEEHDGLYTVKSTMSLTLSRQELGATYNCKVEMKELHLTVENQFHIDLQVRPTKINLSGVEHHTVQGTKVLLQCKVSGARPAANMTWYNSSKLITEESGEMTSINTKTYLQNDGTFETISQLIFTATRFENGASIRCEADNVVMREDMDRPLHDTLPLEVMYPPVVSVKPENITVNETQDFLIFCDYEANPASLENVKWYRDNQEIKLNSVRYEGGNPEQTALLIKNSTRHDIGAYTCELSNSIGFDVSDNEIYVDVIYKPTVTLTMDPEVPVIENDQANVTLLCNIVEGNPMLLTRVRWLLDGDFLKELPECDVETLGTDANLCEVDPSKLLLQNVGRDFIGNYSCEGFNAAGWGDVSEDNPLDIYYEPGNASMVHFPTIAIKRRSVTFNCSIEDRGNPVATRYRWLRGGKAVLDVVTPSWTVDPVGLDSRTTFSCFAYNEGGEGNAAEVDLEVHAPPAFIQKLQPYTGALFSTTNMSLSCRVECVPSCTISWFKDGIGIEESDERYYITNSYLPSEPATGDFESAYSVLHFNMSAWANGILDRIKDSSNYSCVSTNNSAGPGVRSTTYFGVEYPPENTSLSSTTISVEEGKIPPKIVCSSRAYPEPAFIWTRNGETIAKGSALIVDDVLQRSDAGKYTCTAFNKHGNHSTDAFIDIHYKPTCQIIRKEVEDEEVLICVATGSPRESEFEWSVKYANDSIQSNRIKSDAYESYLTLDDGVSSMRIYVCVASNNVGMGTPCEIEVAGYVAWWLKGDVLTPYILIGAVAALLLAVILVCIIIICICRRKRRQEKFTGESSTAGGSQIEPGEYENLPFHGLQTPPKKAMLCKTNLGPSLKHHNKTLTPSCFPTHPYNYINYQKDSQKGLQAPLHPTLQHPPGMHAPSGGDDSSKSAERKLASSLMDNNDDTLSSHSFTIGNTGSGRSMKQRASAEKNHLIDLDTVTPLYENLTDSIQIHEATPESSVPTAHSATLGPGGLLPGKPLILEGPHQERYRISLKKPGRKGHSGNASRSNSAVSNSYYDCIKPIPAPRHRKYASTNSLVSKAMSSGSSSGSGSGNGAMSHHRQQHGALQPYGSGRLDPIYMNLPLGKGLESSSLRLQHSDSDGGGGSYPTMPHDNHYLEITQHQTRIVIPRELFPVDSREQQAKLSQLLRKSVAPAVPPHPNHHPSSSSSSSINSGTTTSNNNTSSSSRRHIKLPLQKHHSFNFQSSQTVEATVRDLKIKSHSISSKTLRDYRGNNSNSNPHRSSSHSNGPSSHHQHSPHGTSGTLQEHDDSENEYYQDQEQQQHQQQHPQEPQQRHHRAAHFPYDTSTDGIAYPEDVIYADLEENNYGPINYKAASIYNMMKFKRNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIH4</accession>
    <name>A0A084VIH4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP011433-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00005084</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIH4"/>
    <dbReference type="STRING" id="74873.A0A084VIH4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005084-RA">
        <property type="protein sequence ID" value="ASIC005084-PA"/>
        <property type="gene ID" value="ASIC005084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005084"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010466"/>
    <dbReference type="OMA" id="NCEMECH"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005084-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="461" mass="52635" checksum="C0C3E9560BBD448F" modified="2014-10-29" version="1">MEPMDKVILQQREVPCNKVPQPPLQVAGEGDEGILKDYLHNSSFPVARYVLGSDLRHSLRLFWVAVGLCLVAVFSFTVTVCIERLKDPSNVFVGEAERPLPIWSIPFPALTLCPTKKQTCTGENIRLEQLCEKICWEDNCTQCAKLLDPVRTDRGLCYTFNAVAGNEIFNNVSITNVRHLSNVTRLTENWDFLRGLQLIHKVQVKEYPRAAQDISGRYRLRIFTLRELNESSCPTPSLDAYIHSPIDFPFKPNKPTPIPAEQGLVLLTVYPKLVRSQRYLRYFTSSATGCISQLQNPLKYFTIYTQANCEMECHTNFFLQMRRCVLDHMPRAPNTSLCNGTSKYFNVYNKNTNALLRAEKIPRSHFFRWKCNCLPACVEFRYSAEVSQDLVSPSNDSEPTSTQLVVEFAEDHFYPLVRVVRYGWIDFLANFGGLIALFLGVSIVSLLEVFFFCLVKPAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIP3</accession>
    <name>A0A084VIP3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein translocase subunit secA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005008</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013377">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIP3"/>
    <dbReference type="STRING" id="74873.A0A084VIP3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005008-RA">
        <property type="protein sequence ID" value="ASIC005008-PA"/>
        <property type="gene ID" value="ASIC005008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005008"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015202"/>
    <dbReference type="OrthoDB" id="7663308at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005008-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18578" checksum="4239DB7E4C98FDED" modified="2014-10-29" version="1">MEENVVLAVRADMLGEDGKAGVAGIYGDYGKNGWDMGYADYSVSRVFTEPWPKYYGLDGNSKLTLDYQTEQSSSNVYCPYKDSIDHNQIYATIKQSAIDIKRQTKYTGHEKARDNSDRKHYALATRKNTILERTIRDTYADYLFMDKMNSDRKKALHLMQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIT4</accession>
    <name>A0A084VIT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Serine/threonine-protein kinase AtPK2/AtPK19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005195</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013400">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005195-RA">
        <property type="protein sequence ID" value="ASIC005195-PA"/>
        <property type="gene ID" value="ASIC005195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005195"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005195-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="132" mass="15250" checksum="F3E1A3450E370707" modified="2014-10-29" version="1">MVSRICSEVLSNWSPVMCSEVLSMWIPVMWGRHCRVRHQDRWTKSRLYFVPASSCRHDARPFHLEAMQLESNRSQSIQLDRPSIASLCPVHVSRPESLPRCASKHEESETERRPARCEAKREKQPIPGLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ66</accession>
    <name>A0A084VJ66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005274</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013468">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524859">
        <property type="protein sequence ID" value="KFB38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005274-RA">
        <property type="protein sequence ID" value="ASIC005274-PA"/>
        <property type="gene ID" value="ASIC005274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005274"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005274-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6734" checksum="365D7143BDA5504A" modified="2014-10-29" version="1">MLDANVCTRLATKAIDVCARTSSKPRDKSIPVECCTAEGAAGIWWARSGLKDGPAQCSPGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJX2</accession>
    <name>A0A084VJX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005587</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC005587-PA"/>
        <property type="gene ID" value="ASIC005587"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS018007"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="187"/>
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        </location>
    </feature>
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            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005587-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="305" mass="33178" checksum="50AC9BD683589BA5" modified="2014-10-29" version="1">MENQWASHNNANPKSSASSSTPPSSDAPLTPAVQSHSSSASRSRCHPVICDVMRLETIRERNSVYSEDGEFIDLPLPPVPQSSNTATDSTVSDCVGRDREHEQQMPAVKNRADAYLQSRLQDFEEEDGPIGNGYIGEGDCVEEIILAPLAMDNNINFRSTLHGRAVDEEIKSIDSSTSNTLRKSAWSVVSTGSTGGGCSSDDFSEGDDSEGEDGNQAEEDDYGERSSGYRDKSPFLRSVSLSPVERRFRKQSVPARQRRRKSASSAGKHSSESGGNWSHQRADVHDAGIKTNTWGTGIAEETINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJZ9</accession>
    <name>A0A084VJZ9_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Solute carrier family 15 member 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00005636</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005636-RA">
        <property type="protein sequence ID" value="ASIC005636-PA"/>
        <property type="gene ID" value="ASIC005636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005636"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005636-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18632" checksum="44B16D10834341BB" modified="2014-10-29" version="1">MFGNNKNHLQKETIHPTNRQIEPPSAHSEKIKRKRIVERGGETNEIRFRCARPPERILPLSRGRKTEIPTAQQAAGRAEFEFECRVRDGKGEDQRHGVSGHGLTVVEKRSRTYRYRMGEFWGGIEGDRFLFSAKVKTRSELKQPSLNKEDTGNILCLFAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK41</accession>
    <name>A0A084VK41_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP009958-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00005725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014107">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK41"/>
    <dbReference type="STRING" id="74873.A0A084VK41"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005725-RA">
        <property type="protein sequence ID" value="ASIC005725-PA"/>
        <property type="gene ID" value="ASIC005725"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005725"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021781"/>
    <dbReference type="OMA" id="VNSHGRH"/>
    <dbReference type="OrthoDB" id="5862042at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033371">
        <property type="entry name" value="ARGLU1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31711">
        <property type="entry name" value="ARGININE AND GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31711:SF1">
        <property type="entry name" value="ARGININE AND GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15346">
        <property type="entry name" value="ARGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005725-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="31098" checksum="302A49871767DCE6" modified="2014-10-29" version="1">MGRSRSRSRSPKKHKSKHRKRSKSRSSSHSKHDHHHRSSYDKYRDRSSKSRKRSPSASSDSSSDGSHSGSRHHRHHHKKSSRSRKLTEVERLAEMERQRRQKEAEQKMIEEEAAKRIELLVKKRVEEELEKRKDEIEMEVQRRVEAAKKQMEQEMMLELEKRREQAREEERRREEEELKKRQELENILAENNRKIEEAQRKLAEDRLAIIEEQRKMDEERQKMRKEQEKRIKEEQKMILGKNNSRPKLSFSLKPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK89</accession>
    <name>A0A084VK89_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011644-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK89"/>
    <dbReference type="STRING" id="74873.A0A084VK89"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005747-RA">
        <property type="protein sequence ID" value="ASIC005747-PA"/>
        <property type="gene ID" value="ASIC005747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005747"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000470"/>
    <dbReference type="OMA" id="EEGPNDW"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000009">
        <property type="entry name" value="inositol polyphosphate 5-phosphatase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005747-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="469" mass="55153" checksum="BB1A95740DA03860" modified="2014-10-29" version="1">MFGRKSSKRRRKSYPVKQAYRTHHSYRIYIVTWNVSTKFPENISLNKLLGLENRPEQDTHLPDFFVVGLQEVNAQPQNTLFNLFKDDLWTQKFKEVLKERDYVVIKTEQMQGLLLSVFARRKHLLHLRQVETEYTRTGLGGIWGNKGAVSIRLNVYGSSICLVNAHLAAHDHMLEERINDYERIVQEQKFHIKAKETIFDHDYVFWFGDLNFRLTGEATTSADEIRAMVARDELKQLIEKDQLLLVRREGRAFQKLQERLPQFPPTFKFEHGTSEYDMKRRPAWTDRILYAVNENNYRNVRLTVEQTSYKSHPSYSISDHKPVTSEFTLKVYEDTTERTITFRPIDLWLVGEPNTIEYVIPTGFEESNADWIGIYRENFTSLSEYLAYEYTETYKDKQHQLNEQQIQHLQNTRTVQLTFSENVSLPLGERYQLLYFQSTGTRGVTGLVGISEPFAVEKRCPSPSFDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKJ6</accession>
    <name>A0A084VKJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005895</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014227">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005895-RA">
        <property type="protein sequence ID" value="ASIC005895-PA"/>
        <property type="gene ID" value="ASIC005895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005895"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005895-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13762" checksum="A7701939B3AD8908" modified="2014-10-29" version="1">MRRDVCLSQAHSFYAPLPSLAPSPCERVSPMCTRHQRQHHFGNRFSTIVHNRTDNVREDREWIAVGRGSELCSATVNVLRYRTSSRNGCCEWGGVPMGGGGRRDDGDEDLVAAAGYCLTLPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMT9</accession>
    <name>A0A084VMT9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras suppressor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006635</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014627">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMT9"/>
    <dbReference type="STRING" id="74873.A0A084VMT9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006635-RA">
        <property type="protein sequence ID" value="ASIC006635-PA"/>
        <property type="gene ID" value="ASIC006635"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006635"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011563"/>
    <dbReference type="OMA" id="RHMQGGR"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000159">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="7">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006635-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="274" mass="31131" checksum="243CB43BC5166954" modified="2014-10-29" version="1">MSKAKKVLDEARENKNREIDLVDRNISTFDELPGLLNMVFVTRITLSHNKLKIVPPGIANLINLEILNLSNNHLEELPLSLSSMPKLRILNCSINRLNTLPRGFGAFPVLEVLDLSYNNLNENVLPGNFFMMDSLRALYLGDNEFEYLPKEIKNLKNLQILGLRDNDLLELPREIGELTRIRELHIQNNRLSVLPPEIANLDMPGPKSVLKMEENPWVTAIAEQYLVGISHVLEYIKTEAYRILYNRHTQSGGKTSGDLPPKSDKSKKASRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPL5</accession>
    <name>A0A084VPL5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007288</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015011">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPL5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007288-RA">
        <property type="protein sequence ID" value="ASIC007288-PA"/>
        <property type="gene ID" value="ASIC007288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007288"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007288-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10702" checksum="CFCD00F4E5976A97" modified="2014-10-29" version="1">MRTVGGVENIKWEHNSMEDDDDDDDSQMGNSTLAQWPVDCSNILFLGMIGIPDAKSTNTYKGNGQIRLLVSDCYWINASAKRGRSKEGVAGLYWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQ83</accession>
    <name>A0A084VQ83_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">L-ascorbate oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007662</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQ83"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007662-RA">
        <property type="protein sequence ID" value="ASIC007662-PA"/>
        <property type="gene ID" value="ASIC007662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007662"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007662-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="7892" checksum="1D494848E0FBB517" modified="2014-10-29" version="1">MAEGLQPVKVCRVTPTPALRPAVVTLDASVCGRAPKAANRRRPPPCRVLCCFLPGDHLRKLHIAALTQLPANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQA1</accession>
    <name>A0A084VQA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP000641-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007681</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC007681-RA">
        <property type="protein sequence ID" value="ASIC007681-PA"/>
        <property type="gene ID" value="ASIC007681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007681"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017001"/>
    <dbReference type="OrthoDB" id="5978988at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF46">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 99A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783904" evidence="6">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="230" mass="25919" checksum="B662011899E4381B" modified="2014-10-29" version="1">MNSFVISALVLAAGVIVASDALQHYAVEKSFSEAQAECAVYQGVRDDDLLRYVKEGYPDXXXXXXXCYYQHYGALSECPQFVVNTYLEDLQQSYDLFGMLDVSRPTLQSLAGGCFPSGEESLCFFRNFVTRSKLYTDEDGYNLEYLYYQYQEEAFNPNNALTVACLANQKKLACKKSKCQHAYDSFQACFGETKAREYLVLTVFADAAKNVLAQPVCNCTKFKVCDLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQW4</accession>
    <name>A0A084VQW4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00007740</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015335">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQW4"/>
    <dbReference type="STRING" id="74873.A0A084VQW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007740-RA">
        <property type="protein sequence ID" value="ASIC007740-PA"/>
        <property type="gene ID" value="ASIC007740"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007740"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007518"/>
    <dbReference type="OMA" id="HAVNFDI"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783992" evidence="3">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007740-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="18825" checksum="B96529C124D2CEDA" modified="2014-10-29" version="1">MVLLLHRAILFVPGAEVTAEPTVGNPFTNPFTRAYDDSLLCVKDMGCLGSKDRLSKEDMDFLKSHTRYDESTIKEWYKGFKQDCPNGKLTPAKFVDMYKMFFPSGNAEEFCDHVFRTFDMDKNGYIDFKERLTLAPALAIGDTTAEGGCNNMAITQPIAEVTTLLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRD0</accession>
    <name>A0A084VRD0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRD0"/>
    <dbReference type="STRING" id="74873.A0A084VRD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008018-RA">
        <property type="protein sequence ID" value="ASIC008018-PA"/>
        <property type="gene ID" value="ASIC008018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008018"/>
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    <dbReference type="OrthoDB" id="418445at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="KH_dom-like_a/b"/>
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        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
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        <property type="entry name" value="RBFA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008018-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28865" checksum="A1D9F6BC2F033ECC" modified="2014-10-29" version="1">MVRYKRNRCAVRSSTKAAKVLNKLMSGSNKAKKKRYYDETNDRTPKLMPATSLASTNRQGKESSRRVAVLNKLFMKNITDLMATGSFASDLYGYGIQISRVRVAPDFREASIYWFSSSLNKDVKIDIILKQLSYRLRHELSQLRVMGEVPVLMFVQDKRYYVEGVLNALLKEADYGEDGEEVSDPTGTVVEERIREPEMRHDILGLDHSQIMNRIRQSVDKTNKAWKMHQEAQRKHSSAVDSRKKDANQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRH5</accession>
    <name>A0A084VRH5_ANOSI</name>
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        <submittedName>
            <fullName evidence="7">AGAP004480-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00008068</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525026">
        <property type="protein sequence ID" value="KFB40569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRH5"/>
    <dbReference type="STRING" id="74873.A0A084VRH5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008068-RA">
        <property type="protein sequence ID" value="ASIC008068-PA"/>
        <property type="gene ID" value="ASIC008068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008068"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020333"/>
    <dbReference type="OMA" id="NAVRNKD"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="78"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
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        </location>
    </feature>
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            <begin position="156"/>
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        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="358" mass="39940" checksum="BBF2B98F8F97ED90" modified="2014-10-29" version="1">MEPPTRIKQEPGIKTDYMVNTSSIIPNAAGSMDVAVKTERLQSFRMPRDLTLTNGRATKPPANKKVYTPNLNAVRNKNTDVKTASTGAKSRVKTDRNKNDKDLKNRKASLIQTSGIFSDGLAQRAPTRASKYDRSGSSKEPGESIRKPVFAKTESKIDWEDERKRLKHLYDDEEDEVADIDRKMEIGLKLPVKLESDDYKAKPEVKTEIIDDARLDPFSLAESLVSNPEANNIFLLQLPDALPGKCDSGEKQTVNGHEIKTEAPQAATTEETPQYCTVRDLDEGCVGKIIRYRSGKVKLMLGKIMFDISLGMDTGFLQELVSINVNQTERSGNIINISTIKAKLNASPDWEYLFKNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSN3</accession>
    <name>A0A084VSN3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010012-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSN3"/>
    <dbReference type="STRING" id="74873.A0A084VSN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008536-RA">
        <property type="protein sequence ID" value="ASIC008536-PA"/>
        <property type="gene ID" value="ASIC008536"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008536"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002871"/>
    <dbReference type="OMA" id="QPYKKPN"/>
    <dbReference type="OrthoDB" id="6149831at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21205">
        <property type="entry name" value="CH_LRCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000081">
        <property type="entry name" value="Leucine-rich-repeats and calponin homology domain protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="739"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="869"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="869"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008536-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="915" mass="97025" checksum="7F1B34FE6A0B5291" modified="2014-10-29" version="1">MAVAACLKASQSVAVGYAGQTQLGGGMNGIGGGVGGHLQSQLTRSLERILEDAHLSGELKLSGRKLKDFPKAAGKYNLSDTVIADLSRNRFCELPDDITCLAFLERLLVYHNTIRSVPETIRGLHSLTYLDLRNNQLSALPREICTLPLQVLLVSNNRLATLPDELGRMDKLTELDAACNQITHLPARMGDLRSLRSLNLRSNQLVYLPRDLTCLQLAFLDISSNKIATLPVELRQMSSLVDLELCNNPLTSPPASLCVRGLVHVFKYLETVAAREEKTKTGLDGHATLRRTALAGKHSGNNSLLDTHQRNRRAHVDSGYCTSDGGGFDGKRWMHEEDAQHPTSTPSPKWSPIPLHSGFTTLPRGNGSNHNTASTLPSGGQQVSLAAHSSAGLNDAIAEGAGGVVCWEEEFRKNAAQQEQHPDRKQLNDISPEGDLITPDGTKADDKARALSNYQTYREYKEALRQQRNLDSVYRSKDQPLTPDSGGSATDSPVSNVSPYTKSISSSSVYSSSSQSSPVSPHHAGSVQKIEPNQRNGTTSGGANPLLSPNRNGGQSSAHEDGASGVGGGTPNKRPVQKVIPSRNISSTHQSQQPSPTHLNGNHHPSALGAGSSSAAGSNGTQGKIPLANGSGKTSSLAGGGSRAGSEEYAYVKPNSPCKTTSGILTHNNVPPSSIPKPTAPNGGGLTSPVQAGQKPLTATVGYVNNAKPGQKTNKTVSWNRDVPTEKLSFTMRREFDKQKEETELIEQLRQIIETRLKMSLPEDIAPALMDGVVLCHLANHVRPRSVGSIHVPSSAVPKLTMARCRRNVDYFLDACRRIGVDENLLCCAADVLEGRGTVQVAITVVELLKYHNPTANVRSPTRNLYATGSSSFSSGGSSTGSTGSNGTVAGGPKSSPSSSSLSSSVGGGGGANGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUB9</accession>
    <name>A0A084VUB9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00009163</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="EMBL" id="ATLV01016715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUB9"/>
    <dbReference type="STRING" id="74873.A0A084VUB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009163-RA">
        <property type="protein sequence ID" value="ASIC009163-PA"/>
        <property type="gene ID" value="ASIC009163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009163"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001462"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022053"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF145">
        <property type="entry name" value="FI17609P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783889" description="CLIP domain-containing serine protease" evidence="12">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="14">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="116"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="390" mass="44205" checksum="A9FD6D6688823358" modified="2014-10-29" version="1">MTLQEKCTVLLLIATGYSVVSQSYPACITPTEKNGFCVPIERCQNIYNIENYSTSPPSQGIRNYIKKAACSLPEARRSVCCQPEEILPRSTRKLIQRNSNLLPTDTCGKIAWVDRIALGTKTFPFQYPWMVMLWYKLNDTWLIDDCGGSLINNRYVLTAGHCVKTKSSVKLVKLRLGEYDKSTARSCFVNMEGDEHCAESYDVDIEETIVHEDFGQPKYRHDIALIRMAKKIIFSELDPACVTPTKKNGFCVPIERCRNIYNYLKGITGTQNRAHLNYIKRAACTLPDVERSICCRPEEILPRPIRQFKLGHEPTPGAQLNWDLLPTDICGTLTTDRSSWAAKTLPFEYPWVVLLRYQTDHGLVDKCGGSLINNRYVLTAAHCTLDSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUK1</accession>
    <name>A0A084VUK1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003762-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CHK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009270</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525127">
        <property type="protein sequence ID" value="KFB41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUK1"/>
    <dbReference type="STRING" id="74873.A0A084VUK1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009270-RA">
        <property type="protein sequence ID" value="ASIC009270-PA"/>
        <property type="gene ID" value="ASIC009270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009270"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024397"/>
    <dbReference type="OMA" id="IKFCATC"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF12">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="137"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009270-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="362" mass="42071" checksum="B5D64F05A41600C8" modified="2014-10-29" version="1">MPYNPDELVAPSWLNDEFFRDVMRQVNHDPTIELVSECALRPGTKLGEHYASVMFRTSIKYVSKKSNVEQSINVIMKTTPEADGIKKELLEDNKLFDTEIRMYSKILPEMARLLKGVGEEYKYPRYIYGALKPHSIVILEDISHQGWIMGDFIDTIDEMKPIIKNIAMFHAASVVMESKDSNFSTENYFSMADKLMSFDLLLNKGFDDLKYLTVTYPEFARFAKPLDHFRQDLRKVLESAYKPSRTFQNVLNHGDFQCKNMLHQIDRDGRHTDTILLDYQICCWTSPAIDLYSMFDIITTQELKNTCRNELIYLYHQEYSELLKRLGFEGNIPTLLEIQIELLRAAGLGMRLSKCLKGLQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUN6</accession>
    <name>A0A084VUN6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010466-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00009308</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUN6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009308-RA">
        <property type="protein sequence ID" value="ASIC009308-PA"/>
        <property type="gene ID" value="ASIC009308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009308"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015539"/>
    <dbReference type="OMA" id="YEYECPE"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784057" evidence="6">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="211" mass="22669" checksum="8E73EDF52F535591" modified="2014-10-29" version="1">MISEFSQCSCTVAALPNGLAVALFLLGCASAQTTSTACVGQPQYTFVAHETDCWRYYTCVNEQAFPQECPEPFIFVQATQMCDFGDRNACVNCPATGIQNLPVRGSCTKFIQCIEGTQFPRECPPGTQFDIGTGQCNIASIVGCVDLDCPAVDDPQNPVIKPDPINCRVYFICIGGEGIQQLCPIGTRFNPTLQVCDLEANVVCPATVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVH0</accession>
    <name>A0A084VVH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000743-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009532-RA">
        <property type="protein sequence ID" value="ASIC009532-PA"/>
        <property type="gene ID" value="ASIC009532"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009532"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003518"/>
    <dbReference type="OrthoDB" id="7739595at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009532-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="199" mass="21381" checksum="9123DDCAFA52132E" modified="2014-10-29" version="1">MLQLAFRSFFFIAVILGYSTGIWRLINDYFRHEFQSYLEQESQTNKYLLRDPPGAGAKVVLPGGPTFPAGATEGEASRPPEAATAHRTVTDSISEFSNPIAGGTDFLPSPVVAGKKEAGKETTGKMATEAAEVTDIRRGNGEEEGTAEEDKWIAYWQHRGKGSKGGAVGSEAFCSIGRNPSGPPETSMEEETEECAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW12</accession>
    <name>A0A084VW12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009820</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525164">
        <property type="protein sequence ID" value="KFB42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009820-RA">
        <property type="protein sequence ID" value="ASIC009820-PA"/>
        <property type="gene ID" value="ASIC009820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009820"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="234" mass="26382" checksum="87E2632C3ED2C96B" modified="2014-10-29" version="1">MGAESACRTVWRSTVDRLIRLSIDNRQLADVPHSRPVLTCIIVAAIFLPPFFLHLGGPKDDRLGDWPSKKCNCFGRRRIAARSMIYLPAHRRGGRKMTISSGLKLSDWQLADGDITRQYDSYPPLFFRLLSANDRFVNVAACSSDRVRRLYRAPTLSFKSSRIGLSRAQCFDPWQYVCVYVCVTLFPLDHDFDRYRDQLSVIDFSCLLSRCVPSRISFLSGSLAGQTGGSACST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW24</accession>
    <name>A0A084VW24_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP013186-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525167">
        <property type="protein sequence ID" value="KFB42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW24"/>
    <dbReference type="STRING" id="74873.A0A084VW24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009847-RA">
        <property type="protein sequence ID" value="ASIC009847-PA"/>
        <property type="gene ID" value="ASIC009847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009847"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010294"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF397">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009847-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="18202" checksum="4FF8949EEDF5DFE8" modified="2014-10-29" version="1">MPTDLQTGEFQQNRIRLVHTNSSLPYTVTYLDLMYNSIADISNFSALTNLQTLNLEGNYIEKVNGTIFAGMHNLSVLYLEANDILDLDFKGFPKGLTKLWLFKNYLTDLELDDVSMPALTVLDLRRNSLTTIDSAAVFAAFPGLKILPIAYNQFQETRPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWK0</accession>
    <name>A0A084VWK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00010037</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="ATLV01017623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525179">
        <property type="protein sequence ID" value="KFB42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWK0"/>
    <dbReference type="STRING" id="74873.A0A084VWK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010037-RA">
        <property type="protein sequence ID" value="ASIC010037-PA"/>
        <property type="gene ID" value="ASIC010037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007183"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="247" mass="26342" checksum="B2CB888F6AD65A11" modified="2014-10-29" version="1">MGRKFCVGGNWKMNGDKASITELCKTLSTGPLDSNTEVVVGCPAPYLTLARSLLPETIGVAAQNCYKVPKGAFTGEISPAMLKDLGLGWVILGHSERRAIFGETDELIAEKVAHALAEGLKVIACIGETLQEREAGQTEAVCFRQTKAIAAQVKDWSNVVIAYEPVWAIGTGKTATPEQAQEVHAALRKWFTENVSADVSNAIRIQYGGSVTAANAKELAAKPDIDGFLVGGASLKPEFIQIVNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWQ4</accession>
    <name>A0A084VWQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010092</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017707">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010092-RA">
        <property type="protein sequence ID" value="ASIC010092-PA"/>
        <property type="gene ID" value="ASIC010092"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010092"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010092-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="15749" checksum="D733FAA655AD6832" modified="2014-10-29" version="1">MISITITNVLPISTATRLARILTLKSTIPSAPYGSNARSGKGEMVRYFKNVSLPQQWDVVDAYNRLGRSDSSNFPICTDLNKNPCQTNCVDRNGQRVLRVGDRGWLLLLEVKLECFSAVAKNGHGFAGRCRQPPSSSGRYDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXV0</accession>
    <name>A0A084VXV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010543</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010543-RA">
        <property type="protein sequence ID" value="ASIC010543-PA"/>
        <property type="gene ID" value="ASIC010543"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010543"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010543-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6941" checksum="0CA49B6B78AECF59" modified="2014-10-29" version="1">MSDPKPRRTSSGVRCRRLPTGGGLLLWLGLWLTMFVKGREVEQRAKASGCSEARYLDSQMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXX7</accession>
    <name>A0A084VXX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP013234-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525224">
        <property type="protein sequence ID" value="KFB42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXX7"/>
    <dbReference type="STRING" id="74873.A0A084VXX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010573-RA">
        <property type="protein sequence ID" value="ASIC010573-PA"/>
        <property type="gene ID" value="ASIC010573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010573"/>
    <dbReference type="OrthoDB" id="7744861at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784001" evidence="2">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010573-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="19822" checksum="3958D381D8F588FC" modified="2014-10-29" version="1">MKVTFLLELLLILIIIAFAASKPVNDEGRNAHKGTLISRQAAEEVAAPVDAVAPVAPVAPVAGAVQAVAQPVAQAAAAPVVQAAAPIAPAAAKKTKKKVPAQNTQALLDLADAAAAQNEVDSPVKKPEAELDVNSEVNKIAESLTNAGADSAASATDATVDDNEEEEEEYEDTPEKQQQQQQQKPPTKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY87</accession>
    <name>A0A084VY87_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010799</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY87"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010799-RA">
        <property type="protein sequence ID" value="ASIC010799-PA"/>
        <property type="gene ID" value="ASIC010799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010799"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="14787" checksum="E58B2CC67B90A66D" modified="2014-10-29" version="1">MKTQSVSALTGFCCSTGADPVHGASINYPTCLVFLSEHVLPHSDKRQHTHTRGSTGEYQDSGGIEWPRVETLLITVVGNDYTCFQISVSLATCHPSGGRGPNDDALQEKESVLECTSPSELHPKNRSADRFSTAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYF9</accession>
    <name>A0A084VYF9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008839-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00010674</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYF9"/>
    <dbReference type="STRING" id="74873.A0A084VYF9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010674-RA">
        <property type="protein sequence ID" value="ASIC010674-PA"/>
        <property type="gene ID" value="ASIC010674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010674"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014752"/>
    <dbReference type="OMA" id="RFKCETG"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010674-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="653" mass="74845" checksum="9A793DE818F8381E" modified="2014-10-29" version="1">MEIYHKDGTFPRYCEAARKSIDANRFNEFAQLASNEERFRFVNGLQSIVDELHLKREFNGKCMEQAIVFKTLGNKAFQAERWNESLVFYNKCYLSTPKENVQEKSIILANRSAALYHLEKYDLALRDIQRALNHQYPKQMMYKLTERKARCFLAKKDYEAALDSFKATVTALDESTLPLERRQKLERDAQIMINLLPTSIEMEQKTKKKASSKSKAPASQPTKVPEHFIDKALWFDYTQDEGRFARTKSDLKPNTILLLERPHVAALLEDYSLDHCTHCFKRVSVPIACPLCSDVVFCSEECEGKANGSYHRYECGFLPILWGSGASITCHLALRMITQKSGDYFAKIKPELDGLTNEQIDQLPIDDYRKVYKLVTHESERTPEDLFQRTLMATMLNTCLTLGGYSGLNADTQNYLGGLILHNLQLLQFNAHEVSEMIRDREEDVGTSTFIGGGLYPTLALFNHSCDPGVTRYYRGNQVCVRTVKNIPADSMVAENYGPLFTQVRRDERQQTLLQQYRFTCQCEPCLENWPLFSEMDPNVLRFRCDGGKICSNVLNIPAEINDFMVKCTECGEHTNIMKGLKSLQDTDMLFKSATRLHAAGEFEAALLKFVEMMATLSEVLVPPYRDYHLCQQGLRACMLEFGNRYTRAIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZG3</accession>
    <name>A0A084VZG3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Estrogen receptor-related receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00011152</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZG3"/>
    <dbReference type="STRING" id="74873.A0A084VZG3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011152-RA">
        <property type="protein sequence ID" value="ASIC011152-PA"/>
        <property type="gene ID" value="ASIC011152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011152"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023637"/>
    <dbReference type="OMA" id="WNGVRRD"/>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07170">
        <property type="entry name" value="NR_DBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000008">
        <property type="entry name" value="estrogen-related receptor gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024178">
        <property type="entry name" value="Est_rcpt/est-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027289">
        <property type="entry name" value="Oest-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002527">
        <property type="entry name" value="ER-like_NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500939">
        <property type="entry name" value="ERR1-2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="288"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB43357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="520" mass="56862" checksum="CE96801E767A83F3" modified="2014-10-29" version="1">MAGDGTPARIKQELIETSCCSPSPSSAGSNLSQTNNLLYGNSPSGKVTLRSAHSEHGRRRKAFLSHSRAGWQIGSGHSPSNGKPQSPGSPDRQFCSSTTSAIGDFGSDGTNNDTIKEEIPRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPASNDCEINKRRRKACQACRFRKCLLMGMLKEGVRLDRVRGGRQKYRRNPTANPYQMQLVQSNPMYTPQTLEDIKILEVLASFEPDPLSIGNCGDLMNGSTGEERSAGGGTTQSTNAIGTSSSSASSSNSSTTSNSSNSSGASGGTAAADSGVERMAVGGDAQEILSVLSDIYDKELVGVIGWAKQIPGFTDLPLNDQMRLLQVSWAELLTLMLAFRSIPFDGRLYFATDFWLDERSAKECGALDLYNHLAQITQRLEKISATKEEYYLLKALSLSNCDIRLDNYSALKKIRDSILYALNDCVLLLRQHQAVSHQQQLLLLLPSLRQADFIIRKFWTNVHIEGNVTMNKLFVEMLESVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZG4</accession>
    <name>A0A084VZG4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011153</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01018774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC011153-RA">
        <property type="protein sequence ID" value="ASIC011153-PA"/>
        <property type="gene ID" value="ASIC011153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011153"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7297" checksum="A6DE32A1FDA08EAD" modified="2014-10-29" version="1">MYIISHRHQMMQNEPSLIADRKQGSDAIYFKRKGDAHFDGSISSRCSITXXXXXXXFLKFHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0U9</accession>
    <name>A0A084W0U9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011692</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0U9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011692-RA">
        <property type="protein sequence ID" value="ASIC011692-PA"/>
        <property type="gene ID" value="ASIC011692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011692"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011692-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8472" checksum="56B2504FD80AD26F" modified="2014-10-29" version="1">MKITSVRARRTIDGGRDVHKLIRGALILEQASDPISSGSLSFSRPGSGPPECVFVCAWGGLWVYGKCPLPGDGGNETVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1U0</accession>
    <name>A0A084W1U0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012063</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525272">
        <property type="protein sequence ID" value="KFB44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1U0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012063-RA">
        <property type="protein sequence ID" value="ASIC012063-PA"/>
        <property type="gene ID" value="ASIC012063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="191" mass="21067" checksum="E2BB83BFDE5A2E44" modified="2014-10-29" version="1">MGHPRTLSALPPTPPPPPTQLATTIDYDNRHQYRDHRMQQNHHQPTAYSYTTSLLEMLLLSTMLSPMAGALWTSEAQFSSAILFSTPPSTIGKSSSSVALTAHRRMQPPVENVDAAGNRWSVKHKSLPTSRRFPVDGESKTIGKFNFTSRTATTPTVSERRTHRITSSSVAASFTAGARLESHLPFNEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2A9</accession>
    <name>A0A084W2A9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012292</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2A9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012292-RA">
        <property type="protein sequence ID" value="ASIC012292-PA"/>
        <property type="gene ID" value="ASIC012292"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012292"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012292-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7840" checksum="928E2BE1C2C217DE" modified="2014-10-29" version="1">MGRNRRLKTNAVTGGGVIRIIVITGTIIRYLFFTGAGHFADSRVQTQRRALDKPQPVVDMLNPRALGYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2G6</accession>
    <name>A0A084W2G6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012356</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2G6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012356-RA">
        <property type="protein sequence ID" value="ASIC012356-PA"/>
        <property type="gene ID" value="ASIC012356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012356"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012356-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12160" checksum="2AD9E89555277AEB" modified="2014-10-29" version="1">MGSFCPDGRKAPLSGNKKERAVYLQAVATHPPPGHKIIDHRRGRGLERAPVGNLRFGSGKQSANLSKPRHRSGQILTRAGIDCALLQRCSRSVEVTHVTRHGVDTTNRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2Z2</accession>
    <name>A0A084W2Z2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012469</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2Z2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012469-RA">
        <property type="protein sequence ID" value="ASIC012469-PA"/>
        <property type="gene ID" value="ASIC012469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012469"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11525" checksum="7C8898DFCFA6A0F0" modified="2014-10-29" version="1">MNMFIRCIRAGSDEAHLISRSADGSAVLLWRHIESIKRSAKRSTHLFADQQPARFAGTRSKALQAVPRKFLSCRRPRPGPGSSPALPAIRFNVFGSPAVVERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M1</accession>
    <name>A0A084W4M1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013123-RA">
        <property type="protein sequence ID" value="ASIC013123-PA"/>
        <property type="gene ID" value="ASIC013123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013123"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="241" mass="27358" checksum="AE4859C02EEA0D15" modified="2014-10-29" version="1">MQCYRLHRPQRLLSLDHDDQGRVHLSEAHDRAALTSSALTGGSRRRRRRSAISDQRRYARARLKTGPVRRPRRDDAMCARFRAKQEEDEQQQSKMLRQARRHRTVEQWAVGGPGPLRRAVVSGCLRRRRRRPKSEQNEPNRSPNRAGSGGELCALYASEPDEVSESEAFATPRLVSRGTGEGRRRSDTDSSVIEDPLTGSLTSQHGFPFPSSYDRPLMLSLSAVTLTFNFISSRTVPHRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4T5</accession>
    <name>A0A084W4T5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013065</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4T5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013065-RA">
        <property type="protein sequence ID" value="ASIC013065-PA"/>
        <property type="gene ID" value="ASIC013065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013065"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008864"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013065-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="169" mass="18914" checksum="4F2978DEFD37C63C" modified="2014-10-29" version="1">MVENVRKTPSISGVSFFRFAVFASLSPPSGEEDVRSQEFISCPEPGITPSARLFPLQTGDGLAMTLILHHSWLLLLMMIMMLMSDEGVRCYTLDYGLRYCWDLELGCVAHVTSHTEAEIQRAKTVDRLWLLYDDDWTILAILSEVASRPGDYFGPSDNDGMHRSLAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4T8</accession>
    <name>A0A084W4T8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nitric oxide synthase</fullName>
            <ecNumber evidence="5">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00013068</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01020382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A084W4T8"/>
    <dbReference type="STRING" id="74873.A0A084W4T8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013068-RA">
        <property type="protein sequence ID" value="ASIC013068-PA"/>
        <property type="gene ID" value="ASIC013068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013068"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004482"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006090"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015627"/>
    <dbReference type="OMA" id="QVFDCRQ"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000033">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="677"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="928"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1545" mass="172996" checksum="C85C878DB96152FA" modified="2014-10-29" version="1">MSQHLSSMLEHLKMGSLMSKGGGGAGGAKQQQVQPVSAGSTSSPNVAVVGNGSIAGAPNGCANNNVHCSSGAPLSNHQNNNLHHHNHNNNCQNGGAGMTGAKIGADTPVIVERGRCTTTVVEVSGKSANHVGEDRRGYDVSRKRCSISVQQHGVAGGGGSEAGGNSRSNYRELSPASLRIHRKSSHDIRNTLLGPDGEALHLHDPSGKGGDGLGKMPTVVKPIKLKSIITKAESYDTMHGKASDVMSCSREVCMGSVMTPHLIGTESRKPDVVQQHAKDFLDQYYSSIRRLKSPAHESRWQQVQKEVEATGSYHLTETELIYGAKLAWRNSSRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYATNKGNLRSAITIFPQRTDGKHDYRIWNNQIISYAGYKSADGKIIGDPANVEFTDFCVKLGWKSKRTEWDILPLVVSANGHDPDYFDYPPELILEVPLSHPQFKWFAELNLRWYAVPMVSSMLFDCGGIQFTATAFSGWYMSTEIGCRNLCDANRRNLLEPIAIKMGLDTRNPTSLWKDKALVEINIAVLHSYQSRNITIVDHHTASESFMKHFENETKLRNGCPADWIWIVPPMSASVTPVFHQEMAVYYLRPSFEYQESAMKTHIWKKGRDSAKNKKPRRKFNFKQIARAVKFTSKLFGRALSRRIKATVLYATETGRSEQYARQLVELLGHAFNAQIYCMSDYDISSIEHEALLLVVASTFGNGDPPENGELFAQDLYAMKLHESGHHQAHSELTIAASSKSFIKANSRSDLGKFGHLGGRKIDRLDSLRGSTTDTLSEETFGPLSNVRFAVFALGSSAYPNFCAFGKYIDNILGELGGERMMKMATGDEICGQEQAFRKWAPEVFKIACETFCLDPEETLSDAAFALQSELSENTVRYAPVQEHESLDRALSKFHNKKSTECSVKRNPINLHCEMNGTERSTILVEIVAEGIDYEPGDHVGIFPANRKEIVDGIIERLTGVNDPDEMLQLQILKEKQTQNGVYKSWEPHERLPVCSLRTLLTRFLDITTPPTRQLLTYLASCCGDKADEERLLMLANESSVYEDWRYWKLPHLLEVLEEFPSCRPPAAVLVAQLNALQPRFYSISSSPRQYPNEIHLTVAIVTYRAEDGEGAEHYGVCSNYLANLQPEDRIFLFVRSAPSFHMSKDPTKPVILIGPGTGIAPFRSFWQEWDHIKTEMVDSKIPKVWLFFGCRTKNVDLYRDEKAEMVKKGVLDRVFLALSREENIPKTYVQDLALKEAESICQLIMQEKAHIYVCGDVTMAEHVYQTLRKILATRENRTETEMEKYMLTLRDENRYHEDIFGITLRTAEIHNKSRCGLYIAICLTKGIATEHEQETGRCIASLPRKYKPSVHVSYGQLLLTCRICMYGALKFPAIDRHPRPSSEVMVNDHHSNLENGKQHEPQSHVSFDQTCQIDVILRRLGGPIIPILHADAQNAASRSGPPELEMHNGQQIKQVMLPTSFTSRNGNRNDNSACVSLRVSDSLTNTPSGTGEGRYIVKQGKQKTESTVRHLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5D8</accession>
    <name>A0A084W5D8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013463-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013364</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020591">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5D8"/>
    <dbReference type="STRING" id="74873.A0A084W5D8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013364-RA">
        <property type="protein sequence ID" value="ASIC013364-PA"/>
        <property type="gene ID" value="ASIC013364"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013364"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018372"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013364-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12246" checksum="CDED8EF4AB272732" modified="2014-10-29" version="1">MGLFQDRKQAALEKALRVGDLEKFQLAFKNGARADAPVRRSHYTIFETACNTRGRHEFISACFNENLTNPDPRRKNNPVTHEYPIHLAAVPRSTEEVRSCTWDRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5S7</accession>
    <name>A0A084W5S7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dynein assembly factor 3, axonemal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013558</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5S7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013558-RA">
        <property type="protein sequence ID" value="ASIC013558-PA"/>
        <property type="gene ID" value="ASIC013558"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013558"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013558-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="11257" checksum="FDA163ECB3BFD202" modified="2014-10-29" version="1">MVDQSNRFDDNVANSTESTPRHQIGAPGAGSSFRGFGVAFWWIAVKVCRIVFAGDVHAGVRLERHAMLPGGVGSPSELLTAEPTPQPGLSHRRNRGCSGAVPSECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5T2</accession>
    <name>A0A084W5T2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP008347-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00013563</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5T2"/>
    <dbReference type="STRING" id="74873.A0A084W5T2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013563-RA">
        <property type="protein sequence ID" value="ASIC013563-PA"/>
        <property type="gene ID" value="ASIC013563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013563"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008317"/>
    <dbReference type="OMA" id="PPGNCSM"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="578"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1108"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013563-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1160" mass="129454" checksum="3CC8E6D75FD33843" modified="2014-10-29" version="1">MNHCESRTKKGDLSNNNITHLPNKSFDTLPNLEELILSHNKLDQIYSEAFFGLSNLKKIALQNCGLVRVPMEALRRIRTVISLQLDNNLIADMENVTFRGLHLLKSLRLEGNLLQRVPTEALIGLRSLEALNLGNNLLTIIKERDFPVLDNLYMLILRRNQITEITSGALTNLTRLKVLDVDDNSLSSVPVGLENLMMLQEISASGNRIRWISKGDFPKNLVSLELKSNPLAGIKPGALQNMPRLRKLILSDVRGLNELPPLDGCTSLEVLRIDRANLSKIPDHICKTSPRLKSLDLKSNILLSIPNVTNCRDLRLLDLASNRISTLHGAPFSSLGQLHDLLLSNNEIESIPQDAFIGLTRLQVLDLESNRVYFIHPDAFRPMKKLEDLNLGNNLFPQLPTVGLERLLHLKTFNNPNLREFPPPVSFPRIQTLVLSYAYHCCSFLPLTTATPKVPNTFNIRENVLFPTDNEFDMSLWNNSYNDIWPQLQNLSKKFGTQISDLLSAYGAEYGSYPGHIPTFPDEYFEDELGITHASPTAQPGTIQCLPEPGPFLPCQDLFDWWTLRCGVWVVFLLAMLGNGTVVFVLIFSRSKMDVPRFLVCNLAAADFFMGIYLGFLAVVDASTLGEFRMYAIPWQMSAGCKLSGFLAVLSSELSVYTLAVITLERNYAITHAMHLNKRLSLRHASYIMTVGWTFAITMAVLPLLGVSDYRVFAVCLPFEIQKGTGSLAYVVFLMFINGVAFLILMGCYLKMYCAIRGSQAWNSNDSRIAKRMALLVFTDFICWSPIAFFSLTAVFGLHLISLEQAKVFTVFILPLNSCCNPFLYAILTKQFKKDCVLICKAIEESRVTRGIGRCRHSSNFSNRHTPANTNSLVERSSKELPPLLPGQTCNCAAKLMEQESARLRFHHQQQQQQLRQNALTRTWRRLILCNWGGSGERTRRRGGRNGDQYAYQIAEIQQKQHKRAGSVSSSENFSSSRSDSWRNAQHHCGIPLRLLDPRRRHTSWLITRKTSQDSNLSSSRNDSSGSTATQSTGTWRISRSSGSTSVVLPGVRVDGHPVSSAARQSIPGGKPRLVRQAAVQEDTHELSCSPPRLGVRFLPTIPSAADSSVQLDDDTAEAASPTSSQSGIQPAPAPFYAILHGSGHPQATVSSLKDKTKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5Z6</accession>
    <name>A0A084W5Z6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Fe3+-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013633</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020708">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5Z6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013633-RA">
        <property type="protein sequence ID" value="ASIC013633-PA"/>
        <property type="gene ID" value="ASIC013633"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013633"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013633-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8814" checksum="46EF63EF7A226951" modified="2014-10-29" version="1">MPSTVRRLRKRPARDCASPITANLCLRVAFRPQLFESFLDAVRILTGCGSSSDGSQEPRRSSIIPGPSRGRATNEQRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W771</accession>
    <name>A0A084W771_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003871-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021162">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525314">
        <property type="protein sequence ID" value="KFB46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W771"/>
    <dbReference type="STRING" id="74873.A0A084W771"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014037-RA">
        <property type="protein sequence ID" value="ASIC014037-PA"/>
        <property type="gene ID" value="ASIC014037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022389"/>
    <dbReference type="OMA" id="ASLMQPM"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="387" mass="40081" checksum="B743AE4D923183B0" modified="2014-10-29" version="1">MPFPLLSHNQPPLSGSGSSSLTPRRGDGPLSPTDTDSDSDISLGTHSPVPSMSMQHSPSSLPGSSEDRLNDERDREKDFRSSFASLHSFRFGDHLTGGLIPGSFNSRFMPYRLGDNSPPIATHSPPIGLTHLPLTPTVLRPQPHLPHSLAVSAASLGAAGAGVLTTAVSMSDSPGSNSSATSASLGNALGAGGLTPTPTGVSLKDLQHPGDHSSTDGRPGTPNSEDSPHSHTHNGSTGTVPPGSTPTSTSNQPMPPMSPLRIRVSSPSRLNAELLHHTAVAAAAAAAAAASQQPQHHPLPLHHPHHPLHVHHHPHHAHHHAHHAHQTHAHHHAAALTAASMMNGLNAGGIVRIVPGATNPNTTSNTTTTTSLIHRPFSPSPKPKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7I9</accession>
    <name>A0A084W7I9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptidase C1A papain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014185</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021253">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7I9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014185-RA">
        <property type="protein sequence ID" value="ASIC014185-PA"/>
        <property type="gene ID" value="ASIC014185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014185"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014185-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="193" mass="21789" checksum="1AAA14BDA2BC2D9F" modified="2014-10-29" version="1">MTVAERRGKRKPSCPEKRGSLDAKVTSRFGFASGACNRLFNFCRFALLRNGMMVAAGPDLVWVCICAIDWCIVRAVCARALCFRCIELGWPSKYAAPPQHHPQQQHRVPTFLIASEKVRDALVLHLRLPTPPSQVGSHIYIILCTRPFPMWAKGVGAEKGMERRGKRERSDIRTMTRIVIDGESRDRVNARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8B1</accession>
    <name>A0A084W8B1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008113-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00014349</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021400">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8B1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014349-RA">
        <property type="protein sequence ID" value="ASIC014349-PA"/>
        <property type="gene ID" value="ASIC014349"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014349"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016294"/>
    <dbReference type="OMA" id="VIRTCGF"/>
    <dbReference type="OrthoDB" id="6496929at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF14">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784641" evidence="10">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014349-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="15691" checksum="7BCF3102930B6ACF" modified="2014-10-29" version="1">MMSSLQSAFLVSLLLIAVFISKGDAIRCYECNSADDSSCTHDVPPETMSVDCTEHKGGLAYKYCRKIVQIIEFPVNNLPPDTRIIRECGYDESAYKGKCYQRSGFGGRQEVCACYEDNCNGASTLSVTFGVLLFGAIAFLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8D3</accession>
    <name>A0A084W8D3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Unconventional myosin-XVIIIa isoform X26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014463</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021413">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8D3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014463-RA">
        <property type="protein sequence ID" value="ASIC014463-PA"/>
        <property type="gene ID" value="ASIC014463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014463"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014463-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="18218" checksum="7E058F513863D75D" modified="2014-10-29" version="1">MRSNKTRHMQMELAVMEASEGTLKWAIKIANLFKRSHRVEATIEDRLERAKAESNLTHFGFGMLSGFLDDRFEALEHLKGTCKYWLIDLTAPEGSHQDELTLIGLLRMVISFCFRGKVFPLVSKVSSKGVQNVRYRNHPTRRRATCCIVASEGLAKGTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8H3</accession>
    <name>A0A084W8H3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM domain kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00014509</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01021433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W8H3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014509-RA">
        <property type="protein sequence ID" value="ASIC014509-PA"/>
        <property type="gene ID" value="ASIC014509"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014509"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016024"/>
    <dbReference type="OMA" id="FLWLTSM"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09365">
        <property type="entry name" value="LIM2_LIMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000082">
        <property type="entry name" value="LIM domain kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000197">
        <property type="entry name" value="LIM domain kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF4">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="20">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="375"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1033"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1241"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1266"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1105"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1241"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB46517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014509-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1427" mass="153932" checksum="E64C746D4F37EE2F" modified="2014-10-29" version="1">MPKGDGGAGQRSGGGKKDSTACASCYNAIEPEQHVAAVGQLWHAECFRCSVCDARLSSWYFEKDGLLFCKEDHWSKFGDCCQQCSQIISGPVMFAGDHKFHSECFRCESCKVFIAEGETYTLLERSKLYCGQCYKRHQSAFVEVSRNGTTTTSSLVRGEKAKQQPLPHTIRLVEIPWTNARTDRIRLATDDKLFGASGKGAGAGCKSVRISEVTLNSDLMSLRVGDKVLEVNGTPVRDVPLENLQNLIENSAGKVLQLTVEHDPELVDQQQQQRSVNGVLSASYCGTQCPDTCNNNEDEDNQSSRSLSPSKLERIFRKNDEGYMSGSSRKLQKRLKDVNCNTGSIAAGGEFYDLSRTKSFRVEPKAARIFRASDLVQGELLGKGFFGQVFKVTHRVTQEVMVLKELYRVDEEAQKNFLKEVAVLRSLSHHNVLRFIGVLYKDKKLHLVTEFIPGGSLKELIHDSGQPLSWEQRISFARDISCGMSYLHSMNIIHRDLNSLNCLVREDGTVIVADFGLARIIKQPLLSTAYEKCSASAATPGNGNGTIGRRGRPRRQRYTVVGNPYWMAPEMMRGNKYDEKVDIFSFGIMLCEIIGRVQADPDYLPRLPDFGLNQTVFREKFCGQCPEPFFKIAFLCCDLNPDKRPPFHVLQDWLETMVTMTALNKPLPAKIVYDIEHFKGQRSTDSSLCTTPDGLATPPPSAGYSLKPSLSRKRICEGPEDTVEPQPKLSDLQTTSSLDVVDGVIGVGVRPPTVENNATPCCPDATNGFIVADCIEIPKSPHLGKDFSANGDRIRDSIRAKRRHRMMLSRENQRKSLDSSVLAARLGSDRLFADVNDVADNGSASEPISLIMTSEMIANDAAKIAEATAGGRRERPSTDELLASVKDSLELNKSLIGAGGDGIRPNNGAWGPVPAKVKHYGEKGFVIHVQNGHLTLNNVRDLENCSDFDSSCDTSLNYIEVNGNRMESESCETPEVEVKCDTVVSSGVGGVAVTSCPPPPLEPVHLSRGTCEKENISTESPPLTVLGKAKITPTQSKPNFSPFAPIPPERNGSIGNGTLPTKVEEKKQPSSAQKAVQYTRKLFRSAMEPSGNTSKPVHDLPGTHLPSSTTKGTPSSRGHTRTSSSERSALFSTKQKISPTSDPEPQPSFGVTGAGSSARPKSNTVLNSVFSYKSKPNEPSVDGARVAQGGNVFAASGSTIRRVGAKGSVGGKASPGGVMNAACVESIPPATGKPPIGTYTPAALAGSGSPGSSILRFGKSTRTYRPVEKMTTVSGESRTATGVRVEKYTTFSPPSGSSGSNSRTDSPSPPVPNGTRSSIGGTAGSRTIGILSPSSIRRLNARLLEARKGNGTFGSEQPTPTPVVPRTKVATIVSISGGTKLPGVARKVPPVTTSSSGASRGTILSAVAGCSRERRSTRCPGGPHMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9C5</accession>
    <name>A0A084W9C5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002264-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9C5"/>
    <dbReference type="STRING" id="74873.A0A084W9C5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014848-RA">
        <property type="protein sequence ID" value="ASIC014848-PA"/>
        <property type="gene ID" value="ASIC014848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014848"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023067"/>
    <dbReference type="OMA" id="HERPEHE"/>
    <dbReference type="OrthoDB" id="10062218at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039338">
        <property type="entry name" value="ZFTRAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059:SF4">
        <property type="entry name" value="ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014848-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="31947" checksum="813C4D248CBED2F4" modified="2014-10-29" version="1">MGHLMCAGCFTHLLADGRLRDQNATCPNCRTEISKANSTRNLAVEKAVSELPAECQYCCKEFPNKSIDYHESTECEDRPTDCKFARIGCQWRGPIHEVPSHETNCAHPKKSGAEVMVALQDHDAKAAEDKKLFLSLIDLLSYEKIIFNDLQMKPYRTDEYVHRLYYETSRFSAFNHQWVVKAIINKSQRYPHESCERDITYQLILKSKTSSPLPMHFFVLRGPFSDIKVNTQIYKHDFADTETESPFNLLPLPDTAECNRLLAAKSINFRLIMFLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA10</accession>
    <name>A0A084WA10_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00015163</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the chromatin remodeling Ino80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA10"/>
    <dbReference type="STRING" id="74873.A0A084WA10"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015163-RA">
        <property type="protein sequence ID" value="ASIC015163-PA"/>
        <property type="gene ID" value="ASIC015163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015163"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000053"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019219">
        <property type="term" value="P:regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000237">
        <property type="entry name" value="Actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000016">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="654" mass="75232" checksum="D0C5CA4EAF647447" modified="2014-10-29" version="1">MDISPIEDLKTIPDVVQPYPGPSGGREAVIVIDNGSYNCRAGWMLTDRPALTFRNLLAKPRKDRNKKDVDAIVVPVTQIGNDIVNIEAMRLQLRTQFDRNVVTHYNVQEQIFDYIFTKMGINTRDSIPHRIMITECLFNPNYCRSLMSELLFECYEIPGLCYGVDCLLSNYSNHRVKNGLIIATGYHTTHVVPIVDGRIVVENVRRLNIGGSNMIAFLHRCLQLKYTIHLNAITLSRSEVLLHKYGEFAYDYMESLKDWASLDYYEKNVKKIQLPYNQTATAPTMSTEQKVEKKKELSRRLAEMNARRREERLAQDEELLLQLQQLEESAEDGDDIRDALAEHSLKDAGELKRMITTVNSRIDKTRIKINTPIAGNSLPPTDTDKLLQPPPNMTIGEWVEETRRKREAILEKRQARRQRKQDLAKRRTAAAQERMRIISHLARKEKGSDDFGMRDEDWDVYKQISRDEDSDNENENERLLECEIILKQYDATYEDPLLLMSGSAAELYQLHVGVERIRAPEILFQPSIIGSSEAGLPETIDFVLKLFPAAQRSSLVENIFITGGCAKIKGLKERLAREMREILPFESRFDIEIANDPLLDGWNGARKFCLTETFRQSLITRSVYEECGGEYLKEHFNSNVYFPTPKVFADELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBB3</accession>
    <name>A0A084WBB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00015462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBB3"/>
    <dbReference type="STRING" id="74873.A0A084WBB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015462-RA">
        <property type="protein sequence ID" value="ASIC015462-PA"/>
        <property type="gene ID" value="ASIC015462"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015462"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011281"/>
    <dbReference type="OMA" id="WKVTATQ"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000310">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015462-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="23234" checksum="854FF23EBFD0A5E4" modified="2014-10-29" version="1">MALTSIGFRWKVTATQTASGGGMIANVAGGSGGIAAAVVAVIGRPLPTISETTTAFTNVSSANTSPEKGSLGNGIERDRIENDPPTAGDISMAYPSGAQASCSSASRAGGHAARKKAQSSTDSKRERKAAKTLAIITGAFVCCWLPFFIIAILLPTCTSCNISPLVTSVCLWLGYFNSTLNPIIYTIFSPEFRHAFKRILCGRRYSLRRTRNLGVRHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBG5</accession>
    <name>A0A084WBG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011439-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015523</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBG5"/>
    <dbReference type="STRING" id="74873.A0A084WBG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015523-RA">
        <property type="protein sequence ID" value="ASIC015523-PA"/>
        <property type="gene ID" value="ASIC015523"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015523"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005149"/>
    <dbReference type="OMA" id="RYEIVQM"/>
    <dbReference type="OrthoDB" id="9930272at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF16">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015523-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="490" mass="54335" checksum="0669CA65AC18D4DA" modified="2014-10-29" version="1">MNMLREWSPLVELVNKIPASVQRGLLFHDVSITCIDLVPEFIAIGTNVGLVFWYNRKSGEIERLATEGGSQELTSVRIISTVDYMVAVGCREGNLNIFQIPKTPPPDVCAELLLKAKPIERYTVRGLHRASVCELVWSKNGMRLFSGDTAGAVVLTEIGYASKTCQSREIINERYEIVQMDLRQGKLLVSSSFRTVICSPEDGGQRWRVAQVGKKDRKMLAPFGAVFATVHGKQQIVSTRSGFRLWLADDEGNVAQTLIFKELMRAPCPEIGLLNPSRNPIRIPTTFGKLYPFEANQIVSVANGALFLLDLERMAVVGTLTRLRHILDVAVDRNEILILENARSLVRIATLPDSSQTTIVLKNLELFVSAESQVVLADECYEETPVEMIRNGESPTSSAPGDDDQQTLASSSSSSTDRTDGGGGDDVRLINSHMKKLELFETLNELKYDESILFKSGRSHRRKHRPKVNPIVEIGQIPKEVEPDDATLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBP8</accession>
    <name>A0A084WBP8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015684</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015684-RA">
        <property type="protein sequence ID" value="ASIC015684-PA"/>
        <property type="gene ID" value="ASIC015684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015684"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015684-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6743" checksum="FC13ABC335887CB9" modified="2014-10-29" version="1">MTSHCAGLARKRRNEMPCGGVALELKNRHPIGPTSTGRDVISISRNAVGRKRFGKAHETSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGD5</accession>
    <name>A0A084WGD5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="9">dUTPase</shortName>
            <ecNumber evidence="9">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00017392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01023538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGD5"/>
    <dbReference type="STRING" id="74873.A0A084WGD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017392-RA">
        <property type="protein sequence ID" value="ASIC017392-PA"/>
        <property type="gene ID" value="ASIC017392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017392"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019469"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB49279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017392-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="146" mass="15643" checksum="A89A6E0FAB8E1A17" modified="2014-10-29" version="1">MPESKCVLKFAKLSENAFAPSKGSAKAAGFDLKSAYDYTVPARGKQLVMTDIQVQVPEGCYGRVAPRSGLAVKNFIDVGAGVVDEDYRGNVGVVLFNHSETEFEVKKGDRIAQFICEKIAYPDLEELPSLSNTERGAGGFGSTGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGJ2</accession>
    <name>A0A084WGJ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Poly-beta-hydroxybutyrate polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017339</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017339-RA">
        <property type="protein sequence ID" value="ASIC017339-PA"/>
        <property type="gene ID" value="ASIC017339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017339"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017339-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8589" checksum="9E162D0D20F5B0B9" modified="2014-10-29" version="1">MPRSVGPGCRYVPAWQGTVRQAFKEGTFRQKQEMRAASGVEQGDRGGDPPPPGGHGSRERKRYGEAHAARRIPEGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGS4</accession>
    <name>A0A084WGS4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP011610-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00017520</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGS4"/>
    <dbReference type="STRING" id="74873.A0A084WGS4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017520-RA">
        <property type="protein sequence ID" value="ASIC017520-PA"/>
        <property type="gene ID" value="ASIC017520"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017520"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018830"/>
    <dbReference type="OMA" id="FLEHCNC"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB49418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017520-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="563" mass="65462" checksum="88DF2E61D650B8DC" modified="2014-10-29" version="1">MLRETRVNSKNQWEPELLNESYKDEGQRSLWEDYCMNSTIHGFKYFVGSKRTLIERVWWFVVCIMSFYGCGRLIHSIYMKWDRNPVVVTFAEKARPVFSIPFPAVTICPEIKVRKAEFDFSQAYQVYNDYENEDAYLPPDQLEKLEALLQVCDFAFGIDMDNGTYDDDVVQRLQQMAIKLNEIFVTCGWRGQTIDCGHLFKPTLTDSGICYTFNSLSADEMLRKEQLHSEYEYLTENRTATRWSMDDGYETGPRNSTYPRRTFGAGIRAGMYAILRVRLKDMDYLCSNSFQGFKVHLHPPNQYPRLYNQNFRVPLTQEVSVSIDPLVIETSANIRNYSPIRRQCYYNHERYLKYFKVYTKSNCEIECLANYTIKMCGCAHFVYPRTGGERICGLGMSSCCNRALSVLEELDLLQTKNVSVKLMNQCNCLPACNGVIYNTETSQARFDWRKLLEQINPSFNSDEIELSYLSIHFKVPRFIPIKRSELFGVSDFLANCGGVLGLFMGVSILSIVEIIYYCTLKPIMERNATSRELFTPKPIKSHLILPPEEYGVPIRQRKDITKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHG7</accession>
    <name>A0A084WHG7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHG7"/>
    <dbReference type="STRING" id="74873.A0A084WHG7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017760-RA">
        <property type="protein sequence ID" value="ASIC017760-PA"/>
        <property type="gene ID" value="ASIC017760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017760"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012517"/>
    <dbReference type="OMA" id="ICIFIGC"/>
    <dbReference type="OrthoDB" id="8768722at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000006">
        <property type="entry name" value="uncharacterized protein C16orf52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037663">
        <property type="entry name" value="Mosmo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186:SF1">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18800">
        <property type="entry name" value="Atthog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="167" mass="18619" checksum="0BF8AA1248515EA7" modified="2014-10-29" version="1">MDKLTTISAALFMAADVCAIVSLAMPDWIVTSVGGETRLGLMWTCMTLYNRPQVCFTPELQPEWLIALICIFVGCICITTTIILLASSNWDRNVIPYARWVGFTAMVLFCLAAVIFPLGFHVDEIGGQPYHLPHSHQVGISYIMFVLALWITVISELFAEKVCLPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHY2</accession>
    <name>A0A084WHY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP012273-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00017846</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP130 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WHY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017846-RA">
        <property type="protein sequence ID" value="ASIC017846-PA"/>
        <property type="gene ID" value="ASIC017846"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017846"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000933"/>
    <dbReference type="OMA" id="NHFQRYT"/>
    <dbReference type="OrthoDB" id="10048604at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024137">
        <property type="entry name" value="His_deAcase_cplx_SAP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031963">
        <property type="entry name" value="SAP130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497:SF3">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16014">
        <property type="entry name" value="SAP130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP130 C-terminal" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
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        <location>
            <begin position="1158"/>
            <end position="1174"/>
        </location>
    </feature>
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            <begin position="1301"/>
            <end position="1312"/>
        </location>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF16014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017846-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1629" mass="164081" checksum="924038D9B1BAB6AD" modified="2014-10-29" version="1">MSATEGAGGGDKSSSSSGPQTVPGGAGKPVVTTAIPIDLASASKVLVRPEKTTMPTTTYRFGSTAGSQMRVVIPSSAAPQNFYRQPANIKQDATTNRTQISAISAARTVTQTTSLTVSRAPQTTPTTVSYHVPNRVSATPVVGASLQATARATTINGPIRISTPPIQVATNSTTAFVQRQAPTVVPARNVTTSSASTGAASSSTAATIISQNQSGQSGTTTLVPNFQMSTQLLRANSIAAATGGTVTGVAPRARVVTQTTLPTNHHQVSVNSGGAGATAVVSNVVSGGQTTGGAGAPQTIAISGAPGGGGGGGGSASGGNSGTSTGQTNQSPQAFVATLSAVLQAPRQVSTLVYTNNSNAQQYTIGPNQQRLALATTLSPQRPPQATTVTTGIRPTIQRLPTSAANIRVSNGSLNFRPPVLASTTVLTTIASGGAGTVGTVTTTQQQQQQQQQQQQIQRPVVTATGGATAISNTIPARIIQVQNPQSGTTGTAQIVNGRIQTNLLNIQPLIVASNNRLPQSALQPGLTIAQVGKLTPVATGGGGGSGTGATADGSLGTTTLQTASGQQIVVSTGVGVGGSGSTSAAILAGSLIATNQSGAGGGSAVSQQQSASGQITQIVNVNAPTVVSVAGGTGSSNQSQQQQIVTVSQATGVGASSAGGATVIPLPLALTSARSVGGGGGGATGHSPLSIVTGGIVRTAAAGGAGVTGVATSLSSVLPIAKVTPQQQQTLVSLESSSVAGGGGVVTQHYSVAGGGGGTGPSLYIQTRPQPQGTATGTIIAATGGAGSAPGGGSAKGTRHSVGGGSTASATTFLPTSTFYYERLTSSPATSNSSSNVPSSSTSAVSSASSSGAGSSTVTLVQSASSAASSSAATITTTSAISGPVFSIPSSSSVISSGSSGSTTTVVTVAGGAGSGVGLNPTLTPYGTSGSFAIVQASAASSSASSSANAGGGRTATLTSGPIHGIVPASIQGSSATVTGSIVSVSQQSGAAGGGASSATQIVPIRFHPQLIVDSSGQTQQIIVSSGASGANIVPLIPVSGNRNTVGNNNTTTTATVVATSKQQQQHHQQESPQSSILRKRALVESVALKTTPVVKDLTQALMVVEREREREQQEAQLQFLQQQQHQQQQQQQQQRHQHLVTELRDMAGTPPLSHSRPPSTDGSTTVSATSSPGLDEQEEEEVRAQAYANRNSNAISGDGHFKPVQGELHYLQQQQQQQQQQRDIMSLHCTESFPTNLGTTTLTVVPIANHTVVSVAASGKNGDYEQTPRKKARKQLHLPMSEAAGGAMLKTINTTGVVSSASTGNNSAHQTSSTSTTTSTTTLFVAENPQAEATPKATDEERMDTSGSGIVVLGTVPSSSSASSSSSSSSSSSSSSVTGQMVSSQAVAGSKHNSLSVVASVTSSTMANSSTISSSCSSTTNVRMDPPVVSSTSTANTTVQQSQAPGTTVVVATPKPNTALRKHNNYSLLQSYKQTWKAANNHFQRYTDVKQREERRPTVMDIANQSHILQKVNGWKIYHLSAQIEDLCDLESQAYGNLGQMLRAMESASSSHGGASGSNSSSSVKSSTDIERINELLKGNMQRSKIVMDGINEARVQIMKIFKHKPHVSDILVRCASKRNVKKREKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIB6</accession>
    <name>A0A084WIB6_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Zinc-binding alcohol dehydrogenase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017997</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB49960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017997-RA">
        <property type="protein sequence ID" value="ASIC017997-PA"/>
        <property type="gene ID" value="ASIC017997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017997"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017997-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="7762" checksum="E6D59AAE5B41040E" modified="2014-10-29" version="1">MVRHARGDSSIELNSVQSRELQPAIQRAASRGPNRYRGGESSSTYRRHFHVVVRPSPLPSALCEQEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIH0</accession>
    <name>A0A084WIH0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Lamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018056</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIH0"/>
    <dbReference type="STRING" id="74873.A0A084WIH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018056-RA">
        <property type="protein sequence ID" value="ASIC018056-PA"/>
        <property type="gene ID" value="ASIC018056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018056"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021098"/>
    <dbReference type="OMA" id="GYEMIKT"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="344"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="497" mass="57012" checksum="FBD4C7B8AF2B36EA" modified="2014-10-29" version="1">MVWNHKWQQHNMPHGVAPGDVGNLVLYLGIEQQRRSKSARKLSRLSCTFVRLHKQPQHESNDDDPRVVADRNILERKTKEAADAERSARAQESRANELSGKYTTLLSEHKKAKDEQKELEKELARLKKQLDVLRKNLEEETLARVDLENTVQSLREELTFKDQVHQQELTETKTRRQVEISEIDGMLSEQYEAKLQQTLQELRDQYDMQLRANREEISDLYETRLRDLELQMNEERVRHAAEKSKMMDEVERLRKEISQQLQDYQDLMDIKTSLDMEIAAYDRLLSSEEVRLNITPGSQTTIFSTSSSSSMARSSGPVRRTPSRAAAAKRKRTVLEESDERSVSDYSVTSSAKGDVEIVEVDPEGKYVKLHNKSSKEVQIGGWSLIRKVGTNETAFKFHRSLKMDGGAFVTVWSSDLGKDHEPPTTIVMKGQKWFAGDNMSTQLLNSDGEEVAASERVKRVISTAASRHREYLGSYGGEELYHQQGEPKGDEKCRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIT5</accession>
    <name>A0A084WIT5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM8</name>
        <name evidence="15" type="ORF">ZHAS_00018186</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIT5"/>
    <dbReference type="STRING" id="74873.A0A084WIT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018186-RA">
        <property type="protein sequence ID" value="ASIC018186-PA"/>
        <property type="gene ID" value="ASIC018186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018186"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005691"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000022">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB50129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018186-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="10387" checksum="280FDB1D853908C9" modified="2014-10-29" version="1">MSGLESYVNNTVSIITADGRNFVGTLKGFDQTVNIILDESHERVYSMTAGIEQVVLGLHIIRGDNVAIIGQLDESIDSKLDFTTIRGMPLEPVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIX7</accession>
    <name>A0A084WIX7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00018234</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01023952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIX7"/>
    <dbReference type="STRING" id="74873.A0A084WIX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018234-RA">
        <property type="protein sequence ID" value="ASIC018234-PA"/>
        <property type="gene ID" value="ASIC018234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018234"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021469"/>
    <dbReference type="OMA" id="MRLGCNQ"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018234-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="29842" checksum="48C5CE00530B8A25" modified="2014-10-29" version="1">MGSGIAMITAANGYQVTVVDLNEEALARGRHQVEKDLQRMAMHVSKGNEEKANQFYLAALARLNYSASLEKVLSATDLVIEAIVENLEKKQALFKIIDQGALPHTIIATNTSSLSVKEIGSTTQRQDRIGGLHFFNPVPLMKLVEVIRTDSTSDSTHEALLAFGKSLRKTTITCKDMPGFVVNRLLFPVISEAVSMVERGDATAHDIDVAMKLGLGHPMGPFELMDIVGLDTVQNIQKERRDSAVKPSALLEKMVKENKLGVKTGEGFYNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJD5</accession>
    <name>A0A084WJD5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Defective proboscis extension response, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018598</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJD5"/>
    <dbReference type="STRING" id="74873.A0A084WJD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018598-RA">
        <property type="protein sequence ID" value="ASIC018598-PA"/>
        <property type="gene ID" value="ASIC018598"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018598"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004711"/>
    <dbReference type="OMA" id="QHWYVCA"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001633">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF7">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="104"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018598-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="31611" checksum="CA1808A86EAA9A5C" modified="2014-10-29" version="1">MMTTTTEESAALQPYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVAWIRQRDLHILTTGASTYTSDQRFQVIRQENSVNWTLQIKYPQVRDSGVYECQINTEPKMSLSYRLNVIELRARILGPSDIFVKSGSEITMTCVIQQGPHELGTVFWYKGNTLIEPANQENDIVSSEHRRIIVETDWTDVLTSRLKIKRVVQSDTGNYTCVPTMAKSASVYAHVISGEHPAAMQHNAAATFSQSLLLQTLYILILFGQVQQILRLNFFRLKAYSNASVSGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJG2</accession>
    <name>A0A084WJG2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00018628</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024026">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJG2"/>
    <dbReference type="STRING" id="74873.A0A084WJG2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018628-RA">
        <property type="protein sequence ID" value="ASIC018628-PA"/>
        <property type="gene ID" value="ASIC018628"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018628"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014467"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF329">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB50356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018628-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="353" mass="41705" checksum="30C61ADA3F1DC09E" modified="2014-10-29" version="1">MECCLSEEAKEQKRINQEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFIKLVYQNIFMAMQSMIRAMDLLKIQYSDPANIEHAELIRSVDFETVTTFEPPYVQAIKDLWADAGIQECYDRRREYQLTDSAKYYLMEIDRVAATNYLPTEQDILRVRVPTTGIIEYPFDLEEIRFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESENENRMEESKALFKTIITYPWFQHSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAIAAREFILRMFVDLNPDSEKIIYSHFTCATDTENIRFVFAAVKDTILQSNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJP4</accession>
    <name>A0A084WJP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005771-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WJP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018468-RA">
        <property type="protein sequence ID" value="ASIC018468-PA"/>
        <property type="gene ID" value="ASIC018468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018468"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006490"/>
    <dbReference type="OMA" id="PQTYSIC"/>
    <dbReference type="OrthoDB" id="69656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000007">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000518">
        <property type="entry name" value="Receptor mediated endocytosis 8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2421"/>
            <end position="2443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2443" mass="274649" checksum="FBD0383A64174983" modified="2014-10-29" version="1">MAAGTADHGVDLECFLVTKHSWKGKYKRILSIGSVGVSTYNPDKFDPTNRWLYGEVISVLPNRSGNTAYEFVLNLRKDKKIDTIKLSSENRNEILTSLLKYHKEFAEKPKQASKFNAYKHHWSGTTLPTVLEVTPCSLDQLDPTTNTVLASYNYKDIDGIIGIQDYKNGIVLAYGGHSRLHLFRVENNHDIVQMIVQNAQQYLAIDIKVLKKQITLEQFEQQRFGAYSGDQHQTSMSEFTVLKVTPRHSEPMRRILCLTDTTVLERDPQTYSICTLRPLDNVYALVRHADNIQQFSIEYKNGLVRSYITNDRDSLLATLLDAVRSCGNQDVHVRISNTPRGKRVGPLTVSVDEETEANLLRYIISCYQYPVKRIDVMERFNANIPYSGLNYSVTQDSLFAESKERLITGALQALISGSKEDNALLTNVELEASFHVLRRLLASKAGFAAFTNLPGFREAIGLKVVHALKRNDLAVTYAAIDMINSLMHSDHDLKQEQLNKSSLLHTKAFLEQLLDMWSKHVNLGSGALVLSAMLDFLTFALCVPYSETTDGKQFDMLLEMVAARGRTLYKLFQHPSLAIVKGSGLVMRALIEEGDAAISSQMQTLALDEAALCRHLLVALYTPTNDSTMIAHRQLSRHLVGLWITDSPEAMNLLKRIFPAGLLAFLESEEAVPKEDVEEDRLNFRDNLKLAVQHSGNNTKRLNYLIEKHIEGIKHWGMNLLDVRQEKLQQAQKNRPIVLRNRRNQKKKAIGEQGAVNLPLFFYQFGKNHAMPNLIWNLKTREELRAALENELRQFTADKDLAGNMLVAWNYDEFEVQYACIADELKIGDYYIRLLLERDDWPSNLVKNPIELFNALYRRVLCRNRLNDDQLTVTSLKALAKVYKRYYEEIGYFSDMPYILQMLDRCLSPALRDALIILIKNLVLHKSNCRPLVDHVNYLVDLITLAHLHKGRATLNTKTNVIEAGPNMKLHEEKDWYYNVERGDSERPERCGPVTFSELRELWGKGVLTPRTRCWAVGMDGWRSLQQIPQLKWCLMAKGTPLFNETELAQHVLDILNQCTSFFPSRARDGEAVLIPGPRLSRKLSEFICLPHIVQVCLTHDPGLLERVATLLCQIMEDNPEMSKVYLTGVFYFMLMYTGSNILPIARFLKMTHMKQAFRSEDSGSQSGIMHRSILGQLLPEAMICFLENHSAEKFAETFLGEFDTPEVIWSSEMRRMLIEKISAHIADFTPKLKGHTMARYPYLAIPVISYPQLENELFCNIFYLRHLCDTTKFPNWPIPDPVQLLKHTLDAWRKEVEKKPSEMTVTQAYLDLEFDVSKNPHPEEAAIRKAYYKLAQMYHPDKNPNGREIFERVNRAYEFLCSRNALNTDGPNPSNIVLILRTQSILFERYSEELRPYKYAGYPQLIKTIRLETKDDQLFSKTVPLLSAASELCYHTVHCSALNAEELRREEGIEALLDAYSRCVSIMGVDSKRDALHYEVISNITRCFDVACCFDSCRRKILELPQLIVDVCRVVYFKHSLSVSLVTSLAVNNLELQCDLVRNGVLWSLMMFLFDYDYTLDESGVTSEEKSNQQQVANNLAKLSLLACVALAGYSMTLVDDPKAAVLKVTAKATGGGGGSVSPGSRSGSPQTAQVGRVPNQTYSQNASNLIQNNSSLIQSVAVIDRALQERKGSDVATADGEAAEPIECEKGLQNKKYKISNVQPPANGVVKNILDRLLTPYVAGKMVTDSEQEVLKMLNSNTRNPYLIWDNGTRAQLTDFLEHQRTNASKEQYEDVTQIYELVQGFSFDAHRDELKIGGIFIRVYNEMPTFTIVNPKSFVMDLLEFLKQGYNHLNGIVDGPASAAAAAASGAMSPQSSHPTAAILGGDILVPTKTWKPMVPPPKRPPAAVPGNDISAVLSEYARSKQRSQLGKAASIEASGAAPAQRYDFASDPHAIRHILMALQALISVLQSNANVEIQCIGHFEMLFGLLSTSQCGQENRAVKKLALEVVCLVSRNKECVTEIAACEIVGLYLIVLKDPDLSEHLARVLETLSGLLNAPKLIKEAHAKGAVIYLLDLFCNCNNPQIREQCAELLAKMNADKLSGPKVRITVCKYLPPVFLDAMIDSTSVAVQMFESIHEHPELIWNDDIRASVSDAVRDGADSFHAAQKRNARTAWRDPDILPELLSNELVVSGVYLRLYVSNPGWTLRKPKQFLADLLDFIVENISRAGVDKGVLDLATTALVLLLNAQPNLADSIPVLGHIPKFFRQLSVQPKSALTVLHQLSLSEICVSAISQTECIPSLKSCMEHHRDLTATACETLSRLFKCQHDSLIRQSLECQLIPYLLALLDSRFELATNPAMVKAQIVAALKAMSANLTYGDRVTHLLNQNPIWAEYRDQRHDLFITDTDVRGYLMGAPTTTAGYLTQGPTKNVEVLTSPPPIDRDDPLFARSNSSGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJX1</accession>
    <name>A0A084WJX1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">CCAAT-box-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018555</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJX1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018555-RA">
        <property type="protein sequence ID" value="ASIC018555-PA"/>
        <property type="gene ID" value="ASIC018555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018555"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018555-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9549" checksum="E34AEAD7FB6C1537" modified="2014-10-29" version="1">MMLERLFSTSRPSHLFHNRPNPRVGLVYSSLIIPEAGFWVSAFGSVPADSSRPTRVSSPLVVNLRDGSFARRETRATHKNPRGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK12</accession>
    <name>A0A084WK12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Catalase/peroxidase HPI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018793</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK12"/>
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        <property type="gene ID" value="ASIC018793"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018793-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9188" checksum="9D81B5A3CB0F743A" modified="2014-10-29" version="1">MKDTEGGRPAGRGIKTAPETEHSNNEPRTQKKELTFCRNNLLKEVYLTECTENIEAEVVASGGNAYIPHPAIPVVGIPFLPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKW1</accession>
    <name>A0A084WKW1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019198</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKW1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019198-RA">
        <property type="protein sequence ID" value="ASIC019198-PA"/>
        <property type="gene ID" value="ASIC019198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019198"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019198-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7396" checksum="A42F16750D4ACA6E" modified="2014-10-29" version="1">MRLTHRTERSSHSVVLADTASPFSGPVQIDSVSGMGGLVGIPSRGLKVDGGCFCCDPMLERFAQTGSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WM76</accession>
    <name>A0A084WM76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Tuberous sclerosis complex 2 (TSC2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00019374</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WM76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019374-RA">
        <property type="protein sequence ID" value="ASIC019374-PA"/>
        <property type="gene ID" value="ASIC019374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019374"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000895"/>
    <dbReference type="OMA" id="IRWFTSC"/>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1895"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="2165" mass="237209" checksum="1439A36A3F28B23F" modified="2014-10-29" version="1">MTSRERETHLYRLKQFFRINRSGSVSSSRNDLPISPELERELRPETPVTQRCKALKDFGEQVMSSRLEPDAVQSLWELTKDLLVGNKLMEQRQCALAFYCKLIQGQYDSLGLMRAQFYRVIVSHSEPEDIGYRLEMLKQLTETGKNIQHFEKEIGPFLLEWIKPIDEAGLIDPLLELIVNLIKYNAASLEPKFLVGVVSYIFDMTCKKQETPTILLCLSVLDCFICYAIIPNESLTLFIIILCRMVNQEAYCQHSWKIMKNLFGTALGHATLLTMCNILNNPAFHQDDALLRGAIFHTNVGLWGVGGCVVPILNCSPSLVLTSFWNALKSRHVVVTYEVILSMNRLIQKSGTELNEPTWDIICDIMTEISHNLAIHRLPAEHTVLTHFHDTLNIMEGILQQGAMNADPEKIYALIEKVSAERPEASVKRLIDYKASKISATRSEWLRQLCQFMDRFYRMKNSNVRIYAVQALERIMAANRAAYEDEILERIVIVHLGSVPLEKDAEVRKAVARTLIEFTIHCETKRCIELLEIIEKLLHRPYEENHEVRTEHEVEDVILLVDGLIRLFIVKLYRLPSLHAIRVYSMLIGLLELHYQKPNVLANVSTIRYRIFAWMMKARANGSFHIGYPDPEDDNRVRFSHYLGIEGPYQHQSLQPQPYLSSQSSSQLNLTDQPGGGTERSSMDRIPATNLTTISIKRGCQVIVLCLKEEKDWEVIQLVLTELPNVMQNKALIQGNDVDSLARTLYRMYTDRMQLEKLQVPANMLPKVSDYMELILPALSSLAMYHQHLDFNTQKNIIEALKLGLISRRAQDCIRTLTILLLEMPEQLMPKMADLLLEQSKMTSTKTVALPVLEFLSTLILVPSFRFGNFNTRTYMCVLAMSLPYTNPFRYDHYTVSLAHYVVAAWFIKCKLPMRHQLVKFIVQGLESYVKVPFQDGSRSFSQANEDSSERKRSSSLTEQSSRRRDRIQAQQQAQQQQAQQQSQGSQQKSQQLSNTPGGQLLQQQGQQQAGQKGGVSGVSVSNSSSTQRVYPVSGLNDDMYKFHCELAETCVDFMVRHTFSPCSGISKRLPSAEFLLSGGQSMTWLVGHDLITITTSGCSGVNFRNGLCDRCHHASSGKDSGLSGIGGTTSHHHAATAATMTTDHTDGKLLPAVENGGGTVVPATGGQLSTTASNKRYTKASLQHSSANESDSTDLTTSSSTSSSTAATPFPAGPHSAHSTGPMSAGPGGSASTVGSSTAGNRFFRQGSQEGYSSGSLEALSRRGSNPDSVDHGGPPGAAGGTGGELLRTSSLVTPRPGLMATIGNRLILPQQLGGSMTAGGGSSSSSGIGFDKPVQPCACVCTGWAEVSVRRPTGYTSWITRIQSQVSHDILGGDVALQDLTCLFSPSVGGGIVGSEFSTYSGTSVPQGYGTGGGGGSDSLTPFGSNADIPATMTDRFVQSDAPNAVSASGIGGVVSSRAKVSISDDVFELTKKVDPKKKHSVEEEHEQSEDEELKNVLQAGESGSLSGGGSGPINIPRNKHPAASSGRGRYDDHHEGVVFDDAEGRSMRKTVRRVNSSPEMGSKWNSKYLSKAKVDVAGQPLTMAEAGGVQPDVSMVEKKKSSTYGKGVSCEAIPEEIAGSTPPPPSMLRTLPGPTVDPMPTPMAPTVRGTMAAKHQAEFSAAKSAITTSLPETNTLEPSAGGLAPRKQHSADDAMTSGTNQARSTLLDGGASNETINLPPGTGGTSMVPASANTIAPIALHPITQTSSASALSLKLPMEKVTSKPPQSPVPLSPRLLARNTANLKQSNSGTASPSFPSMMAGGGIGSGVGIGGAGSNDNDVPRGRSKTISTVREHYSRDGSKWSASNVARIRNEHLSRTVVSPSFVFLQLYHHGQFGPERPVLMDKDPEKAIALLDLIPPFEMHKIGVLYVGPGQAGNETEILKNRYGSLRYAEFLSSLGTLVAIKDAKEKNIFIDLEDGAFTYIYQDDIVQITFHVATLMPNKKQDPHCNEKKKHIGNDFVTIVYNESGEQYDLKTIKGQYNYACVVVEPIELNSNRVFIRSKDDISQHVTRETRIVSDHTAPLLARQMALHANLASLVAQSLKTKNSSPYASNWLERLRKIKNIRSRYGQQLLEQEQQKQQLQQQQQLQQGGSANDLSSTASTLGGGITYRVDDFSKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMV1</accession>
    <name>A0A084WMV1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP006812-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00019611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024517">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMV1"/>
    <dbReference type="STRING" id="74873.A0A084WMV1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019611-RA">
        <property type="protein sequence ID" value="ASIC019611-PA"/>
        <property type="gene ID" value="ASIC019611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019611"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015321"/>
    <dbReference type="OMA" id="YVKVQCG"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB51545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019611-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="377" mass="41997" checksum="6AF0C277396C9E36" modified="2014-10-29" version="1">MFSTPSPTLVGVRSHGPGGGSSGGGSGGSGGGGGGAGAGGSSGGAQPPNVHSTGSNSSIMSNIIPLDMNDYDYDDHENNDHEEVDSDDDYRYPPQPNPNIDTNRIDEIPAKEPNINAVPLKSALKKKGSNPGTPTQDNRALAVRNDMNPSATIKPVLRPRIRICSRPMRFQIGLPSTMENKENTRPYVIREAGDDSDQSDGPICYRDEDADRAAKIARKESLSIKLALRPDRQELINRNILQLQSDNEKQESKEAIGARLIRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKRYLLRKLSFRPTVDELKEKKIIRFNDYIEVTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMAVHEGSRHLTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN88</accession>
    <name>A0A084WN88_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007460-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN88"/>
    <dbReference type="STRING" id="74873.A0A084WN88"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019767-RA">
        <property type="protein sequence ID" value="ASIC019767-PA"/>
        <property type="gene ID" value="ASIC019767"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019767"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005565"/>
    <dbReference type="OMA" id="YFYKYYK"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF137">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 3, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019767-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="9652" checksum="9372EAAB45BD8123" modified="2014-10-29" version="1">MEQKFNEAAEKVKTFTKRPSDSELLELYALFKQATVGDNDTEKPGMFDLKGKAKWQAWADRKGTSKDAAMEAYVKLVDELSAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNL0</accession>
    <name>A0A084WNL0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Twinkle protein, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00019959</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="ATLV01024620">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNL0"/>
    <dbReference type="STRING" id="74873.A0A084WNL0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019959-RA">
        <property type="protein sequence ID" value="ASIC019959-PA"/>
        <property type="gene ID" value="ASIC019959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019959"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014359"/>
    <dbReference type="OMA" id="CLPHGLK"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000845">
        <property type="entry name" value="Mitochondrial helicase twinkle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SF4 helicase" evidence="18">
        <location>
            <begin position="391"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB51804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019959-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="671" mass="75861" checksum="63D2A754225014A5" modified="2014-10-29" version="1">MFVKRLILSYTKAVHRLNRLPNGGGKSSSDYEFGAPCSFLLRRPYSLDANNPNDDGQKPVTVSLYQMKKIIKCSNLGESVEGATCIQTFCPVCHTVPGVPEPTATPTRIYVNKTTGNFTCSTCQYLGRWDHIEKFFLPYNRSVKTVQELLKKEQIGVLHPLPHDSVPLDLESAKEAIRQLQLENILPESLVTVRAHWNEQRKELSIPLVDVEERTIGYKTLHAGPDGEFYERTVPKANASGLIYLRCPSSGVSTKVKDHQSQTNAILVLNVLDLLALGSVKQNATAVCLPHGLKNLPQQCLPGLERFQRLTLWFNYDTAGWDTARNYAKKLDERRCLFVRPTDQHPTPYKALLEGNIEPRTILTKAQPILHQSITTFRSLRQDVLSDLQNIDKVQGVKWKRYPTLNKLLKGHRKGELTVLTGPTGCGKTTFMSDYSLDLAQQGVSTLWGSFEIRNTRLAVTLLRQMVGRPLDENLSEFEQWADAFERLPIYFMTFHGQQPIKLVMEAIEHAQYVHDIQHVIIDNLQFMMGVQEDTKHLDRYWKQDAIIASFRTFATKRNCHVTLVIHPRKERDTDELTTSSIFGGAKASQEADNVLIIQDKRLTSVRGKKYLQVAKNRYSGDLGIMPLDFDKASLSYAQRKKKPDGSTDDGGQVEGPSGPPDDRTVRRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WP12</accession>
    <name>A0A084WP12_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004273-PD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024813">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525361">
        <property type="protein sequence ID" value="KFB51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WP12"/>
    <dbReference type="STRING" id="74873.A0A084WP12"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020124-RA">
        <property type="protein sequence ID" value="ASIC020124-PA"/>
        <property type="gene ID" value="ASIC020124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020124"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004202"/>
    <dbReference type="OMA" id="EESFWRN"/>
    <dbReference type="OrthoDB" id="47923at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3970.10:FF:000001">
        <property type="entry name" value="synapse-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB51956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="507" mass="53819" checksum="042C6DC131992666" modified="2014-10-29" version="1">MFSGLTNQVSSWIGAAKGEPQDEEVPTPPNSAATTATATTSGATAAPTAAADTTGAAAAGGDGGDKSPTKGGVFSGVSSKVTGWLGNASIPSMPAIPTVSMPAMPAMPSMPSIPGLRKTNQTDENGGITNEGLVTSPEKASQGIAGSTDAADEEDRSRYISATGGADSRPATGPGTPTEENAGQIGQVTHKVTAGAKSIGSFLYSSFNKAGDKIKHLKDNSILGEFSKEQEAFIKNQQGGGSAGVCPWVGHANEAKIKEEILSLSADRRNFVRAPPAGVEFDFDYDSSYPVALAIMNDDKELEKMRFELVPKIITEENFWRNYFYRVSLICQAADLGTLGDHNEFVKRGVSEDTEDADPSRTDVSKPVLNESTALERSAEPILPAKPSVSDTVRTSATHSDVAVPSGAIVNVAKKGNHSEFISDSFQTNEQDLEEVKAGMKKLGIDSLARQANESILHEVEKSEEQWEKDLEAELQDYELVNDGSNERNANWEKDVDELLDDETDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPA0</accession>
    <name>A0A084WPA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Odorant-binding protein 56e, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525367">
        <property type="protein sequence ID" value="KFB52044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPA0"/>
    <dbReference type="SMR" id="A0A084WPA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020228-RA">
        <property type="protein sequence ID" value="ASIC020228-PA"/>
        <property type="gene ID" value="ASIC020228"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020228"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015095"/>
    <dbReference type="OMA" id="CIHANNP"/>
    <dbReference type="OrthoDB" id="6610259at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF2">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB52044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020228-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15666" checksum="73C47D0DF5564E24" modified="2014-10-29" version="1">MAKTSAMMRLVCMGKHKASEQLVDGLGRGEFADSKDLKCYANCVLEMMQAMKKGKVTADSAIKQIELLIPSEIAEPTVGAFRLCRDAGKQMFGQDALWQQFNRSSLRFVFHPLANGIKNPCEAAYALLKCIHANNPKYFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPI3</accession>
    <name>A0A084WPI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000671-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00020450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPI3"/>
    <dbReference type="STRING" id="74873.A0A084WPI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020450-RA">
        <property type="protein sequence ID" value="ASIC020450-PA"/>
        <property type="gene ID" value="ASIC020450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020450"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019232"/>
    <dbReference type="OMA" id="VNDIAHV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB52127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020450-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="23231" checksum="5288BCF099FDB4C8" modified="2014-10-29" version="1">MAKKTYDLLFKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTIELRGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNEKSFDNIVKWLRNIDEHANEDVEKMILGNKCDMADKRAVRKERGENIAREHDIRFMETSAKANTNIEQAFRELAEAILDKTAGKETTDNPDRVVVNRGSGERLPAYKACCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPR7</accession>
    <name>A0A084WPR7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000066-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00020320</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPR7"/>
    <dbReference type="STRING" id="74873.A0A084WPR7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020320-RA">
        <property type="protein sequence ID" value="ASIC020320-PA"/>
        <property type="gene ID" value="ASIC020320"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020320"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000135"/>
    <dbReference type="OMA" id="SEYKCLM"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000003">
        <property type="entry name" value="Putative transcription factor SOX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="921"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="921"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB52211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020320-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1051" mass="113012" checksum="B0C1F5C619522DA0" modified="2014-10-29" version="1">MSSKRKSPPNKLSNAVTIEKNNFKKISLKNEEFIKASPVKELNCAFDTNFIAMQKMSADPKFLKHTDLISSRHDEHLMPLEHDFHYNLPFLNVASYILKGSDPGLGRAQDNFQLTMNLDNLNISNNNQQEPATPTSPNPVPGPKVAPGAGGAPRKINNMILNHLKTIVDNFDSLNNNINDKNSYTGSGTQNNNNNNNNNQNNNNNNCQPEETHPPSSPEVPTMAAAGSTHQQLNNQYVEKNNLESFRSRLDERITNLQLSMSEIYLMRLNLSLLDFPNEIPNTLLNNHTQHSNTVDDNTPNMNCNSSQNNIKLIKRYTNAGGLCFWVWWLHTSLFTTRVQNFTHILWATASEIVPFLFTSLSAPINQNQPQTPSNRSFKESLYEKEKNINRLIMYFTIWREMLLKAEFGESRKYKLNNNSKSNLDQPPSCLLGGSAATAVSGGSEGSRGGPAGGGGGSSSSSSAMSPPAPIGLSSSCSSSTVTAAPSATAQMCSSPGLGGAAPGTIASTSATATQSPTGATIIDCDIAGAGPDGAASTGEPENCIRRYQNVFQSIASKMSDGHGGLVGHVGIAAQLASAFPATAVPGSSSGPRRNSRKRTQQQLMAPDATDPELAPMLLAKQPMLAPPLNCGSSASGSTLTLYEEYEQAKQEQENQRYHAKEPDVPINLSKRKPSRDSPSLLPPLELPNGTKLGGSSGGGSGGGGVGPFGPGGLFGACEADDISHRLELIVPGGVALLDKDCTDKYFLHKSKRDRLELDPNHLFDYGAQDPGMGAKHPKLSIYHQSPSPHHSSPDDKQSLLGEASSYPLPPEFFLKTGGTHGGGAGGGGGGSGGGSGGGTPVMSPFNSSSMLDNMNRHLIQRQQSLGVGGGGGGGSGGGGGGGSGSSKKDKGGMGSLGALELGADIGSSRSRSSSTEKNHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMTNLEKQPYYEEQAKLSKQHMEKHPDYRYRPRPKRTCIIDGKKMRISEYKCLMKNRRQEIRQFWTRDYDSGTDQKCSLKDGAKVIKNEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPW2</accession>
    <name>A0A084WPW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020371</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025134">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020371-RA">
        <property type="protein sequence ID" value="ASIC020371-PA"/>
        <property type="gene ID" value="ASIC020371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020371"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9549" checksum="5C4657A93891225B" modified="2014-10-29" version="1">MSPSIPNTGCVGQVAGADLAADFVLRASSSATYHLQHHLHLQLGHAAAGPQVLLTAGDTSDHLTMLTGRSDDDEDDDQEDHGMASHSCNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPZ4</accession>
    <name>A0A084WPZ4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="17">DHPDHase</shortName>
            <shortName evidence="17">DPD</shortName>
            <ecNumber evidence="17">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00020407</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="17"/>
    <dbReference type="EMBL" id="ATLV01025144">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPZ4"/>
    <dbReference type="STRING" id="74873.A0A084WPZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020407-RA">
        <property type="protein sequence ID" value="ASIC020407-PA"/>
        <property type="gene ID" value="ASIC020407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020407"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003443"/>
    <dbReference type="OMA" id="SIHCQLQ"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 17" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="989"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB52288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020407-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112354" checksum="D6DD303FD95DD314" modified="2014-10-29" version="1">MSCASVLTSKDLPDIESLLALNPRVKQNCSLVPTTVTKKVKKHWKRNADRSCTSCTPLTNDFSDIKHTTLSERGALREAARCLKCADAPCQKSCPTQLDIKSFITSIANRNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLAAVEEGPINIGGLQQFATEVFKRMGLRQIVPPNVAPLKHPNKRIALLGGGPASLSCATFLGRLGYRDVTVYERRSYLGGLSSAEIPQYRLPVDVVNFEVQLVKDLGVKFELGRSLSAKDLTVRGLLEGGGADAVFLGIGLPEPKIDPVFANLTEEQGFYTSKSFLPQVADGSKPGLCACKQTAATRLPVLTGNVIVLGAGDTAFDCATSALRCGARKVFVVFRKGNNNIRAVPEEVELAREERCEFIPFMAPKEVILRAGRIAAMEFYRTEQDEAGNWVEDPDQVTRLKANYVISAFGSGLYDPDTVAALDGLKMNRWGLPEVDPRTQQTTLPAVFCGGDLAGAAETTVESVNDGKTAAWYMHCYLQGLPFDTRPELPLFYTAIDQVDLSVEVCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFAVTKTFALDKDTVTNVSPRIVRGVTAGQNYGPQQGAFLNIELISEKCADYWLAGITELKRDFPTKVLIASIMCTYNQRDWEELATRAEAAGADMLELNLSCPHGMGESGMGLACGQDPELVYHISQWVRAAVRIPFFVKLTPNITDIVSIAQAAQRGKADGVSAINTVQGLMSLRADGSPWPAVGAAKATTYGGVSGNATRPQALRAVSLIANKLPGFPICGIGGIDSADVALQFLQCGAPILQICSSVQNQDFTVIEDYVLGLKALLYLRANPPPEALPWDGQSPPTAKLQKGKPVAPLRGADGKPLLHFGQYKKEREEKLAQLRQQHGALWDPCSEEQKATNGTNGHSAATTTAPVPKVKDVLGLALPRIGDYKKLDNSKQVVALIDDDLCINCGKCYMTCADSGYQAIEFDPVTHLPHVNDDCTGCNLCLSVCPIIDCISMVPKQIPHVIKRGHPGKVPVAVHALSPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQR2</accession>
    <name>A0A084WQR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">DNA polymerase II small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020799</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525397">
        <property type="protein sequence ID" value="KFB52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020799-RA">
        <property type="protein sequence ID" value="ASIC020799-PA"/>
        <property type="gene ID" value="ASIC020799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020799"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020799-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6724" checksum="8208EBF0C980525D" modified="2014-10-29" version="1">MSRQESGKSAKRRKAPPYGGRSTRQPAAEKRKSERVLAMGHALNLGVGFDRGERRRSPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WR99</accession>
    <name>A0A084WR99_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021006</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525404">
        <property type="protein sequence ID" value="KFB52743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WR99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021006-RA">
        <property type="protein sequence ID" value="ASIC021006-PA"/>
        <property type="gene ID" value="ASIC021006"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021006"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006390"/>
    <dbReference type="OrthoDB" id="10534299at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021006-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="371" mass="36747" checksum="35AA380EFBB27D68" modified="2014-10-29" version="1">MRIIVKAIAYTPGQPPSSGSIAFFELKAPRSLPAYPWYERERPGISGSPCLVLSFKTVHGAGHSGCAGVANDGSTAKPMINEPGSHESNSAKCHTMTNRNPGPNAPSRIFYEDYTRPEGGSERSRSNGSVSSSAASHQSSSSCVSVNSATSSTSVSSASAAADAVNANVLSVIGGRASSGGWVLEREPNPATGCIDSAPAPSPGSVADCCVRVSPLGGASASAVSVTSQQVASVPASVGGFSTKGGSSGCGGGSVGSANIGVSGLQRRVQEVQPCVADGGGGIDDQANGPLLLCPPVVASSAARTQTRQSSPSTASGVPFAVASTVGTGPGQISSTLTPAGSSNNEELGLPLSPDLLAKFLIEEASSGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WST1</accession>
    <name>A0A084WST1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003441-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00021579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026711">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525417">
        <property type="protein sequence ID" value="KFB53275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WST1"/>
    <dbReference type="STRING" id="74873.A0A084WST1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021579-RA">
        <property type="protein sequence ID" value="ASIC021579-PA"/>
        <property type="gene ID" value="ASIC021579"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021579"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017973"/>
    <dbReference type="OMA" id="YIQVQAM"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB53275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021579-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="583" mass="65791" checksum="FCCE2B0A516FD331" modified="2014-10-29" version="1">MLPVACLMFQSKAHLLRLVIVQHFFFCIPIAVLAGSLATMNGTDYLLIARCRSNCTYDKQCNNKCVQNYLENSAYKKYGDCPPKPPSKLDSLCLNTCDGLDYKCPGVERCCEHSCGQSCQTPHGLDKVKGLPPVPFHVLLLEKGRNYRTAQIQWEMKLEEEPSPTYYVVESRFHIGTTYAEHRMENDWQLHMPGSFIQDNLGTLKRYIGELKLKPGRWYQVRVAAVNEMGTRGYSAHSRPFQLSKSKHRAGGKMEKHSLYHGFFHVAGPNPPQPPKSLTVGPLVLNENRTYNCRVSWNLSKSDLPVEKYKLSWSLYLNYTSNRSKTDNSSLFKEMATITAVSLGAGIWPKITFDHRLDCYTLPQQPTRHYDIQGLLPNRYYYLQIQAISVYGKRRLKSAANHLLVNTSTPPGHDGAVNLDNLLMGDAAYRRPKAHPGLKDGSQQLTGTVIGGGRVGTAGIPTGTIRHQFVLRKAGLAVRLSWSEKGFGRYRVHICRGNRDCLMTASRGNGTQYWHDVVLRRNTYEFGKLEFDTRYTVGVRIGGHRRGPGYDIVRTFGTPKCEQIRSEELANVQPANLPPECNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTA8</accession>
    <name>A0A084WTA8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Helicase mot1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021957</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021957-RA">
        <property type="protein sequence ID" value="ASIC021957-PA"/>
        <property type="gene ID" value="ASIC021957"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021957"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021957-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="13475" checksum="E0D8C333723CA75B" modified="2014-10-29" version="1">MNPDVVRFIIFSESGPPAAHHGPAEPSVATVAWLVACPVGSRMPGRQQNSRTRVNMGGGGGDEKEVNVKPFAAVLIFPSRKGGNSMQTQRSEVHFYDGQPKGQPKKGCKYAGNPDRRRQTGFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU38</accession>
    <name>A0A084WU38_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00022111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU38"/>
    <dbReference type="STRING" id="74873.A0A084WU38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022111-RA">
        <property type="protein sequence ID" value="ASIC022111-PA"/>
        <property type="gene ID" value="ASIC022111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022111"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006129"/>
    <dbReference type="OMA" id="PRDYWKN"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02952">
        <property type="entry name" value="TRP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000124">
        <property type="entry name" value="Thioredoxin domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022111-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14278" checksum="321B46826C53F848" modified="2014-10-29" version="1">MVVKHKVTGYEEFTKLAESLESSGEPVHILFTGSKDENGESWCPYCVKAAPVVTKALESAPEKSHFITVEIERPFWKDQNCPYRKDPRTHLVFLPTLLRWRSPQRLDGSQCANADLVDMLLQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUH0</accession>
    <name>A0A084WUH0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00022306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01027083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUH0"/>
    <dbReference type="STRING" id="74873.A0A084WUH0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022306-RA">
        <property type="protein sequence ID" value="ASIC022306-PA"/>
        <property type="gene ID" value="ASIC022306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022306"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023285"/>
    <dbReference type="OMA" id="HIKLAMQ"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010751464" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="60"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="103"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB53864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022306-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="258" mass="28746" checksum="DEF221D9E1724C0C" modified="2014-10-29" version="1">MFHWHVAGVAVLVLVLVVPRVAPGPLERHRLPVPADELGDNFEGDILLTEEQSVQLRKRTGMYLPTFLWPDRTVPYEIVTGDFSPEHRSAIEAAIRTIEAFTCIRFVPATASTVDFVRIGAGQGCSSFVGRIRGAQQLTLQADPVGSGCFRHGTIVHELIHALGFYHMQSATDRDDWVSIQWENIEPGREGNFQSYGTDRILNYGVAYDYGSIMHYDERAFSTNGLPTIIPRADGVVIGQRLAMSPGDIQRILNMYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUQ2</accession>
    <name>A0A084WUQ2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00022193</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUQ2"/>
    <dbReference type="STRING" id="74873.A0A084WUQ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022193-RA">
        <property type="protein sequence ID" value="ASIC022193-PA"/>
        <property type="gene ID" value="ASIC022193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022193"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005967"/>
    <dbReference type="OMA" id="CESGLIN"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB53946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022193-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="618" mass="69235" checksum="C3154BE8D2848A72" modified="2014-10-29" version="1">MENRAYVGDCEVNATSPGYGTTNTGNSQIRVTTWEAQRTESGLPPREKWSKNIEFLLSCVALSVGFGNVWRFPYTAYKNGGGAFVIPYLIVLFIIGRPIYYLEMVMGQFSNRGCVKVYDLAPAMRGIGVGQTIAIFTVLTYYTSVLAITLRYLVASFSPELPWSKCDPGWTNCVDSNFKGNFSFNANITQPSTSAELFFKKTVLHATTTLNNGLGYPDWKLTLCLIVAWICIIAILIKGIKSSGKASYFLAIFPYIIIAVLLVRSLTLEGAWIGITYLFRPQWDKLLTIGIWYEAVTQCFFSLSICFGAQIVYSSFNNFSNNIYKHALIITSLDTITSLIAGCVVFGVIGHLAHVTGQTDMSKVVQGGAALTFITYPDTIAKFDFIPQFFSVLFFFMLFLLGIGTLIGIVTSVITAIHDQRPDITRWKIVIGVGLTGFAIGLIYITPGGLIVLDVLDYYGVTLVTLTLAVFELFTFAWIYGVNRICKDIEFMLDIKTGKFWRVCWGILTPITLLFILLISLYRYKAQDVPFGYNAFGWCLYSLAVLQVPCWAVYSVLQNGHGLFLFDRVKAVFQPNGSWGPEDPVTRTNYSQYIEQYKRQTIEQSSTRMRKLINVVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUZ6</accession>
    <name>A0A084WUZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001253</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL642708">
        <property type="protein sequence ID" value="KFB54040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001253-RA">
        <property type="protein sequence ID" value="ASIC001253-PA"/>
        <property type="gene ID" value="ASIC001253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001253"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009436"/>
    <dbReference type="OMA" id="CLLEQSC"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB54040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001253-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="90" mass="10075" checksum="59452DCE2B2B41B9" modified="2014-10-29" version="1">MDQFDDSFALEADGVQSLTPRKSPHLRRRGSLTHLNKILKPSSVTGFGFSGALGLTGAVSRKKISSMRKRMMNTMRKVMPMGRRTGYKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAP5</accession>
    <name>A0A084VAP5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002503-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00000859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01004135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524190">
        <property type="protein sequence ID" value="KFB35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAP5"/>
    <dbReference type="STRING" id="74873.A0A084VAP5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000859-RA">
        <property type="protein sequence ID" value="ASIC000859-PA"/>
        <property type="gene ID" value="ASIC000859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000859"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002586"/>
    <dbReference type="OMA" id="THICEED"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF394">
        <property type="entry name" value="LUCIFERIN 4-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000859-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="231" mass="25541" checksum="0929B7FFBC26420B" modified="2014-10-29" version="1">MFIFIPDDYIQCLAEFRPQFLFVVPSLLLFLATHPKVTPDLLSSVESVLVGAAPASLQLQEKFRHKVGRDIDIAQGYGMTESSPVTLCTPFRYDQTKVGTCGLLYPNTEAKIVSLTDGSNLGPHQSGELYIRGPQVMKGYLNNEAATKETLVEGGFLRTGDVAYYDKDGYFFIVDRTKELIKVKGNQVRTHDASVLLFLPSYLYLFVIVKKRIDPLKLALIQIVTGGGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBJ6</accession>
    <name>A0A084VBJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP003568-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00001736</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01007649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524424">
        <property type="protein sequence ID" value="KFB35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBJ6"/>
    <dbReference type="STRING" id="74873.A0A084VBJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001736-RA">
        <property type="protein sequence ID" value="ASIC001736-PA"/>
        <property type="gene ID" value="ASIC001736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001736"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010520"/>
    <dbReference type="OMA" id="GTSANMD"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783190" evidence="5">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19817" checksum="72AFC23F9FFD182A" modified="2014-10-29" version="1">MLPATVIIVVVVFAVLLVVPPTSAAGSGSSSSSNSNSNSNSMDENETLKKATSSRIVHTKYGSVSGTIEHLDGRHLDPVEAFRGIPYASPPVGNLRFMPRFSPVCPQRLPDIYNETAALERMPRGRLEYLRRLLPYLRNQSEDCLYLNIYVPTQGLHNRKQKRKPQPFQRNPLTITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBL6</accession>
    <name>A0A084VBL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001856</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524458">
        <property type="protein sequence ID" value="KFB35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBL6"/>
    <dbReference type="STRING" id="74873.A0A084VBL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001856-RA">
        <property type="protein sequence ID" value="ASIC001856-PA"/>
        <property type="gene ID" value="ASIC001856"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001856"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023030"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001856-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="9897" checksum="9094B7EE04205891" modified="2014-10-29" version="1">MSTTSISREEERKPLMEEFYRQRRILLGCTVLIGVAAFIWIVAISTDHWFVVTGGQAPQAINRNRPNSASVQLVRRNEPNDCANRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBM4</accession>
    <name>A0A084VBM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524462">
        <property type="protein sequence ID" value="KFB35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001879-RA">
        <property type="protein sequence ID" value="ASIC001879-PA"/>
        <property type="gene ID" value="ASIC001879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001879"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9248" checksum="15B311CF71886043" modified="2014-10-29" version="1">MMNDGGPGRHHHTSTLPLRKPPPPAQKADTAQTEFTSASYSRPCVHVIPLPWGKVLLSHAGTGRTKPLSHKEEEERCRFVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCW2</accession>
    <name>A0A084VCW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524624">
        <property type="protein sequence ID" value="KFB35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002730-RA">
        <property type="protein sequence ID" value="ASIC002730-PA"/>
        <property type="gene ID" value="ASIC002730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002730"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="8957" checksum="EC2598BBF7A270E3" modified="2014-10-29" version="1">MLTATIAASTWTNVNRMRLSGMQMCLHARSLARCVPEGPVERVAPSPGFANGLSVYELCIAAPIAGLGDFGVVATGYTVPGRVYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDW6</accession>
    <name>A0A084VDW6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524724">
        <property type="protein sequence ID" value="KFB36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDW6"/>
    <dbReference type="STRING" id="74873.A0A084VDW6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003220-RA">
        <property type="protein sequence ID" value="ASIC003220-PA"/>
        <property type="gene ID" value="ASIC003220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003220"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023476"/>
    <dbReference type="OrthoDB" id="9942256at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003220-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6332" checksum="228398677BD8B119" modified="2014-10-29" version="1">MEVDDLFIDLADGIKLLKLLEIISGEKLGKPNSGRMRVHKIENVNKSLAFLHTKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEA1</accession>
    <name>A0A084VEA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003416</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524775">
        <property type="protein sequence ID" value="KFB36295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003416-RA">
        <property type="protein sequence ID" value="ASIC003416-PA"/>
        <property type="gene ID" value="ASIC003416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003416"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="270" mass="29485" checksum="D1908DA85A333C60" modified="2014-10-29" version="1">MGHQPNRYLCQCGATRWHFVQPFSGEAADCASSWVVFFLAVQENGRKGFQKSPFPLGDWILAGKKIKKSRESAPKAVGIEEQKSCSVEILCESPCPTTLTWACACLLCSVGPCVRRVRCVSVRKRERIGVGDYFSVRSPSHIPITGAVVPKDTYLPQKHTHTRGGVWAGEFSRRKQPSFGSVRCNCLLPTADSSSRSVNDVGSSESTPTDMDYVEHNDGSLLLVRGLMGSVTSEPPWAVTVRAFVRAPVPTPSWLRAAIGTVQHSGVCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFD6</accession>
    <name>A0A084VFD6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP007879-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00003841</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012377">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524786">
        <property type="protein sequence ID" value="KFB36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFD6"/>
    <dbReference type="STRING" id="74873.A0A084VFD6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003841-RA">
        <property type="protein sequence ID" value="ASIC003841-PA"/>
        <property type="gene ID" value="ASIC003841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003841"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003323"/>
    <dbReference type="OMA" id="ININCMA"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003841-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="244" mass="27151" checksum="1E055F1AB48B7F57" modified="2014-10-29" version="1">MPVVLVARNESKLKQVADEIKTEYGVETKVVVADFSHGREIYDHLEKSLLPLDIGILVNNVGVTYERPKPVYDLSKEELWNLINVNVAPTTLLCTMLAPAMKQRGRGLIVNISSMTSVCPMPYLTAYSATKAYVTTFSMALREELKPFNVEVQTVLPGVVHTNMTKFIASGLRDTIYSKFLVSVDGYLAYAGRTLGKLDRTTGHWSHGLQTAGMYLLPEFLRIYVSGKLNKAMGEELNASSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFF2</accession>
    <name>A0A084VFF2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00003845</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524787">
        <property type="protein sequence ID" value="KFB36696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFF2"/>
    <dbReference type="STRING" id="74873.A0A084VFF2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003845-RA">
        <property type="protein sequence ID" value="ASIC003845-PA"/>
        <property type="gene ID" value="ASIC003845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003845"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000960"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000001">
        <property type="entry name" value="Putative cop9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="256"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB36696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003845-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="445" mass="51589" checksum="4839ADE41D5A57E6" modified="2014-10-29" version="1">MSDIDDDFMCDDDDDDYGLEYSEDSNSEPDVDLENQYYNSKALKEEAPQEALKSFQKVLDLENGEKGEWGFKALKQMIKLNFKLQNYQEMMSRYKQLLTYIKSAVTRNHSEKSINSILDYISTSKNMELLQNFYETTLEALKDAKNDRLWFKTNTKLGKLYFDRNDFGKLQKILKQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTVQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSSRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVTAYQTNDIMEFESILRNNRNNIMADQFIREHIEDLLRNIRTQVLIKLIRPYTRITIPFISNELNIEPAEVESLLVSCILDNTIQGRIDQVNQVLELSKESRCGARDVAIEKWANQISSVQAAIINKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFN5</accession>
    <name>A0A084VFN5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP000562-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00003938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFN5"/>
    <dbReference type="STRING" id="74873.A0A084VFN5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003938-RA">
        <property type="protein sequence ID" value="ASIC003938-PA"/>
        <property type="gene ID" value="ASIC003938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003938"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012762"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12679" checksum="FF3CB2EECA598F0F" modified="2014-10-29" version="1">MNVRVTTMDAELEFAIQQGTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDNTWIKLYKKVDTISIEVAFEVNLGCRLDGVNRVSMDNNRTKREGKESVFQPAKRLSKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFP0</accession>
    <name>A0A084VFP0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003944</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFP0"/>
    <dbReference type="STRING" id="74873.A0A084VFP0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003944-RA">
        <property type="protein sequence ID" value="ASIC003944-PA"/>
        <property type="gene ID" value="ASIC003944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003944"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001592"/>
    <dbReference type="OMA" id="TMHATVR"/>
    <dbReference type="OrthoDB" id="6479909at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF11">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="225"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003944-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="508" mass="56954" checksum="03B5F6827A2355C5" modified="2014-10-29" version="1">MPSLWIVWIIFQEYGYASSTSGKAHESLLSSAPEMINLCRTMKSDRHGTSNRTILAKDNQLEAVQDILHPEPVPFTVYQPSPTIKHQHQLQYIDYKLHYGLRYNPRYDGSKANVQRHPSSKNTSSWNATKVSLPALGVSPIRERNKLIPPKQYETPAVPLLSVINIITFVNGPCVPRRNAPGNTSSVVSWMGICYHEKECSQLKGIPMDTCAGGFGVCCVFQYGCDSRSEQNVSYFLSPSFPSPAVEPLPCTFTLALHRSVRQVVLEFVFFELQPPQLGNCIEDQFVVSIQNDHRIYPVLCGVNSGQHMYLDIDRAYSHLVFLNAVFSSRQPRAFLVKITQLSTPRAPMNCLQFHDGLSGIVKSFNYDNYSTVVKHRKASYLNNLNYAICIKRHIMFCNVVFTNENALGKENIFQLVNIAEDGSSLVPPNQAGVEIFSCPDDYIAINYMRLCGERLNDGSVVADFTRNTPVSYTSAGPILIAVRSDESIVGRGFKLTYKQNVCIDKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG95</accession>
    <name>A0A084VG95_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Recombination activator protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004181</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524812">
        <property type="protein sequence ID" value="KFB36989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004181-RA">
        <property type="protein sequence ID" value="ASIC004181-PA"/>
        <property type="gene ID" value="ASIC004181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004181"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004181-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="15335" checksum="F25146B934711EC3" modified="2014-10-29" version="1">MNAYRFPSSSQLPLLIDVPEAQYVHSTVYARAETGLEVRKRDSSDGIVLGVRRLIPSLARGVRKADCRQARNAGEDDREDHRSRNLLGGKLYLKTTLRSLHQSVVPFPFPPPQNRCPVRAGRVGIGSATRPSRRPACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI61</accession>
    <name>A0A084VI61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP001591-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00004911</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524850">
        <property type="protein sequence ID" value="KFB37655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VI61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004911-RA">
        <property type="protein sequence ID" value="ASIC004911-PA"/>
        <property type="gene ID" value="ASIC004911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004911"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001142"/>
    <dbReference type="OMA" id="DQGKNGT"/>
    <dbReference type="OrthoDB" id="6510378at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000345">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000347">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000306">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000382">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000124">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056989">
        <property type="entry name" value="PCDH15_12th_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23206">
        <property type="entry name" value="PCDH15_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1714"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="274"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="379"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="495"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="587"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="701"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="817"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="939"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1043"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1162"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1263"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1396"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="1493"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB37655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004911-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1857" mass="207341" checksum="D3EB22BD51B03122" modified="2014-10-29" version="1">MSQNHTSKPSKNEIILRAANRLKWDLWILLILCWCVGLTTANRAPVFLIDDHAEIVIRLKEFPETPVGTLIYRLRGFDADGDPLTFGVQKSADSHIIRLTQNKSTEAYIFLNHELDREARDEYTLILTLTDGRLGEGNFVTQSFLLLVEDINDNEPIFRPFASVLEVPEDSPPGILTTLEAVDRDEGAYGQVVYYIQGPREEDNVFSVATVNGKGVVRLARGLDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQPPEFLVTQPVVRIAEDAPIGSEVLRVKAVDGDRGINNRIRYGIANNASELFEIDRYKGSLRTRRKLDREDPGNPINGAFILEVVATEESKLKPPPSASMEITVIVTDVNDEVPRFRSESYECEIGENAQENTLATFLEGSMNEVFDYDQGKNGTFRLSLQPPSDIFEVIPKKAINEATFGVRVRKSALLDYERLRQVNLTLVASEVEMGGRSSTAQLRILIRDQNDNFPEFSRPVYEVDVPENVTMGTVLVRVEATDIDSGEFGTAGIRYTNLTGDDSPTFDREIVPVHYLSVEARDNGGRGNRNTVQLVLNLLDVNDHAPVFVQKQYEVRLRENAFEFESPIAVEARDLDQEGTPNSAVEYRLLGSVHSEHFLVDRRTGRLSVREAVDFERLEGGQSDTRPIALTVEARDGGEPQQSAQVTVTVFVQDVNDHAPVFLEAQYSLTVPEDTPANLPILRVVAMDSDGSFPNNLVSYRIQQGADGRFVIGAETGEISVASGASLDPNLLSPDEMNDGSSFVLEVIATDGGNGDQQLQGSCLVNVTVTDVNNKPPYFIGPTSVAVRENTPVGTEVYRLLAADPDEGAMLRYYIDRSQSEGKTEEGALVKLDDYDFVAAFVLNETNGLLKIAKLLDREKISDIKLACVVEDVAAERGDQMATTVLRVTILDENDNNPKFRKPFYKHSIAENSQFGVPVCTVVAEDADLNKTIRYNLEGEPAVLELLHVDEQTGELVVRNRIDHEEFGWLNFSVRAVDSGVPPRASFVEVFVQVLDENDNNPYFVDGISDFYVAENASIGTEIAAILAKDLDSGDFGRITYILDRISSKEKFSIDPEKGVLRVAGPLDREDTDEYMMAVEAWDNYPYGYLNGESRNAFKHILVHVTDVNDNVPVLQKPTGCSMVTEYHNINEPIVKLRATDADDPVDGNGQVSFDINDASGIFYIQQSTAHSAEVYARGPLKNLYGNYTLEVLVSDLGAVPNTVRDTVEICVADFNDHAPVFVVPNGNATVKVFENITIGKPFFQVHAYDEDVGENAIVRYRLKMDSAGNYRKFAIDKDTGEISVASPLDRELQNVYDLRIEAYDQGVPTPLSSSVDLMVYVRDVNDNQPQFLLKEISLNFTEHTMTGVERIRLPDTVDHDYLDPLEGPSSTVCYYIVQGNEDGHFALDPFSHELTVDKELDRETKSRYKLHIKASEDCTNLNSSSHSDPISNGGNLLKVTIYVNDINDNSPVFESQIFTGGISTSSQFGSTILQLKANDADDGPNGFVRYYRHGEIRKTLAEGLDELRSDPFLVDTETGKVLLNFFPQKSMRGYFDFSVTANDSYGCHDRAHVFIYLIREDQRVKFILRQRPSEIRQNINSFREILSNVSGCIVNIDDIRLHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLEKHVEKLDRLFKEFNVLDTQASELIQTAEMDELSVNIIWLFVTNLILGSLLIVVIGVSVSSRLSYRRRLRAAKIAAYGKHHMLXXXXXXXXNPIWISDNDGDWPRDEFDKCKDAIDAQYERSLSSGFFIDNCQLQYDGRRGAGTGGSGGPEANNAANYRIKKGNDESTLCVARNLETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI97</accession>
    <name>A0A084VI97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005016</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI97"/>
    <dbReference type="STRING" id="74873.A0A084VI97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005016-RA">
        <property type="protein sequence ID" value="ASIC005016-PA"/>
        <property type="gene ID" value="ASIC005016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005016"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8390" checksum="E20A44D074AB8656" modified="2014-10-29" version="1">MRSAAQSSSMDSVTKRLFDLLAAAENSRTPSNDSSQSSSNLLSSLVSASGGAANASSTTQQQFLKDVLVQFAKMSQNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIG0</accession>
    <name>A0A084VIG0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP011686-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00005068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524854">
        <property type="protein sequence ID" value="KFB37754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIG0"/>
    <dbReference type="STRING" id="74873.A0A084VIG0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005068-RA">
        <property type="protein sequence ID" value="ASIC005068-PA"/>
        <property type="gene ID" value="ASIC005068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005068"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003429"/>
    <dbReference type="OMA" id="TGFNYGM"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18305">
        <property type="entry name" value="BTB_POZ_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB37754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005068-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="549" mass="62245" checksum="EF9CE67E3308FBFD" modified="2014-10-29" version="1">MGNVLNKLSDVSQSVRGRKRKREADDGGESGVGSDLLDKSLQTPKRKKLTSTAKYIYQALFKEERNSDITVHALGRQWHLHKVYLSQSPYFASMFNGSWREADDDYVHIEIIDPKITISSLYSVFGSLYMDEIVLEPKEVISTLATATLFQLDSLIDRCAEVMVETINAETAVLYYEAACEYGVKVVKQTTYSWLLVNLLSVYFRAAKWLRIISPELMEQLISNPDLYVVQTEFSLYQLIRFWMSLKLFPDVEPTIEPGKNPGIDDPIVRYFAERTSTVPFLCTSEGAPFEQVFRALRLRHLLNHHVDIKILRQDNIIPIEWLHKPLFQQWNSVLMIDQSLDRQIECDDRTFLESCIRCARILEKNESSKWRWTGFHYGLDLLLISDTRTLRIKRHHRTENERLLSLQVKRQFLIRISLTSMNELGQIKHQQTTQIVSVSLEKNEEAPLVVFDPELTYPMLISVNMMLDSPPVKVAPNLPALSDASGTTDPTPGPTGDTLAQNPSSSQASTSPSIARRLIAPGSSGNVTVESLDGSAGSSNRMALVNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK21</accession>
    <name>A0A084VK21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP002842-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00005664</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014049">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524932">
        <property type="protein sequence ID" value="KFB38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK21"/>
    <dbReference type="STRING" id="74873.A0A084VK21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005664-RA">
        <property type="protein sequence ID" value="ASIC005664-PA"/>
        <property type="gene ID" value="ASIC005664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005664"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003962"/>
    <dbReference type="OMA" id="GYEWFCG"/>
    <dbReference type="OrthoDB" id="6357057at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783754" evidence="10">
        <location>
            <begin position="29"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005664-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="303" mass="32627" checksum="FDBE97E4950C8218" modified="2014-10-29" version="1">MGSLRSTSSARLLVCLTICFELLTAVGAVIGGDNAPVGEFPHMALLGRPCSQPLRYSFTSDTGDCTEYDWFCGGSLISNRFVLTAAHCAHTEMQNPPTVVRLGEYDLNDGTEVPHQDFEVRAIVHHPGYNGIQTYNDIALVELDRTVTFSRFIQPACLWPHDTIPDEAPLIATGWGKVGHYDEPATILQCVGIPIVSNSRCNRLMMNLINRRLRNGILPSQLCAGDPLGGKDTCEGDSGGPLQLVTPHEEGTPEAGLCRYQIVGVTSNGGICGSANRPGIYTRVSAYVGWIEGVVWGKTPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKV7</accession>
    <name>A0A084VKV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">YALI0B11286p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005977</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKV7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005977-RA">
        <property type="protein sequence ID" value="ASIC005977-PA"/>
        <property type="gene ID" value="ASIC005977"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005977"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005977-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10048" checksum="4687FDDB59B1570C" modified="2014-10-29" version="1">MYEFYVRVHHGGAQRRTSSSSSARLMSVALNMLFTLEKPPSHILGRKKAAPEDNNTAKTGENFRNGQRDPPLASVGTILIEDRPDPGQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLJ3</accession>
    <name>A0A084VLJ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006323</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLJ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006323-RA">
        <property type="protein sequence ID" value="ASIC006323-PA"/>
        <property type="gene ID" value="ASIC006323"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006323"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006323-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6530" checksum="E5EB5A1FA62ED523" modified="2014-10-29" version="1">MYLASTHGLAEADNICFHNPGMPNGLFCFATSTRNAFVREAAEKCHSTEARGCQRDPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLN4</accession>
    <name>A0A084VLN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000234-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006369</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084VLN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006369-RA">
        <property type="protein sequence ID" value="ASIC006369-PA"/>
        <property type="gene ID" value="ASIC006369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006369"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010050"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006369-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="168" mass="19653" checksum="80396ABA569EA45B" modified="2014-10-29" version="1">MPPSRVRLVSWQDLCDQTDLCWLATTTTTTASPYAAYIELELWTVKRFDLQYPFDNLSRYLLTHPGDGTAQESVTTSAGAVQSERPEPSWTLPEAVDRLPPAERDLLQRLLQPVPEKRLRSLLQLQRIAIYQHYRWDDVRNFKMKPQSYIQHSTLDYETTQEMFSDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLS3</accession>
    <name>A0A084VLS3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006238</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLS3"/>
    <dbReference type="STRING" id="74873.A0A084VLS3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006238-RA">
        <property type="protein sequence ID" value="ASIC006238-PA"/>
        <property type="gene ID" value="ASIC006238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006238"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001454"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006238-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="368" mass="38677" checksum="58F126CFA675AE37" modified="2014-10-29" version="1">MNFVEHGPSSRQQGGVPSGAAGGAGALAKGSTDSFPSQDSGDNVPACPSAGSSQSHSRHASCLEAGTNELCDLVGGSGVGQNAHGHHRDATGMVCKLCCSTGDLRPPHRKDLPALHKSLETCCHVNFLHAVEPVRQLANLAADSEDSIVVGTRKVCTVGLPATSGVSSAGSNVSSLVNLDATGSPPRATSPTAEVRELLEQIRQLHNDEDHDDPGVGVPQSSVSSGVPTFSAYRRPSSLIGRRRKLFSKSSSQYPPPPQHHQHHQHQQQQQQQQHHYQHNKAVYTPIGFAQNCMPPTASGMRHLRSPASSSGGGASGFLNRGRSRYCWMSKSAPTTPGAAPGSFAGGTLGDNRPLLLHEQEEDGEQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMC9</accession>
    <name>A0A084VMC9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014585">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMC9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006452-RA">
        <property type="protein sequence ID" value="ASIC006452-PA"/>
        <property type="gene ID" value="ASIC006452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006452"/>
    <dbReference type="OrthoDB" id="6361509at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006452-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="280" mass="28383" checksum="47788EC67E02AE3B" modified="2014-10-29" version="1">MVPHRGGVSTATPLPHGTSFRTAQAYATTIQPQATADGVNYIYHPAAVVAATASAGTNVPSNSTISFLPAQPPPLPPSSTVASTQTASLPSVRSSPSPAAATHVGLLQQSKGGGSAGMYGGGSATLPYTSVAPSCYNCGSLKHTGLECPEASMEDMTRTTNFTLDYNTTSTVTPVTTPTTTSAPAIGGNNNTATLDTNINSFLVDEQYARAGAGCCDRCEWRGGPSSAGSNITNSTNNLVSASVASAVAAASVAAATAAVYRSFFRSLFSLSSSTNQQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN49</accession>
    <name>A0A084VN49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Mannonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006820</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006820-RA">
        <property type="protein sequence ID" value="ASIC006820-PA"/>
        <property type="gene ID" value="ASIC006820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006820"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="209" mass="22973" checksum="7FB9DD268768035A" modified="2014-10-29" version="1">MSLAPHSTGGPPSLKSSAEKWAEPTGIDCCPRPSSRRPGTEAGAWLHCTFLRANLRSGRAVRRKWPNWLAWRPQGFAVLASTKPTVQIFRQRHSLASVEAEPPRFRVSAFGIPGRPASRLNASRCSDHAGRSGCASRVASGTESERVPNPRYYAQIFDKLNYRHRRWSGQLDNAATDCQATSLHRIVELSRSILGRDASDSASGLVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNA3</accession>
    <name>A0A084VNA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Protein export cytoplasm protein SecA ATPase RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006938</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006938-RA">
        <property type="protein sequence ID" value="ASIC006938-PA"/>
        <property type="gene ID" value="ASIC006938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006938"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="16625" checksum="F9B0E753654A62C6" modified="2014-10-29" version="1">MSSSSSHAILPFAALFAQDDDSEPGVVWFEGENAYFETLSDVMVPGHKCLHGVGLGQTVFQDVEFPITIPIVYEPSATSMLPPREACKDSIADGRVDRANDGSTVAYRGLCSDKPPLVKRNQAVSYEFCEESQMKDFFRRRSGGFLLPVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNR6</accession>
    <name>A0A084VNR6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP004199-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007050</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524991">
        <property type="protein sequence ID" value="KFB39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNR6"/>
    <dbReference type="STRING" id="74873.A0A084VNR6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007050-RA">
        <property type="protein sequence ID" value="ASIC007050-PA"/>
        <property type="gene ID" value="ASIC007050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007050"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016147"/>
    <dbReference type="OMA" id="WNIAHRN"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007050-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="501" mass="55043" checksum="28BC98C5C73DE70F" modified="2014-10-29" version="1">MASSFGVWDYVVFIAMLIVSAGIGVYYRFSGGKQKTTTYLEKRFGKKTRLAASLAYTLQMILYMGIAVYAPALALQAVTGLDQAYSILAIGGICTFYSTIGGMKAVLFTDVFQSVLMFAAIYAVIICAAVKAGGLSPIWDAASEGGRLEIWNFNPDPTTRHTWWSLTIGGMFTYLSLYAVNQTQVQRLKTVKDLKSAQKALWLNWPILSLLSLSTSFSGLAIYYFYRTCDPLQQGRIKVRDQTMPLFVVDAMGDLPGLPGLFVSGIFSASLSTVSAALNSLAAVTLEDYLKPFFPSKVMAFVYGLICIAVAFLAQNMGGVLQASLTIFGVVGGPLFALFSMGMFTTRANQRGVITGLLTGLSFSLWVGFGQPRPPLKTLEFSVDDCSEFGGFNQTSVVPLAMAQRAADVRPDSDYFYLYRLSYMWFSVLGYLVTFAVGYGTSLLLRWRGMAGTERIYLDEQQVYLNTDLFSPPVARAMKQRMARFIENGGDVRMTSLEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPM1</accession>
    <name>A0A084VPM1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Oligopeptide transporter 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007295</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPM1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007295-RA">
        <property type="protein sequence ID" value="ASIC007295-PA"/>
        <property type="gene ID" value="ASIC007295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007295"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007295-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10773" checksum="0A0BCC2CBA9E5372" modified="2014-10-29" version="1">MNNFRQLVENFGPRNRSFDARWKTRCGTQTQARRPEDSAGKMLQLLHSAAVLQSRRKNSAAVKKKASKKQKPRWTMRNKENQYRTGHSRAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRA8</accession>
    <name>A0A084VRA8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007994</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525023">
        <property type="protein sequence ID" value="KFB40502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRA8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007994-RA">
        <property type="protein sequence ID" value="ASIC007994-PA"/>
        <property type="gene ID" value="ASIC007994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007994"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="13591" checksum="B197B7A727544059" modified="2014-10-29" version="1">MRYLTVRPLAHIWSVGCASTDFGTAPQNGNDDEDDDRTRHYLDRCRTLARVKCEKKESEEFLHLRMVAGKPKSRSSSLVSPPSAETNCINIPRRGSATGDLVRFCVQNENAACGEHRWNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRZ9</accession>
    <name>A0A084VRZ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein male-specific lethal-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00008170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRZ9"/>
    <dbReference type="STRING" id="74873.A0A084VRZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008170-RA">
        <property type="protein sequence ID" value="ASIC008170-PA"/>
        <property type="gene ID" value="ASIC008170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008170"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011426"/>
    <dbReference type="OMA" id="YKGTPDK"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000042">
        <property type="entry name" value="male-specific lethal 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="12">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="11">
        <location>
            <begin position="159"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB40743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008170-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="495" mass="57178" checksum="C526B89FCA4E6F1C" modified="2014-10-29" version="1">MVSTRGHNTKYKFCDGEKVLCYEPDPTKAKVLYDSKVLEVSEGKDKRGRRIVEYLIHFQGWNSSWDRKVSEDFILKDTEENRQLQKDLAEKSQLYQGAYLYRKERKKQRAKSLTDRIESLTNAKTHHGSSEEGSSCSNGGFGRDDNDYNMDDMDEYYSSSVESTQEEEKVYLQAGTKFRKHLDLDQHLIFVENMWVELPAKLPVVTILEDFVRYYTIRQLFECGHQEQTKSRRRNSSALRSEQKLRDYEQIRTNVELCKEVADGLRVYFDFTLKDYLLYPQEKAQAEIVLAEENLSQFTYIASQNLSLDMLAVRLESPPTDLPVVGEHSEQSSVAASAEERRRRRLRSHKNEENEFVLDFAALQQQGSQSGQSQQSVAPESGGNLSPFGSSLNILRTVLPQNVTISREAKEVLDEVFRWRILPSNAPAEPSMIYGAIHLARLIVKLPEFLSATAMSDEKLKLLLKFLDIFAEFIEEHEEWFGKPFYFSARDSDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSM5</accession>
    <name>A0A084VSM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008651-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00008618</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSM5"/>
    <dbReference type="STRING" id="74873.A0A084VSM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008618-RA">
        <property type="protein sequence ID" value="ASIC008618-PA"/>
        <property type="gene ID" value="ASIC008618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008618"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008601"/>
    <dbReference type="OMA" id="GNWNYTA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000004">
        <property type="entry name" value="Cryptochrome-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="396"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008618-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="557" mass="63853" checksum="4FC076C1E053D5CA" modified="2014-10-29" version="1">MAKKETIVHWFRKGLRTHDNPALSVAVDRVRENPNKYFLRPIFVLDPGIRKWLRVGPNRWRFLQQTLANLDENLRLINSRLYVVRGNPIEVFPKLFEEWNVSLLTYEYDIEPYAVKRDKTVEEQATKHKVEVHVAKSHTIFDPELILKRNGGKPPLTYQKYASVSSVFKIPQALPVPEKLPANCVHPEADKQERKNPSCYDVPTLDELGIAGNELGECKFPGGETEALRRMEKCLARKAWICSFEKPNTSPNSLEPSTTVLSPYLKFGCLSARLFYNRISETIKGQKHSQPPVSLIGQLMWREFYYCAAAGTPNFDKMVGNNVCLQVDWDTNREFLDAWTHGRTGYPFIDACMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEELLLDADWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPEGKFIRKYVPEVARFPAGIIYEPWKASIETQKKLGCIIGKDYPNRIVVHEEISKVNIQRMSAAYKRNKGLKDEVTGDDSSAAQSKPTNKRGSTASSSSKSSPKAKPAPKRQKLENTIKKFLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUB3</accession>
    <name>A0A084VUB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004859-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009157</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUB3"/>
    <dbReference type="STRING" id="74873.A0A084VUB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009157-RA">
        <property type="protein sequence ID" value="ASIC009157-PA"/>
        <property type="gene ID" value="ASIC009157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009157"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002178"/>
    <dbReference type="OrthoDB" id="7727469at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009157-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="427" mass="47644" checksum="783EAB08FE905028" modified="2014-10-29" version="1">MRAFARGYTFNFIEGEMHEKSPFTLLDLLRQRKRWLQGILLVVRSPAIPLYNKFLLGINLCSWITLPLSSLNLVLTAIYPISCFELLDIVCAFITGVTIYMYLFGVFKSFSLLRFKPKFFLLCSVGVLCTIPVNIVIENIAVIWGLLGTVCRVRCMQSSCFDRGGKMRPFALLLFSLLYVFLTLHPHATIGQRSNAETSHIVLLGSTRADGTREFRCGGSYLGRNIVVAGAHCATGKNQPPLDTARFGAGTGNAVNLRIANHTLHYRYKPQFEYHNMAIFFLDRNPDSAMFKPACVLRPHIPRGTVQLVGDGSNGRGLSLQTTDLDVVPSDKCHEYYNPIPKLRFGVLLCCFCAMNANTKECSTLHSSPLQYTVTQNGKRVPFLIGHRSIGKACGVKSPAVYTRYGSYYEWLETVTNLPLDAAGKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUH6</accession>
    <name>A0A084VUH6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009238</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016819">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525118">
        <property type="protein sequence ID" value="KFB41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUH6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009238-RA">
        <property type="protein sequence ID" value="ASIC009238-PA"/>
        <property type="gene ID" value="ASIC009238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009238"/>
    <dbReference type="OrthoDB" id="7765073at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009238-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7428" checksum="EE5A033570C75B91" modified="2014-10-29" version="1">MYGRPEHLIDTLLGKIRRAPPLKEGRLDSLLDFAITVEEICATVRCSAAEHRFDGPVLRELVDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VX03</accession>
    <name>A0A084VX03_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00010210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="ATLV01017821">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525194">
        <property type="protein sequence ID" value="KFB42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VX03"/>
    <dbReference type="STRING" id="74873.A0A084VX03"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010210-RA">
        <property type="protein sequence ID" value="ASIC010210-PA"/>
        <property type="gene ID" value="ASIC010210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010210"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013191"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010210-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="233" mass="26800" checksum="5120162DEFA25E2F" modified="2014-10-29" version="1">MSFVDLASLRIKYKSEKEIFLESSIDRKEPISLFRKWLQEACETPEIIEPNAMCLATATKDAVPSARFVLLKDVTDDGFTFFTNYESRKADELAENPNVALAFYWLPLRRSVRIEGSAERISREASESYFHQRPRASQIGALASPQSKPIPNREFLDTKEKAIKEELGPDREVPLPNWGGYLVRPKAIEFWQGQTNRLHDRIRFRKELKAGDTVDGELLHQGENGWVYERLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXJ4</accession>
    <name>A0A084VXJ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative siderophore receptor IreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010425</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018078">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXJ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010425-RA">
        <property type="protein sequence ID" value="ASIC010425-PA"/>
        <property type="gene ID" value="ASIC010425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010425"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010425-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="194" mass="20900" checksum="362D36221E60C9EF" modified="2014-10-29" version="1">MHSMVVATEQHRKGSRRKDTTGNSVQCAQNSLKSLLHCDYFNIPATVGGASVTSDCAGSNQLLTAASTSTILPDERLVTANFSTHHGGGKRRCSRSSRRRDRAGRCNGGNGGSSILSLARMPCSRSIYTRITRPPTTPVGASDVTLARFRQPAIGSTTHHRSRTKRLQRCLVQTCLALFLILGCCDAAKQEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXZ4</accession>
    <name>A0A084VXZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018226">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010588-RA">
        <property type="protein sequence ID" value="ASIC010588-PA"/>
        <property type="gene ID" value="ASIC010588"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010588"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010588-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7505" checksum="1A6EAD6910F09391" modified="2014-10-29" version="1">MSALQSDKGHHYTSRFSRQPHQPDIDTGSRRSRATDVHSKNPTKGPPPSARKQMKEPPTEQNRAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYI8</accession>
    <name>A0A084VYI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC100711570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010706</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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</entry>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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</entry>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zou P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="620" mass="67301" checksum="0EA99FE239505C0B" modified="2014-10-29" version="1">MEPSTFDDQIFGDFTSETLGTLAGGAKPIHAGPSPTSVANAASGHGNLQVMMGIGHSPTHDGGGGGGGGQQQQQQHQRLPEVNSILAVAGSPSYKTVDYTNLSKVEYHHLANGKLDGPSSASYSPPAHQQHQQQHQQQHHHMVAAPNGKSIEYVNCKLEYYTALPIGHDNASKMEFVKTLDYNGNGRLDYSTSSSSSPNGSKVLDYGNGGPGAGKLDYETTIAMXXXXXXXQPGGQPVLVDAGSAMQKQRKADVDMNGASGSSTPTTTAASNASPLDGSGNGKKNDKKKTDPNGIKKKKTRTTFTAYQLEELEHAFERAPYPDVFAREELALKLNLSESRVQVWFQNRRAKWRKREPPRKSAYLGNNSPSAPLNGPIGTTFGQFPQTATVTPPGSVDSWSTYQAPYELGPHINLLSPAVSPYGSYSTQYGTYMPESHMFPVRQHFDYGSPSRAGGVGEPGADEPAAHQHQHQHQHHTHHGHHHASQQHQQQHQQHQQQHHKPDHYAPLDDKFDTHCTAGLPDGLTNGKYVDDTKYIHAVDVHYNPDADPKYGSCHQLDDPAMKAHYGPPQQTQQPSSQQQQTQQQQGQCQPVGVDDPDGLGLVKAEESVTHSYVLPSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZD2</accession>
    <name>A0A084VZD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003415-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00011118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZD2"/>
    <dbReference type="STRING" id="74873.A0A084VZD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011118-RA">
        <property type="protein sequence ID" value="ASIC011118-PA"/>
        <property type="gene ID" value="ASIC011118"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011118"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000202"/>
    <dbReference type="OMA" id="NGPRCGF"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011118-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="219" mass="24132" checksum="2BD371E3DD3ECF0F" modified="2014-10-29" version="1">MVITKVSTEEQYKQLIGAAGVSLVLFSAEWAEQCKQITDVMNELAKQPEFKAIQFLDVPAEDLSEVSLHHQIDSVPTVLFFRAGTALDRIDGVDVGSLTQKVKKYASAPASELSSSASANLEERLKALINRSKVMIFMKGDRNTPRCGFSKQLIAIVNDTGVEYDTFDILTDEAVRQGLKTFSNWPTYPQVYVNGELIGGLDIIKELLEGGELKETLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZH2</accession>
    <name>A0A084VZH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011162</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018804">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525248">
        <property type="protein sequence ID" value="KFB43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011162-RA">
        <property type="protein sequence ID" value="ASIC011162-PA"/>
        <property type="gene ID" value="ASIC011162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011162"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011162-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="9925" checksum="6E3BBAD692017987" modified="2014-10-29" version="1">MVPKIFIHRSSLRVLGISHLQVATLVDADRSQDVPMGFSSTTFSSRCETVGSVTRRCAPAPEENNLLHVTLQLLSRSLSTGLQQSDRSAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZK0</accession>
    <name>A0A084VZK0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011190</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525251">
        <property type="protein sequence ID" value="KFB43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011190-RA">
        <property type="protein sequence ID" value="ASIC011190-PA"/>
        <property type="gene ID" value="ASIC011190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011190"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16302" checksum="869B04226BBD7D54" modified="2014-10-29" version="1">MSIRQDLSQPWSKGLWRGKGLTRVEICGIVAKKWIEMNELHCETVGKCATTKGSSKLNLREATVADSIAIGEVKEVVSSASAVNSACVRYTFAKYGELFVVLSLMRIPDSSVSHRARPFGRKGGNGPGYWNTELYRSCVMSAEVRVGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W002</accession>
    <name>A0A084W002_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011358</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019062">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525259">
        <property type="protein sequence ID" value="KFB43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W002"/>
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        <property type="gene ID" value="ASIC011358"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011358"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022070"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011358-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="21407" checksum="2D7F3936692EA965" modified="2014-10-29" version="1">MPLLLRPKIFPGGLVIGLGMHELEPVVVLPADTFEPLAGVAMAHGDPLPMLAFGVGMAPGPSSWCVRSPARTPDNPTLLAKELPAEDVVVVAEAEVLMLAEQVALGLEVDVDVLPTPTRRLLLPALASVPASGTDDASELCTITPLVTVVGEATWGLCSITDDGEPGARAGRRARGTGSEGTFRAWQAEPADVERGVVTTSALTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1D4</accession>
    <name>A0A084W1D4_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011857</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525267">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1D4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011857-RA">
        <property type="protein sequence ID" value="ASIC011857-PA"/>
        <property type="gene ID" value="ASIC011857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011857"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5981" checksum="18E58C4F8C0C76A3" modified="2014-10-29" version="1">MKFADAYGRVHLALHAEQLYSPLFRPSGPMKAHPRLVESFSVALRCELQKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W202</accession>
    <name>A0A084W202_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012141</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W202"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012141-RA">
        <property type="protein sequence ID" value="ASIC012141-PA"/>
        <property type="gene ID" value="ASIC012141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012141"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012141-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9658" checksum="44729D082B7F9F40" modified="2014-10-29" version="1">MTPSVTARGCDHHLNGGLGVLFKVRGEFAGGRREAGRLDRKAIHVHAVTLPIARWPPVGLVKMRPLTTAPHGMGVRWSGDLSTERLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W232</accession>
    <name>A0A084W232_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012055</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W232"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012055-RA">
        <property type="protein sequence ID" value="ASIC012055-PA"/>
        <property type="gene ID" value="ASIC012055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012055"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001655"/>
    <dbReference type="OrthoDB" id="6605882at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784243" evidence="2">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16867" checksum="9A5A60D20FD3087D" modified="2014-10-29" version="1">MKLISFSFLTSFLVVALPCSATDDVEKSLELLDKVLSEFEEEPDRLNLHNHHHNHHHHAAVEPDSPSQGHQSEDDGYMSMNGRRAKFVPDFQPTDEATGAPVSQQQPQQQQQMLQLQHQPQLPVPTEDESYSPPSPEEAERIISNLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2G2</accession>
    <name>A0A084W2G2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00012352</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019615">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2G2"/>
    <dbReference type="STRING" id="74873.A0A084W2G2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012352-RA">
        <property type="protein sequence ID" value="ASIC012352-PA"/>
        <property type="gene ID" value="ASIC012352"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012352"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004186"/>
    <dbReference type="OMA" id="IYAYQES"/>
    <dbReference type="OrthoDB" id="2434995at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="559"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB44406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012352-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="664" mass="72191" checksum="98606221A7524EBA" modified="2014-10-29" version="1">MVDEAMDTSDSLVEEGDAVPKPPDVKPLPLQFMKKFGKPLAKMSRDDLEEFVMQKICEAMVYKSQLGEERKRLDKLEKVMLKYRQRLKDMHKQYSDLQVVHERAVQDLQKRANKFVIPVKITRAVGLQVGFPQFPLMGHPTAMEQTEEDVKTKSGTAVIPAKSNTLSPESSTKGTAGGAVWNGGQLTTIGQRVPTSVAGGIHPLPNVIRPSVPVNVTYMHNATPSAVTIKPADPSKPTVGSLVNGLPGSSFPSSTATSSSSSSTGSVSPGMTARKKTLHKITPKRPPLSAVQQEEQEQMARQQAEKLLQDIHSKQARLAKIAAPIAPDVRTTAMSRLNVNLFRPAMLSSVMAGTQPIAPMQNVRALSSKAPPTFTNSVAPTAPQPQPGRASAASNSLIDLTDEEEPRGPIGGSAPLNNAIEKNHPSQNGTVDKQQGSLAMIATNQMFKLSQAQMKTKLQYRMLNGNGTIQPIAAGSTHTQGMPLSNNVGFRAHLGKKPNGLRMPLAITPTTQGQTRTSGPFADNSLMMKPRPPLRALVHPAPLPKPGPQPCHPSWKQLPPQPVVRINNVPTGIVISWSMPDLSEMHAEIDLYQIYAYQESSAIPTSAAWRHVGDVKALPLPMAVTLTHFSEGQRYHFAVRAIDEHKRFGFFSDARTWIEINVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L2</accession>
    <name>A0A084W3L2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP011220-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00012715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3L2"/>
    <dbReference type="STRING" id="74873.A0A084W3L2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012715-RA">
        <property type="protein sequence ID" value="ASIC012715-PA"/>
        <property type="gene ID" value="ASIC012715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012715"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018037"/>
    <dbReference type="OMA" id="HENLQLI"/>
    <dbReference type="OrthoDB" id="6360905at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin C-terminal" evidence="11">
        <location>
            <begin position="207"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="338" mass="37586" checksum="7E691C3D167B23A8" modified="2014-10-29" version="1">MVRTKISRNTASKRNRTSYQEERYANVMREFEIISESFIVSIDAKLNIDLEKIDRNGELIMSRIPKEFHKMTMGDLRKSGCNVFVNLRDKDLVEDGGRDVSSLSVGSSEARKNSIKSSKTDDGYQTEDYSKLSIDVLASAKPSGRPMGPLASAMKASSRRRSNSVSSNAMTPSKAAQSSLLFGLKTKKTELRTPGVSRSIFANQSDRMSRPKLRTPMVQMGKVARPHTVSTDRGMSQITLKVEPNTPLAFIRHPRAGESVYSLTGSPVVNSVMHKNMANVNIPVPNGVLSLQPTDMDDVDPEALPPIDHATLEHLKKLQSNLNKIMKYAEDCNFRMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3W6</accession>
    <name>A0A084W3W6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="20 21">Laminin alpha-1, 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ZHAS_00012823</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020183">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525295">
        <property type="protein sequence ID" value="KFB44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W3W6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012823-RA">
        <property type="protein sequence ID" value="ASIC012823-PA"/>
        <property type="gene ID" value="ASIC012823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012823"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005672"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011908"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018604"/>
    <dbReference type="OMA" id="TVRQHVH"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000242">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000512">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000574">
        <property type="entry name" value="laminin subunit alpha-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000154">
        <property type="entry name" value="laminin subunit alpha-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000167">
        <property type="entry name" value="Laminin subunit alpha-3"/>
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        </source>
    </evidence>
    <sequence length="3257" mass="360295" checksum="4E5F4DA56C8B4CA8" modified="2014-10-29" version="1">MLFFLLSFSIHNSFSSCDFIFAELKLLSGLTVSTATADYEQQLPKASGLWPSFFNVALRATISVNATCGQTGREEYCRATQESTGRSRGSQCGICDANNPDPEKRHPITNIVDGTNSWWQSPTLQKGAKNDRVTINLDLGQLFQIVFFTMRAAISPLPAAWVLEKSMDGRSYEPWQYFASDDAECRERFGLPAYSANYIFKSDSEVICSTQFSSFEPVENGEINLSLISGRPSEKTTSPELQNFTLARFVRIRLLRIQSAPHQEGSLFDVAKRSFYTIRSLRIGGRCFCSGHAGKCKTIDNNIDNQPQCDCVHNTCGAHCDRCCPLYNQRPYRIGTPVGANKCEKCECHGHAKSCYYDKTVDEQHLSMSIRGKMSGGGVCQNCTDFTTGINCERCLPGYFRPLDRLPSHEQPCLPCDCSTLGTTGDCVPLGGECRCREGFTGPRCTECLPGHAGERCSKCECDSRGTLLGRQCDEVCSCKAHVVGSHCDQCAAGYFALGAVESDGCLKCYCSGVGQSCSEAKVASASYETMLGWTVTNLAMSEQIVPTKDNETGHLVFGMFEMPDTEAVYWKAPEGYLGNLLKSYGTRLSFKMIWITVRGDTSGKPTVGPSLVLVGRNGMKIAYGEESYDESGGATVEVPLKEDNWYHVPRTVKDIITRLRRTEYHGDPVTRTQFMAVLTDVEAVLLRGTYHTDQVESVLEVAQLFTGSAASNSSTQSLIEQCECPAGYRGLSCEECDFGYVRIFETSVTHERIGRCIPCSMCHGHAASCDLETGACGTCLHNTVGTNCERCLPGFYGNATIGLQSDCKRCACPLEVPGNNFSPNCQSKSGTDVDDYVCTQCPVGYTGDHCELCDDGFYGEPTVIGGQCLPCPCHGGPCNAKTGECIECLGNTEGWRCERCKTGYWGIPDDGCEPCSCSEVGALENVCDVTTGQCICKPRYGGRRCDECDVGYGNLDLDCPACACHVNGSASELCNTLTGQCECNVGTEGIHCSHCRDGYFGLSEEQPDACQECLDLTQFPSGPFSNPFFNDVVLFTPLFAGCNCHPNGSIGHDCDARTGQCRCKPNIEGRQCNLCRKGFWNLNAGEGCVPCSCDPNGSERGECDLNTGQCFCKPGVDGISCDRCQVGFYGFSAQGCKRCDVCTSPSYVCDPDTGRCICPANSNGHECRSCIANTWGNEFQKGCKHCACDIVGSIGQACDKQNGQCSCKEGYTGRQCNECAAGYYGYPICHRCACDERGTVQAVDGTFPCDRNGQCQCKSMVYGQKCDQCRQGTFGLAAIHPEGCARCFCFGRAAHQCTQSDHSWGQVRLQGARNLSVEYLERQEGQSEVDYVAILQLEGSRTHREDVNITSMNNLDLIPSSTGNVSIGSYVMFRYPLYFQLPPQFLGDRTSSYGGLLNFTLITGGASVNIPEPSLRQFPLVQLHTHENLVLDHYENPIRYGQTVESHSVRLFGSLWRNHYDGSWINRTILMTALQNVRHIFIRGTITMDFQEVVLTNVTLDTGIFVAGAENNHAYGVEQCSCPPKYSGLSCQNPGKGYYRHRLPIVDLEWATIEDMIGKVLPCGCNGRSDECDPETGVCLNCRNNTGGEHCERCAEGFYGDPNIGQCSACPCPETRKNFARGCTVRGSDVHCICKVGYTGALCDNCMRGYYGHPHLDNGHCEACECNREGSISDECDRYTGECHCRPGVTGRKCDRCELPKHIVQDYRCKICDNCTVTLMDDFEVLSSRLDEETSHIDRNGIPAPWVELTKYETKTRQLANRVARLLEAEDMAKKFTVDFAEPLKRNATRLNKRLGKLDKRITTREEEIGKCMERATDLFDEINVIDGDLRSTIQVLKNYGVGDHHIKLPLAVKEANDLLTDIRDRYGKMEFDETVMDCANKQYDHWANVSKTVAGQNRRLDDLKFEIEQINYKADNLQNYTVQVFRHVQETEVYQTTNQKHFNRARDAYAQALEDETDIRKLLDTNIMSATDVALVQLDDNYGQLTQDNATLHALIEQLNESTEDLIREKSILLETQIPKAVHHAKQLKAKADHIRNKFQTTEDASAKAMEASQAYENIIGAIVVAQQSADNATNMVEKADQLIHPQHDVTISDQSQKALEVSTNLTHRANRELTKATALNETMIQKEKTVQNLKDQIWETAIKNNNLMDELGKVERGEAMKTVQSDLDRAGIVSEQMKFVRQDAINLNSDVYKLKLKLKSLEPEWDTKFGMAEENVSQTFGNIRKAKDKLNGMEALANTQGERFKAWNQTFSAHLQELRDLIAMAKHKAEGIRVSMESAEECIRSYAPASFGPSTTNRLVMSIALTNPNVQNSPLAYIEGDDRRFIALELRQRKIRMLWSLNGSIAEITHPQEIQHRDLKNDDAWYFIDATRTFNLGTLNVRQMSPNGVLINARPVTGASSPAFTTLNVSPSNRIWVGGIPDDLRVPELEPSQGLGVAVSQLYVDQRQIGLWHFTSSSGKCTGAMLGPQEIASSTNERNFNGNGYAVLKRASDAKTKAQFSLSLSFKTLDEDALIFLALDEKNNRSVSLTLYQGLLVFRVDYGDDTRLELNTTERYNTGRWVEVEASRMYRRSTTDVGVLKVNHDEPIHGSPTKPIGAAMLPVLSDNYYLGGVPPGFQTGTTKAPGADHAFLGCVKGLLIGGSSYDPLDSTTHFGIETSCDSTIVQAGFFGHGYVELPSFSLKKRANFGFVFRTMQPDCLLLLSAYPTRVQDDYDSKDTLGNYSVFLSEGRVNLWMDAGTGRIELVSNDTLNDGEYHVLTVIKQGRHVELRVDDKFQMSKTLQSSVVNMPGASGGLFIGGVPDDPSFDSLSKVFEGLKGVVANVVFNNQTLSFGQAMNFTNVQMGRTGPAMGSQGLYTALMKTEPIGRSFKAAPEGCHRVGSYSYEPNAFKYGDKPQSYSVVTVQARHIWQRNFHIEFDFRTFYPNGILFVALGTKEKAKHFIMLSLKDGVLKLTVRGRKRDQLLLPPKLNDGQWHHVTLSSIKKKATLSVQIGSSLSSAQLKLPKKLNAANALHIGGLPDEVPILPKELQPRPEEFKGCLRKFSVNNNTQDLARPGRHLNVGQCFPRIERGSYFPGDAYAIYKRNFNVGKFVEIELEVRTSEMNGILMSVADQINGFPAFSLEISNGNIILSVDNGDGNPTRVSTALPSKYTLCDNRWHNISALYEDHQIVLRVNEYPPTTLLPHGTTGFGRVNTKAPLYIGGLPDAASSGTLLMRENFKGCIRNIVVRNERKDWTDMDDLHNVLLSECLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W400</accession>
    <name>A0A084W400_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00012855</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525296">
        <property type="protein sequence ID" value="KFB44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W400"/>
    <dbReference type="STRING" id="74873.A0A084W400"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012855-RA">
        <property type="protein sequence ID" value="ASIC012855-PA"/>
        <property type="gene ID" value="ASIC012855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012855"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003387"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxin 13 N-terminal" evidence="12">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012855-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="19898" checksum="02B9385DD3B834F1" modified="2014-10-29" version="1">MVSNFRNPTLNEERIFGNPNIISTPSGMIPTSHPPPLPPRPQFLGGGGDTMYGNRYGFAGTSGYQGYSPYGGYSSMDYYGHRGYGGYMGQGYGGYGNPGGFPYPEQRFIQLAEESSRPAFQILESLVGAVGNVATMLDSTFFAVTSSFRAVLSVAANLAHLKGTFAQFWSSLAIVRAAVWLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Q6</accession>
    <name>A0A084W4Q6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013164</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4Q6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013164-RA">
        <property type="protein sequence ID" value="ASIC013164-PA"/>
        <property type="gene ID" value="ASIC013164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013164"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="16401" checksum="7DD90F43555248D7" modified="2014-10-29" version="1">MEVRCGTILRKRDRHPTDDMGDAMKDGSLLSCLPWHHHHHQTIIIQQQAERRISASSPSTSRHLANGIFLRPIKKSHPGTQRGDVRVSRGQKGFYPRTGGELCLREGTVEMFAWLSAAFKRAVLIRAEPQKVVRQKRGCVRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4R9</accession>
    <name>A0A084W4R9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013179</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4R9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013179-RA">
        <property type="protein sequence ID" value="ASIC013179-PA"/>
        <property type="gene ID" value="ASIC013179"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013179"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013179-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9128" checksum="5743BBA5CF100C13" modified="2014-10-29" version="1">MFGCDVSKELDGIRLVHKNAMIPNDHPSRSDGPLDWTDCCNWHCRLADDRSIAETRRSGPLLLSTGTWHPIEPTRREEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W500</accession>
    <name>A0A084W500_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00013238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W500"/>
    <dbReference type="STRING" id="74873.A0A084W500"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013238-RA">
        <property type="protein sequence ID" value="ASIC013238-PA"/>
        <property type="gene ID" value="ASIC013238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013238"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016412"/>
    <dbReference type="OMA" id="ACNYKLR"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013238-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29986" checksum="BCFE46F194A2ED3D" modified="2014-10-29" version="1">MDPHQLQSTEREKSEKVKISNQVKHIPKDAQVVMSILKELGVNDYEPRVINQLLEFTYRYVTCILDDAKIYANHARKKVIELDDVKLATQMILDKAFTTPPPRDVLLEIARNRNVTPLPLIKTHCGLRLPPDRYCLSACNYKLRAAQQPKRMNKSALEGRSTLKTGKASSGGGSDSSGTGGSVKRPSVQSTPKTQVVSIPKPTFKFSTAAKTTPAATKTVKTSVTSNALGGTNGTAGGNGGPAGGVEVKMEQDDQFGDTSSNKRKREEDDFEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W583</accession>
    <name>A0A084W583_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Hedgehog protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ZHAS_00013215</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell.</text>
    </comment>
    <comment type="function">
        <molecule>Protein hedgehog N-product</molecule>
        <text evidence="24">The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.</text>
    </comment>
    <comment type="function">
        <molecule>Protein hedgehog</molecule>
        <text evidence="24">The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>glycyl-L-cysteinyl-[protein] + cholesterol + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:59504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:15369"/>
            <dbReference type="Rhea" id="RHEA-COMP:15374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:143135"/>
            <dbReference type="ChEBI" id="CHEBI:143140"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:59505"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Sonic hedgehog protein</molecule>
        <subcellularLocation>
            <location evidence="24">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Protein hedgehog N-product</molecule>
        <subcellularLocation>
            <location evidence="24">Cell membrane</location>
            <topology evidence="24">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the hedgehog family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W583"/>
    <dbReference type="STRING" id="74873.A0A084W583"/>
    <dbReference type="MEROPS" id="C46.001"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013215-RA">
        <property type="protein sequence ID" value="ASIC013215-PA"/>
        <property type="gene ID" value="ASIC013215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013215"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001438"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002067"/>
    <dbReference type="OMA" id="HWVSSLL"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016015">
        <property type="term" value="F:morphogen activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.16.10:FF:000001">
        <property type="entry name" value="Indian hedgehog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.10:FF:000001">
        <property type="entry name" value="Indian hedgehog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
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    <keyword evidence="14 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 24" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 24" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="24" id="KW-0256">Endoplasmic reticulum</keyword>
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            <begin position="232"/>
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    <sequence length="440" mass="49013" checksum="D591351FC5B7F8D6" modified="2014-10-29" version="1">MDLSASVASEVQCGTVEGPVGGEMATRLRADRAHRRQRTVLLLVALLALVQLLPGVESCGPGRGIGGPRRTRKLLPLVFKQHVPNVSENSLSASGMQEGAISRNDSKFRNLETNYNKDIIFKDEEGTGADRVMTQRCKEKLNILAVSVMNQWPGLRLMVTEGWDEDHMHAPESLHYEGRAVDIMTSDKDRSKIGMLARLAVEAGFDWVFYESRNHIHCSVKSDSSQANHASGCFTGDSTVLTESGAHRKLSELRIGERVQAVDATGQTVFSEVLMFMDRDTHQRREFVTIEAEGGALLHVTPAHLVMVWRRERSETRFVFADRVREGDHVLVQAADGALEPRRVHRIAATLAEGVYAPLTREGTIVVDRVAASCYALIDSQSVAHWSFLPYRVAQKLGALFERSSATDSLSLPRHEGIHWYAKSLYAIKDYLIPANWLYH</sequence>
</entry>
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    <accession>A0A084W5V8</accession>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5001784423" evidence="2">
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            <begin position="23"/>
            <end position="198"/>
        </location>
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        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013681-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="198" mass="22157" checksum="4AF6A3AC3750BC63" modified="2014-10-29" version="1">MNCRLFFVLLSVAVIAVKGTAGAGEDIWAKYALKPTLSTTPVKAPALQLQKKEQPQVKAAVPEGRSVPTTKSARNEPEVEVEEDVDETASEKKPIPTIILDGPPPKREIPIFAKMILGDPQRPKLATVEEMRKYDLRSVSMGLELPNKNTIPLTKELLEKSAQVLRLFQEIQEESNNFVLDIEKHNENSDKDYIGYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Q4</accession>
    <name>A0A084W6Q4_ANOSI</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013861</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784621" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013861-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13204" checksum="A7F54270C66DAABC" modified="2014-10-29" version="1">MEKRGFPEGLSLFCLVCNFALQLVACNVCVSVCECVLSATAACSIVPGLSSFLRFSVFRAGSNGSIDTPPSIGGGNGCGLSVSVAAVAMVVGAFDDTTRRTRHGQFSLRDRFACRVAFEGDRKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7R0</accession>
    <name>A0A084W7R0_ANOSI</name>
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        <submittedName>
            <fullName evidence="2">AGAP004589-PA-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00014285</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Anopheles</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084W7R0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014285-RA">
        <property type="protein sequence ID" value="ASIC014285-PA"/>
        <property type="gene ID" value="ASIC014285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014285"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016271"/>
    <dbReference type="OMA" id="QCIALIN"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetyl-CoA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:N-acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAA80"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014285-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19833" checksum="3D62D3197C4D8F63" modified="2014-10-29" version="1">MTPPTDSPDTKEAFNVVPIHKHKELMDQCIALINSEWPRSYTARLWSLESSKETLPTSFVLTANAKAGVVVLAHAKLSPIPADREAVFVESVVVARERRGQGIGKLLMREVENHCFQNLRLKKIYLSTIDQEAFYTKLGYKLCSAISIFGSRPAANKSTKKSGCSKMRHVEMKVVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8L1</accession>
    <name>A0A084W8L1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP009897-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021492">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021493">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8L1"/>
    <dbReference type="STRING" id="74873.A0A084W8L1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014591-RA">
        <property type="protein sequence ID" value="ASIC014591-PA"/>
        <property type="gene ID" value="ASIC014591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014591"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020710"/>
    <dbReference type="OMA" id="MVKYKVD"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF460">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="84"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014591-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="494" mass="54805" checksum="A2ED39296BA14538" modified="2014-10-29" version="1">MDNYKKKTPGRVQHLEYTQIRPQLTGSSKSELPALIFGRMKSDQNEVPAQTAAGSTLPLVDMIKDDEEAGSYNPFEHRKLTHPTTDMETLVHLLKGSLGSGILAMPLAFVNAGLWFGLVATIAIGAICTYCIHILVRCSQILCRRAQLPSLGFADVAEVAFLAGPEQLKKYSRLARFIINLFLVIDLVGCCCIYIVFVATNLKQVVDHYTQSYWDVRIYILMLLGPLILINLIRKLKYLTPFSMIANLLIGAGVGITLYYILSDLPPIAERKAMAEVQHLPMFFGTVIFALEGIGVVMSLENNMKNPQNFIGCPGVLNTGMSVVVMLYASVGFLGYLKYGDETKGSITLNLPVEDVLAQMVKLMIALAIFLTYTLQFYVPMEIIWKNIKGNFNEHQNAAEYTLRIGLVILTVIIAAALPNLGPFITLIGAVCLSTLGLMFPAVIELVTFYEKPGYGRFNWVLWKNLFLIMFGVVGFVTGTYVSIVEFSEHLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9F3</accession>
    <name>A0A084W9F3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002287-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525322">
        <property type="protein sequence ID" value="KFB46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9F3"/>
    <dbReference type="STRING" id="74873.A0A084W9F3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014851-RA">
        <property type="protein sequence ID" value="ASIC014851-PA"/>
        <property type="gene ID" value="ASIC014851"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014851"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003307"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014851-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5383" checksum="5C1BB549F369F15E" modified="2014-10-29" version="1">MECGSNLTSPKHQLKTHFDDIIMSETTSTCSGTMQVESSDTSLEMAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAD1</accession>
    <name>A0A084WAD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015197</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525328">
        <property type="protein sequence ID" value="KFB47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WAD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015197-RA">
        <property type="protein sequence ID" value="ASIC015197-PA"/>
        <property type="gene ID" value="ASIC015197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015197"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002724"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="507" mass="54024" checksum="BFCDD46F330FE2B4" modified="2014-10-29" version="1">MFSFFKRSKSQKGKQKHDQKLQLPPEEQQLQTACGEPKPQGTARKESTGSVCLGANDGVKPSVDVSKVAAEANAGANGWRRPPAVGDEEKLARAKNNNNPPGPQPAAGADRLPSRCLATVARGEVTDVALEREPPSAASVSPSGPTCRSGRVPNNDNDSPNETRAVRDEFFPPIDSDEDGAGDRESSSPIDDSRHWERGTQANATSSNPYAPPSESAMAKGRNRRRYQPQQQQVKTQQHQHQQQQQQQEQQNALRRGDSSGAPEGKKGVPPTHLSLGKPMTTIVLVEQTTIEPLTNGDVIIERSPKEQAMTEKAEPMPSTDSCDRAAKTHTANGGEGVGELVTLCADSPPKVTATTGDGVGGGTNTRSAPALNEGDALLNIKNISPTTTAKEQEQERGEDHDGVDGMRDGDLRARELGLALHVGSCEPAAKPTISKQTTDAVVANGSVEEAXXXXXXXXSKSSGTRRNRATPTGMTSDGFRGPLVSKMIHLTARLRTSVRYVSGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAQ6</accession>
    <name>A0A084WAQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015331</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525330">
        <property type="protein sequence ID" value="KFB47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015331-RA">
        <property type="protein sequence ID" value="ASIC015331-PA"/>
        <property type="gene ID" value="ASIC015331"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015331"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015331-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8745" checksum="C4A51734C7A5FD8F" modified="2014-10-29" version="1">MINFVANDILLLRSGLQQEGMPLQPDKHIQVLVLEKDKEPIAYQIGLRPLAKTPAEWRLTSFESWPDDWVFIVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAZ5</accession>
    <name>A0A084WAZ5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00015635</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAZ5"/>
    <dbReference type="STRING" id="74873.A0A084WAZ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015635-RA">
        <property type="protein sequence ID" value="ASIC015635-PA"/>
        <property type="gene ID" value="ASIC015635"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015635"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019662"/>
    <dbReference type="OMA" id="CQDEMEG"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="252"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015635-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="454" mass="50861" checksum="C3FC01CEB38E27D3" modified="2014-10-29" version="1">MREIVHLQAGQCGNQIGAKFWEIISEEHGIDATGVYNGESDLQLERVSVYYNEASAVSRSSGGKYVPRAILLDLEPGTMEAVRSGPYGKLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKVPNPSYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLAVQNKNSSYFVEWIPNNVKTAVCDIPPKGLKMSSTFIGNTTAIQELFKRISEQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADDEFEQEECQDEMEGECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBD0</accession>
    <name>A0A084WBD0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-protein ligase E3C</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type ubiquitin transferase E3C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RTA-associated ubiquitin ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00015484</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with 26S proteasomes. Interacts (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UBE3C family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01022343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBD0"/>
    <dbReference type="STRING" id="74873.A0A084WBD0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015484-RA">
        <property type="protein sequence ID" value="ASIC015484-PA"/>
        <property type="gene ID" value="ASIC015484"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015484"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011141"/>
    <dbReference type="OMA" id="EKHYYFI"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000014">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="769"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015484-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1106" mass="126800" checksum="4C74EED24CC02892" modified="2014-10-29" version="1">MFNFDGEFRRRPQQNLGGASQKTDRLSVIRKAQQERQKREEARRQQNGAIVIQSAVRSFIQRQQTKRRERGKFDEYRKTNGIRNGHDLEYLTKRILFFYQQQTGQDGDRLIFLCQYMIKNPGETFKHVASEVIWTYRIKRLLGLCLGQILIPEHSPTIPMRMLEIYSSNTYISKHLPPGATPNQQHQAIQQYLTTVYGHLIEHRYFHVVRQLIEEKVPSIDTDTTTMPHPIADALFDMLLRPLKLVQPDPQDALSRQILQSFTFNILSSTLSDQVKHFVLPTLGERDDFPYWTLVRCIADEYQAQLDRRSANLIDLTDDSTRKSATPKKARRNQSKDERLRLTSSLLYAFLKLDKRHTADKTNSKAQFGAYLKVIASMMDNINKLPRKTIRSSVNRPLDDSSDSESDSEDVPALSPTEGCLLQEIIGMLNEGRRVAYIVRTIDTVLDEPVTLQHLCQICHQLMTYNRMAVYEYKLLYMLASKPMIIRSLWYTLMAHSDGQMFTTPIVLLSKGINICKEDSDRTIPVLASFCALFGRLIASLHDGEFVQENVLPGTVSSIMPFSISELIPLSTTLKEISLGLVELAFPETRSFLQENYRTMISSLSTDRSSTGRSRYEPNRQVWPHLLKVCVSLLRQIHTRDLRRCFCPEGHWTAQNLNLPLDKPTDLHLSRGSRRNPRPFQPIRDFTREDVEDGPPLSTKQIRSITILREIPFVVPFNTRVGVFQGLVAADKLRTQGDLQGFLQGPTTQLTVRRTHLYEDAFDKLSPTNEPDIRPKFRIEMVNSAGLREAGIDGGGVFREFLSELIKLAFDPHRGFFMITKDNMLYPNPSVGKIVEDFQRHYYFIGRILGKALYENLLVELPLAEFFLSKLAGKHSDVDVHQLASLDPILYRNLMSLKAYEGDVADLGLDFTIVCDALGETRVEELKPNGANIIVNSSNRIEYIQLMADFKLNQQIRAQCAAFRQGLANVLPIEWLYMFSNKELQVLISGAEIPVDVHDLRKHTRYGGDFSLEHHTIQLFWKVVEQFDDIQRRLLLKFVTSCSRPPLLGFKDLDPPFFIQNAGDTDRLPSASTCMNLLKLPAFEEEDILREKLLYAIQSGAGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBY0</accession>
    <name>A0A084WBY0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00015790</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01022517">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBY0"/>
    <dbReference type="STRING" id="74873.A0A084WBY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015790-RA">
        <property type="protein sequence ID" value="ASIC015790-PA"/>
        <property type="gene ID" value="ASIC015790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015790"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019636"/>
    <dbReference type="OMA" id="PAGICNN"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002972">
        <property type="entry name" value="GM18664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000450">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000096">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015790-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44656" checksum="C8ABA777EA518038" modified="2014-10-29" version="1">MDYNISRLCRICLEEGVFTSIFSTELVAMAPANMLVMCANIKVSKNDGLPSTICNNCMYRLGVAFHLKQQCENSDMRLRQYIGLMTGVYSNVLDKETMTEESWLLAGSEEKGDGQKSSKKKYGSRKRYKPKLPEERKKRGPKPMPKIPQTCYQCHKTFKCAAQLQMHLRTHSGEKPFACNYCTRRFAQKHNLSIHIRTHTGERPYQCEICSKQFSALGNFQAHKKIHTNERDHVCPSCNKGFITSGDLTRHMISHSGIKNYHCDICAKSFSRNRDMVAHKRKIHLNDRSNESYKCPECHKVFATVDTLNGHMRIHGPVVPSSSIAVVPPGVLLPPHQPQIQTPIALAAHGLGSSSLGVGLGMLPHPSSHPTHPPPPPPPQPAYHHSQMHPAQRLHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC75</accession>
    <name>A0A084WC75_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylcholine-sterol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015775</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC75"/>
    <dbReference type="STRING" id="74873.A0A084WC75"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015775-RA">
        <property type="protein sequence ID" value="ASIC015775-PA"/>
        <property type="gene ID" value="ASIC015775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015775"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015094"/>
    <dbReference type="OMA" id="LHCLYGD"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48490" checksum="B71AF0AFA7EABFE6" modified="2014-10-29" version="1">MRVHLLLVFSLVLICYCSPSSGVFFNHGGTYLGSLKRLFKRYEHLLDPGRKLSPVIFVPGDGGSQMDAMLNKPSKVSILCQKQTTTFFNIWLNKELLLPLVIDCWIDNIRLEYDNVTRTSRNSPGVVTRVPGFGQSETVEWIDPSHASVGAYFVNIANALVSNGYARDKSIVGAPYDFRKGPNEHKEFFLSLKFLVEQTYTLNGEVPVSFVVHSMGAPMTLHFLQMQTPDWKAKYIRRVISIAGAWAGSVKALKVYAIGDDLGAFALSGKVMRAEQITNPSLAFLLPSPLFWKPNEVLVRTQSRIYTMDQMEDFFNDLDYRNGWEMRQDTLPYTLNFTAPGVELHCFYGSKINTVESLEYQKSYDLSGTPVLKMGNGDGTVNIRSLEACKQWATQQKQPIYTKEFPGADHMSILSDVNVIDSIMKVLLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC79</accession>
    <name>A0A084WC79_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP009883-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00015780</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC79"/>
    <dbReference type="STRING" id="74873.A0A084WC79"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015780-RA">
        <property type="protein sequence ID" value="ASIC015780-PA"/>
        <property type="gene ID" value="ASIC015780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015780"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019838"/>
    <dbReference type="OMA" id="APMCFVG"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB47823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015780-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="337" mass="35432" checksum="A07881D05371B8C9" modified="2014-10-29" version="1">MLSRLACGRQLVSPTLLKSALQTVPKRQPVFRQYARDVKGGSNTTQWTARAERMSLRERAMAPPGPNAYAIGKGALAGGAALGLGALCFYGLGLGSGTSTLENSHLWPEFVKERIRDTYLYFGGSVAISAASAVAVFRSPRLLSLVSRNGWMSILGTFAVMIGSGMVAQSIPYSPGLGTKQLAWGIHSAILGAVIAPMCFVGGAILTRAAWYTAGVVGGLSTVAVCAPSDKFLYMGGPLAIGLGVVFASSLASMWLPPTTALGAGIASLSLYGGLLLFSGFLLYDTQKIVKRAEMHPLYAARPFDPVNSAMSIYMDTLNIFIRIVTILAGGGGNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC82</accession>
    <name>A0A084WC82_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP010353-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">DRMBL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00015898</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022586">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525334">
        <property type="protein sequence ID" value="KFB47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC82"/>
    <dbReference type="STRING" id="74873.A0A084WC82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015898-RA">
        <property type="protein sequence ID" value="ASIC015898-PA"/>
        <property type="gene ID" value="ASIC015898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015898"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000001">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="363"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015898-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="561" mass="63927" checksum="6BEA4AA0B37AFD70" modified="2014-10-29" version="1">MSKHGRKEQSTEDSTSSPLATDRMNTESAIENSGSPRSISSTRVEVRSPEPIVISSDNENDFASSAEKKVPKTVPRKTIVKVRRKICPSTNIKHLTKKYFDDSQKRITNFFSKEENTQQIGYCRVLKESAMPTIITGDLDVEQMLNIEVEEAEDHLSFSQTAAESSTQAQEEMCPMKIMERIERVESACYDQVREDWNMERVQVPMEIDKTYNDETTDLHQSIFINGIEIIALDANHCPGGIMFLFRLVDGTNILHTGDFRASPEMEEYPEFWNMSIDCIYLDTTYLSSKYAFKSQWESVADARETVSAYLKKHIGTKVLVVCGSYLIGKEKVWTEIAISSNMKVWTEPNRWKALKAIADTNQLSVLVADPKEADIHVLAMNKLTYDDLNEHLNQFPDRYDSVIGIRPSGWEKNSKPQYRGRINIVGVEYSEHSSFDELKRFVQFLRPREVISTVPYGNSNQNRTPSVPTAWYQGEIRPNRKELQLSITTFISTPVGANSGRLLKLSSTSARLAKVKTKQEKKYSTEAKVEEVIDLVSDNDEDNTKRSENGEYSFDSDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCN9</accession>
    <name>A0A084WCN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013141-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016093</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCN9"/>
    <dbReference type="STRING" id="74873.A0A084WCN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016093-RA">
        <property type="protein sequence ID" value="ASIC016093-PA"/>
        <property type="gene ID" value="ASIC016093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016093"/>
    <dbReference type="OMA" id="RMSESYP"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042407">
        <property type="entry name" value="NCBP2-AS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41161:SF1">
        <property type="entry name" value="PROTEIN NCBP2AS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="79" mass="9311" checksum="DF1A799D84F1B0BE" modified="2014-10-29" version="1">MILRYLANNEQLIQRLADSYPLRRAAQMVLSAYYRSRSIAEQQKLIGMSPERLQQVIRNFKTNVQKEIENAKNDLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCR3</accession>
    <name>A0A084WCR3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022847">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCR3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016123-RA">
        <property type="protein sequence ID" value="ASIC016123-PA"/>
        <property type="gene ID" value="ASIC016123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016123"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784879" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016123-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5430" checksum="5A8346307F6AD8F2" modified="2014-10-29" version="1">MPRPVWGRVAFSCCCACRLTVALGHSEQTARRLQDFCRNSPSGLQDSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD94</accession>
    <name>A0A084WD94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016257</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016257-RA">
        <property type="protein sequence ID" value="ASIC016257-PA"/>
        <property type="gene ID" value="ASIC016257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016257"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8764" checksum="39E49F9BC0CBB585" modified="2014-10-29" version="1">MMLLKHRKEHRFLNFHTIDPNYSLPVDAYAVVAGPGVVACSPKEKEETTDKGGRSKDVIELDEDDDVEPYVVPCGPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WD96</accession>
    <name>A0A084WD96_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00016259</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01022956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525338">
        <property type="protein sequence ID" value="KFB48190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WD96"/>
    <dbReference type="STRING" id="74873.A0A084WD96"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016259-RA">
        <property type="protein sequence ID" value="ASIC016259-PA"/>
        <property type="gene ID" value="ASIC016259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016259"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016742"/>
    <dbReference type="OMA" id="NKICARD"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000502">
        <property type="entry name" value="Tyrosine-protein kinase Drl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000165">
        <property type="entry name" value="Tyrosine-protein kinase RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="17">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="250"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB48190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016259-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="516" mass="58326" checksum="672AA806F4932B9B" modified="2014-10-29" version="1">MPFHCCRLSAEIYYVREGQVNEYALHFTVPVPADVEEISFTWQNLAKKPLPYRINIVSPDPIALPKPSMNISWQGEIPEHIETFAIGLRCSGRESAEVDVTITVEVTLDRLTGNATELVFRRKKICLMSEHPDANQPDPYLLENASNGQNGLITLVIGGILAILFVALITLIAFCTRGSFHRKPHNAQPIRTSSFQRLQTHAPSAPSSIHSPPSIAPTIATLSRTRIYANAEPEELQRRISELTVQRCRVRLSSLLQEGTFGRVYRGSYNDSQEVLVKTVGPHASQIQVSLLLHEGMSLYGAQHPGILSVLGVSIDDHTAPFLLYLAPENSRNLKIFLQEPVARTLTTIQIVKIQLQIAQALGHLHSHGVIHKDIAARNCVIDDQLRVKLADNSLSRDLFPGDYYCLGDSENRPIKWLALESIQFKQFNEASDTWAFGVLMWELCTLARQPYAEVDPFEMEHYLRDGYRLSQPINCPDELFAIMAYCWTMLPMERPSFEQLQIYLQDFYAQLTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDH1</accession>
    <name>A0A084WDH1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016390</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023009">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016390-RA">
        <property type="protein sequence ID" value="ASIC016390-PA"/>
        <property type="gene ID" value="ASIC016390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="119" mass="13462" checksum="FEEE703F3C3B1882" modified="2014-10-29" version="1">MVRLVRCHKLMKAEAEFGEEKFHPDERPNTIKQIVINCRWADAVVKVVAAYFWPKNRTSHPPGWTQTTPSRWTASRHSAAKQTVSGVFCSSGNFSQPNFHVQCSLKAGCRSESVIFRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDR9</accession>
    <name>A0A084WDR9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005019-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDR9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016483-RA">
        <property type="protein sequence ID" value="ASIC016483-PA"/>
        <property type="gene ID" value="ASIC016483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016483"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013601"/>
    <dbReference type="OMA" id="KMWRPTG"/>
    <dbReference type="OrthoDB" id="7925836at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016483-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="184" mass="21497" checksum="52C8F4E571B16DA6" modified="2014-10-29" version="1">MAEPNKTSSRQKFVDAYIALVNKISVERFNEFKPFFANEKDLESAVQTFRDGLQEALVAQVNKLWNETDIDTNVEMLEMLKSKAAGNTKKMWRPTGKTVSEQVRPLVVNKLNMSLKFYHHQLAFQKERTEELLYKLETMRAKYRAMQERRANLLQQIANEQDTFTSVRAHQRQLDNLVNGDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEZ9</accession>
    <name>A0A084WEZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016804</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEZ9"/>
    <dbReference type="STRING" id="74873.A0A084WEZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016804-RA">
        <property type="protein sequence ID" value="ASIC016804-PA"/>
        <property type="gene ID" value="ASIC016804"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016804"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016804-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15687" checksum="8811B6E3208E39AA" modified="2014-10-29" version="1">MPTVMDAIIHAMIDFRKEILDNLQLSLEYHTEQLEEIKFYVEKRINDVGKTLGEISSELDLRSCDRVKSNYTSTFYISPHGNIEKPFMVLCYFDNNFNLGGGWTVFQRRIDGSVDFYRNWTMYKHGFGDVSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFA6</accession>
    <name>A0A084WFA6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017164</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023322">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFA6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017164-RA">
        <property type="protein sequence ID" value="ASIC017164-PA"/>
        <property type="gene ID" value="ASIC017164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017164"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022663"/>
    <dbReference type="OMA" id="VGMCFSV"/>
    <dbReference type="OrthoDB" id="7762401at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017164-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="223" mass="24794" checksum="C1532FD610D2FD85" modified="2014-10-29" version="1">MMTSSPAPTCLAHFILAGVTGWSLKHLPEQRSDGLPFVFSLLVFLLAYALLGLVRFSHPQPSLAMRKLYERFALLARVCPLPFLNAQLFVEHHQPERFCPESLVPFCHKSNLGYAFLLSALVAFVAGCIYSELSQRHLADRVATVVLLLNLSALGVVSCDTGNYWGVGLAVSFGTKHFALPWLADRFCIPFVDLYTYGLIFYEIFTVNVVFEAQFAAGETVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFW9</accession>
    <name>A0A084WFW9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">ZHAS_00017265</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="23 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFW9"/>
    <dbReference type="STRING" id="74873.A0A084WFW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017265-RA">
        <property type="protein sequence ID" value="ASIC017265-PA"/>
        <property type="gene ID" value="ASIC017265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017265"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017172"/>
    <dbReference type="OMA" id="HGPRKNS"/>
    <dbReference type="OrthoDB" id="10064659at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15030">
        <property type="entry name" value="7tmF_SMO_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000068">
        <property type="entry name" value="Smoothened, frizzled class receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035683">
        <property type="entry name" value="SMO_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784891" description="Protein smoothened" evidence="20">
        <location>
            <begin position="21"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="73"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="242"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="693"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="840"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1124"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KFB49113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017265-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1147" mass="127340" checksum="CD7FA4A487FF1A08" modified="2014-10-29" version="1">MAVLKTIFFLVVLSATIIEGKEFIPTTNLITPEAPRPMLEPINGTRNYRMHGKKGKDDKTWFDGREMRYIYCVRPGKCEPIKHKSCLGSTLPYSSFSLDLTDSYSQEETHHKLYQYNALRHVPKCWAVIQPFLCAVFMPKCEKINGQEMVYLPSLEMCKITLEPCRILYNTSYFPEFLKCNETLYPSKCNNDVREEMKFNATGQCLKPLVAADLPANYYKDIDGCGLQCKDPLYTDHEHRQIHKLIAWGAGICLTFNFFTLATFAIDWHNANKYPALVIFYINFCFAISCLGWLAQFTPGGREDIVCRKDGTLRTSEPSAGENLSCIVVFILVYYFLIAAMVWFVIFTYVWHMSFKAIGKIQDRIDKKGSYFHLIAWSLPLVLTITIMALSEIDGNGTVGICFVGYLNPPIRGGFLLAPVICVLLIGGYFLGRGLLTLIRLRISSKEIISARASRKIHQTIVRMGICTAFTFVFIVATVFCHVHEFRHSAAWATALRNYIVCQISSTYTDDVMTGSCRIEQRPSVAILQLHLICLFASGIVMSSWVWTNSTLESWARYFRRRFGTDVDEPVKLQKHKVIAQAFAKRKEFQNQGRLSISFHNSHTDPVGLKFDINSAIGSHDFSSTWANNLPRFVNRRCALTGAATSSSHDPRKNSVDSEISFSVRHVSVESRRNSIDSQVSVKIAEVKTKVASRSSRGPVVVGGGKHHHHAHKTRQSRRRHDFASAGRRYSRKESSTSVESQIITAALQKTGSVSAGAGRHSASTAAGSFGGNMQRRTGIGALDADQINDLISNGKLLLPFLQGQGLTTSEDDNVSVGSFKLQDSKFDIILKQIDGIGSSGAGVRSDDAIGTSAVTGTTSGCRIEEYRSSDDDDDDDDDDDDDRRTENEPLRGRNGTLRPITSGRDDTVQARVADAASGGDGMRSSKEGGRVSKGSITKGGRNRKTGGSSRPGTLRKSQHHNHHRTHSAHRKDREKKEKAREREKELELIERAGGGGTNNHKQSASKACATNQASADIEMYDFNHDSSFTSYCSELLTPLNINSSYSGVSLAKTNSRNSKRSCDVGIQTNAHEIATQTMSSFEFNEKALKNEENEDIYTENHQLLPKLAPAMIVVGGGGGVGRKQRDANDSGMSDAEKLKMLLLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG52</accession>
    <name>A0A084WG52_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00017197</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG52"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017197-RA">
        <property type="protein sequence ID" value="ASIC017197-PA"/>
        <property type="gene ID" value="ASIC017197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017197"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023052"/>
    <dbReference type="OMA" id="ISCTIEV"/>
    <dbReference type="OrthoDB" id="6695098at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="368" mass="41805" checksum="2C8526C9B996B60F" modified="2014-10-29" version="1">MGLYREQRVLLAVLGWCSMLATPISGGTPTTKLAHRLYCLRVGVILSVLLTFLYLRVWDITRDFHLVSVSYVMWLTSVIAETCVIISTLLANAYNVSSFRALSDLIEHLERTIEERNTAGHVYPPYGVAINALMVVYLVYHSMQMYISYQMGLSVLLQFRWELLIADFYTIQLSFLLLAIGRGARQLKRMLQEAILSNRGADVCAVLRLRDDLVRAVALVNRCYGVFFLGCGVAWVVSITSILYFDFVLEGAFFLDARRLVLHAVTFVWKSALIGGLLMVAGTVMDRVNEIMQATYRCETHPSNNRRLTKMLDKALLKCQFQDINFTVYGLLTIDNSLSYTVIGSIVTYLVILVQFRQVEERIENMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGQ8</accession>
    <name>A0A084WGQ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017503</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023682">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGQ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017503-RA">
        <property type="protein sequence ID" value="ASIC017503-PA"/>
        <property type="gene ID" value="ASIC017503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017503"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017503-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7038" checksum="91A8F0DA40E36B7C" modified="2014-10-29" version="1">MPIDVGKGAAVRLRCRLLRGFLEGNNLPIGSVHERRNDDAVFPSVFEMAKGWHAVLHRELADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHW2</accession>
    <name>A0A084WHW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AGAP012292-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00017824</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHW2"/>
    <dbReference type="STRING" id="74873.A0A084WHW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017824-RA">
        <property type="protein sequence ID" value="ASIC017824-PA"/>
        <property type="gene ID" value="ASIC017824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017824"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012588"/>
    <dbReference type="OMA" id="VMFARYL"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB49806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="541" mass="62460" checksum="D5151CBA0E35EA69" modified="2014-10-29" version="1">MAVDMVTVAALVAIVALVYYYVQKKYQYFLDKPYPHLKPTFLVGSGGPMLFRRRDMMEHINVLYNSFPDAKIMGAYDCLTPNLMIRDPETLKQIAVKDFDYFTDHTPFVPNEKDVMQSDNMFLNSLFMLRGQKWRDMRATLSPAFTGSKMRQMFELVSESGQGMVQHLLAEARRDGATQQYEMKDIFSRFANDVIASVAFGIQVNSFTEPKNDFYTKGKKLLDFNSFMSSVKFLLFITVPRLMLKLNIELMDAVLCKHFHEMILDNMRVRDEKGIVRNDMINILMQVKKGALRHQKEEVDTKDAGFATVEESTVGKSAITRQWSDKELVAQCFLFFLAGFDTVSTALGFLCYELTMHPDVQEQLYREICEVDQSLEGKPLTYDAVQAMRYMDMVVSETLRIWPPAPAVDRYCNRDYTFDDGEGLRFKIEKGRTIFIPISGLHSDPKYFPNPKKFDPERFSEENRHNINPGAYLPFGIGPRNCIGSRFALMEVKSIVYYMLKSFTFERCEKTQVPLKLKKNPAAISTEKGIWIRLKPREVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHY0</accession>
    <name>A0A084WHY0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00017844</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01023896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WHY0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017844-RA">
        <property type="protein sequence ID" value="ASIC017844-PA"/>
        <property type="gene ID" value="ASIC017844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017844"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012680"/>
    <dbReference type="OMA" id="NDAYENE"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB49824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1529" mass="168933" checksum="41A5D88F74A77972" modified="2014-10-29" version="1">MVGSELNEKASSDDVPGPAEERRIEDVETSVGDCLDIETQRMDETTQDSEKLPLVASEGKLGGSLEGTAQTQDAEQQQIVPDEVHDDQLEESRSDASVRHDFPDVEDDLRHCEGEKIVQTNEICDRTSAEEDASSRSSPTQPPPSDERQQPEAEPTIGPSLVVRPTARLLEFVAETPAESSLVDCDTICDTSNTVNEQTGTVSDTLCMDASTIPEAEAIETREIFEPEPSSSIEVLHSGEKEMEQTSTRASRVLPVSSMNKSTRKKGKKRPAKSSPASSTTRPAAKRKKQVNLQHIKPSSPPVFDSSEAPVSNEVVSDCSTDGFSAVERPSISTQERDEVEVVEVSKVAQSDTAQLELTSKNNTSNQTISEGKDESLSKMETEERKSNAKKKVGRPAKKRQVSDVGGEGDSQLHPSRHDLQAVEVAVHNGRATRAAKRRKLKRKKRSTPRDEGGSDTDTPIVTASSTIDDITRAADTRTRRAATTFKRSKASKLSKAPNTDEQFVISEVAAGDDSHSADQSRVLEVINVRYQRTASQLASSNSTQQTPAGSAGIVEDGNPRLDPTTGETAPSGPGPVDAADSGVMVYKCGNCGKELHRSAWQEHFAFHNGVAFREGIDAPIDLQDVKAVGYAIHRFMKTNRRSEVICEKCSEVKKSHLGMASHLRTCGIPKEAIEATKATCEHCGRKMKVVSFATHQLLHCRVLREQRLKEAAEQVQAQPVQVYSGPSGDEASSQLSASGRKKRRSHIFSSRVKQLLIKVTNRMISRGILIGWLKEMKETGQTTCRHKGCFFVGTSEEMMRNHSKLCPYAGSTAPFYECAICQHQEANQMRMYDHVRQVHQVELNAAQNAPSDNESDANDAYENEMRDDGATSSSDMDVTVKEEELEDTDDDGKGRKRKQPAKRGAPKNAKATKSRASKNRASDGDDVLNETGVLVDEGEVYKEMVQAEAAELRLQRNNIQFTTIQWMFKFHREHYATRQLFVQLQPDVDVRFLTMLAIRDYLPHSIHSLRYQRRYAKHYDEPYELGPSDSWRQLFTFQGEVLDGEPIFYCGGPVTTLDWLPIPSDEGDDATMDQILAIACKSGFDDYYTCEQLSSPVPRKCLIQIWNVGPLRNARESKSATPRCPQLSFAIACDFGPIWQLSFCPSGCYNELDRGDCFDRLGLLAASGSDGDVYVYALNRSMVSARIELPDTKPTPRIVHLQPVLRLSLTLHNRSLFGDTNAAHQSFSGHAVMRIAWSRGKGHTVFAAGYSNGAAAVWKLTEASFNSPLLGALKDGIQTLLPTQKILNVSTGSVSAIDLHYGQGSRYLAVSNADRRLKVYDLHSGHHQPVEVLSLQARSRITALHWMLHYPVLVFVYDDVFLSDRCGYTVHQPREIGLRTMPLITLGTEATDLAVNEWISTNAISTDGGDVVSHRPIPFVTGIPGKNFGQLLTMTNSVGISNVNTSELDLSSYEAFANNFALVFSDTDKNPSQSDRKSLQIKTFRRGNIAQYPGIRVNQIRWNPNSSSFLYHAIGYQAGFVRIRKIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIF6</accession>
    <name>A0A084WIF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP011949-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018041</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023930">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIF6"/>
    <dbReference type="STRING" id="74873.A0A084WIF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018041-RA">
        <property type="protein sequence ID" value="ASIC018041-PA"/>
        <property type="gene ID" value="ASIC018041"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018041"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014730"/>
    <dbReference type="OMA" id="MHIDELW"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="157"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018041-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="29965" checksum="F31054283D76F151" modified="2014-10-29" version="1">MDPPGENVLCYKTSHKSRGKALVINYTKNRSGSEKDTKDVAEVLKRLQFDVRVENDLNEMELLLLLRQVAAEDHTESDCFVMVVMAHGKTEKITVDGIDFAVDRLWQNFVGNHCPSLIGKPKLFFIQSCRGSKYETEQGDNEPDADPVPCNEENFILPIHADLLVMYASYYDHVAYRNKMKGSWFIQALCDVLRGEIRQTELLSLLTDVSYKVVYNYSLHSGEKGKRLLQIPMITSMLTKKFYFVEKDIPAVKGSEDKRENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIQ4</accession>
    <name>A0A084WIQ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018151</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIQ4"/>
    <dbReference type="STRING" id="74873.A0A084WIQ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018151-RA">
        <property type="protein sequence ID" value="ASIC018151-PA"/>
        <property type="gene ID" value="ASIC018151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018151"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008947"/>
    <dbReference type="OMA" id="QYCYELE"/>
    <dbReference type="OrthoDB" id="4788989at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018151-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="455" mass="49911" checksum="C05A78B60762A1AE" modified="2014-10-29" version="1">MDIERLKCKQCGKFPDGEIFECAAKEHIMCVGCAERSKKILCPCGAKLIVKKQRNPIELLVQNVKTICRYEENGCTWKFTASEMDAHVQECKFRPYRCVASTLNVLKCDWIGLQHEIEQHLVESHKELGPVFRFCESSSMVFKENVSLGGLKVVDAFSKHFLFHFFSDAAKKTLSFLMVYFGRHEESDQYFFELHLRSLPGPETVQKSSDAQGADAVAEPLNTGVVESVKFVERCYSDSENLTELLEEERCITLTHRQVQKYLHNGKIYFSYKIRKADALGKERKVSEQEGMASTTTVGKPKPRPPPFKFVDKGKVSTNSKRSASSSSTSSSTGSSSTSGKSTNSSETSSSGKSTPIGGPVASRSPSSASTLTITSERNSAIGTPGAFLRSNSSTHSLSSINRIIGPDSPFEKPGHCPLLTPSINKLDMVSGPGRQGKQRKAPRGGRGGGGRAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ24</accession>
    <name>A0A084WJ24_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018287</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="EMBL" id="ATLV01023963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023964">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ24"/>
    <dbReference type="STRING" id="74873.A0A084WJ24"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018287-RA">
        <property type="protein sequence ID" value="ASIC018287-PA"/>
        <property type="gene ID" value="ASIC018287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018287"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010299"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760018" description="Trehalase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018287-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="624" mass="71445" checksum="B8050FC81847A9FB" modified="2014-10-29" version="1">MLQTRRQADKRRRLVSQWMSILVCLLGVTAVVHGAALVAKDVSYIVDNRQQETLEPSCPSEIFCHGELLRTVQMSEIYPDSKTFVDMKMRKSPNETLDSFHEFMTAENNSPSKAKLQEWVESNFEKPGAEFENWVPEDWKANPAFLSRIRDTDLREFASKLNQIWHELGRKMTPDVALNPDLYSIIHVDNPVIVPGGRFREFYYWDSYWIVKGLLLSEMYSTTKGMLSNFLSIIERFGFIPNGGRIYYSMRSQPPLLCGMMKAYVDATKDTQFAMDNVDTLDREFQFFMNNYLTEVKGHQLATYGYKSSGPRPESYREDIISASIFENEQDKQDFYCELKAAAESGMDFSSRWFIKDGTNAGNLTDLKCRSIVAVELNAILYWNALIIAEFYGLRNDIASSNKKTEYLNRAEELKKAITSVLWDEDEGVWFDYDLLNNKPRKYFTPTNLSPLWVGCYDKSDTTLPKRILAYIDRLQLDRFPGGVPNTLQNTNEQWDFPNVWAPMQHMLVMGLDSLDNQEAKDMAFSWAQRWVRGNYIAFNKTHAMFEKYDAQELGGHGSGGEYDVQTGFGWTNGAAMDLMNKYADRLTTVDRIEDNGGNGALVAYSVNTGIIATVIAFFVGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJR2</accession>
    <name>A0A084WJR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018488</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024046">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525348">
        <property type="protein sequence ID" value="KFB50456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018488-RA">
        <property type="protein sequence ID" value="ASIC018488-PA"/>
        <property type="gene ID" value="ASIC018488"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018488"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018488-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6706" checksum="214DD66AAAEC4D42" modified="2014-10-29" version="1">MVRKAGNKKRPRSPSREEAVRRSVFVEVQKNSVRSIHFSSLEFGRCRNCLDEVGEWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WK67</accession>
    <name>A0A084WK67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005645-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00018931</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WK67"/>
    <dbReference type="STRING" id="74873.A0A084WK67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018931-RA">
        <property type="protein sequence ID" value="ASIC018931-PA"/>
        <property type="gene ID" value="ASIC018931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018931"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009862"/>
    <dbReference type="OMA" id="EWTRMID"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018931-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="245" mass="26102" checksum="3E5684324DA11A25" modified="2014-10-29" version="1">MDRWVGKVAVVTGSSSGIGAAIAKDLAKAGMITVGLARRVERIEALKKELSADAAARLHAIKCDVSSEADIDATFKQIEEKFGGVDVLVNNAGIVRSNNLLDQGNLVDLRAVLDTNVTGLVLCSQWAYKSMVARSVDGHIVHINSIAGHGVPNFPKLSIYPASKHAVTAITETMRQELRAAGTKIKVTSISPGAVKTEILEPLEGTAEMPMLQSEDISQAVLYAIGTPPRVQVHEIIIKPVGEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKD4</accession>
    <name>A0A084WKD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006279-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00018716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKD4"/>
    <dbReference type="STRING" id="74873.A0A084WKD4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018716-RA">
        <property type="protein sequence ID" value="ASIC018716-PA"/>
        <property type="gene ID" value="ASIC018716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018716"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009483"/>
    <dbReference type="OMA" id="QQFYKRA"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB50678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018716-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="189" mass="21122" checksum="7B5D0211AF1ACD9D" modified="2014-10-29" version="1">MTTRIFNIVVVGDGAVGKTCLLHAYTDKSFKNFYEPTIYDKESIEMILDGQKYTIQLHDTAGQEEYDKIRQQFYKRADCFLLCYSVDNKVSLENAVTKWIPEIKTDPPIPIVLVGTKLDTRRGKSDEVTTADGEKLKRSINANSFVECSAKANINVELAVEEGVRACLMGVPEPEPDDPWACCSSCLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLV8</accession>
    <name>A0A084WLV8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysosome-associated membrane glycoprotein 2-like luminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLV8"/>
    <dbReference type="STRING" id="74873.A0A084WLV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019466-RA">
        <property type="protein sequence ID" value="ASIC019466-PA"/>
        <property type="gene ID" value="ASIC019466"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019466"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018022"/>
    <dbReference type="OMA" id="YSSSNWL"/>
    <dbReference type="OrthoDB" id="6248302at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF40">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785206" description="Lysosome-associated membrane glycoprotein 2-like luminal domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019466-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="276" mass="30959" checksum="C6C4ED828A7C8EAD" modified="2014-10-29" version="1">MFSRRELLYLKAIFFATLLHLANALQLEGLSTKKPRITKYTMKPTASSATAVPSSLSLYRLNASSGATCILIQTDGLLSIQYRDKYNEDKEADTFMPDQMDISGECWEDESRITLAWKGFTINMYFSKTPGGERWYVNSVDLAYSSSNKLFEHIDRPGLDVKLSTPPGTLLFPTPVGKSYTCDKELTITMFAQDENDKSGHLAKLYLRELRMQSFMYKAGNAWGPTFQCSATGTYRDETAPIAVGSTLAVATVCTVVGYGLWRYFKVKKFQYGTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMX6</accession>
    <name>A0A084WMX6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019639</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMX6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019639-RA">
        <property type="protein sequence ID" value="ASIC019639-PA"/>
        <property type="gene ID" value="ASIC019639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019639"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022876"/>
    <dbReference type="OMA" id="KHEGANG"/>
    <dbReference type="OrthoDB" id="10540620at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="240" mass="24143" checksum="1C40F97A6090474F" modified="2014-10-29" version="1">MPRCYIVKKQQPPAVVTSAYRNRTGTTVVTTANPGNHHHQQQQHQTTTSRQVLVVNGKSTPGKDVEQVAERNGGVVRRAGDVRVVTRAEGGSGSSSNSSSSGSSALGNVIVKSNGVTVGKEATGSGSGRAGGNGSNLVILNSVSVISGGPGVGSGVAMDGGKGKVSESGGVVGFTLSNANGGAAGGNGAGIVQRKDDANGPVSPTEGCVAPIYYTNISDNKSDKPFRITLISVILEESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNT5</accession>
    <name>A0A084WNT5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020036</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024696">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525357">
        <property type="protein sequence ID" value="KFB51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNT5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020036-RA">
        <property type="protein sequence ID" value="ASIC020036-PA"/>
        <property type="gene ID" value="ASIC020036"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020036"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023459"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760036" evidence="2">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020036-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="271" mass="29007" checksum="21543E00E2DF058F" modified="2014-10-29" version="1">MAAEGSVLRIRALCAPAILLTALFVLTLLSCATDATVPSPTKANKFASPDTNYRSYHFVLLVKSEGSNRTGASSDVSEELVIMPADANLLERSTGGAIELKPQPLPGHITSTLLKKYQTNRSLQKRHQLAPAADIPTKTEPAVSPTASELQHPTIQLHTVSRGHGKKQRYPKKVGAVKTSPTTTEGTTMSVQKSSLRLLPVDDREDGLAPYEVVATSKGSLPAQPRTVRKTAQQTAGDGSQPKPRYEVIGTFRDAHGARTKPQRLSAVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNV8</accession>
    <name>A0A084WNV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020063</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525359">
        <property type="protein sequence ID" value="KFB51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020063-RA">
        <property type="protein sequence ID" value="ASIC020063-PA"/>
        <property type="gene ID" value="ASIC020063"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020063"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020063-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="57" mass="6394" checksum="CECA3E866DE45123" modified="2014-10-29" version="1">MFEANFLRRPDRADDGQRHRSARLAVFSSIFRCSNADGKLENCDRAGRRGAPGSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNW5</accession>
    <name>A0A084WNW5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Maturase K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020071</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024754">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525359">
        <property type="protein sequence ID" value="KFB51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNW5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020071-RA">
        <property type="protein sequence ID" value="ASIC020071-PA"/>
        <property type="gene ID" value="ASIC020071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020071"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="161" mass="18315" checksum="8A1F7C935A74D5ED" modified="2014-10-29" version="1">MLVHSTQQSCLCPDGYHYHLWIRRAPNTPSSVSFTLGLWHRVEDLRITFMSDASVSSQLAARLPPELASSLLVRALARDRSVPAAGRLEAVWKVHIKRLIYCLSFRILFVIVLYFAPFFLLLEVRIVREFRSGRLSPEEDAPEHIPPTQSGADLYVPQVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNX2</accession>
    <name>A0A084WNX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">30 kDa salivary antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020102</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020102-RA">
        <property type="protein sequence ID" value="ASIC020102-PA"/>
        <property type="gene ID" value="ASIC020102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020102"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006245"/>
    <dbReference type="OMA" id="PWLADMP"/>
    <dbReference type="OrthoDB" id="7744842at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="16276" checksum="927A8F076B43A20D" modified="2014-10-29" version="1">MTDVTAKTETTPVPNEKEVESDEATPQVASTDASEETAATDKTAAETEKVDATDAATTEEAEKNGEEEKKDNGVATEEDAAAETEPKESTNEVEEEEGKEQEGADKVAEATKRKATEAKADGAAVEVDGAEHTTPEKKAKLDESSDAKAAEEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPC3</accession>
    <name>A0A084WPC3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">G-type lectin S-receptor-like serine/threonine-protein kinase B120-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020272</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025031">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525368">
        <property type="protein sequence ID" value="KFB52067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPC3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020272-RA">
        <property type="protein sequence ID" value="ASIC020272-PA"/>
        <property type="gene ID" value="ASIC020272"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020272"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020272-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12416" checksum="0F34400DAB7B1260" modified="2014-10-29" version="1">MVTANVDGNGHFCGTFSSLELTNQQNLACWFPPFERSQQLDWNCRNYATITDRRRQRVCGTDTPKNSRAEELTDNRSAATKPAHGASEPACCCVKHQQITKLPQSTVTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQN9</accession>
    <name>A0A084WQN9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00020782</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025642">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525396">
        <property type="protein sequence ID" value="KFB52533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQN9"/>
    <dbReference type="STRING" id="74873.A0A084WQN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020782-RA">
        <property type="protein sequence ID" value="ASIC020782-PA"/>
        <property type="gene ID" value="ASIC020782"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020782"/>
    <dbReference type="OMA" id="WHGGIAR"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF12">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020782-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="19639" checksum="4DDC71DA62589554" modified="2014-10-29" version="1">MMFGIGTKKARLHVNMFTNLLGEDRNGWGLSHKGLLWHGGVARNYTKRFKENQPTKIGLLFDGIAGTLTYYKDDVCLGIAFRGLNEVREPLYPIVCSTAAKTEMLLSETRRDFVNLQDRCRAIIIKHVNTREKLDRLALPYFIKNYLSEAVTESNTQVTPLELHLIDQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRQ8</accession>
    <name>A0A084WRQ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">General transcription factor IIF subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Transcription initiation factor IIF subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00021181</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRQ8"/>
    <dbReference type="STRING" id="74873.A0A084WRQ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021181-RA">
        <property type="protein sequence ID" value="ASIC021181-PA"/>
        <property type="gene ID" value="ASIC021181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021181"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022273"/>
    <dbReference type="OMA" id="PIADNCY"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015849">
        <property type="entry name" value="TFIIF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB52902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021181-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="31515" checksum="58D2CD0A1FE8C5CC" modified="2014-10-29" version="1">MSKDGEAIRVDKELDLSNAGRGVWLVKVPKYMANKWEKAPGNIEVGKLKISKQVGQKAQVSLTLSDAVINIDPSEEIPRDHRLDVSVVTKQTLGVFSHATSTTNRDDSVPECEKQYMEGRIVQKLECRPYADNCYMKMKLESIRKASQPARQVKSLEKIVHNYKPVSDHKHNIEDRERKKAEGKKSRDDKNAVLDMLFNAFEKHQYYNIKDLVKITRQPISYLKEILKEVCDYNMKNPHKNMWELKKEYRHYKEDDKKDDDAPKDMSGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRY2</accession>
    <name>A0A084WRY2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021266</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021266-RA">
        <property type="protein sequence ID" value="ASIC021266-PA"/>
        <property type="gene ID" value="ASIC021266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021266"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785113" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021266-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7205" checksum="075AFEFD65BDC8DE" modified="2014-10-29" version="1">MGKIAPISRGLIVVVRGCLLLLLTKGPKPAEHNPQRLTSVAVWSLNRSSRRVAGGNGALVQVTECGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRZ0</accession>
    <name>A0A084WRZ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP006657-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DNTTIP1_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00021275</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01026283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB52984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRZ0"/>
    <dbReference type="STRING" id="74873.A0A084WRZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021275-RA">
        <property type="protein sequence ID" value="ASIC021275-PA"/>
        <property type="gene ID" value="ASIC021275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021275"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000689"/>
    <dbReference type="OMA" id="MVIQRVW"/>
    <dbReference type="OrthoDB" id="5860246at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="286"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB52984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021275-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="470" mass="50490" checksum="A941A8FC1D71C8F7" modified="2014-10-29" version="1">MVIQRVWRSSTASSSNAAPPASTASTVGVPSVATVSAATTTLATSASDLHSTNNSSTNASEADSNNSALLVRQKLKNTLSGEATLEALKQRYSSGRSFMSQTANDAAIKSLELLRANIQCYFDKEVDTIVKKFHQTYFVPAIRNIKENLGDGAISEEALKSVFCSLLENTKAQYGSQLSSPAGNSLSRANTPGMELSDSDSSTDNTPSAGVATSLLHQALKRKLPEPNQPDLFKRQYFLHGPIYPHVQYQGLPAQPTGSVSASGSATAASRTPLLSIPTTTITPDSLFILDFKVARALGTPDFRERLANKHPEVLRYCPDAQDRDWLLQQKQVTPLNKNGRFFLLALDDIKKLIERNAFENSSSFGKSIDLQGFKVTELIYAKIQKLLKELTDRQRSTTDAFESPKAPIGTAASTGLPSRQRISSLSSSHATLSALLATPHSQPAESVTSSSSLGTATTTESSAAESRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSE8</accession>
    <name>A0A084WSE8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003022-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021437</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSE8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021437-RA">
        <property type="protein sequence ID" value="ASIC021437-PA"/>
        <property type="gene ID" value="ASIC021437"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021437"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022404"/>
    <dbReference type="OMA" id="REYMDIT"/>
    <dbReference type="OrthoDB" id="10264298at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="1">
        <location>
            <begin position="55"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021437-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="171" mass="20301" checksum="C09274AF40B73682" modified="2014-10-29" version="1">MPRRKPITKLGVFGKYDLNPEQAVENYFESKFNNKFYTNVPGWDVARNGFELKGIHTDREYMDITREQNRMRERSQRQAAANWKRLQQTTNLLNQMRTEFVELNDFLKDCEMKENNALDTVKREKEKHEQYGVKIAQLEGDIETLDNFVVQYEATIAAFEPFEVKSRSEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSH4</accession>
    <name>A0A084WSH4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Ras-related protein Rab-30</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">ZHAS_00021468</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26 28" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01026544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525415">
        <property type="protein sequence ID" value="KFB53168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSH4"/>
    <dbReference type="STRING" id="74873.A0A084WSH4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021468-RA">
        <property type="protein sequence ID" value="ASIC021468-PA"/>
        <property type="gene ID" value="ASIC021468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021468"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000297"/>
    <dbReference type="OMA" id="IDDQKIM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000440">
        <property type="entry name" value="Ras-related protein Rab-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00093384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KFB53168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021468-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="29055" checksum="1EDE832178DF7959" modified="2014-10-29" version="1">MEDYKFLFKVVLVGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVDNQKIKLQIWDTAGQERFRSITQSYYRSASALILVYDISCQPTFDCLPDWLREIQEHANSKVLKILVGNKTDRDDREIPQDVGAEFAKQHGMYFLETSAKQADNVERLFYDIAAVLIEVSRKQDSRRYEERVQNDLYSLQQARTKEFTLRSETSVLTNLSQKTIYHPSCCSVGDRNHASNVSDAHYSDSSGPASLASNSGNFITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSX2</accession>
    <name>A0A084WSX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021624</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026739">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525418">
        <property type="protein sequence ID" value="KFB53316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSX2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021624-RA">
        <property type="protein sequence ID" value="ASIC021624-PA"/>
        <property type="gene ID" value="ASIC021624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021624"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021624-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="5443" checksum="F70F218E005BD300" modified="2014-10-29" version="1">MMLNAVGAGGGAGMIGKLPGQPGAGMQSSSLPPYYYGSSGAGGGAGSNNAGGGIKNDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WT21</accession>
    <name>A0A084WT21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021676</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525419">
        <property type="protein sequence ID" value="KFB53365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WT21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021676-RA">
        <property type="protein sequence ID" value="ASIC021676-PA"/>
        <property type="gene ID" value="ASIC021676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021676"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6499" checksum="2FEFC43E22099CD7" modified="2014-10-29" version="1">MGGGRESVGAARCAPARGKPEPEEPPSRAPGREEEGTHRRRPDPQTKRNPIQTGENIPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU23</accession>
    <name>A0A084WU23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Kinesin family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022094-RA">
        <property type="protein sequence ID" value="ASIC022094-PA"/>
        <property type="gene ID" value="ASIC022094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022094"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022094-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8022" checksum="9BA42274E5BB7411" modified="2014-10-29" version="1">MPYPAAAVALSPNPSVVMANGSPAPTVGVLDDMAAAAATAAAAAAMTEALVVVVPPVEAEEAHEEEDEEGYDWGAARDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBJ0</accession>
    <name>A0A084VBJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001711</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01007457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01007458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524413">
        <property type="protein sequence ID" value="KFB35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC001711-RA">
        <property type="protein sequence ID" value="ASIC001711-PA"/>
        <property type="gene ID" value="ASIC001711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001711"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15082" checksum="365008DAB1FC2255" modified="2014-10-29" version="1">MLMQMYCSGGSGGGEARCQQVLSLLFQPPRPPQSPSTAAREALDNEGTTKTRVISIENDRLSSDCDQIGVQVGSVGLDRWHWELKLSSRGQTALLAVEMRGCFAFCISATVLVTSRXXXXXXXGNTEVHFIWWKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBR2</accession>
    <name>A0A084VBR2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524503">
        <property type="protein sequence ID" value="KFB35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBR2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002045-RA">
        <property type="protein sequence ID" value="ASIC002045-PA"/>
        <property type="gene ID" value="ASIC002045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002045"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="82" mass="8885" checksum="8E0EA6AD3F67364D" modified="2014-10-29" version="1">MHGLLTTSGFERGSTVFWYAPTGHCRCPPVSPPPHRRPPRAAPTTESARLAPEDGSVADRAGRVLDQQLNVCSIHITTLNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VC49</accession>
    <name>A0A084VC49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP001347-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00002371</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01010370">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524580">
        <property type="protein sequence ID" value="KFB35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VC49"/>
    <dbReference type="STRING" id="74873.A0A084VC49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002371-RA">
        <property type="protein sequence ID" value="ASIC002371-PA"/>
        <property type="gene ID" value="ASIC002371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002371"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024518"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002371-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="494" mass="54517" checksum="DC66A4B2EFA73CC9" modified="2014-10-29" version="1">MSKPGERALQAIKEQDKTVAVFKTPVVPKAKTKDKIILTEEEYLQEMGKIIQRDFFPDLQKLKAQNEYLDALASNDVFRLRQIFSKYSSKRPNSSRIASPATFETPLPDTTPASELPPSIRSTSTVSSSKSTKSIGDKHSLDSFLQSYTSEDNDSFQEIIETADRKLRQKFAVLYQAEGSAAIEMNKCLALPSIEQQFDQREKPKQLDMWTYTNKNFIMYTPEGVELTKEEQLEMAKRKQEINHSCTRLHQNPFNDQDSKQAIVEAAKTQAKHLPEKIGVDGKVVDTSSDTPKVRGFGFVKSPSPCPGVTDSPLFTWGEIEGTPFRLDGGDTPLHPSSAGPSFRIVETSKRENLALQLAEKAAEKSREKKAKAIEAARRNMASPMVRSSFERLASMSPAARRLATNKIGFLSTPSPLRSPARSVGLKTPTMRGPGSGKARQIVPSPVGMVRRKTPLVSAGDRPNVISKGGGADLTDDLLDIPTGGKRPKAADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD09</accession>
    <name>A0A084VD09_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524641">
        <property type="protein sequence ID" value="KFB35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD09"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002795-RA">
        <property type="protein sequence ID" value="ASIC002795-PA"/>
        <property type="gene ID" value="ASIC002795"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002795"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002795-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6891" checksum="785C8BB7DA79174E" modified="2014-10-29" version="1">MDKRQQPSVNQQPEKQTAENQPSGSKPLDASSNQPQTPTALQSIKSMKPIVTRPLTEVTSKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDI3</accession>
    <name>A0A084VDI3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003011</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524664">
        <property type="protein sequence ID" value="KFB36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDI3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003011-RA">
        <property type="protein sequence ID" value="ASIC003011-PA"/>
        <property type="gene ID" value="ASIC003011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003011"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020129"/>
    <dbReference type="OMA" id="EHPVTHQ"/>
    <dbReference type="OrthoDB" id="7739657at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783573" evidence="1">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003011-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="280" mass="30319" checksum="A3EFBFC4D6C0C20B" modified="2014-10-29" version="1">MVVSGVFLAPGRRSTKDRSVCVLFQRNAVWLLLLVAGATVAEPQEGYFYPRPTPQCLPQVFTETVTDYATETLNHFFTDVNTVYLTDYLTSTVVNPVLITSTEYSVSTVVVPQVEYITETTTLVLQPSPVVQYVTETFVSTVFAQSEFSGAVQPVPLGNTYLPPSGPPEPNPVLINHAINQLQQPPPFIPPPRVSLPPVLDHPVTHEPFLSLDVSSGGQRTLGGPAEEHAFGSGVYSLPNIGAVPPAFDNGGYRYKRKLNVQVSEQSSSTTVATKTDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDM4</accession>
    <name>A0A084VDM4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005437-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00003098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDM4"/>
    <dbReference type="STRING" id="74873.A0A084VDM4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003098-RA">
        <property type="protein sequence ID" value="ASIC003098-PA"/>
        <property type="gene ID" value="ASIC003098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003098"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008585"/>
    <dbReference type="OMA" id="MAYAKND"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14675" checksum="14DA67DD8B9E6212" modified="2014-10-29" version="1">MPPKRKSVTDEEDDEYRRKRDRNNQAVKRSRVKSKQKTEETQQRVNELRVKNQLLEDKIDNQKKELKFLKELFLTQAQAKADKLVGVNLNELLQDDDSDDEEEESKERVKPSSSKGEGSKSRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VE22</accession>
    <name>A0A084VE22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002798-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524768">
        <property type="protein sequence ID" value="KFB36216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VE22"/>
    <dbReference type="STRING" id="74873.A0A084VE22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003327-RA">
        <property type="protein sequence ID" value="ASIC003327-PA"/>
        <property type="gene ID" value="ASIC003327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003327"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000105"/>
    <dbReference type="OMA" id="VWSQTGR"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000217">
        <property type="entry name" value="Gram-negative bacteria-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783282" evidence="2">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="34"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003327-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="389" mass="43393" checksum="0C70C71CC9393F6C" modified="2014-10-29" version="1">MKGVALFGVALLATVAVSLAGKNEKCAVSVTTASGTRARPGPYCTGELIFEDNFNTLDFETWEHENTLSGGGNWEFQWYLNHRSNSYCENGIFYIRPTLLSDDTGEAFLSSGTLNIHGGQPADQCTNPQNWGCERSGSPTNLINPIKSARVRTVNSFNFKYGTMEVRARMPTGDWLWPAVWLLPKRQVYGTWPASGEIDLLESRGNLEYVSNGVNIGAEQFGSTLHFGPSPTLNGWETTVAYKNTPPGQGWNTGFHNYQMTWTPDYIRFSVDNQLVRQIDAGTGFWNRGNFGNISPGTENPWIHGTRMAPFDQEFYIIMNLAVGGTNGYFPDVPPASNGPRGKPWSNNSPTATRDFWNARNSWLPTWRMAENRGKQSSLQIDYVRVWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFJ4</accession>
    <name>A0A084VFJ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003900</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012423">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524792">
        <property type="protein sequence ID" value="KFB36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFJ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003900-RA">
        <property type="protein sequence ID" value="ASIC003900-PA"/>
        <property type="gene ID" value="ASIC003900"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003900"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003900-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15758" checksum="16A530D8ACB1FD6A" modified="2014-10-29" version="1">MKWVQTSNANPSYLSPLQNAIRTAHDTPVPGFYNRTSISENGVGYDRFQAVLLSSHTVGNFIVHWPKKWSSVVVGSGSLHTPRWRNGPGPEAGTPNLTLKHTVETLTGHSRGWHGDGENCISPAEYYPLDDGNGRKRKRHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHZ0</accession>
    <name>A0A084VHZ0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Receptor mediating netrin-dependent axon guidance</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00004824</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VHZ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004824-RA">
        <property type="protein sequence ID" value="ASIC004824-PA"/>
        <property type="gene ID" value="ASIC004824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004824"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002725"/>
    <dbReference type="OMA" id="CCAAQNV"/>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF155">
        <property type="entry name" value="IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN C25G4.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="268"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="495"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="697"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="947"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1385" mass="150893" checksum="005A51F5A342B974" modified="2014-10-29" version="1">MVHVGEDALLTCVVMTPFNNDTVLWRKGPHEILSAGMNRVTGDRRISVLHDDSPKGRTPLGGDVWVLLIKETRVNDSDVYVCEVNSDPIVRSFHPLTVRQAKKKTASSRNATDSAGSSTTAPPEHSEAGVTSEEEEDSDSDTYADSEEDVSPDGVPLVTHDFTDCCHANNVSSGCMGFCVLHNILDGSAGVEPEQCERDFPNIVRCMADGRNHVPCCVEKGIPDLCQDMCRGEYTPFTDLLKSRVSCVQHTLPGLQCILDNIQRLPSEPQSVSVEPLTERSLQVSWMAPEKLGGTVKFYQVNATRLHAFDQDALANATDAKDGLVTLQVSADQTTAVLSNLMPFTMYTVTVSAHNDHGSSLPSMRIRALTLESGVVSKQTSVAVVPVLPDVRGCCVKKGITHRTCLEKMCDPVKADFTEVPDLMVCAPWANITFACLANNIDHTPCCKSRGIPEGCLSFCSGTVKALNFNYFKCLQYMSEYSSCLLQGYGVLSGPPSKLKAPLIASHFVVLEWKPPKILPDTVTAYHLHYRKLGSGEEYTVLEKDQAPVIVEDLEAGTYYEAFVVAVNAHGKGGPSPRLVFQTKRDLRLDPPQAFYNISACCHASGLLPQCSPLCSYDAKMSDIQKLGNTCRGQIGTIVRCSAGGRDHTSCCSRRAVPPKCQSLCRGVITSSPADCLPFAGNIIQCFEEGIGHIPPPVEDLHVTSVTNTSISLAWVPSEMEPNNTELKAADYLVQYGKVNNMTMYETVIKLEHELNTTETDIELKDLEPKALYRITVVSRGEHGTSLPSSMLLINTSRTDSASTVYGAPSPPHSLTVSAHSATWITVAWQPPEFSHPHESITYRVIHKVANNYTVIDTRLLWPPTVHPSDIISEGGSMTILCLAMGNPAPTISLYVGGHLVRQDTSRHMITVIHNVTTDMEHISCYADNGYGIPMQAAKKVNISFAPRIQASGILVASMGDSVDLKCTIRARPIPKTMFWRDHDGRVPVIQGGNYVMSMTNDVDDNALYVMTLTINKLTPQDVGDYFCHAENALGSSTRAVSVRIRNTAASFNTSECCVAQNVSSACMSACSFYIDIESVIDRPECIVDFDKLMRCAADGSDHRGCCASKEVPRRCLNWCRGEPITPPGICALQHTRTIVGCFQENRDRLPGPPQNLKVQVLSDEKVQIRWDPPVKNPNTVEGYRVFWHDLEPVSDNLSNVINGLATSRLDAKETSIILEGLRPNVMYELVIKAGNHLGASVLSEPLHFTLGDHHITSASHATNAGVVSGIIAGLIAIVLAIAALFIVKRRKFGQKQANGGVAFENPSYLREMNVEHVQIPAVSGQTVGNGADWRQESLHAANGTATTGLGHDNAVVPMATEVNPSLYEELKLGHDRAGFKRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI38</accession>
    <name>A0A084VI38_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004870</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524849">
        <property type="protein sequence ID" value="KFB37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004870-RA">
        <property type="protein sequence ID" value="ASIC004870-PA"/>
        <property type="gene ID" value="ASIC004870"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004870"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004870-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12482" checksum="C9C099B2053D233C" modified="2014-10-29" version="1">MAGVETETDPSHWQDEQSLSSRQTIILTAERFYQHRLPANTNVRRMRTVAFRFGGDYKHGYTKARSQLQTNGTVDGLRRSSWFLGWCSVGTLLARALGTDERTFEDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJI9</accession>
    <name>A0A084VJI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004473-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005417</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01013601">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524871">
        <property type="protein sequence ID" value="KFB38133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJI9"/>
    <dbReference type="STRING" id="74873.A0A084VJI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005417-RA">
        <property type="protein sequence ID" value="ASIC005417-PA"/>
        <property type="gene ID" value="ASIC005417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005417"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004487"/>
    <dbReference type="OrthoDB" id="6257037at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005417-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="690" mass="77069" checksum="09CBDA6B4300EE44" modified="2014-10-29" version="1">MNNDESWSSRSLTASVASVTNCSCVCHGSKQSVPQVAVHSLSASQPCRGETIDRCNHGDDNGRITLPPEATRNVSLSARNKDVVKHSVNRLAASATLYVVLKRYLKELKEQCKQELVGGSVFKPSHPIGKVYLHMVQLAVYGRFLDGLRKMSDNLAAYRHRYSSLQQYNPQRLSGLLQLFHFQETDGSFVVSARYISSSYDYCSMEDKDALFAFNYYEKVEETLLAAGRSDLLERFEEVVKRFNELEDSAPQLYYTVEDLLGESFPELVDMFLTFLLPGQAAEVGRFFEHFILTNMNDFLEKLNIFFAKQPSQIKKVHACLNELSNEPNVTIEQVKLKVLPLLKGSTLLTEWFLQLFPTERPPESPLCDYENVTLKKRSTRSPPIPVWYTNRYRTLRRSQKGRIYQGTLPARLTFLANHCLRPKNDPDATANGGNPESYILCDEATLKAHAIRLNPLVHCPKGITYADVAHLLLPEGNKDANGGPSASESGNAADESKGTSSPKKVPPKLPIKKRFNSPTSRKISNSPNEDTNVGKEPQAAAPSKKTPNVSATVIPGDSKALSTSKKLKTLIETPSSSHEEDQRETVPLTAPPELSKVDAAPVPQASNGPCTSKERIEPEPPDNQSTAAPEVPSWTREEDEIILLKIIQGYTSVDTFVKMIEQQLPERTSEQIRNRVEFLNEMLQRVNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK29</accession>
    <name>A0A084VK29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP002875-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00005678</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524939">
        <property type="protein sequence ID" value="KFB38323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK29"/>
    <dbReference type="STRING" id="74873.A0A084VK29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005678-RA">
        <property type="protein sequence ID" value="ASIC005678-PA"/>
        <property type="gene ID" value="ASIC005678"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005678"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004154"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB38323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005678-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="433" mass="46735" checksum="C2EF8130532F8438" modified="2014-10-29" version="1">MSVESGMEHVENAHFSRQQSEIDLLSNPIAMVTASGCETTAVRDGRTIDSPNAAGKVAPAELVQAMAVANDEGAAGSNEDGRPLGSFSDMAARMDSNKTATTTGAQTELSRSLSSNQRNSDTPNSATGSKTSGTGGAGGGGGGKRKRRRGKSQRGKSSSNRPYSKTQWKYQKASGQSARAGLVVGTGCGSNKRRLEHHYALGARRKTPFLLSDQPPLVPYNTNRFLMEDHMPQVLTPSGRTRDSSFSIDSEENYFYSLPEDEEDFLTKEFSDVYEKARCEQLESLSHAELIQEYIKLAVDYEQVLRRNTYTASAISKAAVAGSSADGSGDIAGLVGYNGPPKCDDATYKESLLEDQVRELMAENIELRRQLDQAKRMGLVVCTKSSPSYCAPDRDVEVDDRDSVVDGDDEQQPLLNGGEDLSSSPRPFVAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKI0</accession>
    <name>A0A084VKI0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005877</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005877-RA">
        <property type="protein sequence ID" value="ASIC005877-PA"/>
        <property type="gene ID" value="ASIC005877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005877"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005877-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="68" mass="7322" checksum="8FF8E30480A7F965" modified="2014-10-29" version="1">MESNSSSVGNISTGIDVRNAQGSEGKWTYEQMCRTCPLPAAAQNAIPPTGTRRLSGPLSRRLSLCRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKP8</accession>
    <name>A0A084VKP8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00005819</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKP8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005819-RA">
        <property type="protein sequence ID" value="ASIC005819-PA"/>
        <property type="gene ID" value="ASIC005819"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005819"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022076"/>
    <dbReference type="OMA" id="GRTRFIM"/>
    <dbReference type="OrthoDB" id="7737235at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005819-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38193" checksum="4625DF9660904394" modified="2014-10-29" version="1">MKLGQTEQFLKICDKVSALIWLNRMTLKGFIKQSVTTPDMGEYVIIVPRGQRLTIPETFLRPLTTSAWILVIATVLVSFLVMWNFNRYFRNDLILLPVCGIERYNLNQTHFGEKFVVLGLMVFYFLLQSGYESIIISLISDAPYHRDILTFEQLRESKLPVTVADRHDLDFFLPLFQQYQLPFQNGTTLVTANLQTNEASLHDYRSGKMLSNNPDFYDHINERNRFNILKDTISALPSSYIFSKRSRVQETFERHMHTIFEAGLISRWAQTAGIKVRVPPPSEDSELVKFGDLAPFWAVIGVGWCVSLFVFLLERFTTLQLEVKHKAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL90</accession>
    <name>A0A084VL90_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004128-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL90"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006132-RA">
        <property type="protein sequence ID" value="ASIC006132-PA"/>
        <property type="gene ID" value="ASIC006132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006132"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010515"/>
    <dbReference type="OMA" id="KDMSLVY"/>
    <dbReference type="OrthoDB" id="6620280at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF14">
        <property type="entry name" value="OSIRIS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783648" evidence="2">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006132-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="282" mass="29883" checksum="1F7CD03B3808B45A" modified="2014-10-29" version="1">MKLFKCLLVISCLATVSLAHSASATLPISSNSIDDSAPPQQQTPRAGSYLGEIKYLYKTYQDCASADVSTCLKMKLLTILDRVSRSVKDFKLSEGVKFVRDQESPVDVTPVKTEAQLEMELPRSLDEKERSLNSMLFDKVLSFFQSHTLQVKFPSSEEIKRSMDEVRGGGGGFGGAGGGGFGGGKDKDKKNGHWIMIPLLLGSTLVPLAFGALALLAGKALIVSKLALALASIIGIKKLISSGGGHHESAHEVVVSGGHGGGWGRIGSGQGLAYNGYGHYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL92</accession>
    <name>A0A084VL92_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL92"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006135-RA">
        <property type="protein sequence ID" value="ASIC006135-PA"/>
        <property type="gene ID" value="ASIC006135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006135"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006135-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8573" checksum="AF0CD2DEEBCB0568" modified="2014-10-29" version="1">MSTNRLVITLEVESVWSGRESRSGSTENVAGGGRGSDRRDHRQTLQLQARDDYPIAAYLPESAGVEFSSRFPFNRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLC1</accession>
    <name>A0A084VLC1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00006166</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAP-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524972">
        <property type="protein sequence ID" value="KFB38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLC1"/>
    <dbReference type="STRING" id="74873.A0A084VLC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006166-RA">
        <property type="protein sequence ID" value="ASIC006166-PA"/>
        <property type="gene ID" value="ASIC006166"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006166"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004701"/>
    <dbReference type="OMA" id="TFPYSFT"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783526" description="Translocon-associated protein subunit alpha" evidence="14">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006166-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="289" mass="32089" checksum="986E7F63A6163BE8" modified="2014-10-29" version="1">MKKFFVLLLLVLPAVLLTVNTGSSPFAFATEDELDEELVDVETEDAAVVADETEPEDEPETTKSPDADTFLLFTRPLHAVGSQLELPAGYPVEFLVGFTNKGQFEDFVVESVEASFRYSMDFNYFIQNFSAVAYNREVKPGHEATVSYSFLPSESFAGRPFGLNIALNYRDGRGNQFSEAVFNETVQITEIDEGLDGETFFLYVFLAAIVILLLVLGQQFLGSYGKRKRTTTTARKVVETGTTNTKDVDYEWIPSETLKQIQNSPKGGKASPKQSPRQRKAKQGLQAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLZ9</accession>
    <name>A0A084VLZ9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00006693</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLZ9"/>
    <dbReference type="STRING" id="74873.A0A084VLZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006693-RA">
        <property type="protein sequence ID" value="ASIC006693-PA"/>
        <property type="gene ID" value="ASIC006693"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006693"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011073"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020490"/>
    <dbReference type="OMA" id="RWAVATY"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783847" description="Cytochrome P450" evidence="17">
        <location>
            <begin position="21"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006693-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60790" checksum="3AC6AC9CF72DB64F" modified="2014-10-29" version="1">MLLLWALPLALYLLYRWSIATYDYFEKRNIPYVKPVPFFGQVWSFFTQEKHAVDVASEGYYMFPNTRISGVFILRTPAYLVHDPVLYKQMAITDFDHFTDHVSELSVEQDPLLARSLFFTRGARWRHHRTGLSPAFTGSKMRNMFSLLSKSASDAMERLVLFSRSEPISMELRDLYSRLGNDAMSSISFGVEVDSLTDRDNEFFIKGNRLAKVDGLPGLKILMSAIVPGLFKFLRIGILYQDVNDFYTEAVSTNIRYREKNALKRPDFIHLLLQVRKNELNCEQTDDEGLDSAGFSTPETHTLHKSDDPGEKLEWRDIDITAAAASFFFGGIETTTTLLCFASYELAVNPSIQARLRAEIDLAREELEDGITPTYEVLQKMKYMDMVVSETLRRWTPFGTTNRRCTKDYTFTNYDGTQITIEKGLNISIPLKAFHLDEKYFPDPLRFDPERFSDLTQINQDAYVPFGTGHRNCIGSRLALMQAKCFLFYMLSNFAIEPGPKLTIPIVLDETSAGLNAKHGFWMTLIPRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM44</accession>
    <name>A0A084VM44_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP009331-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006749</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM44"/>
    <dbReference type="STRING" id="74873.A0A084VM44"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006749-RA">
        <property type="protein sequence ID" value="ASIC006749-PA"/>
        <property type="gene ID" value="ASIC006749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006749"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014900"/>
    <dbReference type="OMA" id="GIERTGW"/>
    <dbReference type="OrthoDB" id="10045021at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000908">
        <property type="entry name" value="Slowpoke binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="683" mass="76866" checksum="D623F494918C2505" modified="2014-10-29" version="1">MVIFNDTTNKQPPSAARSQHQKTHPEQQQQPLESSPSQPSLQQPLQGNQREQQPQVQQPQPKEPKRLQLPLQEPVPTQLPALQEKPPADHLQQIHCQPAAPRLDTPGKLPKEGTGGPVPFSFYKTINTVIKSGRKIIVRVCEVTNVKTKLKMFNLYSTMNKRNGADDKEAKEVETTGHDRFCQERPSRSSYRRKKRKMRRAQSAAEFQEPRAEVTLTAANKRMLFRGRSISSEHDNNSETEHSERSPLVSAKLDSLAKFLFSRSLLQDSTSAAKENESPTRHSVRYQYTALDSGIGAPDRSPRERATRERAYAACQEWLQNTGGRYESIAHLDDIGSRSNKHWFLLNDCTIRTDRLMTLLPLPPDCIALEELPPSECPQGVLMELLGSLQHPYIYPVLDLGFFPSDSHHYASLVMPFNPRGSLKDLIYKSQWNEPWSRKYTRKSTCLPLSQVQRLGRQILEALLFLRERGIPSHGHLHSGNVILQNGVARLSGLENGLLGLNSRVNAVIWARSAPDIDNIDVICFGHLLFEMCAGYELTSPQPTPGHYQLDLERYPQVVDVLQMIFESPDGRYPTVEELVLCDIFRNIDLREMRGTCVPVRTTIAHPSSGDLFGPILTNCSHAVRLIYLQSFKHGLSSSTLSLLNAVRRRQGAILSGSYSEGSSPCTPPSTPRDRKTGCVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM99</accession>
    <name>A0A084VM99_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP008426-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00006419</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM99"/>
    <dbReference type="STRING" id="74873.A0A084VM99"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006419-RA">
        <property type="protein sequence ID" value="ASIC006419-PA"/>
        <property type="gene ID" value="ASIC006419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006419"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006514"/>
    <dbReference type="OMA" id="FTLHRAR"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000066">
        <property type="entry name" value="Uncharacterized protein (Fragment)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07443">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HARP" evidence="8">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="217"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="488"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB39093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006419-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="720" mass="80303" checksum="4E232CE1C12D2595" modified="2014-10-29" version="1">MSCTAEEIAEKRRIAIERLNARKNKNVNQTNQHKGPTSAADRSVAGEPQPVTSNKNPLTISSFYGNNASNAGKAASTNKTFPGKTQPYARPVQKSTPAKLAPVFIRAVTCSCSMISETRFIVETDGFNEQMIEEFKKIPSKNYVPESKKWTFELKDYNLLQERILTLNPHVVLAPIPVFVMREFASGPQPKPSRVCLNAIEPSLTSSLLEFQKEGVAFAIEKGGRVLIADEMGLGKTYQAIAVADFYQQDWPLLICSTASTRDVWASKMRQLLPHLPVHHIAILNSGQDFIGDCRVLISSYSQMERCAEKLTERGFGMLIFDESHTLKNFKAKCTTVALELAKRARRVVLLSGTPALSRPVELFTQLQMLDGRFCNFKEYSTRYCAGKQTNFGWNAMGQSNLAELNLLLARKFMIRRTKEDVLSELTEKNREAVVLDPSYLWTSKGLEDDMNCFANDYSQSKGRQRDEILIKFYSTTAEAKAPAVCAYLKQVLKEKKKFIVFAHHHCMLDAIGKSFSKQKVDYIRIDGTTRSDLRASLIERFQTKDSCRAAVLSLKACNAGITLTAAQLVLFAELDWNPSTLAQAESRAHRIGQMDTVTVRYLLAKKTADDIIWGMLQKKQKTLTKAGLCNEDFSDASHAQAASDAGNIEPFLQKTIASPGGSKAGTLDSFVQRSKPTTIQQPTKVEERLIEPDVQTKESNLSGFLDHDEDDDELAGLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMJ0</accession>
    <name>A0A084VMJ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006522-RA">
        <property type="protein sequence ID" value="ASIC006522-PA"/>
        <property type="gene ID" value="ASIC006522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006522"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="117" mass="13112" checksum="1B4E59C5442677E6" modified="2014-10-29" version="1">MESVQPEHNPFDVGSRSVLKSSIRPPTPTTTTTTTTAPKTANRVPATQRPTASYRIVYPASCDASTSGEWTHMQTDHIRQRFPEGAQTWREMHHRYHKAIKDALVSDGKGGLIFVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN47</accession>
    <name>A0A084VN47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006818</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014688">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006818-RA">
        <property type="protein sequence ID" value="ASIC006818-PA"/>
        <property type="gene ID" value="ASIC006818"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006818"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783872" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006818-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9020" checksum="99874D4D434044F0" modified="2014-10-29" version="1">MLVKMLVYVTLAVVLLAVPFCRAQAMDLDLSSGVQQKCIVPPDEQGGAEGCGGGKGKIPTRIASYAVSLGCRGVDAVLNENVLSPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VP82</accession>
    <name>A0A084VP82_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00007140</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01014985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VP82"/>
    <dbReference type="STRING" id="74873.A0A084VP82"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007140-RA">
        <property type="protein sequence ID" value="ASIC007140-PA"/>
        <property type="gene ID" value="ASIC007140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007140"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022486"/>
    <dbReference type="OMA" id="ADDCPLF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759868" description="non-specific serine/threonine protein kinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="711" mass="79363" checksum="61034F8A8CF48FA0" modified="2014-10-29" version="1">MMHELMLMLFSSPLEQGILTSAVPTPKTPIYQRYTTALQNDPRCSQEVALGRRIGLYRFCGDIGRGNFSRVKLAVHQLTKDKVAIKVVDTSRLDAKALRMLSREVSTLECVYHPFILRLFEVIETLGKIHLISEWVQGGELYNRITDVGPLKEPHAALLFQQLLLAVKHLVRNSYAPSSTCFVHRDIKAENVLLVSEERIKLADFGFSTQLVNGPWQHLDTFCGSPPYAAPELFSDDHYIGGPVDIWALGILLYFMLEGCMPFKAPTVPLLRTAVLKGEFVISTSLSVPCCRVIQRILVHTPSRRPTIEQLLDCQWFRYAQEHATQLGRGGPQANSQNTTAQSSKPNHVPRRRKGLFWFLPTPRERLSSTESNASSRDISSAAKNNQLDHFHHHHHHHHHHPNQPTTSSSTKSSASRDERLANPEIPNLRTIACSTKRATSVLEENFLHPFKAAADSVQDGVTPIVADRPPNQHPHHIKDLSNDVSNNNIINNNSSNSENYNNNMHSNGTEPPGSVVAANGNSRESAGSQERKTRRFSFGRTLKKRIGPMELVTTESLGGGPDGSGIGGSQRVNLREKLHRTIDDEHGRFVMYPTVAVSSEGNRHLHPLETETRRLMKALGINGEMIARAVVNGPRSDIIGVYRIIMHRLQREQARSRLAATNGGAYEFLELKSIYPTGSAGRWPNGDTGRSTANSRRHIDQNRGRICAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQA7</accession>
    <name>A0A084VQA7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007688</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQA7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007688-RA">
        <property type="protein sequence ID" value="ASIC007688-PA"/>
        <property type="gene ID" value="ASIC007688"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007688"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007688-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7398" checksum="EAD7FD0E529351BA" modified="2014-10-29" version="1">MAQCSTWASKHIRFKTYGKQHHLWERRKQQDVSALPRHPISDELLTDPIAENLRKWPAKGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQV8</accession>
    <name>A0A084VQV8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00007846</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015333">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQV8"/>
    <dbReference type="STRING" id="74873.A0A084VQV8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007846-RA">
        <property type="protein sequence ID" value="ASIC007846-PA"/>
        <property type="gene ID" value="ASIC007846"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007846"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001955"/>
    <dbReference type="OMA" id="GAHNRMV"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783934" evidence="7">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="68"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB40352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007846-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="313" mass="34359" checksum="1B4838882D5D5030" modified="2014-10-29" version="1">MRFNMEKGVVVRLLAVGVCLLMLAEADAARIEIDWKRVVPVEELDQYWARLPSELQVFRNASHKVGRITNGQEASPGQFPYQALVLSEYGALTTLCGGSVLTQHFILTAGHCVMLDQSTMAGGGTTIMGAHNRMVVEPTQQRIRYSRNSIFVHPQYSAGNYRFDVAIIRLGTTIVFNEWVQPVRLPARSDTRLFEGTIGTVTGFGRISDSTTTFATILRYTSNPVLSNEDCLGFWSSLLVEPQNVCLSGAGGRSACNGDSGGPLTIRETHRTIQIGVTSFGSGNGCMRGTPSVYARITFFQDWIRANSDYVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR38</accession>
    <name>A0A084VR38_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC101003906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007912</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525013">
        <property type="protein sequence ID" value="KFB40432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR38"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007912-RA">
        <property type="protein sequence ID" value="ASIC007912-PA"/>
        <property type="gene ID" value="ASIC007912"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007912"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007912-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11109" checksum="4B94F9C025238B3D" modified="2014-10-29" version="1">MESKGQRATGRATTTGHFRWLTGSVNTITAHPPCPSVSGAENAVIAVMADGRRTGRRFARTCLLALIYTVLSVLAVVWSTVWIGGLRPAVNLVFLPRKTKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR81</accession>
    <name>A0A084VR81_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">CCAAT-box-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007962</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015528">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525019">
        <property type="protein sequence ID" value="KFB40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007962-RA">
        <property type="protein sequence ID" value="ASIC007962-PA"/>
        <property type="gene ID" value="ASIC007962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007962"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007962-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6570" checksum="FE9AF4A1438EE316" modified="2014-10-29" version="1">MMMMVILLGTSKELPAPRRVVPFRGIPALNGTVECLNKGGTLIGIDALRQTGWDDTASIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRF4</accession>
    <name>A0A084VRF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002174-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525025">
        <property type="protein sequence ID" value="KFB40548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008060-RA">
        <property type="protein sequence ID" value="ASIC008060-PA"/>
        <property type="gene ID" value="ASIC008060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008060"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016823"/>
    <dbReference type="OMA" id="SWEWNSP"/>
    <dbReference type="OrthoDB" id="7764931at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008060-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="375" mass="41051" checksum="D5E88474CCD3A7EA" modified="2014-10-29" version="1">MVKHTGGKNTSGTPARLKANTKHSDTRSNDDSCDVSPSQGADYSPMISLTQDNAIHAINGVSWKWNSPQRFHGQIPLKAGDVGKKTQKPLQKPLKHSEPPPVEAPKEATGFNKFISKLNLIMGKENVGENVGSAEPASLSVERSDTTEEQYFHTAEQSPCEGQVHSEDSAEDIFEHHCIDVVEDEYGFIVGVEKRRISESSDTFDSQPFDDELDDSKLDRILIEASQTVEQKLNNPSLPPPTVIPNRRQSNTNVPFEMNDSDMDGFLLQASLMVEEKLSDSSQDSASHKPAANVPRNSAVAIPPSHSNHPPVEVERKQAQPSADASKQGAVGGTSEIAMSEDELKALLEKKRQEALIRLQNNRLKRAMKGTNSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSH4</accession>
    <name>A0A084VSH4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008458</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525051">
        <property type="protein sequence ID" value="KFB40918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSH4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008458-RA">
        <property type="protein sequence ID" value="ASIC008458-PA"/>
        <property type="gene ID" value="ASIC008458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008458"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008458-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11868" checksum="C6E93D86981CDD62" modified="2014-10-29" version="1">MAFVRLKNYSTDEGPRIPRGELANDDTFSPASLADYRCSCVTAPTDCAARDVWFIKASARRKLTNRPQGVSKDCSRIETLSSTPSRGIILQWTSSTTTRQQPVASVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT08</accession>
    <name>A0A084VT08_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008560</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008560-RA">
        <property type="protein sequence ID" value="ASIC008560-PA"/>
        <property type="gene ID" value="ASIC008560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008560"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6225" checksum="340BE0AA1E4F38C1" modified="2014-10-29" version="1">MWQEMEIGNTSCVNICKGYPTSWLKEVLASVDCHPFGVSFVAHVGILPDDDDELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTN3</accession>
    <name>A0A084VTN3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00008809</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01016368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTN3"/>
    <dbReference type="STRING" id="74873.A0A084VTN3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008809-RA">
        <property type="protein sequence ID" value="ASIC008809-PA"/>
        <property type="gene ID" value="ASIC008809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008809"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004152"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07141">
        <property type="entry name" value="ALDH_F1AB_F2_RALDH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008809-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="518" mass="56836" checksum="D33D78B65B184277" modified="2014-10-29" version="1">MFRLVKSASVCRAFSAAGLGARNYSIPAPKSSPEILYTGIFINNEWHKSASGKTFPTINPTNEKVIAEIQQGTKADIDQAVVAARDAFRLGSPWRRMDASNRGRLLYRLADLMERDRVYLASLETLDNGKPYFMSYNVDIPMAINNLRYYAGWADKNHGKVIPMDGEFFVYTRHEPVGVCGQIIPWNFPILMAAWKFGPALATGNTIILKPAEQTSLTALYLAQLTKEAGFPPGVVNVVPGFGDAGAALVDHPDVDKVAFTGSTEVGKKIQQGSGLGNLKRTTLELGGKSPNIILSDADMKHAVETSHFGLFFNMGQCCCAGSRTFIEDKIYDEFVERSAERAKKRTVGNPFDLTTEHGPQVDRAQYDKILSLIDTGKKQGARLVAGGSKVEDLPGYFIQPTVFADVQDDMTIAREEIFGPVQQLIRFKSLDEVIERANASDYGLAAAVFSKDIDKVNYLVQGLRAGTVWVNTYNVLSAQAPFGGYKMSGHGRENGEYGLQAYTEVKSVITRIPVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTR0</accession>
    <name>A0A084VTR0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008965</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525091">
        <property type="protein sequence ID" value="KFB41354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008965-RA">
        <property type="protein sequence ID" value="ASIC008965-PA"/>
        <property type="gene ID" value="ASIC008965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008965"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006677"/>
    <dbReference type="OMA" id="SIGVQMC"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="173" mass="18368" checksum="BAF3479E78E3F6DC" modified="2014-10-29" version="1">MWNKLFKSKSKSSKNLSNRSCSGTGLSAADPAAGGPSSSVAQFEQYGSSVGVAPEPVRMRSRSAVRDPDALDLATSHRDSIGVQMCGIPMRRSKLSSAFKSLSLKRSASKSRLKLAPQGSTAPDGSNPPAAPLLADEYDVLVAGKRASLRPCKSGTNQDHTPGAVERRRRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTX5</accession>
    <name>A0A084VTX5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009024</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTX5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009024-RA">
        <property type="protein sequence ID" value="ASIC009024-PA"/>
        <property type="gene ID" value="ASIC009024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009024"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009024-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="52" mass="5710" checksum="CE96DA9E4AA48741" modified="2014-10-29" version="1">MHRQPRYTAQASVASLLGLPEKPLKCLIGVIIRSSALQRDDAHQLRASGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU21</accession>
    <name>A0A084VU21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009056</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016628">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525098">
        <property type="protein sequence ID" value="KFB41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009056-RA">
        <property type="protein sequence ID" value="ASIC009056-PA"/>
        <property type="gene ID" value="ASIC009056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009056"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6655" checksum="ED7A040471125217" modified="2014-10-29" version="1">MLPLPELDQLLLVRPRRWRLLFAALPSTPSVGGVFIAVLKLFLSLLVAKPKVEFPTTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUY3</accession>
    <name>A0A084VUY3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009424</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525151">
        <property type="protein sequence ID" value="KFB41777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUY3"/>
    <dbReference type="STRING" id="74873.A0A084VUY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009424-RA">
        <property type="protein sequence ID" value="ASIC009424-PA"/>
        <property type="gene ID" value="ASIC009424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009424"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018049"/>
    <dbReference type="OMA" id="NHYHDLV"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="202"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009424-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="427" mass="48153" checksum="D51561BFEBC336F3" modified="2014-10-29" version="1">MASPLEHFVNHVRAQSSAGNLRELAEYLVESSELVTKNGNILDNVLETLDVQQHSLGVLFVLAAKFNDSSVYETENVLRSVREFITLCNGEQVRHAPQVYYELCHHLTNALVKTKQHIIQGIHVLAQAVEKIRLFNSQLTPIHADLCQLCLCAKVFNPAIRVLDIDITAIATTDDNNADTKYFLLYYYYGGMIYAAVKNYERALYFFEVAVSTPALAMSHIMLESYKKYILVALILHGKVLPIPKYSSQVITRFMKPLSHAYHDLSTAYNTSSSDEVRTVVNKFRDVFLRDTNMGLVKQVVASLYKKNIQRLTKTFLTLSLADVASRVQLSGPAEAEKYILNMIKSGEIFASINQKDGMVVFKDDPEQYNNQEMFDKVQAEIGSVMELNKQVLKMDEEIMLNPVFVKKSFGNQEDDGIGCTSKAYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVB9</accession>
    <name>A0A084VVB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000682-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009474</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVB9"/>
    <dbReference type="STRING" id="74873.A0A084VVB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009474-RA">
        <property type="protein sequence ID" value="ASIC009474-PA"/>
        <property type="gene ID" value="ASIC009474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009474"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018654"/>
    <dbReference type="OMA" id="GYETMLQ"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19687">
        <property type="entry name" value="bHLHzip_Mlx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF25">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009474-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="248" mass="28334" checksum="F9342935696F4C13" modified="2014-10-29" version="1">MDMKMEPSSPPEKDRSMHSRCSSAGSIHTPTSSAHNTGMYTIAPIALEDEEDSGDNKSSTMSYKERRREAHTQAEQKRRDAIKKGYDSLQELVPTCQQTDASGYKLSKASVLQKSIDYIGYLLQNKKKLEEERASLQKEVMALRIIQKNYENMLQHQQTSPGRTEARLSDDIKFQVFKAIMDEMFLTFEQLPMNDFAELTSGVIPWLEEHCKPHLLREVVNRMLTNITANYATECAQDMPTSRDMNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW70</accession>
    <name>A0A084VW70_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00009890</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525170">
        <property type="protein sequence ID" value="KFB42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW70"/>
    <dbReference type="STRING" id="74873.A0A084VW70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009890-RA">
        <property type="protein sequence ID" value="ASIC009890-PA"/>
        <property type="gene ID" value="ASIC009890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009890"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021563"/>
    <dbReference type="OMA" id="RENYICC"/>
    <dbReference type="OrthoDB" id="7755329at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009890-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="582" mass="68193" checksum="CE4B3AA9032FA979" modified="2014-10-29" version="1">MTLRFRFLVYRSETLLNYFQDLQHFTPSGVCQSCFEELNTFLAYRKRLNLVLRFVSSLAHIAKGETNVLEELVRDHHSDLRSLLQQLKILQKDELVVQDLLAEFHQYRIGWLKEESGKQNEADHLDNPRTVVLETIERRAGLPEENMPSVDKLDSTSENEEEPVDEINVKLDDLSEAEQFAKQSDHSYGMLLNVSFVDYCSDEETIEQPQEAVNQSDGTDVIEASRETLSEYGEVRQAGDDKKGYQQCKSCKFRTRCGTTFQLHLEKHLNEESEPWLCKRCNLTFDGKRELNQHKRSTHRDYMCDTCGMAFDCKFSLRMHRKRHEEVRQYKCEYCPVAYFTMPEMTLHVRQAHLKAFEVKCSVCALPFRTKQSLDQHMKTHTSVRTHTCTICGFSFKSHTHLSRHMKGVHQGVQYTCEHCNTSYRRKDKLRLHMERTHNSYNAAEKLEKHKTHHSNPKELQCGTCLGAYLTQKEFDEHLCITYRENYICCNRDFKYQSFYNKHMLLVHGEHTNVRVKPTDGLLIGQFRAMRRQEIRCPNCGQEFPTRTQKNNHVKTCSTAVYEEQYIDEQPDVNQCRSGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWJ7</accession>
    <name>A0A084VWJ7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00010034</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525179">
        <property type="protein sequence ID" value="KFB42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWJ7"/>
    <dbReference type="STRING" id="74873.A0A084VWJ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010034-RA">
        <property type="protein sequence ID" value="ASIC010034-PA"/>
        <property type="gene ID" value="ASIC010034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010034"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010486"/>
    <dbReference type="OMA" id="IVGHISY"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000018">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784131" description="Cystinosin homolog" evidence="12">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010034-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="383" mass="43610" checksum="86FE74521279B053" modified="2014-10-29" version="1">MCALLWLSVVLTVATGVGANFANLSLSIEPQSIVVTFGENVTFTVEANGYTPVPIEVKFYRPEEICSNQTISYAEGWHNGSTSILFQPSKQGRFIVKPLVEPAQIVDDRRFFALIKVAMHQPLIIVSLLIGWTYTACWSTGYYPQIWLNYRRKSVVGLSFDFLYINIVGHVCYAVFNAFLYWNSHVENEYYRRHPFGLNPVIGNDIGFAMHAVFGTGFTILQCRMYDTGGNSVSTPAKAIISVYMMIITITFSAAALRLMHWLDFLYIMSYIKLSTTMIKYFPQAYMNYRRQSTEGFEILNRLLDLAGGLFGILQMVINAWNFGKFPETTLLSISQAHLTRVCVKSFQMIGGQSVVIRSSLGWAFFSILFDLVFMFQHYILYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWK3</accession>
    <name>A0A084VWK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525179">
        <property type="protein sequence ID" value="KFB42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010040-RA">
        <property type="protein sequence ID" value="ASIC010040-PA"/>
        <property type="gene ID" value="ASIC010040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010040"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003990"/>
    <dbReference type="OMA" id="YYTHPTI"/>
    <dbReference type="OrthoDB" id="8186940at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF21">
        <property type="entry name" value="AGAP004005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784134" evidence="2">
        <location>
            <begin position="17"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010040-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="525" mass="58458" checksum="67A21909528963A7" modified="2014-10-29" version="1">MLVVLLLVSLLSPVLSSDVVENSTSTSGATDEGRFLVRGKPILVYPPTAPTRHQLISGVGVPVVGLPHSVVMGWVLKAQYYLPSLPKDYEPVNVENWNDSRRALPDRFRRGTVERYEVDNVSIRVEPLPVEEESKNAQESYLEEDDDDEDDLEDNLQSLKNMWLKSNVEQNETENHKESTKSGVPPPSGASSSEGYSAANSRWNVYKSIELLSNGYGFGGHVCVLRSICEAAEAQFTHTGGVFAELLHIVFSPSTTNEPVSEHRDNEYYRAEQLGRNGAPCADIFRECSTSLLDMFSGVHDLYSASTVVSDFIPWLIVPETAPTRHQLISGIGIPVGTPESITSGWVMKAQYFLPTKVDDLKPELYWTDEEDEQILGQPADDGVLWPAPKEIDPAQLDGYSAKESRWTLYRALEKLSENYGLPGRPCVLRSVCEAAEAQFTHTGGIFAELLHIAFTPSSTTEPLSEHRDNEYFRAEQLGRTGAPCERIFPECAHSLLDIFTGVHDPNTNEMRLLHDEVKAFLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXB2</accession>
    <name>A0A084VXB2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP011512-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010318</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017906">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525196">
        <property type="protein sequence ID" value="KFB42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VXB2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010318-RA">
        <property type="protein sequence ID" value="ASIC010318-PA"/>
        <property type="gene ID" value="ASIC010318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010318"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019440"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010318-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="185" mass="21415" checksum="A996CBF8EDF3F6C0" modified="2014-10-29" version="1">MMHFPGREADDERFFLXXXXXXXRTFVNLVSVPSVAKVVMLQRKPFACQSLHHGECSCWIGKLYNQSDATRERWARIQTQYIQVEKEVAESPEFRGLDEFAVVYQPWSLNVTMEMNGKEVDYSLLSYDCFHMSQKGNAYAGTALWSNMLEPVGKKSSNWRPIFKSFKCPTKEAPYLYTYDNSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY20</accession>
    <name>A0A084VY20_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010617</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY20"/>
    <dbReference type="STRING" id="74873.A0A084VY20"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010617-RA">
        <property type="protein sequence ID" value="ASIC010617-PA"/>
        <property type="gene ID" value="ASIC010617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010617"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003637"/>
    <dbReference type="OMA" id="NDETTHC"/>
    <dbReference type="OrthoDB" id="7722701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010617-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="36943" checksum="A6772BDED67290CC" modified="2014-10-29" version="1">MASHIPDPQRKAVSYRSLLFAAPEKNNTHIGATWNALDPEQMRFVYSRCFEDNLPAGPKRAVYVKNWIQWQLEPNDETTHCFAKCVLEGIQLYDPVAKKFRSKRITIQHEAFKAFTGAKDDEVARYKAAVASLKVGSGSCSDVFNTYSPVLKQFHDVSQLVYLSVSAVAAKIYEADPNVKRKGESFMEYCAKRAWKGKNKDDECKARKYGLTGSNELKQAVDCIFRGFRYINENGFNPDEIVRDFKLINKANLEPQVRSILSKCSGDKAYDFYSCLLQSDVKEEFKNAFDFRELRSVDYSYLVVGNVYDPAKVKAEMAKADAKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY29</accession>
    <name>A0A084VY29_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP008276-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00010627</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY29"/>
    <dbReference type="STRING" id="74873.A0A084VY29"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010627-RA">
        <property type="protein sequence ID" value="ASIC010627-PA"/>
        <property type="gene ID" value="ASIC010627"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010627"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007459"/>
    <dbReference type="OMA" id="PGVYMSV"/>
    <dbReference type="OrthoDB" id="7759914at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784261" evidence="6">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010627-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="272" mass="29105" checksum="5D2547971E94A848" modified="2014-10-29" version="1">MDSSITNVLLLVLAVVSCGPAGSCAKERSNLIVGGFRVGIEEVPYQCAIFRDKEFKCGGSIIGPHWIVTAQHCAPDTRAERYEVVVGVDTPDSGQLLPVDAVYLPADNPDLTTFDIALLRLARRLVFSARVSCIPLWSSKKFPAPGAAGYISGYGKTLERSLDTPLKAAVVAVLPQKECFSFYPDAGQVKPYQFCAGFEGGMVDTCQGDSGGPLVVNGELAGVTDWGIGCARALAPGVYMAVSSFSDWVHQIVGEQRNRKHRVLCADKHPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYG1</accession>
    <name>A0A084VYG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP008842-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00010676</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYG1"/>
    <dbReference type="STRING" id="74873.A0A084VYG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010676-RA">
        <property type="protein sequence ID" value="ASIC010676-PA"/>
        <property type="gene ID" value="ASIC010676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010676"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015995"/>
    <dbReference type="OMA" id="TTYVNAE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF291">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02016">
        <property type="entry name" value="AQUAPORIN4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010676-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="14266" checksum="9BEB5905FC7EB154" modified="2014-10-29" version="1">MIPSHAATPTEVVGGLGVTGIAPGLSAGQGVLVEALITFILVFVVHGVCDNRRSDIKGSAPLAIGLSITAGHLAAIKYTGASMNPARSFGPAVVMGNYTDLWVYWVGPIVGGIIAGALYRLFFKVRKGDEESNSYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZQ5</accession>
    <name>A0A084VZQ5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Restriction endonuclease subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011256</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525255">
        <property type="protein sequence ID" value="KFB43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZQ5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011256-RA">
        <property type="protein sequence ID" value="ASIC011256-PA"/>
        <property type="gene ID" value="ASIC011256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011256"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9596" checksum="90A65A25DDF8C925" modified="2014-10-29" version="1">MLLVFSVVGRMLQHQWKIIRGRQQLLQRVRLPGGWIPLLLLTRQVRGRIIRGRPHLLQRVRLPVGRFSLLLRERKRCLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W074</accession>
    <name>A0A084W074_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00011559</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01019092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W074"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011559-RA">
        <property type="protein sequence ID" value="ASIC011559-PA"/>
        <property type="gene ID" value="ASIC011559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011559"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010901"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903313">
        <property type="term" value="P:positive regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000001">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="14">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="12">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="12">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1149" mass="127501" checksum="7B6BA26CA111AB24" modified="2014-10-29" version="1">MSVDAYDGTAGSQSLTFVDTEENYFVGADSQGTEYDFRDFTIPSQSQTQASQLDHLGSSSQVNGFGRRIGVDATKLSGITSAIGELQFEEEDDEIDPGENKDLPPHACRYCGISEPSTVVMCNICKKWFCNGRGSTSGSHIVNHLVRAKHREVTLHADGPLGETVLECYSCAVRNVFVLGFIPAKSDSVVVLLCRQPCAAQNSIKDMNWDQEQWKPLIADRCFLFWLVKIPTEQDQLRARKVSAAQINKLEELWKENVDATFQDLEKPGIDKEPQQVQLRYADGYQYQNTFGPLVKLEADYDEKLKESQTQENIEIRWDTGLNKKTIAYFTLAKNDGDMKLMHGDELKLRYVGELHKPWSCVGHVIKVPDNYGDDVGLELKHNHQAPIECSSNFAVDFIWKGTSFERMQQALRKFAMDAKSVSNYIYTRLLGNVRPDGTEEVAGVRRSSRSATSTELDSGSTGNGQXXXXXXXXIVYQLARLNSGPILVCAPSNTAVDQLTEKIHRTNLKVVRVCARSREAIDSPVSFLALHNQIRNMAQNSELKKLQQLKDETGELSLSDERRYRSLKKQAERELLEAADVICCTCVGAGDLRLQRIKFNSILIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVALGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCADERKLKVDFPWPSLDCPMFFLVTQGQEEIAGSGTSYLNRTEASNVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSKLYQEIEIASVDAFQGREKDIIIMSCVRANEHQGIGFLNDPRRLNVALTRAKYGIIIVGNPKVLAKQELWNHLLNFYKDKKVLVEGSLNNLKESLIQFTKPKKLINTLNPGSHFMSNAMYDAKEVLGAGFFDRSNQPSTSYGHNPLLGYNTGALGTYHHQGGFMDHPSHGSAATGATGAVNTPLDAFMRKMHDPIGYISPQRSHQAAGNMPVPVGMFINMSNVPPRFYQQQQQAAMQAAKQTRRPVVGKTAGQLLSATGNAVAAGSTSSKPNRPRPIGPPSSSAGQAARAGAGGTGSLTQGMSQNMSQPGFSLSQQPEFSQDYMGEYQSQMDNILSQDSHYNSQTGPADRLMFELPSNSQFSQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0U5</accession>
    <name>A0A084W0U5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00011687</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0U5"/>
    <dbReference type="STRING" id="74873.A0A084W0U5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011687-RA">
        <property type="protein sequence ID" value="ASIC011687-PA"/>
        <property type="gene ID" value="ASIC011687"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011687"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005677"/>
    <dbReference type="OMA" id="QGRDAQI"/>
    <dbReference type="OrthoDB" id="7255276at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784047" evidence="3">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011687-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12062" checksum="93F17E8BD18F1B04" modified="2014-10-29" version="1">MKTIIALVFVIALALASPLTPPRQGSFEAQPSSILKFENENNGVDGYKFAFETSDGHQRQEQGELKKVGDEEALVVRGSYSFTGPDGQVYTVNYVADENGFQPEGAHLPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2C6</accession>
    <name>A0A084W2C6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012311</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2C6"/>
    <dbReference type="STRING" id="74873.A0A084W2C6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012311-RA">
        <property type="protein sequence ID" value="ASIC012311-PA"/>
        <property type="gene ID" value="ASIC012311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012311"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008908"/>
    <dbReference type="OMA" id="GVKAHFF"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KR_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF748">
        <property type="entry name" value="FI23927P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012311-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="314" mass="34109" checksum="783E898F60A1E832" modified="2014-10-29" version="1">MQSLQNIGQTPYQKALSGKPRSSGSQSNPLDVVKFIAMALLDVLTFFVLLVPLTVNAIVELVRQAPKKNISGWTALVTGGANGLGRDICLQLAQAGCHIAVVDLDATGGEQTVADIRKHGVKAQFFKADVSSYEAVSAMKGEVNAKLGPVDILVNNAGVLPLMSLREGTPDDLKKVIEINLLSHLWTLRLFTNDMIERKRGHIVAIASIASYLPIERIIAYAASKYGVRGLMGSFASELHIEGVDEFVKTTTVYPSFIKTRAELMDVLKQFGIKHRVPILKSETVARATVNGILYNKMHVYLPKAVGPIVGIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2J3</accession>
    <name>A0A084W2J3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00012222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB44437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC012222-PA"/>
        <property type="gene ID" value="ASIC012222"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012222"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017794"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB44437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012222-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="225" mass="25128" checksum="73991E2D39929313" modified="2014-10-29" version="1">MNRLFGKAKPKEPGPSISDCISGVDQRAEAIDGKIKTLDNELRKYKDQMAKMREGPAKNAVKQKAMRVLKQRKQYESQVENLRNQSFNMEQANFAHQTLKDTQATVAAMKDGMKSMKKEFKKINIEEIEDIQDDMADMLEQADEVQEAMGRTYGMPELDDDELQAELDALGDEIALDDDASYLDDVVKAPEAPDKEPGADSVTNKDGILVDEFGLPKIPASVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2W8</accession>
    <name>A0A084W2W8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005485-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00012443</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2W8"/>
    <dbReference type="STRING" id="74873.A0A084W2W8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012443-RA">
        <property type="protein sequence ID" value="ASIC012443-PA"/>
        <property type="gene ID" value="ASIC012443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012443"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012624"/>
    <dbReference type="OMA" id="ECNVETH"/>
    <dbReference type="OrthoDB" id="3565419at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012443-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="706" mass="81667" checksum="0604A734161D2B12" modified="2014-10-29" version="1">MEMQCRLCLGQTSTKLELSLANEKMRLMVDSVFNFKIKSVAHLPENICLKCSSTVQEFYQYSKKVQSIQQLLEQEHLAEFETVIVEDIKIGSDCEVDHQLNDQSDTIDESVMLHGDSDGQLSSGEARSNDSFDSQEFQECNVETHDDAPKAPSENEKEFEQQVQADGTKLQDRFLRCELCDRLFSNSKHFKTHQSEHQKKECPICGKNLYTKYLKKHIANVHQSKPAAGKKRHEKVQLPASQYERDRMIDLFIGIRCDLCQFGIYKTFADLQMHYRTKHGVQGYVRCCGGKLDTQRAAAEHVLVHQGVFACKYCDKTFLSKRSITLHEAAQHPIGDDSESRVLHCRLCNLTFTSEEKFIRHRNNHENNEDCRICGKTVRKSYLKKHFNAVHADPSKKRNTQLERKKQAISYDQIIRDHLGLRCELCPPEATQNFNEFDSLRTHYRTDHSMRGYVRCCGKQFFIRSLAVLHITAHKRNHRCHLCDKTFSGHSNMMLHISLVHASDNPEDRSYNCDECDSSFPTKPLLQAHRMRHKRTACSYCGKTFLTRCLKEHIAAKHAMKKHMEEHQSTGTDKHQCPFCLKWVKGKKYLRLHIRCLHEEKGQSFNCDLCEHVSSSSQGLISHKQRMHRESSDELKCEHCGKILKSAKSLREHIALHTGEKLYTCEYCDKKFVSNANYYAHRKKNHLKEMQAEKGTNSASENSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3E5</accession>
    <name>A0A084W3E5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012657</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3E5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012657-RA">
        <property type="protein sequence ID" value="ASIC012657-PA"/>
        <property type="gene ID" value="ASIC012657"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012657"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012657-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="8002" checksum="A6C57D2E2A32115C" modified="2014-10-29" version="1">MRSFRTGFRFDSQIDRSSKPTRSESIAKKWVDLNSGRSDQVVNKIDQMDNLKGWGKQENVALREISPGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3E7</accession>
    <name>A0A084W3E7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004396-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019962">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3E7"/>
    <dbReference type="STRING" id="74873.A0A084W3E7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012640-RA">
        <property type="protein sequence ID" value="ASIC012640-PA"/>
        <property type="gene ID" value="ASIC012640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012640"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020658"/>
    <dbReference type="OMA" id="HSEMFAG"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000004">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="312"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012640-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="477" mass="51798" checksum="54C374690E7977C3" modified="2014-10-29" version="1">MSSFALRLAPRFAGKSANQLLAAAAAQKKTYFTYSNQISQPLERQPKYTTAEEAVKVIKSGDIVFAQGAAATPITLLDAMTKHGMENNLRDITVTHMHTEGPASYCKPECKDVFRSKSLFMGGNVRAAVADGRGDAVPIFLHEIPLLFRRKLIQPDVAIVSVSPPDQHGYCTLGTSVDCVRAALENSKVIIAQVNKQMPRTFGDGIIHESHFDYAVNVDIPLPEHGGHAMSEVETKIGKLIAENLVEDGATLQMGIGNIPDAVLNALHNHKDLGIHSEMFAGGVVDLVRKGCVTNDKKTYHRGRIVGSFLIGTKKLYDFVDNNPFIEMLEINYVNNVGIIARNPKMTAINSAIEVDLTGQVCADSIGTRMYSGFGGQVDFIRGAAEGFDGKGKPIIALPSVTNKGQSKISPILKPGAGVVTSRAHVHYVVTEYGIANLFGRSLRQRAYALIQIAHPEHREALEKAAFERLKTMPTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W446</accession>
    <name>A0A084W446_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP006051-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">PPR_long domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00012926</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020275">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W446"/>
    <dbReference type="STRING" id="74873.A0A084W446"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012926-RA">
        <property type="protein sequence ID" value="ASIC012926-PA"/>
        <property type="gene ID" value="ASIC012926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012926"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023209"/>
    <dbReference type="OMA" id="ITDQEAG"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF6">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="134"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012926-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="669" mass="76729" checksum="9FDAA1DA9D0AB1A6" modified="2014-10-29" version="1">MSSLVINTIRRQCLSQFRGLFLRRPSTVLSRGLRVSYAAVSQRNKTIKDDFSLLEATNNPDQFGTLSPQVDEPETLDEGDLREEDFLQNKPSPSQKLSVRQYADLIKDHLKNNRIREALDVIEVRMKQDRVKPVNYLFNLLIGGCARVGYSKKAFQLYNKMKQHGLKVTGGTYTSLFNACANSPFLGDGLNRANHLREVMLEKGYEPNESNYNAMIKAYGRCGDLKTAFQLADEMVARRLCIGTDTFNFLLQACISDHEYGFRHALLVWHRMHRMRIRPDRYSFNLLLRCVRDCQLGDLETTEQVIEQILSDSIGSRSQVQLPIGEEKEQQTAETSVMQLPTEVDSPSEVVTIRQELSERLQHEGAPDLLSPAPHLGSLVKLGEVRKPEDRLLLLGGSSNVFAEMKRCGVEPDIRTITELLDVIPPTYAAEKQLLATIKQLKIRCDVDFFNILIKKRSMRFDYEGAREVLYMIEAANLEPDIVTYGVLALGCQTQEEAKSLLKMMHDADVRMNIQILGAMLRQGCAKKNFRYVTEILNIVRRERLKPNEQFLGHLEAFSKVCEKQDRDYDAKPRKKGREEFKMEYNRYRMQLDAWREHMGLQGLALDQALGIVREHPWEQFKEPQAEGFEKTKNPKLRHKHKRQHSIRKVDVDAIADQEEGTKGVGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W481</accession>
    <name>A0A084W481_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP005656-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00012965</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020285">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W481"/>
    <dbReference type="STRING" id="74873.A0A084W481"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012965-RA">
        <property type="protein sequence ID" value="ASIC012965-PA"/>
        <property type="gene ID" value="ASIC012965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012965"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013429"/>
    <dbReference type="OMA" id="WCLIAGE"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20651">
        <property type="entry name" value="CYP15A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB45025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012965-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="504" mass="58012" checksum="1AD4D44A4A698908" modified="2014-10-29" version="1">MLAILLGIAVALFCTYLINEFRRPANYPPGPPWLPVVGNTPYIRKLARQYGGQHKVFELLGKSYQSDVIGLKLGREYVVVALNYTAVSEVHRNDVFAGRPDNFFIRLRTMGTRLGVTCTDGAFWAEHRSFVTRHLRQAGYGRQPMQVQIQNELNELVDVIRERRGSPIWPGSILSTSVINVLWTFVTGTRIPREDDRLQRLLTLLQDRSRAFDMSGGVLSQLPWLRFIAPEWSGYNLLRRFNKQLIEFFTPTIEEHHRNFGEDRAGDDLIYAYIKEMRERKDDPETTFTDLQLTMIILDIFIAGGHTTSTTLDLAFMMMRLRPDIQARVRQEIDARLQTDELPQQTDRSQLPYTDAFLLEVQRFFHIVPVSGPRRTLAECSLGGYRIPKNTTVLIGLKTVHMDPEYWGDPEVFRPERFLVESGSDMKTHPHTDRLMFFGIGKRRCLGEVLARACLFTFFVGIMQKFELLEPVNPQPGMEPSTVLRPGITLSPKPYDVVFKPRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W519</accession>
    <name>A0A084W519_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP001518-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020453">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ASIC013260-PA"/>
        <property type="gene ID" value="ASIC013260"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC013260"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017502"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019402"/>
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    <dbReference type="OrthoDB" id="10072641at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
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        <property type="entry name" value="Znf318-like"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="PANTHER" id="PTHR15577">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN 318"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="477"/>
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            <begin position="1"/>
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            <dbReference type="SMART" id="SM00451"/>
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    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="KFB45313.1"/>
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            <dbReference type="EnsemblMetazoa" id="ASIC013260-PA"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6W1</accession>
    <name>A0A084W6W1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP002352-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00013938</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p53 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6W1"/>
    <dbReference type="STRING" id="74873.A0A084W6W1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013938-RA">
        <property type="protein sequence ID" value="ASIC013938-PA"/>
        <property type="gene ID" value="ASIC013938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013938"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017637"/>
    <dbReference type="OMA" id="CPTIERR"/>
    <dbReference type="OrthoDB" id="5915660at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF16">
        <property type="entry name" value="P53 PROTEIN LONG FORM VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="13">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013938-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="380" mass="42274" checksum="A619E754CBAEEA58" modified="2014-10-29" version="1">MMFGNDDEMLKFGNEPYPVKGEMKPFAHTSFADHTSKIPELEDLPNEFYNFNVELKGEGSKAWAYSNKLKKLYVKKKQALTVSVSHRNTLPDARLYLRVMLICSSPQDVHRPVERCQHDISKDSVVSEDLKYHVVRCLNPEAAYIGKAGGVAFKDRLAMTIKLQGVGEQVTPVSLEFLCQNSCPTIERRATSLVFTLEDEHGAILGRNSINVKICSCPKRDMDKEEGKGAAGSAVGGKRKHDAQNTSTTADDQPPRKLTRQSSLSSVRPTRSVTSTNQHELQVPSTSGITPFDCVKKETPYVPVSRSSSTISNTAVENDSTAIAVNLRLPDIATAVEVVEYAFKHISADMVRCGNEEKRNRLATFLAHCRRMKSKYSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W754</accession>
    <name>A0A084W754_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ZHAS_00014022</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01021109">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W754"/>
    <dbReference type="SMR" id="A0A084W754"/>
    <dbReference type="STRING" id="74873.A0A084W754"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014022-RA">
        <property type="protein sequence ID" value="ASIC014022-PA"/>
        <property type="gene ID" value="ASIC014022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014022"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018284"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KFB46048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014022-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="340" mass="38504" checksum="2A3B3C109AFEFE57" modified="2014-10-29" version="1">MENRLNRYEKIDFLGEGQFATVYKARDVETDEIVAVKKIKIGNREEAADGINRTALREIKLLHELQHENIIGLLDVFGHKSNVSLVFDFMDTDLEIIIKDQTIVLTPANIKSYMIQTLKGLEYLHMHWILHRDLKPNNLLISGTGVLKIGDFGLAKFFGSPNRINTNQVVTRWYRCPELLFGARQYGVGVDIWAVGCILAELLLRVPFLPGDSDLDQLTRIFQVLGTPTDANWPDVNSLPDYMQYKFFPPIPLRDIFTAASDDLIDLANKMLALCPLNRCTCTEALNMPYFSNKPAPTVGPRLPMPASYNAANRQEKKPSLKRKLLESIDGGTVPKRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7I6</accession>
    <name>A0A084W7I6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7I6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014182-RA">
        <property type="protein sequence ID" value="ASIC014182-PA"/>
        <property type="gene ID" value="ASIC014182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014182"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004242"/>
    <dbReference type="OMA" id="IPLMANC"/>
    <dbReference type="OrthoDB" id="6760534at2759"/>
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    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
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            <begin position="234"/>
            <end position="301"/>
        </location>
    </feature>
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            <end position="379"/>
        </location>
    </feature>
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            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="692"/>
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        </location>
    </feature>
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            <begin position="507"/>
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        </location>
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        <location>
            <begin position="354"/>
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        </location>
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        </location>
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    </feature>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KFB46180.1"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014182-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="998" mass="105318" checksum="7172E4A5ED3FE5DF" modified="2014-10-29" version="1">MPRYFDRGDQGTQGKPMLEKWNASRKAQSGLRKLQGVEREMQGSYHANGGTTTSIVNGTIRATSPGGTILSLSQEPPLLQNPENVVPMSETDKFERSYQPNVALVPRKTILCGKDSSTTASMVRREHEKASDRSVIKCELVQIKQESPPTPPAASSHDQTGPVVRSAVIKCDVQIKQERPGTPPSVHHDHDDGRNTPSPGPRGHLPVSPPSSAAHLHHLHHHRQGAIAYSTIISTKQQKHQHQGLVSSMPYGGSSGGSNSNSPVTLPPDAIQQHHSSGSNEITSSTSPLPPPMNGCAVNGPEKPKLVLIKEPLSPPLMRPGSNAASARHSPHSHVLLQQQQQQAQRQQEHREQQQLVVGGHQQLSPPPPSHHHHHQVSELHHQPLYLHNHHHHHVLHHHRSHHSGAPTMTTSVAGGGGGGGSSIVSGTIIHKNGIPMVGNSEFELSTDTDDDSQTGEPDSSNAPSTVELIGEVLKEVEPETKQRILDIFQGLLRESRLEHQRLLMEIGAKEDQLVEFQRQNDHLQQRVHQLQHELDRALLKIDALNEQHHLQQQQLHPMLVRGGGGGAGGESSTSSTPPSPLSLVSNGSNSSMSSNHLPQPVNQQLIERRNSFPERSVAITKPPKKMRRHSPEDSPTVLMLASPPPPPPPPPPPPVPAAHSQTPSSVVGLTSTLLPACLSITATTVSVAPKSASQHHLPDPEASSLLSAGRSEEVRAQISVTPVPLSPSTQQSHHRKTLSSSSSSSAPSPPPPPSSATNVPASPTTITATNSNTVVTPRATTPSAECPPGSNPSSGGGKGSDAINNTPSDNISTHSTVVMVVQAAGGGTSTSPGSSPPTSRSRPTSVSPTGNGVLRGGEENDDAGDDNGDEHDMMMDDDDDDEDDEAEHHRLRESRRRRSTGGGSSDEGVECTGKTGTGSGTVLSPTIGADGPPSKAASLNHKQTADDGPGVGAGSKTSASPSALSNQENDSPNRANGSSSGGTNSSTGSSGRSTDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7Y6</accession>
    <name>A0A084W7Y6_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ZHAS_00014322</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021323">
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    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC014322-RA">
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        <property type="gene ID" value="ASIC014322"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014322-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8977" checksum="CE8EB6DF4CFE84D8" modified="2014-10-29" version="1">MFHSTHPGVGFYGRRALEQFGAMSAYKINNGHLRRRKVIQLVQTADLKDGQMENKRSDCYTTSEIQSLLLRRRPLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W818</accession>
    <name>A0A084W818_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptide ABC transporter</fullName>
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        <name evidence="1" type="ORF">ZHAS_00014341</name>
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        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ASIC014341-PA"/>
        <property type="gene ID" value="ASIC014341"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014341"/>
    <dbReference type="Proteomes" id="UP000030765">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014341-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10665" checksum="5E98815D61E56587" modified="2014-10-29" version="1">MARCWPGKDIARNVRCVSPRFQHRLGLHRTTFSTPTPTTVPDSQPVIPCLLRSVLSLARFSWRLLLAGRRSDGLGGFGYHPCDEEGRIPQSGGDCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W947</accession>
    <name>A0A084W947_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP013463-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014745</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021602">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W947"/>
    <dbReference type="STRING" id="74873.A0A084W947"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014745-RA">
        <property type="protein sequence ID" value="ASIC014745-PA"/>
        <property type="gene ID" value="ASIC014745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008368"/>
    <dbReference type="OMA" id="LTISTHM"/>
    <dbReference type="OrthoDB" id="7784786at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="906" mass="101989" checksum="DF409D09F626742F" modified="2014-10-29" version="1">MDVPSLGGLYSIFELACKTYGKHDFISACLDEPAPDIKVRANPATLEYPIHLAVRSMDKRNLEALLSGGPENSSQLVKQQCKNRTALFFLFERLNSSNEKCGFECMKVLLENGADINTANGNHVTAVERLLEGNESWRRRFVEYCLNTGKVLLNPPLTSKIQRAFPGITLPHVDGTRYQILMLKMESKTDEEFIASFEQEASKGDITSAEVESLLWLAIQLGRLNVVQKLVDYGTNNRQSAADGQTDHRLEMLSNSLSVCCKYGNVPILQWLLKEIPEEQSDWINKNPLLCSLTIQINGNVDKVHCSFFKCMEELLKDPRVRVNETDSQRFTALHYAVKYGLEHVQELLLEKGAYLGGEDLFGRALICDINPFLLRRHLNRCVTDNGTSPDDQDYNIKLNFQNFQSPTRDDEMLPIVRSPTRDDEMLPIVRLAQLPDGRQLLKHPVIASIVLIKWLRISVFFYLNLLICCMFFFSFTAFMVFFYSDKPSNVNKWYSLGPAIVGLAYITLREVAQFALNARQYFKSLENYIELMLVVSSVTALTLHFTTGNENIRKSAEIFAIMLSAVEFTVLLATIPRLSFCTHMVMLKTVARNFIQCLALYSAILIGFGISFYTLFRGSSGNASGGEPKNATSPSVAPNNASTTEELNKFKEFNMISLALLKTTVMMTGELEAGDLRLDQSWGYYALFSIFLFFVPIVLYNLLNGLAVYDAMAIQTESELIAIRQKVFVINQCEASLKGFNGLCNIWMRFFGEQPYEMMKNFEYIVIQPNHGNKIQVPTKASNATNQLSNEVTVSNGTKPANDASDAEEGKIELLQHSFEVPPELPLSDLSGTIDPVIVTAARGILCSKEMDSANPDLQLQQIIHHLSEEMTKMNNLLVARHQYDLAFYQSGNRQSTTTPNNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9S6</accession>
    <name>A0A084W9S6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014985</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021871">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9S6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014985-RA">
        <property type="protein sequence ID" value="ASIC014985-PA"/>
        <property type="gene ID" value="ASIC014985"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014985"/>
    <dbReference type="OrthoDB" id="8067516at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014985-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9615" checksum="1339BEF2D580CFF5" modified="2014-10-29" version="1">MAAFDFKTINAVVPSFDGKPENVKMFVKAIKIAKELAKDNELMLVRVLETKLTGKAAQTMSEDIMKVDEFIAEIKKRFEERQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9Y6</accession>
    <name>A0A084W9Y6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP007023-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015046</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525326">
        <property type="protein sequence ID" value="KFB47030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9Y6"/>
    <dbReference type="STRING" id="74873.A0A084W9Y6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015046-RA">
        <property type="protein sequence ID" value="ASIC015046-PA"/>
        <property type="gene ID" value="ASIC015046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015046"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004905"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042676969" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015046-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="102" mass="11808" checksum="49D04B13465C1208" modified="2014-10-29" version="1">MAHRILGWLTLLSCYAYDAAVATIHGILFLDSNWEKVSSTAHKNTHISALAYDEVLKKLYFSDLDHTEYLFALDYDNNATEWHKVTKLLLKSNKTNCRKHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WA80</accession>
    <name>A0A084WA80_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015173</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022049">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WA80"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015173-RA">
        <property type="protein sequence ID" value="ASIC015173-PA"/>
        <property type="gene ID" value="ASIC015173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015173"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015173-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="7939" checksum="1C0F4982F4E3F25A" modified="2014-10-29" version="1">MVSIPPEEGRGEWLKAGNHLRIISSSFFIQKREVPRGGQGVERVASSVVQNVNPIQEKSLMRNFRCTISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAC2</accession>
    <name>A0A084WAC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022068">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01022069">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525327">
        <property type="protein sequence ID" value="KFB47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015098-RA">
        <property type="protein sequence ID" value="ASIC015098-PA"/>
        <property type="gene ID" value="ASIC015098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015098"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020947"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015098-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="136" mass="15847" checksum="979A53CD80E34FE1" modified="2014-10-29" version="1">MNPNFNDKWRSPGKKPAKGVDASFNYNLHPTGHRRSRYTPCTIINYLGLAASFEALAMEMQRIAVEKEQRENMEHRERVEEALKLLRRDVRHSRTELEVLANASRPRDGIVPADFRFKILDSKEELDKLELRLGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAG6</accession>
    <name>A0A084WAG6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Bifunctional acetyl transferase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015233</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAG6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015233-RA">
        <property type="protein sequence ID" value="ASIC015233-PA"/>
        <property type="gene ID" value="ASIC015233"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015233"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015233-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="66" mass="7293" checksum="9CC3688A2457F25D" modified="2014-10-29" version="1">MKLNRVFVCFMHRIGRRDGVLSESQTQTTFGTEMMPVMMRAMDGVDDGHDDMSSTVFDSPGSSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBE4</accession>
    <name>A0A084WBE4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011458-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00015500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBE4"/>
    <dbReference type="STRING" id="74873.A0A084WBE4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015500-RA">
        <property type="protein sequence ID" value="ASIC015500-PA"/>
        <property type="gene ID" value="ASIC015500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015500"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012860"/>
    <dbReference type="OrthoDB" id="8116123at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042282">
        <property type="entry name" value="FKBP6/shu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674:SF1">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015500-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15116" checksum="271D548E20E9BB57" modified="2014-10-29" version="1">MALDASFVELEYGGGANEPDYWASQSYAKAKETVAEIRNTAKTAYQRHQISNAIENFKTAVHILRKCQLKNDAEQKEQEETLIAVYTSLAVCYNSWHTPEAAFNSVNEIRRLCDINQNAKVLYQEGKALLKLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBU2</accession>
    <name>A0A084WBU2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015732</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022455">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525332">
        <property type="protein sequence ID" value="KFB47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBU2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015732-RA">
        <property type="protein sequence ID" value="ASIC015732-PA"/>
        <property type="gene ID" value="ASIC015732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015732"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="12108" checksum="51B25738705DFB17" modified="2014-10-29" version="1">MTPLFGRVDFALNFLPKYFVFNKFITKSCHQPFILSELVSIYLALETLPLAASIEPPVLVSRSVSAKNGFIVKQHGKPVPLLRIYGRGQGSKDHLPSTVMSSSSSSSPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCA0</accession>
    <name>A0A084WCA0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525334">
        <property type="protein sequence ID" value="KFB47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCA0"/>
    <dbReference type="STRING" id="74873.A0A084WCA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015892-RA">
        <property type="protein sequence ID" value="ASIC015892-PA"/>
        <property type="gene ID" value="ASIC015892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015892"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010069"/>
    <dbReference type="OMA" id="CAKECSM"/>
    <dbReference type="OrthoDB" id="7720602at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="169" mass="18886" checksum="719AD717E792893A" modified="2014-10-29" version="1">MPEFDVKKFVKGAGSTLSRVVQLTEEKLGTSEKTEMDARFEHLSERSDSAKLWTEKIVKDTEAAIVPNPANRVEDFIFAKIEKQKPKRLCNLEYLGLDMIEAGGEFGQDGPYGSALIKVGQAEQKLGSCERDFIGSAGMCFIQPLKKFLDGEMKTITKEKGILESKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCB9</accession>
    <name>A0A084WCB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015916</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCB9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015916-RA">
        <property type="protein sequence ID" value="ASIC015916-PA"/>
        <property type="gene ID" value="ASIC015916"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015916"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015916-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="74" mass="8517" checksum="B74CF2062DA8C203" modified="2014-10-29" version="1">MTTVKTAGVGDAFFQNVALVVEHHLPRFLLDCPLVWRKEFRLSSMSPMSRMRYLVRHQTFLSCNNACDKLSAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCG7</accession>
    <name>A0A084WCG7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015970</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022667">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525335">
        <property type="protein sequence ID" value="KFB47911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WCG7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015970-RA">
        <property type="protein sequence ID" value="ASIC015970-PA"/>
        <property type="gene ID" value="ASIC015970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015970"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="21926" checksum="37E95314F7483EC1" modified="2014-10-29" version="1">MHVDAGHGKCYPCCWMLLISPGSVRTRNTTTTNHASRSTQRRRIDCLAAAIVPSRFISFLHIILKPNLPLFNARSNQPTPMPVTRRLRLFCCRLPRPKLDGIKIRSLAVFGLGPACSSVHCDYMLHFDLSAAKRAGCMRRESIGFCGFLHDHKGPRTGGGEEGKQNQSVAFIFFLVVLCVSLSWMLSTCLHPVDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WCY4</accession>
    <name>A0A084WCY4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00016049</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525337">
        <property type="protein sequence ID" value="KFB48078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WCY4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016049-RA">
        <property type="protein sequence ID" value="ASIC016049-PA"/>
        <property type="gene ID" value="ASIC016049"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016049"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022307"/>
    <dbReference type="OMA" id="CPMQISR"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000287">
        <property type="entry name" value="tectonin beta-propeller repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="815"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB48078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016049-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1345" mass="149052" checksum="1A2D090B22A4D4F7" modified="2014-10-29" version="1">MPSTLLFANSNEGRVYALSTSGSAWREFLYLGLEFKKISVVPHFMWAIGGDRQVYVHVHGLDVPIRLKEEAYENERWLPIEGFSNRLLPTDRFHFSNADGTVDRNIEKIRLPSMAWQWEGEWQLDLSLDGQPLDHDGWTYAVDFPATYHPQKNWKSCVRRRKWVRFRRYCALNSWCAVAPLHKDPTQEPFIDVSIGGANVPGASPGLLLVWAVTAHGRVMFRSGVSTTAPEGLRWTAVTTPSGCEVSQISVGATGLVWAVLYNGRAIVRAGVTRDALTGNTWLEVKPPGTNLKISQVSVGTNSVWCVTNDNHVWYRRGVHGEASGVSEDAAIGTGWVEMVGNISHISVAANDQVFAVGSEDRALYFRSGVSASDLTGKKWRLIQLPMQLSRTSSNFSFSSRQSGNSSPTTTKHRSLNSLYKERLQQETGNGSGGGGGGAGGAGTTGGIEETSRSAPTANVKNRPELWHKPELSPDAIVTHLEGAKHHVGSLVESKLAQKPVSLESVAGTSVPVSNEVYEISGKQLKNSRAWSPVRSVGSVVGTEAHPETDSSVFEGETSRDSGVFGECEDHGGSQNWTDCEVLWVGCSAGAVTVDPAMLPNWFHDSFSQNASEELSQSWRLRLLDDLKKRLPAKEMESGAYAHYEKAIEMSSWVKSGEARCAKSGHPFEDCLIELEWVNNQGTGPDSGTLTVLNSDGITTKMQFSLSEITCIMCCSEPGSPRVAIHAPRLPPGSSPLKLQFSGDTDLEDWISHLTSVCCQINEVQGRPSARSVWITSGLGDVFVFDPINLEAQQWNEDAKSYRLQLDMKAAETPYLTSLHNGMIIGSRLEITGFIYDDADQVRFDLQAHPTVRMRHKMETQRNIPLHINPRFNEKLTVFNSMSASAWSEDEIRDKLVSFAPGAEFKLEIYSDTDGFRVQVNGTEHPKFHYRSGLAPDTVCSLYSSGRVKILHIVYDSPKIVIPLRDVYWRQIGGHMKRVVASRATGVVWGLGYDNTVWVYTGGWGGAFLKGLETSNQGINVMTDTQNYYIYENQRWNPLSGFSSTGLPTDRHMWSDVTGKHKRSKEHAKLLSMHWQWISDWLVDFHNPGGVDRDGWQYAVDFPASYHAKKQFTDYVRRRRWYRKCRLTTSGPWQEVGNTKIVDVSLQLDSDDPDCTITVWAIAANGDVLYRRGVYQSQPAGTGWEHVPCDQPLTSISIYENKVWAVGKNGSAFLRCGISLENPLGSKWQLIEPPGGVSFKQISVGRCGIWALDTAGRLSVRKEINGTFPEGSHWQLLQNILNDPPHYEGNSGFKNVSVGEHVFAVSQSGYVCKRSGITPLNPAGTGWILGIQANWNFVNVTGFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDC2</accession>
    <name>A0A084WDC2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP005422-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00016335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01022985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDC2"/>
    <dbReference type="STRING" id="74873.A0A084WDC2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016335-RA">
        <property type="protein sequence ID" value="ASIC016335-PA"/>
        <property type="gene ID" value="ASIC016335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016335"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012440"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016335-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="156" mass="17657" checksum="E3A00758E482518C" modified="2014-10-29" version="1">MTELENINPNVYKKCEDRKLTIDDENEDVVDPFDEREVFDLIRNINDPEHPLTLEELHVLEQSLITVDNEKNSIDILFTPTIPHCSMATLIGLSIKVKLLRALPPRFNVSVEINPGTHASEHAVNKQLADKERVAAALENTHLMEVINQCISAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDF0</accession>
    <name>A0A084WDF0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Light and oxygen sensing histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016366</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDF0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016366-RA">
        <property type="protein sequence ID" value="ASIC016366-PA"/>
        <property type="gene ID" value="ASIC016366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016366"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016366-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="114" mass="12757" checksum="8979340D59C20533" modified="2014-10-29" version="1">MRRRHLESHPTVRGVGNKKCTTLEGRLWHAFRNSIPGEDNDTSDRVDFLEAVSNGSSCELLMTFHPGGHLLSTGRARKLGVHQAASCRLRGNLCVVTEMRFHPFACKMAVERPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WG45</accession>
    <name>A0A084WG45_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP009811-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525343">
        <property type="protein sequence ID" value="KFB49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WG45"/>
    <dbReference type="STRING" id="74873.A0A084WG45"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017189-RA">
        <property type="protein sequence ID" value="ASIC017189-PA"/>
        <property type="gene ID" value="ASIC017189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017189"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013942"/>
    <dbReference type="OMA" id="CRLYEKN"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017189-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="500" mass="56489" checksum="36D21114C3394F54" modified="2014-10-29" version="1">MNEADIPIDIHAGKLLDWLVSRRIVDKNWHLHVRNIRNKISNAITDMPAHDELLQLLSGAHINYFHCQRIVDILKTTEADTKNVFGRYGSQRMKDWQEIIKMYEKDSIYLAEAAQILVRNINYEIPGIRKQIKHLEQLSEEAEKKINDLGRSEKVVYGEYLRMCKQLDVSGNNLRQELVQKVFNDLPGMFEKVASSVGTLKKAIELYASFVGSQECLPLLRHVVAKGNTTVYEYVYGEPPLAVEEPTVKFQVQEPANEEDAGAIDFGDDGAAIDFGGENIDLDAPVELEVGDIDWGGAALEADAGNEIDFNVSLEESGIVVEEDGNAGGVAKGTEAYTVLDAPKYRENFLNDLLELQAFLKMRLYQLGSSDKVQLLSLTMMDSFPDHDEKSLTKMLAEVEVVYTGLTEELLQHLHQIKHSPEYVDILASNVQQKLTSIDKMKETAKALKEKSINFRQQSVELKPTQMKIIEQTKTLQGQIEKDISKRYKNRIVNLYGTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGB9</accession>
    <name>A0A084WGB9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB49263.1"/>
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        <location>
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            <end position="52"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="352" mass="37179" checksum="F4EE88ECB82774BD" modified="2014-10-29" version="1">MNQRSRSVTPSSFSGTPPQTMHASDASFPSSIPSGGLLPSPNSVGANSVGRPELQARNYSDFMRSLAAKYNNNNNNTNDVSNIKNSFPEPKMRFTQPKSYIEGSLSSKKGSPLTSTQVPNPSIMTSLFSGLPFQSAVFPPLIDMSSTQALVTLARAAKESDIHNILKTDTGGGLKKPSSLSRGSSPPATSTSLTSHHFPSPFATGYLPGLLPNHHLASFPSQPPPSAALGGPLKSPSRAPEPSALSTFPLDLSASTPSASKRIRLSSPTPSRHQETSPAPSSTNSQPSADGSLDLKATRKCHARVEELGAWTVDNVCDFVASIDICAEYVQVSAKCHRTARARTVSTPTRPL</sequence>
</entry>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
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        <property type="gene ID" value="ASIC017918"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS002696"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017918-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="192" mass="22111" checksum="CBE49FBB6573A06F" modified="2014-10-29" version="1">MVFGSKVVKAGGAEPDAFETQIGQAILELEMNSDLKPQLRDLHITRAREIEFNNKKAIVIYVPVPKQKAFQKVQTRLVRELEKKFSGKHVVFIGERRILPKPMRGRRDPNKQKRPRSRTLTAVYDAVLEDLVFPAEVVGKRVRVKLDGSQLIKVHLDKNQQTTIEHKVDTFTSVYKKLTGRDVTFEFPENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ76</accession>
    <name>A0A084WJ76_ANOSI</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
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        <lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
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            </authorList>
        </citation>
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    </dbReference>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018349-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="98" mass="10669" checksum="B30AF760DCDD31C0" modified="2014-10-29" version="1">MASPGECLRWPIWESTDDPSHRTMRAAKTEPSCVRVRSFAFHPLTRLVACSRFRQARVMAKAASKGGHTYPLLGSTASSGERRLEAPATTATPAAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJA9</accession>
    <name>A0A084WJA9_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Protein NLRC5</fullName>
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    </protein>
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    </gene>
    <organism evidence="2">
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        <name type="common">Mosquito</name>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJA9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018473-RA">
        <property type="protein sequence ID" value="ASIC018473-PA"/>
        <property type="gene ID" value="ASIC018473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018473"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018473-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="11075" checksum="69DD4923B3A831B1" modified="2014-10-29" version="1">MSGKPLQHSSSSSSARGSPGVMAMREINRIHKDNSRGRFVEICRCVCRYWTRILNSHRERYLPNWILQETQAQTEIRVTGNTFGDGARSTRRDNGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKD8</accession>
    <name>A0A084WKD8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Proto-oncogene tyrosine-protein kinase ROS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00018720</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKD8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018720-RA">
        <property type="protein sequence ID" value="ASIC018720-PA"/>
        <property type="gene ID" value="ASIC018720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018720"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB50682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018720-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12564" checksum="E978E6B69C4B5FE9" modified="2014-10-29" version="1">MVRLSLGRTWAPGSTFQLVFWFPPAETNLTQVSSPIPTIVVEPTEKPGTTWNLSSRYGTGGNRGVELSEDEVSPGAVFCVAQFVASRAREKNFSSSPVWVLPVHKKWQSLFPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKM0</accession>
    <name>A0A084WKM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00018812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKM0"/>
    <dbReference type="STRING" id="74873.A0A084WKM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018812-RA">
        <property type="protein sequence ID" value="ASIC018812-PA"/>
        <property type="gene ID" value="ASIC018812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018812"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017033"/>
    <dbReference type="OMA" id="HSCLRCQ"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB50764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018812-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10645" checksum="17F60C44F5303DBC" modified="2014-10-29" version="1">MDEICVISHVPPDLSVFILRVRLDCNEAWTEHACLRCQAESKKDTLGRQDCVVVWGECNHSFHHCCMSLWIKQNNRCPLCQQEWSIQRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKP9</accession>
    <name>A0A084WKP9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox protein unplugged</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00018844</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKP9"/>
    <dbReference type="STRING" id="74873.A0A084WKP9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018844-RA">
        <property type="protein sequence ID" value="ASIC018844-PA"/>
        <property type="gene ID" value="ASIC018844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018844"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000459"/>
    <dbReference type="OMA" id="MFFLLPR"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000360">
        <property type="entry name" value="Gastrulation brain homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042982">
        <property type="entry name" value="GBX-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334">
        <property type="entry name" value="HOMEOBOX PROTEIN GBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN UNPLUGGED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB50793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018844-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="263" mass="28506" checksum="15D1E9E419FF8AB7" modified="2014-10-29" version="1">MFFLLPRDMILQIDLGDSDSDACSDDEGTPNSSTRHKSGSGTEGSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLNSHGLGNRSSGGSGTGGSGPTNKIVVPIPVHVNRFAIRSQHQQMEKMNLVGPKAELRKADLGLVETGGFERFGVAKQKQQQQQQQSQHLQKLPIPPTEVPGSRSNLQPLGVPSDGVPTAGGGNGTVGLTLCSLGSPSHNPLPLPASRALNPKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKV0</accession>
    <name>A0A084WKV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP005203-PD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019089</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKV0"/>
    <dbReference type="STRING" id="74873.A0A084WKV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019089-RA">
        <property type="protein sequence ID" value="ASIC019089-PA"/>
        <property type="gene ID" value="ASIC019089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019089"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020257"/>
    <dbReference type="OMA" id="AREAHCP"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB50844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019089-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="31167" checksum="C069B38317FFA316" modified="2014-10-29" version="1">MDGINYDDIAYNFLIGGDENIYEGRGWKKIGAHTRGHNNNCEGIAFVGDYNFSDQPTEKQMDLLKQLLEYGVSAGYIMENYKMYASEHFDDTSPTGKKLIEALQKLPQFVDITNETHPAYTKAKCIFHVKLIQQFHISPDSKNFSDIGYQFLVGGDGNAYEGRGWTKQGAHTKGFNVDSICIAFVGTFIKEPPPAAQLSAARQLIQIGVENNYIAANYSLYGHRQLAPFESPGKALFDIIKTWPHWSNKLSSNSWQEPDPVKPSAKEATHRASADTTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMP1</accession>
    <name>A0A084WMP1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019541</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMP1"/>
    <dbReference type="STRING" id="74873.A0A084WMP1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019541-RA">
        <property type="protein sequence ID" value="ASIC019541-PA"/>
        <property type="gene ID" value="ASIC019541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019541"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006517"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="162" mass="17656" checksum="57E2CB1C519EA647" modified="2014-10-29" version="1">MVLCHFRATVQLAKFVASTAPANAFKCRFFSASSVALKDRLFTDKHEWVSVEGEVGTVGISNFAQEALGDVVFAQLPDPGTKLSQKDECGALESVKAASEIYSPVSGEVTEKNGAVEETPGLVNSSCYEKGWLFKLKLTKKDELAKLMNEEQYAEFLKTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN34</accession>
    <name>A0A084WN34_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP007396-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00019703</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN34"/>
    <dbReference type="STRING" id="74873.A0A084WN34"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019703-RA">
        <property type="protein sequence ID" value="ASIC019703-PA"/>
        <property type="gene ID" value="ASIC019703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019703"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009430"/>
    <dbReference type="OMA" id="ANSQVYN"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="510"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="846" mass="89856" checksum="418E3AC73433E1B4" modified="2014-10-29" version="1">MNVAGIRRNIKNIAHNYSDAQVKVREATSNDPWGPSSTIMAEIADLTYNVVAFSEIMQMIWKRMNDHGKNWRHVYKALLLLEYLIKTGTEKVAQQCKENIYAIKTLNEFQYMEEGKDQGMHVREKAKQLVSLLKDDERLKNERARALKAKERFARTASGFGSDGSIDGPTQRDPRPPNWGEGEPIAGAATSGVAGKPVSEIEFVRPQTVGEEELQLQLAMAMSREEAEQEEQKRRSDDVRLQLALSQSEQDFKKDHDPKAGPQEGSSALVDLLDISFGAASISSPAQQQPLAGPSGSAPIDPWGMPVAGGSRPTTSDPWSRTSSPPVVDPWLNTASALPPAGPSTSKPPLLGAGVGLEAWQPRTQSPSVASGSSVEGWLHNGGGAAAGMSNGTGATNGNVDPWLSKTTMAGVGATAPTTVPGADPWQANKRTTPVPVVAATADPWQPSSSAAKLDPWAPLSNNSASGSIGDLGAAFGGAVPPNRPSPVGAITSPVSDLDEFDIITKRAASTTSSSNNNNNHAASNNLNNNSSLLLGDLDPLSSSGTTSSSPSMGATTAVKKTPQSFLGENSSLVNLDNLIKPMPSGTGASGATASSTASAAAYNPFGDTGSAGPPVQKNLFHQNQPQVPSINQLKQSPFPVTLNQDPWAPVANMTAAQPHVDDIEYFPYASDLDANAINNNDTIDTTDRHTSDWRISSHSSMAQARTLGTVEHIDCSLNEENIRGDEPREEEDDIFNTNYVLSSSTAGGETGFAGGRHLSTAHLDTARPLRQLYDFHFAIDDDALEINRSPSLSTGDGHNIPTRNPGGTTLPDACHANINNNFESNLNNNNSAPWMNPQSSNPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNA3</accession>
    <name>A0A084WNA3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP007479-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019783</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNA3"/>
    <dbReference type="STRING" id="74873.A0A084WNA3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019783-RA">
        <property type="protein sequence ID" value="ASIC019783-PA"/>
        <property type="gene ID" value="ASIC019783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019783"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011520"/>
    <dbReference type="OMA" id="WGFHFFT"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019783-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="314" mass="35711" checksum="29531827C930C2B3" modified="2014-10-29" version="1">MASRTPANEAEEQVENLHTKLATIFDSPSETVPSVCYSIEISAKDDFHMELLEQLSPKPIFCSLPWISDETLRYEDNFLQAPSLRLSKELQKARYTVVNHLSCYNLTEHQVEKFLATGVRNLFIIRGDTVTPGQKFPKAANLVQHLRDREQANGGVKLTIGVGGYPYGHSQSRSDTEELQYLQAKVAIGVDFLLTQTLYDADSFFRYRERCRNVGITIPIIPGIYLPNSYQHLQAMLKITNITLPPLLRASFDSHADDTPDQFEAFVVDHFVGVVRNLVQPNDATNEPVRLVHFFTFNKLRLLQQVLFKLKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNE3</accession>
    <name>A0A084WNE3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP007514-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019828</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNE3"/>
    <dbReference type="STRING" id="74873.A0A084WNE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019828-RA">
        <property type="protein sequence ID" value="ASIC019828-PA"/>
        <property type="gene ID" value="ASIC019828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019828"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014410"/>
    <dbReference type="OMA" id="MVTVCEV"/>
    <dbReference type="OrthoDB" id="3565419at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="355"/>
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        </location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019828-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="496" mass="57209" checksum="7729C70E662EE7EB" modified="2014-10-29" version="1">MVTVCEVCYVSSEAEYLEILSEDHKEKCIVDVLSKHLPCVNLEDIENPQICLACWTIVSNFHELYNQVEDLHRPQPESCSSSDDDAEGSTKETASTGDSKHRLEKTDTSNDEVYYHQDETIDEFRFDTESVCMDDDSNGTTVEVLEEEHLDEFEPTAGEESSNEEQSCVEGPEVDNNTDEGGTNLAAESAEEKNCKDSALIEFYGLMLCEICESERMKQNLPSTAYDTFVGLKRHMLEAHQIARTYLQCPLCSKRIFLHYKLWQHIDYHDNPEKYRCAKCGETHQDLEAHMHNKHMEKQFQCTDCDRRYSSAYRLATHAKVAHSPKDVVCEKCNKVFNKYLIKGHMRSIHGEPVYVCEWCGESYRTIALLNKHNQLHQSVLLVECSVCKLKVRSNYIDRHMQLMHTERLPVECASCGKSFLNKRRLLVHQDRSCPARTYNCLTCGKIFKTVAKLNEHKTTHNDSASVHYVCPVCMDKFDSKSRLYAHHEERHKMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNE6</accession>
    <name>A0A084WNE6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00019833</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="74873.A0A084WNE6"/>
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        <property type="gene ID" value="ASIC019833"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019833"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023453"/>
    <dbReference type="OMA" id="YTHISNV"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB51740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019833-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="667" mass="76658" checksum="0BE9E8535FBC7F26" modified="2014-10-29" version="1">MAAQIDVYDVINQKECGVCLTTRPDPICWDMFMPREQDSKEMPYLVWKYVGLKFSQETGKHFICADCGKALHEFNRFYLWVHDAHLQRLAKVELAQVNPEQPHHEDVNQNGACGTEQVQFKEEPAVEAEPPHAAEQRAELKQEVSAENGFTPAPSLHPAEGRDGPTEYERESNRMSAIGSSNETEAESSQVRPIVGTPSRKRRNQEIDDEILEFYKLVCDVCDDRSEYGSMKELNQHMRQQHGEESGRVGCPQCGKKFRTRVKLLEHKHVHTRQAEAAEEEVEKVQSDQMDKEILEFYKRIVCDVCETAGTSQTGTLYGTVKELNHHMRLEHGQPAGAVKCPVCEKKIRTRPKLLEHKRMHLSNELMEDDSGKSGTAGNETGPELTEEQKQTLDREIFDFYKPIVCEICDPEKAPPGEATVEYRSLKLLNQHMRATHGLDSGTVKCQICAKKFRTRVKLVEHKDMHENPERYRCSTCQEVHQNLEEHMQNKHQEWEFKCEECGKRFPFKSRLTAHMGKVHLKKDIICEECNKPFTKFSIEKHKRAVHGATFTCENCPKTFKTRFSLERHMEGHNVEQQGPATVSCTLCNSVLKDEYNLKTHMKRIHAEQTPATCKTCGKTFKSKHSLYTHISNVCTTRQFPCTVCGKQFKKRTKLKEHMTTHARSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNJ8</accession>
    <name>A0A084WNJ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exportin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Importin-alpha re-exporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00019945</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNJ8"/>
    <dbReference type="STRING" id="74873.A0A084WNJ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019945-RA">
        <property type="protein sequence ID" value="ASIC019945-PA"/>
        <property type="gene ID" value="ASIC019945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019945"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006889"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019945-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="972" mass="109991" checksum="5C84F96803A1861E" modified="2014-10-29" version="1">MEINENNFERLANYLQQTLNPDPEVRRPAERFIESIEISQNYPLLCLHLVDRPQVDMTIRVAAAIAFKNFVKRNWGFHLENDGPDKVCESDRNGIKSLIVPMMLKSPASIQKQLSDAVSIIGKYDFPLKWPQLIDEMIEKFATGDFHVINGVLQTAHSLFKRYRYEFKSQELWEEIKFVLDKIAKPLTELLQATLGLAEAHANNEEALKVIYSSLVLVCKVFYSLNSQDLPEFFEDNMETWMKAFHGLLTLDVPCLKTPDDEDAGVLEHLRSQICENLCMYAQKYDEEFGPYMPQFVTAVWELLVNTGIQTKYDSLVSYALKFLSTVADRNHYRHLFEDPNVLASICEKVIIPNMDFRLSDEELFEDNPEEYIRRDIEGSDVETRRRAACDLVKTLSQNFEAKIIEIFGQYLQVLLAKYAENPASNWKTKDTAIYLVTSMASKGQTQKHGVTQSSELVPLPQFTQQQIIPELERSDVNQLPVLKADALKFIMTFRTILGPQIIVATMPLVAKHLGAGSVVVHTYAACAIDKILTMRGTDKQPIVTKELLTPLSAELITGLFAAFTVQGSNENEYIMKCIMRVLNTLQEASLPFMIVVLPRLTEILTVVSKNPSKPHFNHYLFETLSLSVKLVCKADPNAVSSFEEALFPVFQGILQQDVLEFMPYVFQMLSLFLEIREGKSSIPDTYLSLFPCLLAPTLWERPGNVTPLIRLLCSFVRQASPQISAEGKLSGVLGVFQKMIASKNNDHEGFYLMQNLLLHYPAEELGQSMRQIFSLLFQRLSSSKTTKFVRSFIVFLCLYASRVGPQALIQMIESIQAQMFGMVIERVFIPDINKVSGELDQKIVSVGLTKLLCECPEMLAEPYVNFWPQLLQTVVQIFELPPDESAIDGDNFIEIEDVPGYQAAYSQLNFAQSKPFDPLPDVTNVRQYLVQHLGKLGQAHAGKVGTLISSLPAAHQEALQKYCAQSGVQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNX8</accession>
    <name>A0A084WNX8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ZHAS_00020085</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01024773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024775">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01024776">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNX8"/>
    <dbReference type="STRING" id="74873.A0A084WNX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020085-RA">
        <property type="protein sequence ID" value="ASIC020085-PA"/>
        <property type="gene ID" value="ASIC020085"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020085"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005896"/>
    <dbReference type="OMA" id="NDANGYQ"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000405">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000587">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1123"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KFB51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020085-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129896" checksum="BCD285136A10308B" modified="2014-10-29" version="1">MENNRPQPSSGHRLNANDFYFGKMLGEGSFSCVYLAKEVRTSKKYAIKVCEKKLIIRENKQEYVKREREVLNRLTGKPGFLGLYCTFQDRTKLYYVMTYACNGTLLSLLSRPSFNLDCARFYAAEMLLALETMHNMRILHRDIKPENILLDQHMHVLIADFGSSKLDYQEEEELKDAAPPPSPKMSTARKHAKQVLEKAYREEDDDDDDTDDTEDVHPVARGNKRRSFVGTAQYVSPEILTGTPSSPASDLWSYGCTVYQMVCGVPPFRAASEYLIFQKILNRQVTYGEGFDPCAKALVSRLLQIEQSQRLGARDNPRYTSIRAHPFFKGIDFETLRSSPAPIAPTEETVLNGDAGANYFPEDMKPGLDDRQITRLLDFKLADLEVSDEGRTGDMDEGELYQGGGVTRSVTGTRSASSTMKHAQTKSLTDGSTSTASFDGSKNDPGPLSVWEPFTDGETILKYGYVSKRKGLFPRRRMFLLTTGPRLIYIDPVNMVKKGEIPWTATLSVEAKNFKTFYVHTPNRTYYLEDPEGFALKWCDSINEVHRKAFLNSVSDPQRVNASNLARFVQLRELHVQSLQPQLLRFEIDTTLPVERLHLEAVDLVRTKPPVIFDRSAPSASELGLSKQAPTDGDVLQGNNEANIYHVVGEEMELVVDGGADGDGGEQLTETFEVEIVPYEVYKRELAITSNVSFYGWTNLTALSIHDCQLESLHPDFLYGLTRLVRLSLQHNNIKVLPPFAFYGAPNMRLLSLADNRLLEVSYYALAGLLELRVLDLSGNNISKVSELTFPPFPKLTKLDLRQNPIEYVFDSSFAIANMTRSLFIGSDTVGLQIRTPKPFQGLTQLELLEVRNLRVDALNQYLFRGLRAVRTLRLMQGNIPFVEYDSFAEMKNLTELYASRCAIGAVSMDAFFGVKRLRTIDLSYNLLAELPVGLFDEQLQLLELLLELYLQGNRLTKLPTEFFRRLAPAVQVVRLIENPWLCSCTMVEWRQAATNRLKMASTGSYVYSNKLTPRCSDPALGIYDRTVYYVIRKNLPCNSHKTFQPARRVITQLNHRKQDTLIRARVIAATKTIPPAALRPIVSTSSASFDNPIPVVVRHYQRSPTDDKSLLYEQKRRRLQQKLHHSQRYAAPAPTGQRIVSNDIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNY5</accession>
    <name>A0A084WNY5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP004015-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020093</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525360">
        <property type="protein sequence ID" value="KFB51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNY5"/>
    <dbReference type="STRING" id="74873.A0A084WNY5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020093-RA">
        <property type="protein sequence ID" value="ASIC020093-PA"/>
        <property type="gene ID" value="ASIC020093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020093"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012734"/>
    <dbReference type="OMA" id="RVSMYFF"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785041" evidence="6">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020093-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="504" mass="56748" checksum="7C35D9B9FAD8BB94" modified="2014-10-29" version="1">MLLSKAIVLVSALCALAAVSGSPADVRAPGVKSTRMLQELQRHFVRPVVPVDFVPKEDHITGGRFRTRVDHFDPQNRDTFEFSYFSNDEFYQPGGPIFIFVGGNTALSTYYITHGLLYDTAARDHAWLFTNEHRYYGTSAPVSDYSTENLRFLKSEQALMDLIEWIDHLRNNVVMDPQAKVILLGVGYGGALATWARQRFPNIIDGAWGAGATVLASFDFQEYAADVGSLIRRFGGNDCHSLLWVAFRTAQYLMDADREETVTNLLNTCEPIEPGNLLDQETLFFHLKLAVQEAIFATQDTAKIRDVCENMLNATEGTALEDFASWLQGYYADLPCLPFDFDSNVVPGRVIEPGAPENALFGIRQTHYQRCTEFGWFLTTDADDQPFGDRVTMHFFLEACRAVFGDWITDAVVYDGVRLTNLHFGGQDPRSTNVLFTNGEYDPNRFVSITSYINPLSYAYVVPDEFLFSEIYSIGEDDSQELIAIKNSIQQYITLWQGQCLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPJ0</accession>
    <name>A0A084WPJ0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Protein deacetylase HDAC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="33">Tubulin-lysine deacetylase HDAC6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">ZHAS_00020457</name>
    </gene>
    <organism evidence="37">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="37 39" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate</text>
            <dbReference type="Rhea" id="RHEA:21548"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:21549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
            <location evidence="5">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025080">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPJ0"/>
    <dbReference type="STRING" id="74873.A0A084WPJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020457-RA">
        <property type="protein sequence ID" value="ASIC020457-PA"/>
        <property type="gene ID" value="ASIC020457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020457"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012272"/>
    <dbReference type="OMA" id="HTRSHVN"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032886">
        <property type="term" value="P:regulation of microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10002">
        <property type="entry name" value="HDAC10_HDAC6-dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0678">Repressor</keyword>
    <keyword evidence="24" id="KW-0804">Transcription</keyword>
    <keyword evidence="23" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="17 34" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="36">
        <location>
            <begin position="997"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="928"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="35">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="35">
        <location>
            <begin position="934"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00050910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00068733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00082852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KFB52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020457-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1119" mass="123796" checksum="553EFF30F2F626CB" modified="2014-10-29" version="1">MAPKNSLNVVTRSSAKQSKVRTRAQQAATEAERQERREKLYGSQTRAAGRVTLAEAKQQGKLKMSAQGAGADRGRNSSEGGDATSSDQHLKDIYHNALSVAGSVRGPTGILYDDRFALHRCLWDSNYPECPERYERVMERCKMARLVDRCTFIQPRAATEAEVLTKHTAEQIRILKETHGSQDEQQLEELSSHYDAIFIHPTSYETSLLAVGSTIQLVDSVLDGAVQNGMAILRPPGHHAMTAEYNGYCFFNNVAIATEHALKRGLKKILIVDWDIHHGQGTQRMFYSDPRVLYFSIHRYEHGTFWPNLRESDFDYIGEEEGRGYNFNVPLNATGMTNGDYLAIWHQLLLPVAAEYQPELIIISAGYDAAFGCPEGMMEITPAFYAHLLSPLLSLAQGRVAVVLEGGYCLESLAEGCALTLRTLLGDPCPALVEKLQPPTKSMRSSILNCISSHRSYWKCLQRHELYDLEDYNNINPHYNFHKVVQCYVAPAPPGPGPVRYETRNCYPVQSADERARIHERLQRLQLLTDLTVPATRVCYVYDEVMLEHRNEHEQWHPEQPERIAKIHQRLSADYQLVKRMKRLAGRPATTEELCLVHAPKHVEQIAQVGASSTLKQDADQFNSVYFHPRTEASARMAAGSVLQVVDEVLSGSARSGLCIVRPPGHHAESDAPHGFCIFNNIAVAARAAIEHHGLKRVLIVDWDVHHGNGTQHIFENDPRVLYISVHRYDNGSFFPKSADANFDVVGSGEGEGFNVNIPWNRKGMGDAEYVAAFHSIVLPIAYEFEPELVLVSAGFDAAIGDPLGGCRVTPEAYGHFTHWLSSLACGRVIVCLEGGYNVNSISHAMAMCGKALLGDPLPVLQPTSARSSNAPNASCMETIRSVLEVQRKYWRSLCSNKKLPSSQQQVLGSASLEDALEGLSIAESKLPGLDEATLPSTSTSSGQSPLSEAGGESSTNQASSSSGSSSQNPAQTLNDYLKANLEALQNEEMFAVIPRRNCPHLKLLQPETAPSAIDCRAPCSDCAAEGENWVCLICFGVYCGRYVQEHMLRHGTETVDHPLTLSFADLSVWCYGCDAYIDHPALHPYKNLVHQSKFNEPLVWSYGSDLVLEVLPTTSKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQT4</accession>
    <name>A0A084WQT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP001397-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00020822</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025723">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525398">
        <property type="protein sequence ID" value="KFB52578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020822-RA">
        <property type="protein sequence ID" value="ASIC020822-PA"/>
        <property type="gene ID" value="ASIC020822"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020822"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014831"/>
    <dbReference type="OMA" id="GHFYAWP"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020822-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="484" mass="53767" checksum="BCE206CD2D111EDF" modified="2014-10-29" version="1">MCETTVHCLEVTNVQNFETFQHPIVLLKGKVSNRCADAKLQVFSKQHQSISYSATIEDGVKRDSPGPVNFRVLLRLNVGQNDIDLVYCVGTKSLTLRYTAPSNRYTVVPLYIICAGHTGHYQSYDTDKENDCVNACRKITLSIELLQCLYAEKLHENGFGRKTFCIGSSCVPFSSSLELERSTTMTEGELWQHFASELVQCREYDLKRVKIVAFLSSTRFEGISDGDYSYENIRKKTTGHAALGGGGLALFGTGCLYTWPTTLEAVCDAFSSQRPVDCDILLDDSNYRRTYGGCYATTLGSVCHEMGHTFDLGHTPDSSIMGTGLDGIDCVFVGSRAAAGPKRLIETRPYGPSGKLTQLKRPGDVFRERLESKCNDGIFFALNSAVTLNHHRWFNYNVDNPDDNGSAMLHYAQSTRTITSTDSPIVLVELRLTSNGMMEKFWTFPRAKCPTSFTIPKLPTFVDRTLFAMNAVGCTLKIDLSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRQ3</accession>
    <name>A0A084WRQ3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00021175</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01026176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRQ3"/>
    <dbReference type="STRING" id="74873.A0A084WRQ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021175-RA">
        <property type="protein sequence ID" value="ASIC021175-PA"/>
        <property type="gene ID" value="ASIC021175"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021175"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019313"/>
    <dbReference type="OMA" id="ECFEIWR"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF39">
        <property type="entry name" value="ALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="36"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KFB52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021175-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114578" checksum="D2CB6842AF581203" modified="2014-10-29" version="1">MIFRLISVPKIFPRSRTLRKYSTQHVRHVPRSSAGPSSNEIRQQFIDYFTGKHNHRLIRSSSLIPYNDSTIAFVNAGMNQFKNIFLGATDRPCPRAVNSQKCVRVGGKHNDLSVVGTDSYHHTFFEMLGNWSFGDYFKREACEMAWDLLKNVYRIDAGRVYVTYFGGDARLNLPADEECRDIWLSLGIPKDRILPFGARDNFWEMGNSGPCGPCTEIHVDLSNEYGRTEARRHFVNAGVPDLTEIWNIVFIQYNRSHVDGSISNLPQHHVDTGMGLERLVAHLQGKMSNYDTDLFQPIFQRIQKASKKTPYSGCFTSTESQYELDTAYRILADHSRMITACLADGMFPSQNHKLRRIIRKSLALANGTFQCPQLLKETIPAVVEILGDVYPEMCTNLPATLQIIDHEQQSYNQLRSKRSTETASLLKSFPMLEESEVLEHAGLPGAIKELVQTSPTVLTGQAIHKMYDTYGLDEELLVKLGEMLKFSLDFRDYDRYVRELKDGHKHELAAKLQERLSAFHSIKQSLDEASLKPTRDERKYNYTFNQEKGVYDVAPCQTRVNLLLEDETNRLLHIVTEQSNFYCESGGQQGDTGRLVIQEGNAGETKCVDITSVSKHNGFIVHTVEKATNTLVAIGDRVVLQVDSNRRTLLTVHHTATHLLNAVVRRVVALPMCQRSSAVSEKGLRLELAISGDKITLDQVATIEAEVRAVINQNQPTSVSVCNARELDFGNITTVPGETYPDRGLRVVSVGNVSRELCCGTHAITTGELQDFAITNVTQSKSGCFTFHAVAGQAAKKVHYLGRQIQNDVEQLRQDAEQNERQEDLTIIETRMQRLKNVLLTGMDNNIHLPYCVRQRCLEVINTLYQALKNRSRESLRELIDIEMRNLIEQKPPATDRYIVHFLECSIILDEVQLSKATRYCPDRPILVISITDNQVKARATVPRSMVSERFNAERWLAEVANTFKAQTAAPKGQNATEVCNMKNRKVTKMHFESMLENALRAAKKFAEENCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS70</accession>
    <name>A0A084WS70_ANOSI</name>
    <protein>
        <submittedName>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
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                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021685-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1413" mass="151317" checksum="8051413EA8A02491" modified="2014-10-29" version="1">METVRVFNQELSGLYESKPPISKAKMASITRSAMKAIKFYKHVVQSVEKFIQKCKCEYKIPGLYVIDSIVRQSRHQFGPEKDVFAPRFARNMESTFAHLFRCPPEDKSKIIRVLNLWQKNMVFLPEVIQPLFDLANPDHPIHQQYNAQLALQEAAGANGMNAGVMGHDSPAGTSMGGGMDDHSVGGPLQMGETKQLDPNTIRQLQQFQQILMRQTSGDQAAANAAAKDQVKFNKKLLDFDYGSEEEEDKNSPSVPLSGGAGLPDLAQVPGGNIAQILSDPNVLKQLQNLQKLKQQEEKQSKLTEMRLQEEKFEKHLASVLMKLPFANECDLSRQPPIDLNAGKCPAILEPLPAGSSRGGALGGSGSGNNDRYKSSSSSSRRKSRSRSPRDRRGGGGGTGRSGRGRSHSRSRSTSPRSSRRRSSRDRGTSNKDREREKEHERERKRKGLPDMKKEHLSVCSTTLWVGHLSKLVQQEELSDTFGKYGDIVSIDMIPPRGCAFIVMNRRQDAYKCMQSLKNHKMHGRAITISWAAGKGVKSKEWKDYWDLDLGVSYIPWTKLSPSTDLESLEDGGMFDEDTMPQWMKDKSSGVGPAAVGLAPATAMGLVAAAAAAAGMLNPSLFPLAAVDTSQPPPTAMLGMGIPPFPMGAVTRLPIPMGIPMGPNMVPGLGINVPPPGIMLPGNHPPLPLGGFGVLPPPPPSSGSGLLGNGAASANLHNSGSNMSKSSADDMDIEMEDENPPNAAPMVGAGGQAAGGGGGNSAFFNQPPPPLLPPNASIPPGPPGTFFGAGAQSADGNMPDNGDGGASDDAAEGGRSRDFQRDDGRQDHRGRGGDRSRDRDQRGGAGGFGGDRGDGGGGGRRDRGERGSRWGGGGNERAGGNNFRGGANNQDDRPLSERLRELAGVLGFNNQQQQRRGGNDGDDFGNREADFTRRGGNFSQNNRFNNNAGGGGNGDGRGGAGDQGGRNQGGGRNGPFGSQQQPGRGNAGGGPGGGMFGSRSGGRNQQQQRGQFFNEDRQQQPGGFFDRGDDGNSNNGYDSGGNNSNSGNRRGGNWNNNDRGGGGRGNRDDGGRARGGRQQNNWRSGDDSAGSGGDGQRYNNGPRGGNKRGPVGNRPGGGGVARWDDDDKNWDDGGNRPTTGRQAPFSANNNNNNRRQRQNSGQEEQQGDGGSEGRQRREGQSEPEDMLGGEESSRNAATSDNDANIDGGQMMDSRRGCGGGGGGSDGENVGGRRFPRDHHRGHRNDDDPDDERPQPILYSPEPEDEAEQTNNLPANDNNADARESGMAQEESSLGASRNDRYESHRREEEDHTHGQPSAHATGSTSMAEMQHEQNDFSQREEQEEREQQQQYEEQQDHQEHHNDSVPPSSMGGDADSGPSFEQTAVEHTVTTVEDNSGNDDTAPAPESDSMLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTG5</accession>
    <name>A0A084WTG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021736</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021736-RA">
        <property type="protein sequence ID" value="ASIC021736-PA"/>
        <property type="gene ID" value="ASIC021736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021736"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7258" checksum="D8DBBF4F35C99E65" modified="2014-10-29" version="1">MGRTSPASSPRESAAHTQFASERGRGCRRPSPPPPPPAAAAPASPYLQPPTSLPPPQTTPSPPVNPPQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WU50</accession>
    <name>A0A084WU50_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00022124</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01027000">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WU50"/>
    <dbReference type="STRING" id="74873.A0A084WU50"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022124-RA">
        <property type="protein sequence ID" value="ASIC022124-PA"/>
        <property type="gene ID" value="ASIC022124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022124"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022829"/>
    <dbReference type="OMA" id="MQTECKC"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF72">
        <property type="entry name" value="PROTEIN WNT-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB53744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022124-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="345" mass="39134" checksum="5BEE6EC197316736" modified="2014-10-29" version="1">MLKYLTVLRIAMLEAEGSSVLLDPERVCESKHRKSRRLSGKLADICKNDTSLMREIHRGISLGFRECENQFRNSMWNCSWTIKRSMRRILAKDTREAAFVHAITAAGITYAVTKACTMGELLECSCQKHLKTRELHTITMLTGQEEKWKWGGCDDNVNFGVRKSKDFLDARLRRKSDIKTLVRLHNNNAGRMAVKHFMRMECKCHGLSGSCTTKTCWMKLPPFSEVGARLKEHFDGATKVIARNDGHSFMPDDITIKPPTRRDLVYTEDSDDFCEPNAKTGSLGTHGRECNITSSGVDGCSLMCCKRGQTHSQVEVKRNCNCSFKWCCEVTCSTCIDIQDVYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUB3</accession>
    <name>A0A084WUB3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00022045</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525421">
        <property type="protein sequence ID" value="KFB53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUB3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022045-RA">
        <property type="protein sequence ID" value="ASIC022045-PA"/>
        <property type="gene ID" value="ASIC022045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022045"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="120" mass="13615" checksum="CFB2D66FB45FFB2C" modified="2014-10-29" version="1">MLANLAQPSHDRQLERNCFIIIDLRQRLPDAIEFPIQFSGKLNLLRRTNARTEENFNFFITFAAFVRSDSSNSSRRAFGVLHDGPKGGKDCKRYGPEWTALEWLCSQVPASPPTGFGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUY1</accession>
    <name>A0A084WUY1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00000414</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01001953">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL640343">
        <property type="protein sequence ID" value="KFB54025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUY1"/>
    <dbReference type="STRING" id="74873.A0A084WUY1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000414-RA">
        <property type="protein sequence ID" value="ASIC000414-PA"/>
        <property type="gene ID" value="ASIC000414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000414"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006430"/>
    <dbReference type="OMA" id="VYEMENR"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001709">
        <property type="entry name" value="Elongator complex protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB54025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="26165" checksum="7EF9511AEF106213" modified="2014-10-29" version="1">MYPEHYFNPVSMDVPPAEESLMQNTLWPEIQKLYGHGNELYSIAASSDGSLIASACRATSSDHAQILLWDTKTWRIVQQLAAHQLTVTQLSFAPNDRLLLAVSRDRTFSVYEREQEGGDFKQVMRSDKTNGVHTRIIWCCDWSHDSETFVTGSRDGKAVAWSRPHAEGTDGRRGCFTSNRVLELKNESITALAFGRKKLSDDRYLVAVGLEKGIIKLYALGQWNLLLNIDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9T0</accession>
    <name>A0A084V9T0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP000409-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00000005</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523840">
        <property type="protein sequence ID" value="KFB34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9T0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000005-RA">
        <property type="protein sequence ID" value="ASIC000005-PA"/>
        <property type="gene ID" value="ASIC000005"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000005"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009660"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000005-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="71" mass="8032" checksum="80E6038C1A835545" modified="2014-10-29" version="1">MEMILAILRKKAPQFGMPKHPRTLVNTNKKATGIRKATGGTLWYNGLRHSLGVALGTVAYPELRIRWHSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAU3</accession>
    <name>A0A084VAU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP005328-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524214">
        <property type="protein sequence ID" value="KFB35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000956-RA">
        <property type="protein sequence ID" value="ASIC000956-PA"/>
        <property type="gene ID" value="ASIC000956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000956"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006264"/>
    <dbReference type="OMA" id="HEMTTRI"/>
    <dbReference type="OrthoDB" id="7786524at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="621" mass="68033" checksum="D419E67D254A9253" modified="2014-10-29" version="1">MGCASSSPLINGGGPGGVVESAKEAATKTATDVLHAGEAAIHDVGEHVKEAVQNVTHELENVLGGGKKTEKSDHINENDQAAMANGHGEGDDPSSNTDYQIIRLKGSKQNSVEETELMENMKNDLMTKAQSIGDDTDRLADDLIKETEELMRDAETGIAHHEMTTRITSAEDGTIEILNLEGNAPNSPNHSNDSLKTTSPEPEIERILAAGAEADRAPDSPKATLHSLAVPASEATRAGKDEGMPEEKPDVEEGSVWTTPQASLDSESMGSSVGEEHFRNEVLRATSIRTPGRNIGRRSPNPTARAPPPSVGRSERMQRFIFKLNSVILSDIEERVGAPEKQGIVRQLERNPEKVVELLSKSSVDRDDETEPDVDVTDDTPTGMKSRATDRTLRRQHSVSLEADTNDGSSPEEENWSDGRSREDASALESGGVQLKDISPAVRLRALMRFKSFDGFTIESSTERKKSRRRMKSLDSIDTDEAKGIDDGGQEIGEESSPDAYLDVPYDPEEEERICEELLAELRALEEADRADCNTEPNTTDSAQDDGIDGEAIISVEQEPESGPKTAWEKLQDYLQRVPKRRKCNYDLFYDSEEGILRTLFKHHKTKLLFHYSSSSSSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAX3</accession>
    <name>A0A084VAX3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00001037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01004724">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524237">
        <property type="protein sequence ID" value="KFB35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAX3"/>
    <dbReference type="STRING" id="74873.A0A084VAX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001037-RA">
        <property type="protein sequence ID" value="ASIC001037-PA"/>
        <property type="gene ID" value="ASIC001037"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001037"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004302"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="87"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001037-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="262" mass="29860" checksum="59BA45D33F5F39A4" modified="2014-10-29" version="1">MASILRSFASAVAKSGVLNANGLTRAAPAVMLRYKSTEPAAETRPTVRKPDAAARSELSDFGKYVAECLPKYVQKVQLTSGDELEVLIAPEGVVPVLQFLKDHHNAQFANLVDIAGMDVPSRPHRFEIIYNILSLRYNSRIRVKTYTDELTPIDSCNEVFKAANWYEREIWDMYGVFFANHPDLRRILTDYGFEGHPQRRDFPLSGYVELRYDDEKKRVVCEPLELAQEFRKFDLAAPWEQFPNFRNANPASEEIATKPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VB66</accession>
    <name>A0A084VB66_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00001291</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01005689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524307">
        <property type="protein sequence ID" value="KFB35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VB66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001291-RA">
        <property type="protein sequence ID" value="ASIC001291-PA"/>
        <property type="gene ID" value="ASIC001291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001291"/>
    <dbReference type="OrthoDB" id="7758973at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="35924" checksum="73F56C971079D0DD" modified="2014-10-29" version="1">MERDKRGVCPCKEGDCAVVEECEAFWKIKVKERWDFIAKNKLCKCCLKYHPTACKTVPCGKGGCNAKHHRSLHTPCVVPKRWDSGQIGNDTIDRRTYLKLVCRKTEQKSIELSVEVSSAVTKDNMSAPVAIRPSVEITTLIGSSCAPSTRPVQPVEAVDSVARETRPGWMECGDFSQQSGQFQQLGLSPISFARRDNAEICMDGALQDVPTLESPAFTNSQFRFSCEQREKEILYNLTGRDGYVLGPEQTLQNNKSTNNCFSTVIESNIPASRKVRVSFADAASMYAVSLNTTIPTTSSPSTEDISSKRWVARKCTIGSTSSTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCK7</accession>
    <name>A0A084VCK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Gag-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00002601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524617">
        <property type="protein sequence ID" value="KFB35701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002601-RA">
        <property type="protein sequence ID" value="ASIC002601-PA"/>
        <property type="gene ID" value="ASIC002601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002601"/>
    <dbReference type="OrthoDB" id="7764411at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="251" mass="27510" checksum="7833CC4A6B25DDBA" modified="2014-10-29" version="1">MNDIGALFSRSSQLLRTPPNDAASVVVADEASSSTRAVVTTPVARPTVEMGKRVANSKNWCKFVEALETAKALHEYTNGRNNDHKGIKRMVKQIVAALSAYEREQSTTEPLEGVTSVDGLVSPNPTPIGTVKRSRLLRSPEEAIEANKKQKSGLEPVVSAEGWLEGDSVYGVTRGWRTQCFHSDSFLAALSLGCFGSAPTSAAKLVRDLSDACDTTMPRRRPPSRKLRPKYWWNQAIKLLRMPQKASESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD60</accession>
    <name>A0A084VD60_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ZHAS_00002857</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524650">
        <property type="protein sequence ID" value="KFB35904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD60"/>
    <dbReference type="STRING" id="74873.A0A084VD60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002857-RA">
        <property type="protein sequence ID" value="ASIC002857-PA"/>
        <property type="gene ID" value="ASIC002857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002857"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012217"/>
    <dbReference type="OMA" id="DTKPRYW"/>
    <dbReference type="OrthoDB" id="5917019at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KFB35904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002857-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="16962" checksum="B7D01C2EA1698855" modified="2014-10-29" version="1">MSSLVRLTNAVLVRSLINHSARSARLISSSQKNRDAATIEVPKKAAAAGPAAAASSATTGKNWVSYGFDRKDETNDRSAMNASFFFSVTLCLVLGSVYWAYVPDPQLQDWSQREAYLELRRREAAGLEPISKDFVDPAQIVLPSDEELGNTEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDK3</accession>
    <name>A0A084VDK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003079</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524700">
        <property type="protein sequence ID" value="KFB36047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003079-RA">
        <property type="protein sequence ID" value="ASIC003079-PA"/>
        <property type="gene ID" value="ASIC003079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003079"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003079-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9394" checksum="1E8B9A7B41E459AA" modified="2014-10-29" version="1">MQCTIRRTTRDPGWMRSGNGEHRAEREITINDIGPTAKGRSWYQRKGKKEEEEQEDGGKTAHMHTRSNGNGRDTAKRRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEU3</accession>
    <name>A0A084VEU3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP006403-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00003617</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524780">
        <property type="protein sequence ID" value="KFB36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VEU3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003617-RA">
        <property type="protein sequence ID" value="ASIC003617-PA"/>
        <property type="gene ID" value="ASIC003617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003617"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007094"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011077"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015776"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016051"/>
    <dbReference type="OMA" id="NFAQMGH"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17082">
        <property type="entry name" value="RAWUL_PCGF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1511"/>
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            <begin position="1562"/>
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            <begin position="1766"/>
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            <begin position="1778"/>
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            <begin position="1801"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB36487.1"/>
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    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EnsemblMetazoa" id="ASIC003617-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
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    </evidence>
    <sequence length="1815" mass="190832" checksum="A143B2FCF1A90565" modified="2014-10-29" version="1">MVLLPNGDEEVVGGGQLLSSASTELASEGTPAKVFIAPSSSSSSSSASASTSDTDPTSNSKTTPVVPSSSNNNNNSTPSTTMTALMIDDEGKTAGEGTVASATVSSGPLSPYRPSRVTLGSVNACITCNLCKGYLIDATTIVECLHSFCHSCIIKHLHTEQYCPQCEVMINKAKPNIKPDVPLQSIVFKLVPELYENELRRRRDFYRDHPASAALATPAQRGEDTEHLIFSPNEQISLSLEYAESELAEDNKELLRARYLLCPAVFSIAMMKKFLVNKYGISERQFCVEIMYKVKTIVLPDYYTLMDVAYIYTWKRDAPMKYFYRIRTTETNPLELPEIPLRRSPSLITTVSSSTKPGQQQQPQQPTIGSRRSRDDSEEDDKENMHLAPLRALDISSAADGQQTEASGGALAVRPTTIATPGTPDVNGNRKMTVSANGGDSQQTPTTPTPRKNESIKLKIELNKNKYVSFLQSPQADVPLSQSSPAVSGSASGRASSPASGGRVHKSDRPDKVKRKKMDSPRTQKIQEKMDELKLKIEKIKDHGLTSVTKKKKLAPYKVELSPGIAQSESKKLHSSKSSGMSSSGKTKVKSPKSHSSSSSSPTEGPKHPIVLKIDQRSPDMATSTLKFEMTPKESKQSKTPSPPPFPPSPPSPPVKRFEDEKSQFLNSFQLAPIKTATASSPESKNKEAAPTAVSPSSSPPKSPGSDSDKFKKPKALPTLNGSPNTKSSSPPREPSTGSLKRKAKDSNSLRSGPKKQKLSDDEIKAMVEKKVAENIKSPSEHIVPPIFLKPKVPPPPPSATPQPVSSPPLPAKKDTPKSHFSTSVDSFGKSPKASESGRAKCDSPRPFLFKTPPPPPPPIVSVSNIPAVKPSQQVLPAPLPQKAEVSPGKLPSSKTTTSSPTSPKVANGGGPKAAQALAQAPARRPTVPTKLPTSHGHNSSSTSSTGNATTHNVASGTAGGKFQKPLELKRAQSNPWLNITSPTASPATEISKLRPEDLKNNVKVYGPSPPPAGPPSQSVASSSVSSTPTTVNSMPKLDGGNFAVPKPKPAPKQQQPPVSSSAVSTSVATSSSSTSAKTPVSSASGGAGVKVRPVNYLNYAMFNSKAAPAGSRTPIPSYSNSPSYSPDSPGYNPNLNISTNKFKYANPTAFSNYMQNMMSDRKPGSTSPPTPLGGASPSPTSSPSPPHQQDVLPPATKKVPSSTTTPSADRKRPASAISPDTTTKSSSPVEQPPEKQPKVQSLLNKINIPSSLSITLATEEDEVARQTARKLSENDPTNNYIEIVKLPEIPISEAVTSTDRKSPPAPAAAAPKTAPISSLSPPGPPAIQVLPVTTAPTSTTTATASPSFPPVVDTFQKKFMESINANSKPTKVPKSSSPALNTSASETTPPTTAKGSSSSGKSSTTPPPPRPSTPKVPSSGGASSKYKNPNATVLENGKVKLHNYLDVDQLVKGFNASAGANPQRPPSGSSSSSSKLMPPPPVKNNNNIPIAPKSNGSPPVPANLQRKAISPPVMRSPSSSSPSPSPMILNGQPKSKTPPSILPSMASMGPMFDIQMKSNANASSNTPLRRHSTTTNPSYMTNTPTLPRRKITPANNSTMLVPLRSSPGSSPSSVSSSASSSAQSKLMPPSRMSDFITLHPQPSPMEQAQQQHHQQQQQFNQLQNLLQNPYVAALASQFNRNQSASIAAAAQNSFYPYFLQQLSQQQQLSQSMAACPVTIGGGGGGPPGMGMGSDALTITAAQRVSSNKQSSSMPLNSLTVTAIRGSPNGPSGPSSGKNGGGGIGIGPAGAAASPKPLPRGGMGGIPGKPPGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEZ9</accession>
    <name>A0A084VEZ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP007572-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00003691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEZ9"/>
    <dbReference type="STRING" id="74873.A0A084VEZ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003691-RA">
        <property type="protein sequence ID" value="ASIC003691-PA"/>
        <property type="gene ID" value="ASIC003691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003691"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005237"/>
    <dbReference type="OMA" id="RFHDWNF"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB36543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003691-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="36053" checksum="B39C53F5238EAF61" modified="2014-10-29" version="1">MLLTIVVGSVVAVLTYKLARLIIEGGQFRKNTRCDGKVILITGANTGIGKETARELLKRGGKVYIACRSLERANQARDELVAQTGLSNIHVLELDLASMDSIRQFAQRYDSGRRFLAQEKRLDLLINNAGVMACPKALTKDGFEQQLGVNHLGHFLLTNLLLDALKAAAPSRIVNLSSLAHKYGKINRKDLNSEHSYNQVTAYCQSKLANVMFTRELAKRLAGTGVTTYAVHPGTVDTDLPRHMGSLFFLFDHKLVKPILSVAFKTPLSGAQTTLYTALDEDLAQESGKYYADCREQKLSKYARDDELAEWLWNESAKMTKLSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFA0</accession>
    <name>A0A084VFA0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein prickle</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00003699</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01012369">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524785">
        <property type="protein sequence ID" value="KFB36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFA0"/>
    <dbReference type="STRING" id="74873.A0A084VFA0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003699-RA">
        <property type="protein sequence ID" value="ASIC003699-PA"/>
        <property type="gene ID" value="ASIC003699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003699"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022594"/>
    <dbReference type="OMA" id="HRENRLY"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09415">
        <property type="entry name" value="LIM1_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000022">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033725">
        <property type="entry name" value="LIM1_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
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        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00059227"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073341"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB36644.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003699-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="775" mass="86357" checksum="A65801F5DD2086E8" modified="2014-10-29" version="1">MRNRCNNFLSVHLYFSAIPEDKVPYVNSIGERHRVRQLLQQLPPHDNEVRYCHSLTDEERKELKLFSAQRKREALGRGTVKQITTTLICERCGECASSGDMMVFASRFEPNTCWHPACFACCVCKELLVDLIYFHRENRLYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHIKHFACFECDKQLGGQRYIMRDGKPYCLHCFDAMFAEYCDYCSEPIGVDQGQMSHDGQHWHATDQCFACSTCRCSLLGRPFLPRRGEIYCSIACSKGEPPTPSDGSLPAAAALMHGHLRSARNTEQQEQVDGNEYEHTTGSTKAYRSSPSLPKSPEPLRSPEGSHHDRRDSPSHTEHSAVGSSGDQNFTDGNGNDEMTLSCYTAATSITTSLSAATGNTSTTLATTTNTIATESATANEHEVQSHGSRASSDRLTVPAVVGDTNRHRIPQCSPELNRLLHKDRSRQPLDLTDLSLSLEQHWQTERTGSETITTVMATNPAAGKTQSGSPSSPGGAQILTSSMPELNRCMQVGSPSFSSSNSPTPMGGSKNVTLGNDADEQNQNASDASHSVVELPTPPPIVIKKEVRFEGDFQDSLPRSKSHCQRNSGQRNRSAKPSKRRNDYDRYESSASTSRRQHHHSQSQQSDRHDRHGSSSTRRSPRRRRHTASQRNYASDDDELAEDETDKYRHRHHASHREQQRPVDDSDTRSICSTCSSSSSSADDDVYELPLRRTSYGGTRIHYMPNNSLVCARKRKQLQTATTGGIGGQHYEKDNKNCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFY4</accession>
    <name>A0A084VFY4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Clathrin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004052</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene ID" value="ASIC004052"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004052-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="84" mass="9293" checksum="4F21B621D7931DF2" modified="2014-10-29" version="1">MLREERFSCSLLLLSHSDPADGRLKKDGREKPSREDEHLHTRFKDSLPTGSRSMLQRQPASQPAIGPTDGGKFANLTSSVTTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHH2</accession>
    <name>A0A084VHH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004548</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004548-RA">
        <property type="protein sequence ID" value="ASIC004548-PA"/>
        <property type="gene ID" value="ASIC004548"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004548"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004548-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16591" checksum="61D8542BAA8FC16F" modified="2014-10-29" version="1">MRSSFRPEEHMPTRSCFDFSCNPCGGEDGGGAGWTNTERKKLNRWQQPAAAGQARPEQLCWSAATRPSTNQKRAFWVPVALMRLVARRLGSTFPQEVGEAGRNLRSIDDRKNAPAEAQANPAGRVLCAQMFYIQVVPILRVPKKKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VHV2</accession>
    <name>A0A084VHV2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004778</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524847">
        <property type="protein sequence ID" value="KFB37546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VHV2"/>
    <dbReference type="STRING" id="74873.A0A084VHV2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004778-RA">
        <property type="protein sequence ID" value="ASIC004778-PA"/>
        <property type="gene ID" value="ASIC004778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004778"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003233"/>
    <dbReference type="OMA" id="YHLDCHE"/>
    <dbReference type="OrthoDB" id="7740893at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="281"/>
            <end position="290"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="322"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37546.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004778-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="534" mass="59210" checksum="023ED50979250834" modified="2014-10-29" version="1">MVSDSKHKLISEFFIPDELKDDIAYCQRSLRDYVKVHQQAQVQGFLRELEDEMLAIGKDQSELVQDLTKRLRHFQRKTATERSVELEDDLANGYVAWVLSTHCELQGAQSYVPRAVSERLNESQLYQKYRLVDVGRNVSVLPDKRLRKRPVLQTSLLKPLAERTVDPGAQNHPKPFLTPSSSQAILPPLAPPAVVKVPPVSATASKRKVPPEQPPIHVKMLRSRTSTVKQEETPIKREPIEQGHEPANDSEESSPNSSNGAMSDSAAVKRGRCNLRQALSKVTKSNQHQVSPPTSTSKPTASRSNRPQPGGTLPSSPSTGKRSPSLPSSSSESSNSRASTPGVRKPPDVASDDSSNEHLLPLIEEDHPPTLPCTIDQMDQYAFLRPLGLYTIADSNLLKGRKNERKRRSCYSTERKDYHYGKLDYFEQQQLYIMPKRRPGANKRLLYTATTAEKANKNRSNPWSNGASATLPPPPPPPLLPPSLVVALTSTVVTEQSLSETVATEAPNQTVDNALEEPKNGVCCVCTKVGKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIJ2</accession>
    <name>A0A084VIJ2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Adenosylmethionine--8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004950</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIJ2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004950-RA">
        <property type="protein sequence ID" value="ASIC004950-PA"/>
        <property type="gene ID" value="ASIC004950"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004950"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004950-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="9272" checksum="9E77C4F7FCDF5DB8" modified="2014-10-29" version="1">MTIDDRLEMGRISYLSNGGLYGNRTAIAPEMYHKWSSEPLREFIGCEPGRSEEVKCSTTSLQHSWLALAEATRRRKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIS5</accession>
    <name>A0A084VIS5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005185</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIS5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005185-RA">
        <property type="protein sequence ID" value="ASIC005185-PA"/>
        <property type="gene ID" value="ASIC005185"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005185"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005185-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13280" checksum="5A4527CF65F8611C" modified="2014-10-29" version="1">MLHANVAKWNDFATRYQSAPGLQGVEPESETAILPGMILVKMIVTMMTSAAPLEFHHESQRLRDLSFGRRRPLPVWNNYVTEFFSPESTFRCQNRGAACDGTVGKTLSHPPLTFSPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIY8</accession>
    <name>A0A084VIY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP000097-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00005256</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VIY8"/>
    <dbReference type="STRING" id="74873.A0A084VIY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005256-RA">
        <property type="protein sequence ID" value="ASIC005256-PA"/>
        <property type="gene ID" value="ASIC005256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005256"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008305"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="220"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB37932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005256-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="325" mass="36254" checksum="4CC7752E28C1FC1B" modified="2014-10-29" version="1">MSANKRQPPNAVQQSSQSTDRPTNINNRDAVVTSLIAGAVAGALAKTTIAPLDRTKINFQINKDVPYTFRAALGFLRQTYVREGFLALWRGNSATMARIVPYSAIQFTAHEQWKKLLQVDLHSDTEVRRFLAGALAGITSQSLTYPLDLARARMAVTDKYSGYKTLREVFVKIWQCEGPRTLYRGYWATILGVIPYAGTSFFTYDTLKNEYYKRTGDKSPNTVISLTFGAVAGVIGQSSSYPLDIVRRRMQTTGVTAQCADQYLTIGRTLIKIYREEGLIGGFYKGLSMNWIKGPIAVGISFATYDHIKHMLREVIHVRGSAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJ17</accession>
    <name>A0A084VJ17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005131</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524855">
        <property type="protein sequence ID" value="KFB37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJ17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005131-RA">
        <property type="protein sequence ID" value="ASIC005131-PA"/>
        <property type="gene ID" value="ASIC005131"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005131"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005131-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="11892" checksum="5982F838EC215A44" modified="2014-10-29" version="1">MAKLARRATPLLFTDARVPESAARPNTSRSDASHAIIIRLDNGNAKHPPLEASDNVQPEILQFRNSASGWVPLFACHTLSVIVYGWSSTGTNRAEKPEKLLPVTRECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJT0</accession>
    <name>A0A084VJT0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJT0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005539-RA">
        <property type="protein sequence ID" value="ASIC005539-PA"/>
        <property type="gene ID" value="ASIC005539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005539"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783473" evidence="2">
        <location>
            <begin position="22"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005539-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="611" mass="67736" checksum="20ED3A9B18BDEA2F" modified="2014-10-29" version="1">MNVRKLLVLTLLAQRLVVSRQAIIPTRSSCRHKPRLQRVWRRGPFRFDIAQYEPTRWEWDKRMVRDSGRDTLERQEPVPVREHHLPKSENQPKLLWKSEHRHEDYDSLMESDDPVAVWPEPLVADRTMIVDQHDNVGTRFVKSPRNTDIGVRSVKSCEQRSPKVVEDSVEGTVRSSETPSGANICEHCGGLIKTTEVPSILTTTFDPSIIEPLDTVILLPPFEEAQSSNQILSIQPHPDTNNTMAILDVQINREAHHGKNYLSDFDNISSKQASDNDHMMLSSTSTPTTEMASNVPSEETINSTPQKPLDSLDEVTTDIPPQTTTTVCNDRFNGSQVIEVRNSAEPAKVSELENKHSSPVDVPGNFSVVTDVLTSTLTTPSSTIVQRIRQRHANSFSTPLPLQTSSQTVYESMSDDLMSTELCSIMGATRTSQQLNLTTIKTTTSTRSEGPSQGSLHENSSSYDFTQEYEASTESTTMFHGESVSTVTVPVVEPSTICSTEVQKPVSTSTIGRVETKNIVTQTASIELFGSSSTTAGDFFLPEMLPPLPPLDLVPDDDFAEAGGIWSQILKALLSLVESIFELFSDPQSNCDDNPPTLVDFGFDFSDEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJV3</accession>
    <name>A0A084VJV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005566</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005566-RA">
        <property type="protein sequence ID" value="ASIC005566-PA"/>
        <property type="gene ID" value="ASIC005566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005566"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005566-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="67" mass="7609" checksum="4B4476310F598840" modified="2014-10-29" version="1">MAGAEIAVGINKHPLFRAGPKRGLNFILEDPLLHCPVRIRDTGFFCYGQERTRKPRDFADENVILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK57</accession>
    <name>A0A084VK57_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">AT30160p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00005705</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK57"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005705-RA">
        <property type="protein sequence ID" value="ASIC005705-PA"/>
        <property type="gene ID" value="ASIC005705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005705"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005705-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6284" checksum="DFC8591176C24D20" modified="2014-10-29" version="1">MPVAIDVRRKTFDRLHRLHDDAGFCPPARPRWQTLTLTDDCIPMAVFQSLADDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKR0</accession>
    <name>A0A084VKR0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011225-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005832</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524948">
        <property type="protein sequence ID" value="KFB38554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKR0"/>
    <dbReference type="STRING" id="74873.A0A084VKR0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005832-RA">
        <property type="protein sequence ID" value="ASIC005832-PA"/>
        <property type="gene ID" value="ASIC005832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022291"/>
    <dbReference type="OMA" id="GNCAKEQ"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="297" mass="34980" checksum="95303280DEB5AFBD" modified="2014-10-29" version="1">MDSLNKSVNTSEENTRNNFEEVKNQLISKMDSMQLQLTAETKIIQEKTQTELKQLGENKKTLDMLTDSIRNISIQGKFNTQLLHMMHPVSSCRQDFNVSGKFMIQIELNSEPFEVLCEQNKFEGGWTVIQHRFDGSIDFYRNWTEYRNGFGKLDGEFWLGLEYVHQLTKNRPHELLVEMKDFHGNYGYAKYGEFEIGSESEEYKLKKLGTFSGTAGDSMQYNKNLKFSTFDRDNDPYHGNCAKEQHGAWWYFCIFGSNLNGRFQNTADRYTVMYWLHFKNDYRALSYSRMMIRDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VM02</accession>
    <name>A0A084VM02_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VM02"/>
    <dbReference type="STRING" id="74873.A0A084VM02"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006703-RA">
        <property type="protein sequence ID" value="ASIC006703-PA"/>
        <property type="gene ID" value="ASIC006703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006703"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783561" evidence="2">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006703-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="279" mass="29721" checksum="F16710EDD1CA4D79" modified="2014-10-29" version="1">MKWVLPFLSLAALANAATFVLKVAPQQCEPGDECSRFPKPPQRSASLRQDCRFIADCYDDYNYNDFPPLPLPGDTYPPLPGSDTDYTYPGTFPDYTFPPFDYNDSGSEDSEPTPDSDNSGTDESSPEPEAQPEPEAQPEPEAQPEPEAQPEPEAQPEPEPEPAPTPDVMTPGPDSDDSSPTPDSDNTVSASDTESPAPASNSDDSASESTDNEPASDSNNSETTSAPDESSSADTGTVNEETNAPSADTEPDVSLRSMPSKGRGDGSLEVRVILPPYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMJ8</accession>
    <name>A0A084VMJ8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-pyruvoyltetrahydropterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00006531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01014599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMJ8"/>
    <dbReference type="STRING" id="74873.A0A084VMJ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006531-RA">
        <property type="protein sequence ID" value="ASIC006531-PA"/>
        <property type="gene ID" value="ASIC006531"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006531"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010192"/>
    <dbReference type="OMA" id="YETERNF"/>
    <dbReference type="OrthoDB" id="14045at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00470">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00039">
        <property type="entry name" value="6PTHBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006531-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="175" mass="20020" checksum="C66476073C3EACB6" modified="2014-10-29" version="1">MPPRPLAYLTRKECFSACHRLHSPFLSDEDNRQVYGKCNNPNGHGHNYTVEITVRGPVDPKTGMVINITDLKEYMDHAIMKKLDHLNLDKDVPYFKNLPSTTENVAIFIWDSLKLIMKSPELLYEIKIYETDKNSVVYRGEKHETGHHHHQEAPKNVRPTASSETSSNLSSDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMW9</accession>
    <name>A0A084VMW9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fructose-1,6-bisphosphatase isozyme 2</fullName>
            <ecNumber evidence="8">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">D-fructose-1,6-bisphosphate 1-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Muscle FBPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ZHAS_00006669</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 24">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01014632">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMW9"/>
    <dbReference type="STRING" id="74873.A0A084VMW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006669-RA">
        <property type="protein sequence ID" value="ASIC006669-PA"/>
        <property type="gene ID" value="ASIC006669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006669"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021160"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000005">
        <property type="entry name" value="Fructose-1,6-bisphosphatase isozyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="17 24" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="25">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="26">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KFB39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="336" mass="36583" checksum="C6FFE81516C9C11A" modified="2014-10-29" version="1">MTQQGPAFDSNCMTLTRFVLQEQKKYKQATGDLSQLLNCIQTAIKAISSAVRKAGIAKLQGISGDTNVQGEQVKKLDVLSNEIFINMLRSSYATCLLVSEENDNVIEIETEKRGKYVVSFDPLDGSSNIDCLVSIGSIFAITKQANEAAEPSLADALQPGNKMVAAGYALYGSATMIVISLGQGVHGFMYDPSIGEFVLTDYNMRIPERGNIYSINEGYASTWDSSVLEYVQAKKDPTKGKPYGARYVGSMVADVHRTIKYGGIFIYPATAAAKNGKLRLLYECNPMAYLVTQAGGKAFAGKDKQILDVVPTSIHQRCPIYLGSKLDVEEALSYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN21</accession>
    <name>A0A084VN21_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006789</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN21"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006789-RA">
        <property type="protein sequence ID" value="ASIC006789-PA"/>
        <property type="gene ID" value="ASIC006789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006789"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006789-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="93" mass="10186" checksum="31D0083CFE89C2A9" modified="2014-10-29" version="1">MIVMDVVVRSTTNNHTLSGSAACQWALRLANKLLGDSSEEEVGRNVCPLLVDICQLAGGGSNEVVAHRAMIVKVSVFHRVSSYQTQSRFSYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNG8</accession>
    <name>A0A084VNG8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="9">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Metallophosphoesterase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ZHAS_00006853</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="9"/>
    <dbReference type="EMBL" id="ATLV01014744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNG8"/>
    <dbReference type="STRING" id="74873.A0A084VNG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006853-RA">
        <property type="protein sequence ID" value="ASIC006853-PA"/>
        <property type="gene ID" value="ASIC006853"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006853"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002510"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008653"/>
    <dbReference type="OMA" id="EHDSPHV"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000081">
        <property type="entry name" value="Metallophosphoesterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="23">
        <location>
            <begin position="50"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="24">
        <location>
            <begin position="337"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00017067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KFB39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006853-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="592" mass="67907" checksum="5871B776F11CB61B" modified="2014-10-29" version="1">MKLKTLLLRLLLSVISLVVFNEFIVYYIVLLKCQWPSKPVSVNGLEPVSVMLLADTHLLGPVRGHWFDKLRREWQMHRAFQSAMTLFQPEAVFILGDVFDEGNWVNQKEFDNYVDRYRKLFHTPRGVALHSIVGNHDIGFHYATRPNLVQRFGDQFNNTGVSLISLRGVNFVAINSIAMEGDGCYLCEKAEKELKTIESIFKCGRGIGQCKDVPKLEEYSRPIVLQHFPMYRESDKECQEHDSPHVDLYRERWEVLSKESTDLIGDLLNPRLAFSGHSHHYCHMLKNRLQIEEYTLPSFSWRNKQNPSFLLTSGASRQFAMRLIILDTAEYVGEWSAKYVMKRINDFKPGPDRFFTLGLPTGSTPLGMYRHLIKFHQQGRISFKYVKTFNMDEYVDLPRDHPESYHYFMWHNFFKHIDIDPENVHILDGNAPDLVAECDAFEAKIKAAGGIELFIGGIGPDGHIAFNEPGSSLASRTRVKTLAQDTLEANARFFGNDISKVPKQALTVGVATVMDAREVMIMIIGTHKAFALYKAIEEGVNHMWTVSAFQQHPHTIMICDEDATLELRVKTVKYFKGLMDVHSKLIEDDVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNJ6</accession>
    <name>A0A084VNJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006884</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006884-RA">
        <property type="protein sequence ID" value="ASIC006884-PA"/>
        <property type="gene ID" value="ASIC006884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006884"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006160"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783846" evidence="2">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="204" mass="21070" checksum="3AD7968032C8D598" modified="2014-10-29" version="1">MNSQAGASRLCAYVFLVILHAFATAVTAQAAIPDDDGVPSSTVSMTPPEPFLLLNETELVDLNQTGPGGTTEAVSSVPTGSSDSSVSMTDSTTTSVSSSSSSSTSTTTITTTSVGTPVENKTMSQEEIQKLLLPPATVEADILHVNISDDNHPHAKANGNTVPPPHAKTPHIISAQMQLANTTEYTNNRATTSGDSVVARKNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPT1</accession>
    <name>A0A084VPT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">AGAP009434-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007362</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPT1"/>
    <dbReference type="STRING" id="74873.A0A084VPT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007362-RA">
        <property type="protein sequence ID" value="ASIC007362-PA"/>
        <property type="gene ID" value="ASIC007362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007362"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022505"/>
    <dbReference type="OMA" id="DKFFFCR"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="81"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007362-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="357" mass="41587" checksum="5B2D820D6F2060E5" modified="2014-10-29" version="1">MGKLGGITTLNRLLSPWLSRTQKTILQASVATGDPSRRQSHHQAHDLVERHDQQHDVEEVRIPIPYGQIAGKWWGPKNIRPVVALHGWQDNAGTFDRLIPLLPKHMSFLALDLPGHGLSSRLPDGMMYHSLDNTLVLFHLMKEYRWKKLSLLGHSMGSILSFIFTATFPDKVDFYIGIDALKPHINDATKFPARLEKRLPKMLQADTRNREKSEPPSYPYEELIERLHLGTNKSVSREAAPFLLYRNTQKSALHPDRYFFTRDSRLKHSLGVGWDQETNLEFAKRVTMPYLFIKAIHSPYYEDRKYFDEFVEVVKKNNPLFELEFIDSMHHLHLTEPEKVAPVVNRFLEKYWKQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQX7</accession>
    <name>A0A084VQX7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007159-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00007850</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQX7"/>
    <dbReference type="STRING" id="74873.A0A084VQX7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007850-RA">
        <property type="protein sequence ID" value="ASIC007850-PA"/>
        <property type="gene ID" value="ASIC007850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007850"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012564"/>
    <dbReference type="OMA" id="TIHHPWM"/>
    <dbReference type="OrthoDB" id="7774077at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF34">
        <property type="entry name" value="PROTEIN LETHAL(2)ESSENTIAL FOR LIFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="71"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB40371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007850-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="207" mass="23670" checksum="4B9171A797F1B76F" modified="2014-10-29" version="1">MSIVPIFFRNWWDDEWDRPLWSSRLLDQHFGGGVSADDLLNAMASVADSHSRRLQQQQSAGRYNRPWHSSCVATKRDSGSTVNVTNDKFQINLDVQQFSPEEISVKYVDKCVVVEGKHEEKQDEHGYISRHFVRRYMLPNGHNENDIVSSLSSDGILTITCPRKEIEKKEERTIPITHTGQPMKKLENGQSAKENGKAKPEGEKMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR05</accession>
    <name>A0A084VR05_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP007174-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00007874</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01015365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525007">
        <property type="protein sequence ID" value="KFB40399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR05"/>
    <dbReference type="STRING" id="74873.A0A084VR05"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007874-RA">
        <property type="protein sequence ID" value="ASIC007874-PA"/>
        <property type="gene ID" value="ASIC007874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007874"/>
    <dbReference type="OMA" id="YHRHSTV"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="13">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB40399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007874-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="763" mass="81533" checksum="4D0470338F6ED8D9" modified="2014-10-29" version="1">MSISNGKTSSDIENVDWNSSGMLTHTRYGSTSSQVSQSSGDICRICHCESDTLNPLLTPCYCSGSLKFVHQTCLQQWLTASETSACELCKFPFIMHTKIKPFNEWRSLDMSGVERRRLCCAVLFHCAAGLCVIWSLCVLIERAAEEVRRGQIGWPFWTKLIVVTVGLTGGVVFIILLIQNAPEKIHPPHASAGSAAVIGSHHMHVRSSFDHPLGGPVGLGGSSSAGGGGNHCELQLNQQGQIIAANIESNSIDRYDRDWTLDDISQVSFKPCLQGSGSLTPMPFHDSLHNVCETNVPVSGAAVVNHRYSTVSNSSNPITLEQQQQQQQQMQQIPSGEQNTSNSSNTSSGSGGPELSLLNKLNNNGAERSGSSSPNVAIATTTITPAGTIGRYVNSAIFLENRDILNDPSVPVGGSVNNAEAVTSGAGSNNKLYHRHSTVLAGGGGGPLPCTFTRIEGNEEESNGQEQPVGSKAFRRYSDTKLLQKQTLSFVQPSEPLALCEIGTHTKDQLLLNPKSIIYDMSNLLGPAVIGPGEQEGGSKDTVSATGDDTLPSTDIQFDAGVDDDGLEMNIQEILDYDQQQQQHFFPNDRKHTGQRLSLENILQASYHDDPSTVPCRPYYDHGGHAPISLGLSSKTPPGGGSTVVAGGRIIPSQHHPPHQPQPATTLSSGAYPHPRSTMAGTIVVSGGVTTDHPLRSPPPAPEMQSYPAHPQLQQQRSHCNESSAATGNRFGGPVEGGTTNNSKHKLFKSLPNLSASSENLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSK2</accession>
    <name>A0A084VSK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525055">
        <property type="protein sequence ID" value="KFB40946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008497-RA">
        <property type="protein sequence ID" value="ASIC008497-PA"/>
        <property type="gene ID" value="ASIC008497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008497"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006251"/>
    <dbReference type="OMA" id="TMMKPKA"/>
    <dbReference type="OrthoDB" id="8068251at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008497-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="95" mass="9926" checksum="E8A5BB851CFFD6CA" modified="2014-10-29" version="1">MRVTSESNSGPPSRTPSIMDSPTLARVERARLRQEADGNHGGPRAGSAASGGGGGGQREDSLERCLLDPKVSAAEGRPTRTTTTTMTMMKPKAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT69</accession>
    <name>A0A084VT69_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008781</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT69"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008781-RA">
        <property type="protein sequence ID" value="ASIC008781-PA"/>
        <property type="gene ID" value="ASIC008781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008781"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014378"/>
    <dbReference type="OMA" id="AINRICY"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB41163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008781-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16909" checksum="B3008305CF5B9953" modified="2014-10-29" version="1">MSITEKDLYRDTPVRYLGYTNEIGEAFRPVIKKVFVHASYAVAITYVLADTADKSKKQYDKPEILGGGLRGAAVASGDTLLWQMFASVIIPGFTINRICWLSKVALKANKVKGPVAKWGPTMLGLLAIPFIIHPIDHAVDYAMDNTYRKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT93</accession>
    <name>A0A084VT93_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00008750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01016281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525074">
        <property type="protein sequence ID" value="KFB41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VT93"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008750-RA">
        <property type="protein sequence ID" value="ASIC008750-PA"/>
        <property type="gene ID" value="ASIC008750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008750"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018036"/>
    <dbReference type="OrthoDB" id="10051571at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16134">
        <property type="entry name" value="RA_RASSF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048945">
        <property type="entry name" value="RASSF8/10_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048944">
        <property type="entry name" value="RASSF8_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21712">
        <property type="entry name" value="RASSF8-10_RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="328" mass="35182" checksum="70AFF68A838F79CB" modified="2014-10-29" version="1">MELKVWVEGIQRIVCGVTEVTTCQDVVFALAHATGKTGRFTLIERWRNNERLLAPHENPLKILMKWGEYSSDVQKRQSKKIHRQLRFYNLPEKLRTPQVARKVATENNHTNTHPQTGPGRRVKSSLDRKVNGLVFSNGLNERVPPVVQASSSSGSGALPVGSVIVGATMKADQHNHHLGTINRYGGVGVGGQQHYHHTQLQNLLCTDNQHHQLDTSSISSISSSSVGGANHSAGSNGSNGSHLLLNGGTTGLGGGGGSGATTNSPITGISSNGALVPPPYRDPPPPRNSPLSHRLLLDGLNTTTVEVVTVDGSHLHHHTXXXXXXXXQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTF8</accession>
    <name>A0A084VTF8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008842</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTF8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008842-RA">
        <property type="protein sequence ID" value="ASIC008842-PA"/>
        <property type="gene ID" value="ASIC008842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008842"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="17381" checksum="5492737ECA173F55" modified="2014-10-29" version="1">MAPRALREPTRAHSVTAPAGVALTTVLADLKFGVRGNEYVHSIAHILCSSGLLTSYVRLRSPPAESAAANCPPGGCEFVVTIDSRFAGSTETGTTPPGSSPLLPGGHYNGKGIESGVVGFRVDDQIAIVIIVGFVFGWLVQWRIPQITPRPRSLCSVQFGQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTM6</accession>
    <name>A0A084VTM6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00008916</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTM6"/>
    <dbReference type="STRING" id="74873.A0A084VTM6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008916-RA">
        <property type="protein sequence ID" value="ASIC008916-PA"/>
        <property type="gene ID" value="ASIC008916"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008916"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008047"/>
    <dbReference type="OMA" id="WSIMPLN"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002651">
        <property type="entry name" value="ER membrane protein complex subunit 1-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="13">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="700"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB41320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008916-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="906" mass="99705" checksum="84CE78B9C910BA83" modified="2014-10-29" version="1">MALLLTSWFSDCFRRQQYVGKIIHGAFDITSVDRIIVTTESNVLAAISAKTGELLWRQVLENGPRGTVKLLHVTNPSSTGARVGRGAASLGYDVVTVTGSNPALVRGWNSNTGTLGWEWSLLPALPEEAALSAVWFEHDGLLYHVVPVWGSHLEVTPYQTTSGQQARSTTSRIAAGWIAKDRCSLTGTFFVCAIKEQLLALDLVGDATSMVISKPLGSEAVGCPKPVRGGEPAVIQNGRYYSLRTDQKLAFGPRDSALIDRTVQEGEPILLQGTVDRANNRLTVNAHRLRDFVRFDPVEFSTEYSESLGDPELVAIRCKQQQQQSSTTKPGLACRVLLSAADGAIVLVQQGKIKWVREEALAEVETADFLDLTLSDAEGAIEEELNNKNGDVFGAFQRRISSQVVHMKNLFLHILGIGPVPSTAQSAGLVRDDFGLHKMLIVVTASGKVFGIDNVSGKHHWVRYLPSFTGFGNGQPMRLLVQRTSRFYPLSAQCVILGRERTEPRRGLLYIFNPITGQPVAGGGLVELPYRVQQVALLHQTGPDFLKGLLLLDYNDQAHVLPESLAVYADNFYLFTTNPETAQMRGLLVKHRPGATSDGNQLETIPTWQIDLSGAGKSQKIIACEGKSAIEHVHSQGRVMADRSVLYKYINPNLVAVATYGPDNIHKSILNVHLVDVVSGSIVFSMSHKRIRPPLHMVHSENWLVYSYYNDKARRTEMTSIELYEGKTQTNGTVWSSLDAPPLPMVERQSYILPMAVASLKETITEKGITSKHILIGLTTGAVAEMTWALLDPRRPVTSPEKAREEGILPYMPELPLPHEILVNYNQTVANIRGIHTAPSGLESTCLVLVHGLDLFVTRVSPSKTFDLLKEDFDYFLITVVLIVLTTTSCVVKQLASKKIIKQAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTN7</accession>
    <name>A0A084VTN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008814</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525079">
        <property type="protein sequence ID" value="KFB41331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008814-RA">
        <property type="protein sequence ID" value="ASIC008814-PA"/>
        <property type="gene ID" value="ASIC008814"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008814"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008814-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="7282" checksum="AF9A37290E85DEB4" modified="2014-10-29" version="1">MPQKYGCSTVSPARTRVVIAACSWQFNRGRPGRFAAKEARNLQASRDPCAVGIGENRFWVRPPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VTY8</accession>
    <name>A0A084VTY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Penicillin-binding protein 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009017</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016563">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525093">
        <property type="protein sequence ID" value="KFB41432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VTY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009017-RA">
        <property type="protein sequence ID" value="ASIC009017-PA"/>
        <property type="gene ID" value="ASIC009017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009017"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009017-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="65" mass="6782" checksum="606D4AE3C3690A8A" modified="2014-10-29" version="1">MSFLGATCLFGWQNSCPPPTSVNVPATDGIYPLCSSMSFPFGCENYPKQSSGSASRGPQPCCDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUM7</accession>
    <name>A0A084VUM7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00009297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="ATLV01016973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525139">
        <property type="protein sequence ID" value="KFB41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VUM7"/>
    <dbReference type="STRING" id="74873.A0A084VUM7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009297-RA">
        <property type="protein sequence ID" value="ASIC009297-PA"/>
        <property type="gene ID" value="ASIC009297"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009297"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010925"/>
    <dbReference type="OMA" id="FNVMKPD"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000013">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF25">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009297-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="282" mass="30361" checksum="CB723C1B11419212" modified="2014-10-29" version="1">MSNDGEIQEAFELAVTLVKQCNEIVLEGYRTASKRVDVKGKHWDLVTEYDQRVEDVLIAGLRARFPHHKFCAEESAAASGEKLALGSEPTWIIDPIDGTVNFVRGIQFTCISVALAVDGQLVIGIISNPSNNELYTAIKGQGAFLNGAPIKARTTELLKDALVGHEFSIGSYQPIRAALFERGKRFIEECLGLRAFGSAALSLAYIASGQIDAYSIQFLKPWDIAAGALLITEAGGTVTSITGGSYDIMKPDIIAACSDALAARLLKIIGEVDLDLAQQKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV76</accession>
    <name>A0A084VV76_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP000380-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009715</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV76"/>
    <dbReference type="STRING" id="74873.A0A084VV76"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009715-RA">
        <property type="protein sequence ID" value="ASIC009715-PA"/>
        <property type="gene ID" value="ASIC009715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009715"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021493"/>
    <dbReference type="OMA" id="WDYTDAV"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="709" mass="79171" checksum="AB43F98F374174B0" modified="2014-10-29" version="1">MPDISQDEFEAKLPHLAPATAAELRKRANSGGSRMLGRNTSNAPATNQPADESVSGPALAEPVYGYKREISHRIFVNRSMHLENIKFYGFDMDYTIAEYKSPQYEQLGFDLVKERLVSLGYPAEIRQFEYDPSFPVRGLWFDSLYGNLLKVDAYGNILVCVHGFEFLKHHQVYELYPNKFLQLDESRVYVLNTLFNLPETYLFACLVDFFTHSPQYAEQVDRTGVKYGELFMSFKSIFQDVRGAVDWVHIYGDLKKKTLENLDEYVKKDERLPMVLSRIRESGAKLFLLTNSDYNFTDRIMTFLFDFPHGAKPDEPHRDWKTYFDTIVVDARKPLFFGEGTILRQVDTTTGALKVGTHMGPLQANQIYSGGSCDVFTKLIGAKGKDVLYIGDHIFGDILKSKKIRGWRTFLIVPELVQELHVWTDKCQLFAELQQLDVRLGDLYKNLDSSAKEKPDIRSVRTAIRDVTHKMDLAYGMMGSLFRSGSRQTFFSSQVVRYADLYAATILNLMYYPFSYMFRAPAMLLPHESTVAHEQRFTLDAPMIQRSRPPRAIGGGSSNPLASSSTSALPPTVASSVSMFSKSALEGAASAAAAMLVSLTTAKTMADASAMLATQELADELGDLAGGDESKELTRLLLQEKDGLLAVSVPHTRPETPRSVTHTHDEDYSDEDSDDQKKVVSAAGATAAGCEGVQSSSATDDGPDPPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVS9</accession>
    <name>A0A084VVS9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP013203-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009736</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525158">
        <property type="protein sequence ID" value="KFB42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVS9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009736-RA">
        <property type="protein sequence ID" value="ASIC009736-PA"/>
        <property type="gene ID" value="ASIC009736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009736"/>
    <dbReference type="OMA" id="WTHREEA"/>
    <dbReference type="OrthoDB" id="7735283at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF0">
        <property type="entry name" value="DAEDALUS ON 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="350" mass="40354" checksum="BA8A50479241391B" modified="2014-10-29" version="1">MPADMNLVPTVMPFGKFNTNIRMYNKRNQTMLAIRPFWMKRFECMEQPYRYTKILSCQMESHRGVPQMVHVVANVTQLLSKVFISTELYAKHKQSQTFIYGTSFEYCEFMTAKDSKLNPVAVALYNYAKHNFPQVLKECPIMGIFNVSNLLLDRNLIPPLVTPGLYICSQRFYTKRNETVLHYIAEFSVGAPSIFNKMSQLIHCRVWTHREEAQIVDVLLDIREPISKLTIAYKIYTQYFHTRNLLYGTEFEYCDFVKSSDVSFNPVAQIALNLAKDNFPEIVKPCPVQGLINVTSLRVVQKLLPPYAPPGAYYFDIRASNKRNQTIIACASEFTVVQKSLINQTLSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVU7</accession>
    <name>A0A084VVU7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">NusA antitermination factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009750</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVU7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009750-RA">
        <property type="protein sequence ID" value="ASIC009750-PA"/>
        <property type="gene ID" value="ASIC009750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009750"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="89" mass="9915" checksum="B90354D6D9FBB53D" modified="2014-10-29" version="1">MMHKGPRWMSMWLVRPFQCRYVGKCFVHRYGFPGTAGLADTMQKNPIVDRIGACGKPSAQTLNAIASFGLEVLSPNGHEFIAPMFRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VW66</accession>
    <name>A0A084VW66_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009884</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01017495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525170">
        <property type="protein sequence ID" value="KFB42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VW66"/>
    <dbReference type="STRING" id="74873.A0A084VW66"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009884-RA">
        <property type="protein sequence ID" value="ASIC009884-PA"/>
        <property type="gene ID" value="ASIC009884"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009884"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006515"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009884-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="470" mass="53900" checksum="358184C063440CDE" modified="2014-10-29" version="1">MIGAKTAALFLTHRTPHLLIVRLRHYFKNMLCTDLHPPAAVRGMTRLSREAFNKTIKTPHLIVPKDVNLNNVCRVIKKFLLKMERYKPVVSEEYKITLHPLAVQRWEDLAEVELDKLGIDSKALVWQEIQLGYENWKYDEIFKAVLPEDKEALSSFSKIGHIVHLNLKDHLLAYRELIGAVLLDKIPGCRTVVNKSVTIDNTYRNFQMELLCGEPDYQVDVKENGCAFKFDFSKVYWNPRLSTEHEKVVKMLNKNDILFDLYAGVGPFTVPAARKGCTVFSNDLNPDSYQALVENCTLNKVSKNVKCYNKDAIDFIQQEMKHALLETCANESFKGHIHITMNLPAMAVEHLPYFPALLKGEKIVNLQQKPLVHVYCFAKGVDDKKLIAQKLVEQWLGTDVDDKLKEIAFVRNVAPNKDMMRVSFYLTEDLLYGHSDAGRKRHLDTEDKPAEESKRPCQISDVLEDGKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWF1</accession>
    <name>A0A084VWF1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009979</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01017583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWF1"/>
    <dbReference type="STRING" id="74873.A0A084VWF1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009979-RA">
        <property type="protein sequence ID" value="ASIC009979-PA"/>
        <property type="gene ID" value="ASIC009979"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009979"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012738"/>
    <dbReference type="OMA" id="WHFEADE"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="133"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009979-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="338" mass="37181" checksum="7EB5309D0A6C7809" modified="2014-10-29" version="1">MAPLRWGIASSGKISHDFTTAVGTLPSDEHQIVAVAARKLADAQKFATLHGIETAHEGYEALAKNPNVDAVYIGAVNNAHYEIGLLMLDHGKHLLCEKPLCLNEGQSKRLLQRAADRKLFLMEAIWSRFFPHYRLLRERIGRGELGEVREVDVEFGFVLADIDRLRLKSLGGGTVLDLGVYTIQVCLWAFGGKAPTKIVASGVTNEEGVDLEVTAELHFPGGGIARMKTSALKQLNNEAVVKGSKASITLHDFWCPLKLTDTDGTVRTDALPPARYPFNFQNSCGLRYEAEEVRQCIRAGRLQSESVSHADSLLIAHIQDEIRKQVGVVFPEDAQFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXH2</accession>
    <name>A0A084VXH2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010399</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018071">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXH2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010399-RA">
        <property type="protein sequence ID" value="ASIC010399-PA"/>
        <property type="gene ID" value="ASIC010399"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010399"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010399-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="87" mass="10234" checksum="16AF00DD4136AB2C" modified="2014-10-29" version="1">MAHTRPPPAPQRSRVRKLFGVWEQPPGSKRRTRASTRDGSVTVHIWWIWFWGERRGWDIDRMDAGRYELHTPNTPTTDTDTPSQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY60</accession>
    <name>A0A084VY60_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010778</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018322">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY60"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010778-RA">
        <property type="protein sequence ID" value="ASIC010778-PA"/>
        <property type="gene ID" value="ASIC010778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010778"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010778-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10931" checksum="C5701C7A304F7967" modified="2014-10-29" version="1">MSTVPATGNILRFVFAVCLMAIVPQIGTQWTTTAKCDAEQRQTAKESLRFAGDVSKSFPKQPTVVADGGRFGLHSKRPISRILSLRNDTDDDDDMLKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYN4</accession>
    <name>A0A084VYN4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP008881-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00010759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYN4"/>
    <dbReference type="STRING" id="74873.A0A084VYN4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010759-RA">
        <property type="protein sequence ID" value="ASIC010759-PA"/>
        <property type="gene ID" value="ASIC010759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010759"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023248"/>
    <dbReference type="OMA" id="RMYFILW"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000016">
        <property type="entry name" value="ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF71">
        <property type="entry name" value="FI05338P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010759-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="387" mass="44853" checksum="B059E3101FF93523" modified="2014-10-29" version="1">MGDDGYLTKEHLAGFDNYKYNAKDTSPLSIYIMHPFWNWLVEYFPKWIAPNLMTFAGFLFTVANFVMLSWYDWGFWASTELEDTTPVPNWFWALAAVNIFLAYTLDGIDGKQARRIKLSGPLGELFDHGLDSYSAFFIPACLYSIFGRGPTSVPPIRMYYIMWTIFFNFYLSHWEKYNTGVLYLPWGYDLGMWGSVLMYLATWKFGYQLWKVALPWGISAGQLMELSLHVSAMSNLPVVVYNMYRSYKDRTGKMRTMKEAMRPLFTYGSFMFVCLLWVFVSPSDIINRDPRAVYIMTGTIFSNISCRLIVSQMSNTIAETFNWLTGVLCCAIVLSLTMPLLERPLLYMLVIGSSLAHWHYGTGVVQQMCKHFNRRCFLVTKRSESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYU4</accession>
    <name>A0A084VYU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010909</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525234">
        <property type="protein sequence ID" value="KFB43138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010909-RA">
        <property type="protein sequence ID" value="ASIC010909-PA"/>
        <property type="gene ID" value="ASIC010909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010909"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010909-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="139" mass="15595" checksum="6A12AE94C08D38CE" modified="2014-10-29" version="1">MLTDPTVCPSRETNGGNGAGARCIYPFNQNVPRPVEPDAESTRGVHGPDGQPVVVFFFFCIASLPKRRKWSEICFKCCPHGGFSLTRTTGKPAGRLRSPWRIDLMERFRWLHSSDISNGKRKGRLGLVYELSSTRRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYV4</accession>
    <name>A0A084VYV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010920</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018490">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525234">
        <property type="protein sequence ID" value="KFB43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010920-RA">
        <property type="protein sequence ID" value="ASIC010920-PA"/>
        <property type="gene ID" value="ASIC010920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010920"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005215"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="12525" checksum="87403D63CAD1F35D" modified="2014-10-29" version="1">MAKTANPDVHKAAIPVLPGELMFQKRIMTAYVRRDGPFRSGSTVQEVLGAQAYQLAVKDDSASPSASSPLGITVLHVAGTITMMMTTMATMVSVKTFAKTIVLLPANCTSARWPVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ26</accession>
    <name>A0A084VZ26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010996</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010996-RA">
        <property type="protein sequence ID" value="ASIC010996-PA"/>
        <property type="gene ID" value="ASIC010996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010996"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009746"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010996-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="133" mass="15504" checksum="09AB5C237A832081" modified="2014-10-29" version="1">MPMPAHLLLLMLLHWHTVLLLGWGWYCQVRLLRRAQKISYMPQQTGLLRPLHLTGRPRSNRFDEPVRTIVVHSWCIPFRVSITCMGVPPFVNVCMGKEPPPSKPLQIKLARTFHTHANVDAYRDAPFRELMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZM9</accession>
    <name>A0A084VZM9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011235</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525252">
        <property type="protein sequence ID" value="KFB43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZM9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011235-RA">
        <property type="protein sequence ID" value="ASIC011235-PA"/>
        <property type="gene ID" value="ASIC011235"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011235"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011235-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15626" checksum="D8A5D0193AE61B6A" modified="2014-10-29" version="1">MANLAGLHRRRGRSECRLVELDCSRAAMGHVRSYKVRERRVHSHLTGATHHSATRAVWAGSTSQTNIPRKKYPPFGTEPLQSSQVGNFRMLGPATKECPMTHAKYGEGIAQKPSYLLANHNILSTHTYSIQTMNNGGDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0E2</accession>
    <name>A0A084W0E2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011416</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011416-RA">
        <property type="protein sequence ID" value="ASIC011416-PA"/>
        <property type="gene ID" value="ASIC011416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011416"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011416-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16010" checksum="1F34CB37AB22A5E5" modified="2014-10-29" version="1">MSGRGEGEGENCIRFASPPPQLFQPEPYACLQLCMRKSTASHTYFFGGLEDIPDDDAGDLLVQLFHLDAQDTTTGCAWDGTAKANGEFVLPEGVPSREKTTCCPSSVLPFSGCILIFLLLFSSSFTKGAKGNISQPTMEWQKAITSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0L9</accession>
    <name>A0A084W0L9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0L9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011501-RA">
        <property type="protein sequence ID" value="ASIC011501-PA"/>
        <property type="gene ID" value="ASIC011501"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011501"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007051"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011501-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="13704" checksum="2ADC76E1AAA1AA56" modified="2014-10-29" version="1">MELRQTMQRSLPAPTSPYQRQSSAAGCSNLPAGSELLLSHTLSTSGVRVRRKHLPNLPTICEKLRAIFNVQLQEIQSKEEPQYQQQFATFQVLQETIAGPGAAVGSTVGSIVIGNGDLLCQIQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W1E8</accession>
    <name>A0A084W1E8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011872</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525267">
        <property type="protein sequence ID" value="KFB44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W1E8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011872-RA">
        <property type="protein sequence ID" value="ASIC011872-PA"/>
        <property type="gene ID" value="ASIC011872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011872"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011872-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="199" mass="21885" checksum="EAB493CDD211BC49" modified="2014-10-29" version="1">MHRNSTVAGRPFEAFDDKGSEQDRLRPRSGSQDLGIGGRTNKPTPRSAPIAIQHCARRSSSSSSSSTTPAPHRHHSSSASIASRPRAYVTSIRKCGHTPRRSRTNPVGWQFRNQGRVSPGRHGRAFYKSPIEMKSSKQYGLIGVPERSARCRPFPYRAAGKSAVHSFVDSFSFSVPVAVFAAKRPILFGRPVLPSMVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4C0</accession>
    <name>A0A084W4C0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Lytic murein transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012892</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4C0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012892-RA">
        <property type="protein sequence ID" value="ASIC012892-PA"/>
        <property type="gene ID" value="ASIC012892"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012892"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012892-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="7184" checksum="EC7EFB9433B03819" modified="2014-10-29" version="1">MPKDSATSSNINQFGVEELEETPTYDTLTSTSSSLDTTMVLMRSRCCWADFPLLPQRIQLQKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4W5</accession>
    <name>A0A084W4W5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Intraflagellar transport protein 74-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013204</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525300">
        <property type="protein sequence ID" value="KFB45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4W5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013204-RA">
        <property type="protein sequence ID" value="ASIC013204-PA"/>
        <property type="gene ID" value="ASIC013204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013204"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="121" mass="12932" checksum="E1F479C1D0353B83" modified="2014-10-29" version="1">MRAAGKTGKQYTRPVPSRILCTMNFAQLMSTGALRPASCAHLHLCATANEVLLLPSERVPLPKVSSASSFGGGAYLGPVERGVRVFFDVGPVQCRHGVAGIRPCRGLVRQLPMSRRAMDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5I2</accession>
    <name>A0A084W5I2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00013475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="ATLV01020648">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01020649">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W5I2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013475-RA">
        <property type="protein sequence ID" value="ASIC013475-PA"/>
        <property type="gene ID" value="ASIC013475"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013475"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019582"/>
    <dbReference type="OMA" id="HWPFLRD"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
        <property type="entry name" value="Beta-alanine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="73"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013475-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="389" mass="44067" checksum="E696C88A2C5C22CE" modified="2014-10-29" version="1">MADGNFKSLDETLNKYIPPEELREVKRVLYGRSDDNQLKFTEETITLAKEVDVELKGYFFTARKEDLRRPRIVRVAAIQNTVDIPTTAPIHVQRDALHEKIANILRVAVTAGVNVVCLQEAWTMPFAFCTREKFPWCEFAEDVENGPTTKMLKELAKQYNMVIVSPILERDANHHDTIWNTAVVISNNGTVIGKHRKNHIPRVGDFNESTYYFEGDTGHPVFETQFGRIAINICYGRHHPQNWMMFGLNGAEIVFNPSATVGGLSEPLWGIEARNAAIANSYFTVAINRVGTEVFPNEFTSGNGMPAHKDFGPFYGSSYVAAPDGSRTPGLSREKDGLLVVEMDLNLCRQIKDFWGFQMTQXXXXXXXSQTISHKLSKKINQFLNYYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5R3</accession>
    <name>A0A084W5R3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020688">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5R3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013601-RA">
        <property type="protein sequence ID" value="ASIC013601-PA"/>
        <property type="gene ID" value="ASIC013601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013601"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="10491" checksum="DAD9540BAADBA650" modified="2014-10-29" version="1">MWAKRNKASSPAVSCPGPNDALHWRSLVLITERTPPGGQPGAANGIGSENAGNIHHGPHALHELRMEVGMCQGKVHLISARSGFSREIVCRCGGSQVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W601</accession>
    <name>A0A084W601_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013639</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020710">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W601"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013639-RA">
        <property type="protein sequence ID" value="ASIC013639-PA"/>
        <property type="gene ID" value="ASIC013639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013639"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013639-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="7206" checksum="D01DE713A24CBA6B" modified="2014-10-29" version="1">MHRPDIDGIAPFEVSEWKTLKQSEEEEKGFGRKETVTGFRCNCTSVRHGSRRDVPQLSEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W620</accession>
    <name>A0A084W620_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">ASPIC/UnbV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020719">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W620"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013522-RA">
        <property type="protein sequence ID" value="ASIC013522-PA"/>
        <property type="gene ID" value="ASIC013522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013522"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013854"/>
    <dbReference type="OrthoDB" id="7738031at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013522-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="222" mass="25344" checksum="244311A4D743ACC7" modified="2014-10-29" version="1">MPQHSSDCNFFNEILRRQRRIRRTDRQQIARRILANGPEVHIKNEAYKLLPARNKRFHKAVDIFIASRRSQAVKRQGGRVDDPRAGRTTIHSSRMASTFANLPRAAQLMYLNCADFVGSSTKATVCSDPFLLFLCDFDKECAEADERSRREDGTTGGAFEDVPSEDEANHQLPLQYERRPSQDQVLEAARQTWNALSDEAREPYRFRAITAALFPAAIDQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W661</accession>
    <name>A0A084W661_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525306">
        <property type="protein sequence ID" value="KFB45705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W661"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013653-RA">
        <property type="protein sequence ID" value="ASIC013653-PA"/>
        <property type="gene ID" value="ASIC013653"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013653"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013653-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="003172D5E0DA775E" modified="2014-10-29" version="1">MSRLKYGIGSYRSISAVSCSSTRDCAAGRKAGMARIRHPDVLDSRTPNRNTNRPTERPVRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Z5</accession>
    <name>A0A084W6Z5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein O-mannosyl-transferase 2</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein twisted</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ZHAS_00013955</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with Rt/POMT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="ATLV01021070">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Z5"/>
    <dbReference type="STRING" id="74873.A0A084W6Z5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013955-RA">
        <property type="protein sequence ID" value="ASIC013955-PA"/>
        <property type="gene ID" value="ASIC013955"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013955"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003348"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="5561486at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23282">
        <property type="entry name" value="beta-trefoil_MIR_POMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000026">
        <property type="entry name" value="Blast:Protein O-mannosyl-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="386"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="447"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KFB45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013955-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="725" mass="81618" checksum="15BF240BFDA591A8" modified="2014-10-29" version="1">MAAATASESDASPKNATVNKSMAQKKKAGASESSDKSEQKTWWWLLFGVFLALTIGTRFYNVTVPDHVCWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYDGTFPFDKPGDKYNGTHYEGMRIFCTALGAAIVPMTFHTVWDMTSSLTASTFAAAYILFDIGMLILNRYILLDPPLIFFMTASVMGMARVSRLTQLSASFTTGWWLWLAFTGAMLACTISVKFVGLFVVLLVGLHTASDLWDVLGDLTRPISYTVRQLAARALTLIVLPILLYAAFFYVHLAVLNRSGSGDGFYSSGFQSNLVGNSLYNVSMPREVAYGAVVTLKNHKTGGGYLHSHNHLYPKGFGARQQQVTTYSHKDDNNRWLIKPYDKPVPDNITLLRHGDLVRLEHVATRRNLHSHREQAPITKKHLQVTCYGEEGQGDTNDVWVVQIAGGKAGQAAETVTSRLTFYHYIERCVLTTTSKQLPKWGFEQQEVTCNPNIRDKAAQWNVEDNQFDKLPSVNFQVYAPGFISRFLESHAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFFSGSDHRVYLLGNPIIWWSNLVFLALFLIIFGVEIIRYQRGSAENTTTRSSAVDENKWRLLRAGLWLFGGWLIHYLPFYAMGRVLYFHHYFPALVFNSMLAGVMLDYVTVRLPAWMRHAVLGVAMAGLVYSFVLFSPLAYGMSGPFSHEPNSTLAGLKWMSSWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7D6</accession>
    <name>A0A084W7D6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014146</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7D6"/>
    <dbReference type="STRING" id="74873.A0A084W7D6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014146-RA">
        <property type="protein sequence ID" value="ASIC014146-PA"/>
        <property type="gene ID" value="ASIC014146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014146"/>
    <dbReference type="OMA" id="DYRTIML"/>
    <dbReference type="OrthoDB" id="549243at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014146-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="253" mass="29393" checksum="A6B1741873025135" modified="2014-10-29" version="1">MELLDLDDYSLTKIFSYCSIEDLLKLSDISGRFRKLCQPRTGLLISPCMRKFELDYRTIMLSKEDRHVESIFRMFGSSMESFRFSAGIGRIVDERLRTCVVYYLNWYCKSLRHLTINFVPLPKWYLTILAGPLHTLVSLDLAYCDLADDSLGEILPSRTLQLRTLAIPGNQYLTGAFLANWTDCPKLELLDLRYCPALKNDMIDQFLQEHFKKHSKRVIVVVDSGRIWSPRNKDIVPKEDRSIALRTESPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W839</accession>
    <name>A0A084W839_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00014378</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W839"/>
    <dbReference type="STRING" id="74873.A0A084W839"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014378-RA">
        <property type="protein sequence ID" value="ASIC014378-PA"/>
        <property type="gene ID" value="ASIC014378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014378"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019000"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="10">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="9">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014378-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="703" mass="80098" checksum="B5C4B56E1C75F4FF" modified="2014-10-29" version="1">MLVTDINNVKIYNLSGGKSVPEWLSNKKQKNATKKHADNDRRIELIQDFDMPGVASCIAVSPDGQYILATGTYKPRVKCFEVCNLSQKFERCFDSEVEKFTILSDDYSKVVFLHADRYVEIHAAHGRHYRLRVPCFGRDLVYHKPSCDLLLVGASPDIYRLNLERGQFLLPYTNTSASAIDSITVNPEHQLICAGTQEGTLEAWDHRDRNCVGTLDVATSLQHTKEIASVTALEFKNGLTIAAGTSTGHVLLYDIRARNPLAVKDHLNQLPIKKIRFQPGLKSVYSLDSAMLKIWDETSLKQKACIEAVSNFNDFAHYPGSGLFLFAQEDTKMLPYYVPIEGPAPKWCSFLDNLVEEMDSEAVQNVYDDYKFITKQELAELKLDHLEGTRMLRAYMHGFFIDIRLYNKAKSVSETFVFDGFRKEKIRKQIEAARPARIQLKTALPEVNKELAQQLMEEEHMSNPKRSAIAKGVLSDDRFKTMFENPDFEIDKEANEYRILSMVLKRVERDKARQKENVVFEGPGDDEKDQQSTDDDLYSEKSESESEDEKQESDEGIDNEEPPVSSKNGGSKKPKVPTASFVRKPSAPPKQQDDESHGEFSLSVEEGANFNIMQPSRQIQSVSLGKRVNKLEHDTTSVQFDKGIGRREITFTLPDRSKGRKTDQEQNRSRQQMLKKHKEERRQVIRSAKGVIKKMVMKKPYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9A2</accession>
    <name>A0A084W9A2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NHR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01021661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525321">
        <property type="protein sequence ID" value="KFB46796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W9A2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014801-RA">
        <property type="protein sequence ID" value="ASIC014801-PA"/>
        <property type="gene ID" value="ASIC014801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014801"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006998"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007584"/>
    <dbReference type="OMA" id="QHTTQMA"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="248"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="478"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="669"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="879"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1785"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014801-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1850" mass="199418" checksum="AF10E7E3ED2ED150" modified="2014-10-29" version="1">MSSGSVFHRRCGKRITLTNGNRTARRNVSEFNHGLVLSAEPIQDDVLFEVRIDEKIQAWSGSIEIGVTTVNPESTELPPCATKLRNSTWVMSGISVLKDGMLLVESYGLDLEKLGEGDRVGVQRTARGELVFYVNGDPQGVAARDIPRQVYALVNLYGKCAQVSISSGQPSELAAAGVAEGYGAPADTSTVTTMPPISENIDLPMSVEISVSGSTTGTTTTSMAGATSTSGIIGTGLEETGGPDAGDKLRFHTRCGSLVKLSANCRTAERRRPLDEFNNGVVMTHRPLWDNELFEIRIDRLVDKWSGSIEVGVTTHCPSALQFPATMTNLRSGTIMMSGCGILTNGKGTRREYGEFNLDELREGDRVGMMRKSNGNLHYYINGRDQGVAATRVAQTLWGVIDLYGMTIKVTIVDRDEREQRNLVTRRNHLLSMPTTTTTTTQQPMAELPLALHGPTAMVGSPPEGLVDCSPSSGMHDRLLFHPICGSHASVTHSGRTALRPNASDDFNNGVVLTRRTLRPNELFQVRLERVVTKWAGSIEMGVTTHSPTELDFPFTMTNVRSGTWMMTGNGVMHNGMTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAGTNVPEKVYGVIDLYGQAAQASIVDTSECGTPDTGNSTISNTTLFPSVEPRMRFNTAVHGRNAHILSNGLTACRPKALAEFNDAIVFSSRPLRQRELFEIVLETVVDRWNGSIEIGVTAMRPDELSLPSTATDLEHDTIMVSGTTLLLNGFTVRNDLPFDLDSLGQDSRVGVMRNGDAIHFFINGTDLGSFYESKAPNLYAVVDLYGQCAQVTITSPIAHGTGGVGPAIPGDLRAPYAISENSQSLQATSVIQPMALVESKHRWSCISGNSVTLMHNWTLATRCSNSALSHCLVFSDRPLVVGETFEIKITEVNPLYAGCLRVGATDLNLSDEHVRKNIPISMRRIPANVWYVSGNEVRHNSTLLQKSLASLEWLRAGDRIAIELTPSRTLRILLNSEDMNINFAGLPDPGDVFAVVELIGSTMAVQVISSQGPSSPLRPCSLRLQDSLELGLDPLNKQDSMLESIDSDSLSMEFSELYIGKNVTLGDERKSAARVQSYNQAVVCLSKPLCKGHSVSVRVNTVNPLWKGTIAIGALGMAPGVASAQFPFPTSAILFRRPCWIATHDYVNINGTKTQSRYGEILDSIQPGTIITLTLTHAGSLVITCGQTQLDELATGLPHHVYPVFDLYGKCERVTIYNGDPKNGSPIDEELAALPNEQQQRVMNVGGSLTGGPDSNTLVQATNSTVSTGADGGENVPQCEKADLEVHEKETDQTTVATSQPIAGGSAGGGSSNAMSRSVMDCVSENLLMNISIKIRTANEARNHELSNSCCLRDSLQLQHSTNLNIQRSQSTHRFNGANSNMQGSLDSNRGGTSATGVNGVGGEQSQSMSSGNFDEGFEDYQHRPATVAAGSSGAIEPSTTDRGENTDTNYLDDGESSIDFNIQINNEDEDRDRNTLANNRAKLGLPLQPVVGGVITGGSVESGPTTALCSLPPIAIGMQRLAPEGAEDEAEGAFTQHQRMNVRSGSISLPPTLPPPPENRDCDNLKLVISFKRTLMLPDAFFVDEPCACYCAGCHRPGLANPVLKGWVRFRLNQQTVQGGNGGTVNTTDDFVWTTAYYNTRVDKIRSVLDHGQPLPIETGYQLPESSISATSSVSDNFIPGTHILLRSFPDATEPIHSSAGVPLSTARGRPFPLRYMVNGQFFHIRTAFEVRVRSQSLSAVDHLGEQRNAQVDGGGGVSSGNTTGHSITATSGSSSSGSIAPQDNTLRSWTTKEADACVLTALLLHLVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB23</accession>
    <name>A0A084WB23_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015666</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WB23"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015666-RA">
        <property type="protein sequence ID" value="ASIC015666-PA"/>
        <property type="gene ID" value="ASIC015666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015666"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015666-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="62" mass="6961" checksum="5FDEFB3D94F050D9" modified="2014-10-29" version="1">MGLMRFDDQTMHALRQRTTHPITFFGPSSDRCGATERHGVASTDNTTSASLPECFSFRFFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBL9</accession>
    <name>A0A084WBL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00015585</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022369">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015585-RA">
        <property type="protein sequence ID" value="ASIC015585-PA"/>
        <property type="gene ID" value="ASIC015585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015585"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5662" checksum="443D151DA58516DB" modified="2014-10-29" version="1">MRYPSVPLGSIGFPNGRTAFNGQRSSSLPAVSVLFAPPKDDDTLERAPIAPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDL7</accession>
    <name>A0A084WDL7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016291</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016291-RA">
        <property type="protein sequence ID" value="ASIC016291-PA"/>
        <property type="gene ID" value="ASIC016291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016291"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016291-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16402" checksum="11B25DADCF26C6C7" modified="2014-10-29" version="1">MARHSSIHGGGWEVYAMFLTLPEKKVRTVGDGISAPRESAVVDALRQPIPSISNEQTGDVIHRKPAEPRQPEPTAAHPVGSSATGTTQQHRIRWDCTKTTSKSDKMLAISCSVCRPARAVRRRFRCSFLRERSSTTVSGAFPFIPYLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDV9</accession>
    <name>A0A084WDV9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004997-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00016527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDV9"/>
    <dbReference type="STRING" id="74873.A0A084WDV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016527-RA">
        <property type="protein sequence ID" value="ASIC016527-PA"/>
        <property type="gene ID" value="ASIC016527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016527"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015371"/>
    <dbReference type="OMA" id="WYKSCGD"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
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        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
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    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
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            <begin position="276"/>
            <end position="489"/>
        </location>
    </feature>
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            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB48403.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016527-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="493" mass="54330" checksum="468A14D0471CB2E9" modified="2014-10-29" version="1">MRTFFLVLTLALALASAASTSETKETDVKIPEEVAEEIAASDDVKASDDTVRDYQYYNVVHGSQSEGGRPPNFAPAKIGYGGGGYDGEYEGSEGYEGGYEGGNAGGYGGGYGGGNAGGYGGGSSGGYGGGSSGGYGGGYGGGASYPTRPPKPDTGFDFPKPKPPPKCNCKDIIDQIDELDEKIVKSLLDLEIKADSIQGDVATIHKETEKVAFTTSQTQLIANAVDNQLNIVRQNLTIIESDVDELTQFQQNVPDRTYLIEALFGLKCSYERKTKRGDDRIYSSCDDPSIKKTGSYWIKANFFKPVKAICLLDYGGRWMVIQNRFDGSVDFYRPWREYKFGFGNNEGGEYWLGLDRIHQITTSGSYELLIVLEDFEKNITYAKYEQFAIGGENEQYKILKLKSFIGSAGDSFMAEGMRFSTYDFDNDRFDQNCAAVTHGAWWYKSCGDANLNGLYLNGPTLEKTGIFWNTFRGYNYSLKKTRMMIRRREGSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE39</accession>
    <name>A0A084WE39_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00016469</name>
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    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB48483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016469-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="12789" checksum="3DA5244A062A135A" modified="2014-10-29" version="1">MPSYAGCTSREAAVFPRDCPAAKIDQRREVSMTQAGKIVHMPQLPVHTNTHTYTHSRRGDLGKMGNQSPCWAVTMVLVPTGTELKTGTRTRRSINCSSLEGATKGSGGWKRGSDEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEU3</accession>
    <name>A0A084WEU3_ANOSI</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">ZHAS_00016741</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="74873.A0A084WEU3"/>
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        <property type="protein sequence ID" value="ASIC016741-PA"/>
        <property type="gene ID" value="ASIC016741"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016741"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019638"/>
    <dbReference type="OMA" id="GEWIMSC"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRETINALDHBP"/>
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        <property type="match status" value="1"/>
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            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="324" mass="37452" checksum="59DC92211433006D" modified="2014-10-29" version="1">MTSAPEVDKCPVEYDSYRPVDSALHRQIARDELREEPTIVEQALRQMREWIAKNPSILACRTDAPFLLRFLRVRKFSHVAACDTLERFLTMRQRFPAWYGQLDPSEPWVQDVIDSEFLLPLGRDEKGRTVFLMRYPNLDIDRHDVVRQIRFFTMVFECLFEDALFGIGGLVLLSDYSNVTMKAFAQWSLTEIRNYIDCVTKSHPIRIKEVHVMNLPLFGATVGEWVMSCCSEKLRSRLKCYPSVDDFIQKTELKGMLPTTYGGKQDAAKLKQNLRDMLDRNKHIIVGLDDMKVDEKRATASHHPCNRADLDTGAVGSFRKLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFD2</accession>
    <name>A0A084WFD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016922</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC016922-RA">
        <property type="protein sequence ID" value="ASIC016922-PA"/>
        <property type="gene ID" value="ASIC016922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016922"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013541"/>
    <dbReference type="OMA" id="SPHGTIC"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016922-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1315" mass="139649" checksum="E73B42CFA55AA427" modified="2014-10-29" version="1">MYSADIDFMSNYVKNLPDYGGGDAASRRSQLPAAPLPPQPSSAFPPITTNYRQHYVNDPYYQYYDDVSGVQRFYPMFKSNSYHAYPYGGLEEQQAATLDYSRYAFVAPPAARHISGVVPPTTSVPSSSSPSTMALEQQLQRASLRSQPSASYATGSSVSLYQDPRNVGIPPSATFSSAEQLNQHQLQRSSSRTQPFASGVGGQNLQGPSEPQETLDFRLNGGNRPSTMVNQRSGSRNQFPSSTSSSAPSCTVTSGALAFVTSNTRPQLPTTPSSGQSRAANDAPNVSEGRIQNPPLDAPVVVSGSIESSVPATATNNITTSCSSDHHPLNNSSAYGGSTTTSLGLQLRQYQREQQSQAAKQQSSMSRFWQETTSNRPTGPPWRIGWDYNRIITNNRKEVHNTINEYKKNVTSSPHGTICGADGTAGQSPASSSTSSSSSLPMGSRTNIDATCGGGAGSEQQPGTNHLPLRLRKNYSYSHLDKHVRDHLTEEEFYRVVQEGESMPTYWDPHHSCQPWNYGAAGTGGTNIAGVPGGVFVGGMPLCKSFSSDAMGLHTLPPTPTTSSGTPISSLQQMLAYQQPLGCPAYPQLIPPVIVPQNHHHHHQHNQPGGVTTPLYNAGASATTSNVASQGSSASTVNPVESSSSTSRPQTSSNSSGKSPSTHVGGGRHSRLGGVGKPQPPSQPQPPLTSNISDNISVANMLISKNNNLLLQKSASFGKASGAAGTMLGRGNAGYSAGPSAPLSSGISPRPVPLAKSSSALAALPTTSGFGPRSPRPPQQQQPAPPPVPPIRANAPEPSTNVSSSSNGERNNVLMHTSGGGSRLNPDAKNFTPTHRQPAAPSCSSSATNVTRSNSGTFYVSRSGRIEPLPSATVIGGGTDNTDESNPHRIPTVMVSKGVFLSKSATQIVTYGDVQTPAEPSPQDDEDEDTTTIVPGPSSDDDDEEDDDEGEELDDDRHRRYHRHDDKDDRGGGGGGGGDGGGTSNGGSTYRGTDVGYPGTKEQHQKWQSSGKGAGKYAYDDEAGVDDTPSDSDEREDGELGSLSDADSTGAVQGDDHLPRYSRTPTMYPKSFDHYLLPAVGSGGGTKVSSRAIARHQHQLRLVPEQPKPPPRLYTSKSSIFLETVDGGGQTSRTTGLDPDQYQLLILGDNHDAEDEEEEEEVEEEEDDHDAEDEDDEVEEEEQEGAKALGVYHQSSKKATTGGSLRGPTKHQQHPVMYEDALSTTSDNQLAEEQCTPNDVEVEPLDPAPLTRLASFSHGGDAYPLLLVLLLALCEQLQEATQAHHDDDVRPVAVAIESAFAAATLTQPQQTPCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFQ0</accession>
    <name>A0A084WFQ0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Protein serine/threonine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00017056</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFQ0"/>
    <dbReference type="STRING" id="74873.A0A084WFQ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017056-RA">
        <property type="protein sequence ID" value="ASIC017056-PA"/>
        <property type="gene ID" value="ASIC017056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017056"/>
    <dbReference type="OMA" id="IMDETIR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB49044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017056-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="642" mass="71314" checksum="A29EF643E4170405" modified="2014-10-29" version="1">MKKSDSPWKNSMMDLFSNPESVELGPADKNPANCDLQACVMEVPPTPLVTALGYCTGVKVYVVKRQLATVERSPWTIQMLCPRNDPTQKQLFEKRLSKEAALLLQLKHPNIAGYRSFGGIDEARNFIALEYLTTSLGQILENRYNTNAGALEAYKTKRMIIHLLRGLVYLHESAHILHGDIKSFNILIKKDFENATICDFGASAPVDQEGFLDRKKAPEGRYVGTSLWSAPEVFSNNPHLICVKADIFALGMTIYETLTLTPPHTFAGIMDETIRASVDRRPLEMSLEGEEEDGYEEEGEFAEEEDQIADEEDQIADEEDDVPEEDDEVHGEDGEVHGEDGAEEGVACEAPKGEMLEMIGDEEIEALCKDIVESHKRKLADDGEEHLLKKRKTSGEESVADSVGGKSPTADEDALGNPSNDGDVPRDDEQKEVVPTSPIPEAETSFAGSDDSGRTIPMKGRTIPVSGSERRRDEQKESDPASPMIDPEVISISSDESVEERPRSGIVLEVASDSEFEEYYEEESDQEFASHADAEGEYEEDDYEDGQYLNYAVLGTRPPIPSSIEIGKEHLPLVELFYVCTESLPNDRPTARQLLDAMTKTMWEQGETDALEQQTVDDEKKPNEDGGRRIKAVGPRNTAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFQ3</accession>
    <name>A0A084WFQ3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017059</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFQ3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017059-RA">
        <property type="protein sequence ID" value="ASIC017059-PA"/>
        <property type="gene ID" value="ASIC017059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017059"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017059-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="152" mass="16570" checksum="E3185A4C96884A20" modified="2014-10-29" version="1">MEEKLTSESDFPKSVPFEGWHFQNSTVHARRARDVIESRREVVALAGSKIPTRCLSSAPMLDAKDCTATKNAGTSTIGTTSGRTRRTRSVSAGGVVGGGTLRLAATIPVAGEHRKLRSRTVAPREATKKRPIALRATLEGQYVSRRRWVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGK0</accession>
    <name>A0A084WGK0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00017348</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023587">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525344">
        <property type="protein sequence ID" value="KFB49344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGK0"/>
    <dbReference type="STRING" id="74873.A0A084WGK0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017348-RA">
        <property type="protein sequence ID" value="ASIC017348-PA"/>
        <property type="gene ID" value="ASIC017348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017348"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021420"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="12">
        <location>
            <begin position="505"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB49344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017348-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1016" mass="116321" checksum="3F6BADF4DB284181" modified="2014-10-29" version="1">MLRQVSSMKRFLPSRRFLTSTPAPKINPAVLANIKAADRYKPGDRYNGFVCIQAQFIADFNMTAYMFQHEKTGLQYLHIDRQDSNNVFSINFRTTPFDSTGLPHILEHNVLCGSAKFPVRDPFFKMLNRSLATFMNAMTGPDYTLYPFSSTNEIDFRNLQTIYMDAAFRPNLKYLDFLQEGWRLEHAELTNPQSDYVFKGVVYNEMKGAFSENSAVFGQKFFNKILPDHTYGYVSGGDPLDIPQLRHEDLVNFHQKYYHPSNARIFSYGCFDLDKTMAFVDGQYLSDYDRIDSRYSVIPPQKRWTSAKKDHVRSRYDNMGAPIEKQNQIAIGYLMTDITDVYETFLMHILTELLVKGPNSFFYKNLIEPNISGGYNQLTGFDSHIRDTMFVVGLQDLAVDDFERVEQIFDRTVDEVIEKGFEQAHIESVLHSIELTMKHQTTKFGLGLLFNLTPLWNHDGDLIRAMNVSESVRKLREHMSANPKYLQNKVEYYFRNNRHRLTMTMSPDETYDKQLLDAERRNLQQKVANLNDSDKERIYREGIELSEAQKAPPNTDVLPCLRLDEIEKKVSETKVEQRLVSNVPTQLCPVNTNGIVYFRGILDVNGLSEEQKMLLPLFNTVITQFGTKGVNYREFDQLVSSKTAGIGFSTHLVENIHNTEQYEFGLYFGTYALDKNVPDMFDIFRRIFNELEMTDVTRFEMLLENYLSEMSVGIAQSGHMYAMQNANGLVTETGRLRERLMGIEHLSFMKNLTQSHKPEEILEKCRSITKLFAEAGMRCALNFTPSSEEQTVRQYESFVKSVPLRSSARVWNISQTLGEGASSNTTCRHTVMNIPVNYCAKSILAVPYTHRDYAPLKVLAKYLSAKYLLPVVREQNGAYGAGAKITSDGLFNFFSYRDPNSRTTLDVFDGAHAWNVQSVANLDEQTLFEAKLGVLQQLDVPIAPLERGMDLFRQGISDELFGKHRAAVLEVTKEQLLEVNERYLRPGAVAVVGKSVLGPENKTLSKEGESWKTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGR1</accession>
    <name>A0A084WGR1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">WD-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017506</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023688">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGR1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017506-RA">
        <property type="protein sequence ID" value="ASIC017506-PA"/>
        <property type="gene ID" value="ASIC017506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017506"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017506-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7621" checksum="5E58F3B79458CD61" modified="2014-10-29" version="1">MTFACVPKDGTINPPRTSSKLIAPLGQGQQIATERNRLIADRVIVVWPPHDDYATTLQQLANAECSCIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGS7</accession>
    <name>A0A084WGS7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Membrane protein TerC, possibly involved in tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017524</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525345">
        <property type="protein sequence ID" value="KFB49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGS7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017524-RA">
        <property type="protein sequence ID" value="ASIC017524-PA"/>
        <property type="gene ID" value="ASIC017524"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017524"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017524-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8357" checksum="36161261976FBE61" modified="2014-10-29" version="1">MKEVEMEFPLEHAPPFENLDPGERACLEPMLGSRLEFFSEENLPSGDFIRFPRLRDRGYFAADHPSIGVDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WGW7</accession>
    <name>A0A084WGW7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AGAP008102-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">KIND domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ZHAS_00017748</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WGW7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017748-RA">
        <property type="protein sequence ID" value="ASIC017748-PA"/>
        <property type="gene ID" value="ASIC017748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017748"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011840"/>
    <dbReference type="OMA" id="PMANGEC"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KFB49461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="164" mass="17342" checksum="4F19691FC5F4678C" modified="2014-10-29" version="1">MASETETSVPACPPPPEALLERGGQCRKVSSKMAPRSDEGDGERVGKIGGGGVRRTEPTVDGGGPTANGGSVGVRGAVVCSGGVGTSVTLEEILKTFNAPISEDQAWALIFQASRMFKARLQESGCRLRDLRLPLHPNQLHIQKDGSCFVTAKTARQHLSPLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH81</accession>
    <name>A0A084WH81_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydrolipoyllysine-residue acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pyruvate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00017585</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01023795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH81"/>
    <dbReference type="STRING" id="74873.A0A084WH81"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017585-RA">
        <property type="protein sequence ID" value="ASIC017585-PA"/>
        <property type="gene ID" value="ASIC017585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017585"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000010"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013024"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017585-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="512" mass="54427" checksum="D70DB7AA0727D5A3" modified="2014-10-29" version="1">MLRTIIVRNENLLLQGSVRQVLRGTAVRALSSECAKRTASAGHHRRNSHTLSSNLKPVAWRVNFVRGYCSGFPAHSKVLLPALSPTMELGTIVSWEKKEGDKLNEGDLLAEIETDKATMGFETPEEGYLAKILIPAGQKDVPIGKLVCIIVENEADVAAFKDYKDTGAPAAPAAAAAPAPAAPAAAPPAPTPPPVAAAPPPPPPPPVSAGPMTAVEQRGPRVYASPMAKRLAEQQRLRLDGKGSGMFGSLTSKDLAGLQAAGAGAAASAPSAARPTVPAGAAFVDIPVSNIRGVIAKRLLESKTTIPHYYLTVDVNMDQINKLRARFNKQLEKEGVKLSINDFIIKAAAMACKKVPEANSAWMDTIIRQFDAVDVSVAVSTDRGLITPIVFSADRKGIADISKDVKNLAAKAREGKLQPQEFQGGTFSVSNLGMFGVTHFCAIINPPQSCILAVGGTQKRLIADKDSEAGFKESDFVSVTLSCDHRTVDGAVGARWLQYFRQFLEDPNSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH94</accession>
    <name>A0A084WH94_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Adenylosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH94"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017601-RA">
        <property type="protein sequence ID" value="ASIC017601-PA"/>
        <property type="gene ID" value="ASIC017601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017601"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017601-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="99" mass="11135" checksum="C163EE21B6336484" modified="2014-10-29" version="1">MWANNSELDEAASQSSASGSECDRDPRRSDPKVDSSWNVLSDPASMLSIRIQDQDTSHELFKRGERADRSGLGGKCPIYRRKISANPRRASKRVEPRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHK7</accession>
    <name>A0A084WHK7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00018204</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHK7"/>
    <dbReference type="STRING" id="74873.A0A084WHK7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018204-RA">
        <property type="protein sequence ID" value="ASIC018204-PA"/>
        <property type="gene ID" value="ASIC018204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018204"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021802"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB49701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018204-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="170" mass="18741" checksum="D468CF751237EABD" modified="2014-10-29" version="1">MVHPEFSRQNVAHDIAIVKLSSAIEMTDFIQPACLWTEDEEQFRIVGKLGTMVGFGNTEDDTVSEYLQEANLTVVEGLKCLEDARKSLAPILTSNMFCSRGTLGVSACRGDSGGGMFFKKNTSCGLGLSSLILVQHFEKDKVLISNLEGVRDIVLDPQRGKLYWANHGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHN7</accession>
    <name>A0A084WHN7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Odorant binding protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00018385</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHN7"/>
    <dbReference type="STRING" id="74873.A0A084WHN7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018385-RA">
        <property type="protein sequence ID" value="ASIC018385-PA"/>
        <property type="gene ID" value="ASIC018385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018385"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008025"/>
    <dbReference type="OMA" id="HQNAREC"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010760006" evidence="6">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB49731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018385-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="155" mass="17653" checksum="190888DE9E080A9C" modified="2014-10-29" version="1">MKCTEVITTLTLAVMLLGVTFVESARLEAEHIRRIHQNARECVKETGILPKNAFRVLSGDFSVDTMKAKCFVRCFLDKAGFIDDDGVIQQDVIREKLTVGIEQSKVNDLLKKCVVEGDDVCDKAYQMYKCFLNNHKVPKELFQLRKGVGRRNLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI33</accession>
    <name>A0A084WI33_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017903</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI33"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017903-RA">
        <property type="protein sequence ID" value="ASIC017903-PA"/>
        <property type="gene ID" value="ASIC017903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017903"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="72" mass="8038" checksum="C17A664DF0731D4E" modified="2014-10-29" version="1">MHPCVRLPVRQYSGQVRPSERTKGPFRGTIRVMLAHPTLTKVSLATSSGGFFIFLPQRRQCGFSTTAVGCWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIG9</accession>
    <name>A0A084WIG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Lamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00018055</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIG9"/>
    <dbReference type="STRING" id="74873.A0A084WIG9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018055-RA">
        <property type="protein sequence ID" value="ASIC018055-PA"/>
        <property type="gene ID" value="ASIC018055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018055"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021098"/>
    <dbReference type="OMA" id="VVNIKAM"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB50013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018055-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15922" checksum="2C0EC6FA7EC8FAA5" modified="2014-10-29" version="1">MSQKTKRSAASTPVPMQSSTPVQGSSAAGATHHHSGRPSSPLSPTRLARLEEKTNLQNLNDRLACYIDRVRFLETENSRLTMEVRTSQETVTREVSNIKSMYEHELSDARKLLDETAREKAKLEIDAKRIWEENDDLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIZ8</accession>
    <name>A0A084WIZ8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP012069-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018257</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023957">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIZ8"/>
    <dbReference type="STRING" id="74873.A0A084WIZ8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018257-RA">
        <property type="protein sequence ID" value="ASIC018257-PA"/>
        <property type="gene ID" value="ASIC018257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018257"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020793"/>
    <dbReference type="OMA" id="QGFQEDY"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="52"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018257-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="220" mass="25436" checksum="5A58621FA2141055" modified="2014-10-29" version="1">MVNREENIVEENELSLSNENDVSSDSSEEDVSTKHNDDIGPISDGSPIEKELFEDPEFPANNFSLYRWRDKSDNKEIKWKRPKQFKDVPKFFVEGFSRFDVRQGKLGDCWFLASCASLATVPELFVQVVPEENVEFDDDDYDGMFHFRFWQYGEWVTVVVDDRLPVNEKGNLLYGKTSTENEFWFALLEKAYAKLHGSYEALVGGLGEDAMVDLTVIHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJX2</accession>
    <name>A0A084WJX2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018556</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJX2"/>
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    <dbReference type="Proteomes" id="UP000030765">
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018556-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="232" mass="24872" checksum="B3F6934898D0282A" modified="2014-10-29" version="1">MWNEFCRSPASVISGPDPTPTTPGPYLPGFLPLLSPSADPIPIPLDRTCRLSPGALFTSLARFGRFRRSKESPAGLDEPRRSANKVTTTTSPPRYLRPCSRVGPKPRTGAGSKMAGDGENRPTAGIETSTPLDRSKPTPDRQTALGASHSGTSQVEFPEQTTVCVCVILVRVRSISASDPALKARAVRTTRNANRCAPTCSAGKGWIKQLHTASKESPEGSTLTRELHGKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="ASIC018971-RA">
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        <property type="gene ID" value="ASIC018971"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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            <end position="121"/>
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            <end position="154"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB50932.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018971-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="17724" checksum="EBEA4060328156F8" modified="2014-10-29" version="1">MEGKELSKDQLKILKDAFTAFDIEKKGSISVEVIGTILELLDYSMSEEELKEVMEEYDVDESGEIDFEEFIELASNYVEPEEDYDVLRAELREVFMMYDKDGKGFIPVDTFKQILRELDGAVPENELDDIIDEIDADGSKTVDFEEFMEVMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLD4</accession>
    <name>A0A084WLD4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00019077</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Mosquito</name>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ASIC019077"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019077-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9486" checksum="5D16F34334BCA720" modified="2014-10-29" version="1">MKNPAEMLRFRRMTTTDDDEQKRQPPRRRSHHRCRRAGTTPPGPNSALGATTVCRLPLFREKARTQAALTDSDTQFFGALFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLG8</accession>
    <name>A0A084WLG8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">NKG2D ligand 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00019116</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
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            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLG8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019116-RA">
        <property type="protein sequence ID" value="ASIC019116-PA"/>
        <property type="gene ID" value="ASIC019116"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019116"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019116-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="17946" checksum="6C3B8639BEED6417" modified="2014-10-29" version="1">MSGQGSQSALKFPSIAFRPSPTTAPMTKRPCFPSGNLSRRDLRVGTAPDRQIEINALGPSNRNHYCIAHCNKWCIFVAHRGRWSDGRGGGERHGSGWRPPDRDTTGLRGQEIVGERSSAEKNAEASTVAATAQAGDNVKHNCIKTTNPTMDAPTELARTGVQHKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMH1</accession>
    <name>A0A084WMH1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP006134-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00019893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMH1"/>
    <dbReference type="STRING" id="74873.A0A084WMH1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019893-RA">
        <property type="protein sequence ID" value="ASIC019893-PA"/>
        <property type="gene ID" value="ASIC019893"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019893"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022728"/>
    <dbReference type="OMA" id="NYQSGTR"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019893-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="315" mass="35730" checksum="BF95DC816B7C8942" modified="2014-10-29" version="1">MFRNSFQHGFLSVFTSGGSKPLGIWDVHAKNGHCRRLTDEDLRSLVFELVGVNVATTFMVAPCNPCPSLAIKLPFLVMHVKNLRKFFSFEVQVLDDRQSLRRFRFSNYQSGTRVDIFSSSMPMSLAPSWNELQINLADFTRRAYGTNYVETVRLQIHANVRIKRIYFCDRLYTVEELPSEFRLFPPVRPCRIAEMRAAAKHHKHPDEPIEMLRPPTPVEEVVASNQVEVPAETLVRPPTPVDEMVVSSQSEVPAGTSTNAETPATVVPMETVNDTVQSVVHFEETEDEKAEQTADEPMEQPGQQVSERPQNLNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMY2</accession>
    <name>A0A084WMY2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019646</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMY2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019646-RA">
        <property type="protein sequence ID" value="ASIC019646-PA"/>
        <property type="gene ID" value="ASIC019646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019646"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019646-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="11696" checksum="4512882E04622D7F" modified="2014-10-29" version="1">METATNAHRTLHPRKCILISACRAGETSGPPPTRCKDWPHTVKPDTYDTFHLEEHKDDCPHLGGTMQNTDTMTVTTAAFAHALALPSVPFIQRRLGRTMQCRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN28</accession>
    <name>A0A084WN28_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00019696</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01024557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN28"/>
    <dbReference type="STRING" id="74873.A0A084WN28"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019696-RA">
        <property type="protein sequence ID" value="ASIC019696-PA"/>
        <property type="gene ID" value="ASIC019696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019696"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS024419"/>
    <dbReference type="OMA" id="RNNIQNW"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="221"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019696-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="436" mass="50504" checksum="F20E825C60CD37C0" modified="2014-10-29" version="1">MADVRDILELERPVTPELTKEAKIVAKRPEGMHREVFALLYNDNKDAPPLLPTDTVSGYKKTKARLGMKKVRRWEWAPFVNPARTDGAVFHHWKRASDEQKEYPFAKFNKQLDIPTYTLNEYNAHLKTTKWTKQQTDHLFDLAKRFDVRFIIMCDRWERANYGIKSVEDLKERYYEVVGILNKVRNNGMEKKIYVFDAEHERRRKEQLKKLFDRTPKQVEEEQQLLNELKKIEARKKERERKTQDLQKLISQADQQQTEHHQKEQQQHQTQNQHQTTTQKKQDKKLNKKKIQQQPRTSKVDSVVSAVESAGIKFTDLRGTGVSLRSQKMKLPANVGQKKAKALEQALQEFKVDPNPPPIEEICVAFNELRSDMVLLCELRTALATCDFELHSLKHQYEVLCPGKTLNIPASLVNPAAEDSTGDGEGSAAMDCGMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNH9</accession>
    <name>A0A084WNH9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019869</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNH9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019869-RA">
        <property type="protein sequence ID" value="ASIC019869-PA"/>
        <property type="gene ID" value="ASIC019869"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019869"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019869-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="14355" checksum="1CB3587602016F6E" modified="2014-10-29" version="1">MYRLKTAVVNGGWYRIAESSDEVAICAKAQGSSSSSNPLRATARFSPSHGPVEAHEGVPAVSGHTTAVRMVQGPPSPSRWTGSTNGLPTGVSKRSTRKTPHGCHWSSAGEEGGSPQPLHSGLGPNAGRQIFSDQMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WPM7</accession>
    <name>A0A084WPM7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000091-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00020499</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01025102">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525369">
        <property type="protein sequence ID" value="KFB52171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WPM7"/>
    <dbReference type="STRING" id="74873.A0A084WPM7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020499-RA">
        <property type="protein sequence ID" value="ASIC020499-PA"/>
        <property type="gene ID" value="ASIC020499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020499"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001891"/>
    <dbReference type="OMA" id="QYAHPIE"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="214"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB52171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020499-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="370" mass="42450" checksum="F13C14D097ABE957" modified="2014-10-29" version="1">MDMDVGNVCVEPGATPGSSEEAADSERAPPQRKMSSPRATVAAPTTTSSIESQNPRLLSSLYSFLVIVSFFLIGFAAFRNTLTWHLQRFWGASGDFWQSQWDRFIDFTGDDPARLWVLNTTIFTMAVYWLFGGIYTLFDVSCRPTIIRRYKMQPGTNEPVDRRRLAKVIATVLMNQTVVGVPMAYCMYQAMRFRGLTDLRELPTFHWVLAELSFCIFIEEIGFYYAHRLLHSRHLYRHIHKRHHEWTAPIAITAIYCHPIEHVFSNLVPPFLGIFMLGSHVAVAWLWFTLVILSTLNAHSGYHLPFFPSPEAHDFHHLKFNQCFGVLGVLDRLHGTDALFRTTKAYARHIMMLSFIPAREAFPEPAKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ08</accession>
    <name>A0A084WQ08_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Salivary secreted peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525370">
        <property type="protein sequence ID" value="KFB52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020534-RA">
        <property type="protein sequence ID" value="ASIC020534-PA"/>
        <property type="gene ID" value="ASIC020534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020534"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005265"/>
    <dbReference type="OMA" id="RSFRDMH"/>
    <dbReference type="OrthoDB" id="8192785at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685:SF1">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785090" description="Salivary secreted peptide" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020534-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13040" checksum="237CD20B598EE820" modified="2014-10-29" version="1">MKCAIIFTVLAVLGVSSVAVAQTHNYFFGSRVPYDSLVNQTTVIQTSSFLRVKTVDVEYPLKGQRGRNITAIYVYDRLGGGRGGFASITGGGIGQNYTRIHLKTQRGNGMNFQVEIYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQQ9</accession>
    <name>A0A084WQQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP008656-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00020811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01025668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525397">
        <property type="protein sequence ID" value="KFB52553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQQ9"/>
    <dbReference type="STRING" id="74873.A0A084WQQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020811-RA">
        <property type="protein sequence ID" value="ASIC020811-PA"/>
        <property type="gene ID" value="ASIC020811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020811"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017352"/>
    <dbReference type="OMA" id="KSKDACH"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB52553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020811-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="16444" checksum="BD624C83D5801216" modified="2014-10-29" version="1">MVMGRWFGERTTSSRNSRFQREQFVTTHFEEARAASRRTDGNIVYNLSIYDLSETTRLSWYSSDDDIKMCIVKGKDEDLCQNYIRVLAIPSQGSLLCCGTNAFRPLCRTYSINGNNYTQELEKPGQAMCPYDPTHNSTAVFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQV6</accession>
    <name>A0A084WQV6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00020880</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025779">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01025780">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525400">
        <property type="protein sequence ID" value="KFB52600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084WQV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020880-RA">
        <property type="protein sequence ID" value="ASIC020880-PA"/>
        <property type="gene ID" value="ASIC020880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020880"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015475"/>
    <dbReference type="OrthoDB" id="10666365at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020880-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="304" mass="32377" checksum="E5DDD8D0ADCFE281" modified="2014-10-29" version="1">MKSHHPGRDRPSEAFGALSDNSELPSSSIFAASRTSPVSNHSSGSFFLGNTNGKCAQKHRTEKSYQGRGIEFCXXXXXXXWVLKRSDRRTNRRGKRNRQENKGANVRLGGKTRWPELLGSTIFALSTTRAQRSCKTVSSPENVPNHHAYVQYVDSDMYTGSGQGQTQMAYPVYTVGDYGSNGQQQYYTTGGNYNTTGTGTNTTATGHTDTTGTGNGTANGTATANTVNANGTVTTGSGGSSAGTTNQQQQQQQQQQQQYLVPVDESVLLGTASVNGTGNTSGAQQHPSDSSPQNMTVSSSSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSC5</accession>
    <name>A0A084WSC5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00021430</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026455">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525414">
        <property type="protein sequence ID" value="KFB53119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSC5"/>
    <dbReference type="STRING" id="74873.A0A084WSC5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021430-RA">
        <property type="protein sequence ID" value="ASIC021430-PA"/>
        <property type="gene ID" value="ASIC021430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021430"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022481"/>
    <dbReference type="OMA" id="ELPSTWM"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB53119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021430-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16067" checksum="C53AC11911E9ED36" modified="2014-10-29" version="1">MPSDVKEFLRQAAMQVGAGGSAGFVEVCIMHPLDLVKTRLQLQASPAAGASKSATYYNGVFDCIRKMAKAEGVFSLYKGILPPVLVETPKRAVKFLTFEQYKRFFMFGADKPTPLTFSLAGLGAGVTEAILVNPFEMVKVTLQANKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTD1</accession>
    <name>A0A084WTD1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTD1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021983-RA">
        <property type="protein sequence ID" value="ASIC021983-PA"/>
        <property type="gene ID" value="ASIC021983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021983"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="55951D26C9E6E388" modified="2014-10-29" version="1">MLPPPSARTSANCSASCSRHLELHEPQMQPLQDTTRQSLASCESMLAFEDEPTRTNLHGSDPDPPMAGSSSLKGSVLAERRQSQCCVACLLFSGAQIFEQMPEYLCRKSMRQVGALGKRKMGQEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTP4</accession>
    <name>A0A084WTP4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021824</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTP4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021824-RA">
        <property type="protein sequence ID" value="ASIC021824-PA"/>
        <property type="gene ID" value="ASIC021824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021824"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003364"/>
    <dbReference type="OrthoDB" id="7742153at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021824-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="257" mass="27958" checksum="FF3000540B383B2D" modified="2014-10-29" version="1">MFRQRFPQRTTYLPPATSDGTGGNRSTPGLLQFFNRQVTGKPSSTTTASIKPVPDSTETIIDVTQPAASEATTFRPLSTTPTRRRMKTRRPTTSAPRQTDDVLRSNPLGLIIPSSEQLNFFEQWQRQPYFGPHRLPSSSSTTTTTRPPQMVDFHFPQGSDEEKGSPKPGVFDPVTRLGMSTEATTTARWSSTQSSTSTMTTLTTGTKSVGTSTLSPPKVSVVPGATDTPLPPEEEEEEDEGGLGNRIDQKVLISLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUX8</accession>
    <name>A0A084WUX8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000013</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000059">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL639061">
        <property type="protein sequence ID" value="KFB54022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUX8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000013-RA">
        <property type="protein sequence ID" value="ASIC000013-PA"/>
        <property type="gene ID" value="ASIC000013"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000013"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB54022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000013-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="283" mass="31523" checksum="3A4FEB564B114312" modified="2014-10-29" version="1">MNAWRPQASAEVPVNPDTLQWHLLGGQEEWSRITDVVRRIMTLLREWDQERARLARERQEEAERAEPELAAARDAARIASRRAANDRRNASRRDTRARERAERERLNPTQSPSPVTAARRAAVAQRVREHRDRNPRAGNRRPGIRRSRTRSRSRSRSRRRSRSQTMTDTDGGSTVMAAPRLDPIGRTRASRRPTVQHPVGAGAPFRGQSSPVRTALNLAILRRLVAGVFGAERQKEAVAGSPTVPFRSRSRPAGNPPLADEASRDSLSPAEAAAATEATTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9V5</accession>
    <name>A0A084V9V5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Sensor histidine kinase, HAMP and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000087</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01000457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523882">
        <property type="protein sequence ID" value="KFB34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9V5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000087-RA">
        <property type="protein sequence ID" value="ASIC000087-PA"/>
        <property type="gene ID" value="ASIC000087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000087"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000087-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="113" mass="11946" checksum="0A2AFE3E5BA79202" modified="2014-10-29" version="1">MTSLFLSLCTPFDSGHNFHSDCVRKKRKIKRHGGRSWECSSRSWPNRDHGVNANGARAGGKLSMFCDQSATFAGIGISTFGTTGSETHDDVVTLGTGSFPVGVVRAPDGEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084V9Y5</accession>
    <name>A0A084V9Y5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP010730-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00000163</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01000833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE523910">
        <property type="protein sequence ID" value="KFB34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084V9Y5"/>
    <dbReference type="STRING" id="74873.A0A084V9Y5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000163-RA">
        <property type="protein sequence ID" value="ASIC000163-PA"/>
        <property type="gene ID" value="ASIC000163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000163"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004655"/>
    <dbReference type="OMA" id="VIGRANC"/>
    <dbReference type="OrthoDB" id="5949700at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783247" evidence="9">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="93"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000163-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="348" mass="38319" checksum="4B3055A0D5736406" modified="2014-10-29" version="1">MRAFVIFVILVLALVIHGELGNNELKCAGGICVAKALCPNGTYIGNAEFAQQQNIITVRIDDYDDCEDYLLTCCKTSASEIDVDPQFRKFGELCGQTNEDGLFYNLHSNETVAQYGEFPWVAYILQLEETSSSTIFVCGGTLIHPRHVLTTAHNVDGKSNLIARFGEWDKGTDKELYPHQDSKVIDIITHGSYKLSPIQNDIALLFLEKEVLYQPHIQPICLPQEFNVFDGQRCIANGWGTVKGVYATILKKISLPVVPRARCERMFQYALVDPSFHLPNGFLCAGGEANVDTCKGDGGSPLACRQPDGNFVLAGIVSWGIGCGGQDRPGVYVSNISYHLNLFVELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBG7</accession>
    <name>A0A084VBG7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013213-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001584</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524386">
        <property type="protein sequence ID" value="KFB35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBG7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001584-RA">
        <property type="protein sequence ID" value="ASIC001584-PA"/>
        <property type="gene ID" value="ASIC001584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001584"/>
    <dbReference type="OMA" id="PETPMIK"/>
    <dbReference type="OrthoDB" id="10465606at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001584-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="183" mass="20305" checksum="E072906510DF62D3" modified="2014-10-29" version="1">MFNALKDQALEIDSKIGRLRKHCTTFATGYVEEDASKQDSVREKLTAAGNELRDTITDCDRLVEQTHALFTLLTEADKVADEIYDSVIKLYLEQGVKVPPIDLDTIAVGFPIDLLPLPEPSSVVNRSAGSDSENEAAEEEEHSTDDSEILAEDFEAEVHISRLPGEDSLAPETPMIKSRKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBI1</accession>
    <name>A0A084VBI1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Gag-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001617</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01006977">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524391">
        <property type="protein sequence ID" value="KFB35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBI1"/>
    <dbReference type="STRING" id="74873.A0A084VBI1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001617-RA">
        <property type="protein sequence ID" value="ASIC001617-PA"/>
        <property type="gene ID" value="ASIC001617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001617"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000841"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001671"/>
    <dbReference type="OrthoDB" id="7744392at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001617-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="349" mass="38175" checksum="F5D7989F599FFC3E" modified="2014-10-29" version="1">MPPKANTTFAEVVAGPSRSQAESTGVPPRRAAESTRPTMKGRPEVITVTPPEGTSFLDVFRNVRSVPDVAECVRTGSRIQRNTAELVLKGNADAKAVFERVKALAPEGSRTTLRLDTVRLLIRGIDMLAEKSDVASAVGGKVGEVVAEEDVTLQRYYRGDQRAFVKVHRRTANALLGEKLLIGHSRCRVELAPRVSMERVTCSRCWQKGHLPAPATAPTARHLPRSATAQDLLVQLARERGADVALLSDYHRVPANNSNWAFDPATRTAVVALGRFPIQRIVNVAEGMVAVEVNSITFCVLVWGGGGGSRFRSVHGFAPRVALRRHWRKTSKATDETTRILHPMIFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBK4</accession>
    <name>A0A084VBK4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Dgri\GH23625-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00001817</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01008045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524450">
        <property type="protein sequence ID" value="KFB35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBK4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC001817-RA">
        <property type="protein sequence ID" value="ASIC001817-PA"/>
        <property type="gene ID" value="ASIC001817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC001817"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC001817-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="106" mass="12459" checksum="B07803D0FBF76A1E" modified="2014-10-29" version="1">MCREYLENRGQRLSSDNEHTRWNHPRSIVPRATSVYVHSNLSDRLRLRRRRADPLYPLHNKKLQHRSSYRHLIGGMHDHAQQQTPQPSTGSRKMSSHGSSINVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VBQ9</accession>
    <name>A0A084VBQ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002033</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01009030">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524498">
        <property type="protein sequence ID" value="KFB35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VBQ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002033-RA">
        <property type="protein sequence ID" value="ASIC002033-PA"/>
        <property type="gene ID" value="ASIC002033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002033"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002033-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="12609" checksum="652192E6D5ED4075" modified="2014-10-29" version="1">MQQGRDSKRVYIQSNALFPFRSYGGIVLMRQVRPSGGSDSMRAAIRGSGSGEDIMIAPDSCFYSRSIASFTTCPRCADLGGSPGFEGCPSATSGVDGFGWYSRIRFLTPSDNAASDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VCI2</accession>
    <name>A0A084VCI2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP004099-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002559</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01010760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VCI2"/>
    <dbReference type="STRING" id="74873.A0A084VCI2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002559-RA">
        <property type="protein sequence ID" value="ASIC002559-PA"/>
        <property type="gene ID" value="ASIC002559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002559"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013303"/>
    <dbReference type="OMA" id="ASQCEVW"/>
    <dbReference type="OrthoDB" id="5959043at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002559-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="463" mass="51003" checksum="9BF93520DC13E55E" modified="2014-10-29" version="1">MDSGNMRKRVPLFVLDSQLSLPSADYTARRTQGDGMENEDFAPAISAKRTSTTSTTSSSVASADVKLPVNFSIERLLPHSGANPVYRPTELVTGGNTSLAAVVPRGKVFNLVPRLVSTGTRSKLSTMHNKEPKFVPFEPYKGAVTPIIPGRNSIPGGGSRVKLSNRNNLDLSVLVSQMSTITDMELRSKSLPSTADEEKLRYEKQLEELRKERDYFQGQLKFQAQVNAELKNLLVAAVGEDLQTKVNVLTEDKLHLARKLLNSAENLSSHTEQIEFLAGQSEVWRSKFLASSLMVEELARWKTSLLQRNGLLLTSNKEQLEVISKTREMTIDVLKQLRFLANLKDPLQLQSATVLDLAAECVNISQLLALQHSALGMPDNLIGLTELESMTEAEKLAVQALQHSNQSLVPTDDAFRAIVGQAFPSIHSIRQQQHHTDTSLMSAGSDFELIANPDSETINESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VD25</accession>
    <name>A0A084VD25_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Disks large-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00002820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524643">
        <property type="protein sequence ID" value="KFB35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VD25"/>
    <dbReference type="STRING" id="74873.A0A084VD25"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002820-RA">
        <property type="protein sequence ID" value="ASIC002820-PA"/>
        <property type="gene ID" value="ASIC002820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002820"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013282"/>
    <dbReference type="OrthoDB" id="10023951at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002820-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="95073" checksum="47762E458688F419" modified="2014-10-29" version="1">MSDSEEENAGPSKEHHSKRINVVGSNSKLLLISDQYQQRLHRLREFQQQKEMLRKKKASQGAPFIPYVCSARIRDEVDCIRKDARALREVQLKPTDEALHKKRVSPSHTKFAKPRVDCWWTDGKRDAGKDVQRLAGGKEEAGKGADRFAQPITFVKPTKKAKETKNAIKPAKNRLNIENVVNHLARPQTKLITSTARKDKGKPLAFTFDPPSGLGGAKQKNTLTVADADSLFDGISPIDPIEDPTPHKKSVLPKSNHEGESIWEPQPVAGILEATAIDCETGVILINDDSPVVEKASERKAVLNESFTICDAPDRTIENAEDSIFGCRPIITDEQVSIVSDIKESSPLTVAAEKQDTQPREVSNKTVLTTNRRSSIWSVTLVSGVDVPSPSFENVPITGISPDEPKQIDTSASSRKRSSLAFTEENINTVISPSVSNLQSEPANSMANSKRRSSSSSSGPVVIQEGEAEEQPAVPPEEVLQKTNFYYQKVDSELARLQALCSEFAPFLEGEHELNDHCKGLIMAAQGQTNILINKKLTKFRDLIGHYKTKWNDRKVRNDDLDGFWLMVSLDLDNLDKRFAELRTLRENNWKESDPEPPPKEKKLQGAGVKKRAKKATVGSGGASKPSSSIAALIRKARQEQLKQKAANIDLGELAETVTLVKTPVRKSVRIAASPRRRSLQKRSSLGAGGTPTIIHWDHNPSPASRKRKTIFPETPKIADKRRAKSVLFLDSGLDTPQTRRRQSSRTVVDTPKPKIKFNEELEIEHIDNLVARTPSRLDQELQKRRRQSLLLFSATSSDLEKQDNGQRSNNNPCGTPKSFNSSKRRNGTSSRNLSAVFWNTEDDVFLEPDGKCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDE1</accession>
    <name>A0A084VDE1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP011412-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Protein quiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00002967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01011272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524660">
        <property type="protein sequence ID" value="KFB35985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDE1"/>
    <dbReference type="STRING" id="74873.A0A084VDE1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC002967-RA">
        <property type="protein sequence ID" value="ASIC002967-PA"/>
        <property type="gene ID" value="ASIC002967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002967"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014092"/>
    <dbReference type="OMA" id="SCKDPFN"/>
    <dbReference type="OrthoDB" id="9988013at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23589">
        <property type="entry name" value="TFP_LU_ECD_Rtv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF22">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB35985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002967-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="141" mass="15803" checksum="5B1EF8A2BAFFED01" modified="2014-10-29" version="1">MLFMSHVTTTSALLKRCYQCRSRSELGSCKDPFLLNATQVENERGVSAVPCASGWCGKVIEGMGSFKEDDYDMATQRMCVQRGPSDSEDRCAYTVYNHKKVYMCFCQGDLCNGSDRLHRGRKWIGLTKATLISLVILRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDF4</accession>
    <name>A0A084VDF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP007181-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00002977</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011323">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01011324">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524662">
        <property type="protein sequence ID" value="KFB35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC002977-RA">
        <property type="protein sequence ID" value="ASIC002977-PA"/>
        <property type="gene ID" value="ASIC002977"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC002977"/>
    <dbReference type="OrthoDB" id="8062808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC002977-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="55" mass="6225" checksum="F180398543C09DF1" modified="2014-10-29" version="1">MNRSXXXXXXXSVSIAERLAALKKSGEDDWRKRVSKKDVPTTCAGRILSMRVLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDJ9</accession>
    <name>A0A084VDJ9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004409-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003070</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524695">
        <property type="protein sequence ID" value="KFB36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDJ9"/>
    <dbReference type="STRING" id="74873.A0A084VDJ9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003070-RA">
        <property type="protein sequence ID" value="ASIC003070-PA"/>
        <property type="gene ID" value="ASIC003070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003070"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008862"/>
    <dbReference type="OMA" id="PPAWETK"/>
    <dbReference type="OrthoDB" id="5865303at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045400">
        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045460">
        <property type="entry name" value="Wolframin_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045458">
        <property type="entry name" value="Wolframin_Sel1-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20053">
        <property type="entry name" value="WC-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19914">
        <property type="entry name" value="WEF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20023">
        <property type="entry name" value="WSLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin EF-hand" evidence="3">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="4">
        <location>
            <begin position="661"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003070-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="770" mass="87021" checksum="3DB5EC86449FD235" modified="2014-10-29" version="1">MASWANRPPIESNGGPSSTRKKWNLEDKKSLRNLKYHFAEDGCSEVQFTLAKQLLEENSETDPAHNHAQGVHWLLRAAQQGHEASIELLKECFENGRGITEANEEDVRSILAMSPSERSARRAAQELFASLSNGEEYVTAAQLEKRMREIYKIDRRRRRTQPDGAEADGSVEHSGSAGGTPERPGGSSTNQDGTPLGSSNGNRLHRSPTVNHISEANLLAAAVNYSNGHLPTVSDALMLSVPDPHSLNHVPCFHRPFFHPIVFFQLLYHRFLLLMSTFPGSVGGTWLQLVLVLTTYWYFASENFLSLVPVGGYYVSLAVMVLCSFRMLKSKHDFIDFRMWSGLFLRYGDEHLNTNEPENQYLRNNLKPYLYFFVAFFVNMMLQPNISDQWLPFSEITVLAFALTFLTMFAFTYTAGDPFPDYLILFSFGLNVLAKYPYEMDEVVTTGWRFLDLKVPGFSTFVIGNGIEFCLNCRAMLYLMIPGFLMYIARRNSWRGIYQYLMPHCVTLAWLQICIISSQSATMFGLVRGALGLSGLLLFLPLFGIVTLLIPVFAVIEWLSLTDSTVRLWSSIGAAVTAVAISGYMASSRRTERYITFLQIAICVIGTVFLTLPHMMSNFETIGGTEGRLYEPTPTSDHLGHHHQNPSHTGDSAERPASLSWDLYYKFCHQPAWDSENKVKTQLRCTNLDGTYVRWEGTVLDMAISSRRNLRAELIEGYLPKFLADRINCLYGEPIEPDCGNLNGSSEGDCENLKHFMQRQRTCHLNKWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDM5</accession>
    <name>A0A084VDM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP005435-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00003099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDM5"/>
    <dbReference type="STRING" id="74873.A0A084VDM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003099-RA">
        <property type="protein sequence ID" value="ASIC003099-PA"/>
        <property type="gene ID" value="ASIC003099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003099"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006286"/>
    <dbReference type="OMA" id="SYLENMV"/>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032553">
        <property type="term" value="F:ribonucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000004">
        <property type="entry name" value="Iodotyrosine deiodinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003099-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="311" mass="34942" checksum="3710A6E9299942FF" modified="2014-10-29" version="1">MASYLENMVDWFLSTSALVTYWNYIFPVLVGLYLAISLYDKHRYGSKKQLRITSSPRDGSPAAGNGAKLDGMEYVGELEQADYDPLPALEDKPHVPYVGATVTLAKDPLEAANRFYEIVNDRRSVRQFSRRPVDAAIVERCIQAAGTAPSGAHTEPWTFCLVSDSSIKQSIREIIEAEEFINYTQRMAKQWVTDLRPIRTNHIKEYLTEAPYLILIFKQTYGYKTDGGKKQHYYNEISTSIATGILLCALQSAGLSSLITTPLNCGPALRNLLERPPNEKLLVLLPVGYAAEDCTVPDLHRKSKEDIIVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEN9</accession>
    <name>A0A084VEN9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004298-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00003602</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012285">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEN9"/>
    <dbReference type="STRING" id="74873.A0A084VEN9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003602-RA">
        <property type="protein sequence ID" value="ASIC003602-PA"/>
        <property type="gene ID" value="ASIC003602"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003602"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008941"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003602-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="196" mass="22030" checksum="57B77BFC4E5577D2" modified="2014-10-29" version="1">MVFFSTALGNETSLPMELCSNFDADEIRRLGKRFKKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVKGDKLSKLKFAFRIYDMDNDGYISNGELFQVSGEKSQIAVTKIIRYVAAVLKMMVGNNLKDTQLQQIVDKTIVFADKDEDGKISFDEFCSVVGNTDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VG08</accession>
    <name>A0A084VG08_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002065-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004071</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01012594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524806">
        <property type="protein sequence ID" value="KFB36902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VG08"/>
    <dbReference type="STRING" id="74873.A0A084VG08"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004071-RA">
        <property type="protein sequence ID" value="ASIC004071-PA"/>
        <property type="gene ID" value="ASIC004071"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004071"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004990"/>
    <dbReference type="OMA" id="GNMIMEV"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004071-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="245" mass="28180" checksum="A47546996926AD38" modified="2014-10-29" version="1">MKTANAGSDSIHVGNGVEETAELRTASIATVKQWLLEERPELQIPTESKLILYFLRTTKYNIEKTKQKMSTFLKNREKLTEWFKDRNPRRPEIQELLDIGVFLPLHQKDALNRQVVIIRTSAHDPQKHKQDNVFKVDKMILDLLMYLDETVSIHGVVAIFDMQGVTLGHALQLSPAMIKKSFMSAKMKERVTISRKGSQMENLITLPRELGGSGESYQQLAEHWKETVQANESFFAQMEQNVFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VGG1</accession>
    <name>A0A084VGG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004251</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524824">
        <property type="protein sequence ID" value="KFB37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VGG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004251-RA">
        <property type="protein sequence ID" value="ASIC004251-PA"/>
        <property type="gene ID" value="ASIC004251"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004251"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004251-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="110" mass="12370" checksum="D478EFD9A8B8096A" modified="2014-10-29" version="1">MDAPPTKPNNLVIGPEPLKCRKERGRYRSGRVTFALRSSASHLTLTKQRKSTRKLDFSPTALMAGRSPPPHWLADKHFSWTQVAAAIFTPLLTPTHGDTLRYDLTVTVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH68</accession>
    <name>A0A084VH68_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00004690</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524842">
        <property type="protein sequence ID" value="KFB37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH68"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004690-RA">
        <property type="protein sequence ID" value="ASIC004690-PA"/>
        <property type="gene ID" value="ASIC004690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011338"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF18">
        <property type="entry name" value="PROTEIN TWEETY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="357" mass="38863" checksum="94C64F7C74B9B0A7" modified="2014-10-29" version="1">MRARREDQLPPECAYPANRNARVPRGVKIYGITCGPDSSWLADEVREVSTFRKGESTFPPATKDAFVPKLKDVQYTYCSTVGTNRYVLRLNESKVHVDRAKESLETVNSIGMDLYPGIQISSKVNKINGELDDSKRQLTALSVMLDRRTVAEHYADATRSLCEGGLLGLTLMLLASLVSAAILSLLVCVDSHTWIYLTKKRPGYEDKAETTPLFPAGANASPSAPIIASGTMTVNRTLLHAQAATTNGSTVGGPAVGGAGATGTLIPTSGRNGTTHGMRGFASYSGDESPPPDYNVVVHDNRHGFFVLIFALSYLLLGSGSLGRRLRLECLYGHRHLFRCFTLHFKQPPETGRRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VIG9</accession>
    <name>A0A084VIG9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005078</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ASIC005310"/>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VK47</accession>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014110">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524943">
        <property type="protein sequence ID" value="KFB38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VK47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005694-RA">
        <property type="protein sequence ID" value="ASIC005694-PA"/>
        <property type="gene ID" value="ASIC005694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005694"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005694-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13491" checksum="2DA087F16BCEC4FF" modified="2014-10-29" version="1">MKVNEASARGSTGCAFNQRKRAHLDPLDAARRHVYSIFPPPGHVRETWIVDSPKGCCKMVDFEGVFECACAHVLADAMANDKGTTADTWVGRNTSLTFANAAASTVVLRVLLHSGQHYGKDMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLU4</accession>
    <name>A0A084VLU4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP000121-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00006261</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01014556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01014557">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524974">
        <property type="protein sequence ID" value="KFB38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLU4"/>
    <dbReference type="STRING" id="74873.A0A084VLU4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006261-RA">
        <property type="protein sequence ID" value="ASIC006261-PA"/>
        <property type="gene ID" value="ASIC006261"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006261"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001385"/>
    <dbReference type="OMA" id="THIEVVA"/>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06667">
        <property type="entry name" value="PDZ2_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06791">
        <property type="entry name" value="PDZ3_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06668">
        <property type="entry name" value="PDZ4_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF20">
        <property type="entry name" value="PATJ HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="589"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="755"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006261-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="858" mass="89473" checksum="E11F9FC5512A444E" modified="2014-10-29" version="1">MVLSTEWSQVEIIDLINDGNGLGFMLVGGRSTGVVIKALIPGSVAERDGRLQSGDHVLQIGDVNLRGFSSEQVATVLRQSGQQVRLIVARPVEPTSPDYQAIASHAPIIPTKMLTDPDELDRTLLQTAGYTSGAFLQPMVGGGGDGGGAVDGTNGGTTLPALAPTTLGLLAAAGESVSGGTAGGGLCPTHIEVVAVNNSFNSGTLIEQGLHNGTLISPASTVTIPPGQLAQVVNNFNKPMVATSDKGTINDHIEPASTPQSPYGELLGGPPDTPETETYEVELRKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAEMSGKIAINDRIVAVDRRSLAGVTNHQAVEILRNTDIAVRLTLERFLRGRKYEHLQVALIDPVPMAVPCHATSGPNSSAGKIGCSQERILSNGSSHSVALHDHDGGGGHYVAGELGEMVTSYSQTLSHCASQCQSQRCSIVQSPSATTLSICPARSDADSIVTECGGYDCGTIEPELESGTTFDSSVFALEHCTAETLSGDDGEVGDPALYENSTVIAAAAAAAAAAASAAVTAPPTSVNNTARGREVVVAAAAAADPVVERWAREVPHSQIVIADIRKLAGLGISLEGTVEVEGGVEVRPHHYIRSILEDGPVGRDGSLKPGDELLQVNEHRLQGLKHIEVVKILKELPAQVRVICARGSSPPTVINTSRNAEAFEARSLLAGGLQSLQSLQGILTKAQSESSLYTSSTATLTDQQRSKSVEQVSGLALWTNEVLYCDIEKTERGFGFSILDYQDPLDTEGTVIVVRGLIPGGSAETTNFIFPGDRLVSVNGHSLQSATLDQAVSILKGIPLGPARIGLCRPLSTSDNNLSSTPETPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLZ6</accession>
    <name>A0A084VLZ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP009376-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLZ6"/>
    <dbReference type="STRING" id="74873.A0A084VLZ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006660-RA">
        <property type="protein sequence ID" value="ASIC006660-PA"/>
        <property type="gene ID" value="ASIC006660"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006660"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012769"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006660-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7141" checksum="7404F59B5758A398" modified="2014-10-29" version="1">MAALKFDENKVPYLDLGNGYRIALEGEEYTDAISKEKAARELRETPDVVEKSLQELRSLLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMT6</accession>
    <name>A0A084VMT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014625">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006632-RA">
        <property type="protein sequence ID" value="ASIC006632-PA"/>
        <property type="gene ID" value="ASIC006632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006632"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="75" mass="8620" checksum="43505F156B3FCD06" modified="2014-10-29" version="1">MQINPTIHQLKFVSSTSRAAPISEKPMLHHLLEVVRTNHRQLKNAVQNRDAREEEEGTSRPKFCGGKLSPTLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMY8</accession>
    <name>A0A084VMY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00006690</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMY8"/>
    <dbReference type="STRING" id="74873.A0A084VMY8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006690-RA">
        <property type="protein sequence ID" value="ASIC006690-PA"/>
        <property type="gene ID" value="ASIC006690"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006690"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000381"/>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB39332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006690-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="292" mass="33481" checksum="FABBF57ACEBDE034" modified="2014-10-29" version="1">MNLTYKLNTGFTIPLIGFGTYQIHGRELIYEVLDYALNAGYRHIDTAVVYRNEEYIGSALKTLLPKYNLKREDIFITSKLISQSNKDEQCVEEMVRKSLANLQTDYLDLYLIHWPGVSGMQVNHPDNVKYRKATWNALCKMQKGGHLRSIGVSNYTVKHLKEMLAECNGIVPAVNQVEWHPYYYQPELLDFCRKEGIFLQAYSSLGSSNTTELRSDRTVNDVASRLGKTPAQILLRWAVQQNIGILPKARSRGHIEENAALEFEIPAEQMKELNDLRHTVGRKFAWNPETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN52</accession>
    <name>A0A084VN52_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP000351-PB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00006823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN52"/>
    <dbReference type="STRING" id="74873.A0A084VN52"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006823-RA">
        <property type="protein sequence ID" value="ASIC006823-PA"/>
        <property type="gene ID" value="ASIC006823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006823"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013774"/>
    <dbReference type="OMA" id="QICCCIR"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF73">
        <property type="entry name" value="RYAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB39396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006823-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="105" mass="12147" checksum="89A5C4F5AD864A5E" modified="2014-10-29" version="1">MIKMMVTVVIVFTFCWLPFNFLMLMKLEASWDLLPYFWFAFHWLAMSHSCYNPIIYCYMNARFRSGFILVLHGVPGLQQICCCIRHSPPAIARNVGSSVALAGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VND9</accession>
    <name>A0A084VND9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP008044-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00006978</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VND9"/>
    <dbReference type="STRING" id="74873.A0A084VND9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006978-RA">
        <property type="protein sequence ID" value="ASIC006978-PA"/>
        <property type="gene ID" value="ASIC006978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006978"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010199"/>
    <dbReference type="OMA" id="RSIFFEH"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="220"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="14">
        <location>
            <begin position="550"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB39483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006978-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="718" mass="78849" checksum="7BD5A5362817A8EB" modified="2014-10-29" version="1">MLSVSRVAIGNFRKVHTTVVRKHVLAGGCSQTLVGRRWFSRKVKYALMVKESGSRRRYAARAKEDTVESCDCPDEENVQELNSSVKNQIPTFSTSDNRRRIPMMGELIQFPNDSNPYPAPPKPRVLISSFSKETAHKSVATQGGPSCPPPPPPPPGQSYTGYLLGAIALTAGGLGLAYYNGLFDSTPPPTPVDDTKEKPSPQKGPYPLSSKDLPKHVPYLLIGGGTACIAAFRSIRGHDPKAKVLMITNELEMPYMRPPLSKELWFSPSESEPLKFRQWNGGERSIFFEPNDYYIDPAKLSDAPNGGIAVARGYEVQRLDVTKRKAILTDGTEIEYDKCLLAPGARPKNLPVFESAPLAVREKVTLFRSVRDFQRLTEKLGDGHKVAIIGGGFLGSELACALSKSEQTSKKNIEVFQLFNESGNMAKVLPEYLSHWTTERLREEGIKMWPKTQVKAAEMQGKQVKLTLLDDSVLLVDHVIVAVGSEPNTNLAKTSGLEVDGNMGGFVVDAELRARSNVYVAGDAACFYDTKFGRRRLEHHDHAIVTGRLAGENMVGLNKPYTQQSMFWSDLGPKISFEAVGLVDSALPTRAVFAIRSVEDLTRAVAGATIGNDSAKLQAANANGEIKSVTPAEGGSKSEGADNNRTQEVSEKEEDGFNKGVVFYLRENKVVGVLMWNVFNKLGIARKIVDQCTEWDDLNEVAKLFHLHGPPAEEDDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPY3</accession>
    <name>A0A084VPY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007486</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007486-RA">
        <property type="protein sequence ID" value="ASIC007486-PA"/>
        <property type="gene ID" value="ASIC007486"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007486"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007486-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="154" mass="17414" checksum="90CC655B762BB878" modified="2014-10-29" version="1">MIIRFNSSPTEDYLAPAPARREPKYSVTMANIATSRPESRTILDTSRSGPDDRKRSKRKGNRSLSEPEMLSGLKIRAGPAKFHYIIYHPPRCGERVCLAAEVPWVHPGLFRTVRNNIIALGAAKRHPLRPSDLSLSCRLEMRKIWLQPTAVVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRP2</accession>
    <name>A0A084VRP2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008178</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRP2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008178-RA">
        <property type="protein sequence ID" value="ASIC008178-PA"/>
        <property type="gene ID" value="ASIC008178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008178"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008178-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="112" mass="12013" checksum="D20C999F6A9875A6" modified="2014-10-29" version="1">MKAQFGTTHEGGLLVRGWCLRWEQILIKPPQGSSRPPCPNPPVANGTGLDGSGLAGQVHQHSNPQSGTPLSLSTFFPTHLGTIAIVEGKETLIELDYSPRCGKVSGQRRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VRZ7</accession>
    <name>A0A084VRZ7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00008168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525036">
        <property type="protein sequence ID" value="KFB40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VRZ7"/>
    <dbReference type="STRING" id="74873.A0A084VRZ7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008168-RA">
        <property type="protein sequence ID" value="ASIC008168-PA"/>
        <property type="gene ID" value="ASIC008168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008168"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010649"/>
    <dbReference type="OMA" id="IQLEANC"/>
    <dbReference type="OrthoDB" id="26518at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="362"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008168-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70549" checksum="03097442EAFFC068" modified="2014-10-29" version="1">MDARIGLEYIIENNDYVNKLGLALDTNNVTVKKQIFELLSTLCAFSANGYKRAIETLEHYKTIKNERYRLHLVVSELDKATTVEYQIALLAFVNCVIISAGSLKDRIRMRNEFIGLNLIPVLNNLRRTASNVPDIASQIEVFDEQQECDVAQSLQVPDGIDLNSHLDVFNAILAQVAGTPQATPFLSILQHLLQIDPKEQISDIVWDTAETLVHRATLLEDKEASARLLRAPSVQKFFTCPHCRGDLSGGPARRPSIGSSLQPSPSTTFSPPPPPPPLSGAPPPPPPPGAGAPPPPPPPPLAGGGRVPPPPPPPMAGGPPPPAPPAPPGGPNLLSVQAAGGGSLARSKTPDEPVEIIKPLPQQETPVPRAKMKTINWNKIPPQKVLGKQNIWSIVADSHQDSPMADLNWDEMEGLFCLQTQTQGSPKLGNRSTSADGSNGTDTPDSRKSRKENEITLLDGKRSLNVNIFLKQFRTSNEDIIQLIRNGEHEDIGAEKLRGLLKLLPEVDELEMLRAFDGDNNRLGNAEKFLLQLVQVPNYKLRIESMLLKEEFKANLMYLEPNINAMLFAGEDLMNNKPLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRTPPCWSSRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSI8</accession>
    <name>A0A084VSI8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP010934-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00008467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016041">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525054">
        <property type="protein sequence ID" value="KFB40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VSI8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008467-RA">
        <property type="protein sequence ID" value="ASIC008467-PA"/>
        <property type="gene ID" value="ASIC008467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008467"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000303"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005004"/>
    <dbReference type="OMA" id="NAFVFAN"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1612"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB40932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008467-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1799" mass="206285" checksum="BD9DE427DB661A09" modified="2014-10-29" version="1">MEGNLVETLFEAITVGDEQQVELCLKSATIATVLEFESVYGESPLHLCVKLGGVSHLGLVRRLLASGLVDFDQRDNEGQTVLEYAYQSGDQELTKQLIGVEIEGLDDATACYKMMKHDSLDLFKLFLSMKNMSEDETFKNIASAFAKLNVKNFVLSKELRLFAQWKLSDYAYRNLSGNWPGVKDPAEWKIHVDNIDDCWLLISAKYDTRLYDDVDDQLLHRLHVIHNYLYFLKHKQFLNHLPMHEIVFCVAMFISVFKSSAQSDEYRLLVNKRLVMDFVRMIHRQLKLAKKHLEIVEKELSTIMQEAQQLDSHTKNRLIEVMLEKLKATNFPNKDHWIAETTKKIYGAEGSNKDVLIKDLIKKIKSSDKMHLSKAVQAIDEENKRHLIDEICKRGLHVTHPQNVANRLIAGWKKGKTIDATVVETVGEESIDLRHLLRGKDRRIIRKIKTCYTKMKQIYSLHKALHYCKEINLDNELETNASLDSVTLVACTMRMIQVFGEAIKNTQNSPNLPGKAKSAVERMLSALFPLINISLRETISHSVSFKRILVDEACHRKVFETSKQNLRTVYISFLLLYVVALIEARQSFYGLMRRCGSYEALRSLLLYADDAVDMERQQLTFFETIKKYFYEAQTLFTALRGSFVGKSLEFVYLHKQMERKIAIVADLEKFFNESSNFTYVDVRRACFVGDDLAATQRLLDWKLTMRWANKFFSSIRSEWDKQLIHTYQLEWMDPRLLKFSPSVLAGVLKIIATAMDCAEQFDYLWHTRKLIQELGLTGSFDANATQELNQRLKPYYDNIFVVESKWRIVKTFCNSRNIELNERLVHELTNSDQEKLQALFDDRRKKLRTILEKHGMDTVENLANCMRNLPPSAEAGLEYLQLELCEMLVAVGYFGDNFQYLKHRMPMIQGRNYRNYLAHDSLSYNLLTDSWTEKIVINAYVIAYTELHLFGKREALKIEVTEMSYPKVQATHRWMEEQSQMIGAFQTEDLNQIVAAIKNGGEIRSVFCCSPNQKKAAPQFRNLNVLVDSCNVDPLMVQYLNTYFYGFAEVCGDPVHQLETALVMCNYQAAFDRTIGSGPARDTLIRNELFGWPELMLRVRKTDLFRHLVAAFNRQRILKALIEHGNERGVREILPFFEDFRDPTQLGPLRDALLYNLRSIAELLVPRTTGQHVAVELLLIIIHWNDMFPTVVLRSEMCSEKLQLLLKTAAQSRNYTASVFLLENELFKQHLPGAFSNSCIHAARMGETSLLQHLLEIHPATSQELAEIVHQAAVRKRWKCVSLLLDRDAPVDIEFPGKNSEESHTLFILVKFGLWRLIDRVRSVHCRMYGDNIKHPFSTAIGYGMMSGGMVRTLRRLGFDWLDSSMILHAAILRRDNAALANIWREIDVILQSNHLEIEDSRFAFAVKVFTTWQTIGFVEESTSLETSLICAIENKDKDMIKELLDRAKSMRHLEGIGILDSIVFKTSTSIVCFGKRDENRIGNVQKCCKDMIMRLKISAVLDMGWQEFMIDLGVPVQFYVLSANDEKIQPSPESADVNLRKSGSLLDSLNDFMTVSNELFAEASVIVANFKLSGGTSVYFCQVEDISCIYNILPAGAEIDLSATVNYRHLLGETPLHKCFPNDELATVKMLVEAGANPLLADRSGMAAIHVSLWNSKDYAVARYFVDVCQDRELRNEHGVSLVDLEDGNMKNRLIHIAVMTGRRDIVERLLQLKVDVSVINSIGFTPIQTALNVSLPNNIHMVKLLLDYDSSSINAIDSNGDTLLFRAIKYHSVEVLQEILRHDPDITLTRKDVRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT40</accession>
    <name>A0A084VT40_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525060">
        <property type="protein sequence ID" value="KFB41134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VT40"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008700-RA">
        <property type="protein sequence ID" value="ASIC008700-PA"/>
        <property type="gene ID" value="ASIC008700"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008700"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008700-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="17592" checksum="CF521167DC31E115" modified="2014-10-29" version="1">MYCNGRVRRKSDGGPVAVGCGQSENSNTFSRQSVRECHPGLPFVDARCARFYPGLLFAIVGTATPGRLSFPPPRRSASSRSRRREAPNSQRICNGFQVPVCFFLCEFLQGNDGQVWVKKFSTIHHKTPSPVKGQQHGGKSFSRTSNPFVGRKTIVSTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VT78</accession>
    <name>A0A084VT78_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ZHAS_00008733</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01016270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ATLV01016271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB41172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A084VT78"/>
    <dbReference type="STRING" id="74873.A0A084VT78"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008733-RA">
        <property type="protein sequence ID" value="ASIC008733-PA"/>
        <property type="gene ID" value="ASIC008733"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC008733"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009117"/>
    <dbReference type="OMA" id="CCYNCAS"/>
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    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13195">
        <property type="entry name" value="FERM_C_MYLIP_IDOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041790">
        <property type="entry name" value="MYLIP_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004282"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB41172.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008733-PA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="614" mass="67531" checksum="97B4356DE1CEFC01" modified="2014-10-29" version="1">MWCLVNLPNGTTSGVQCDPKRISQECLEKVCADLGIICETDYFGLIPVRDGDSVADVDECNAKQWINLRNPLHLYTNDRTHPIVFSLRVKFWVPAHLILQSSVRSLFYMQARQELFDGHLRPSSWTNAAYLAALLLQADGFRYDPAKVPSATVQPLEETPSTASQSSSAVESSASATSTPERRPQPQQLRRPSKRKCSEIECKRGSVSSQSSGGSSPTGWHLDDMGPGATSGGPTTASTTTTGVGTIATAGSVAELSNKAPKNIYHRYGALRPAFDDGEEEGEEEKKPENFHQLIAIEHEKLSRIKMSPTSAQYWLLEEVCSLVGYGEEIFEGVTIAEPSVVCKIGVSPHGLTIVKDDEKYSVPFTAVKAAKSIKRSFRLTYMDERHEETHVELKLPNHRTAASLYRAITEKHVFYSCETVRPVVTTQFIRDLKGTIVSMFNEDTELGKRYVFDIQRTCREVYDAARRTLHARGIEISNGAEEHGSESPAVALGRLEATLSVQKDDAGKLERMFDERIREAITCPICADGEIDTTFLPCGHMTACRTCAVQCDRCPLCRSNIESISKIFLPPLLQSRKGASANATISSRRQSDPSSTTSSTSIAAPKSVATLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU01</accession>
    <name>A0A084VU01_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP011038-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009042</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016607">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU01"/>
    <dbReference type="STRING" id="74873.A0A084VU01"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009042-RA">
        <property type="protein sequence ID" value="ASIC009042-PA"/>
        <property type="gene ID" value="ASIC009042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009042"/>
    <dbReference type="OMA" id="PQAYPTC"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009042-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="70" mass="7927" checksum="71ED2435BE0E1F08" modified="2014-10-29" version="1">MSNYPDIQDWMDPHSKLPPVILNDKLMTDAIIGTCMPIKTEHSYSLNSDGDSLPDTIPDSPHSLQNKMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU62</accession>
    <name>A0A084VU62_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AGAP002441-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00009107</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016645">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525099">
        <property type="protein sequence ID" value="KFB41506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU62"/>
    <dbReference type="STRING" id="74873.A0A084VU62"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009107-RA">
        <property type="protein sequence ID" value="ASIC009107-PA"/>
        <property type="gene ID" value="ASIC009107"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009107"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019578"/>
    <dbReference type="OMA" id="GNMVEWW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784092" evidence="10">
        <location>
            <begin position="20"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="556"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB41506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009107-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="762" mass="88194" checksum="1CEB8C6779EA84C4" modified="2014-10-29" version="1">MIVIIVIACLLHFPPDICHTPECLRSAAALKQSMDDTVNPCDDFYQYTCGNWEEEHPRPDTYTSFDWFSERQAKILRNIRQYLQANSTEFDPKPVVQARTMYRGCMNLTAMDRLGYGPVFRYLKQFYLPPYPSMLNVTEPPSETHAFDWVRSLAKIKQLLGMDVFIGLDVYPDPRHRDYNRLVLGTPETGSDLPFNTDILKHMRRHGRTRRKLTVSADDTDQEDDDREDDNISKDSASLVAYKRFMVGVMKILVNATDPTIKVDSFNASFEKAASIIVQFSDAIGKFNREAENASKSTNVEDRLNLQDIVYYTASELQNITDTHLAPKDPLPIWEQLLNGMFEGIPEAQLNLNEEMVLTSNADILYLKLLVEYLSVTPLAHVELYIWWTVVEELILHTTMEVRRLHYTYYQTLAISDGFSSRTLYCTGTVNRLLGMAVSYAISHENFTQHTKPRVQDMLRYIRTAFEGLVRDTTWMDWPTKQSTLRKSEAMRSLIGFPEWILDQQRLEQHYNGLKVNESTHLENMMEEVQRKNIIKLRRWRHKHELDWDTLPTNVNAFHTFQENAITIPIAILQYPFYHLGLEALNYGAIGTVLGHELTHGFDDSGRQFDENGNLKQWWTTKTIQEYVNRSMCFVNQYNRYYIPEADDYIDGLLTLGENIADNGGVREAFRAYQLYVKNSGKEALLPGFEGYTHEQLFFISYGNIWCESHTRAAAKAYLDDTHCPGKFRLKGVLTNSPEFSQTFGCKLGTEMNPSKDKCRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VU70</accession>
    <name>A0A084VU70_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AGAP003795-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00009117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01016668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525101">
        <property type="protein sequence ID" value="KFB41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VU70"/>
    <dbReference type="STRING" id="74873.A0A084VU70"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009117-RA">
        <property type="protein sequence ID" value="ASIC009117-PA"/>
        <property type="gene ID" value="ASIC009117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009117"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013304"/>
    <dbReference type="OMA" id="AEILMFV"/>
    <dbReference type="OrthoDB" id="262535at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009117-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="137" mass="15617" checksum="29783AFD3B10BF3F" modified="2014-10-29" version="1">MGNPSLTYEILLYLNSFYFGMFATCELGMLTLKAVNLKYPDHILLREACILVALCLVETIRIILGRRGSLSDHGWHVILSVFLTIPCGMGVGYLLFYQLHRLRLEYILCALMLSLQAAELFFAILFVFTLCRPPSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VUE3</accession>
    <name>A0A084VUE3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AGAP004841-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CARMIL family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01016728">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525103">
        <property type="protein sequence ID" value="KFB41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VUE3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009190-RA">
        <property type="protein sequence ID" value="ASIC009190-PA"/>
        <property type="gene ID" value="ASIC009190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009190"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014863"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018810"/>
    <dbReference type="OMA" id="KGCEERL"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000009">
        <property type="entry name" value="F-actin-uncapping protein LRRC16A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034596">
        <property type="entry name" value="Ribosomal_mL52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18699">
        <property type="entry name" value="MRPL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="11">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="10">
        <location>
            <begin position="775"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="944"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1260"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009190-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1376" mass="150929" checksum="A1424F6BBFC0155E" modified="2014-10-29" version="1">MSTRSQLTKDLNESVKTLLGRHTKILVKYMVKLEVKTDKTENRVLVFTPVRVYLLTAKVPTRIDCHFHYLDIQSIESRKPTHFTITTNDKSYSFSTIGDAGSFTSNADVILTDLSSAIKQIFPTVPLRYIIRKIDVNPIERTSIFSDELRPSDPRNVGPCGGFSMQYACMCDLHAVQYREEVAWDIDTIYLSHDARVLNLRDFDHLEQKDLMAIVAALEYNTFFRGLKATHTRLSTETLERVLQVLRRSLWLEELHLEALGLKSDFIHKLAVAVISNSAPALRSIDLSHNLIEDKGATHLAGPIAKMSKGFSKLALAHCGLSAKGVNQLAHSLSLNQNISSSLTYLDLSGNILKDDVNNLYNFLAQPNVIEHLDISRTDTTLESVFGALLRGCATHLLHLNVSHNNFGTKKGKEIPPSFKQFFTSSLSLKHLNIASCKLPLEALKHLLLGLACNESTAGLYLDLSGNSLGSQGAHVLESCIHGVRVLASLDISDNNMDYELAHVLTAIGKNPSIRALYMSKCFTGMKLKHIGTVMDSLVNLIQKEDFQLQELVLAENRLKTDLHNFINALGSNQHLQMLDITGNLMGDIGARLLAKALQINNKLKTIALDRNNVTLQGYADIVYALENNFSVRNMPFPLHDIAPCLKQHPERTDGLMKKMQELLFRNGNGFKRTHGQGFRLQHGFLLSSTHQVLDKLVAETQETMSSRQSSLDGSLSRLLEDAENCKQLLPKLQESVRCDPHPIEVRLGKMKTELHQSIRSYLQETMETMLRTGIEQCPKTLGSQVVLSELRKGCEERLTISEEFLQSCLVNSAGGEVMNRISEVEQSLASLISDRATDEVLEALTRYRKGLGIAEGPLGYSDDLLSLDGTKNNSSQSTEPIATFELRGLDLPKLGLDSPTATPQLQHKRRSIARKVRPQSVVGLGVENLSLANIPDVTEASIASNVSRSSSNSSAKKNRESPNPKEDECCDSITELPSQSLTLQHLVKGRPKRAKTRAPKKPVIADNVAAAGTVVNEGIESFFRPGSATPSTLTPLVSPTSEECSSLSFVDSPTLSRDDGGRFSNVTSGETTPILEERKPLKLDRSSPLLKGVNWTSRSRSSDNLEKVSPSVNRKSPLVKAATEVVETPRSGEARPLENNNGTMVVSGSSKSPSNESVRSHNVESSLGPRIGNGTGQKTPIISPKPRPWSVLGHESKAEFNESSVDSIDTDGDLVLISGQTPGGSIVGITPGAISTSVGSGGGGSILGITPVELERNSLMRSSTSSDPALAEPQRPTAGVDSVESGGSNSEAQKDTTSVKRIVAGKKITALFESNQKKRILQQREIAKQIVTLSKEMDFAVERHDRINAEHAKRKEDLVREKLKPKGHLLLKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVX0</accession>
    <name>A0A084VVX0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">G-protein coupled odorant receptor 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00009775</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01017329">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVX0"/>
    <dbReference type="STRING" id="74873.A0A084VVX0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009775-RA">
        <property type="protein sequence ID" value="ASIC009775-PA"/>
        <property type="gene ID" value="ASIC009775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009775"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002211"/>
    <dbReference type="OMA" id="ALTTDWY"/>
    <dbReference type="OrthoDB" id="7964808at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KFB42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009775-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="391" mass="45990" checksum="E04B8A50D87400F3" modified="2014-10-29" version="1">MEASNKFEQYMTFIRRLCRVLGFDVFNVEWKMNYRSYFSLFLCVQYLWWMIHSAIIAEGISEPLKTLAFLGFFFQSTLKIYYTLSNHEKFQANYNKLAQSIYEGHIEGTAEQKKVILRVITVVLALVKVTVVIYGFSLVMFSLYPAYMYFWEDTKVTIFPLHVPGINIYSLYGYSVTNMLHMLVAVYGLFGALASDTAFMMFVLHIVTYVELFRVECEKFESELLTSECRDRWHSKEYKALCRLSMLAIYQFHQDIISYMDSLKVCYYQTCMVQVATSSFSIMFNLFLALTTDWYATYSFLAVSLFQLLIFCVLGNVIQVMNDRLNQVILNLPWYLLPNGEQKRFLFMLYRSQLPADIDIRGFGPLNMETFTAIMQKIYSAFMMMYSFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVX3</accession>
    <name>A0A084VVX3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP002426-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00009784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017333">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525162">
        <property type="protein sequence ID" value="KFB42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVX3"/>
    <dbReference type="STRING" id="74873.A0A084VVX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009784-RA">
        <property type="protein sequence ID" value="ASIC009784-PA"/>
        <property type="gene ID" value="ASIC009784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009784"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003584"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="203" mass="22648" checksum="F2672AAF7D3BE3DF" modified="2014-10-29" version="1">MLDALGVIVSGRLVQTDFQQISDTHFLINIPDADNVNHVVVFLTGTTPFPQGMAGGVYFSWPDPNAPPNWQLLGYISNSKPSAIFKISQLKKLDEIANQSGSMMTNNVFGSNLPISHIAQIGVSIEPESSLIQQTPSTTSSSTYYQFGQKILENFFNFVSSFSVTQSQMTPTPNETFVPLSTVQTWYTNFQRRLQQNPNFWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWA1</accession>
    <name>A0A084VWA1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00009941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWA1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009941-RA">
        <property type="protein sequence ID" value="ASIC009941-PA"/>
        <property type="gene ID" value="ASIC009941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009941"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015436"/>
    <dbReference type="OMA" id="CYSPPPK"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009941-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="491" mass="50935" checksum="4ABFB6E458FFE24C" modified="2014-10-29" version="1">MDVDSPNALKRCSSAPQINNLVSSTATVGVQPMDEGQSQPGPSSSNRTSGSSLQLNRALFTSGLPEPQPGSGMLNTSSSLQGSPNDGSRESLPTSFSNIFTPRVRRFSASFSPLAVISNGSASPSRNGSGTPGPRLTPRISQLRQEECADVTNTREVNHEREIHSAMQMSQSYEDLTLVAENWSFAASASKMMNDDLQNPLHVALPTIGSTCCSSPSPTSRGGIGLQYPTTSPSPTRKFVTRRSMSPCPLRPSPLSSSVKRKFDLDDNYGNCYSPPPKKIFTSERGSSPVCQTPSPSPICPSPDSSTTSFENGSNNNNGNGNPPPSGLFPLATASGSGSGRVTPKFFLTKLSGAPSPGPPTLCPGNPFGVGIVGAGSTMHYGGGGSASSSTCTTPTGGVPTNPMGSLMGETVGTGRNVAMMMDCGVSSSSSSSGSDCRDTAMEIGHAGGGGVVEERTEQERDIDETPLKADSSTVIPTISVSKREWALPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWB6</accession>
    <name>A0A084VWB6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FR47 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009939</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525174">
        <property type="protein sequence ID" value="KFB42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWB6"/>
    <dbReference type="STRING" id="74873.A0A084VWB6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009939-RA">
        <property type="protein sequence ID" value="ASIC009939-PA"/>
        <property type="gene ID" value="ASIC009939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009939"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003359"/>
    <dbReference type="OMA" id="MHPRDEL"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF10">
        <property type="entry name" value="GH05617P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009939-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="336" mass="38404" checksum="5D0214849B473252" modified="2014-10-29" version="1">MEDRLVKIPTGDWMEWRDLYKTDWPRHEVSYNLIQNYIDWLEQGAELKEFTALSLNGEWAKDGTYIDRHEMFIYTLDGRLESLRRALLLLDWTRSYLINMGLYRSLLMDIYQLFNLDILFDMHTYIYYLPHEDASKLEVDVPDGFKFGPLKPDDAIFINDEWPHKYPGSELFIERLITRNLNLALFDGDGNLMAWCMRVQNGAMAMLGVAQTRRGYGSMMALGFARKLGELGLNVYASVIHTNEPSRKMFDKLCPTAARIATQAVALADIGHKVSIDTIANAGAIVAVPIRRVGTDLGQHLGLPTVVAPAPRSRPRTELRFVSTHQSQVDAWECLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWL9</accession>
    <name>A0A084VWL9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001788-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00010054</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525181">
        <property type="protein sequence ID" value="KFB42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWL9"/>
    <dbReference type="STRING" id="74873.A0A084VWL9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010054-RA">
        <property type="protein sequence ID" value="ASIC010054-PA"/>
        <property type="gene ID" value="ASIC010054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010054"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021577"/>
    <dbReference type="OMA" id="HHGVRDP"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010054-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="304" mass="35737" checksum="3BF2A94759DC4161" modified="2014-10-29" version="1">MSRFGPKHRKIPVPKRHGVRDPLKRLAEREAAIKDQINNPPKERDVQEVSHRFKRFMQLKEQANRPRPQNESRGRAQPTIHIGKTAVKKQPKESEESFLNRATMMQEDRTVEEDFGVKYGVEVERNEETGAIKIRKRKGIEVDEMLNKRMKQIERNGGKPDKRAKKAKKLTMTEKKALKLQKQEELKRQEEDLLLKEYQYDYVPFGDVVKEPPSLNTLPRRANKPESVARPASKRLLLHSLMEPKPEEEEQTPMKKRTSKKAPPTKVDLKGKRKKLPMATRMNIEREQQSVIEMYRKLKKKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXD5</accession>
    <name>A0A084VXD5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ZHAS_00010356</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017988">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525205">
        <property type="protein sequence ID" value="KFB42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXD5"/>
    <dbReference type="STRING" id="74873.A0A084VXD5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010356-RA">
        <property type="protein sequence ID" value="ASIC010356-PA"/>
        <property type="gene ID" value="ASIC010356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010356"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000424"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783912" description="Large ribosomal subunit protein uL1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KFB42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010356-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="229" mass="25893" checksum="13261BC23F850294" modified="2014-10-29" version="1">MLANTILLYLFFSSSKVSRDILYECVTEVLKGAKKNHRRFHETVELQIGLKNYDPQKDKRFSGTVKLKYIPRPKMQVCVLGDQQHCDEAKANDIPYMDAEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRLLGPGLNKAGKFPGLLGHGESMVGKIDEVKATIKFQMKKVLCLSVAVGHVKMSTDELAQNIHLSVNFLVSLLKKHWQNVRSLHIKSSMGAAQRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXI5</accession>
    <name>A0A084VXI5_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00010414</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01018074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXI5"/>
    <dbReference type="STRING" id="74873.A0A084VXI5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010414-RA">
        <property type="protein sequence ID" value="ASIC010414-PA"/>
        <property type="gene ID" value="ASIC010414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010414"/>
    <dbReference type="OMA" id="YPLSLCC"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010414-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="108" mass="12493" checksum="AE79AD0B86E0109C" modified="2014-10-29" version="1">MKCRSVGGWYVVAAVVTLLLAFVGADEHNHMYEDHEEIVLWMNTVGPYHNRQETYAYFSLPFCVGAKQSINHYHETMSEALQGVELEFSGYEIDFKVHKRILQKQIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ64</accession>
    <name>A0A084VZ64_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Translocator protein 2 isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011039</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ64"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011039-RA">
        <property type="protein sequence ID" value="ASIC011039-PA"/>
        <property type="gene ID" value="ASIC011039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011039"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011039-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8341" checksum="97BB686CE125843D" modified="2014-10-29" version="1">MRARPGGTARRNDDAKGTRAAKRSSSCAKAAREGAIAIAISETETRHRTTKRLGSSEAPRVSDFGQKAPLERGWGMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W000</accession>
    <name>A0A084W000_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP002815-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00011356</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019061">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W000"/>
    <dbReference type="STRING" id="74873.A0A084W000"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011356-RA">
        <property type="protein sequence ID" value="ASIC011356-PA"/>
        <property type="gene ID" value="ASIC011356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011356"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010638"/>
    <dbReference type="OMA" id="CIENAPG"/>
    <dbReference type="OrthoDB" id="6437225at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000082">
        <property type="entry name" value="Plasma kallikrein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040479">
        <property type="entry name" value="CLIP_SPH_mas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF140">
        <property type="entry name" value="BCDNA.GH08420-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18398">
        <property type="entry name" value="CLIP_SPH_mas"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784307" evidence="3">
        <location>
            <begin position="19"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="633"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
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        </location>
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            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB43544.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011356-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="877" mass="94448" checksum="5688C549AC113E6D" modified="2014-10-29" version="1">MILKTTIVLLLLAASGSCQDDSLAGSFLSGLLDSITSTEDAKGCPGVCVHTLATLICYEVLDDIPCPSPSMKCCVESSTAAANISTTPRPRPTTTTPRPTTTTPKPTTEAKIKEKDNKNNSSCPGVCVADRIAEYCEAYLTTAGLCKSGSKCCVSRDIYPDNAPDELYIPTAHFDSKTNKTTTPKPYAKTTERPHTTEEPIKSKTNPTPKPTPKPTKPVAPSKLKTTASTLANNGQGPVFKECEGECVNGLFALFCDDLDSEAFCPNEGSCCITGVAEDNKQQLVTTTRRPATPPPLPRCPGFCLLNIMAAFCERPSVLIPNTANCKRGSVCCDNTRAPPPRPPQQKRPPPPTTTTTPAPTTTAIPDPREECPGSCIVSLLSFTCFRNAEMTDLFKCKKSGTQCCAPKSKIQEVQAAAASKTKYNDTYPPQALPPPPQMMPQQPAVPGIMGQQPYPMVGQGSMPPQPPQQQAPLPPHQQGYGPPAPNPYPGPISNNIYEVAPTQPAPYAQSPVYEPPTTTPRPQVYSKYVCGVKGTSRAAKSYLTREVLLLERDHELHEQTTLSRQARHIDVDSIYRSKSSERLVLGSSIVPIPIIYHDHNDTVPEDLLRHPSVKENATVVAKYWSNHRKGRVVGGEDGENGEWCWQVALINSLNQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDYDLTRKYGSPGAQTLRVATTYIHHNHNSQTLDNDIALLKLHGQAELRDGVCLVCLPARGVSHAAGKRCTVTGYGYMGEAGPIPLRVREAEIPIVSDAECIRKVNAVTEKIFILPASSFCAGGEEGNDACQGDGGGPLVCQDDGFYELAGLVSWGFGCGRVDVPGVYVKVSSFIGWINQIISVNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W030</accession>
    <name>A0A084W030_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP001225-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019081">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W030"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011436-RA">
        <property type="protein sequence ID" value="ASIC011436-PA"/>
        <property type="gene ID" value="ASIC011436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011436"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021303"/>
    <dbReference type="OMA" id="MKSDRCV"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
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        <location>
            <begin position="1076"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011436-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117319" checksum="DC45246FB7DD22B0" modified="2014-10-29" version="1">MANDSRHIITTPSSGTSVVPRLRPKPAQPTSTTPSMGLTLGTIPLNPSPKNVISPIPAATMESDKFVANFNDKFLGTSMPRFSPTSMEGELASFKLTTTSSAVSPATLLSPFEQESMSSSTTVSVRPRPTALAHSQQQILSNSNSEKSLVSPLSSSFTWNPFGDPSPFSPISTLTEDQLFGAEFDKLRLEGSQNSIVTSPEEMKSDRSISYWGGPQRKPLSQALSTGMIASSGGVQNGKELPMLEEDPFGSAPFTLPKRFKQKSSSSKLASKLSDRWRHAVGSGQAGKESLIDDTPTENGRNDIDKRPGSSTRTEILGLEKSGLIGGGQKNLMLDDLINSGDKASPSFIKLPLDDRNKYEKLNSNGVTSDDSDSEFYHETMGTAVGFGSGPDNIAIPGSVGGGIGGLKKHSFKHFVESNIPEKLQAVYHKVDKSQIKHVHIVKKLRNKVVAHGGKESVPAGIGSTKVAKGHRKGKRNGGQQEDINAPEGANASDDDSIGSASDLRANDDFPESEEIDPKAPPNSSVRKRASFNRASFGGEGSVDDCFSESIKTCGSSAYHAECESVTTNEDNTSRIVTRVRVKKRERLDSKHSVIDEDDSAEEDMIQGEKPLLLDDELDYESAVENNTSGEEVLMDPFTPEDEAVKNKPHLCLEDDSEGDAVLDPFAMAPFRKPFVNKRNNVVKFMPGVHSIPEHHPTSSGVGATQPSSDFMTSTPIKKPAPELASQSSQCTDIFEMPEERIVPLPGPLETPLVREKSPNIRQYSFGSEPLLATPSMASASSPAAASDPNVTITLPPIQQRHTPLSNAATSQPHKTSFSVTTTHDSLISNRLPFDVDAVTLMHIIPRNTCPAISGTIPVVSTPAASSPSSSLAVVTSSISSVSQQHYSPHVLAGHQELSARRNYINFSQIPSRSMACITPDNNYVNFCPNEEDDDVRKLKSDEYDDNSSDTMAKVSSKGFLTKKQKVKYNHLNEKSNSSGGCPNHGKDENVSSTLGQKVKANVSGYRKVVSEVTSNGKSKKEEPFSKQLKGCSKSSSKTMGFSNMSFEDFPSDELGDEAGSADGTRLTYGNRREXXXXXXXRRSNPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0W0</accession>
    <name>A0A084W0W0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005987-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00011704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0W0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011704-RA">
        <property type="protein sequence ID" value="ASIC011704-PA"/>
        <property type="gene ID" value="ASIC011704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011704"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011004"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784329" evidence="2">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011704-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="104" mass="11962" checksum="A744D52560481F2F" modified="2014-10-29" version="1">MKTLVPVALWCLLLVRPGTGAPFTLRDLVEEGIAVPESKMIDFENLTESEREQFMRENVNITALKIQQRVLREQQNKNRTSGQPPITQRTLDQNISDLVKTRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2H1</accession>
    <name>A0A084W2H1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00012197</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525275">
        <property type="protein sequence ID" value="KFB44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2H1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012197-RA">
        <property type="protein sequence ID" value="ASIC012197-PA"/>
        <property type="gene ID" value="ASIC012197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012197"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012197-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="49" mass="5647" checksum="2D87357A408B6234" modified="2014-10-29" version="1">MPDTPTECLSFRAEEILINNGELNSFATTEEPDRYRDHFKSSLEARVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W2U7</accession>
    <name>A0A084W2U7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="5 19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ZHAS_00012479</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 19"/>
    <dbReference type="EMBL" id="ATLV01019698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525278">
        <property type="protein sequence ID" value="KFB44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W2U7"/>
    <dbReference type="STRING" id="74873.A0A084W2U7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012479-RA">
        <property type="protein sequence ID" value="ASIC012479-PA"/>
        <property type="gene ID" value="ASIC012479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012479"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017031"/>
    <dbReference type="OMA" id="ACINHSC"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KFB44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012479-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="235" mass="27002" checksum="2F8C85DE771A83AC" modified="2014-10-29" version="1">MTYSNVHRAFLQACSNHGTISSQQAYEILIGIYARYGETEIIPKEDVVAEVVSEINTRIYPYDQKIAYMHYDPTDTDFYVFVSLMESPIDLQQNNYTVPELHYFRALLRELTLSEDHQLPSIACLNLTNESGSEGNKPLSKARAEQLLSEWEGLGYFLVLQDKCYFGPKAIVEFDKYLNTNYADVITRCCLCNVTIFYGVRCASCPQILHKDCLKKYLRRLTNCPSCKKLWSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3E2</accession>
    <name>A0A084W3E2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP004402-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00012654</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01019939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525286">
        <property type="protein sequence ID" value="KFB44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3E2"/>
    <dbReference type="STRING" id="74873.A0A084W3E2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012654-RA">
        <property type="protein sequence ID" value="ASIC012654-PA"/>
        <property type="gene ID" value="ASIC012654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012654"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004444"/>
    <dbReference type="OMA" id="WLHVGFF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 17, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012654-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="541" mass="60042" checksum="144D80F77BBD0A5D" modified="2014-10-29" version="1">MDEKEVSFLPKPKMPKVGCFRAICDRIPARLVLYFLSWSGFLVSFVMRNDINFALVAMVQDPSSNSTGSDHCVSPSVVVSGTQDNFTTLMNMTLDDGEGIIDDGLDLLAVGNDEIKFNWDSTVQAVIKSSFYWCYVLSQVVGGVATQYFGTKSVFGWSQFLTAACSLLIPAAADVHYGAVIFLRSVQGFASGLTWPAMYAIVGYWIPPVERSRFMSSFQGFSIGIGLTYPLCGFIIAHFGWRQVFYTTGTIGMVWCVFWYLLAYNTPQEHPRITAEELEYIELNVSEDIKNGQGMRVPWRRIFTSMPVWAIGLTTFGRIWVHYTFIMSGPEYMQKIFCFDIQQNGLLSGAPFLCSYLSSVLFCYVADLLMDHKTLSLTNVRKLFTALSQIVPGVLVLLVGYLGYQIVTVLVLWFVAVTFITASYAGAMANIVDIAPNLAGPVLAFAQTIHMTASFLQPLVTGFMVTDSQNLTQWLHVFGVSSVVAISTYVIYQVFGTADIQSWNYPVADPEVTSSDDSAVIANQPMIKVEPGLKFDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4A5</accession>
    <name>A0A084W4A5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGAP005681-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00012992</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4A5"/>
    <dbReference type="STRING" id="74873.A0A084W4A5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012992-RA">
        <property type="protein sequence ID" value="ASIC012992-PA"/>
        <property type="gene ID" value="ASIC012992"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012992"/>
    <dbReference type="OMA" id="CKCSVYL"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000258">
        <property type="entry name" value="G-protein coupled receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF170">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012992-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="322" mass="36537" checksum="3AE4E2D73EC3882E" modified="2014-10-29" version="1">MHGLSHLQTGSTLEALTQATIIFILAVAIVISNLIVVATYLNFKGPHEVINYYLLSLAVADLLCGLFIVSLSVYPAFYGDWVYSNVLCRMVGYLEVTLWSISVYTFMWISVDRYLAVRKPLRYETIQTKTRCQCWMAFTWISAAMLCSPPLLGYNRADYNKVTHICMLEWGTIEAYSATLAILVLGPSVISIVYNYGYIFTMMRKVRSGAPIHDKEYATALAENLANPSHCMSFALVFSFWISWTPFIGLRIYELVTGDTIDNPLLHFAAVWIGILNSFWKIIIMTTMSQQFRLLVRLLFLTICCKTKGRQQAELIGLETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4K2</accession>
    <name>A0A084W4K2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008227-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4K2"/>
    <dbReference type="STRING" id="74873.A0A084W4K2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013101-RA">
        <property type="protein sequence ID" value="ASIC013101-PA"/>
        <property type="gene ID" value="ASIC013101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013101"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS014523"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000113">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000324">
        <property type="entry name" value="Putative Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000006">
        <property type="entry name" value="Trehalose 6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000150">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013101-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="816" mass="92119" checksum="0C36B936B2803296" modified="2014-10-29" version="1">MSANCEITITSPQEAHSKGSLIVVSNRLPFVLKRDPKTGKLSRHASAGGLVTAVAPVVIKGKGLWVGWSGITLDDENEQIPESDPSDVTPTAGLLSEQVVSVNVEPKLFDSYYNGCCNGTFWPLFHSMPGRATFCADHWKSYYTVNKEFAARTIEALERCLQQNTHQGVPIIWIHDYHLMLAANWIREAADERNLPYQMAFFLHIPFPPWDIFRLYPWSDEILQGVLACDMIGFHIRDYCLNFVDCCQRNLGCRVDRKNLLVEHGGRSVRVRPLPIGIPFERFVELARTARKVINTNQKIILGVDRLDYTKGLVHRLKAFEVLLEKHPEHRENVSLLQISVPSRTDVKEYQELKEEMDQLVGRINGRFTTANWSPIRYIYGCVGQEELAAFYRDASVCLVTPLRDGMNLVAKEFVACQINEPPGVLIVSPFAGAGETMHEALLCNPYELDAAAEVIHRALTMPEDERTLRMSRMRRREMQNDVNSWMRQFLKAMGSLEEDDIGTTTMQPVSVDDFDDYLLNYIGYNHKLALLLDYDGTLAPIAPHPDLATLPPETKNVLQRLSNHSDVYVAIISGRNVENVKQMVGIEGITYAGNHGLEILHPDGSKFVHPMPIEYEDKVSGLLKSLQDSVCGDGAWVENKGPLLTYHYRETPAELRPAMVEKARQLIIQFGFRAAEAHCAIEAKPPVQWNKGRASIYILRTAFGVDWSERIKIIYAGDDMTDEDAMMALKGMAATFRVTNSQIIKTSAERRLPSTDSVLTMLKWVERHFMRRKPRANSLTYRGKKKDCVKMQMAFDLVPNSSGASSPVCSSDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5A0</accession>
    <name>A0A084W5A0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013390</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525303">
        <property type="protein sequence ID" value="KFB45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5A0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013390-RA">
        <property type="protein sequence ID" value="ASIC013390-PA"/>
        <property type="gene ID" value="ASIC013390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013390"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013390-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8732" checksum="92427EB31568190E" modified="2014-10-29" version="1">MPDAQGTRLSRNAEYVTKSFQSLSVKESCYQKPNKHPPPHLSGRLTSVMMWVNRYASGCNSLPQQQRLAPEDNPSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5I0</accession>
    <name>A0A084W5I0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AGAP010228-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00013453</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA. Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA. Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01020648">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5I0"/>
    <dbReference type="STRING" id="74873.A0A084W5I0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013453-RA">
        <property type="protein sequence ID" value="ASIC013453-PA"/>
        <property type="gene ID" value="ASIC013453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013453"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003874"/>
    <dbReference type="OMA" id="IYYDPML"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="103"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="572"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB45474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013453-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="652" mass="71697" checksum="333AF7DB8305BB89" modified="2014-10-29" version="1">MRTANRLGIRTVAVFSDADANSLHVKMANEAYNIGPPASQQSYLRGDHIVEVAKKAGCQAIHPGYGFLSENVEFAELCQQEDVIFIGPPASAIRDMGIKSTSKYIMSAAGVPIINGYHGENQSDEHLMEEAQKIGFPLMIKAVRGGGGKGMRIAMTEADFIPMLQSARTESEKAFGDTVMLLERYVRSPRHVEVQVFADHHGNAVYLYERDCSVQRRHQKIIEEAPAPGLSEELRVQLGEAAVRAAKAVNYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIKVASGEPLPMKQDHIRKQGHAFEARIYAEDPSGGFLPGAGPLDYFSTPELSATTRVETGVRQGDEVSIHYDPMIAKLVVWGKNRGSSLQLLIEQLTNFQIAGLQTNINFLIDLAKHNHFQSADVHTGFIDQHMATLFPKKIVPPVKVAQMALAYIINDRVQSSAVLGSKPLGPFATEHNFRSNYALIRSIKMKVGQETYMVDVKTLGDAYSVRLNGGDWMKISSVRRKPHVNRFILETNIEGHVSCYNAVIIDENVTLFDENGMIEGEIAQPRFLATESSMGNLDVSSVTAPMPGVLDKVFVKPGDTVKAGVPVAVLIAMKMEHVLKATKDGVVKSIPNSEGSNVRKGAVLISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5S9</accession>
    <name>A0A084W5S9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013560</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525305">
        <property type="protein sequence ID" value="KFB45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5S9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013560-RA">
        <property type="protein sequence ID" value="ASIC013560-PA"/>
        <property type="gene ID" value="ASIC013560"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013560"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013560-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="160" mass="17887" checksum="A56A89E9CAC78E54" modified="2014-10-29" version="1">MLRRPDKRLRPVIERIAECINFCIVPSCIPGDSKDRDRGDIDASSERSRAQTKANASKAIWLVRYSFNRAASRTRPTQWSLQTPLLWGVMGVSFSDAVIDGPLGRRPRAIILSGPFGVRHRALSKGARGTSPGSGVRLHESTTEWTMQLPFAAVKRSREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6M8</accession>
    <name>A0A084W6M8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ZHAS_00013832</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01020880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6M8"/>
    <dbReference type="STRING" id="74873.A0A084W6M8"/>
    <dbReference type="ESTHER" id="anoga-Q7PVF9">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC013832-RA">
        <property type="protein sequence ID" value="ASIC013832-PA"/>
        <property type="gene ID" value="ASIC013832"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013832"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019069"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KFB45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013832-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="278" mass="31008" checksum="430DD3F8FC6AE283" modified="2014-10-29" version="1">MPVPLAFTRYENNSTTDDAPPVLVLHGLFGSKSNWNSLAKAFHKNTKPIRKIYAIDARNHGDSPHTGEHSYEHMVEDLVAVYKTLGIQQASIIGHSMGGRAMMLLALKYPHLVEKAIIVDISPSPGLGTSNTNIPLFLQSMKMIQISPDQTIHQARKIADDQLSRIIAEKPLRDFLITNLVKNDEDSGKFHWRINLESLERNFHTGVAQFPTLSGVKFDGPTLFIAGGRSDYVKPKDVPLIKTLFPNSDIKYVKDAGHWVHSEKSAEFSKLVLDFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6X3</accession>
    <name>A0A084W6X3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013932</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525311">
        <property type="protein sequence ID" value="KFB45967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6X3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013932-RA">
        <property type="protein sequence ID" value="ASIC013932-PA"/>
        <property type="gene ID" value="ASIC013932"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013932"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013932-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="256" mass="28489" checksum="4E843CFC2DE24D96" modified="2014-10-29" version="1">MRDRALVSVLAAFSGRKGSPPCAAKPKRSIFRRRQVSSRGPAFSRREGLTRSQTAPVLGPDEFLTNVRSIPPVRFAHRFPPFFRASTLDGDGSNLFMCEEIFNGHRKPNPGTRADVPFRAKRRGRVTMTTAHLVSSRWFLRKKADSVYSNVQPGDADRHDFAGMDIASSSPYIGVHPSVKTCSWRNVGVCNKVRFQLVFPFGVAKEIPSRETRAFCSTVLMAVRFVGRVGNETFSSIKVIRSPFVVGAGRPRVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W734</accession>
    <name>A0A084W734_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W734"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013999-RA">
        <property type="protein sequence ID" value="ASIC013999-PA"/>
        <property type="gene ID" value="ASIC013999"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013999"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784367" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013999-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6562" checksum="3C20076E6F364470" modified="2014-10-29" version="1">MHGEIGTEPGRFRTAKILICCAIISRTLAGNGFDRVTRTTTTTTTTTTTTRDGEDATVMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7T4</accession>
    <name>A0A084W7T4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP004606-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525316">
        <property type="protein sequence ID" value="KFB46278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7T4"/>
    <dbReference type="STRING" id="74873.A0A084W7T4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014264-RA">
        <property type="protein sequence ID" value="ASIC014264-PA"/>
        <property type="gene ID" value="ASIC014264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014264"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002820"/>
    <dbReference type="OMA" id="IIGDRRN"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="3">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014264-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="118" mass="13453" checksum="5A28FC354DEE268D" modified="2014-10-29" version="1">MGEKEPVNGVDDATDKKQKKSTKHDSGAADLERVTDYAEEKEITSHNLYSNAANLFEDKRSKENEEKLAKERELQKVQVKKEDIELIIREMEITRSKAEQTLRVHRGDVVAALEALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8H6</accession>
    <name>A0A084W8H6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525318">
        <property type="protein sequence ID" value="KFB46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8H6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014512-RA">
        <property type="protein sequence ID" value="ASIC014512-PA"/>
        <property type="gene ID" value="ASIC014512"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014512"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014512-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="69" mass="6980" checksum="859C081DC529F082" modified="2014-10-29" version="1">MRPSGAKGCPGTEEMNDNWPSTGLAAIARLGGWLGKSHGAGVELPAASCWDGALQGGQLIGLEPPPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8J7</accession>
    <name>A0A084W8J7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00014634</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01021481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8J7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014634-RA">
        <property type="protein sequence ID" value="ASIC014634-PA"/>
        <property type="gene ID" value="ASIC014634"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014634"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017265"/>
    <dbReference type="OMA" id="HYEATHT"/>
    <dbReference type="OrthoDB" id="7737865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014634-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59333" checksum="0387D336529A7311" modified="2014-10-29" version="1">MEDTSVDLFQRGIDRLCDPTYFAEVLVLTNDEMDFSGVDSLLKSRLGTFRPVSLRSYTLLSTPSEKACVVGFFNSMEIAQVAEVHFEMMALLIAVLPEDLVEPMSNFAEMMFSFAIHFFAYNRSTLIGSWLVDRGGVRYNSLEDFGPGGATGWDLRGQSLVFLKVDPNYNPTYEEEMGQTIAKRHNGTFISTINYMQSADFMFSPIYMGVKCTFVLLPEMFRMCYIVPRSRRKSIFAILIDPFDYISWGVLALTIVIVSCLLAALGETYRRYGIALTSLELLMMSINGPTHRYGGRFEVRIVGIFIMMNIVLVSCYQSLVISFMSAGRYEPELDTLVQINDTCQFFYDPQRDGILGYKFRHIFHTFEMLESEETRWTNKVCEMVSCFKKASSDGNDVGELFRYSKVQTGSTVMMNAIFLHSPMRALIQRYSFAFSESRLHYFPQLKIGKEIRGRNGHDTLHDLKVEPMSPSELLIVWIVFLIGCLAGGIIFLLEMIVAFLPKKVRILKRKRNNTQDLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8W3</accession>
    <name>A0A084W8W3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014564</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8W3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014564-RA">
        <property type="protein sequence ID" value="ASIC014564-PA"/>
        <property type="gene ID" value="ASIC014564"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014564"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014564-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12773" checksum="8973E0C7BEEA8853" modified="2014-10-29" version="1">MPRNVQRRDGWAEGAKKGAPKRWIISPIVRHTLGSAPVVDQQASEIDDRFDDHKLAWRPVKMELLFRNEATQNETKPRPMLRRELTPDRLLFGTHSGKWVWPIFCLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8W4</accession>
    <name>A0A084W8W4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Putative sporulation integral membrane protein YlbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014565</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8W4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014565-RA">
        <property type="protein sequence ID" value="ASIC014565-PA"/>
        <property type="gene ID" value="ASIC014565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014565"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014565-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="188" mass="20955" checksum="633780AF7543041F" modified="2014-10-29" version="1">MQTNLSRHNRCYALLSACSNDDVEDEALFISGVDKRVAQSRQHGDDAPKEIGFRYIVSQSNSEGDSEIAVAGSPAMSKFGPNVLHKTCDLPFPAIECSSGLWVEVNGFQITHWYLPRRSSLPVVRRTLSPASQRLQEAGSRRRTLGGEQSERWISLIGDHSSITDDGRWTIRTMFPHCADCPAFMVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W935</accession>
    <name>A0A084W935_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Nuclear receptor binding set domain containing protein 1, nsd, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014730</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W935"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014730-RA">
        <property type="protein sequence ID" value="ASIC014730-PA"/>
        <property type="gene ID" value="ASIC014730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014730"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014730-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15270" checksum="93EDFA728DDA9ED5" modified="2014-10-29" version="1">MLAGANCGWCGVHFAGLNPQGERSGVKLETPTLNEEDTSRGAKWMLKGVLMAGHGTVQVALNKQQQTTDSGITTPNIKAFGDRPRPVNVRRLYPSHPGSFIIMSGTHSVWNPCPVHGVPVSQTLTFREVPWYQSKLYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAG5</accession>
    <name>A0A084WAG5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">80 kD MCM3-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015232</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525329">
        <property type="protein sequence ID" value="KFB47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAG5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015232-RA">
        <property type="protein sequence ID" value="ASIC015232-PA"/>
        <property type="gene ID" value="ASIC015232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015232"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015232-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6172" checksum="B7926197EC303C65" modified="2014-10-29" version="1">MRGSPFACNRKEKPEPPSAGSQTGDGKDSGKQFAHPNVRIQASIANWYRAVQWEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WC61</accession>
    <name>A0A084WC61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Alk-exo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00015760</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01022573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525333">
        <property type="protein sequence ID" value="KFB47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WC61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015760-RA">
        <property type="protein sequence ID" value="ASIC015760-PA"/>
        <property type="gene ID" value="ASIC015760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015760"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759981" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015760-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="60" mass="6601" checksum="CBAD1DA60DBDBA58" modified="2014-10-29" version="1">MTPKLRGAVGALVLVLLLHCIAPGSGYQHLKSGFRATEQFEYECMPVEAYFCGRWGINLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE26</accession>
    <name>A0A084WE26_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016455</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525340">
        <property type="protein sequence ID" value="KFB48470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE26"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016455-RA">
        <property type="protein sequence ID" value="ASIC016455-PA"/>
        <property type="gene ID" value="ASIC016455"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016455"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016455-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="122" mass="13795" checksum="9204FB1166A482F9" modified="2014-10-29" version="1">MGSLRWNNFSVCKTAKKGFYGPDRTETPGIQCRGTPTSSVMSNIRHGMHMHLCVPQKPPNSVARKCLTRRSVLVRNVYARRQDMSDRYQTLSTLSLIVWEKLQQAASTGSLWNPEAYGKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WE63</accession>
    <name>A0A084WE63_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016711</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WE63"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016711-RA">
        <property type="protein sequence ID" value="ASIC016711-PA"/>
        <property type="gene ID" value="ASIC016711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016711"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016711-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="17449" checksum="5F475564E61C7FAC" modified="2014-10-29" version="1">MNHGRSGALVRFAGRSQRTLAVASVTPAPTCEAAKQSVPGPPSPTAKRAHALPVPLALVAAGCCCGVRWCMREKVPLPYYPHPLPAAPMELGGEVFTMGLALKLQKVPPGSTVDFSDFRRENSNTAAFVSDWDSYQVSSPGCAWGAQAGAKAKNRCISPRGGFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEC1</accession>
    <name>A0A084WEC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016878</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016878-RA">
        <property type="protein sequence ID" value="ASIC016878-PA"/>
        <property type="gene ID" value="ASIC016878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016878"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016878-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="56" mass="6424" checksum="FD01B854FCED8A00" modified="2014-10-29" version="1">MFVKVSPVVPICVSHPGHVFQRRSGAFGSRMEKRDFYYYDFCPEPEPQLMAGSWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEV0</accession>
    <name>A0A084WEV0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012000-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016749</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEV0"/>
    <dbReference type="STRING" id="74873.A0A084WEV0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016749-RA">
        <property type="protein sequence ID" value="ASIC016749-PA"/>
        <property type="gene ID" value="ASIC016749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016749"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002703"/>
    <dbReference type="OMA" id="RNNTSCK"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="121"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016749-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="305" mass="35724" checksum="6526368156DE2BB1" modified="2014-10-29" version="1">MPTVMEAIVHAMIDFRREILDNLQLSLEFHTEQMEEIKHYTEHMMNEQEKRIKSEFREEITRRFDQQQISSLHQNQESKTQTTAQFNELRESIIMLREDTNTLCNETSQKITNIERALGEISNELVPRSCDRVKSNATGGFYINPYGHLDQQFMVLCNFDSNFNLGGGWTVFQRRIDGSVNFYRNWTMYKNGFGNINGEHWLGLEKLHVMTRSGRHELLVLLEDFEGKSIFALYDEFNIGSEEEKYKLTVGKYSGTAGDSLAYHSGMKFSTFDQDNDVDDDKNVAEYDKGAWWFGKAWKSYVYHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEV3</accession>
    <name>A0A084WEV3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016752</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEV3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016752-RA">
        <property type="protein sequence ID" value="ASIC016752-PA"/>
        <property type="gene ID" value="ASIC016752"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016752"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016752-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="10234" checksum="152B76D0B94A463C" modified="2014-10-29" version="1">MGRPCDKRTLGSDRFHRHVRPNPTNTHALTFKRGDIVSKFDGGGGGEIWQQRTDCQQGKTFTDVAQSGQAFGEGVMERLFLTIVTRNVPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEY7</accession>
    <name>A0A084WEY7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">BTB/POZ domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00016791</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEY7"/>
    <dbReference type="STRING" id="74873.A0A084WEY7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016791-RA">
        <property type="protein sequence ID" value="ASIC016791-PA"/>
        <property type="gene ID" value="ASIC016791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016791"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS012339"/>
    <dbReference type="OMA" id="TDITWET"/>
    <dbReference type="OrthoDB" id="7492888at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF9">
        <property type="entry name" value="LUTE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="354"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016791-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="699" mass="81724" checksum="6425704CE2B96986" modified="2014-10-29" version="1">MKRTDQELIFNEETSTAMRKRSMVNNEFFADVVFVVGPEKKRIFAHKLLLVMSSEYFYIMFNGNFAESKTGEVVLEEDDPDLFLTILRYIYTDEINFTLENIRDIYNSAKKFMLTELIALVKEYMMKQINEGSVLRILNENQPYGFPCVTTKCLEVISDNPTFYFKHEDFRKIDRPTLEMILNLKQINCSDDNLQNALEIWADCGEREEEFVNLWKLIRDQKRSYNCSELRLFGQRRNNGYQPVDLEFTLKSQNPVSLYGLGMFIASPSKQVSVELKIFQGENQLVANKYDVANKFVDITHVVNLFFEKVVLLPYCKLVMEKTRGRKLLQELNFNEETSTAMRKRSMVNNEFLADVVFVVGPEKKRIFAHKLLLVMSSEYFYIMFNGNFAESKTGEVVLEEDDPDLFLTILRYIYTDEINFTLENIRDIYNSAKKFMLTELSALVKEYMMKQINEGSVLRILNENQPYGFPCVTAKCLEVISDNPTFYFKHEDLRKIDRPTLEMILNLKQINCSDDNLENALEIWAGCGEREEEFVNLWKLIRDQKRSYNCSELCFGLNIPVDLEFMVNSRNPMSLYGLRIFIKPSSNMVSIELKIFQGENQLVANKYDIANRRIGITQSADLFFEKVVLLPYYKYKINVTNSDRMHELRGAKQVQMNNLAVIQRIGRDLMNVLHGFYENTRTCPSRPTVVARVHRSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEZ4</accession>
    <name>A0A084WEZ4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yip1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00016798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEZ4"/>
    <dbReference type="STRING" id="74873.A0A084WEZ4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016798-RA">
        <property type="protein sequence ID" value="ASIC016798-PA"/>
        <property type="gene ID" value="ASIC016798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016798"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003287"/>
    <dbReference type="OrthoDB" id="6407068at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026698">
        <property type="entry name" value="UPF_C3orf38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15008">
        <property type="entry name" value="DUF4518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="381"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB48788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016798-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="588" mass="65767" checksum="3E4EE031FA5B14DB" modified="2014-10-29" version="1">MVISADHERNGIADFFTQVDPEVRKVTLAIGNIISKNSIKEITLEKSLNVMMEHCRDAGTLLAKNIVKAEYLYKYLQSYNINLPQDSTKAMLIEHCLQLWRRKYGNPADVSNVPFSNDLPGPSSTSYAFPSTSAGSSSSSGTTLQNHIDNYNALAATSNGVFFSENTNGPGEPEDEPPGLEQYPVNLLALDYTVWFFLKWNRNSLDETAFWMDATCTVMLEISETQQGTEQVCGPQDIINLILSLKFQYSFQLVPNIMFDGCQGRIMDSEVLALSCGVVYNNQPGPDNRFVCLGEFDTLIALRRDPMENNNWKVRMLKLYIKYKKVDNLPALANSKMLNNCDSSAKSSSIFSFEYYQQFFNVDTMIVVDRIATSMIPKRAPSNYLKLHIATNPDLYGPVWIVITLIFAIAISGNMASYIQNSGDHHWRYNFHLVSYSATAIMLYTVFVPCALWAFLKWSIQPTDLDDEEDEPLTPSLLSLVCIYGYSLAIYIPVSVLWTVQVSLIQWLLVITGAFLSGFALLTILMPAIKKSKYSLLVVLAIEVAHFALAAGFMLYFFHAPDSVGPVEEPVHKAVTSVVVNTTVHKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WF95</accession>
    <name>A0A084WF95_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017152</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WF95"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017152-RA">
        <property type="protein sequence ID" value="ASIC017152-PA"/>
        <property type="gene ID" value="ASIC017152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017152"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017152-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="88" mass="9224" checksum="3DC3F27D3BC42D79" modified="2014-10-29" version="1">MLGFRVVFSHSSSSGSFPSEGKTPESPGGGGGCGKQRKCISRGDVARDRTYCFTDSSVITADSSSALTVTRERIIGIEQHMPPGSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WFI0</accession>
    <name>A0A084WFI0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP000493-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00016978</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525342">
        <property type="protein sequence ID" value="KFB48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WFI0"/>
    <dbReference type="STRING" id="74873.A0A084WFI0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016978-RA">
        <property type="protein sequence ID" value="ASIC016978-PA"/>
        <property type="gene ID" value="ASIC016978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016978"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017004"/>
    <dbReference type="OMA" id="TAKANCF"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016978-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="111" mass="13155" checksum="806FD4FD147E6625" modified="2014-10-29" version="1">MKKKGVFFFNIVQWTPIKYLGYSYPLWAHAFGWFTALSSMLCIPGYMIWLWRNTPGDRANVSSYYLILLIRPFAHRYISITQKIRLIVRIEDSVSQLRERMQADAEKGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WH97</accession>
    <name>A0A084WH97_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017604</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WH97"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017604-RA">
        <property type="protein sequence ID" value="ASIC017604-PA"/>
        <property type="gene ID" value="ASIC017604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017604"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017604-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="59" mass="6405" checksum="D6F5B26C719D4921" modified="2014-10-29" version="1">MTPRRNPSVNPSMSNKIETDVPERTGSVMKIAPVNHKMGRIEGSRPGRPLMAIVYVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WHF4</accession>
    <name>A0A084WHF4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00017669</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525346">
        <property type="protein sequence ID" value="KFB49648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WHF4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017669-RA">
        <property type="protein sequence ID" value="ASIC017669-PA"/>
        <property type="gene ID" value="ASIC017669"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017669"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008991"/>
    <dbReference type="OrthoDB" id="8029708at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB49648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017669-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="97" mass="10389" checksum="F746E8041EE43BA4" modified="2014-10-29" version="1">MKPFDNATAGAAIVTEWEDNVVFDADDPDFSTGTATAASVLMRSASGTQQQQQQMAKLASNLTRSVTTYYGLNSASVVSNFNHLMKGEFISYDKGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WI11</accession>
    <name>A0A084WI11_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WI11"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017879-RA">
        <property type="protein sequence ID" value="ASIC017879-PA"/>
        <property type="gene ID" value="ASIC017879"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017879"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017879-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="100" mass="10671" checksum="237A2BD85FE55E99" modified="2014-10-29" version="1">MALEPAGVNINPSSNQPSGSLAVSPPCSLSGVDDENPPLDLGRPAEEAHSDVNNQHSEFRHVIVRVETFSGLVVDMIVTLTLIDCSLHLSHNVNRTGKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIA4</accession>
    <name>A0A084WIA4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP012093-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00017984</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB49948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIA4"/>
    <dbReference type="STRING" id="74873.A0A084WIA4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC017984-RA">
        <property type="protein sequence ID" value="ASIC017984-PA"/>
        <property type="gene ID" value="ASIC017984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC017984"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005916"/>
    <dbReference type="OMA" id="KFMLARR"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784808" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB49948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC017984-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="178" mass="19820" checksum="A8986569B1DEB452" modified="2014-10-29" version="1">MTKFILARSCLELASAGTLGSSIVSSTASIVPQMGASWMRQYSLRLRTQHARLSSFTGGPICSNHFSTQADNRKPVAFDDGDRPPSDPEAVHADLLKRLTKLYDQELARKLIVPPFKRALLYGEKAAVRDQVGDFSFIQLYEAVKRLAVQISKQCALGNAKVRVRSRPTLNWSLGWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WIU2</accession>
    <name>A0A084WIU2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00018194</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WIU2"/>
    <dbReference type="STRING" id="74873.A0A084WIU2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018194-RA">
        <property type="protein sequence ID" value="ASIC018194-PA"/>
        <property type="gene ID" value="ASIC018194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018194"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019480"/>
    <dbReference type="OMA" id="NPYRHAT"/>
    <dbReference type="OrthoDB" id="5818798at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB50136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018194-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="109" mass="12888" checksum="BA0F6FF8AF2811F4" modified="2014-10-29" version="1">MGQDGALQEKAARRAALRNEYWRTMTNPHNHLRGESGGVFDTGLARFQAMRVNHFEHFKPTGRSFKIGMLTVVLPIFVYAKMMKYERDQREQQYRTGQVAYKDRRFKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WJ42</accession>
    <name>A0A084WJ42_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00018308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with Pde6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01023972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525347">
        <property type="protein sequence ID" value="KFB50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WJ42"/>
    <dbReference type="STRING" id="74873.A0A084WJ42"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018308-RA">
        <property type="protein sequence ID" value="ASIC018308-PA"/>
        <property type="gene ID" value="ASIC018308"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018308"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS011303"/>
    <dbReference type="OMA" id="STNTWQN"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000002">
        <property type="entry name" value="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017287">
        <property type="entry name" value="Rhodop-sen_GMP-Pdiesterase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037825">
        <property type="entry name" value="GMP-Pdiesterase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="8">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018308-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="151" mass="17364" checksum="99395B47C13E1EE5" modified="2014-10-29" version="1">MGTDDLSKGEKILNGFQINWMILRDADTGQIIWQENKDFSCPDVEHEAKVPVKILGLRAVSREINFSTVESMENFRLDQKVLFKGRIMEEWLFEMGWVSPNTTNTWQSTIEAAPESQMMPAKVLNGNVTIETSFYDGETFISKSVVRLYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKK2</accession>
    <name>A0A084WKK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00018792</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525349">
        <property type="protein sequence ID" value="KFB50746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018792-RA">
        <property type="protein sequence ID" value="ASIC018792-PA"/>
        <property type="gene ID" value="ASIC018792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018792"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB50746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018792-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7078" checksum="1B01025E6BD8F21B" modified="2014-10-29" version="1">MVKYSSKEGGFRAATDYTGTTEGYSLSGTDGRATDRMNRDARREFSQCYSLFSRSRSLKSYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WKT8</accession>
    <name>A0A084WKT8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KTI12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00018956</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB50832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WKT8"/>
    <dbReference type="STRING" id="74873.A0A084WKT8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC018956-RA">
        <property type="protein sequence ID" value="ASIC018956-PA"/>
        <property type="gene ID" value="ASIC018956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC018956"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013611"/>
    <dbReference type="OMA" id="THSRWDK"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB50832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC018956-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="340" mass="38535" checksum="468A4882D19E8D43" modified="2014-10-29" version="1">MPLIVITGLPRSGKTTQAKELEKYFTDAGKGPVHIVSEAECIERSGYGVKESFIDTAKEKQIRASLKSEAMKLLSKTSLVIIDGANYIKGYRYEIYCVSKNARTTQCTVYCAMTLEQRNARREEIAQNATDALDGETFDALCQRYEEPQDTSRWDRPLFTIYGEETLDLSRISSALYEQAPLPPNLATQNMPLSATNFLFELDKTTQTIIDQIAAARKIGLDGPVEIPQAGMRAEVPPNMSVAQLNRHRRQFLNYVKMHTNVSSDIKKIPAIFVLKVKAYKEKITRIKMQMHQIHQRTKNLRAKALEIQELKVNQCATKLQQLHYEESLVASSKRTARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLK2</accession>
    <name>A0A084WLK2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00019153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525350">
        <property type="protein sequence ID" value="KFB51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLK2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019153-RA">
        <property type="protein sequence ID" value="ASIC019153-PA"/>
        <property type="gene ID" value="ASIC019153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019153"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005000"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019153-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="135" mass="15191" checksum="EA59F3B28BB089C7" modified="2014-10-29" version="1">MENTPNQRHQPRITGWNRACNRLPAKKHSLHSTSLRCNTTLNGRSLHRFHHTKHTICTHYCTHGTARITSSSERVDIVAENNIHTRKAHQRENAPLTGSATKPGLNRSMLRKVCFILTARLPTTQLGETGNAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WLW4</accession>
    <name>A0A084WLW4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP011063-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00019472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024303">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525351">
        <property type="protein sequence ID" value="KFB51208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WLW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019472-RA">
        <property type="protein sequence ID" value="ASIC019472-PA"/>
        <property type="gene ID" value="ASIC019472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003214"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785132" evidence="6">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB51208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11907" checksum="FEC52D716E860853" modified="2014-10-29" version="1">MRSTRFRFTLATALVLLVAIGSWSDRQGVTAQLSELDCSDPRNVGIFLPHPSSCQKYLNCWGGLLVEGTCPLGLFFDLERQVCESEARVRCAEPGKEPTLDEEIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WMY3</accession>
    <name>A0A084WMY3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006790-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00019647</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WMY3"/>
    <dbReference type="STRING" id="74873.A0A084WMY3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019647-RA">
        <property type="protein sequence ID" value="ASIC019647-PA"/>
        <property type="gene ID" value="ASIC019647"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019647"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005377"/>
    <dbReference type="OMA" id="NCAKKHR"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019647-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="245" mass="27809" checksum="A7DCDF7B5884959D" modified="2014-10-29" version="1">MVALVGQTLKQNREKKTNLPLGIAPTAEQLSYGEDQIYSSCLEVPSKVTGKYLIRLSDDAEPVNLLCDMQSVDVGWIVIQHRFNGSELFYRGWNDYRDGFGSLDGEFWLGLERISTILNNGGQWEIMFWMMNFQRQIRFSKFNNISLGNATDGYTLKQVGKYSGNGGDSISPHNGMKFTTFDRDNDPARYNCAKKHRGGWWYHKTCVTSNLNGEYKNAINDLANSWLTMGSAGLMQSKIMIRQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WN16</accession>
    <name>A0A084WN16_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AGAP007370-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00019683</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525352">
        <property type="protein sequence ID" value="KFB51610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WN16"/>
    <dbReference type="STRING" id="74873.A0A084WN16"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019683-RA">
        <property type="protein sequence ID" value="ASIC019683-PA"/>
        <property type="gene ID" value="ASIC019683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019683"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022054"/>
    <dbReference type="OMA" id="FYNAAFW"/>
    <dbReference type="OrthoDB" id="7907111at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF104">
        <property type="entry name" value="AGAP010328-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001785238" evidence="5">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB51610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019683-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="300" mass="33517" checksum="B63BAC4CF262AED7" modified="2014-10-29" version="1">MKTLSVVCFGVILVGVLNNCAANFGTVSFDYDTVINFLVYDWNKNTFADQGTLETNFDAFGCKVTDPFVVVVHGWKEGCSNTQWVRDTLNNFVLKRKGCILCINYATIANIDYSKAVEQVDAVARTLEKKVRQLFTFGLTPENGMLYAFSLGAHVAFQAGRNLGTQKLARIDACDPVWLGFDLNSTYTALSVMDSATSVQCIHTSTDYGTSRRVCHKDWLMGYCGWFQFAAGTKSSHGLCPEFYNAAFWFDFPAISNPYYCPTTRAVSSWPSGFKMGYFMPQTSFVGDLFARTSTQYPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNJ6</accession>
    <name>A0A084WNJ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00019942</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01024617">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525353">
        <property type="protein sequence ID" value="KFB51790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNJ6"/>
    <dbReference type="STRING" id="74873.A0A084WNJ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC019942-RA">
        <property type="protein sequence ID" value="ASIC019942-PA"/>
        <property type="gene ID" value="ASIC019942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC019942"/>
    <dbReference type="OMA" id="CYANEFR"/>
    <dbReference type="OrthoDB" id="10020456at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF57">
        <property type="entry name" value="FI24007P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="14">
        <location>
            <begin position="418"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KFB51790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC019942-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="821" mass="91384" checksum="FE2441B058C1492F" modified="2014-10-29" version="1">MSNLNIILEIYFLALKNINEAFSYLIHLYLLHFPTSFQGTPYSGYTAASTDSHTLPSSPTPTSLGSSGPHRQSFNFWKAGSQTPLSASSSSSSFFRPPTQRSLLYKVLKVIWRYIKWPLGLLLICGLLGLVVYFLVVDRDIMSSGLLGEDGYEVDENLSIDFNDFTSANDLHDHRFPGGSTKEPKPKDTQGSGRTVDSKFSFGLDNDLLAVFGPHSRKPSYERDNHLEQHDIGTSSGWPTTTTKTSSSTGATDEQRRTESASEELPALVVKVTDAPIRKTSTISLKDYTKARVVFDDDDFLDADDGESRAKEGTTRAYEPAPAAIQVGLRGEVARGPEVRGFTSGHQNNFGVPIEEDERLLRRLNEQLMQLEQLRQKNITIPSATTDSSLYRTKVSPTLPILSRFEITTEGLKRFNISEEGICQSTSLPLCRGVLPYDLTVSNNRQLSRLEYDHFQYLINSKCSVRVAEFVCLVLEPECRPTRMGTLTPCKRICKSILEPCAHIIASSEALTATFDCDSYPDSDDRNVCEDPTRLGQCYANEFRCADKSCIPLQWKCDNIKDCQGGEDESDCKQCERDEYRCMSNDKCIPDKWRCDQYEDCPDASDELDCYYDEPTTYPSAYGSQREYPFVQVQVPNSPNGRPYITITNEDRTGAEADQTQGSRDGDREYANYGTSEEDADKYEPTAAENVPFVNRQKSRNDTSAEDSTAPGVSGDATTTDRSAEAKIEDQTEAETSRSISVPKSLVNFQDSKEIMMTSDSENDFKISSTSRDFLTTAHVSPCPEGELRCVSGICISVNQLCDRVQDCADGADEAGCTYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WNT3</accession>
    <name>A0A084WNT3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP003834-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020045</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01024686">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525357">
        <property type="protein sequence ID" value="KFB51877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WNT3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020045-RA">
        <property type="protein sequence ID" value="ASIC020045-PA"/>
        <property type="gene ID" value="ASIC020045"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020045"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008399"/>
    <dbReference type="OMA" id="LRCMNIN"/>
    <dbReference type="OrthoDB" id="6615450at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784978" evidence="2">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB51877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020045-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="317" mass="35123" checksum="38B355EFEE4F8ED1" modified="2014-10-29" version="1">MASKRSRVISLQSYLLPLAVFLLLTGSAVRVHGNTSSENRGIGPSQHCTDFNPQNALDIEQIMGIWYGSEVITHDGRDEGETVYDSCIVMHLADVTNSTPLVWDETSRFPGRGVGSPGSSNYEPRFATSYGYGSSGGGRGSYTYDQQNQQNRQGQLSNTYQNRQYAMAGEHQQEPHSMRYLRLIWDETKHTLEYTLRYNSSRPGFWISSSPQSGSMAQLQYVQFTGTVQVLKAVNNQLVLNFCQSLPGGQLFTVVLSRVPMGLAPEEVHSIRNLLRRRGLATTSVRKVCQSGAIRSDLSFGAMLLLVILSAVAKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ07</accession>
    <name>A0A084WQ07_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00020533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01025157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525370">
        <property type="protein sequence ID" value="KFB52301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ07"/>
    <dbReference type="STRING" id="74873.A0A084WQ07"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020533-RA">
        <property type="protein sequence ID" value="ASIC020533-PA"/>
        <property type="gene ID" value="ASIC020533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020533"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004434"/>
    <dbReference type="OMA" id="PQHKELK"/>
    <dbReference type="OrthoDB" id="10065127at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB52301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020533-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="891" mass="97561" checksum="6E4B27F5B836A405" modified="2014-10-29" version="1">MKVLKILQSFSQGTFITFLLLVFGVDCMGAPGYLDFDNLPETNFTCAGKVIGGYYADLEASCQMFHVCTIGQGDEPMDIKFLCLNGTVFDQETRVCERVDEVDCSKSEKFYYLNLELYGNTIIPSPEDGSSEEDGSDGGDSSSTTSTTTTTTTTTTTTTSRPPTTTTPSRRFIFNNNSNKGFTQPISSSTIATPMHAYSSTSPKTPSEQEEDYEYEDEEYGEEKPADQDSVVVPALEEDGSFSPQQFTLQQQQQQQQGGQPKTEPPTKAGGVKPAVSFQQQHFQNGGTLAVTNSHVTVTTHTTGGGQVGGNSDATPSSGTKAKPAPSQPPLTHKQKQQLEHQKRQQQEQLLQQQAITKQHEELQKRQQEAAVKQQQKAYQQQQKQVQQHEAEIKNHQAQLLLHTQKINRQQQKPNVPPSATPATQRPPFAGGASGFGVSQQQQQQQTQAPKRIPLLPSQSPLALPSPVSPLTPFRLRAQGFKLPPSVAPQTLPQQRQDILRQQQHQLQQQQQQQQQQQQHHHHQQEERFEGYRRQPPPQVPLHLPFEQQLRNQKDISLQFDPEVEDLTQIPQHKELKRSDPPFHNHGKPANGGNSKEQGSGTIAVSERKIDDNLAPQQQQQQQTEVSTGGGGAGQEPVVEYEYDEDYSSEGDEPDAGNNSSLDSVKSNTNSEFVIAKNISPGKSGEDRHPKELTSSVTSSDGRPSTNPSASSSSNNRISSSGSISSYADRSSKKPPSSGSSNTSRFIINNEHHKSSSSPPRVQPSARSGTAPAIPGVSGLAKVIVTTSTSIRDNHGRTINYSITSNGGGSVSSTVQPATTTTVRTPKAPPSSVRGYDEYKESDVLSDPFFLDVPRTGGGGVSLRPRARRSLSTSANRSRRKRFMLLVPLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WQ53</accession>
    <name>A0A084WQ53_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase A2</fullName>
            <ecNumber evidence="2">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00020562</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="ATLV01025246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525378">
        <property type="protein sequence ID" value="KFB52347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WQ53"/>
    <dbReference type="STRING" id="74873.A0A084WQ53"/>
    <dbReference type="EnsemblMetazoa" id="ASIC020562-RA">
        <property type="protein sequence ID" value="ASIC020562-PA"/>
        <property type="gene ID" value="ASIC020562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC020562"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001066"/>
    <dbReference type="OMA" id="FTISHCS"/>
    <dbReference type="OrthoDB" id="6075074at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00618">
        <property type="entry name" value="PLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
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    <feature type="domain" description="Phospholipase A2-like central" evidence="6">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="6">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB52347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC020562-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="411" mass="48210" checksum="C34C15AD5B610880" modified="2014-10-29" version="1">MELKRLANFQFESDSSSSFANSNKTLSLWQMATHKYLMQIIYNSDGDMMDCEYVRQRPLVHQFRERFIVEFAQGRARNFTSPYNFPPGAGRHSLVSDHDFREYIEHDVVTPEMDELQYNVYEFPAGVSPASVDAFGMRNLTYIPLRDRADVPEELLTQLNFHELKQRCDVRHMQLKEIATGLRSSDPEHKRIANEKLQRHKRAIADWFLSPNTKWCGKGHSAAQYHQLGGASRADMCCRKHDHCKIMIPAMATQWDLFNFRPFTISHCSCDTRQRRDLSDMLRVPGTKWCGKGWSARNYVEMGGYSKADRCCRQHDLSCPFWILGFETKYSLFNWRVNTLMHCSCDERFRTCLKMADSSDANLVGKLFFNIVQMKCFVLKPETVCVKKSWWGKCEKKIRRKRAHLRDNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRI9</accession>
    <name>A0A084WRI9_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021102</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525406">
        <property type="protein sequence ID" value="KFB52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021102-RA">
        <property type="protein sequence ID" value="ASIC021102-PA"/>
        <property type="gene ID" value="ASIC021102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021102"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023280"/>
    <dbReference type="OMA" id="ERWNENA"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021102-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="215" mass="22977" checksum="CFABFA4D690C3D69" modified="2014-10-29" version="1">MASRPSKPTKGANPGASGANFGANLSARRKSVALRTGSFDEQQLQRAEREPSPASAKGSAHLAAPGGTSSPHSPKFFRTQSFGDRLLASSPKFVKSKKIFLSVGPKSSSSTALFFAPEVPATNTKGSPAGGSSFGSRRKNVDGCTGRPPAHIAEPTTRVKQSTDGDSNDPVDIHDPLIAFRDELRQLRQLQKERFRSRSSSISVERWNENASGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRM0</accession>
    <name>A0A084WRM0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">30S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021137</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRM0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021137-RA">
        <property type="protein sequence ID" value="ASIC021137-PA"/>
        <property type="gene ID" value="ASIC021137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021137"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021075"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB52864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021137-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="6845" checksum="B31EF4FDD47B5939" modified="2014-10-29" version="1">MPPRHCVLFIVPVKLQRAALVTRKLVKHPFYGKFMIKQQPPPIDDLAARKVGSDGKCFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WRT6</accession>
    <name>A0A084WRT6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005249-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00021214</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01026197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525407">
        <property type="protein sequence ID" value="KFB52930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WRT6"/>
    <dbReference type="STRING" id="74873.A0A084WRT6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021214-RA">
        <property type="protein sequence ID" value="ASIC021214-PA"/>
        <property type="gene ID" value="ASIC021214"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021214"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003174"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000277">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="310"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="498"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="618"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB52930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021214-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="862" mass="96870" checksum="E3245B6CE1FC9FCC" modified="2014-10-29" version="1">MSRIIIKNIPNGFDETKLRNHFSTCGIITDVQLKYTPEGKFRNFGFIGYENEDQATKAIKHFNNTFIRTSKISVAPCVALSETKNLKVWSKHSKQQEEKAKQEQEGTEAPEKEKSKPLTAKDVLGRHENDPLFQEYLDAHKRPGKAVWDNQFQHAEPESQSAATDRKASSEDSAIEADDSPPPAKTKESTESKEKPKKDLIPLFVAKLNNIPINTKRQDVIRFFKTTKPYSVRIPRNSKGFAYVGFKTESELKKALLMNKSFLGGKQVKIYDFTAQNGDVSKVKEEKRGKEAKWERQRMNQSSETICESGKLFFRNLAYSVKEEDIRELFERYGPVVEVDVPIDSLTRKVKGFGTATFLMPEHAVVAYNELNGTFLQGRMFHILPAIVKNDEQAEEEATDGTNFKKKKEQLLKKTAQSSHNWNTLFMGENAVAEAVARKYDTTKEQVLISADGTGSTSAAVRLALGETEIVLEMQKFLEENGIRLDSFESSNGKRSNTVILAKNLAPGCTVQDLRRLFAPFGILGRVVMPPSAVTAVIEFLDPSEARKAFKKLAYTVFQSLPLYLEWAPENTFKSAATEDELKRLKEEETTATSEPPKTKAAAAIEDPVDDTEPEEGTTLFIKNLSFSTTEDAIRERFRNVGAIHSVQIVRSKDLSGTGQNESRGYGFIQFKLRKSADHALKNLQFAQIDGRTVELARSDRTLKSAHDAQDGRKSAKAKKQTGSKILVRNIPFQANAREVRDLFKVFGDIQSLRLPKKMAAGADESHRGFCFVDFVQEPDAKRAFETLSRSTHLYGRRLVLEWAAPEDGVDELRKRTAEHFEGSSSKRPNNRKGALMSEEFVSVRNTGNGDDDYMDDDGGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WS65</accession>
    <name>A0A084WS65_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Pyruvate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00021255</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525409">
        <property type="protein sequence ID" value="KFB53059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WS65"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021255-RA">
        <property type="protein sequence ID" value="ASIC021255-PA"/>
        <property type="gene ID" value="ASIC021255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021255"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB53059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021255-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="128" mass="14546" checksum="1E826567A95D9351" modified="2014-10-29" version="1">MKIKIDTPPEVVLECFERRTNATRYLTQRSRNVVLAYAGCFLLNGKPAKTCTLEWRPRTNSGPLQLTATQKRICRGSCEAIEHKEAYRPAKGNQPNTHHFGALNGFTIFVRHARGCSCAFVRVQRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WSS8</accession>
    <name>A0A084WSS8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00021576</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026708">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525417">
        <property type="protein sequence ID" value="KFB53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WSS8"/>
    <dbReference type="STRING" id="74873.A0A084WSS8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021576-RA">
        <property type="protein sequence ID" value="ASIC021576-PA"/>
        <property type="gene ID" value="ASIC021576"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021576"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006163"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013946"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040312">
        <property type="entry name" value="FWCH1/FWCH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31665:SF0">
        <property type="entry name" value="FLYWCH FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31665">
        <property type="entry name" value="FLYWCH FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021576-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="342" mass="39254" checksum="405F2E5512BE4474" modified="2014-10-29" version="1">MILFNPSHHFHPVLVAPKRPEPLKIHIAVPKRQTVEILEEVHITVPAKRQSSLLENILLSDTPDERKHKFLTSRKGGVQLIHEEYLYRSNLRRQGKEGDILYWECIHNRGTKCRGRLKTVGNTIHKSNGKVQRTDLYADASPPPPPTPTKKPPMNATELKFIKSPWSTPCLVLDNYLYNCHSTRGDIGYWRCHNYSRKVKEERCRARCVIKCGRLSALTGAQHNHPPHTEKIDRIMRRNYADEQMQECQQQQQEQQQEQFYQAAPDTHRNRDMIMLVASNTTTNRHCSREAVVEMPVELAVVNDGNGHSNETPLPTTSSSVIAHLLTNGIKLDDYTLPVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTD2</accession>
    <name>A0A084WTD2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002588-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021984</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTD2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021984-RA">
        <property type="protein sequence ID" value="ASIC021984-PA"/>
        <property type="gene ID" value="ASIC021984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021984"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002533"/>
    <dbReference type="OrthoDB" id="7732702at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021984-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="144" mass="16086" checksum="8BB49818A6E5B892" modified="2014-10-29" version="1">MANMASHGMSSHETLQTPSRRVVGLHLQNEYYESASVPSTPDKNTVSLDNRGSFDHAQQIPEKPHIVEPTWITVTMPPVYLPSGHSAQSGQPPIMQPYYTYIPVPPVNQPWSGPWPMYHPPMPVLPPLPSNHLCNQPSNPYRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WTF6</accession>
    <name>A0A084WTF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00021726</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01026890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525420">
        <property type="protein sequence ID" value="KFB53500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WTF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC021726-RA">
        <property type="protein sequence ID" value="ASIC021726-PA"/>
        <property type="gene ID" value="ASIC021726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC021726"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB53500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC021726-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15437" checksum="095BA51460DC8239" modified="2014-10-29" version="1">MTVASRWQSHLGYVEEKSMHSWRPIGTRDGNETIERSDDGPLERLGYYLTLFLILRPCHETTGSGKVAIVLLGVNIVGHNAAKGCQFVPAFGKGSACSTKNGTDRKRYEKIPSAVCSESREEKSITSHKAPFPLTEPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUJ0</accession>
    <name>A0A084WUJ0_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Protein kinase C</fullName>
            <ecNumber evidence="2 16">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">ZHAS_00022329</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="26 28" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 16"/>
    <dbReference type="EMBL" id="ATLV01027092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01027093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUJ0"/>
    <dbReference type="STRING" id="74873.A0A084WUJ0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022329-RA">
        <property type="protein sequence ID" value="ASIC022329-PA"/>
        <property type="gene ID" value="ASIC022329"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022329"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000500"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS020720"/>
    <dbReference type="OMA" id="VVXQLKE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="161"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="338"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="597"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="344"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KFB53884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022329-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="667" mass="76693" checksum="52253128BD32B12A" modified="2014-10-29" version="1">MADEDQCLEEIPDAENKNLLRNRGRKGALKKKNVYNVKDHRFIPRFFKQPTFCSHCKDFIWGFGKQGFQCQVCSFVVHKRCHEYVTFKCPGADKGADSDDTRTKHEFKEWTYSSPTFCDHCGSLLYGLIHQGLKCTACDMNVHKRCEESVPNLCGCDHTERRGRIQLAITHSAGKLHIEVKQGRNLIPMDPNGSSDPYVKIKLIPDADNVKKKTKTIRASLNPVWNETLIFDLKAEDKDRRLLVEVWDWDRTSRNDFMGSLSFGISEILKNPVDGWFKLLTQEEGEYYNVPVPEEGADLVQLKSQMRKTSITKKIPLMSDKDVPHNMTKKDVIRATDFNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDIIIQDDDVECTMVEKRVLALSSKPPFLVQLHSCFQTMDRLYFVMEYVNGGDLMFQIQQCGKFKEPVAVFYASEIAIGLFYLHARGIVYRDLKLDNVLLDQDGHIKIADFGMCKEGILGEKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHNVSYPKSLSKEAKDVCKGLLTKNPQKRLGCGARGEEDVRAHAFFRRIDWEKIENREVQPPFKPKIKHRKDVSNFDRQFTSEKTDLTPTDKLFMMNLDQTEFNGFSYLNPEYVQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUT4</accession>
    <name>A0A084WUT4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dmoj\GI17037-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00022229</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB53978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUT4"/>
    <dbReference type="STRING" id="74873.A0A084WUT4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022229-RA">
        <property type="protein sequence ID" value="ASIC022229-PA"/>
        <property type="gene ID" value="ASIC022229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022229"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS001011"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB53978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022229-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="125" mass="14342" checksum="20BD99CD7F5F627D" modified="2014-10-29" version="1">MTTRSTCYGCVRDNASAINSGINKANVDRRSPVDREPPTRVHLEPVERKKREKKKRKNQANITWRSCQEEEEKEKGNEFFKKGDYSTAVKHYSEAIKRNPDDAKLYSNRAACYTKLAAFDLGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WUW2</accession>
    <name>A0A084WUW2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00022260</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01027155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525423">
        <property type="protein sequence ID" value="KFB54006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WUW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC022260-RA">
        <property type="protein sequence ID" value="ASIC022260-PA"/>
        <property type="gene ID" value="ASIC022260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC022260"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB54006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC022260-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="7932" checksum="01A1E421A070C9EA" modified="2014-10-29" version="1">MEEIIANLVHSFGASDVRLHSGGFRSSGPKSLPGSGTGTSGTDGVSQVCWLELNAFPIRPAAGLQQTGSRRCRFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VAV7</accession>
    <name>A0A084VAV7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Envelope glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00000983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01004496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524215">
        <property type="protein sequence ID" value="KFB35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VAV7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC000983-RA">
        <property type="protein sequence ID" value="ASIC000983-PA"/>
        <property type="gene ID" value="ASIC000983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC000983"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC000983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="115" mass="12903" checksum="439171116A6E4D5B" modified="2014-10-29" version="1">MALRIMFRTLYRESDHFDGIGSSRGRTDTDLRSICPELQGNQQRRGRKEAEGGETDGGLTYRFATLSYTDARQEPTRDTIVLAGSPCGSYGHSVGRASNEYGVEKHCNIKKREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDL7</accession>
    <name>A0A084VDL7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AGAP005448-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">DUF1619 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ZHAS_00003090</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01011630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524705">
        <property type="protein sequence ID" value="KFB36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDL7"/>
    <dbReference type="STRING" id="74873.A0A084VDL7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003090-RA">
        <property type="protein sequence ID" value="ASIC003090-PA"/>
        <property type="gene ID" value="ASIC003090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003090"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS023492"/>
    <dbReference type="OMA" id="DFQYNHG"/>
    <dbReference type="OrthoDB" id="2104337at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF2">
        <property type="entry name" value="TECTONIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011842599" evidence="6">
        <location>
            <begin position="16"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="7">
        <location>
            <begin position="231"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003090-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="708" mass="79907" checksum="46585D5E37D040F0" modified="2014-10-29" version="1">MLLYITLLLAVVIDAKDDRNVQRFVKIDLSKINVKNTTDSNNVSTTTTETPTTIEGSTTLGTSGPTTAAPSNITSTTAVPTTESTPSTVPAVTTSTATTVDSTMSIDFDPTFPPLKEGRAAKLVPRGYFCQCDLKINTCDVNCCCDIDCNEAILKAFHCDEEQLHRDEYHHDEGLQSCRVQGGLFCLVEPIHEEGDESYYDPKRLPDATRFKWKDVFPVDATEPNDIRIDHYRVGDTMYFFNETSETVQVFDLPYSLTNSVCQITQPVRFLRESSNLCRRTVEELVAFNRAFVEHHRSVRFFRTPKKSTVMEHYCVEEQDCINVTLSVCHSVDETGTGWNCSAHNINTTSNATSDTTVDFLEDDVGSMGSCDRLEIDFFNNYTHLLEVRMKLFCHPDTPDSWMDTSVWQRVAVKFPVASRKHSNSTRSVSGNLGYLIGKPLIVSHLELGRNGTLKTGGSEPNVPSERPLKPMLAYFTNGTRLPDESFRLRLPISKANRCTLTDESYQTINFGVDCWQRCNFVLVEGGWNVSTESTQNYTQLCRQLQEKLYDHLLHGVRKTSDGYDNLNLYLSKYGNPINKTTDWIQLRSVNVIAEAQPGSDTDTSTTHEGGQDYFTCSNMLINVDYRFYYARQRVHDVRHQAILHTGEVVFGPRVNLRFRRDEEVRVPIFVQVQFFDLTSSGGIGRTTQADLLLLGILVCLCVCIFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VDY6</accession>
    <name>A0A084VDY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00003263</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01011963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524742">
        <property type="protein sequence ID" value="KFB36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VDY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003263-RA">
        <property type="protein sequence ID" value="ASIC003263-PA"/>
        <property type="gene ID" value="ASIC003263"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003263"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003263-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6394" checksum="F1BF76600AD7AF6E" modified="2014-10-29" version="1">MTRHNEEDGGKSHPTKWGGHHRRQATGRGGSEPSGEWEGKKHPSLHDTSTLANLNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEG0</accession>
    <name>A0A084VEG0_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003507</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012275">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEG0"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003507-RA">
        <property type="protein sequence ID" value="ASIC003507-PA"/>
        <property type="gene ID" value="ASIC003507"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003507"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003507-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="86" mass="9802" checksum="504792E4AEE6006D" modified="2014-10-29" version="1">MCKVAATGKNSLLLDNNKRVRSFFRKPRYTHFCSVWYIIDGRSGTRRTPHDARRPEAAAAAPASLQHRAARMQHRHRATVRFNGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VEI9</accession>
    <name>A0A084VEI9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Solute carrier family 22 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00003546</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524778">
        <property type="protein sequence ID" value="KFB36383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VEI9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003546-RA">
        <property type="protein sequence ID" value="ASIC003546-PA"/>
        <property type="gene ID" value="ASIC003546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003546"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003546-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="92" mass="10171" checksum="E647A8FACAFEE988" modified="2014-10-29" version="1">MWKAISSEAAASSLRSANVLPVSLRRVAFPRRAELLTIAQHCRGPAPAGHAMCLCMGREKPCHRQRFSAKANFSLPQMQTPTYSGGWILRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFS5</accession>
    <name>A0A084VFS5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000356-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00003982</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ATLV01012459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524793">
        <property type="protein sequence ID" value="KFB36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFS5"/>
    <dbReference type="STRING" id="74873.A0A084VFS5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC003982-RA">
        <property type="protein sequence ID" value="ASIC003982-PA"/>
        <property type="gene ID" value="ASIC003982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC003982"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003575"/>
    <dbReference type="OMA" id="DAKMDHI"/>
    <dbReference type="OrthoDB" id="7726247at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC003982-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="200" mass="22580" checksum="F19E6F23D7CFC426" modified="2014-10-29" version="1">MILDLHNEARDRLASGAEKGAEFAPASRMPTVVWDDELANLAEINVRGCKFEHDECRSTDKFLHAGQNLATGSYYLETDILAIVRNLTTLWYHEFEDTTQHVLDNYTTEFNATIGHYTQMISDRTTAVGCGIVIYPNKMEDFVFKTVLYACNYAITSIVGQPVYLKGEPTSRCRSGRNLAFSSLCNVEENELIKAVPFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VFV4</accession>
    <name>A0A084VFV4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00004016</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01012491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524797">
        <property type="protein sequence ID" value="KFB36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VFV4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004016-RA">
        <property type="protein sequence ID" value="ASIC004016-PA"/>
        <property type="gene ID" value="ASIC004016"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004016"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004016-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="7497" checksum="5A26C1EDB1D864ED" modified="2014-10-29" version="1">MQLLPQLLRPIPLPTLLLTTQTINLLYDRHSTKHPVAQQPMRAFRTTCYYLQLVTWIKIGTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VH49</accession>
    <name>A0A084VH49_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524841">
        <property type="protein sequence ID" value="KFB37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VH49"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004510-RA">
        <property type="protein sequence ID" value="ASIC004510-PA"/>
        <property type="gene ID" value="ASIC004510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004510"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759837" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004510-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="143" mass="15432" checksum="161319BB21CC1788" modified="2014-10-29" version="1">MHPRMGLVTLLLSVVSRRAAVKLFFGYYTGTLKLRLSTPADTSYWSFPGVDEIRPSMQIEHSPGQNGPASFKSGRTSLRRKLAQLEGADVIPTGRNALQCPAPGFSTSENPTQGWSSTASFSSDPVAGRYLMSGGPFGVHNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VI37</accession>
    <name>A0A084VI37_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">RCG62063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00004868</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524849">
        <property type="protein sequence ID" value="KFB37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VI37"/>
    <dbReference type="EnsemblMetazoa" id="ASIC004868-RA">
        <property type="protein sequence ID" value="ASIC004868-PA"/>
        <property type="gene ID" value="ASIC004868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC004868"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC004868-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="103" mass="11188" checksum="C53B68B2FF4AD216" modified="2014-10-29" version="1">MKRSDAFHRQSLASLCTNRTSIDRQQTSSATNYLLGVPLEKKGKLPVSGGGGVDVPHQGSLEQEADLLVPVNRRVLIWPRKAPYGKPAGNHGKPQNFISPFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJC7</accession>
    <name>A0A084VJC7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP000783-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00005381</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VJC7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005381-RA">
        <property type="protein sequence ID" value="ASIC005381-PA"/>
        <property type="gene ID" value="ASIC005381"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005381"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013507"/>
    <dbReference type="OMA" id="DHDPNDM"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="1265"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005381-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1781" mass="190420" checksum="82E6B448F0390448" modified="2014-10-29" version="1">MSKWSKPQGVVVPLESLLKERRKENCPAPRRSAGLVGRWGITSFTSIRNRGYVIDYGNVNPKEPGLELGSGAADSSDAISNMLGSSVEEPARPRKFFKSRNTVLPPPMPPGDLQQHVGFVPHSSPFEVAQGALATDMWNHSSTTPPQHFYQQHQLPLSAATPQVSPTGPQSANVSGLLHAGTTDGMITYGAPQPPTLPIQPVKEKAPRKKKRASSEVAACEPVACRKQVGRPPSKKEKKEKKPKRARKETTEVGSIGGISSALGGTEAGESQPKRNSSRIRNRVINYNEDEDDSNDYERARTVTSRAQPTQNTTADPGFTPDSSSLQAASKEYLPRQPSSGDGDSESLSSKPTIATSCLPSPSISEHRPILLRISKGTSMLITDNEELPCNNQQQQQQQQLVPDEDVPPGIEVNSSESLTTLKSSGGCLKTPQHTGPAPSTQEDNLFSARPVAYVSSCAAGSDAGSVSKSELKIKISLGGKPLISSTTGVGSGANTTSAGGKVKESKSGSKYNFKKRAIERERARHHLSSKRNKLADVTAASDVTALEEESGRQWFSSEATATTTTTTAVAAAASAAQLPPPPPPPVSSSTVSSPNYVSQQQQHQQQQLRHPSSVAAVAGPTVGETAGARGPRHSFPLPGTDTYEVFRTLSSLSGGDDFDSQSSILGSASSDNTPKHTLQAPGEDCQIIHSRGSSDCGSDLELSQNSSTAAAPPSDVYSEGENTQDNNHSHHQQQLNAFSTTTPSVPPVEVVSQSVPAAAIERQQPEERVEVLKINLAQATAKYDDATDSARRVTRNKTKHLSEDKEQQQAPPAEQPAKQLTLRVGRAGRSRKNNNNNNNNNVIENSMSEKRSRKALQQEEPDAAVATSQQTTSTSLPEVNDIITEVGEGDRDAMQQPSGEVFGVVGLRSGSDSLKVPAASATKPAATRQYSRKKKNVVPIDYVVVADTTGPAQELPLPQASTIQCPSLVTTSSTTGDMQQDVSGEATRLRQNGATRLVEQATNVGQDAGGDGGGKQEGKRIEPPLPAPPAPMRLVLQKKGTIFKSRPLVGSAVGGAADTKKRHVYKHKWDDNGNPPAGGVDGAVNGGTVAGSGTGAGVGVVGGSGVGGGGSDVGAEPGSLLQGLAVVEDAVGGENTGGCSNGGGLSSTGGIGTGSIEYDNDFDAESAPVVMASRSKRLRTGWPSTGAGAGGTVALGGPGVGGNISGGAHAGGLSGTGSCGGAIGGPSSFGHYQDCDVDSSGGGHQHHDELGGGGGDEGSRMRCDRNAKPFYTIVRNVKNSHQMQEIGEFQEMDDDVEYILSALQPDNPVSTRCLSALQLATKCMKPAFKMHVRAHGVVTRFFKSLSDAHQDASLGLCTAAIMYVFSQDKLNMDLDRDSLELMLNLLDTDHRSDAVGHTQQLQKIRQRVKELCEEIKGIGKAAKHIDTERWFKDELRNLGGIEHLIKTVAECYGRVPSGQASDWHEETVAKLRKIERCLRVLNNVSLLNRQNQRFLLEHRDGLLVQVLVKMYRQFDANLMRYPTDDASPKESTGVVLRELLKPILHMLITLTHSFDEEAYGAHLVGKQPDVINITMHLLLQIAECVPHRCVFDFHLLVLTLLLHLARPSQHNRQQVLLYQDAHTGRGGIKALVEYFEEQEEMASHAEAKTNAILETPARTVDAEDAETKLIQKAEHHMEHTYMGSHVCMLIYHLVLDDPVHEHVARLHLKNNDFRRMVAALTRYYEFLNLTTNADAESTAHKRQTKDAIDYLSRLDGCETAGGVTRSGNETTAALTHSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJF5</accession>
    <name>A0A084VJF5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP013441-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524867">
        <property type="protein sequence ID" value="KFB38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJF5"/>
    <dbReference type="STRING" id="74873.A0A084VJF5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005374-RA">
        <property type="protein sequence ID" value="ASIC005374-PA"/>
        <property type="gene ID" value="ASIC005374"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005374"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018960"/>
    <dbReference type="OMA" id="MREMARY"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005374-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="366" mass="36494" checksum="4217C8585F6F8817" modified="2014-10-29" version="1">MAALRAKCRATGRPMPAHRKATGITEVFRRPAQARHRCKGRPTRERPGSSTQAMPPGTPNAQPHVGYGPPGQPPQVQYPPQGGPGAPPPPHGYPGYPTSAAAAGSVAGGGPNGPYGQPGGPAPQNQVGGYPVANNQSTGYGMSQQPHYPTGYPGAGQAGPHGGGPPNTANVIPTSVAGASQSGAAGAGGQQGAAYPGHQQPGVPNATGAGPASASMPPTTTSAYPTVAPVGGISAGAGSVPPGGAGSYNSSPTAQQQQQQHGQPPGTGYQQQQQAGANAAGNVVPQQQQQQQPGGPGGPGVYPPHPPYHQQSAYAPLPVPQGQYPPAQTGYPQYPQRPPSTQMPPPGPQGPPPQSSYGYVYGQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJL6</accession>
    <name>A0A084VJL6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00005456</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01013735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524884">
        <property type="protein sequence ID" value="KFB38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJL6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005456-RA">
        <property type="protein sequence ID" value="ASIC005456-PA"/>
        <property type="gene ID" value="ASIC005456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005456"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005456-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="9269" checksum="80800248541CDA74" modified="2014-10-29" version="1">MLSFAKVYAKPETRNQTDEMESSEAPTVRVRARLLAVYISCLTAHALMILYLRRGFNFPAHKRCSNDASPCIGERFAAECSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJS5</accession>
    <name>A0A084VJS5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AGAP004324-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ZHAS_00005533</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524905">
        <property type="protein sequence ID" value="KFB38219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJS5"/>
    <dbReference type="STRING" id="74873.A0A084VJS5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005533-RA">
        <property type="protein sequence ID" value="ASIC005533-PA"/>
        <property type="gene ID" value="ASIC005533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005533"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006779"/>
    <dbReference type="OMA" id="QSTSHAY"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF10">
        <property type="entry name" value="L-DOPACHROME TAUTOMERASE YELLOW-F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KFB38219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005533-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="142" mass="15830" checksum="B1AF59CBDB2FB0D4" modified="2014-10-29" version="1">MASTGEIVVSNRVLQNETLAGLGNGVYASAFRHLGSRGPNTQSTSHAYDPVTGVLFYAEVNRNSIGCWNTNRPFTPDNHGIVHLDNEEMIYPADLKIDSEGNLWVISNRLPIWIYSRLNTTDVNYRIWRQSAFRAAAGTICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VJU9</accession>
    <name>A0A084VJU9_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00005597</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01013894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01013895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524908">
        <property type="protein sequence ID" value="KFB38243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VJU9"/>
    <dbReference type="STRING" id="74873.A0A084VJU9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005597-RA">
        <property type="protein sequence ID" value="ASIC005597-PA"/>
        <property type="gene ID" value="ASIC005597"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005597"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016496"/>
    <dbReference type="OMA" id="DSCCKTR"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03155">
        <property type="entry name" value="CD151_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB38243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005597-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="224" mass="24952" checksum="A7266D5B3B3DD33B" modified="2014-10-29" version="1">MVIVGVTLWTVFWKHQYISLLSTTNYVIGTYALLAAGVLAVVGGVLGCCAVCHEHRGILLMYTFILLFVFLLEAIVGGLAYLYETQIETELQHSLNSTFGEYYGVSESQTQAIDSMQQEFSCCGAVRFEDWRNSVWLRSRRKDLIRPTEGRLVPDSCCITVSPLCGMRDGPSNIHYTGCIYQMTDDVKQHLILLGAIGLGLSVIQIFGMILSCCLYVKLKNVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VKW2</accession>
    <name>A0A084VKW2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00005983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524956">
        <property type="protein sequence ID" value="KFB38606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VKW2"/>
    <dbReference type="STRING" id="74873.A0A084VKW2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC005983-RA">
        <property type="protein sequence ID" value="ASIC005983-PA"/>
        <property type="gene ID" value="ASIC005983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC005983"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008324"/>
    <dbReference type="OMA" id="MSDSANY"/>
    <dbReference type="OrthoDB" id="6478865at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC005983-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39212" checksum="3A7E55E0090ACD30" modified="2014-10-29" version="1">MMIIPRDIGYWSFAFDAITDPNHQVVWWAYHSVHITNLNVPKTYVLDRSTYDAVGATAPPSQHTPAWYENEVTSSTTTTTSTTTDDGMPMTTSFTSSTVVDELNGTAQQHQSFGEPKPLIMDCQYEIKARECGFVLKWYFNRKLIYQWIPSRAPVGMNQFKNELQINYSMSDSVNYKYRALVIRNPKLNHSGEYMCSVQTYDSFDRRMARFQIVVPERMLLLHYENDGDSDNMLLIKCSVFMIYPEPNLLLIVSGNLFLVSSRTLVTADQNHMYNKTVYGKIDKHLLISPTSISCVLTVPDSGYIRKRETIYYDPTPLTKWSRLRMDERGRFQLLSTDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL61</accession>
    <name>A0A084VL61_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00006106</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL61"/>
    <dbReference type="STRING" id="74873.A0A084VL61"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006106-RA">
        <property type="protein sequence ID" value="ASIC006106-PA"/>
        <property type="gene ID" value="ASIC006106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006106"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017063"/>
    <dbReference type="OMA" id="CWRSCQF"/>
    <dbReference type="OrthoDB" id="9991972at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB38705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006106-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="284" mass="32800" checksum="DF273431A40615FA" modified="2014-10-29" version="1">MHLTDAAAAAGYPLEAAETIATTIGGVDKTSVRELLTTVPELAKYTPDQWQQTHRLLASEGLETEKILSIIGGHPSILTRPTEKIAESLHCWRSCQFGDSNMKVLMSAHPYLLEYTNHGQLSQRVAFLHSHFETRKNVYRLFMNAPNLLVEEQRETEEKIDFLMEKMRHEVLEVVKSCAFSHDLEHLRCRHTFLERLGLFKPRSLKADPNTPTGNPKLHQITDTSDKRFAVKVAYVTLEEYEVFQELFRREMSADDYEDWNDELDGEDESENESNRETYRKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL65</accession>
    <name>A0A084VL65_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00006110</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL65"/>
    <dbReference type="STRING" id="74873.A0A084VL65"/>
    <dbReference type="MEROPS" id="C54.A04"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006110-RA">
        <property type="protein sequence ID" value="ASIC006110-PA"/>
        <property type="gene ID" value="ASIC006110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006110"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS019297"/>
    <dbReference type="OMA" id="TGFGCMI"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB38709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006110-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="388" mass="43791" checksum="3C86F5262E6AC910" modified="2014-10-29" version="1">MDMLDAYVGYDLSSCTEPDDIPKTNETVWLLGKQYNASEDLEAIRDDVQSRLWCTYRRGFVPIGSTTLTTDKGWGCMLRCGQMVLAQALIQLHLGRDWRWSLDTMDETYLKIVNRFEDSKQAPFSLHQIALMGDSSEEKRIGEWFGPNTVAQVLKKLVKFDDWCKLVIHVALDNTLATDEILELCTTKDPDAWKPLLLIIPLRLGLSEVNPIYIEGLKKCFQLPGNCGMIGGRPNQALYFIGYVGDEALYLDPHTVQRVGSVGDKREATEQEQDETFHQRYASRIKFASMDPSLAVCFLCVNRRQFELLVARFNDSVNGGGSQALFEVTKTRQAPWTPTTTSSASSRKNSGPTEAFNVISATEIPNEEFEEVEPRTLDDSDEEFEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VL67</accession>
    <name>A0A084VL67_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XPG_I_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01014417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524970">
        <property type="protein sequence ID" value="KFB38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VL67"/>
    <dbReference type="STRING" id="74873.A0A084VL67"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006113-RA">
        <property type="protein sequence ID" value="ASIC006113-PA"/>
        <property type="gene ID" value="ASIC006113"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006113"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010565"/>
    <dbReference type="OMA" id="VMRCVFE"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18676">
        <property type="entry name" value="PIN_asteroid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006113-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="911" mass="104073" checksum="0C79E98318ECE70F" modified="2014-10-29" version="1">MGVRGLTTFIASKAEIFLKPHELHDTNLVIDGDNLCMQLFKKSQLTSTPLGGNYDLYHRIVLDFFHMLSMCNVVPYVLLDGGYEARKMYTVKDRLLQTIHSIKTMNHGAMSSTKPLMLREVFVDALRCAGVSVMRCPFEADDEVAILARKLNCPVMSYDSDFYIHNVQYIPYVTVTHKVYRKVADKEGENFEIGIVEWNRSKSGAKRSERVKFVAQYGDETVIKSDAVETYYYLDCCMYTLDNLIGPNVRLPKDMIPLFAVLLGNDYIERKVLAPFYSTISTGRAKRATGRQSKRIKVILKWLQNHTVQSATRSIINHVRQEKKGHVYRQILTAMRGYNCEDCVSFRYFGFTDTVLEDEEIERHIQDVLESDDDNDDADVLGEDEEEEAEESINEEDEGSDDGNNDDDELAEENDFLDEEAEAEESINEEDEGSDDSGTEPGEEIDSCGDENEAENVQDPQADAQQSSASEEEDTNDGDLKRMAPYRNKYTDHDWPEWFRELYGAAKLPRFLADLLHSNVYLNYPQVEDITKPDSNEISYPILRTIFAILKSSCSRPVYAFKYISRRVKVPGLCYVTFRDVKLPDGVQFDPASTSNVAVLEELFKDCKIDAWHDLLQSIRTLPNNLQLYFLAIIYWATNCTDANVAHVLALIVCILQLQIIDPSLKSKNRDVKLFQTQHATYLEEQRRKVLKTAKVGKSKEEEQEDQAGKFNRTFYNQLSSSTSRSELMLAYEMLIGHFTANEKLNRKHTSIDRGITHTLAEFQSVCHNLSALVSLLGYPFENVRMHELFNSMFVYNLYDTMKSRANPTEYACTTFFRSSAMLQSALRRMCKFVEKYVPDLQQRRRTVRGLAKVAGKKKANVVDSKPVKRKSAPSTKPTKPDPVGQESTSESDKDDFIDLNNKFSQLLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLX3</accession>
    <name>A0A084VLX3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006405</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLX3"/>
    <dbReference type="STRING" id="74873.A0A084VLX3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006405-RA">
        <property type="protein sequence ID" value="ASIC006405-PA"/>
        <property type="gene ID" value="ASIC006405"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006405"/>
    <dbReference type="OMA" id="KAAMMKG"/>
    <dbReference type="OrthoDB" id="10041151at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006405-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="331" mass="35583" checksum="23602C5986E80785" modified="2014-10-29" version="1">MKPPSVDMSSVTSSNNNNNNNTTHGIRASAAASSATGTCNSIVHSYANVCSGISGTGPGGVGPSGTCSSSGSSTTTPTHTASASGSAAAGVTQTGNPNGAAGAGNSPSCFIKPSLSLNSLPPQGPPDGSEMAQHRLRIDRPYNSLKKKRDTERELWRRSWGSGHSHSSCSLQSSTTNTGLGKDDFWAALQTNYNFIMDTNLLDSCREARGEIEGSVFRDDLEDDVNCCRKALFKPAQTHRFYGDPRLLRQWIKEMENRVARVPSVTETKRLSIEQLQKLAVEHGVSRSGKRVNDCLLGGSIYFRPGARTFLQSPLTRHVTPFGWWRSEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VLY6</accession>
    <name>A0A084VLY6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP012674-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006549</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VLY6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006549-RA">
        <property type="protein sequence ID" value="ASIC006549-PA"/>
        <property type="gene ID" value="ASIC006549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006549"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS009501"/>
    <dbReference type="OMA" id="FHISAID"/>
    <dbReference type="OrthoDB" id="7719671at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006549-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="249" mass="29375" checksum="EADC520E2FBEEAAF" modified="2014-10-29" version="1">MLTTTTSDDHFRTSPDKRWKHYTGHAYEATGCPRNSAILNQCIEKSIQYYLSYMYSGSISDRTAVPSLDPLVLPDTTLIQNEHVLSTFTNRETTGFRNMYITDVRSDITRLEFYFQFHISAIDTKGSYHARLAKRPEIAEWSHMTYSIRNSSFELQLKGVNYEQDNRVYLKVNVTDWGQHIGDHTVGFRWFTMSGNYSQFSDQFEQIRGRDILPVVERDLMQSLRERFQHLFNEILRLAPFERFFPTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMM5</accession>
    <name>A0A084VMM5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Translation elongation factor Ts</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006561</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014607">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMM5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006561-RA">
        <property type="protein sequence ID" value="ASIC006561-PA"/>
        <property type="gene ID" value="ASIC006561"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006561"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006561-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="83" mass="8815" checksum="B7CDD51C9D21AD30" modified="2014-10-29" version="1">MSPLRKPTETTMPNKIAKTRDFDCGHASALISPTDFVAEECVYPRKGQTDIGSVGMAPGKASESNAVGCTPNRSQSVEFIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMN1</accession>
    <name>A0A084VMN1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP008746-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00006567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014613">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMN1"/>
    <dbReference type="STRING" id="74873.A0A084VMN1"/>
    <dbReference type="ESTHER" id="anoga-q7q887">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="ASIC006567-RA">
        <property type="protein sequence ID" value="ASIC006567-PA"/>
        <property type="gene ID" value="ASIC006567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006567"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004185"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="115"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006567-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="341" mass="38115" checksum="208C6E81BE3C7D68" modified="2014-10-29" version="1">MPFRDWRIVRVLSGIAMRIWAASGAALITAFLIYIVYGGLFTFLLLLFAVSGILYHAQDNLLYHPELPANSRIFIPVPSMHGLPYETLHLKTRDAISLHAFWIRHPGEKGRYVPTIIYFHGNAGNMGHRLQNASGFFHTLQCNVLMVEYRGYGLSTGTPSEKGFFADARTVLDHLFTRHDLDHGQIIVFGRSLGGAVTIDLAADAVYGSKLMGVIVENTFTSIPDMAVELIHPCVKYLPLLLYRNQFLSIDKIQFVSAPILFISGLADTLVPPRMMTMLHTRCGSIRKQMLQIAGGSHNDTWAVSGYYQGVAQFLKECRETKGPLQTAPVSHNVWPQIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VMT1</accession>
    <name>A0A084VMT1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006626</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524975">
        <property type="protein sequence ID" value="KFB39275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VMT1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006626-RA">
        <property type="protein sequence ID" value="ASIC006626-PA"/>
        <property type="gene ID" value="ASIC006626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006626"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002710"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783591" evidence="1">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006626-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="186" mass="21524" checksum="CB303F52F76E4756" modified="2014-10-29" version="1">MNLFRVLCRVFFFVGISIFSQSFRLVKSQSTSCYEISNGQRFLRPSSAVDPNRNYWRFAELTLNGTVETPWKLLPTLNSCFRLCNPETGLYLMVAENDFTYAVARDLMQQQPREAFIFGPYYPQWPNSLDALITSTLKLHQLCVFLDDDPNEDKLIVTYPQQTASAHPTQCRWQLRTVACPRSDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VN17</accession>
    <name>A0A084VN17_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP004754-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00006784</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524978">
        <property type="protein sequence ID" value="KFB39361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VN17"/>
    <dbReference type="STRING" id="74873.A0A084VN17"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006784-RA">
        <property type="protein sequence ID" value="ASIC006784-PA"/>
        <property type="gene ID" value="ASIC006784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006784"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018673"/>
    <dbReference type="OrthoDB" id="6097640at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB39361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006784-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="174" mass="20098" checksum="197F6D0A246BF5F8" modified="2014-10-29" version="1">MLSLDMVLRIESLAADETTRHKLMFEKITRRGPKAFNTLLDICQRNFPKAYAELNPSSNNEQMHSTLNTNRIREEQSDLGSYRLSTNTERDGMIDPRKPLPSNIATFRDMLVCYATVPSFAAHRGPEYWIMVRRSMCRVCNRANKLMLEKTCFTLEPAHEAWMVVAAVANRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VNC1</accession>
    <name>A0A084VNC1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00006958</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01014736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524984">
        <property type="protein sequence ID" value="KFB39465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VNC1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC006958-RA">
        <property type="protein sequence ID" value="ASIC006958-PA"/>
        <property type="gene ID" value="ASIC006958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC006958"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB39465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC006958-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6281" checksum="58F1DB18E61700B1" modified="2014-10-29" version="1">MCSYNVARNDDPDGGRPRAKLQAEDPPMLVRAFDNNVFASIRCGCVDTSMAPAKEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPE7</accession>
    <name>A0A084VPE7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP009518-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00007212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE524999">
        <property type="protein sequence ID" value="KFB39841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPE7"/>
    <dbReference type="STRING" id="74873.A0A084VPE7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007212-RA">
        <property type="protein sequence ID" value="ASIC007212-PA"/>
        <property type="gene ID" value="ASIC007212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007212"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000858"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007166"/>
    <dbReference type="OMA" id="PNITWHF"/>
    <dbReference type="OrthoDB" id="9355041at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="140"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="333"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB39841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007212-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="486" mass="54104" checksum="F48DE63EDA0EFA90" modified="2014-10-29" version="1">MIHDASVNDVRWVEGKCFISQEELLFVTTSINGNQPKTVPVVETLTLMPEEEMAHFVNQSRMVSCSFTNPEVKLKWRNPKNVLITDTKGRVHIEEKGSTLSLVFEMIARSDEGSWTCEVDTEGVSVAPLKKSFKMIVYEPISFRDTKTVQTAVEDKDATIRCEVKGHPEPSVSWNFNGQPLFFTNNGRYTKLADGMSIRKVVQSDSGEYTCKAFQVAATGSSFEEKTIRLNIKHKPYLPPWKTSVSDAYAYVGGMVNLTCEATAEPPANFSWSANNKKLTPKSHIIHTGRHVSMLQILIKTSSLFGKYKCEAKNELGSVSQEIHLKEGSKPDPPSLFQLRGVNSDTLDIDVGATKSHDIPPDPTTVIGYRFELLPTDEYMKSRSWDQASRRDFDVADGATYLLVQLIPDTKYLIRVAARNAAGLSDWTEVKEFSTHPLQPHGTSGSSGSHLPSDVCFKFLWLLAVGTAFPAALSITHHRFADMMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VPW9</accession>
    <name>A0A084VPW9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP006405-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00007492</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525001">
        <property type="protein sequence ID" value="KFB40013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VPW9"/>
    <dbReference type="STRING" id="74873.A0A084VPW9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007492-RA">
        <property type="protein sequence ID" value="ASIC007492-PA"/>
        <property type="gene ID" value="ASIC007492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007492"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS013595"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF531">
        <property type="entry name" value="DERAILED 2, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007492-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="124" mass="13870" checksum="EDDB28FC4BAE4DB1" modified="2014-10-29" version="1">MPICPSAYLQSCREIGIQNSQLSTRQLVEFGLQVTRGISHLHSLGVLHKDIATRNCVLDIELNVRVCDNALSRDVFPNDYHCLGDNENRPQRYGPAVEALRFPPTRKSAYKSSTFGQSLGLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQF6</accession>
    <name>A0A084VQF6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AGAP000243-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00007574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RHPN family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015202">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015203">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01015204">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525003">
        <property type="protein sequence ID" value="KFB40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQF6"/>
    <dbReference type="STRING" id="74873.A0A084VQF6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007574-RA">
        <property type="protein sequence ID" value="ASIC007574-PA"/>
        <property type="gene ID" value="ASIC007574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007574"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS002896"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007797"/>
    <dbReference type="OMA" id="PPVHDYM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11633">
        <property type="entry name" value="HR1_Rhophilin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="7">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="529"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007574-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="697" mass="77685" checksum="D6154CFE19577D7C" modified="2014-10-29" version="1">MEMKGVSPSAQGSDPRAATCRGKLQSKRCKLNQEINKELRLRAGAENLYKATTNKKLKDTVALELSFVNSNLQLLKEQLSELNSSVEIYQSEGLDYVIPMIPLGLKETKEVNFMEPFSDFILEHYSENSHTYEDAIADITDTRQAAKTPTRDAQGVSLLFRYYNLLYYVERRFFPPDRSLGVYFEWYDSLTGVPSCQRTVAFEKACILFNLAAIYTQIGAKQDRSSEKGLDAAVDNFLRAAGVFRHIFDTFTNAPSMDLKPQVLEVLVALMLAQARECLYEKLLLQLENYGDGPDNVQYREIHRIIHSNDAHTYLPECWAGLVPLKSEYYKVKCQLSEISTKLKQPTRTRVRDDAKSVGPGRCGGEDARQRYALPKDTFIFDEASLESDLEPSAVRQAHLRESLASHEEAQRLQRMCRELKNKIALTKVLNYAHERTSEELEELELERSCALGPADAGLDESDLDLLDVTLNATSKFTITLTGPDFTAHKIEDPFRRLGPIAIFSARRHWTAPRSVRLQKGSAALMLGALKLQDDAADQLPHQAGDSDVASFGFNIRGDAPVMVSTVDINSLADLGGIKEGDYIVEMCGVDVKWYTLQQVLKLIRTCGNSLELKVITPMDRNYLKPMALSHCSKGSVSTLSGSSSGISSGAPSPTGTTTKSLVKSSRSKLGSKTRLSSFTSGSWNPFRRTQSLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VQX1</accession>
    <name>A0A084VQX1_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00007748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01015338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525006">
        <property type="protein sequence ID" value="KFB40365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VQX1"/>
    <dbReference type="STRING" id="74873.A0A084VQX1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007748-RA">
        <property type="protein sequence ID" value="ASIC007748-PA"/>
        <property type="gene ID" value="ASIC007748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007748"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015674"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS018909"/>
    <dbReference type="OMA" id="PRYRATK"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000008">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Enkurin" evidence="11">
        <location>
            <begin position="392"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB40365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007748-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="495" mass="57017" checksum="D65C62F472FD9EE9" modified="2014-10-29" version="1">MASQAVNKTGSGWPRRNSHGTGLTEMNKLQTNQSMTLNRTINLYPLTNYTFGTKEPLFEKDPSVPARFQRMRDEFEKIGMRRSVEGVLLVHEHGLPHVLLLQLGTTFFKLPGGELTAGEDEVDGLKRLLTETLGRQDGVKQDWIVEDTIGNWWRPNFEPPQYPYIPPHITKPKEHKRLFLVQLHEKALFAVPKNYKLVAAPLFELYDNSQGYGPIISSLPQALCRGSVRSAVMSIVNIYFHDENIYNVEKKPPEKPPKPPLYHSRFEHQVRQETKSSKDAHRTMGFSKIPLQTPSEFLKKNCGPRYRATKSAPVRLCTGHKPPVPKPNETAGGQPMKMVDFKKENIKKVVTASPKKVRPRYADTRKGDFHDLEKSGLMPIYMCKPKFGKVPQYLTRRKKDLTAQKERLIEEQAQQKPRCSYISQEERVDLLRGLKQNWEKLQQEYQSLPLLTDTVPKMIRKAKLESTLKQLEKDILTIENNPYIYIYDEEQKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VR47</accession>
    <name>A0A084VR47_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00007920</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525014">
        <property type="protein sequence ID" value="KFB40441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VR47"/>
    <dbReference type="EnsemblMetazoa" id="ASIC007920-RA">
        <property type="protein sequence ID" value="ASIC007920-PA"/>
        <property type="gene ID" value="ASIC007920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC007920"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB40441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC007920-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="78" mass="8777" checksum="72D450790A475B41" modified="2014-10-29" version="1">MSPRRRPTVRISKHFLAQNPTTFTFLRAVVLAETMSSDPVVHRSLPFAHDTIYCAAVSSKFSVQTKAIRADEGKAHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSG1</accession>
    <name>A0A084VSG1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00008454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01015954">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525048">
        <property type="protein sequence ID" value="KFB40905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSG1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008454-RA">
        <property type="protein sequence ID" value="ASIC008454-PA"/>
        <property type="gene ID" value="ASIC008454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008454"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB40905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="76" mass="8156" checksum="2EE04FB274FEDB79" modified="2014-10-29" version="1">MKINLLEQPRELLSLVVLPASLETFPSGTASQGAKPFAKQKPPKAPKKETNGDSLCSLDIEKTQTIVGSKHSIPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VSZ1</accession>
    <name>A0A084VSZ1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Lipoxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00008541</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01016151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525057">
        <property type="protein sequence ID" value="KFB41085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VSZ1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC008541-RA">
        <property type="protein sequence ID" value="ASIC008541-PA"/>
        <property type="gene ID" value="ASIC008541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC008541"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB41085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC008541-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="127" mass="13575" checksum="C60340EFA7278452" modified="2014-10-29" version="1">MSPTKSISAESRHSVHSPIGVRIICQPSITHETILALCRRVPETGGINTEERGVVEAHSNLCSDNDANYGPAPCARWVTGKSAKASSRFAPVPLPSDCERRGTGSGSVTARHALNRTIICDHSEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VV91</accession>
    <name>A0A084VV91_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009731</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VV91"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009731-RA">
        <property type="protein sequence ID" value="ASIC009731-PA"/>
        <property type="gene ID" value="ASIC009731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009731"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009731-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="149" mass="16667" checksum="195F3077FC11AA0D" modified="2014-10-29" version="1">MPVDRAPAELHPGNTQHNWRSSNVALGPEAPHGQRRRAGRRSAYTHEHTRARARTIKGLEGEPLEPIDRNALTVTLSGTAPREQLLRMLGTRSGLRSLSSRPTRKGPTTIAVSATVWALWALGGQPVDHLTYYFTHFNLKNCQRYQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVB7</accession>
    <name>A0A084VVB7_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ZHAS_00009472</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ATLV01017170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB41911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVB7"/>
    <dbReference type="STRING" id="74873.A0A084VVB7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009472-RA">
        <property type="protein sequence ID" value="ASIC009472-PA"/>
        <property type="gene ID" value="ASIC009472"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009472"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS004107"/>
    <dbReference type="OMA" id="MDCVETI"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05646">
        <property type="entry name" value="M20_AcylaseI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000005">
        <property type="entry name" value="Putative Aminoacylase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="196"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KFB41911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009472-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="409" mass="46492" checksum="94D5C969018393AD" modified="2014-10-29" version="1">MCEADAECSKKFQEWESNEEIQIFREYLRIPTVHPNVNYDECVAFLKRQAASLDLPVRVIEVNPGKPIVVISWEGTEPEQKSIILNSHMDVVPVYEERWQHPPFAAEMDHQGRIYARGAQDMKCVGMQFLAAIRALRRDGVRLKRTIHATFVPDEEIGGKLGMMEWVHKESFRELNAGFSIDEGIAGEGEVYPLFYGERSVWHVYFNFSGTPGHGSLLLKGTAGQKAHYIIDKLMRFRENEVQRLENNPEFTIGDVTTVNITIMKGGVQENVVPPELTVCFDMRLAVDVNHLEFENQLLDWCREAGGGIELEYDQKCPYVKPTKLDSSNIYWVAFKDALDELGLKVKPQIFPGGTDSRYIRGIGIPAIGFSPMNNTPVLLHDHDEFLKADTYLEGIRIYRKIIANVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVM3</accession>
    <name>A0A084VVM3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Octopamine receptor oamb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ZHAS_00009596</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVM3"/>
    <dbReference type="STRING" id="74873.A0A084VVM3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009596-RA">
        <property type="protein sequence ID" value="ASIC009596-PA"/>
        <property type="gene ID" value="ASIC009596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009596"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007010"/>
    <dbReference type="OMA" id="GTKQVMM"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004935">
        <property type="term" value="F:adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15067">
        <property type="entry name" value="7tmA_Dop1R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000282">
        <property type="entry name" value="Dopamine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="78"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KFB42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009596-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="523" mass="59117" checksum="88F2D72A463BBE36" modified="2014-10-29" version="1">MMNNASELYWELSQLIGLSNLTFYNVSSEGVVATGTVTLAVNCCTTEPNFSNYLESLPNDRAGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFVTSLAVADCLVGLVVMPFSALYEVLQNTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMKMTRRKAVALIAAVWICSSAISFPAIVWWRAAREGDMPPFKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAAIQTRSLKLGTKQVLMASGELQLTLRIHRGGTTRERPNHPRLLPSAAIEQQQQQLQQDKQQQSAQQLLVTQQQSPIGGNSGAGSQQPHQSQLHQQQQQHQQHTANSTPEDPDDEPLSALQNNGLGGRHRTHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIVCWLPFFVVNLLSGFCMHCIAHEEIVSAVVTWLGWINSSMNPVIYACWSRDFRRAFVRILCVCCPRKIRRKYQPTMRSKASQRFASRRCYSTCSLHGIQQVRQNSCEQTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVQ6</accession>
    <name>A0A084VVQ6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Ferric reductase like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00009632</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525157">
        <property type="protein sequence ID" value="KFB42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVQ6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009632-RA">
        <property type="protein sequence ID" value="ASIC009632-PA"/>
        <property type="gene ID" value="ASIC009632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009632"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006630"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009632-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="127" mass="13991" checksum="B4D25348D3524EB8" modified="2014-10-29" version="1">MKSSGTRDAQAYLRLFFTKGKVLESVVTLRVLECTSNTVPRRDPPHPKPEPGLCHATKNHARSVCDGISMAEEGAVRVGFCFLNNAGTVERRNCDECLTYGFGTEEVLINGTSGAYFVTRAVFRWAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VVU2</accession>
    <name>A0A084VVU2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00009745</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525161">
        <property type="protein sequence ID" value="KFB42086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VVU2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC009745-RA">
        <property type="protein sequence ID" value="ASIC009745-PA"/>
        <property type="gene ID" value="ASIC009745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC009745"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022958"/>
    <dbReference type="OrthoDB" id="10608399at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB42086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC009745-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="138" mass="15162" checksum="7A64A77F9B5CC1A2" modified="2014-10-29" version="1">MDIGVSNGMKSDEDPSNVLCPADDGSYIIQPKIPEPEQNHQRPSLTALDASPIDDQSVETPTRNATIFRLQKCSTKIFGLSPVSELSAALHCTGLDTPRLSRADRSVLASKRKVWFEQLDAGQDENARARARSQLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VWU6</accession>
    <name>A0A084VWU6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP010123-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00010140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01017755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525185">
        <property type="protein sequence ID" value="KFB42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VWU6"/>
    <dbReference type="STRING" id="74873.A0A084VWU6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010140-RA">
        <property type="protein sequence ID" value="ASIC010140-PA"/>
        <property type="gene ID" value="ASIC010140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010140"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022200"/>
    <dbReference type="OMA" id="DDHNAQY"/>
    <dbReference type="OrthoDB" id="7789829at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF46">
        <property type="entry name" value="CUTICULAR PROTEIN 30B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783894" evidence="3">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010140-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="21683" checksum="51A92A2CBADFF020" modified="2014-10-29" version="1">MAFKFVALFALLAVASAGVIPIEEVHSAYQPATYSAHLAPQPTLIKTVAQPTIVKTIAQPTIVKTIAQPTLVKHLDEDHDAHYDFSYGVHDDHTGDIKEQRESRQGDQVHGQYSLIDSDGHKRTVEYTADDHNGFNAVVHREPTDIKIPQPQAVHKIIAQPAITKVIAQPTKIIAAQPTYYQQPAQAVIKTVGLSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXA4</accession>
    <name>A0A084VXA4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Muscle-specific actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ZHAS_00010309</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01017896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01017897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525196">
        <property type="protein sequence ID" value="KFB42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084VXA4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010309-RA">
        <property type="protein sequence ID" value="ASIC010309-PA"/>
        <property type="gene ID" value="ASIC010309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010309"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003014"/>
    <dbReference type="OMA" id="TETEMMS"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KFB42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010309-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="192" mass="20785" checksum="555ABFC01A74251E" modified="2014-10-29" version="1">MCDDDAAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAXXXXXXXRPCGSPSRSTTSPARESSTASASKRHGALGESVCGVLTNVSATNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VXK3</accession>
    <name>A0A084VXK3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005283-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00010435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525212">
        <property type="protein sequence ID" value="KFB42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VXK3"/>
    <dbReference type="STRING" id="74873.A0A084VXK3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010435-RA">
        <property type="protein sequence ID" value="ASIC010435-PA"/>
        <property type="gene ID" value="ASIC010435"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010435"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017347"/>
    <dbReference type="OMA" id="ENIYAME"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001783989" evidence="1">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010435-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="306" mass="35722" checksum="867F79E1FED11401" modified="2014-10-29" version="1">MQVTIVLLLSVRTVLATVILSRAKHYEEMRAAIVGAEQDYGTGGKVFLNPDEQHVDRVLREMKKRELHPPENGLLPAGMHFFDARSLIEDSPVFRTLKSMPKGAVLHLHNSAAVSSRWVISNLTYRDEARLCQQDDRYYFTVRPHGRCPENQTHRITDMRKGHKEGVEAFDRWLESIINLKHKPTAKMSRLATVNELWVDFESCFDAIKGFLHYKPFYEAYHWQLLREFHDDGVLYIEFRISLGKVYDEGGKEYGPPEITSMLRRIVDEFRRQHPSFHGVKIIMAKHKNMNDEELENALKLYDNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VY22</accession>
    <name>A0A084VY22_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010620</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525226">
        <property type="protein sequence ID" value="KFB42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VY22"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010620-RA">
        <property type="protein sequence ID" value="ASIC010620-PA"/>
        <property type="gene ID" value="ASIC010620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010620"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010620-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="11777" checksum="BB5CD8D9D24BE5FE" modified="2014-10-29" version="1">MEQNRTHQNLVSEWADGLKVQVVGAQSDTQSFGTGSSVVFHTGKRLSLACRGAKEHWLNGADSAPDIAIHLVPLDQWKISVRLWSMSVRTPHMGQVSPVYPAIGNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VYK9</accession>
    <name>A0A084VYK9_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Homeodomain-interacting protein kinase 3-like isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00010729</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018377">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525231">
        <property type="protein sequence ID" value="KFB43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VYK9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC010729-RA">
        <property type="protein sequence ID" value="ASIC010729-PA"/>
        <property type="gene ID" value="ASIC010729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC010729"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC010729-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="80" mass="8620" checksum="35B6CC01FC48C17B" modified="2014-10-29" version="1">MVGSGMARNKISNSRPMSLVIIITIRSIIITCEAPDSIITATASTTTTGEWQRHHLRLANDRCSSTGNSISFDRVASLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084VZ30</accession>
    <name>A0A084VZ30_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Malto-oligosyltrehalose trehalohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011000</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01018591">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525239">
        <property type="protein sequence ID" value="KFB43224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084VZ30"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011000-RA">
        <property type="protein sequence ID" value="ASIC011000-PA"/>
        <property type="gene ID" value="ASIC011000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011000"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011000-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="64" mass="6876" checksum="82B21D055059CF68" modified="2014-10-29" version="1">MMDFPGKYLGDMATLATSTPPAENRFAPKESDVAKDRFDNLRPKAELTILPPATVRPSTPASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0F4</accession>
    <name>A0A084W0F4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011429</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525262">
        <property type="protein sequence ID" value="KFB43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0F4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011429-RA">
        <property type="protein sequence ID" value="ASIC011429-PA"/>
        <property type="gene ID" value="ASIC011429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011429"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011429-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="107" mass="12389" checksum="4D5236BEB0BBDD62" modified="2014-10-29" version="1">MCPLKRCESPRSATVLACDDLFRLVIGLRRSTNIQTACSVRGREWSVRGWRATDMAVSMPGRRPIGATPSFINQFRLSRTDRAHQQSQYQHRPGTEIRKSRQYIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0S2</accession>
    <name>A0A084W0S2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Putative 5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00011659</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0S2"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011659-RA">
        <property type="protein sequence ID" value="ASIC011659-PA"/>
        <property type="gene ID" value="ASIC011659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011659"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011659-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="179" mass="19748" checksum="88E7E3F8EA55D2EC" modified="2014-10-29" version="1">MPAIRLTVLRSRDGGEHFHKGSTASIIPTDYNFRSGRLSGGRLANSRTSRTVPTKFGLAHPDLANINNDDLAHVFSSVFCFALHAFKPADRKLVLIMYAPGGGLVNYPANSPQNRPQHHPSVLSRLPRAEMRQTSADISKDTSASRVVPSRQSGAPQFRTQLKFTGSGWRPLKFVDRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W0Y7</accession>
    <name>A0A084W0Y7_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">MCG140471</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00011615</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01019165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525263">
        <property type="protein sequence ID" value="KFB43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W0Y7"/>
    <dbReference type="EnsemblMetazoa" id="ASIC011615-RA">
        <property type="protein sequence ID" value="ASIC011615-PA"/>
        <property type="gene ID" value="ASIC011615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC011615"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS021145"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011615-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="91" mass="9786" checksum="982BF29DFD8D90B6" modified="2014-10-29" version="1">MSGLDCGVATLVGSINAISTLDVKAGRVHHGETCIPLRTNNVTNVCNYKLLYLPILEYPLVGISNLTFGGSYADRKPSESFSFKNSSFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W118</accession>
    <name>A0A084W118_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AGAP002210-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ZHAS_00011736</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01019199">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01019201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525264">
        <property type="protein sequence ID" value="KFB43912.1"/>
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        <property type="gene ID" value="ASIC011736"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC011736"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015677"/>
    <dbReference type="OMA" id="MVCGSTF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="14" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784336" evidence="14">
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            <begin position="22"/>
            <end position="437"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001971"/>
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            <dbReference type="ARBA" id="ARBA00003690"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC011736-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="437" mass="50448" checksum="76420D2FD20DA018" modified="2014-10-29" version="1">MELFLLSLVIVLLVTLYKKYQQMFEFSEKIELHESYIPILGHVPKVIGKSREQLHRLLRDVFLSHDRLFQVRLLWKMFVCTSHPDIMRAVMDNPKTMNKLKEYAFMKLDQGLLVSPYSLWKHQRKTLNLSFNKRILENYLPLFDKCVGRMIERMRMAPNFKQVDVMEICTRCTLDMVCGSTFGTDSLDDPKAAKLFEVIDDGLDAIAQRVINVQYHPDFIYRFTKLNKNLNQLLKEMSAYVANILNVQRSSQKVNRAKETNSDDEIEYRKPQIFVHQLLKSTRGGEPFSDEEILHHAMTMLIAGNDTTAISICNHLTLLAMHPMVQEKVRSEILSVFPAGCEQETTLEALNQLIFLEQCINEALRLCPPASIVGRSSSEDVEVEGILIPRGTNFVFNIAALHRRKDFWGPDADLFDPDRFSPERSKGRHPNAFAHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3L6</accession>
    <name>A0A084W3L6_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012719</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020057">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC012719-PA"/>
        <property type="gene ID" value="ASIC012719"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012719-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="58" mass="6075" checksum="3F4AD9A51B8FF8E6" modified="2014-10-29" version="1">MFPKPAYGRPFSTTIATSRQTPALTSGGAHCLPKTAGAADDAKPSPATVGEQSWVEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3N6</accession>
    <name>A0A084W3N6_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00012741</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ASIC012741-PA"/>
        <property type="gene ID" value="ASIC012741"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012741-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="53" mass="5573" checksum="F2B2BEBABE73BB80" modified="2014-10-29" version="1">MGERGPPEGWHEKKDFRGGKDHVITTGGGVVSLLNGISGCRNGRVLSRGTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W3P4</accession>
    <name>A0A084W3P4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP011197-PA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00012750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525293">
        <property type="protein sequence ID" value="KFB44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W3P4"/>
    <dbReference type="STRING" id="74873.A0A084W3P4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012750-RA">
        <property type="protein sequence ID" value="ASIC012750-PA"/>
        <property type="gene ID" value="ASIC012750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012750"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS016696"/>
    <dbReference type="OMA" id="NCAVTHE"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012750-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="317" mass="36878" checksum="F9FDA0D2BCBB12AF" modified="2014-10-29" version="1">MRINRPQGMTAGYEMLSAKLDFLQNKLLEMELGIKERDEQITEKQDQFEKVIGTNLTALQTDSWKILAQQSACASHELMRKEIEQIAPKDGVSKNTQSLRTLEGLYRKGPFQSCMDAPAKESGVYSIKVGGNKELLKGFCEQNSFGGGWLVIQYRFDGSLDFYRNWTEYRNGFGNVYQEFWIGLEWLHQLTSQSSYELMVEIKDFDGNYRYAHYSEFEIGSELEQYHLKTLGAYDGTAGNSLIYHAGMKFTTKDRDNDNNESNCAVTHEWAWWYKSCLHAHLNGKYMNKENSHAIGWYHYRRNREGLAYSRMMIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4A4</accession>
    <name>A0A084W4A4_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="6">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAN3</name>
        <name evidence="9" type="ORF">ZHAS_00012991</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525297">
        <property type="protein sequence ID" value="KFB45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4A4"/>
    <dbReference type="STRING" id="74873.A0A084W4A4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC012991-RA">
        <property type="protein sequence ID" value="ASIC012991-PA"/>
        <property type="gene ID" value="ASIC012991"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC012991"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS007626"/>
    <dbReference type="OMA" id="ASHVINM"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000451">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="275"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="6">
        <location>
            <begin position="572"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="429"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KFB45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC012991-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="669" mass="73498" checksum="37A14BEF4003DD81" modified="2014-10-29" version="1">MDPMFFPPSNGVPSESKLATYMVTPQSPEFIPNNRLSSSSSPNFYSSYSILSNSNNGAGSSTVVGSNGTVVATQQPAPPTALSTVVGKGAVVAGGGGGVGYAVGGNSILAGPLGSSTSAFAVTPNKGRNLLRNESPQSTNTSPRITPQPSPPPITTNIHQENVGGTTYFYPTAANHQLPSSSTVNTTDNSFVHIASSQINLSYTHPGHIYPGPASHVINMQSKVQVSAAFFMQDELRNDILARNEIVNSIDNDCPDIPLEVENYHSLCLLESLPLHPKLPLPSSTYKATHSVTGVKYCLRRLHGFRLQSTKCMQVVDMWKKLQHSNIVQLREVFTTKTFGDNSLVIVYDFHPGSQTLLSKYFTSVPETNGYTDPFAGEARPFSHKSSMHRTSATSLLPENEIWSIIMQLSAGLRAMHQAGLACRTLDPTKIIVTGKRIRYSCVGISDIATFDPNQQNPLTVVNHHQQEDLTALGKLILALACRSLQSVQRDQIQNSIELVSRHYSQDLRNIILCLLNPTARRSVTEIMPMIGARFFVQLDALQTQCDIQEDELAKEMENGRLYRLLVKLGCINERPELNLDVTWSETGDRYMLKLFRDYLFHTVTEDGRPWLNQSHIVQCLNKLDAGTMEKVQLMSRDEQSVLVVTYAELKHCLDQAFSELVAASDGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4M5</accession>
    <name>A0A084W4M5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525299">
        <property type="protein sequence ID" value="KFB45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W4M5"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013127-RA">
        <property type="protein sequence ID" value="ASIC013127-PA"/>
        <property type="gene ID" value="ASIC013127"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013127"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013127-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="221" mass="24643" checksum="C2DD5B424147F191" modified="2014-10-29" version="1">MATFVPGSQRCQAEAARRRRSSRGVSRIQASTGLGLACGRLTKRPQPSCSAKKSLRIANKKMKVRGTVSQLEKLRNVNGYVSVGPVRLAGLLVASGDVPAIPREGYTTPAAWLRLTGLGGKMEVPEEGDRAGIVFRFYRARHDVQRPSCCRPNGNRKLTTHHGFFVAVPCMWEGVEEREIKRRWEERNITLCPSRWSIVCVRAGTFLFGQCATEKGFFYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Y3</accession>
    <name>A0A084W4Y3_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00013258</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
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    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525302">
        <property type="protein sequence ID" value="KFB45277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="74873.A0A084W4Y3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013258-RA">
        <property type="protein sequence ID" value="ASIC013258-PA"/>
        <property type="gene ID" value="ASIC013258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013258"/>
    <dbReference type="OMA" id="HMYHHIP"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16474">
        <property type="entry name" value="RING-H2_RNF111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000479">
        <property type="entry name" value="E3 ubiquitin-protein ligase Arkadia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1578"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="164"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="943"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1313"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1447"/>
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        <location>
            <begin position="286"/>
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        </location>
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            <begin position="379"/>
            <end position="388"/>
        </location>
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            <begin position="564"/>
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            <begin position="588"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
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        </location>
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        </location>
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        </source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB45277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013258-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W4Y5</accession>
    <name>A0A084W4Y5_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP003120-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01020424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB45279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="ASIC013280-RA">
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        <property type="gene ID" value="ASIC013280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013280"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS015801"/>
    <dbReference type="OMA" id="KQPVPME"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05217">
        <property type="entry name" value="SAXO1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KFB45279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013280-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="571" mass="62848" checksum="5558A4E3AB6CEBB8" modified="2014-10-29" version="1">MECDGVGAAEQFLAKDTTACYDEGVPLAPQVPCSPITQPEPEPDQCDELCVDLQTCSQPCVEPGPTVVDQCTAEMPQCCNCACGRPGCVPTKRVRYVQPPKRESCKPIATYKAPEVQFAGDSVYKTSYNPDPQLVVNARPLPIKPQSHLVPNPGCVENTTVTTLSYPGYNNIERAQPIVPVGNQLIQSGPLQEVTTNRHDYVAKTTPKRYKIVPAGHMHVHSAPFEKQTVNKLSYSCPNMASFEPARSCKPLREYERPEIPMQSDTTTKLSYGPICPPPKEDVPWARRACYQPPNVAMDNETTYKKSYMSSHCANERAKMVLPYNNLAVPAGSGFESKTVYKDSYHSAPCGERPPAIRPVVQLRVPNTKLEDDTVYKTSFATHCNAERPTPILPRPAPLIGDGPMQEMTTQRHDFVCKGHAKRDPIVPQGSLAIPSGRLESATSNRLSFPANKENMVPTKSCKPVRVYKRPEEPMESDTTQKLSYMPVCPPPKEHYPWAQRVRFQAPNQPMESDTVQKLSYPPPGQYIEESCPSAGGLPCCQSCNPAAVNCCGNMETSCTGVSYPRAGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W5L8</accession>
    <name>A0A084W5L8_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="1">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="1"/>
    <dbReference type="EMBL" id="ATLV01020673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525304">
        <property type="protein sequence ID" value="KFB45512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W5L8"/>
    <dbReference type="STRING" id="74873.A0A084W5L8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013454-RA">
        <property type="protein sequence ID" value="ASIC013454-PA"/>
        <property type="gene ID" value="ASIC013454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013454"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS000354"/>
    <dbReference type="OMA" id="HYHEAHE"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB45512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013454-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="148" mass="16445" checksum="11DD114C7C5A0EC2" modified="2014-10-29" version="1">MEHHGTENDVPPIKVTIVKGKEDICVKMSDQGGGIPRSQVDQLFKYMYSTAPQPPKSKTDLPLVPLAGYGYGLPISRLYARYFHGDLVLFSCEGYGSDAIIYLKAFSDEANELLPIFNKTSTRFYKATVPTGDWSNQVKGKKVKPIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6M3</accession>
    <name>A0A084W6M3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00013842</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6M3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013842-RA">
        <property type="protein sequence ID" value="ASIC013842-PA"/>
        <property type="gene ID" value="ASIC013842"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013842"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB45867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013842-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="77" mass="8687" checksum="9C63A97CA39284E3" modified="2014-10-29" version="1">MFGDRIKCANHFNVTDSSSARSGLPQDRLDICSPAFYTSTEEYACPASARKLKSIGTNECLLSTVVWKEHEHWYDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6Q6</accession>
    <name>A0A084W6Q6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Osmolarity sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013863</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525309">
        <property type="protein sequence ID" value="KFB45900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6Q6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013863-RA">
        <property type="protein sequence ID" value="ASIC013863-PA"/>
        <property type="gene ID" value="ASIC013863"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013863"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013863-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6904" checksum="93816731042ED2FE" modified="2014-10-29" version="1">MDQRVDLLRRRDRELWKAVEEGPAIGDGASTDRATEAERPKDGETKVKPIFGSPNANLLGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W6U4</accession>
    <name>A0A084W6U4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00013903</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01020949">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525310">
        <property type="protein sequence ID" value="KFB45938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W6U4"/>
    <dbReference type="STRING" id="74873.A0A084W6U4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013903-RA">
        <property type="protein sequence ID" value="ASIC013903-PA"/>
        <property type="gene ID" value="ASIC013903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013903"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS008295"/>
    <dbReference type="OMA" id="SEMTHHR"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="259"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
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            <begin position="433"/>
            <end position="456"/>
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        <location>
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            <begin position="529"/>
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            <begin position="588"/>
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        <location>
            <begin position="616"/>
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        <location>
            <begin position="654"/>
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        <location>
            <begin position="786"/>
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        <location>
            <begin position="820"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB45938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013903-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="1103" mass="119613" checksum="D9723BC2910DB832" modified="2014-10-29" version="1">MEATESETHLARSDKENNAGNAMRDEQSPFVAVKDEPGDSETDGSARNSDTQQKQKKKSKRSIMEQLRIDTVEGKTLDVMNLSRSRSTRRKSVPVRRVESEKKSRTAETKLVEKSVSAVKDARKNVQQQKDVRSSRKLLNFENIDAVDRNGSVGNTSDDVIESSQTPALSQSLVSKKMNLRRSRVEPESVDSSRPYSVENATEASVPLKATNSDTETNTVQSEAVTATEANDVSQVPPPVCEQMEVDPPSEDNAGTMEASEHQLDKAEEQTEEKTVETSKIKQTRTDSAWAENVPGEKKEPTVTPASPSRRSIRRASTDEPPASVGCPAAPKSPKDKKNSDTPDKGTPSKMKITCRDFPVRVALQLLNSPKKNLEDEMGHTIAENCTGLSSPKVARYSPLVVLEPMKEYPVVVKGADVAETVADKAVGLSEQVDSTGSVGVDGSEQNSKDGQTTGSDDPLSPVKNLDEEMEPLNKSLNRSIVSSPDLADAEERNADLMNSTLNISPIAEHKDEGAPKGTDDGGVLAGSADRRSSSRVLGKERESSVTFTPIPMSTMSRRNRPSPSPQLPHAGPGQTGNASGMKAPLRPQQNQGTPRSPSTHMINLGGRGAQLINLIRQSPNPNTPPQNASTPKGAGPSVASANRLMMRKKAIEASASASATVELGSAAAAPPSSASKQGEENSDTSQYLVFSKVLPSPQASPAISILKRRHNVDDSGDDIESPINKRKRVSFHDPPVSATKEYIRQAEECRSPSISRCLQLATSMSSADKAKYMMRRRGKSDSISELKNYTNKQGEQQSGESSATNVVGTGEGGPSADANGEEEEDEELTSSPESLDESQFMIHDATDNMDPLQVTVELMDVGQSSEEHKSSVSASEGCTDEPKAAESPEKSSENELRFSSEEAILEHVMRRYALGDIVERYLAAGRTLEHGKPTTIRVLTKELSSVMSKDPKTRHLVLDELSERHSVEFLEHAIQENSSTMVCERLSLTAMTDHIFKQLRSGCRDSGATASTTSPPAHPDEKDNDGMQLVQRIYEKLHDLPIDMQSNGGQTLAMLRERFLARGIGAQISSGNDGFARGLFQSQRRTGVIGQCQWLFLNSEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W711</accession>
    <name>A0A084W711_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP002663-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00013973</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525312">
        <property type="protein sequence ID" value="KFB46005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W711"/>
    <dbReference type="STRING" id="74873.A0A084W711"/>
    <dbReference type="EnsemblMetazoa" id="ASIC013973-RA">
        <property type="protein sequence ID" value="ASIC013973-PA"/>
        <property type="gene ID" value="ASIC013973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC013973"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS006111"/>
    <dbReference type="OMA" id="WLQDEFF"/>
    <dbReference type="OrthoDB" id="7323052at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC013973-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="376" mass="42773" checksum="AB9BB3C339135397" modified="2014-10-29" version="1">MKDICHPDINRNRFHFFLPDCSHFHEHCVRCTDTSCIKCTEVLRVDTGECLLECPNGYVAQWSTNSELMGRVCHPVGLSGSLLAAVVGIVAGAIVCVVIVVAAMAVLRRRQKRKKYRESFIDENIDRLEFVRQLDELRPQAEYFLQMLNDTRRQIRKLHLAGDSAGAATYHPVVRDLAKILILLNKPVELINAPPHDWQRLHVWAERVLDRYKPELAQLIEFLQQPSAPLSPSASDPRLGSSDHSTFKSAYHSANAPGHHETNESDLSPSLSQKNERNLLRPELIQLQKHRTLPTMQTTHHFLGSLISLHEFDERSSHTTDTSHHSMAGGNNPFDDTFDHVRTYLSTSGMNDSSLWLQDEFFKLGFRPQDEITTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W7E3</accession>
    <name>A0A084W7E3_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ZHAS_00014223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ATLV01021228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525315">
        <property type="protein sequence ID" value="KFB46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W7E3"/>
    <dbReference type="STRING" id="74873.A0A084W7E3"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014223-RA">
        <property type="protein sequence ID" value="ASIC014223-PA"/>
        <property type="gene ID" value="ASIC014223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014223"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS022947"/>
    <dbReference type="OrthoDB" id="8170061at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14799">
        <property type="entry name" value="FAM195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KFB46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014223-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="134" mass="15111" checksum="DFC01BF4366287B6" modified="2014-10-29" version="1">MQSGRDMPPQNHSPYQPKPNHVGPNAAGSMMNNSGNNGPPPSSSSVVHPMHPLQQNHQQLHPQPSQLQHSQHDELIRYINEAWHSITTDKSQKPPVFYKSVSEPRLPGFTPFDLEGWWGQRLVHQLNISSHGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W826</accession>
    <name>A0A084W826_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Scavenger receptor cysteine-rich type 1 protein M130-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014361</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525317">
        <property type="protein sequence ID" value="KFB46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W826"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014361-RA">
        <property type="protein sequence ID" value="ASIC014361-PA"/>
        <property type="gene ID" value="ASIC014361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014361"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014361-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="81" mass="9275" checksum="B5C06C54ADAF2C37" modified="2014-10-29" version="1">MMMTTTTTILWPNGEWSGGVVEGRSPGRDSARDGLAHVERREHDEDDRYPSSSLKDTGGYRKWQWDEGGGRGKRWCTMMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W8M6</accession>
    <name>A0A084W8M6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGAP009901-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014607</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525319">
        <property type="protein sequence ID" value="KFB46570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W8M6"/>
    <dbReference type="STRING" id="74873.A0A084W8M6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014607-RA">
        <property type="protein sequence ID" value="ASIC014607-PA"/>
        <property type="gene ID" value="ASIC014607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014607"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS010669"/>
    <dbReference type="OMA" id="PEESHCV"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014607-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="166" mass="18791" checksum="587E0C7A00101164" modified="2014-10-29" version="1">MVKEKPTPRLYDKDGYRRRAACICVRSEAEAENIEHKHRTEVFVMVVTKELEEWEDSKTIGRKRQWFSIEEALSQLALHKPTQRHYLQQLRHSKHRNSSSSEPPPIISEDGDDDFTSELETNNSTKANAVTSTTPTTPTANDDMVTSVTDCEPTTTTSSPPTTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W922</accession>
    <name>A0A084W922_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Insulin-like peptide 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ZHAS_00014715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W922"/>
    <dbReference type="STRING" id="74873.A0A084W922"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014715-RA">
        <property type="protein sequence ID" value="ASIC014715-PA"/>
        <property type="gene ID" value="ASIC014715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014715"/>
    <dbReference type="OMA" id="IWHTDCH"/>
    <dbReference type="OrthoDB" id="10044229at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04365">
        <property type="entry name" value="IlGF_relaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010759972" evidence="3">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KFB46716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014715-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="181" mass="20410" checksum="240923199D100793" modified="2014-10-29" version="1">MWFPLALCVLLEFAELVSGSSVGGGGGGGGGGVGLDDGQLEVTFSERTRADWEKVWHQESHSRCREKLIRHLYWACEKDIYRISRRSGSAGTDGMPEKRARDDGEEANALVVVPARQKTVSFPWAIDREVAYSFLRTRRTGKRRSGGSITAECCTRTGCTWEEYAEYCPSNKRLNHYRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W937</accession>
    <name>A0A084W937_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00014732</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525320">
        <property type="protein sequence ID" value="KFB46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W937"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014732-RA">
        <property type="protein sequence ID" value="ASIC014732-PA"/>
        <property type="gene ID" value="ASIC014732"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014732"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014732-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="63" mass="6685" checksum="C366633B91816951" modified="2014-10-29" version="1">MNVVVNPITSPSTIGTDVSIIFGCASGNINTGFIEVNLHTQRAAVIPQFQLATELFGTPKCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9D2</accession>
    <name>A0A084W9D2_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGAP002272-PC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ZHAS_00014828</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC014828"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIS017069"/>
    <dbReference type="OMA" id="MRNKTAF"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UPA_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <end position="838"/>
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            <begin position="839"/>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R2</accession>
    <name>A0A084W9R2_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ZHAS_00014970</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ASIC014970"/>
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    <dbReference type="VEuPathDB" id="VectorBase:ASIC014970"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS003964"/>
    <dbReference type="OMA" id="ICQSGMA"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
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        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784428" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KFB46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014970-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="197" mass="21888" checksum="EF104A531DDAED05" modified="2014-10-29" version="1">MHSKAITCLIGLSVLVIGAASFEQPCQGVRNGYFVRDKSNCAGYYYCNEGASILNLCPGDFYFNELTQMCDYPERVNCHICQQQTGVQVSAHPQNCNQFIVCSEGYSSIGQCIEGYAFDGRQRVCHPSSRVNCSSSRCPEQDNPNQIVYLPGVESCEEYFICQSGMAVQKLCAPGLFWDAINERCDFSQNVSCNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9R8</accession>
    <name>A0A084W9R8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP004783-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00014976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525324">
        <property type="protein sequence ID" value="KFB46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9R8"/>
    <dbReference type="STRING" id="74873.A0A084W9R8"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014976-RA">
        <property type="protein sequence ID" value="ASIC014976-PA"/>
        <property type="gene ID" value="ASIC014976"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014976"/>
    <dbReference type="OMA" id="DFCNLTY"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001784744" evidence="2">
        <location>
            <begin position="31"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KFB46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014976-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="342" mass="37311" checksum="3591C30BBA71CE20" modified="2014-10-29" version="1">MCRASSRPFRATLLLFHVSCISIGIAGVGAGTGVGDLTTRSGNEWRPPEPERWSPLASLADSSLTSLTGPLDPRPAQNQRPAVQEPPGDGGAGDTVPGTNTHPRTRMASSEPSVHQRPPSGWLKSFEGAEKHFLFRRDLSKTQDAPPRFAPPSDAIGWTWADNRTGSGPICHGSTESMDGSCNTSRGRAPGPVLMTKASNSNGTEDFPGSNRTAAPNNASAFLALGELELATLQSPLEEENHTAHYYTVVNLDNHNDVLCDDEYQMEYNENCFIDHNVTCVGDPDFCNLTYDEYRQLLMDYIYPSTGEWILIASHTVVFIMGLTSHRNIPLKYNDVNYATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084W9U1</accession>
    <name>A0A084W9U1_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AGAP002106-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ZHAS_00014994</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01021913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525325">
        <property type="protein sequence ID" value="KFB46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084W9U1"/>
    <dbReference type="STRING" id="74873.A0A084W9U1"/>
    <dbReference type="EnsemblMetazoa" id="ASIC014994-RA">
        <property type="protein sequence ID" value="ASIC014994-PA"/>
        <property type="gene ID" value="ASIC014994"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC014994"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS005226"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC014994-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="392" mass="42807" checksum="77B3AB32082C08FC" modified="2014-10-29" version="1">MEAEESYTDVENQKDAESASSVDDFSASEDEWIPDKLESPIAAKIVLTGKPSKKRAKKPTIPLKPARVSRRIAAKNGITLPEETEAEAKEQLSTIVASSSDSEDSDSEGEKKPPKKVKRKTARTKAPAKRKQRKKDQVEIDEEPIKLTTFTVEQLYRKYRPDLAHPLPQSDKPGPSKGLSSKRSDENGDNRDSESSGDDYLVDPSELDLDSEFFRPTEQESEQRKAVDLFFDCNAGVELTDSEDDNETKEAMLVGAARANQHHSTDAEMGKKLIQQINQSSEAFVQMMRLAEAATSIAAKSSVPSKDATSSGENGKPSSSSAPEDIDRLLVAGEKIPNRGGRSLTTGFGRQDFVAVAPTKPTVASDAPKDIEITLKLGPDNDSKGRPPETYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WAV6</accession>
    <name>A0A084WAV6_ANOSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">coq3</name>
        <name evidence="6" type="ORF">ZHAS_00015559</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="ATLV01022269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525331">
        <property type="protein sequence ID" value="KFB47350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WAV6"/>
    <dbReference type="STRING" id="74873.A0A084WAV6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015559-RA">
        <property type="protein sequence ID" value="ASIC015559-PA"/>
        <property type="gene ID" value="ASIC015559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015559"/>
    <dbReference type="VEuPathDB" id="VectorBase:ASIS017220"/>
    <dbReference type="OMA" id="KGYRHVG"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    </dbReference>
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        <location>
            <position position="57"/>
        </location>
        <ligand>
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        <location>
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            <dbReference type="EnsemblMetazoa" id="ASIC015559-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="270" mass="30921" checksum="955DC2505A010045" modified="2014-10-29" version="1">MVVKCFQKLSIAFLSVMEGISMRSTAEEQIRTFDQQSAHWWEPNGPMVLLHRLNKLRVPLVVEGLIKVGKLDRKQRYTTDALKGLSILDVGCGGGIYSEALAKLQATVVGIDPAQHLIEVAKAHAEKQSDIRDHCQYRAESMEQHWESAVGKYDVVVLSETLEHVRDKSTLLKQVAAVLKPGGSVFISTWNRTTFAWLMAIVLLENITKRLPRGSHDYDQFIEPEETQGILEGYNCRTIECRPFYLKFWEDEWVWVPFRKFTYALHAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WB58</accession>
    <name>A0A084WB58_ANOSI</name>
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            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
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                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="22"/>
            <end position="55"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB47452.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
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                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KFB47574.1"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="73" mass="7905" checksum="AB0D937952CD3946" modified="2014-10-29" version="1">MSPVRRESRARRICPASQPPGRSQCSRFMGHRFYGIASPSHGVAPVGRVFVPPRLLGPTPTVGTESVLRVHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBK0</accession>
    <name>A0A084WBK0_ANOSI</name>
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        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ZHAS_00015563</name>
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    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
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            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KFB47594.1"/>
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        <property type="gene ID" value="ASIC015563"/>
    </dbReference>
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    <dbReference type="OMA" id="KMWTTAV"/>
    <dbReference type="OrthoDB" id="7871925at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015563-PA"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="85" mass="8808" checksum="34DCD62B352A0F3C" modified="2014-10-29" version="1">MDGGVSSSRFTKMWTTAVLNAITSRATSASKNLSVRYSSIPSNDGAASSASASNLSKIMGGSGIILPLDVEETVTCFCSMSRLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WBV9</accession>
    <name>A0A084WBV9_ANOSI</name>
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        <submittedName>
            <fullName evidence="2 3">DNA uptake protein and related DNA-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ZHAS_00015752</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Anopheles sinensis</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
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            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KFB47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WBV9"/>
    <dbReference type="EnsemblMetazoa" id="ASIC015752-RA">
        <property type="protein sequence ID" value="ASIC015752-PA"/>
        <property type="gene ID" value="ASIC015752"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC015752"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KFB47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC015752-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="96" mass="10506" checksum="5DBA386B0C5FD140" modified="2014-10-29" version="1">MPGLWPKTGAFGGQRTGRHARRVGGTETTSRLISHEKSGETHTDTNAGGGYTRRTEIGLPKINSNRRHSHSLAENPYGRAENDTIISLFPSNRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WDP6</accession>
    <name>A0A084WDP6_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016324</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525339">
        <property type="protein sequence ID" value="KFB48340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WDP6"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016324-RA">
        <property type="protein sequence ID" value="ASIC016324-PA"/>
        <property type="gene ID" value="ASIC016324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016324"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016324-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="61" mass="7318" checksum="445BBECF808ACE0F" modified="2014-10-29" version="1">MQPFWPRLNVVFREMYQKCLMDSMPCKKSSPGWFFFNIPIMEDFVLELSFIRNMSSLQGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEW4</accession>
    <name>A0A084WEW4_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AGAP005368-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ZHAS_00016764</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ATLV01023259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ATLV01023260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KE525341">
        <property type="protein sequence ID" value="KFB48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A084WEW4"/>
    <dbReference type="STRING" id="74873.A0A084WEW4"/>
    <dbReference type="EnsemblMetazoa" id="ASIC016764-RA">
        <property type="protein sequence ID" value="ASIC016764-PA"/>
        <property type="gene ID" value="ASIC016764"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="VectorBase:ASIC016764"/>
    <dbReference type="OMA" id="FTGQDYV"/>
    <dbReference type="OrthoDB" id="10055432at2759"/>
    <dbReference type="Proteomes" id="UP000030765">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153:SF2">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KFB48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="ASIC016764-PA"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030765"/>
        </source>
    </evidence>
    <sequence length="140" mass="15255" checksum="9BD9FA9A8665844A" modified="2014-10-29" version="1">MTNANRTPPLGLSPVVEVLFGRSLDGSQCRDTPSRLCKTRYNTTAPMYGVSLTSGQPVTIVQKFPDLLQQVVFEVCESSECDVVRGECTQTYVPYLFLVIPLGPVTLTGQDYVLVESGCVCKPKYATDKPRETGGGNFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A084WEY8</accession>
    <name>A0A084WEY8_ANOSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AGAP005353-PA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ZHAS_00016792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Anopheles sinensis</name>
        <name type="common">Mosquito</name>
        <dbReference type="NCBI Taxonomy" id="74873"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Diptera</taxon>
            <taxon>Nematocera</taxon>
            <taxon>Culicoidea</taxon>
            <taxon>Culicidae</taxon>
            <taxon>Anophelinae</taxon>
            <taxon>Anopheles</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="42" last="42">
            <title>Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.</title>
            <authorList>
                <person name="Zhou D."/>
                <person name="Zhang D."/>
                <person name="Ding G."/>
                <person name="Shi L."/>
                <person name="Hou Q."/>
                <person name="Ye Y."/>
                <person name="Xu Y."/>
                <person name="Zhou H."/>
                <person name="Xiong C."/>
                <person name="Li S."/>
                <person name="Yu J."/>
                <person name="Hong S."/>
                <person name="Yu X."/>
                <person name="Zou P."/>
                <person name="Chen C."/>
                <person name="Chang X."/>
                <person name="Wang W."/>
                <person name="Lv Y."/>
                <person name="Sun Y."/>
                <person name="Ma L."/>
                <person name="Shen B."/>
                <person name="Zhu C."/>
            </authorList>
            <dbReference type="PubMed" id="24438588"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-42"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment
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